Amino acid dipepetide frequency for Streptococcus phage Javan573

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
4.407AlaAla: 4.407 ± 0.902
0.691AlaCys: 0.691 ± 0.294
4.839AlaAsp: 4.839 ± 0.6
6.049AlaGlu: 6.049 ± 0.84
2.679AlaPhe: 2.679 ± 0.471
5.271AlaGly: 5.271 ± 0.977
1.21AlaHis: 1.21 ± 0.366
7.086AlaIle: 7.086 ± 1.307
6.395AlaLys: 6.395 ± 0.854
5.358AlaLeu: 5.358 ± 0.712
2.074AlaMet: 2.074 ± 0.459
3.629AlaAsn: 3.629 ± 0.577
1.21AlaPro: 1.21 ± 0.298
3.111AlaGln: 3.111 ± 0.636
3.457AlaArg: 3.457 ± 0.529
4.321AlaSer: 4.321 ± 0.595
3.197AlaThr: 3.197 ± 0.568
6.049AlaVal: 6.049 ± 1.192
1.555AlaTrp: 1.555 ± 0.595
2.765AlaTyr: 2.765 ± 0.52
0.0AlaXaa: 0.0 ± 0.0
Cys
0.173CysAla: 0.173 ± 0.118
0.0CysCys: 0.0 ± 0.0
0.173CysAsp: 0.173 ± 0.122
0.346CysGlu: 0.346 ± 0.146
0.086CysPhe: 0.086 ± 0.104
0.259CysGly: 0.259 ± 0.16
0.0CysHis: 0.0 ± 0.0
0.086CysIle: 0.086 ± 0.092
0.432CysLys: 0.432 ± 0.238
0.432CysLeu: 0.432 ± 0.25
0.0CysMet: 0.0 ± 0.0
0.173CysAsn: 0.173 ± 0.107
0.173CysPro: 0.173 ± 0.132
0.173CysGln: 0.173 ± 0.115
0.259CysArg: 0.259 ± 0.143
0.518CysSer: 0.518 ± 0.234
0.086CysThr: 0.086 ± 0.077
0.518CysVal: 0.518 ± 0.188
0.0CysTrp: 0.0 ± 0.0
0.173CysTyr: 0.173 ± 0.124
0.0CysXaa: 0.0 ± 0.0
Asp
4.58AspAla: 4.58 ± 0.768
0.432AspCys: 0.432 ± 0.171
3.025AspAsp: 3.025 ± 0.64
5.012AspGlu: 5.012 ± 0.877
3.025AspPhe: 3.025 ± 0.515
4.321AspGly: 4.321 ± 0.728
0.518AspHis: 0.518 ± 0.18
4.58AspIle: 4.58 ± 0.714
6.308AspLys: 6.308 ± 0.915
4.926AspLeu: 4.926 ± 0.491
1.296AspMet: 1.296 ± 0.305
4.234AspAsn: 4.234 ± 0.579
1.901AspPro: 1.901 ± 0.425
1.642AspGln: 1.642 ± 0.363
2.592AspArg: 2.592 ± 0.482
3.889AspSer: 3.889 ± 0.541
3.284AspThr: 3.284 ± 0.607
3.629AspVal: 3.629 ± 0.56
1.123AspTrp: 1.123 ± 0.248
3.197AspTyr: 3.197 ± 0.585
0.0AspXaa: 0.0 ± 0.0
Glu
7.432GluAla: 7.432 ± 0.699
0.086GluCys: 0.086 ± 0.077
3.629GluAsp: 3.629 ± 0.523
5.012GluGlu: 5.012 ± 0.723
1.988GluPhe: 1.988 ± 0.361
3.457GluGly: 3.457 ± 0.597
1.296GluHis: 1.296 ± 0.345
7.432GluIle: 7.432 ± 0.79
5.358GluLys: 5.358 ± 0.941
7.086GluLeu: 7.086 ± 0.908
3.197GluMet: 3.197 ± 0.502
4.148GluAsn: 4.148 ± 0.48
2.074GluPro: 2.074 ± 0.53
3.284GluGln: 3.284 ± 0.529
2.852GluArg: 2.852 ± 0.558
3.457GluSer: 3.457 ± 0.584
4.321GluThr: 4.321 ± 0.688
5.012GluVal: 5.012 ± 0.968
1.555GluTrp: 1.555 ± 0.335
