Amino acid dipepetide frequency for Synchytrium endobioticum

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	8.663AlaAla: 8.663 ± 0.079	1.112AlaCys: 1.112 ± 0.017	4.41AlaAsp: 4.41 ± 0.04	4.57AlaGlu: 4.57 ± 0.048	2.805AlaPhe: 2.805 ± 0.028	4.751AlaGly: 4.751 ± 0.04	1.97AlaHis: 1.97 ± 0.023	4.297AlaIle: 4.297 ± 0.035	4.27AlaLys: 4.27 ± 0.042	7.85AlaLeu: 7.85 ± 0.058	1.999AlaMet: 1.999 ± 0.025	3.111AlaAsn: 3.111 ± 0.034	4.516AlaPro: 4.516 ± 0.042	3.157AlaGln: 3.157 ± 0.033	4.861AlaArg: 4.861 ± 0.048	8.043AlaSer: 8.043 ± 0.061	5.574AlaThr: 5.574 ± 0.039	5.432AlaVal: 5.432 ± 0.045	0.851AlaTrp: 0.851 ± 0.015	2.152AlaTyr: 2.152 ± 0.028	0.003AlaXaa: 0.003 ± 0.001
Cys	0.943CysAla: 0.943 ± 0.018	0.328CysCys: 0.328 ± 0.01	0.724CysAsp: 0.724 ± 0.016	0.657CysGlu: 0.657 ± 0.013	0.558CysPhe: 0.558 ± 0.014	0.949CysGly: 0.949 ± 0.018	0.422CysHis: 0.422 ± 0.01	0.905CysIle: 0.905 ± 0.016	0.644CysLys: 0.644 ± 0.014	1.417CysLeu: 1.417 ± 0.022	0.337CysMet: 0.337 ± 0.01	0.552CysAsn: 0.552 ± 0.012	0.688CysPro: 0.688 ± 0.016	0.514CysGln: 0.514 ± 0.014	0.935CysArg: 0.935 ± 0.016	1.023CysSer: 1.023 ± 0.016	0.842CysThr: 0.842 ± 0.015	0.908CysVal: 0.908 ± 0.017	0.193CysTrp: 0.193 ± 0.008	0.387CysTyr: 0.387 ± 0.011	0.0CysXaa: 0.0 ± 0.0
Asp	5.14AspAla: 5.14 ± 0.039	0.693AspCys: 0.693 ± 0.014	4.94AspAsp: 4.94 ± 0.055	4.35AspGlu: 4.35 ± 0.042	2.004AspPhe: 2.004 ± 0.025	3.808AspGly: 3.808 ± 0.036	1.433AspHis: 1.433 ± 0.021	3.09AspIle: 3.09 ± 0.03	2.552AspLys: 2.552 ± 0.029	5.057AspLeu: 5.057 ± 0.045	1.4AspMet: 1.4 ± 0.021	1.981AspAsn: 1.981 ± 0.024	2.804AspPro: 2.804 ± 0.031	1.85AspGln: 1.85 ± 0.021	3.024AspArg: 3.024 ± 0.036	4.104AspSer: 4.104 ± 0.036	3.164AspThr: 3.164 ± 0.032	4.187AspVal: 4.187 ± 0.034	0.71AspTrp: 0.71 ± 0.014	1.641AspTyr: 1.641 ± 0.021	0.002AspXaa: 0.002 ± 0.001
