Amino acid dipepetide frequency for Candidatus Berkiella cookevillensis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	6.05AlaAla: 6.05 ± 0.126	0.94AlaCys: 0.94 ± 0.032	3.534AlaAsp: 3.534 ± 0.081	4.556AlaGlu: 4.556 ± 0.095	3.713AlaPhe: 3.713 ± 0.087	4.278AlaGly: 4.278 ± 0.082	2.009AlaHis: 2.009 ± 0.051	6.175AlaIle: 6.175 ± 0.089	5.524AlaLys: 5.524 ± 0.095	9.808AlaLeu: 9.808 ± 0.128	2.037AlaMet: 2.037 ± 0.05	3.257AlaAsn: 3.257 ± 0.071	2.654AlaPro: 2.654 ± 0.065	4.239AlaGln: 4.239 ± 0.078	3.21AlaArg: 3.21 ± 0.076	4.972AlaSer: 4.972 ± 0.081	4.05AlaThr: 4.05 ± 0.079	4.847AlaVal: 4.847 ± 0.099	0.941AlaTrp: 0.941 ± 0.034	2.557AlaTyr: 2.557 ± 0.056	0.0AlaXaa: 0.0 ± 0.0
Cys	0.883CysAla: 0.883 ± 0.032	0.179CysCys: 0.179 ± 0.015	0.539CysAsp: 0.539 ± 0.023	0.648CysGlu: 0.648 ± 0.028	0.61CysPhe: 0.61 ± 0.025	0.8CysGly: 0.8 ± 0.031	0.319CysHis: 0.319 ± 0.021	0.753CysIle: 0.753 ± 0.036	0.566CysLys: 0.566 ± 0.022	1.281CysLeu: 1.281 ± 0.041	0.261CysMet: 0.261 ± 0.019	0.421CysAsn: 0.421 ± 0.023	0.439CysPro: 0.439 ± 0.027	0.503CysGln: 0.503 ± 0.023	0.392CysArg: 0.392 ± 0.022	0.663CysSer: 0.663 ± 0.027	0.517CysThr: 0.517 ± 0.024	0.706CysVal: 0.706 ± 0.029	0.117CysTrp: 0.117 ± 0.012	0.428CysTyr: 0.428 ± 0.024	0.0CysXaa: 0.0 ± 0.0
Asp	4.035AspAla: 4.035 ± 0.091	0.541AspCys: 0.541 ± 0.024	2.319AspAsp: 2.319 ± 0.076	3.371AspGlu: 3.371 ± 0.079	2.604AspPhe: 2.604 ± 0.076	2.674AspGly: 2.674 ± 0.091	0.984AspHis: 0.984 ± 0.037	4.125AspIle: 4.125 ± 0.075	3.762AspLys: 3.762 ± 0.079	5.375AspLeu: 5.375 ± 0.073	1.134AspMet: 1.134 ± 0.036	2.398AspAsn: 2.398 ± 0.052	2.068AspPro: 2.068 ± 0.064	1.641AspGln: 1.641 ± 0.051	1.922AspArg: 1.922 ± 0.054	2.983AspSer: 2.983 ± 0.067	2.501AspThr: 2.501 ± 0.061	3.215AspVal: 3.215 ± 0.063	0.597AspTrp: 0.597 ± 0.026	1.961AspTyr: 1.961 ± 0.045	0.0AspXaa: 0.0 ± 0.0
Glu	5.157GluAla: 5.157 ± 0.105	0.566GluCys: 0.566 ± 0.027	2.965GluAsp: 2.965 ± 0.066	4.103GluGlu: 4.103 ± 0.106	2.185GluPhe: 2.185 ± 0.051	3.148GluGly: 3.148 ± 0.075	1.639GluHis: 1.639 ± 0.041	5.055GluIle: 5.055 ± 0.084	5.825GluLys: 5.825 ± 0.119	5.956GluLeu: 5.956 ± 0.09	1.599GluMet: 1.599 ± 0.036	3.618GluAsn: 3.618 ± 0.068	1.821GluPro: 1.821 ± 0.056	3.282GluGln: 3.282 ± 0.066	2.949GluArg: 2.949 ± 0.071	3.832GluSer: 3.832 ± 0.074	3.027GluThr: 3.027 ± 0.064	3.584GluVal: 3.584 ± 0.07	0.633GluTrp: 0.633 ± 0.028	1.917GluTyr: 1.917 ± 0.049	0.0GluXaa: 0.0 ± 0.0