2.679GluTyr: 2.679 ± 0.574
0.0GluXaa: 0.0 ± 0.0
Phe
2.506PheAla: 2.506 ± 0.474
0.0PheCys: 0.0 ± 0.0
3.111PheAsp: 3.111 ± 0.583
2.852PheGlu: 2.852 ± 0.627
1.21PhePhe: 1.21 ± 0.353
2.506PheGly: 2.506 ± 0.356
0.346PheHis: 0.346 ± 0.138
2.247PheIle: 2.247 ± 0.46
2.16PheLys: 2.16 ± 0.386
2.333PheLeu: 2.333 ± 0.406
0.778PheMet: 0.778 ± 0.286
1.815PheAsn: 1.815 ± 0.416
0.432PhePro: 0.432 ± 0.219
0.951PheGln: 0.951 ± 0.295
2.333PheArg: 2.333 ± 0.47
2.938PheSer: 2.938 ± 0.455
2.852PheThr: 2.852 ± 0.459
2.679PheVal: 2.679 ± 0.462
0.259PheTrp: 0.259 ± 0.184
1.555PheTyr: 1.555 ± 0.375
0.0PheXaa: 0.0 ± 0.0
Gly
4.494GlyAla: 4.494 ± 0.896
0.173GlyCys: 0.173 ± 0.11
3.716GlyAsp: 3.716 ± 0.556
3.716GlyGlu: 3.716 ± 0.497
2.42GlyPhe: 2.42 ± 0.599
4.234GlyGly: 4.234 ± 0.797
1.383GlyHis: 1.383 ± 0.317
4.926GlyIle: 4.926 ± 0.699
5.79GlyLys: 5.79 ± 0.856
4.753GlyLeu: 4.753 ± 0.849
1.728GlyMet: 1.728 ± 0.474
2.247GlyAsn: 2.247 ± 0.443
1.123GlyPro: 1.123 ± 0.262
3.111GlyGln: 3.111 ± 0.427
3.197GlyArg: 3.197 ± 0.53
3.975GlySer: 3.975 ± 0.669
4.234GlyThr: 4.234 ± 0.911
3.975GlyVal: 3.975 ± 0.616
0.518GlyTrp: 0.518 ± 0.168
3.284GlyTyr: 3.284 ± 0.497
0.0GlyXaa: 0.0 ± 0.0
His
0.691HisAla: 0.691 ± 0.276
0.173HisCys: 0.173 ± 0.123
1.21HisAsp: 1.21 ± 0.324
1.21HisGlu: 1.21 ± 0.382
0.951HisPhe: 0.951 ± 0.309
1.123HisGly: 1.123 ± 0.268
0.173HisHis: 0.173 ± 0.161
0.864HisIle: 0.864 ± 0.338
0.864HisLys: 0.864 ± 0.274
0.605HisLeu: 0.605 ± 0.257
0.432HisMet: 0.432 ± 0.193
0.864HisAsn: 0.864 ± 0.334
0.951HisPro: 0.951 ± 0.311
0.173HisGln: 0.173 ± 0.142
0.691HisArg: 0.691 ± 0.245
0.778HisSer: 0.778 ± 0.258
0.864HisThr: 0.864 ± 0.294
0.778HisVal: 0.778 ± 0.226
0.086HisTrp: 0.086 ± 0.073
0.778HisTyr: 0.778 ± 0.3
0.0HisXaa: 0.0 ± 0.0
Ile
4.234IleAla: 4.234 ± 0.561
0.259IleCys: 0.259 ± 0.142
5.099IleAsp: 5.099 ± 0.613
5.617IleGlu: 5.617 ± 0.588
2.506IlePhe: 2.506 ± 0.45
4.062IleGly: 4.062 ± 0.714
1.21IleHis: 1.21 ± 0.381
2.938IleIle: 2.938 ± 0.581
7.691IleLys: 7.691 ± 1.094
5.012IleLeu: 5.012 ± 0.583
1.123IleMet: 1.123 ± 0.308
3.025IleAsn: 3.025 ± 0.612
2.074IlePro: 2.074 ± 0.352
3.629IleGln: 3.629 ± 0.704
2.42IleArg: 2.42 ± 0.379
5.358IleSer: 5.358 ± 0.831
5.012IleThr: 5.012 ± 1.126
4.148IleVal: 4.148 ± 0.847
1.21IleTrp: 1.21 ± 0.717
3.37IleTyr: 3.37 ± 0.553
0.0IleXaa: 0.0 ± 0.0