Glu	4.906GluAla: 4.906 ± 0.048	0.76GluCys: 0.76 ± 0.015	3.401GluAsp: 3.401 ± 0.039	4.234GluGlu: 4.234 ± 0.051	1.987GluPhe: 1.987 ± 0.022	2.82GluGly: 2.82 ± 0.032	1.336GluHis: 1.336 ± 0.02	2.991GluIle: 2.991 ± 0.029	3.266GluLys: 3.266 ± 0.041	5.553GluLeu: 5.553 ± 0.051	1.481GluMet: 1.481 ± 0.02	2.192GluAsn: 2.192 ± 0.027	2.211GluPro: 2.211 ± 0.024	2.154GluGln: 2.154 ± 0.025	3.827GluArg: 3.827 ± 0.042	4.26GluSer: 4.26 ± 0.037	3.1GluThr: 3.1 ± 0.034	3.362GluVal: 3.362 ± 0.03	0.776GluTrp: 0.776 ± 0.015	1.818GluTyr: 1.818 ± 0.028	0.001GluXaa: 0.001 ± 0.001
Phe	2.758PheAla: 2.758 ± 0.035	0.525PheCys: 0.525 ± 0.012	2.207PheAsp: 2.207 ± 0.023	2.021PheGlu: 2.021 ± 0.027	1.269PhePhe: 1.269 ± 0.019	2.382PheGly: 2.382 ± 0.036	0.903PheHis: 0.903 ± 0.015	1.797PheIle: 1.797 ± 0.024	1.72PheLys: 1.72 ± 0.022	3.156PheLeu: 3.156 ± 0.033	0.863PheMet: 0.863 ± 0.017	1.297PheAsn: 1.297 ± 0.021	1.555PhePro: 1.555 ± 0.021	1.305PheGln: 1.305 ± 0.021	1.767PheArg: 1.767 ± 0.023	2.5PheSer: 2.5 ± 0.025	1.95PheThr: 1.95 ± 0.027	2.415PheVal: 2.415 ± 0.025	0.424PheTrp: 0.424 ± 0.011	1.006PheTyr: 1.006 ± 0.017	0.001PheXaa: 0.001 ± 0.0
Gly	4.453GlyAla: 4.453 ± 0.047	0.899GlyCys: 0.899 ± 0.018	3.226GlyAsp: 3.226 ± 0.033	2.626GlyGlu: 2.626 ± 0.03	2.099GlyPhe: 2.099 ± 0.025	4.495GlyGly: 4.495 ± 0.053	1.61GlyHis: 1.61 ± 0.022	3.158GlyIle: 3.158 ± 0.034	2.876GlyLys: 2.876 ± 0.034	5.075GlyLeu: 5.075 ± 0.038	1.441GlyMet: 1.441 ± 0.022	2.411GlyAsn: 2.411 ± 0.025	2.648GlyPro: 2.648 ± 0.028	1.955GlyGln: 1.955 ± 0.023	3.571GlyArg: 3.571 ± 0.034	4.989GlySer: 4.989 ± 0.048	3.479GlyThr: 3.479 ± 0.035	3.871GlyVal: 3.871 ± 0.04	0.777GlyTrp: 0.777 ± 0.017	1.706GlyTyr: 1.706 ± 0.029	0.003GlyXaa: 0.003 ± 0.001
His	2.14HisAla: 2.14 ± 0.027	0.394HisCys: 0.394 ± 0.012	1.641HisAsp: 1.641 ± 0.024	1.388HisGlu: 1.388 ± 0.021	0.915HisPhe: 0.915 ± 0.017	1.639HisGly: 1.639 ± 0.023	1.258HisHis: 1.258 ± 0.025	1.476HisIle: 1.476 ± 0.023	1.079HisLys: 1.079 ± 0.02	2.582HisLeu: 2.582 ± 0.03	0.542HisMet: 0.542 ± 0.013	0.991HisAsn: 0.991 ± 0.02	1.824HisPro: 1.824 ± 0.025	1.322HisGln: 1.322 ± 0.021	1.656HisArg: 1.656 ± 0.022	2.075HisSer: 2.075 ± 0.028	1.458HisThr: 1.458 ± 0.021	1.819HisVal: 1.819 ± 0.024	0.302HisTrp: 0.302 ± 0.009	0.794HisTyr: 0.794 ± 0.016	0.001HisXaa: 0.001 ± 0.0
