Amino acid dipepetide frequency for Stakelama pacifica

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	18.042AlaAla: 18.042 ± 0.182	0.983AlaCys: 0.983 ± 0.028	7.744AlaAsp: 7.744 ± 0.09	7.733AlaGlu: 7.733 ± 0.103	4.196AlaPhe: 4.196 ± 0.062	10.995AlaGly: 10.995 ± 0.104	2.392AlaHis: 2.392 ± 0.044	7.022AlaIle: 7.022 ± 0.082	4.316AlaLys: 4.316 ± 0.068	13.777AlaLeu: 13.777 ± 0.134	4.141AlaMet: 4.141 ± 0.07	3.117AlaAsn: 3.117 ± 0.056	6.212AlaPro: 6.212 ± 0.112	4.421AlaGln: 4.421 ± 0.077	9.735AlaArg: 9.735 ± 0.12	6.446AlaSer: 6.446 ± 0.089	6.18AlaThr: 6.18 ± 0.083	8.305AlaVal: 8.305 ± 0.099	1.502AlaTrp: 1.502 ± 0.035	2.449AlaTyr: 2.449 ± 0.047	0.0AlaXaa: 0.0 ± 0.0
Cys	0.971CysAla: 0.971 ± 0.03	0.096CysCys: 0.096 ± 0.011	0.515CysAsp: 0.515 ± 0.023	0.425CysGlu: 0.425 ± 0.019	0.29CysPhe: 0.29 ± 0.016	0.777CysGly: 0.777 ± 0.028	0.2CysHis: 0.2 ± 0.016	0.357CysIle: 0.357 ± 0.018	0.151CysLys: 0.151 ± 0.013	0.643CysLeu: 0.643 ± 0.024	0.134CysMet: 0.134 ± 0.011	0.195CysAsn: 0.195 ± 0.013	0.408CysPro: 0.408 ± 0.021	0.19CysGln: 0.19 ± 0.012	0.555CysArg: 0.555 ± 0.022	0.426CysSer: 0.426 ± 0.02	0.371CysThr: 0.371 ± 0.019	0.534CysVal: 0.534 ± 0.022	0.132CysTrp: 0.132 ± 0.011	0.184CysTyr: 0.184 ± 0.014	0.0CysXaa: 0.0 ± 0.0
Asp	8.094AspAla: 8.094 ± 0.098	0.469AspCys: 0.469 ± 0.02	3.561AspAsp: 3.561 ± 0.068	3.51AspGlu: 3.51 ± 0.068	2.22AspPhe: 2.22 ± 0.041	5.57AspGly: 5.57 ± 0.101	1.511AspHis: 1.511 ± 0.036	3.125AspIle: 3.125 ± 0.051	1.803AspLys: 1.803 ± 0.038	5.778AspLeu: 5.778 ± 0.066	1.598AspMet: 1.598 ± 0.037	1.432AspAsn: 1.432 ± 0.04	3.881AspPro: 3.881 ± 0.067	2.01AspGln: 2.01 ± 0.046	5.224AspArg: 5.224 ± 0.071	2.996AspSer: 2.996 ± 0.056	3.052AspThr: 3.052 ± 0.053	3.979AspVal: 3.979 ± 0.069	1.172AspTrp: 1.172 ± 0.031	1.664AspTyr: 1.664 ± 0.041	0.0AspXaa: 0.0 ± 0.0
Glu	8.057GluAla: 8.057 ± 0.107	0.325GluCys: 0.325 ± 0.017	2.906GluAsp: 2.906 ± 0.056	3.011GluGlu: 3.011 ± 0.071	1.543GluPhe: 1.543 ± 0.039	4.519GluGly: 4.519 ± 0.068	1.166GluHis: 1.166 ± 0.032	2.981GluIle: 2.981 ± 0.057	2.139GluLys: 2.139 ± 0.054	4.904GluLeu: 4.904 ± 0.079	1.424GluMet: 1.424 ± 0.035	1.441GluAsn: 1.441 ± 0.036	2.629GluPro: 2.629 ± 0.042	2.164GluGln: 2.164 ± 0.047	5.439GluArg: 5.439 ± 0.086	2.59GluSer: 2.59 ± 0.053	3.313GluThr: 3.313 ± 0.052	3.54GluVal: 3.54 ± 0.061	0.809GluTrp: 0.809 ± 0.026	1.079GluTyr: 1.079 ± 0.034	0.0GluXaa: 0.0 ± 0.0
Phe	4.852PheAla: 4.852 ± 0.071	0.275PheCys: 0.275 ± 0.015	2.765PheAsp: 2.765 ± 0.057	2.014PheGlu: 2.014 ± 0.045	1.279PhePhe: 1.279 ± 0.041	3.503PheGly: 3.503 ± 0.055	0.737PheHis: 0.737 ± 0.023	1.39PheIle: 1.39 ± 0.036	0.743PheLys: 0.743 ± 0.025	3.111PheLeu: 3.111 ± 0.055	0.702PheMet: 0.702 ± 0.024	1.002PheAsn: 1.002 ± 0.032	1.466PhePro: 1.466 ± 0.036	0.876PheGln: 0.876 ± 0.026	2.306PheArg: 2.306 ± 0.042	2.059PheSer: 2.059 ± 0.043	2.034PheThr: 2.034 ± 0.044	2.564PheVal: 2.564 ± 0.041	0.541PheTrp: 0.541 ± 0.02	0.935PheTyr: 0.935 ± 0.031	0.0PheXaa: 0.0 ± 0.0
Gly	9.653GlyAla: 9.653 ± 0.099	0.822GlyCys: 0.822 ± 0.03	5.332GlyAsp: 5.332 ± 0.075	5.32GlyGlu: 5.32 ± 0.077	3.548GlyPhe: 3.548 ± 0.061	7.845GlyGly: 7.845 ± 0.121	1.803GlyHis: 1.803 ± 0.038	4.52GlyIle: 4.52 ± 0.064	3.354GlyLys: 3.354 ± 0.06	8.046GlyLeu: 8.046 ± 0.098	2.511GlyMet: 2.511 ± 0.051	2.361GlyAsn: 2.361 ± 0.064	3.553GlyPro: 3.553 ± 0.051	2.829GlyGln: 2.829 ± 0.054	6.264GlyArg: 6.264 ± 0.08	5.032GlySer: 5.032 ± 0.091	4.842GlyThr: 4.842 ± 0.11	6.038GlyVal: 6.038 ± 0.074	1.623GlyTrp: 1.623 ± 0.036	2.402GlyTyr: 2.402 ± 0.051	0.0GlyXaa: 0.0 ± 0.0
His	2.405HisAla: 2.405 ± 0.041	0.22HisCys: 0.22 ± 0.015	1.318HisAsp: 1.318 ± 0.037	1.008HisGlu: 1.008 ± 0.03	0.878HisPhe: 0.878 ± 0.024	2.028HisGly: 2.028 ± 0.053	0.607HisHis: 0.607 ± 0.024	1.022HisIle: 1.022 ± 0.03	0.461HisLys: 0.461 ± 0.02	1.845HisLeu: 1.845 ± 0.041	0.487HisMet: 0.487 ± 0.022	0.426HisAsn: 0.426 ± 0.017	1.294HisPro: 1.294 ± 0.034	0.597HisGln: 0.597 ± 0.022	1.623HisArg: 1.623 ± 0.037	1.018HisSer: 1.018 ± 0.031	0.69HisThr: 0.69 ± 0.023	1.462HisVal: 1.462 ± 0.035	0.378HisTrp: 0.378 ± 0.019	0.546HisTyr: 0.546 ± 0.023	0.0HisXaa: 0.0 ± 0.0
Ile	8.211IleAla: 8.211 ± 0.093	0.44IleCys: 0.44 ± 0.02	4.133IleAsp: 4.133 ± 0.059	3.701IleGlu: 3.701 ± 0.06	1.577IlePhe: 1.577 ± 0.041	5.395IleGly: 5.395 ± 0.085	0.875IleHis: 0.875 ± 0.026	2.069IleIle: 2.069 ± 0.044	1.085IleLys: 1.085 ± 0.032	4.105IleLeu: 4.105 ± 0.069	0.864IleMet: 0.864 ± 0.03	1.259IleAsn: 1.259 ± 0.036	2.22IlePro: 2.22 ± 0.042	1.085IleGln: 1.085 ± 0.033	3.467IleArg: 3.467 ± 0.052	2.694IleSer: 2.694 ± 0.053	2.599IleThr: 2.599 ± 0.041	4.074IleVal: 4.074 ± 0.057	0.661IleTrp: 0.661 ± 0.027	0.995IleTyr: 0.995 ± 0.032	0.0IleXaa: 0.0 ± 0.0
Lys	4.045LysAla: 4.045 ± 0.075	0.149LysCys: 0.149 ± 0.012	1.558LysAsp: 1.558 ± 0.044	1.332LysGlu: 1.332 ± 0.042	0.835LysPhe: 0.835 ± 0.033	2.67LysGly: 2.67 ± 0.05	0.546LysHis: 0.546 ± 0.024	1.459LysIle: 1.459 ± 0.036	1.168LysLys: 1.168 ± 0.049	3.143LysLeu: 3.143 ± 0.054	0.775LysMet: 0.775 ± 0.028	0.777LysAsn: 0.777 ± 0.025	2.014LysPro: 2.014 ± 0.048	1.015LysGln: 1.015 ± 0.033	2.507LysArg: 2.507 ± 0.05	1.654LysSer: 1.654 ± 0.039	1.711LysThr: 1.711 ± 0.041	2.165LysVal: 2.165 ± 0.048	0.396LysTrp: 0.396 ± 0.019	0.615LysTyr: 0.615 ± 0.026	0.0LysXaa: 0.0 ± 0.0
Leu	12.995LeuAla: 12.995 ± 0.123	0.764LeuCys: 0.764 ± 0.029	6.152LeuAsp: 6.152 ± 0.079	4.484LeuGlu: 4.484 ± 0.073	3.602LeuPhe: 3.602 ± 0.06	7.988LeuGly: 7.988 ± 0.08	1.852LeuHis: 1.852 ± 0.036	5.25LeuIle: 5.25 ± 0.075	3.013LeuLys: 3.013 ± 0.05	8.898LeuLeu: 8.898 ± 0.113	2.071LeuMet: 2.071 ± 0.045	2.555LeuAsn: 2.555 ± 0.05	5.439LeuPro: 5.439 ± 0.064	2.392LeuGln: 2.392 ± 0.047	6.813LeuArg: 6.813 ± 0.091	6.226LeuSer: 6.226 ± 0.089	5.595LeuThr: 5.595 ± 0.079	6.701LeuVal: 6.701 ± 0.091	1.232LeuTrp: 1.232 ± 0.033	1.993LeuTyr: 1.993 ± 0.039	0.0LeuXaa: 0.0 ± 0.0
Met	3.305MetAla: 3.305 ± 0.062	0.14MetCys: 0.14 ± 0.011	1.147MetAsp: 1.147 ± 0.034	1.071MetGlu: 1.071 ± 0.03	0.736MetPhe: 0.736 ± 0.025	1.912MetGly: 1.912 ± 0.042	0.455MetHis: 0.455 ± 0.017	1.439MetIle: 1.439 ± 0.034	0.985MetLys: 0.985 ± 0.029	2.721MetLeu: 2.721 ± 0.053	0.692MetMet: 0.692 ± 0.029	0.75MetAsn: 0.75 ± 0.028	1.491MetPro: 1.491 ± 0.039	0.774MetGln: 0.774 ± 0.025	1.977MetArg: 1.977 ± 0.039	1.454MetSer: 1.454 ± 0.034	1.831MetThr: 1.831 ± 0.036	1.76MetVal: 1.76 ± 0.038	0.207MetTrp: 0.207 ± 0.014	0.297MetTyr: 0.297 ± 0.018	0.0MetXaa: 0.0 ± 0.0
Asn	3.357AsnAla: 3.357 ± 0.056	0.214AsnCys: 0.214 ± 0.015	1.525AsnAsp: 1.525 ± 0.041	1.243AsnGlu: 1.243 ± 0.037	0.905AsnPhe: 0.905 ± 0.031	2.475AsnGly: 2.475 ± 0.059	0.508AsnHis: 0.508 ± 0.023	1.334AsnIle: 1.334 ± 0.031	0.67AsnLys: 0.67 ± 0.026	2.419AsnLeu: 2.419 ± 0.049	0.594AsnMet: 0.594 ± 0.023	0.671AsnAsn: 0.671 ± 0.025	1.737AsnPro: 1.737 ± 0.039	0.802AsnGln: 0.802 ± 0.029	2.019AsnArg: 2.019 ± 0.04	1.31AsnSer: 1.31 ± 0.034	1.083AsnThr: 1.083 ± 0.032	1.865AsnVal: 1.865 ± 0.046	0.435AsnTrp: 0.435 ± 0.023	0.746AsnTyr: 0.746 ± 0.029	0.0AsnXaa: 0.0 ± 0.0
Pro	6.442ProAla: 6.442 ± 0.088	0.35ProCys: 0.35 ± 0.019	4.403ProAsp: 4.403 ± 0.077	3.701ProGlu: 3.701 ± 0.065	1.852ProPhe: 1.852 ± 0.044	4.871ProGly: 4.871 ± 0.066	1.065ProHis: 1.065 ± 0.03	2.432ProIle: 2.432 ± 0.044	1.54ProLys: 1.54 ± 0.033	4.731ProLeu: 4.731 ± 0.064	1.252ProMet: 1.252 ± 0.032	1.312ProAsn: 1.312 ± 0.034	2.703ProPro: 2.703 ± 0.066	1.684ProGln: 1.684 ± 0.042	3.087ProArg: 3.087 ± 0.059	2.533ProSer: 2.533 ± 0.052	2.401ProThr: 2.401 ± 0.047	4.265ProVal: 4.265 ± 0.07	0.695ProTrp: 0.695 ± 0.029	1.182ProTyr: 1.182 ± 0.033	0.0ProXaa: 0.0 ± 0.0
Gln	4.11GlnAla: 4.11 ± 0.069	0.23GlnCys: 0.23 ± 0.016	1.45GlnAsp: 1.45 ± 0.035	1.37GlnGlu: 1.37 ± 0.037	1.051GlnPhe: 1.051 ± 0.032	2.48GlnGly: 2.48 ± 0.051	0.623GlnHis: 0.623 ± 0.023	1.717GlnIle: 1.717 ± 0.041	0.97GlnLys: 0.97 ± 0.029	2.931GlnLeu: 2.931 ± 0.048	0.836GlnMet: 0.836 ± 0.025	0.824GlnAsn: 0.824 ± 0.028	1.777GlnPro: 1.777 ± 0.042	1.297GlnGln: 1.297 ± 0.041	2.634GlnArg: 2.634 ± 0.053	1.897GlnSer: 1.897 ± 0.043	1.6GlnThr: 1.6 ± 0.036	2.21GlnVal: 2.21 ± 0.043	0.522GlnTrp: 0.522 ± 0.021	0.639GlnTyr: 0.639 ± 0.026	0.0GlnXaa: 0.0 ± 0.0
Arg	8.954ArgAla: 8.954 ± 0.098	0.512ArgCys: 0.512 ± 0.024	4.75ArgAsp: 4.75 ± 0.075	4.504ArgGlu: 4.504 ± 0.067	3.234ArgPhe: 3.234 ± 0.057	5.167ArgGly: 5.167 ± 0.073	1.741ArgHis: 1.741 ± 0.045	4.407ArgIle: 4.407 ± 0.064	2.193ArgLys: 2.193 ± 0.048	8.013ArgLeu: 8.013 ± 0.106	2.11ArgMet: 2.11 ± 0.046	1.991ArgAsn: 1.991 ± 0.039	3.669ArgPro: 3.669 ± 0.062	2.528ArgGln: 2.528 ± 0.047	5.985ArgArg: 5.985 ± 0.087	4.032ArgSer: 4.032 ± 0.067	3.626ArgThr: 3.626 ± 0.055	4.847ArgVal: 4.847 ± 0.072	1.26ArgTrp: 1.26 ± 0.036	1.978ArgTyr: 1.978 ± 0.047	0.0ArgXaa: 0.0 ± 0.0
Ser	6.797SerAla: 6.797 ± 0.087	0.381SerCys: 0.381 ± 0.018	3.647SerAsp: 3.647 ± 0.052	2.912SerGlu: 2.912 ± 0.05	2.088SerPhe: 2.088 ± 0.04	5.97SerGly: 5.97 ± 0.094	1.032SerHis: 1.032 ± 0.028	2.669SerIle: 2.669 ± 0.043	1.471SerLys: 1.471 ± 0.036	5.029SerLeu: 5.029 ± 0.063	1.226SerMet: 1.226 ± 0.033	1.447SerAsn: 1.447 ± 0.037	2.961SerPro: 2.961 ± 0.057	1.524SerGln: 1.524 ± 0.03	3.607SerArg: 3.607 ± 0.051	2.684SerSer: 2.684 ± 0.057	2.521SerThr: 2.521 ± 0.055	3.886SerVal: 3.886 ± 0.059	0.768SerTrp: 0.768 ± 0.026	1.377SerTyr: 1.377 ± 0.044	0.0SerXaa: 0.0 ± 0.0
Thr	6.122ThrAla: 6.122 ± 0.108	0.341ThrCys: 0.341 ± 0.018	3.136ThrAsp: 3.136 ± 0.058	2.404ThrGlu: 2.404 ± 0.048	1.741ThrPhe: 1.741 ± 0.037	5.346ThrGly: 5.346 ± 0.088	0.961ThrHis: 0.961 ± 0.031	3.068ThrIle: 3.068 ± 0.049	1.348ThrLys: 1.348 ± 0.035	5.807ThrLeu: 5.807 ± 0.075	1.264ThrMet: 1.264 ± 0.033	1.349ThrAsn: 1.349 ± 0.035	3.352ThrPro: 3.352 ± 0.069	1.485ThrGln: 1.485 ± 0.034	3.516ThrArg: 3.516 ± 0.048	2.677ThrSer: 2.677 ± 0.046	2.479ThrThr: 2.479 ± 0.046	4.109ThrVal: 4.109 ± 0.084	0.539ThrTrp: 0.539 ± 0.025	1.203ThrTyr: 1.203 ± 0.033	0.0ThrXaa: 0.0 ± 0.0
Val	9.199ValAla: 9.199 ± 0.108	0.466ValCys: 0.466 ± 0.019	4.287ValAsp: 4.287 ± 0.063	4.52ValGlu: 4.52 ± 0.071	2.142ValPhe: 2.142 ± 0.041	5.13ValGly: 5.13 ± 0.067	1.343ValHis: 1.343 ± 0.033	3.582ValIle: 3.582 ± 0.063	2.04ValLys: 2.04 ± 0.045	6.333ValLeu: 6.333 ± 0.079	1.665ValMet: 1.665 ± 0.043	1.899ValAsn: 1.899 ± 0.047	3.878ValPro: 3.878 ± 0.058	2.074ValGln: 2.074 ± 0.042	5.342ValArg: 5.342 ± 0.071	4.088ValSer: 4.088 ± 0.065	4.467ValThr: 4.467 ± 0.081	4.879ValVal: 4.879 ± 0.082	0.793ValTrp: 0.793 ± 0.025	1.378ValTyr: 1.378 ± 0.037	0.0ValXaa: 0.0 ± 0.0
Trp	1.398TrpAla: 1.398 ± 0.036	0.128TrpCys: 0.128 ± 0.011	0.728TrpAsp: 0.728 ± 0.024	0.621TrpGlu: 0.621 ± 0.025	0.596TrpPhe: 0.596 ± 0.026	0.931TrpGly: 0.931 ± 0.035	0.36TrpHis: 0.36 ± 0.017	0.725TrpIle: 0.725 ± 0.025	0.501TrpLys: 0.501 ± 0.02	1.642TrpLeu: 1.642 ± 0.04	0.397TrpMet: 0.397 ± 0.018	0.482TrpAsn: 0.482 ± 0.023	0.7TrpPro: 0.7 ± 0.022	0.644TrpGln: 0.644 ± 0.026	1.343TrpArg: 1.343 ± 0.038	0.871TrpSer: 0.871 ± 0.03	0.793TrpThr: 0.793 ± 0.027	0.831TrpVal: 0.831 ± 0.027	0.274TrpTrp: 0.274 ± 0.016	0.325TrpTyr: 0.325 ± 0.016	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.699TyrAla: 2.699 ± 0.05	0.246TyrCys: 0.246 ± 0.014	1.594TyrAsp: 1.594 ± 0.045	1.094TyrGlu: 1.094 ± 0.033	0.841TyrPhe: 0.841 ± 0.03	2.124TyrGly: 2.124 ± 0.053	0.536TyrHis: 0.536 ± 0.025	0.939TyrIle: 0.939 ± 0.027	0.581TyrLys: 0.581 ± 0.024	2.142TyrLeu: 2.142 ± 0.047	0.399TyrMet: 0.399 ± 0.02	0.622TyrAsn: 0.622 ± 0.024	1.116TyrPro: 1.116 ± 0.035	0.779TyrGln: 0.779 ± 0.029	2.058TyrArg: 2.058 ± 0.043	1.31TyrSer: 1.31 ± 0.046	1.063TyrThr: 1.063 ± 0.038	1.49TyrVal: 1.49 ± 0.037	0.353TyrTrp: 0.353 ± 0.017	0.639TyrTyr: 0.639 ± 0.029	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3799 proteins (1198406 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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