Lys
6.481LysAla: 6.481 ± 0.812
0.259LysCys: 0.259 ± 0.149
4.58LysAsp: 4.58 ± 0.747
6.308LysGlu: 6.308 ± 1.017
2.333LysPhe: 2.333 ± 0.499
5.012LysGly: 5.012 ± 0.747
1.21LysHis: 1.21 ± 0.528
5.703LysIle: 5.703 ± 1.013
6.827LysLys: 6.827 ± 1.171
5.099LysLeu: 5.099 ± 0.654
2.074LysMet: 2.074 ± 0.682
4.666LysAsn: 4.666 ± 0.519
3.111LysPro: 3.111 ± 0.446
4.148LysGln: 4.148 ± 0.782
3.457LysArg: 3.457 ± 0.616
4.321LysSer: 4.321 ± 0.578
5.876LysThr: 5.876 ± 0.632
6.913LysVal: 6.913 ± 0.759
1.21LysTrp: 1.21 ± 0.283
2.765LysTyr: 2.765 ± 0.499
0.0LysXaa: 0.0 ± 0.0
Leu
5.963LeuAla: 5.963 ± 0.726
0.432LeuCys: 0.432 ± 0.175
6.481LeuAsp: 6.481 ± 1.017
6.568LeuGlu: 6.568 ± 0.848
2.679LeuPhe: 2.679 ± 0.564
4.58LeuGly: 4.58 ± 0.718
1.123LeuHis: 1.123 ± 0.276
4.926LeuIle: 4.926 ± 0.724
7.172LeuLys: 7.172 ± 0.845
5.531LeuLeu: 5.531 ± 0.669
1.037LeuMet: 1.037 ± 0.249
4.321LeuAsn: 4.321 ± 0.535
2.592LeuPro: 2.592 ± 0.395
3.284LeuGln: 3.284 ± 0.437
3.543LeuArg: 3.543 ± 0.557
4.148LeuSer: 4.148 ± 0.52
5.963LeuThr: 5.963 ± 0.692
5.185LeuVal: 5.185 ± 0.521
0.778LeuTrp: 0.778 ± 0.24
1.296LeuTyr: 1.296 ± 0.312
0.0LeuXaa: 0.0 ± 0.0
Met
1.988MetAla: 1.988 ± 0.521
0.0MetCys: 0.0 ± 0.0
1.815MetAsp: 1.815 ± 0.385
1.988MetGlu: 1.988 ± 0.509
0.951MetPhe: 0.951 ± 0.258
0.951MetGly: 0.951 ± 0.268
0.346MetHis: 0.346 ± 0.193
1.728MetIle: 1.728 ± 0.426
2.333MetLys: 2.333 ± 0.593
1.988MetLeu: 1.988 ± 0.426
0.346MetMet: 0.346 ± 0.166
1.21MetAsn: 1.21 ± 0.416
0.259MetPro: 0.259 ± 0.136
0.864MetGln: 0.864 ± 0.231
1.21MetArg: 1.21 ± 0.316
1.383MetSer: 1.383 ± 0.329
2.506MetThr: 2.506 ± 0.404
1.383MetVal: 1.383 ± 0.402
0.259MetTrp: 0.259 ± 0.153
0.432MetTyr: 0.432 ± 0.2
0.0MetXaa: 0.0 ± 0.0
Asn
4.753AsnAla: 4.753 ± 1.143
0.346AsnCys: 0.346 ± 0.166
2.506AsnAsp: 2.506 ± 0.567
3.543AsnGlu: 3.543 ± 0.504
1.901AsnPhe: 1.901 ± 0.295
5.358AsnGly: 5.358 ± 0.798
0.518AsnHis: 0.518 ± 0.213
3.716AsnIle: 3.716 ± 0.565
3.629AsnLys: 3.629 ± 0.669
4.407AsnLeu: 4.407 ± 0.655
0.951AsnMet: 0.951 ± 0.319
3.716AsnAsn: 3.716 ± 0.766
1.642AsnPro: 1.642 ± 0.352
2.852AsnGln: 2.852 ± 0.52
3.284AsnArg: 3.284 ± 0.616
3.025AsnSer: 3.025 ± 0.585
2.679AsnThr: 2.679 ± 0.405
2.938AsnVal: 2.938 ± 0.624
0.691AsnTrp: 0.691 ± 0.233
2.074AsnTyr: 2.074 ± 0.451
0.0AsnXaa: 0.0 ± 0.0
Pro
1.642ProAla: 1.642 ± 0.388