Ile	4.338IleAla: 4.338 ± 0.033	0.844IleCys: 0.844 ± 0.016	2.99IleAsp: 2.99 ± 0.028	2.867IleGlu: 2.867 ± 0.029	1.756IlePhe: 1.756 ± 0.024	2.769IleGly: 2.769 ± 0.031	1.507IleHis: 1.507 ± 0.022	2.713IleIle: 2.713 ± 0.026	2.771IleLys: 2.771 ± 0.03	4.864IleLeu: 4.864 ± 0.044	1.222IleMet: 1.222 ± 0.018	2.055IleAsn: 2.055 ± 0.022	3.293IlePro: 3.293 ± 0.032	2.249IleGln: 2.249 ± 0.028	3.172IleArg: 3.172 ± 0.033	4.084IleSer: 4.084 ± 0.038	2.992IleThr: 2.992 ± 0.031	3.579IleVal: 3.579 ± 0.033	0.582IleTrp: 0.582 ± 0.013	1.404IleTyr: 1.404 ± 0.019	0.001IleXaa: 0.001 ± 0.0
Lys	4.213LysAla: 4.213 ± 0.046	0.699LysCys: 0.699 ± 0.015	2.773LysAsp: 2.773 ± 0.033	3.21LysGlu: 3.21 ± 0.037	1.562LysPhe: 1.562 ± 0.023	2.557LysGly: 2.557 ± 0.033	1.373LysHis: 1.373 ± 0.02	2.521LysIle: 2.521 ± 0.03	3.513LysLys: 3.513 ± 0.048	4.767LysLeu: 4.767 ± 0.04	1.26LysMet: 1.26 ± 0.02	1.979LysAsn: 1.979 ± 0.025	2.682LysPro: 2.682 ± 0.031	2.139LysGln: 2.139 ± 0.027	3.72LysArg: 3.72 ± 0.039	4.195LysSer: 4.195 ± 0.037	3.004LysThr: 3.004 ± 0.03	3.06LysVal: 3.06 ± 0.028	0.656LysTrp: 0.656 ± 0.012	1.642LysTyr: 1.642 ± 0.024	0.002LysXaa: 0.002 ± 0.001
Leu	7.973LeuAla: 7.973 ± 0.06	1.357LeuCys: 1.357 ± 0.022	5.373LeuAsp: 5.373 ± 0.037	5.654LeuGlu: 5.654 ± 0.058	3.17LeuPhe: 3.17 ± 0.033	4.912LeuGly: 4.912 ± 0.043	2.515LeuHis: 2.515 ± 0.029	4.235LeuIle: 4.235 ± 0.041	5.01LeuLys: 5.01 ± 0.048	8.811LeuLeu: 8.811 ± 0.073	2.06LeuMet: 2.06 ± 0.024	3.492LeuAsn: 3.492 ± 0.037	5.568LeuPro: 5.568 ± 0.046	4.158LeuGln: 4.158 ± 0.039	5.55LeuArg: 5.55 ± 0.044	7.7LeuSer: 7.7 ± 0.05	4.85LeuThr: 4.85 ± 0.037	5.935LeuVal: 5.935 ± 0.048	0.968LeuTrp: 0.968 ± 0.018	2.62LeuTyr: 2.62 ± 0.027	0.003LeuXaa: 0.003 ± 0.001
Met	2.137MetAla: 2.137 ± 0.022	0.29MetCys: 0.29 ± 0.009	1.471MetAsp: 1.471 ± 0.02	1.438MetGlu: 1.438 ± 0.02	0.706MetPhe: 0.706 ± 0.013	1.324MetGly: 1.324 ± 0.019	0.609MetHis: 0.609 ± 0.013	1.148MetIle: 1.148 ± 0.018	1.378MetLys: 1.378 ± 0.021	2.183MetLeu: 2.183 ± 0.027	0.721MetMet: 0.721 ± 0.016	1.06MetAsn: 1.06 ± 0.017	1.294MetPro: 1.294 ± 0.019	0.909MetGln: 0.909 ± 0.018	1.263MetArg: 1.263 ± 0.019	2.128MetSer: 2.128 ± 0.023	1.434MetThr: 1.434 ± 0.022	1.466MetVal: 1.466 ± 0.022	0.243MetTrp: 0.243 ± 0.007	0.647MetTyr: 0.647 ± 0.013	0.0MetXaa: 0.0 ± 0.0
