Amino acid dipepetide frequency for Ectothiorhodospira magna

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	11.947AlaAla: 11.947 ± 0.158	1.207AlaCys: 1.207 ± 0.047	5.686AlaAsp: 5.686 ± 0.086	6.091AlaGlu: 6.091 ± 0.097	3.365AlaPhe: 3.365 ± 0.062	8.861AlaGly: 8.861 ± 0.122	2.589AlaHis: 2.589 ± 0.058	4.949AlaIle: 4.949 ± 0.094	2.312AlaLys: 2.312 ± 0.066	13.507AlaLeu: 13.507 ± 0.168	3.101AlaMet: 3.101 ± 0.074	2.313AlaAsn: 2.313 ± 0.063	4.612AlaPro: 4.612 ± 0.08	4.605AlaGln: 4.605 ± 0.084	8.827AlaArg: 8.827 ± 0.118	4.597AlaSer: 4.597 ± 0.082	4.809AlaThr: 4.809 ± 0.085	7.656AlaVal: 7.656 ± 0.112	1.434AlaTrp: 1.434 ± 0.044	2.126AlaTyr: 2.126 ± 0.057	0.0AlaXaa: 0.0 ± 0.0
Cys	0.829CysAla: 0.829 ± 0.036	0.12CysCys: 0.12 ± 0.013	0.521CysAsp: 0.521 ± 0.026	0.499CysGlu: 0.499 ± 0.029	0.325CysPhe: 0.325 ± 0.021	0.922CysGly: 0.922 ± 0.038	0.416CysHis: 0.416 ± 0.026	0.448CysIle: 0.448 ± 0.024	0.22CysLys: 0.22 ± 0.018	1.172CysLeu: 1.172 ± 0.037	0.194CysMet: 0.194 ± 0.016	0.254CysAsn: 0.254 ± 0.02	0.602CysPro: 0.602 ± 0.031	0.457CysGln: 0.457 ± 0.031	0.877CysArg: 0.877 ± 0.032	0.448CysSer: 0.448 ± 0.024	0.451CysThr: 0.451 ± 0.025	0.599CysVal: 0.599 ± 0.028	0.143CysTrp: 0.143 ± 0.015	0.199CysTyr: 0.199 ± 0.016	0.0CysXaa: 0.0 ± 0.0
Asp	5.701AspAla: 5.701 ± 0.092	0.507AspCys: 0.507 ± 0.026	3.395AspAsp: 3.395 ± 0.071	3.565AspGlu: 3.565 ± 0.065	2.146AspPhe: 2.146 ± 0.052	4.669AspGly: 4.669 ± 0.078	1.702AspHis: 1.702 ± 0.048	3.107AspIle: 3.107 ± 0.071	1.465AspLys: 1.465 ± 0.052	6.453AspLeu: 6.453 ± 0.097	1.535AspMet: 1.535 ± 0.041	1.532AspAsn: 1.532 ± 0.038	3.673AspPro: 3.673 ± 0.071	2.57AspGln: 2.57 ± 0.062	4.605AspArg: 4.605 ± 0.087	2.43AspSer: 2.43 ± 0.058	3.273AspThr: 3.273 ± 0.063	3.695AspVal: 3.695 ± 0.066	0.968AspTrp: 0.968 ± 0.04	1.656AspTyr: 1.656 ± 0.044	0.0AspXaa: 0.0 ± 0.0
Glu	7.439GluAla: 7.439 ± 0.103	0.431GluCys: 0.431 ± 0.023	3.429GluAsp: 3.429 ± 0.07	3.381GluGlu: 3.381 ± 0.091	1.744GluPhe: 1.744 ± 0.042	4.486GluGly: 4.486 ± 0.077	1.57GluHis: 1.57 ± 0.045	3.166GluIle: 3.166 ± 0.062	1.852GluLys: 1.852 ± 0.059	5.893GluLeu: 5.893 ± 0.096	1.503GluMet: 1.503 ± 0.044	1.462GluAsn: 1.462 ± 0.048	2.654GluPro: 2.654 ± 0.094	3.552GluGln: 3.552 ± 0.069	5.272GluArg: 5.272 ± 0.096	2.9GluSer: 2.9 ± 0.056	3.182GluThr: 3.182 ± 0.06	4.179GluVal: 4.179 ± 0.063	0.672GluTrp: 0.672 ± 0.028	1.311GluTyr: 1.311 ± 0.038	0.0GluXaa: 0.0 ± 0.0
Phe	3.159PheAla: 3.159 ± 0.059	0.39PheCys: 0.39 ± 0.021	2.226PheAsp: 2.226 ± 0.057	2.088PheGlu: 2.088 ± 0.052	1.355PhePhe: 1.355 ± 0.044	2.81PheGly: 2.81 ± 0.067	0.905PheHis: 0.905 ± 0.032	1.733PheIle: 1.733 ± 0.054	0.995PheLys: 0.995 ± 0.04	3.404PheLeu: 3.404 ± 0.077	0.918PheMet: 0.918 ± 0.03	1.135PheAsn: 1.135 ± 0.041	1.506PhePro: 1.506 ± 0.045	1.37PheGln: 1.37 ± 0.041	2.239PheArg: 2.239 ± 0.055	2.02PheSer: 2.02 ± 0.055	1.993PheThr: 1.993 ± 0.053	2.232PheVal: 2.232 ± 0.054	0.496PheTrp: 0.496 ± 0.027	0.872PheTyr: 0.872 ± 0.032	0.0PheXaa: 0.0 ± 0.0
Gly	7.06GlyAla: 7.06 ± 0.115	0.937GlyCys: 0.937 ± 0.04	4.496GlyAsp: 4.496 ± 0.077	4.983GlyGlu: 4.983 ± 0.079	3.107GlyPhe: 3.107 ± 0.066	6.212GlyGly: 6.212 ± 0.104	2.343GlyHis: 2.343 ± 0.052	4.595GlyIle: 4.595 ± 0.085	2.645GlyLys: 2.645 ± 0.061	9.204GlyLeu: 9.204 ± 0.13	2.465GlyMet: 2.465 ± 0.054	2.066GlyAsn: 2.066 ± 0.061	2.988GlyPro: 2.988 ± 0.058	3.517GlyGln: 3.517 ± 0.076	6.238GlyArg: 6.238 ± 0.089	3.839GlySer: 3.839 ± 0.073	4.2GlyThr: 4.2 ± 0.084	6.206GlyVal: 6.206 ± 0.105	1.213GlyTrp: 1.213 ± 0.037	2.253GlyTyr: 2.253 ± 0.057	0.0GlyXaa: 0.0 ± 0.0
His	2.44HisAla: 2.44 ± 0.056	0.345HisCys: 0.345 ± 0.021	1.532HisAsp: 1.532 ± 0.045	1.356HisGlu: 1.356 ± 0.041	1.054HisPhe: 1.054 ± 0.037	2.37HisGly: 2.37 ± 0.052	0.992HisHis: 0.992 ± 0.044	1.222HisIle: 1.222 ± 0.041	0.611HisLys: 0.611 ± 0.029	3.196HisLeu: 3.196 ± 0.075	0.587HisMet: 0.587 ± 0.025	0.592HisAsn: 0.592 ± 0.03	1.963HisPro: 1.963 ± 0.06	1.227HisGln: 1.227 ± 0.037	2.137HisArg: 2.137 ± 0.055	1.063HisSer: 1.063 ± 0.038	1.261HisThr: 1.261 ± 0.042	1.725HisVal: 1.725 ± 0.047	0.517HisTrp: 0.517 ± 0.024	0.839HisTyr: 0.839 ± 0.032	0.0HisXaa: 0.0 ± 0.0
Ile	4.865IleAla: 4.865 ± 0.085	0.499IleCys: 0.499 ± 0.025	2.888IleAsp: 2.888 ± 0.066	3.057IleGlu: 3.057 ± 0.068	1.517IlePhe: 1.517 ± 0.04	3.894IleGly: 3.894 ± 0.073	1.505IleHis: 1.505 ± 0.047	2.528IleIle: 2.528 ± 0.065	1.563IleLys: 1.563 ± 0.052	5.201IleLeu: 5.201 ± 0.092	1.106IleMet: 1.106 ± 0.034	1.799IleAsn: 1.799 ± 0.057	2.692IlePro: 2.692 ± 0.061	2.244IleGln: 2.244 ± 0.056	4.034IleArg: 4.034 ± 0.073	2.752IleSer: 2.752 ± 0.062	3.057IleThr: 3.057 ± 0.069	2.982IleVal: 2.982 ± 0.069	0.498IleTrp: 0.498 ± 0.026	1.161IleTyr: 1.161 ± 0.039	0.0IleXaa: 0.0 ± 0.0
Lys	3.359LysAla: 3.359 ± 0.088	0.161LysCys: 0.161 ± 0.016	1.644LysAsp: 1.644 ± 0.051	1.464LysGlu: 1.464 ± 0.05	0.655LysPhe: 0.655 ± 0.032	2.244LysGly: 2.244 ± 0.059	0.684LysHis: 0.684 ± 0.028	1.297LysIle: 1.297 ± 0.041	1.094LysLys: 1.094 ± 0.05	2.438LysLeu: 2.438 ± 0.07	0.599LysMet: 0.599 ± 0.029	0.802LysAsn: 0.802 ± 0.033	1.538LysPro: 1.538 ± 0.046	1.09LysGln: 1.09 ± 0.038	1.987LysArg: 1.987 ± 0.053	1.416LysSer: 1.416 ± 0.046	1.724LysThr: 1.724 ± 0.044	2.084LysVal: 2.084 ± 0.066	0.232LysTrp: 0.232 ± 0.017	0.536LysTyr: 0.536 ± 0.023	0.0LysXaa: 0.0 ± 0.0
Leu	12.753LeuAla: 12.753 ± 0.161	1.035LeuCys: 1.035 ± 0.037	7.009LeuAsp: 7.009 ± 0.093	7.57LeuGlu: 7.57 ± 0.107	3.775LeuPhe: 3.775 ± 0.089	8.694LeuGly: 8.694 ± 0.118	2.58LeuHis: 2.58 ± 0.061	5.457LeuIle: 5.457 ± 0.087	3.482LeuLys: 3.482 ± 0.07	12.046LeuLeu: 12.046 ± 0.189	3.06LeuMet: 3.06 ± 0.061	3.163LeuAsn: 3.163 ± 0.063	6.262LeuPro: 6.262 ± 0.086	4.202LeuGln: 4.202 ± 0.077	8.062LeuArg: 8.062 ± 0.115	6.438LeuSer: 6.438 ± 0.097	5.951LeuThr: 5.951 ± 0.096	8.065LeuVal: 8.065 ± 0.125	1.296LeuTrp: 1.296 ± 0.046	2.31LeuTyr: 2.31 ± 0.054	0.0LeuXaa: 0.0 ± 0.0
Met	3.393MetAla: 3.393 ± 0.062	0.146MetCys: 0.146 ± 0.013	1.712MetAsp: 1.712 ± 0.045	1.51MetGlu: 1.51 ± 0.043	0.611MetPhe: 0.611 ± 0.03	2.266MetGly: 2.266 ± 0.055	0.516MetHis: 0.516 ± 0.025	1.268MetIle: 1.268 ± 0.042	0.873MetLys: 0.873 ± 0.032	2.576MetLeu: 2.576 ± 0.06	0.685MetMet: 0.685 ± 0.034	0.868MetAsn: 0.868 ± 0.03	1.579MetPro: 1.579 ± 0.042	1.005MetGln: 1.005 ± 0.041	1.544MetArg: 1.544 ± 0.041	1.53MetSer: 1.53 ± 0.042	1.749MetThr: 1.749 ± 0.054	1.97MetVal: 1.97 ± 0.043	0.152MetTrp: 0.152 ± 0.013	0.371MetTyr: 0.371 ± 0.024	0.0MetXaa: 0.0 ± 0.0
Asn	2.627AsnAla: 2.627 ± 0.068	0.223AsnCys: 0.223 ± 0.017	1.402AsnAsp: 1.402 ± 0.046	1.26AsnGlu: 1.26 ± 0.039	0.878AsnPhe: 0.878 ± 0.042	1.95AsnGly: 1.95 ± 0.045	0.667AsnHis: 0.667 ± 0.029	1.485AsnIle: 1.485 ± 0.049	0.674AsnLys: 0.674 ± 0.032	3.022AsnLeu: 3.022 ± 0.06	0.676AsnMet: 0.676 ± 0.032	0.702AsnAsn: 0.702 ± 0.035	1.933AsnPro: 1.933 ± 0.055	1.189AsnGln: 1.189 ± 0.045	2.105AsnArg: 2.105 ± 0.059	1.003AsnSer: 1.003 ± 0.039	1.532AsnThr: 1.532 ± 0.052	1.729AsnVal: 1.729 ± 0.054	0.331AsnTrp: 0.331 ± 0.022	0.592AsnTyr: 0.592 ± 0.027	0.0AsnXaa: 0.0 ± 0.0
Pro	5.571ProAla: 5.571 ± 0.107	0.46ProCys: 0.46 ± 0.025	3.856ProAsp: 3.856 ± 0.073	4.194ProGlu: 4.194 ± 0.095	1.78ProPhe: 1.78 ± 0.045	4.649ProGly: 4.649 ± 0.087	1.309ProHis: 1.309 ± 0.042	2.069ProIle: 2.069 ± 0.055	1.216ProLys: 1.216 ± 0.041	5.444ProLeu: 5.444 ± 0.095	1.407ProMet: 1.407 ± 0.035	1.127ProAsn: 1.127 ± 0.037	3.006ProPro: 3.006 ± 0.079	1.901ProGln: 1.901 ± 0.051	3.379ProArg: 3.379 ± 0.075	2.271ProSer: 2.271 ± 0.054	2.233ProThr: 2.233 ± 0.062	4.638ProVal: 4.638 ± 0.084	0.83ProTrp: 0.83 ± 0.034	1.045ProTyr: 1.045 ± 0.036	0.0ProXaa: 0.0 ± 0.0
Gln	5.937GlnAla: 5.937 ± 0.11	0.383GlnCys: 0.383 ± 0.021	2.336GlnAsp: 2.336 ± 0.061	2.347GlnGlu: 2.347 ± 0.06	1.138GlnPhe: 1.138 ± 0.037	3.946GlnGly: 3.946 ± 0.071	1.047GlnHis: 1.047 ± 0.038	2.017GlnIle: 2.017 ± 0.058	0.983GlnLys: 0.983 ± 0.035	3.967GlnLeu: 3.967 ± 0.08	1.022GlnMet: 1.022 ± 0.037	0.825GlnAsn: 0.825 ± 0.031	2.086GlnPro: 2.086 ± 0.058	2.173GlnGln: 2.173 ± 0.062	3.492GlnArg: 3.492 ± 0.074	1.98GlnSer: 1.98 ± 0.051	2.173GlnThr: 2.173 ± 0.051	4.01GlnVal: 4.01 ± 0.069	0.687GlnTrp: 0.687 ± 0.035	0.783GlnTyr: 0.783 ± 0.035	0.0GlnXaa: 0.0 ± 0.0
Arg	6.738ArgAla: 6.738 ± 0.086	0.719ArgCys: 0.719 ± 0.029	4.572ArgAsp: 4.572 ± 0.074	5.146ArgGlu: 5.146 ± 0.104	3.13ArgPhe: 3.13 ± 0.067	4.983ArgGly: 4.983 ± 0.073	2.551ArgHis: 2.551 ± 0.061	4.392ArgIle: 4.392 ± 0.082	2.053ArgLys: 2.053 ± 0.065	9.707ArgLeu: 9.707 ± 0.123	2.121ArgMet: 2.121 ± 0.046	1.855ArgAsn: 1.855 ± 0.047	3.68ArgPro: 3.68 ± 0.068	3.894ArgGln: 3.894 ± 0.088	6.577ArgArg: 6.577 ± 0.104	3.261ArgSer: 3.261 ± 0.059	3.499ArgThr: 3.499 ± 0.067	5.556ArgVal: 5.556 ± 0.087	1.1ArgTrp: 1.1 ± 0.037	2.108ArgTyr: 2.108 ± 0.049	0.0ArgXaa: 0.0 ± 0.0
Ser	4.764SerAla: 4.764 ± 0.091	0.445SerCys: 0.445 ± 0.025	2.499SerAsp: 2.499 ± 0.05	2.624SerGlu: 2.624 ± 0.056	1.635SerPhe: 1.635 ± 0.046	4.711SerGly: 4.711 ± 0.081	1.353SerHis: 1.353 ± 0.04	2.268SerIle: 2.268 ± 0.064	1.162SerLys: 1.162 ± 0.038	5.746SerLeu: 5.746 ± 0.087	1.239SerMet: 1.239 ± 0.04	1.227SerAsn: 1.227 ± 0.044	2.817SerPro: 2.817 ± 0.061	1.848SerGln: 1.848 ± 0.053	4.173SerArg: 4.173 ± 0.08	2.653SerSer: 2.653 ± 0.071	2.433SerThr: 2.433 ± 0.062	3.382SerVal: 3.382 ± 0.063	0.611SerTrp: 0.611 ± 0.027	1.019SerTyr: 1.019 ± 0.035	0.0SerXaa: 0.0 ± 0.0