Phe	3.315PheAla: 3.315 ± 0.076	0.624PheCys: 0.624 ± 0.028	2.623PheAsp: 2.623 ± 0.06	2.735PheGlu: 2.735 ± 0.057	1.993PhePhe: 1.993 ± 0.066	2.534PheGly: 2.534 ± 0.069	0.936PheHis: 0.936 ± 0.035	3.211PheIle: 3.211 ± 0.066	2.807PheLys: 2.807 ± 0.062	4.425PheLeu: 4.425 ± 0.086	1.015PheMet: 1.015 ± 0.04	2.187PheAsn: 2.187 ± 0.055	1.608PhePro: 1.608 ± 0.046	1.62PheGln: 1.62 ± 0.046	1.524PheArg: 1.524 ± 0.045	3.877PheSer: 3.877 ± 0.069	2.127PheThr: 2.127 ± 0.055	2.654PheVal: 2.654 ± 0.059	0.533PheTrp: 0.533 ± 0.023	1.594PheTyr: 1.594 ± 0.043	0.0PheXaa: 0.0 ± 0.0
Gly	4.436GlyAla: 4.436 ± 0.087	0.732GlyCys: 0.732 ± 0.032	2.659GlyAsp: 2.659 ± 0.055	2.982GlyGlu: 2.982 ± 0.063	2.896GlyPhe: 2.896 ± 0.058	3.731GlyGly: 3.731 ± 0.123	1.459GlyHis: 1.459 ± 0.039	4.661GlyIle: 4.661 ± 0.08	3.756GlyLys: 3.756 ± 0.075	6.173GlyLeu: 6.173 ± 0.105	1.646GlyMet: 1.646 ± 0.046	2.352GlyAsn: 2.352 ± 0.07	1.514GlyPro: 1.514 ± 0.047	2.139GlyGln: 2.139 ± 0.049	2.287GlyArg: 2.287 ± 0.056	3.412GlySer: 3.412 ± 0.073	3.003GlyThr: 3.003 ± 0.066	3.84GlyVal: 3.84 ± 0.071	0.803GlyTrp: 0.803 ± 0.031	2.042GlyTyr: 2.042 ± 0.055	0.0GlyXaa: 0.0 ± 0.0
His	1.948HisAla: 1.948 ± 0.049	0.346HisCys: 0.346 ± 0.019	1.147HisAsp: 1.147 ± 0.032	1.378HisGlu: 1.378 ± 0.041	1.337HisPhe: 1.337 ± 0.036	1.296HisGly: 1.296 ± 0.043	0.863HisHis: 0.863 ± 0.042	1.782HisIle: 1.782 ± 0.051	1.394HisLys: 1.394 ± 0.042	2.714HisLeu: 2.714 ± 0.063	0.516HisMet: 0.516 ± 0.027	1.083HisAsn: 1.083 ± 0.036	1.314HisPro: 1.314 ± 0.045	1.24HisGln: 1.24 ± 0.046	1.136HisArg: 1.136 ± 0.042	1.68HisSer: 1.68 ± 0.04	1.219HisThr: 1.219 ± 0.041	1.352HisVal: 1.352 ± 0.044	0.322HisTrp: 0.322 ± 0.019	1.099HisTyr: 1.099 ± 0.042	0.0HisXaa: 0.0 ± 0.0
Ile	6.524IleAla: 6.524 ± 0.081	0.898IleCys: 0.898 ± 0.031	4.436IleAsp: 4.436 ± 0.077	5.472IleGlu: 5.472 ± 0.094	3.063IlePhe: 3.063 ± 0.079	4.35IleGly: 4.35 ± 0.088	1.842IleHis: 1.842 ± 0.048	5.094IleIle: 5.094 ± 0.099	4.917IleLys: 4.917 ± 0.082	7.408IleLeu: 7.408 ± 0.106	1.505IleMet: 1.505 ± 0.044	3.659IleAsn: 3.659 ± 0.074	3.221IlePro: 3.221 ± 0.059	3.352IleGln: 3.352 ± 0.068	2.967IleArg: 2.967 ± 0.065	5.399IleSer: 5.399 ± 0.083	3.928IleThr: 3.928 ± 0.074	4.406IleVal: 4.406 ± 0.074	0.659IleTrp: 0.659 ± 0.031	2.261IleTyr: 2.261 ± 0.058	0.0IleXaa: 0.0 ± 0.0