Asn	3.454AsnAla: 3.454 ± 0.036	0.504AsnCys: 0.504 ± 0.011	2.429AsnAsp: 2.429 ± 0.026	2.242AsnGlu: 2.242 ± 0.028	1.219AsnPhe: 1.219 ± 0.018	2.81AsnGly: 2.81 ± 0.03	1.122AsnHis: 1.122 ± 0.019	2.238AsnIle: 2.238 ± 0.025	1.777AsnLys: 1.777 ± 0.023	3.416AsnLeu: 3.416 ± 0.03	0.996AsnMet: 0.996 ± 0.015	1.918AsnAsn: 1.918 ± 0.028	2.436AsnPro: 2.436 ± 0.026	1.619AsnGln: 1.619 ± 0.021	2.119AsnArg: 2.119 ± 0.025	3.129AsnSer: 3.129 ± 0.031	2.494AsnThr: 2.494 ± 0.027	2.793AsnVal: 2.793 ± 0.029	0.44AsnTrp: 0.44 ± 0.012	1.031AsnTyr: 1.031 ± 0.017	0.0AsnXaa: 0.0 ± 0.0
Pro	4.736ProAla: 4.736 ± 0.046	0.652ProCys: 0.652 ± 0.014	3.075ProAsp: 3.075 ± 0.03	2.803ProGlu: 2.803 ± 0.032	1.902ProPhe: 1.902 ± 0.025	2.808ProGly: 2.808 ± 0.03	1.563ProHis: 1.563 ± 0.025	2.734ProIle: 2.734 ± 0.029	2.438ProLys: 2.438 ± 0.027	4.747ProLeu: 4.747 ± 0.039	1.138ProMet: 1.138 ± 0.019	2.258ProAsn: 2.258 ± 0.024	5.535ProPro: 5.535 ± 0.068	2.196ProGln: 2.196 ± 0.03	3.044ProArg: 3.044 ± 0.035	6.526ProSer: 6.526 ± 0.052	4.074ProThr: 4.074 ± 0.042	3.469ProVal: 3.469 ± 0.038	0.518ProTrp: 0.518 ± 0.013	1.524ProTyr: 1.524 ± 0.024	0.001ProXaa: 0.001 ± 0.001
Gln	3.191GlnAla: 3.191 ± 0.033	0.502GlnCys: 0.502 ± 0.011	2.022GlnAsp: 2.022 ± 0.025	2.245GlnGlu: 2.245 ± 0.029	1.236GlnPhe: 1.236 ± 0.02	1.871GlnGly: 1.871 ± 0.023	1.277GlnHis: 1.277 ± 0.02	1.984GlnIle: 1.984 ± 0.024	1.948GlnLys: 1.948 ± 0.026	3.814GlnLeu: 3.814 ± 0.042	0.929GlnMet: 0.929 ± 0.017	1.507GlnAsn: 1.507 ± 0.02	2.493GlnPro: 2.493 ± 0.033	2.606GlnGln: 2.606 ± 0.041	2.529GlnArg: 2.529 ± 0.026	3.166GlnSer: 3.166 ± 0.033	2.223GlnThr: 2.223 ± 0.025	2.458GlnVal: 2.458 ± 0.026	0.469GlnTrp: 0.469 ± 0.012	1.243GlnTyr: 1.243 ± 0.023	0.003GlnXaa: 0.003 ± 0.001