0.259ProCys: 0.259 ± 0.154
1.642ProAsp: 1.642 ± 0.469
2.247ProGlu: 2.247 ± 0.425
0.864ProPhe: 0.864 ± 0.269
1.037ProGly: 1.037 ± 0.337
0.518ProHis: 0.518 ± 0.215
1.901ProIle: 1.901 ± 0.367
2.852ProLys: 2.852 ± 0.574
1.815ProLeu: 1.815 ± 0.421
0.778ProMet: 0.778 ± 0.289
2.16ProAsn: 2.16 ± 0.421
0.086ProPro: 0.086 ± 0.088
1.123ProGln: 1.123 ± 0.297
1.037ProArg: 1.037 ± 0.336
2.333ProSer: 2.333 ± 0.491
1.123ProThr: 1.123 ± 0.312
1.988ProVal: 1.988 ± 0.37
0.173ProTrp: 0.173 ± 0.094
0.951ProTyr: 0.951 ± 0.255
0.0ProXaa: 0.0 ± 0.0
Gln
3.975GlnAla: 3.975 ± 0.499
0.346GlnCys: 0.346 ± 0.141
2.074GlnAsp: 2.074 ± 0.391
3.629GlnGlu: 3.629 ± 0.465
1.555GlnPhe: 1.555 ± 0.272
2.247GlnGly: 2.247 ± 0.453
0.518GlnHis: 0.518 ± 0.339
3.37GlnIle: 3.37 ± 0.579
3.889GlnLys: 3.889 ± 0.558
3.802GlnLeu: 3.802 ± 0.571
0.691GlnMet: 0.691 ± 0.304
2.16GlnAsn: 2.16 ± 0.421
0.951GlnPro: 0.951 ± 0.306
1.555GlnGln: 1.555 ± 0.392
1.988GlnArg: 1.988 ± 0.431
2.42GlnSer: 2.42 ± 0.493
3.629GlnThr: 3.629 ± 0.594
2.247GlnVal: 2.247 ± 0.456
0.259GlnTrp: 0.259 ± 0.146
1.21GlnTyr: 1.21 ± 0.29
0.0GlnXaa: 0.0 ± 0.0
Arg
2.592ArgAla: 2.592 ± 0.418
0.173ArgCys: 0.173 ± 0.125
2.506ArgAsp: 2.506 ± 0.537
3.37ArgGlu: 3.37 ± 0.658
1.988ArgPhe: 1.988 ± 0.438
2.938ArgGly: 2.938 ± 0.417
1.037ArgHis: 1.037 ± 0.211
3.975ArgIle: 3.975 ± 0.479
3.543ArgLys: 3.543 ± 0.797
4.234ArgLeu: 4.234 ± 0.489
1.037ArgMet: 1.037 ± 0.355
2.679ArgAsn: 2.679 ± 0.505
1.469ArgPro: 1.469 ± 0.424
2.16ArgGln: 2.16 ± 0.381
2.679ArgArg: 2.679 ± 0.543
1.728ArgSer: 1.728 ± 0.353
2.679ArgThr: 2.679 ± 0.63
2.333ArgVal: 2.333 ± 0.373
0.432ArgTrp: 0.432 ± 0.173
2.938ArgTyr: 2.938 ± 0.43
0.0ArgXaa: 0.0 ± 0.0
Ser
4.58SerAla: 4.58 ± 0.704
0.0SerCys: 0.0 ± 0.0
3.889SerAsp: 3.889 ± 0.666
4.753SerGlu: 4.753 ± 0.536
1.988SerPhe: 1.988 ± 0.354
4.321SerGly: 4.321 ± 0.757
0.951SerHis: 0.951 ± 0.285
3.543SerIle: 3.543 ± 0.598
3.543SerLys: 3.543 ± 0.525
5.099SerLeu: 5.099 ± 0.758
1.901SerMet: 1.901 ± 0.364
3.889SerAsn: 3.889 ± 0.872
1.642SerPro: 1.642 ± 0.292
2.16SerGln: 2.16 ± 0.612
3.111SerArg: 3.111 ± 0.546
4.062SerSer: 4.062 ± 0.715
3.284SerThr: 3.284 ± 0.802
4.839SerVal: 4.839 ± 0.538
0.259SerTrp: 0.259 ± 0.128
2.679SerTyr: 2.679 ± 0.542
0.0SerXaa: 0.0 ± 0.0
Thr
6.827ThrAla: 6.827 ± 1.746
0.0ThrCys: 0.0 ± 0.0
3.629ThrAsp: 3.629 ± 0.512
