Amino acid dipepetide frequency for Umezawaea tangerina

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	19.567AlaAla: 19.567 ± 0.128	0.983AlaCys: 0.983 ± 0.019	8.762AlaAsp: 8.762 ± 0.067	8.326AlaGlu: 8.326 ± 0.062	3.737AlaPhe: 3.737 ± 0.039	12.328AlaGly: 12.328 ± 0.063	2.837AlaHis: 2.837 ± 0.035	3.68AlaIle: 3.68 ± 0.036	2.866AlaLys: 2.866 ± 0.038	14.633AlaLeu: 14.633 ± 0.092	2.414AlaMet: 2.414 ± 0.028	2.353AlaAsn: 2.353 ± 0.033	6.099AlaPro: 6.099 ± 0.069	3.267AlaGln: 3.267 ± 0.033	9.286AlaArg: 9.286 ± 0.074	5.8AlaSer: 5.8 ± 0.046	7.366AlaThr: 7.366 ± 0.049	13.428AlaVal: 13.428 ± 0.077	1.807AlaTrp: 1.807 ± 0.025	2.251AlaTyr: 2.251 ± 0.027	0.0AlaXaa: 0.0 ± 0.0
Cys	1.039CysAla: 1.039 ± 0.021	0.087CysCys: 0.087 ± 0.006	0.466CysAsp: 0.466 ± 0.013	0.352CysGlu: 0.352 ± 0.01	0.195CysPhe: 0.195 ± 0.008	0.881CysGly: 0.881 ± 0.021	0.173CysHis: 0.173 ± 0.008	0.112CysIle: 0.112 ± 0.007	0.119CysLys: 0.119 ± 0.007	0.724CysLeu: 0.724 ± 0.018	0.105CysMet: 0.105 ± 0.006	0.138CysAsn: 0.138 ± 0.008	0.45CysPro: 0.45 ± 0.011	0.153CysGln: 0.153 ± 0.008	0.544CysArg: 0.544 ± 0.013	0.438CysSer: 0.438 ± 0.013	0.474CysThr: 0.474 ± 0.014	0.669CysVal: 0.669 ± 0.017	0.118CysTrp: 0.118 ± 0.007	0.153CysTyr: 0.153 ± 0.007	0.0CysXaa: 0.0 ± 0.0
Asp	7.442AspAla: 7.442 ± 0.062	0.418AspCys: 0.418 ± 0.011	4.088AspAsp: 4.088 ± 0.041	3.963AspGlu: 3.963 ± 0.036	1.737AspPhe: 1.737 ± 0.023	6.527AspGly: 6.527 ± 0.057	1.658AspHis: 1.658 ± 0.024	1.624AspIle: 1.624 ± 0.026	1.121AspLys: 1.121 ± 0.023	7.371AspLeu: 7.371 ± 0.054	0.733AspMet: 0.733 ± 0.017	1.114AspAsn: 1.114 ± 0.019	4.556AspPro: 4.556 ± 0.04	1.764AspGln: 1.764 ± 0.026	5.485AspArg: 5.485 ± 0.053	2.7AspSer: 2.7 ± 0.029	3.107AspThr: 3.107 ± 0.033	6.133AspVal: 6.133 ± 0.044	1.06AspTrp: 1.06 ± 0.019	1.237AspTyr: 1.237 ± 0.023	0.0AspXaa: 0.0 ± 0.0
Glu	6.577GluAla: 6.577 ± 0.06	0.36GluCys: 0.36 ± 0.011	2.749GluAsp: 2.749 ± 0.033	2.828GluGlu: 2.828 ± 0.035	1.602GluPhe: 1.602 ± 0.027	3.65GluGly: 3.65 ± 0.037	1.683GluHis: 1.683 ± 0.026	1.92GluIle: 1.92 ± 0.028	1.084GluLys: 1.084 ± 0.024	7.026GluLeu: 7.026 ± 0.055	0.771GluMet: 0.771 ± 0.016	0.929GluAsn: 0.929 ± 0.017	3.185GluPro: 3.185 ± 0.039	2.102GluGln: 2.102 ± 0.033	4.855GluArg: 4.855 ± 0.047	2.543GluSer: 2.543 ± 0.028	2.373GluThr: 2.373 ± 0.03	5.486GluVal: 5.486 ± 0.046	0.773GluTrp: 0.773 ± 0.016	0.984GluTyr: 0.984 ± 0.019	0.0GluXaa: 0.0 ± 0.0