Arg	4.561ArgAla: 4.561 ± 0.037	0.789ArgCys: 0.789 ± 0.016	3.422ArgAsp: 3.422 ± 0.036	3.349ArgGlu: 3.349 ± 0.036	1.998ArgPhe: 1.998 ± 0.024	3.178ArgGly: 3.178 ± 0.032	1.831ArgHis: 1.831 ± 0.023	3.332ArgIle: 3.332 ± 0.032	3.699ArgLys: 3.699 ± 0.033	5.69ArgLeu: 5.69 ± 0.044	1.503ArgMet: 1.503 ± 0.017	2.557ArgAsn: 2.557 ± 0.028	3.287ArgPro: 3.287 ± 0.033	2.567ArgGln: 2.567 ± 0.03	4.762ArgArg: 4.762 ± 0.047	4.474ArgSer: 4.474 ± 0.045	3.203ArgThr: 3.203 ± 0.03	3.617ArgVal: 3.617 ± 0.028	0.689ArgTrp: 0.689 ± 0.014	1.688ArgTyr: 1.688 ± 0.021	0.001ArgXaa: 0.001 ± 0.001
Ser	7.017SerAla: 7.017 ± 0.053	1.09SerCys: 1.09 ± 0.018	4.344SerAsp: 4.344 ± 0.038	3.896SerGlu: 3.896 ± 0.037	2.76SerPhe: 2.76 ± 0.031	4.831SerGly: 4.831 ± 0.037	2.259SerHis: 2.259 ± 0.029	4.557SerIle: 4.557 ± 0.037	4.276SerLys: 4.276 ± 0.034	7.608SerLeu: 7.608 ± 0.051	1.953SerMet: 1.953 ± 0.024	3.953SerAsn: 3.953 ± 0.036	5.559SerPro: 5.559 ± 0.055	3.18SerGln: 3.18 ± 0.031	5.17SerArg: 5.17 ± 0.045	10.444SerSer: 10.444 ± 0.09	6.309SerThr: 6.309 ± 0.052	4.854SerVal: 4.854 ± 0.04	0.902SerTrp: 0.902 ± 0.016	2.083SerTyr: 2.083 ± 0.025	0.002SerXaa: 0.002 ± 0.001
Thr	5.178ThrAla: 5.178 ± 0.04	0.866ThrCys: 0.866 ± 0.017	2.995ThrAsp: 2.995 ± 0.028	2.799ThrGlu: 2.799 ± 0.029	2.04ThrPhe: 2.04 ± 0.027	3.434ThrGly: 3.434 ± 0.035	1.523ThrHis: 1.523 ± 0.022	3.33ThrIle: 3.33 ± 0.036	2.826ThrLys: 2.826 ± 0.028	5.449ThrLeu: 5.449 ± 0.037	1.412ThrMet: 1.412 ± 0.02	2.497ThrAsn: 2.497 ± 0.029	4.154ThrPro: 4.154 ± 0.05	2.025ThrGln: 2.025 ± 0.024	3.466ThrArg: 3.466 ± 0.031	6.226ThrSer: 6.226 ± 0.05	4.598ThrThr: 4.598 ± 0.044	3.743ThrVal: 3.743 ± 0.037	0.653ThrTrp: 0.653 ± 0.014	1.59ThrTyr: 1.59 ± 0.019	0.002ThrXaa: 0.002 ± 0.001
Val	5.696ValAla: 5.696 ± 0.042	0.932ValCys: 0.932 ± 0.016	4.012ValAsp: 4.012 ± 0.036	3.777ValGlu: 3.777 ± 0.035	2.37ValPhe: 2.37 ± 0.029	3.661ValGly: 3.661 ± 0.036	1.587ValHis: 1.587 ± 0.022	3.305ValIle: 3.305 ± 0.03	3.4ValLys: 3.4 ± 0.033	6.11ValLeu: 6.11 ± 0.043	1.538ValMet: 1.538 ± 0.021	2.566ValAsn: 2.566 ± 0.024	3.455ValPro: 3.455 ± 0.033	2.26ValGln: 2.26 ± 0.027	3.361ValArg: 3.361 ± 0.028	5.047ValSer: 5.047 ± 0.038	3.705ValThr: 3.705 ± 0.038	4.712ValVal: 4.712 ± 0.043	0.743ValTrp: 0.743 ± 0.014	1.849ValTyr: 1.849 ± 0.024	0.002ValXaa: 0.002 ± 0.001