Thr	5.231ThrAla: 5.231 ± 0.081	0.55ThrCys: 0.55 ± 0.031	2.906ThrAsp: 2.906 ± 0.062	2.749ThrGlu: 2.749 ± 0.054	1.669ThrPhe: 1.669 ± 0.05	4.911ThrGly: 4.911 ± 0.088	1.454ThrHis: 1.454 ± 0.047	2.149ThrIle: 2.149 ± 0.059	0.905ThrLys: 0.905 ± 0.038	7.549ThrLeu: 7.549 ± 0.117	0.942ThrMet: 0.942 ± 0.039	1.048ThrAsn: 1.048 ± 0.042	3.498ThrPro: 3.498 ± 0.068	2.178ThrGln: 2.178 ± 0.05	3.778ThrArg: 3.778 ± 0.07	2.265ThrSer: 2.265 ± 0.06	2.61ThrThr: 2.61 ± 0.058	3.96ThrVal: 3.96 ± 0.069	0.658ThrTrp: 0.658 ± 0.03	1.093ThrTyr: 1.093 ± 0.037	0.0ThrXaa: 0.0 ± 0.0
Val	7.726ValAla: 7.726 ± 0.11	0.739ValCys: 0.739 ± 0.032	4.629ValAsp: 4.629 ± 0.077	4.371ValGlu: 4.371 ± 0.072	2.517ValPhe: 2.517 ± 0.058	5.23ValGly: 5.23 ± 0.092	1.76ValHis: 1.76 ± 0.05	4.194ValIle: 4.194 ± 0.066	2.053ValLys: 2.053 ± 0.054	7.89ValLeu: 7.89 ± 0.116	2.307ValMet: 2.307 ± 0.05	2.287ValAsn: 2.287 ± 0.06	3.452ValPro: 3.452 ± 0.069	2.468ValGln: 2.468 ± 0.064	5.077ValArg: 5.077 ± 0.083	4.026ValSer: 4.026 ± 0.072	4.214ValThr: 4.214 ± 0.073	5.967ValVal: 5.967 ± 0.116	0.725ValTrp: 0.725 ± 0.035	1.523ValTyr: 1.523 ± 0.039	0.0ValXaa: 0.0 ± 0.0
Trp	1.022TrpAla: 1.022 ± 0.037	0.141TrpCys: 0.141 ± 0.013	0.623TrpAsp: 0.623 ± 0.026	0.672TrpGlu: 0.672 ± 0.031	0.55TrpPhe: 0.55 ± 0.027	0.825TrpGly: 0.825 ± 0.034	0.399TrpHis: 0.399 ± 0.024	0.651TrpIle: 0.651 ± 0.033	0.353TrpLys: 0.353 ± 0.018	1.96TrpLeu: 1.96 ± 0.065	0.373TrpMet: 0.373 ± 0.02	0.337TrpAsn: 0.337 ± 0.019	0.649TrpPro: 0.649 ± 0.03	0.731TrpGln: 0.731 ± 0.033	1.067TrpArg: 1.067 ± 0.042	0.679TrpSer: 0.679 ± 0.025	0.548TrpThr: 0.548 ± 0.023	1.004TrpVal: 1.004 ± 0.033	0.234TrpTrp: 0.234 ± 0.018	0.351TrpTyr: 0.351 ± 0.024	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.03TyrAla: 2.03 ± 0.054	0.254TyrCys: 0.254 ± 0.016	1.286TyrAsp: 1.286 ± 0.039	1.152TyrGlu: 1.152 ± 0.042	0.895TyrPhe: 0.895 ± 0.033	1.934TyrGly: 1.934 ± 0.044	0.69TyrHis: 0.69 ± 0.027	0.848TyrIle: 0.848 ± 0.036	0.533TyrLys: 0.533 ± 0.024	2.836TyrLeu: 2.836 ± 0.068	0.482TyrMet: 0.482 ± 0.023	0.585TyrAsn: 0.585 ± 0.03	1.197TyrPro: 1.197 ± 0.036	1.111TyrGln: 1.111 ± 0.041	2.173TyrArg: 2.173 ± 0.054	1.041TyrSer: 1.041 ± 0.035	1.213TyrThr: 1.213 ± 0.038	1.516TyrVal: 1.516 ± 0.043	0.372TyrTrp: 0.372 ± 0.024	0.591TyrTyr: 0.591 ± 0.029	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2463 proteins (827883 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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