Phe	3.978PheAla: 3.978 ± 0.039	0.253PheCys: 0.253 ± 0.011	2.332PheAsp: 2.332 ± 0.029	1.387PheGlu: 1.387 ± 0.022	0.857PhePhe: 0.857 ± 0.017	3.294PheGly: 3.294 ± 0.031	0.656PheHis: 0.656 ± 0.014	0.651PheIle: 0.651 ± 0.015	0.438PheLys: 0.438 ± 0.012	2.703PheLeu: 2.703 ± 0.032	0.343PheMet: 0.343 ± 0.01	0.5PheAsn: 0.5 ± 0.013	1.497PhePro: 1.497 ± 0.023	0.714PheGln: 0.714 ± 0.016	1.967PheArg: 1.967 ± 0.024	1.508PheSer: 1.508 ± 0.024	2.17PheThr: 2.17 ± 0.027	2.48PheVal: 2.48 ± 0.028	0.41PheTrp: 0.41 ± 0.012	0.565PheTyr: 0.565 ± 0.013	0.0PheXaa: 0.0 ± 0.0
Gly	10.268GlyAla: 10.268 ± 0.067	0.787GlyCys: 0.787 ± 0.017	5.303GlyAsp: 5.303 ± 0.051	4.704GlyGlu: 4.704 ± 0.043	3.075GlyPhe: 3.075 ± 0.03	8.605GlyGly: 8.605 ± 0.083	2.27GlyHis: 2.27 ± 0.029	3.263GlyIle: 3.263 ± 0.039	2.366GlyLys: 2.366 ± 0.033	9.675GlyLeu: 9.675 ± 0.069	2.058GlyMet: 2.058 ± 0.026	1.804GlyAsn: 1.804 ± 0.032	4.757GlyPro: 4.757 ± 0.041	2.565GlyGln: 2.565 ± 0.032	7.123GlyArg: 7.123 ± 0.05	5.234GlySer: 5.234 ± 0.052	6.273GlyThr: 6.273 ± 0.055	8.953GlyVal: 8.953 ± 0.065	1.741GlyTrp: 1.741 ± 0.025	2.278GlyTyr: 2.278 ± 0.031	0.0GlyXaa: 0.0 ± 0.0
His	2.602HisAla: 2.602 ± 0.034	0.191HisCys: 0.191 ± 0.007	1.565HisAsp: 1.565 ± 0.023	1.255HisGlu: 1.255 ± 0.021	0.655HisPhe: 0.655 ± 0.014	2.31HisGly: 2.31 ± 0.029	0.713HisHis: 0.713 ± 0.018	0.508HisIle: 0.508 ± 0.013	0.309HisLys: 0.309 ± 0.01	2.602HisLeu: 2.602 ± 0.03	0.258HisMet: 0.258 ± 0.009	0.396HisAsn: 0.396 ± 0.013	1.767HisPro: 1.767 ± 0.029	0.645HisGln: 0.645 ± 0.013	2.092HisArg: 2.092 ± 0.029	1.007HisSer: 1.007 ± 0.02	1.151HisThr: 1.151 ± 0.022	2.128HisVal: 2.128 ± 0.025	0.353HisTrp: 0.353 ± 0.012	0.473HisTyr: 0.473 ± 0.013	0.0HisXaa: 0.0 ± 0.0
Ile	4.755IleAla: 4.755 ± 0.041	0.229IleCys: 0.229 ± 0.009	2.038IleAsp: 2.038 ± 0.026	1.643IleGlu: 1.643 ± 0.026	0.599IlePhe: 0.599 ± 0.013	3.586IleGly: 3.586 ± 0.034	0.497IleHis: 0.497 ± 0.011	0.731IleIle: 0.731 ± 0.016	0.617IleLys: 0.617 ± 0.015	1.935IleLeu: 1.935 ± 0.029	0.392IleMet: 0.392 ± 0.01	0.584IleAsn: 0.584 ± 0.015	1.681IlePro: 1.681 ± 0.024	0.601IleGln: 0.601 ± 0.015	2.132IleArg: 2.132 ± 0.03	1.677IleSer: 1.677 ± 0.026	2.291IleThr: 2.291 ± 0.029	2.425IleVal: 2.425 ± 0.033	0.323IleTrp: 0.323 ± 0.012	0.442IleTyr: 0.442 ± 0.012	0.0IleXaa: 0.0 ± 0.0