Trp	0.781TrpAla: 0.781 ± 0.015	0.207TrpCys: 0.207 ± 0.007	0.73TrpAsp: 0.73 ± 0.018	0.641TrpGlu: 0.641 ± 0.014	0.427TrpPhe: 0.427 ± 0.011	0.525TrpGly: 0.525 ± 0.013	0.306TrpHis: 0.306 ± 0.009	0.675TrpIle: 0.675 ± 0.015	0.74TrpLys: 0.74 ± 0.015	1.051TrpLeu: 1.051 ± 0.019	0.351TrpMet: 0.351 ± 0.011	0.579TrpAsn: 0.579 ± 0.012	0.454TrpPro: 0.454 ± 0.011	0.417TrpGln: 0.417 ± 0.012	0.738TrpArg: 0.738 ± 0.014	0.886TrpSer: 0.886 ± 0.015	0.745TrpThr: 0.745 ± 0.015	0.637TrpVal: 0.637 ± 0.015	0.188TrpTrp: 0.188 ± 0.008	0.363TrpTyr: 0.363 ± 0.01	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.116TyrAla: 2.116 ± 0.028	0.484TyrCys: 0.484 ± 0.012	1.747TyrAsp: 1.747 ± 0.023	1.665TyrGlu: 1.665 ± 0.024	1.037TyrPhe: 1.037 ± 0.019	1.842TyrGly: 1.842 ± 0.024	0.889TyrHis: 0.889 ± 0.017	1.562TyrIle: 1.562 ± 0.022	1.342TyrLys: 1.342 ± 0.021	2.715TyrLeu: 2.715 ± 0.031	0.702TyrMet: 0.702 ± 0.014	1.228TyrAsn: 1.228 ± 0.019	1.282TyrPro: 1.282 ± 0.02	1.134TyrGln: 1.134 ± 0.017	1.663TyrArg: 1.663 ± 0.021	2.05TyrSer: 2.05 ± 0.024	1.606TyrThr: 1.606 ± 0.024	1.768TyrVal: 1.768 ± 0.022	0.355TyrTrp: 0.355 ± 0.011	0.982TyrTyr: 0.982 ± 0.018	0.001TyrXaa: 0.001 ± 0.001
Xaa	0.005XaaAla: 0.005 ± 0.001	0.001XaaCys: 0.001 ± 0.0	0.001XaaAsp: 0.001 ± 0.001	0.001XaaGlu: 0.001 ± 0.0	0.001XaaPhe: 0.001 ± 0.0	0.002XaaGly: 0.002 ± 0.001	0.002XaaHis: 0.002 ± 0.001	0.001XaaIle: 0.001 ± 0.001	0.001XaaLys: 0.001 ± 0.0	0.001XaaLeu: 0.001 ± 0.001	0.001XaaMet: 0.001 ± 0.001	0.001XaaAsn: 0.001 ± 0.0	0.002XaaPro: 0.002 ± 0.001	0.001XaaGln: 0.001 ± 0.0	0.001XaaArg: 0.001 ± 0.001	0.003XaaSer: 0.003 ± 0.001	0.003XaaThr: 0.003 ± 0.001	0.002XaaVal: 0.002 ± 0.001	0.0XaaTrp: 0.0 ± 0.0	0.001XaaTyr: 0.001 ± 0.0	0.056XaaXaa: 0.056 ± 0.007

Statistics based on 7895 proteins (3746747 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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