Lys	5.636LysAla: 5.636 ± 0.098	0.458LysCys: 0.458 ± 0.022	3.603LysAsp: 3.603 ± 0.08	5.035LysGlu: 5.035 ± 0.105	2.017LysPhe: 2.017 ± 0.047	3.417LysGly: 3.417 ± 0.07	1.714LysHis: 1.714 ± 0.045	5.76LysIle: 5.76 ± 0.091	5.305LysLys: 5.305 ± 0.127	6.577LysLeu: 6.577 ± 0.093	1.82LysMet: 1.82 ± 0.043	4.039LysAsn: 4.039 ± 0.081	2.595LysPro: 2.595 ± 0.056	3.437LysGln: 3.437 ± 0.072	3.041LysArg: 3.041 ± 0.069	4.119LysSer: 4.119 ± 0.081	3.683LysThr: 3.683 ± 0.08	3.564LysVal: 3.564 ± 0.075	0.671LysTrp: 0.671 ± 0.03	2.046LysTyr: 2.046 ± 0.052	0.0LysXaa: 0.0 ± 0.0
Leu	8.464LeuAla: 8.464 ± 0.123	1.384LeuCys: 1.384 ± 0.046	5.293LeuAsp: 5.293 ± 0.081	6.683LeuGlu: 6.683 ± 0.108	4.617LeuPhe: 4.617 ± 0.094	6.228LeuGly: 6.228 ± 0.103	2.29LeuHis: 2.29 ± 0.059	6.997LeuIle: 6.997 ± 0.126	7.837LeuLys: 7.837 ± 0.102	10.994LeuLeu: 10.994 ± 0.162	2.629LeuMet: 2.629 ± 0.062	5.476LeuAsn: 5.476 ± 0.095	4.595LeuPro: 4.595 ± 0.089	4.473LeuGln: 4.473 ± 0.082	4.172LeuArg: 4.172 ± 0.08	9.279LeuSer: 9.279 ± 0.144	5.243LeuThr: 5.243 ± 0.099	5.601LeuVal: 5.601 ± 0.092	1.064LeuTrp: 1.064 ± 0.037	3.123LeuTyr: 3.123 ± 0.068	0.0LeuXaa: 0.0 ± 0.0
Met	1.868MetAla: 1.868 ± 0.044	0.194MetCys: 0.194 ± 0.015	1.087MetAsp: 1.087 ± 0.041	1.031MetGlu: 1.031 ± 0.038	0.788MetPhe: 0.788 ± 0.032	1.643MetGly: 1.643 ± 0.048	0.672MetHis: 0.672 ± 0.031	1.741MetIle: 1.741 ± 0.041	1.44MetLys: 1.44 ± 0.051	2.722MetLeu: 2.722 ± 0.065	0.766MetMet: 0.766 ± 0.033	1.245MetAsn: 1.245 ± 0.039	1.225MetPro: 1.225 ± 0.035	1.349MetGln: 1.349 ± 0.041	1.226MetArg: 1.226 ± 0.043	1.69MetSer: 1.69 ± 0.044	1.316MetThr: 1.316 ± 0.041	1.368MetVal: 1.368 ± 0.042	0.153MetTrp: 0.153 ± 0.015	0.529MetTyr: 0.529 ± 0.027	0.0MetXaa: 0.0 ± 0.0
Asn	3.867AsnAla: 3.867 ± 0.069	0.483AsnCys: 0.483 ± 0.022	2.451AsnAsp: 2.451 ± 0.068	2.842AsnGlu: 2.842 ± 0.075	2.1AsnPhe: 2.1 ± 0.056	2.444AsnGly: 2.444 ± 0.075	1.308AsnHis: 1.308 ± 0.04	4.292AsnIle: 4.292 ± 0.083	3.329AsnLys: 3.329 ± 0.071	4.764AsnLeu: 4.764 ± 0.075	1.046AsnMet: 1.046 ± 0.032	2.639AsnAsn: 2.639 ± 0.086	2.36AsnPro: 2.36 ± 0.058	2.482AsnGln: 2.482 ± 0.069	1.978AsnArg: 1.978 ± 0.048	2.506AsnSer: 2.506 ± 0.064	2.707AsnThr: 2.707 ± 0.067	2.597AsnVal: 2.597 ± 0.06	0.562AsnTrp: 0.562 ± 0.027	1.56AsnTyr: 1.56 ± 0.051	0.0AsnXaa: 0.0 ± 0.0
Pro	2.635ProAla: 2.635 ± 0.061	0.342ProCys: 0.342 ± 0.021	1.99ProAsp: 1.99 ± 0.05	3.137ProGlu: 3.137 ± 0.072	1.85ProPhe: 1.85 ± 0.048	2.003ProGly: 2.003 ± 0.052	0.969ProHis: 0.969 ± 0.04	3.042ProIle: 3.042 ± 0.063	2.603ProLys: 2.603 ± 0.054	4.042ProLeu: 4.042 ± 0.075	0.944ProMet: 0.944 ± 0.034	2.018ProAsn: 2.018 ± 0.057	1.423ProPro: 1.423 ± 0.068	1.753ProGln: 1.753 ± 0.048	1.269ProArg: 1.269 ± 0.04	2.696ProSer: 2.696 ± 0.058	2.093ProThr: 2.093 ± 0.053	2.495ProVal: 2.495 ± 0.06	0.415ProTrp: 0.415 ± 0.023	1.337ProTyr: 1.337 ± 0.037	0.0ProXaa: 0.0 ± 0.0
Gln	4.303GlnAla: 4.303 ± 0.081	0.43GlnCys: 0.43 ± 0.021	2.284GlnAsp: 2.284 ± 0.053	2.851GlnGlu: 2.851 ± 0.065	1.853GlnPhe: 1.853 ± 0.048	2.445GlnGly: 2.445 ± 0.055	1.261GlnHis: 1.261 ± 0.042	3.157GlnIle: 3.157 ± 0.063	3.508GlnLys: 3.508 ± 0.078	4.702GlnLeu: 4.702 ± 0.085	1.015GlnMet: 1.015 ± 0.038	2.437GlnAsn: 2.437 ± 0.064	1.574GlnPro: 1.574 ± 0.041	2.561GlnGln: 2.561 ± 0.064	2.099GlnArg: 2.099 ± 0.051	3.393GlnSer: 3.393 ± 0.066	2.353GlnThr: 2.353 ± 0.051	2.338GlnVal: 2.338 ± 0.052	0.467GlnTrp: 0.467 ± 0.022	1.781GlnTyr: 1.781 ± 0.054	0.0GlnXaa: 0.0 ± 0.0
Arg	3.109ArgAla: 3.109 ± 0.068	0.446ArgCys: 0.446 ± 0.023	2.079ArgAsp: 2.079 ± 0.046	2.608ArgGlu: 2.608 ± 0.062	2.035ArgPhe: 2.035 ± 0.048	2.108ArgGly: 2.108 ± 0.056	0.943ArgHis: 0.943 ± 0.035	3.119ArgIle: 3.119 ± 0.06	2.732ArgLys: 2.732 ± 0.06	4.449ArgLeu: 4.449 ± 0.078	1.054ArgMet: 1.054 ± 0.041	1.925ArgAsn: 1.925 ± 0.053	1.378ArgPro: 1.378 ± 0.044	1.842ArgGln: 1.842 ± 0.047	1.892ArgArg: 1.892 ± 0.057	2.507ArgSer: 2.507 ± 0.059	1.863ArgThr: 1.863 ± 0.052	2.484ArgVal: 2.484 ± 0.066	0.502ArgTrp: 0.502 ± 0.025	1.6ArgTyr: 1.6 ± 0.044	0.0ArgXaa: 0.0 ± 0.0
Ser	5.002SerAla: 5.002 ± 0.078	0.7SerCys: 0.7 ± 0.034	3.297SerAsp: 3.297 ± 0.071	4.14SerGlu: 4.14 ± 0.075	3.375SerPhe: 3.375 ± 0.063	3.955SerGly: 3.955 ± 0.097	1.76SerHis: 1.76 ± 0.045	5.364SerIle: 5.364 ± 0.08	4.385SerLys: 4.385 ± 0.083	7.487SerLeu: 7.487 ± 0.115	1.611SerMet: 1.611 ± 0.042	3.071SerAsn: 3.071 ± 0.073	2.569SerPro: 2.569 ± 0.06	3.121SerGln: 3.121 ± 0.068	2.4SerArg: 2.4 ± 0.059	4.819SerSer: 4.819 ± 0.102	3.578SerThr: 3.578 ± 0.069	4.117SerVal: 4.117 ± 0.077	0.667SerTrp: 0.667 ± 0.027	2.204SerTyr: 2.204 ± 0.054	0.0SerXaa: 0.0 ± 0.0
Thr	4.081ThrAla: 4.081 ± 0.084	0.468ThrCys: 0.468 ± 0.023	2.462ThrAsp: 2.462 ± 0.052	3.168ThrGlu: 3.168 ± 0.063	1.947ThrPhe: 1.947 ± 0.045	3.112ThrGly: 3.112 ± 0.068	1.495ThrHis: 1.495 ± 0.046	3.83ThrIle: 3.83 ± 0.078	2.964ThrLys: 2.964 ± 0.07	6.168ThrLeu: 6.168 ± 0.102	1.036ThrMet: 1.036 ± 0.035	1.967ThrAsn: 1.967 ± 0.064	2.641ThrPro: 2.641 ± 0.058	2.712ThrGln: 2.712 ± 0.058	1.909ThrArg: 1.909 ± 0.053	3.038ThrSer: 3.038 ± 0.062	3.035ThrThr: 3.035 ± 0.062	3.27ThrVal: 3.27 ± 0.064	0.453ThrTrp: 0.453 ± 0.02	1.474ThrTyr: 1.474 ± 0.045	0.0ThrXaa: 0.0 ± 0.0
Val	4.898ValAla: 4.898 ± 0.09	0.673ValCys: 0.673 ± 0.027	3.313ValAsp: 3.313 ± 0.082	3.682ValGlu: 3.682 ± 0.079	2.602ValPhe: 2.602 ± 0.067	3.709ValGly: 3.709 ± 0.086	1.287ValHis: 1.287 ± 0.04	4.277ValIle: 4.277 ± 0.076	3.553ValLys: 3.553 ± 0.075	6.228ValLeu: 6.228 ± 0.093	1.51ValMet: 1.51 ± 0.039	2.776ValAsn: 2.776 ± 0.066	2.305ValPro: 2.305 ± 0.054	2.295ValGln: 2.295 ± 0.048	2.323ValArg: 2.323 ± 0.06	4.08ValSer: 4.08 ± 0.078	3.031ValThr: 3.031 ± 0.067	4.142ValVal: 4.142 ± 0.091	0.556ValTrp: 0.556 ± 0.029	1.768ValTyr: 1.768 ± 0.048	0.0ValXaa: 0.0 ± 0.0
Trp	0.694TrpAla: 0.694 ± 0.03	0.134TrpCys: 0.134 ± 0.013	0.479TrpAsp: 0.479 ± 0.024	0.577TrpGlu: 0.577 ± 0.026	0.546TrpPhe: 0.546 ± 0.029	0.68TrpGly: 0.68 ± 0.028	0.367TrpHis: 0.367 ± 0.021	0.851TrpIle: 0.851 ± 0.032	0.513TrpLys: 0.513 ± 0.023	1.367TrpLeu: 1.367 ± 0.049	0.328TrpMet: 0.328 ± 0.02	0.397TrpAsn: 0.397 ± 0.023	0.389TrpPro: 0.389 ± 0.02	0.697TrpGln: 0.697 ± 0.035	0.497TrpArg: 0.497 ± 0.023	0.572TrpSer: 0.572 ± 0.024	0.375TrpThr: 0.375 ± 0.02	0.697TrpVal: 0.697 ± 0.03	0.135TrpTrp: 0.135 ± 0.014	0.412TrpTyr: 0.412 ± 0.027	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.448TyrAla: 2.448 ± 0.058	0.49TyrCys: 0.49 ± 0.025	1.651TyrAsp: 1.651 ± 0.042	1.862TyrGlu: 1.862 ± 0.05	1.812TyrPhe: 1.812 ± 0.052	1.964TyrGly: 1.964 ± 0.048	1.05TyrHis: 1.05 ± 0.036	2.071TyrIle: 2.071 ± 0.054	1.816TyrLys: 1.816 ± 0.051	3.804TyrLeu: 3.804 ± 0.071	0.581TyrMet: 0.581 ± 0.024	1.351TyrAsn: 1.351 ± 0.044	1.366TyrPro: 1.366 ± 0.043	2.073TyrGln: 2.073 ± 0.055	1.482TyrArg: 1.482 ± 0.045	2.105TyrSer: 2.105 ± 0.059	1.58TyrThr: 1.58 ± 0.046	1.729TyrVal: 1.729 ± 0.048	0.454TyrTrp: 0.454 ± 0.029	1.408TyrTyr: 1.408 ± 0.053	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2537 proteins (872039 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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