Lys	2.701LysAla: 2.701 ± 0.041	0.111LysCys: 0.111 ± 0.006	1.054LysAsp: 1.054 ± 0.019	0.877LysGlu: 0.877 ± 0.02	0.48LysPhe: 0.48 ± 0.012	1.534LysGly: 1.534 ± 0.027	0.431LysHis: 0.431 ± 0.01	0.753LysIle: 0.753 ± 0.017	0.517LysLys: 0.517 ± 0.017	2.042LysLeu: 2.042 ± 0.031	0.327LysMet: 0.327 ± 0.01	0.413LysAsn: 0.413 ± 0.012	1.361LysPro: 1.361 ± 0.025	0.637LysGln: 0.637 ± 0.016	1.381LysArg: 1.381 ± 0.024	1.119LysSer: 1.119 ± 0.022	1.192LysThr: 1.192 ± 0.023	2.015LysVal: 2.015 ± 0.03	0.301LysTrp: 0.301 ± 0.011	0.397LysTyr: 0.397 ± 0.01	0.0LysXaa: 0.0 ± 0.0
Leu	15.628LeuAla: 15.628 ± 0.098	0.786LeuCys: 0.786 ± 0.018	7.454LeuAsp: 7.454 ± 0.056	4.595LeuGlu: 4.595 ± 0.043	2.768LeuPhe: 2.768 ± 0.03	9.649LeuGly: 9.649 ± 0.061	2.464LeuHis: 2.464 ± 0.032	2.645LeuIle: 2.645 ± 0.03	1.714LeuLys: 1.714 ± 0.029	11.41LeuLeu: 11.41 ± 0.086	1.429LeuMet: 1.429 ± 0.025	1.651LeuAsn: 1.651 ± 0.024	6.362LeuPro: 6.362 ± 0.05	1.959LeuGln: 1.959 ± 0.026	8.998LeuArg: 8.998 ± 0.067	5.527LeuSer: 5.527 ± 0.044	6.53LeuThr: 6.53 ± 0.048	11.342LeuVal: 11.342 ± 0.083	1.291LeuTrp: 1.291 ± 0.021	1.624LeuTyr: 1.624 ± 0.023	0.0LeuXaa: 0.0 ± 0.0
Met	2.159MetAla: 2.159 ± 0.028	0.116MetCys: 0.116 ± 0.007	0.828MetAsp: 0.828 ± 0.017	0.596MetGlu: 0.596 ± 0.014	0.456MetPhe: 0.456 ± 0.012	1.238MetGly: 1.238 ± 0.021	0.322MetHis: 0.322 ± 0.011	0.622MetIle: 0.622 ± 0.016	0.339MetLys: 0.339 ± 0.011	1.625MetLeu: 1.625 ± 0.023	0.241MetMet: 0.241 ± 0.009	0.376MetAsn: 0.376 ± 0.01	1.026MetPro: 1.026 ± 0.018	0.366MetGln: 0.366 ± 0.012	1.4MetArg: 1.4 ± 0.022	1.276MetSer: 1.276 ± 0.02	1.494MetThr: 1.494 ± 0.023	1.427MetVal: 1.427 ± 0.022	0.196MetTrp: 0.196 ± 0.008	0.23MetTyr: 0.23 ± 0.009	0.0MetXaa: 0.0 ± 0.0
Asn	2.41AsnAla: 2.41 ± 0.031	0.16AsnCys: 0.16 ± 0.008	0.982AsnAsp: 0.982 ± 0.019	0.757AsnGlu: 0.757 ± 0.016	0.489AsnPhe: 0.489 ± 0.015	2.116AsnGly: 2.116 ± 0.036	0.406AsnHis: 0.406 ± 0.012	0.569AsnIle: 0.569 ± 0.014	0.371AsnLys: 0.371 ± 0.012	1.765AsnLeu: 1.765 ± 0.026	0.252AsnMet: 0.252 ± 0.009	0.468AsnAsn: 0.468 ± 0.014	1.473AsnPro: 1.473 ± 0.026	0.548AsnGln: 0.548 ± 0.014	1.352AsnArg: 1.352 ± 0.021	0.95AsnSer: 0.95 ± 0.02	1.184AsnThr: 1.184 ± 0.024	1.423AsnVal: 1.423 ± 0.026	0.27AsnTrp: 0.27 ± 0.011	0.419AsnTyr: 0.419 ± 0.012	0.0AsnXaa: 0.0 ± 0.0
Pro	7.595ProAla: 7.595 ± 0.074	0.314ProCys: 0.314 ± 0.011	4.757ProAsp: 4.757 ± 0.042	3.959ProGlu: 3.959 ± 0.044	1.602ProPhe: 1.602 ± 0.021	5.772ProGly: 5.772 ± 0.055	1.24ProHis: 1.24 ± 0.022	1.458ProIle: 1.458 ± 0.021	1.149ProLys: 1.149 ± 0.025	5.192ProLeu: 5.192 ± 0.046	0.991ProMet: 0.991 ± 0.017	1.113ProAsn: 1.113 ± 0.022	3.494ProPro: 3.494 ± 0.053	1.38ProGln: 1.38 ± 0.028	3.701ProArg: 3.701 ± 0.041	3.177ProSer: 3.177 ± 0.035	3.648ProThr: 3.648 ± 0.04	6.044ProVal: 6.044 ± 0.049	0.91ProTrp: 0.91 ± 0.016	0.969ProTyr: 0.969 ± 0.018	0.0ProXaa: 0.0 ± 0.0
Gln	3.431GlnAla: 3.431 ± 0.042	0.155GlnCys: 0.155 ± 0.008	1.397GlnAsp: 1.397 ± 0.021	1.261GlnGlu: 1.261 ± 0.02	0.709GlnPhe: 0.709 ± 0.015	2.055GlnGly: 2.055 ± 0.031	0.601GlnHis: 0.601 ± 0.016	0.847GlnIle: 0.847 ± 0.017	0.457GlnLys: 0.457 ± 0.016	2.827GlnLeu: 2.827 ± 0.032	0.353GlnMet: 0.353 ± 0.011	0.497GlnAsn: 0.497 ± 0.014	1.578GlnPro: 1.578 ± 0.027	1.082GlnGln: 1.082 ± 0.023	2.35GlnArg: 2.35 ± 0.03	1.173GlnSer: 1.173 ± 0.022	1.2GlnThr: 1.2 ± 0.022	2.675GlnVal: 2.675 ± 0.032	0.46GlnTrp: 0.46 ± 0.012	0.522GlnTyr: 0.522 ± 0.015	0.0GlnXaa: 0.0 ± 0.0
Arg	9.467ArgAla: 9.467 ± 0.067	0.571ArgCys: 0.571 ± 0.015	4.435ArgAsp: 4.435 ± 0.041	4.418ArgGlu: 4.418 ± 0.047	2.581ArgPhe: 2.581 ± 0.031	5.974ArgGly: 5.974 ± 0.046	1.934ArgHis: 1.934 ± 0.029	2.894ArgIle: 2.894 ± 0.035	1.697ArgLys: 1.697 ± 0.025	8.534ArgLeu: 8.534 ± 0.061	1.808ArgMet: 1.808 ± 0.024	1.353ArgAsn: 1.353 ± 0.022	4.448ArgPro: 4.448 ± 0.043	2.147ArgGln: 2.147 ± 0.024	7.185ArgArg: 7.185 ± 0.066	4.139ArgSer: 4.139 ± 0.035	5.123ArgThr: 5.123 ± 0.041	6.781ArgVal: 6.781 ± 0.053	1.446ArgTrp: 1.446 ± 0.023	1.765ArgTyr: 1.765 ± 0.025	0.0ArgXaa: 0.0 ± 0.0
Ser	6.872SerAla: 6.872 ± 0.052	0.387SerCys: 0.387 ± 0.011	2.768SerAsp: 2.768 ± 0.031	2.213SerGlu: 2.213 ± 0.031	1.597SerPhe: 1.597 ± 0.028	5.945SerGly: 5.945 ± 0.052	0.954SerHis: 0.954 ± 0.018	1.573SerIle: 1.573 ± 0.025	0.99SerLys: 0.99 ± 0.023	4.92SerLeu: 4.92 ± 0.048	1.051SerMet: 1.051 ± 0.018	0.925SerAsn: 0.925 ± 0.02	3.175SerPro: 3.175 ± 0.042	1.178SerGln: 1.178 ± 0.022	3.64SerArg: 3.64 ± 0.033	3.172SerSer: 3.172 ± 0.039	3.835SerThr: 3.835 ± 0.046	4.601SerVal: 4.601 ± 0.04	1.007SerTrp: 1.007 ± 0.018	1.112SerTyr: 1.112 ± 0.02	0.0SerXaa: 0.0 ± 0.0
Thr	9.018ThrAla: 9.018 ± 0.053	0.457ThrCys: 0.457 ± 0.011	3.622ThrAsp: 3.622 ± 0.04	2.945ThrGlu: 2.945 ± 0.035	1.677ThrPhe: 1.677 ± 0.028	6.887ThrGly: 6.887 ± 0.065	1.121ThrHis: 1.121 ± 0.022	1.931ThrIle: 1.931 ± 0.031	1.199ThrLys: 1.199 ± 0.024	5.23ThrLeu: 5.23 ± 0.045	0.986ThrMet: 0.986 ± 0.019	1.163ThrAsn: 1.163 ± 0.022	4.112ThrPro: 4.112 ± 0.048	1.224ThrGln: 1.224 ± 0.021	4.141ThrArg: 4.141 ± 0.041	3.723ThrSer: 3.723 ± 0.04	5.025ThrThr: 5.025 ± 0.071	5.797ThrVal: 5.797 ± 0.046	1.011ThrTrp: 1.011 ± 0.02	1.221ThrTyr: 1.221 ± 0.021	0.0ThrXaa: 0.0 ± 0.0
Val	12.45ValAla: 12.45 ± 0.08	0.722ValCys: 0.722 ± 0.015	7.1ValAsp: 7.1 ± 0.054	5.764ValGlu: 5.764 ± 0.048	2.738ValPhe: 2.738 ± 0.031	7.847ValGly: 7.847 ± 0.07	2.234ValHis: 2.234 ± 0.027	2.574ValIle: 2.574 ± 0.031	1.681ValLys: 1.681 ± 0.027	11.603ValLeu: 11.603 ± 0.086	1.333ValMet: 1.333 ± 0.022	1.807ValAsn: 1.807 ± 0.03	5.57ValPro: 5.57 ± 0.048	2.144ValGln: 2.144 ± 0.033	7.812ValArg: 7.812 ± 0.054	4.671ValSer: 4.671 ± 0.042	5.799ValThr: 5.799 ± 0.049	11.464ValVal: 11.464 ± 0.085	1.134ValTrp: 1.134 ± 0.021	1.515ValTyr: 1.515 ± 0.021	0.0ValXaa: 0.0 ± 0.0
Trp	1.6TrpAla: 1.6 ± 0.025	0.148TrpCys: 0.148 ± 0.007	0.87TrpAsp: 0.87 ± 0.019	0.688TrpGlu: 0.688 ± 0.015	0.518TrpPhe: 0.518 ± 0.014	1.077TrpGly: 1.077 ± 0.026	0.384TrpHis: 0.384 ± 0.012	0.452TrpIle: 0.452 ± 0.013	0.31TrpLys: 0.31 ± 0.01	1.809TrpLeu: 1.809 ± 0.025	0.301TrpMet: 0.301 ± 0.01	0.39TrpAsn: 0.39 ± 0.012	0.805TrpPro: 0.805 ± 0.017	0.553TrpGln: 0.553 ± 0.015	1.405TrpArg: 1.405 ± 0.021	1.059TrpSer: 1.059 ± 0.018	1.107TrpThr: 1.107 ± 0.022	1.171TrpVal: 1.171 ± 0.02	0.344TrpTrp: 0.344 ± 0.011	0.308TrpTyr: 0.308 ± 0.01	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.23TyrAla: 2.23 ± 0.024	0.155TyrCys: 0.155 ± 0.007	1.264TyrAsp: 1.264 ± 0.021	0.951TyrGlu: 0.951 ± 0.017	0.632TyrPhe: 0.632 ± 0.016	1.825TyrGly: 1.825 ± 0.026	0.403TyrHis: 0.403 ± 0.012	0.368TyrIle: 0.368 ± 0.011	0.299TyrLys: 0.299 ± 0.011	2.201TyrLeu: 2.201 ± 0.03	0.186TyrMet: 0.186 ± 0.008	0.392TyrAsn: 0.392 ± 0.013	1.068TyrPro: 1.068 ± 0.018	0.601TyrGln: 0.601 ± 0.015	1.851TyrArg: 1.851 ± 0.027	1.024TyrSer: 1.024 ± 0.02	1.149TyrThr: 1.149 ± 0.022	1.521TyrVal: 1.521 ± 0.024	0.346TyrTrp: 0.346 ± 0.011	0.445TyrTyr: 0.445 ± 0.011	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 9362 proteins (3192573 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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