3.37ThrGlu: 3.37 ± 0.595
2.506ThrPhe: 2.506 ± 0.405
4.494ThrGly: 4.494 ± 0.782
0.518ThrHis: 0.518 ± 0.218
4.234ThrIle: 4.234 ± 0.747
4.321ThrLys: 4.321 ± 0.468
5.703ThrLeu: 5.703 ± 0.675
0.778ThrMet: 0.778 ± 0.26
2.765ThrAsn: 2.765 ± 0.629
1.728ThrPro: 1.728 ± 0.351
2.506ThrGln: 2.506 ± 0.627
1.988ThrArg: 1.988 ± 0.512
4.148ThrSer: 4.148 ± 0.66
4.234ThrThr: 4.234 ± 1.012
6.568ThrVal: 6.568 ± 1.231
0.864ThrTrp: 0.864 ± 0.254
2.42ThrTyr: 2.42 ± 0.444
0.0ThrXaa: 0.0 ± 0.0
Val
4.58ValAla: 4.58 ± 0.691
0.259ValCys: 0.259 ± 0.112
5.358ValAsp: 5.358 ± 0.579
5.963ValGlu: 5.963 ± 0.691
2.506ValPhe: 2.506 ± 0.494
3.197ValGly: 3.197 ± 0.424
0.605ValHis: 0.605 ± 0.226
3.197ValIle: 3.197 ± 0.461
5.185ValLys: 5.185 ± 0.545
5.012ValLeu: 5.012 ± 0.622
2.333ValMet: 2.333 ± 0.581
3.457ValAsn: 3.457 ± 0.435
1.469ValPro: 1.469 ± 0.453
3.025ValGln: 3.025 ± 0.601
3.37ValArg: 3.37 ± 0.575
5.531ValSer: 5.531 ± 1.004
4.062ValThr: 4.062 ± 0.695
5.185ValVal: 5.185 ± 0.868
1.555ValTrp: 1.555 ± 0.424
2.42ValTyr: 2.42 ± 0.402
0.0ValXaa: 0.0 ± 0.0
Trp
0.778TrpAla: 0.778 ± 0.249
0.086TrpCys: 0.086 ± 0.089
1.21TrpAsp: 1.21 ± 0.336
1.642TrpGlu: 1.642 ± 0.665
0.346TrpPhe: 0.346 ± 0.174
1.21TrpGly: 1.21 ± 0.347
0.173TrpHis: 0.173 ± 0.117
0.518TrpIle: 0.518 ± 0.175
0.951TrpLys: 0.951 ± 0.331
1.21TrpLeu: 1.21 ± 0.39
0.259TrpMet: 0.259 ± 0.129
1.037TrpAsn: 1.037 ± 0.555
0.086TrpPro: 0.086 ± 0.074
0.864TrpGln: 0.864 ± 0.253
0.346TrpArg: 0.346 ± 0.141
0.518TrpSer: 0.518 ± 0.272
0.951TrpThr: 0.951 ± 0.209
0.432TrpVal: 0.432 ± 0.158
0.259TrpTrp: 0.259 ± 0.116
0.518TrpTyr: 0.518 ± 0.196
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.679TyrAla: 2.679 ± 0.395
0.086TyrCys: 0.086 ± 0.099
3.025TyrAsp: 3.025 ± 0.671
2.247TyrGlu: 2.247 ± 0.508
1.383TyrPhe: 1.383 ± 0.342
2.42TyrGly: 2.42 ± 0.417
0.605TyrHis: 0.605 ± 0.225
3.025TyrIle: 3.025 ± 0.547
3.111TyrLys: 3.111 ± 0.692
3.197TyrLeu: 3.197 ± 0.475
1.037TyrMet: 1.037 ± 0.238
2.333TyrAsn: 2.333 ± 0.398
1.555TyrPro: 1.555 ± 0.422
1.901TyrGln: 1.901 ± 0.36
2.679TyrArg: 2.679 ± 0.508
1.642TyrSer: 1.642 ± 0.467
2.765TyrThr: 2.765 ± 0.461
1.469TyrVal: 1.469 ± 0.292
0.346TyrTrp: 0.346 ± 0.165
1.383TyrTyr: 1.383 ± 0.326
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 56 proteins (11573 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski