Amino acid dipepetide frequency for Venturia nashicola

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	8.497AlaAla: 8.497 ± 0.065	1.022AlaCys: 1.022 ± 0.013	3.994AlaAsp: 3.994 ± 0.03	5.056AlaGlu: 5.056 ± 0.04	3.089AlaPhe: 3.089 ± 0.029	5.719AlaGly: 5.719 ± 0.038	1.734AlaHis: 1.734 ± 0.017	4.341AlaIle: 4.341 ± 0.035	4.565AlaLys: 4.565 ± 0.04	7.364AlaLeu: 7.364 ± 0.038	2.012AlaMet: 2.012 ± 0.022	3.008AlaAsn: 3.008 ± 0.026	5.05AlaPro: 5.05 ± 0.047	3.369AlaGln: 3.369 ± 0.029	4.678AlaArg: 4.678 ± 0.032	7.258AlaSer: 7.258 ± 0.046	5.315AlaThr: 5.315 ± 0.03	5.182AlaVal: 5.182 ± 0.036	1.13AlaTrp: 1.13 ± 0.015	2.098AlaTyr: 2.098 ± 0.022	0.001AlaXaa: 0.001 ± 0.0
Cys	0.906CysAla: 0.906 ± 0.013	0.25CysCys: 0.25 ± 0.008	0.612CysAsp: 0.612 ± 0.011	0.591CysGlu: 0.591 ± 0.012	0.535CysPhe: 0.535 ± 0.011	0.924CysGly: 0.924 ± 0.015	0.323CysHis: 0.323 ± 0.009	0.661CysIle: 0.661 ± 0.012	0.577CysLys: 0.577 ± 0.012	1.178CysLeu: 1.178 ± 0.016	0.27CysMet: 0.27 ± 0.007	0.432CysAsn: 0.432 ± 0.011	0.654CysPro: 0.654 ± 0.013	0.44CysGln: 0.44 ± 0.01	0.701CysArg: 0.701 ± 0.012	0.888CysSer: 0.888 ± 0.015	0.7CysThr: 0.7 ± 0.012	0.744CysVal: 0.744 ± 0.014	0.196CysTrp: 0.196 ± 0.006	0.361CysTyr: 0.361 ± 0.008	0.0CysXaa: 0.0 ± 0.0
Asp	4.469AspAla: 4.469 ± 0.032	0.636AspCys: 0.636 ± 0.013	4.071AspAsp: 4.071 ± 0.041	4.515AspGlu: 4.515 ± 0.044	2.236AspPhe: 2.236 ± 0.023	4.073AspGly: 4.073 ± 0.034	1.237AspHis: 1.237 ± 0.017	2.97AspIle: 2.97 ± 0.024	2.52AspLys: 2.52 ± 0.026	4.837AspLeu: 4.837 ± 0.035	1.334AspMet: 1.334 ± 0.013	1.821AspAsn: 1.821 ± 0.022	3.149AspPro: 3.149 ± 0.027	1.832AspGln: 1.832 ± 0.021	2.869AspArg: 2.869 ± 0.027	4.083AspSer: 4.083 ± 0.032	2.917AspThr: 2.917 ± 0.025	3.504AspVal: 3.504 ± 0.031	0.879AspTrp: 0.879 ± 0.013	1.512AspTyr: 1.512 ± 0.018	0.001AspXaa: 0.001 ± 0.0
Glu	5.332GluAla: 5.332 ± 0.043	0.612GluCys: 0.612 ± 0.013	4.35GluAsp: 4.35 ± 0.042	5.965GluGlu: 5.965 ± 0.065	1.9GluPhe: 1.9 ± 0.019	3.875GluGly: 3.875 ± 0.037	1.385GluHis: 1.385 ± 0.019	3.071GluIle: 3.071 ± 0.026	4.147GluLys: 4.147 ± 0.038	5.037GluLeu: 5.037 ± 0.037	1.603GluMet: 1.603 ± 0.02	2.304GluAsn: 2.304 ± 0.021	2.767GluPro: 2.767 ± 0.035	2.512GluGln: 2.512 ± 0.026	3.978GluArg: 3.978 ± 0.037	4.221GluSer: 4.221 ± 0.036	3.428GluThr: 3.428 ± 0.028	3.604GluVal: 3.604 ± 0.032	0.884GluTrp: 0.884 ± 0.015	1.597GluTyr: 1.597 ± 0.017	0.001GluXaa: 0.001 ± 0.0
Phe	3.094PheAla: 3.094 ± 0.028	0.542PheCys: 0.542 ± 0.011	2.246PheAsp: 2.246 ± 0.021	2.188PheGlu: 2.188 ± 0.02	1.604PhePhe: 1.604 ± 0.021	2.962PheGly: 2.962 ± 0.031	0.893PheHis: 0.893 ± 0.014	1.778PheIle: 1.778 ± 0.021	1.692PheLys: 1.692 ± 0.019	3.382PheLeu: 3.382 ± 0.028	0.823PheMet: 0.823 ± 0.011	1.44PheAsn: 1.44 ± 0.02	1.922PhePro: 1.922 ± 0.018	1.388PheGln: 1.388 ± 0.017	1.847PheArg: 1.847 ± 0.018	3.023PheSer: 3.023 ± 0.025	2.213PheThr: 2.213 ± 0.022	2.324PheVal: 2.324 ± 0.023	0.634PheTrp: 0.634 ± 0.01	1.036PheTyr: 1.036 ± 0.016	0.0PheXaa: 0.0 ± 0.0
Gly	5.205GlyAla: 5.205 ± 0.04	0.852GlyCys: 0.852 ± 0.015	3.522GlyAsp: 3.522 ± 0.033	3.849GlyGlu: 3.849 ± 0.033	2.814GlyPhe: 2.814 ± 0.028	6.119GlyGly: 6.119 ± 0.064	1.687GlyHis: 1.687 ± 0.02	3.555GlyIle: 3.555 ± 0.031	3.888GlyLys: 3.888 ± 0.036	5.894GlyLeu: 5.894 ± 0.035	1.776GlyMet: 1.776 ± 0.021	2.653GlyAsn: 2.653 ± 0.025	3.314GlyPro: 3.314 ± 0.032	2.589GlyGln: 2.589 ± 0.025	4.08GlyArg: 4.08 ± 0.034	5.617GlySer: 5.617 ± 0.047	4.073GlyThr: 4.073 ± 0.038	4.243GlyVal: 4.243 ± 0.035	1.16GlyTrp: 1.16 ± 0.015	2.053GlyTyr: 2.053 ± 0.023	0.001GlyXaa: 0.001 ± 0.001
His	1.814HisAla: 1.814 ± 0.019	0.328HisCys: 0.328 ± 0.007	1.316HisAsp: 1.316 ± 0.017	1.322HisGlu: 1.322 ± 0.017	0.961HisPhe: 0.961 ± 0.014	1.709HisGly: 1.709 ± 0.019	0.878HisHis: 0.878 ± 0.016	1.221HisIle: 1.221 ± 0.016	1.004HisLys: 1.004 ± 0.014	2.192HisLeu: 2.192 ± 0.021	0.467HisMet: 0.467 ± 0.01	0.888HisAsn: 0.888 ± 0.013	1.598HisPro: 1.598 ± 0.02	1.043HisGln: 1.043 ± 0.016	1.453HisArg: 1.453 ± 0.018	1.924HisSer: 1.924 ± 0.023	1.31HisThr: 1.31 ± 0.018	1.429HisVal: 1.429 ± 0.017	0.345HisTrp: 0.345 ± 0.008	0.683HisTyr: 0.683 ± 0.012	0.0HisXaa: 0.0 ± 0.0
Ile	4.311IleAla: 4.311 ± 0.033	0.744IleCys: 0.744 ± 0.015	2.845IleAsp: 2.845 ± 0.021	2.978IleGlu: 2.978 ± 0.03	1.99IlePhe: 1.99 ± 0.024	3.229IleGly: 3.229 ± 0.03	1.248IleHis: 1.248 ± 0.015	2.532IleIle: 2.532 ± 0.028	2.453IleLys: 2.453 ± 0.024	4.541IleLeu: 4.541 ± 0.03	1.047IleMet: 1.047 ± 0.013	1.882IleAsn: 1.882 ± 0.021	3.2IlePro: 3.2 ± 0.029	1.955IleGln: 1.955 ± 0.02	2.715IleArg: 2.715 ± 0.025	3.973IleSer: 3.973 ± 0.032	3.033IleThr: 3.033 ± 0.026	3.159IleVal: 3.159 ± 0.027	0.742IleTrp: 0.742 ± 0.013	1.373IleTyr: 1.373 ± 0.018	0.0IleXaa: 0.0 ± 0.0
Lys	4.776LysAla: 4.776 ± 0.042	0.541LysCys: 0.541 ± 0.011	3.112LysAsp: 3.112 ± 0.033	3.937LysGlu: 3.937 ± 0.042	1.629LysPhe: 1.629 ± 0.02	3.314LysGly: 3.314 ± 0.034	1.205LysHis: 1.205 ± 0.016	2.632LysIle: 2.632 ± 0.023	4.046LysLys: 4.046 ± 0.057	4.253LysLeu: 4.253 ± 0.033	1.201LysMet: 1.201 ± 0.018	1.985LysAsn: 1.985 ± 0.021	2.977LysPro: 2.977 ± 0.033	2.031LysGln: 2.031 ± 0.018	3.694LysArg: 3.694 ± 0.036	3.929LysSer: 3.929 ± 0.035	3.206LysThr: 3.206 ± 0.027	3.045LysVal: 3.045 ± 0.024	0.752LysTrp: 0.752 ± 0.012	1.405LysTyr: 1.405 ± 0.018	0.0LysXaa: 0.0 ± 0.0
Leu	7.483LeuAla: 7.483 ± 0.041	1.118LeuCys: 1.118 ± 0.017	4.943LeuAsp: 4.943 ± 0.033	5.315LeuGlu: 5.315 ± 0.043	3.268LeuPhe: 3.268 ± 0.032	5.697LeuGly: 5.697 ± 0.042	2.18LeuHis: 2.18 ± 0.025	3.906LeuIle: 3.906 ± 0.034	4.473LeuLys: 4.473 ± 0.034	7.89LeuLeu: 7.89 ± 0.053	1.796LeuMet: 1.796 ± 0.018	3.193LeuAsn: 3.193 ± 0.025	5.511LeuPro: 5.511 ± 0.038	3.709LeuGln: 3.709 ± 0.036	5.332LeuArg: 5.332 ± 0.044	7.08LeuSer: 7.08 ± 0.04	4.821LeuThr: 4.821 ± 0.033	5.031LeuVal: 5.031 ± 0.037	1.145LeuTrp: 1.145 ± 0.019	2.174LeuTyr: 2.174 ± 0.024	0.001LeuXaa: 0.001 ± 0.0
Met	2.266MetAla: 2.266 ± 0.022	0.242MetCys: 0.242 ± 0.007	1.375MetAsp: 1.375 ± 0.015	1.422MetGlu: 1.422 ± 0.017	0.77MetPhe: 0.77 ± 0.013	1.572MetGly: 1.572 ± 0.022	0.482MetHis: 0.482 ± 0.012	1.044MetIle: 1.044 ± 0.014	1.2MetLys: 1.2 ± 0.017	1.874MetLeu: 1.874 ± 0.023	0.627MetMet: 0.627 ± 0.013	0.877MetAsn: 0.877 ± 0.014	1.345MetPro: 1.345 ± 0.018	0.877MetGln: 0.877 ± 0.016	1.306MetArg: 1.306 ± 0.016	1.993MetSer: 1.993 ± 0.019	1.314MetThr: 1.314 ± 0.017	1.329MetVal: 1.329 ± 0.017	0.255MetTrp: 0.255 ± 0.007	0.542MetTyr: 0.542 ± 0.011	0.0MetXaa: 0.0 ± 0.0
Asn	3.194AsnAla: 3.194 ± 0.025	0.462AsnCys: 0.462 ± 0.011	1.971AsnAsp: 1.971 ± 0.019	2.092AsnGlu: 2.092 ± 0.018	1.461AsnPhe: 1.461 ± 0.02	3.191AsnGly: 3.191 ± 0.034	0.946AsnHis: 0.946 ± 0.013	2.088AsnIle: 2.088 ± 0.021	1.732AsnLys: 1.732 ± 0.019	3.285AsnLeu: 3.285 ± 0.028	0.852AsnMet: 0.852 ± 0.015	1.607AsnAsn: 1.607 ± 0.027	2.497AsnPro: 2.497 ± 0.026	1.456AsnGln: 1.456 ± 0.017	1.939AsnArg: 1.939 ± 0.019	2.999AsnSer: 2.999 ± 0.027	2.303AsnThr: 2.303 ± 0.024	2.291AsnVal: 2.291 ± 0.021	0.569AsnTrp: 0.569 ± 0.01	1.04AsnTyr: 1.04 ± 0.017	0.0AsnXaa: 0.0 ± 0.0
Pro	5.372ProAla: 5.372 ± 0.053	0.486ProCys: 0.486 ± 0.01	2.975ProAsp: 2.975 ± 0.027	3.585ProGlu: 3.585 ± 0.037	2.069ProPhe: 2.069 ± 0.022	3.835ProGly: 3.835 ± 0.033	1.353ProHis: 1.353 ± 0.02	2.817ProIle: 2.817 ± 0.024	3.137ProLys: 3.137 ± 0.036	4.663ProLeu: 4.663 ± 0.034	1.18ProMet: 1.18 ± 0.017	2.366ProAsn: 2.366 ± 0.022	5.511ProPro: 5.511 ± 0.066	2.574ProGln: 2.574 ± 0.031	3.358ProArg: 3.358 ± 0.028	6.159ProSer: 6.159 ± 0.054	4.27ProThr: 4.27 ± 0.037	3.517ProVal: 3.517 ± 0.032	0.702ProTrp: 0.702 ± 0.013	1.522ProTyr: 1.522 ± 0.019	0.002ProXaa: 0.002 ± 0.001
Gln	3.449GlnAla: 3.449 ± 0.032	0.436GlnCys: 0.436 ± 0.009	2.055GlnAsp: 2.055 ± 0.021	2.446GlnGlu: 2.446 ± 0.027	1.336GlnPhe: 1.336 ± 0.017	2.379GlnGly: 2.379 ± 0.021	1.146GlnHis: 1.146 ± 0.018	1.99GlnIle: 1.99 ± 0.022	2.117GlnLys: 2.117 ± 0.024	3.319GlnLeu: 3.319 ± 0.029	0.929GlnMet: 0.929 ± 0.014	1.67GlnAsn: 1.67 ± 0.018	2.546GlnPro: 2.546 ± 0.032	2.655GlnGln: 2.655 ± 0.057	2.575GlnArg: 2.575 ± 0.026	3.193GlnSer: 3.193 ± 0.027	2.43GlnThr: 2.43 ± 0.027	2.107GlnVal: 2.107 ± 0.021	0.545GlnTrp: 0.545 ± 0.01	1.216GlnTyr: 1.216 ± 0.019	0.001GlnXaa: 0.001 ± 0.0
Arg	4.445ArgAla: 4.445 ± 0.03	0.67ArgCys: 0.67 ± 0.013	3.175ArgAsp: 3.175 ± 0.027	3.794ArgGlu: 3.794 ± 0.031	2.036ArgPhe: 2.036 ± 0.021	3.676ArgGly: 3.676 ± 0.033	1.493ArgHis: 1.493 ± 0.016	2.88ArgIle: 2.88 ± 0.028	3.726ArgLys: 3.726 ± 0.031	5.074ArgLeu: 5.074 ± 0.032	1.366ArgMet: 1.366 ± 0.017	2.322ArgAsn: 2.322 ± 0.023	3.495ArgPro: 3.495 ± 0.031	2.6ArgGln: 2.6 ± 0.027	4.853ArgArg: 4.853 ± 0.041	4.645ArgSer: 4.645 ± 0.038	3.302ArgThr: 3.302 ± 0.025	3.15ArgVal: 3.15 ± 0.024	0.872ArgTrp: 0.872 ± 0.015	1.554ArgTyr: 1.554 ± 0.017	0.001ArgXaa: 0.001 ± 0.0
Ser	6.519SerAla: 6.519 ± 0.042	0.88SerCys: 0.88 ± 0.015	4.069SerAsp: 4.069 ± 0.031	4.143SerGlu: 4.143 ± 0.034	3.038SerPhe: 3.038 ± 0.026	5.562SerGly: 5.562 ± 0.043	1.956SerHis: 1.956 ± 0.021	4.167SerIle: 4.167 ± 0.031	4.218SerLys: 4.218 ± 0.035	7.078SerLeu: 7.078 ± 0.04	1.826SerMet: 1.826 ± 0.018	3.248SerAsn: 3.248 ± 0.029	5.767SerPro: 5.767 ± 0.049	3.293SerGln: 3.293 ± 0.03	4.929SerArg: 4.929 ± 0.034	8.849SerSer: 8.849 ± 0.069	5.951SerThr: 5.951 ± 0.043	4.428SerVal: 4.428 ± 0.031	1.075SerTrp: 1.075 ± 0.015	2.056SerTyr: 2.056 ± 0.022	0.001SerXaa: 0.001 ± 0.0
Thr	5.238ThrAla: 5.238 ± 0.036	0.736ThrCys: 0.736 ± 0.014	2.775ThrAsp: 2.775 ± 0.027	3.084ThrGlu: 3.084 ± 0.027	2.324ThrPhe: 2.324 ± 0.025	4.206ThrGly: 4.206 ± 0.037	1.313ThrHis: 1.313 ± 0.017	3.336ThrIle: 3.336 ± 0.025	3.006ThrLys: 3.006 ± 0.025	5.279ThrLeu: 5.279 ± 0.035	1.297ThrMet: 1.297 ± 0.018	2.337ThrAsn: 2.337 ± 0.024	4.593ThrPro: 4.593 ± 0.04	2.157ThrGln: 2.157 ± 0.022	3.145ThrArg: 3.145 ± 0.024	5.731ThrSer: 5.731 ± 0.045	4.621ThrThr: 4.621 ± 0.037	3.588ThrVal: 3.588 ± 0.031	0.827ThrTrp: 0.827 ± 0.013	1.534ThrTyr: 1.534 ± 0.019	0.001ThrXaa: 0.001 ± 0.0
Val	5.009ValAla: 5.009 ± 0.034	0.782ValCys: 0.782 ± 0.014	3.609ValAsp: 3.609 ± 0.03	3.986ValGlu: 3.986 ± 0.034	2.294ValPhe: 2.294 ± 0.027	4.003ValGly: 4.003 ± 0.037	1.335ValHis: 1.335 ± 0.016	2.803ValIle: 2.803 ± 0.025	3.131ValLys: 3.131 ± 0.029	5.21ValLeu: 5.21 ± 0.041	1.33ValMet: 1.33 ± 0.018	2.157ValAsn: 2.157 ± 0.021	3.495ValPro: 3.495 ± 0.028	2.371ValGln: 2.371 ± 0.024	3.247ValArg: 3.247 ± 0.025	4.411ValSer: 4.411 ± 0.03	3.335ValThr: 3.335 ± 0.03	4.121ValVal: 4.121 ± 0.035	0.851ValTrp: 0.851 ± 0.012	1.606ValTyr: 1.606 ± 0.019	0.001ValXaa: 0.001 ± 0.0
Trp	1.048TrpAla: 1.048 ± 0.017	0.195TrpCys: 0.195 ± 0.006	0.857TrpAsp: 0.857 ± 0.014	0.824TrpGlu: 0.824 ± 0.014	0.531TrpPhe: 0.531 ± 0.011	0.883TrpGly: 0.883 ± 0.015	0.354TrpHis: 0.354 ± 0.008	0.782TrpIle: 0.782 ± 0.012	0.864TrpLys: 0.864 ± 0.014	1.269TrpLeu: 1.269 ± 0.02	0.372TrpMet: 0.372 ± 0.008	0.643TrpAsn: 0.643 ± 0.011	0.608TrpPro: 0.608 ± 0.012	0.583TrpGln: 0.583 ± 0.01	0.959TrpArg: 0.959 ± 0.013	1.048TrpSer: 1.048 ± 0.017	0.952TrpThr: 0.952 ± 0.015	0.804TrpVal: 0.804 ± 0.015	0.279TrpTrp: 0.279 ± 0.008	0.409TrpTyr: 0.409 ± 0.009	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.053TyrAla: 2.053 ± 0.02	0.407TyrCys: 0.407 ± 0.009	1.589TyrAsp: 1.589 ± 0.018	1.482TyrGlu: 1.482 ± 0.015	1.147TyrPhe: 1.147 ± 0.016	2.013TyrGly: 2.013 ± 0.025	0.735TyrHis: 0.735 ± 0.01	1.378TyrIle: 1.378 ± 0.019	1.176TyrLys: 1.176 ± 0.015	2.446TyrLeu: 2.446 ± 0.024	0.603TyrMet: 0.603 ± 0.01	1.141TyrAsn: 1.141 ± 0.015	1.454TyrPro: 1.454 ± 0.02	1.109TyrGln: 1.109 ± 0.016	1.467TyrArg: 1.467 ± 0.017	2.029TyrSer: 2.029 ± 0.021	1.636TyrThr: 1.636 ± 0.019	1.485TyrVal: 1.485 ± 0.021	0.423TyrTrp: 0.423 ± 0.012	0.85TyrTyr: 0.85 ± 0.014	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.002XaaAla: 0.002 ± 0.001	0.0XaaCys: 0.0 ± 0.0	0.001XaaAsp: 0.001 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.001XaaGly: 0.001 ± 0.001	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.001XaaLys: 0.001 ± 0.0	0.001XaaLeu: 0.001 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.001XaaPro: 0.001 ± 0.001	0.001XaaGln: 0.001 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.001XaaSer: 0.001 ± 0.0	0.001XaaThr: 0.001 ± 0.001	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.001XaaTyr: 0.001 ± 0.0	0.016XaaXaa: 0.016 ± 0.009

Statistics based on 11754 proteins (5212399 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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