Amino acid dipepetide frequency for Coccidioides posadasii (strain RMSCC 757 / Silveira) (Valley fever fungus)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	7.857AlaAla: 7.857 ± 0.061	1.058AlaCys: 1.058 ± 0.018	3.797AlaAsp: 3.797 ± 0.031	4.914AlaGlu: 4.914 ± 0.039	2.953AlaPhe: 2.953 ± 0.027	5.263AlaGly: 5.263 ± 0.042	1.724AlaHis: 1.724 ± 0.02	4.134AlaIle: 4.134 ± 0.036	4.11AlaLys: 4.11 ± 0.039	7.308AlaLeu: 7.308 ± 0.047	1.794AlaMet: 1.794 ± 0.024	2.849AlaAsn: 2.849 ± 0.027	4.444AlaPro: 4.444 ± 0.046	3.135AlaGln: 3.135 ± 0.033	5.021AlaArg: 5.021 ± 0.04	7.017AlaSer: 7.017 ± 0.044	4.805AlaThr: 4.805 ± 0.036	4.902AlaVal: 4.902 ± 0.035	1.005AlaTrp: 1.005 ± 0.018	1.908AlaTyr: 1.908 ± 0.022	0.0AlaXaa: 0.0 ± 0.0
Cys	0.948CysAla: 0.948 ± 0.018	0.311CysCys: 0.311 ± 0.01	0.677CysAsp: 0.677 ± 0.013	0.682CysGlu: 0.682 ± 0.014	0.584CysPhe: 0.584 ± 0.011	0.977CysGly: 0.977 ± 0.017	0.404CysHis: 0.404 ± 0.01	0.735CysIle: 0.735 ± 0.014	0.586CysLys: 0.586 ± 0.012	1.396CysLeu: 1.396 ± 0.022	0.297CysMet: 0.297 ± 0.009	0.453CysAsn: 0.453 ± 0.01	0.785CysPro: 0.785 ± 0.015	0.499CysGln: 0.499 ± 0.011	0.927CysArg: 0.927 ± 0.016	1.071CysSer: 1.071 ± 0.019	0.692CysThr: 0.692 ± 0.015	0.831CysVal: 0.831 ± 0.016	0.216CysTrp: 0.216 ± 0.009	0.375CysTyr: 0.375 ± 0.011	0.0CysXaa: 0.0 ± 0.0
Asp	4.154AspAla: 4.154 ± 0.032	0.661AspCys: 0.661 ± 0.014	3.947AspAsp: 3.947 ± 0.042	4.23AspGlu: 4.23 ± 0.043	2.125AspPhe: 2.125 ± 0.022	3.822AspGly: 3.822 ± 0.034	1.246AspHis: 1.246 ± 0.018	3.254AspIle: 3.254 ± 0.028	2.377AspLys: 2.377 ± 0.027	4.856AspLeu: 4.856 ± 0.041	1.213AspMet: 1.213 ± 0.017	1.887AspAsn: 1.887 ± 0.023	3.311AspPro: 3.311 ± 0.03	1.851AspGln: 1.851 ± 0.024	3.139AspArg: 3.139 ± 0.032	4.191AspSer: 4.191 ± 0.04	2.792AspThr: 2.792 ± 0.026	3.471AspVal: 3.471 ± 0.031	0.813AspTrp: 0.813 ± 0.016	1.492AspTyr: 1.492 ± 0.022	0.0AspXaa: 0.0 ± 0.0
Glu	5.073GluAla: 5.073 ± 0.045	0.682GluCys: 0.682 ± 0.014	4.055GluAsp: 4.055 ± 0.042	5.541GluGlu: 5.541 ± 0.062	2.056GluPhe: 2.056 ± 0.025	3.621GluGly: 3.621 ± 0.029	1.367GluHis: 1.367 ± 0.02	3.291GluIle: 3.291 ± 0.034	3.892GluLys: 3.892 ± 0.039	5.299GluLeu: 5.299 ± 0.039	1.484GluMet: 1.484 ± 0.017	2.565GluAsn: 2.565 ± 0.025	2.942GluPro: 2.942 ± 0.035	2.496GluGln: 2.496 ± 0.025	4.191GluArg: 4.191 ± 0.043	4.635GluSer: 4.635 ± 0.04	3.387GluThr: 3.387 ± 0.027	3.385GluVal: 3.385 ± 0.035	0.876GluTrp: 0.876 ± 0.015	1.69GluTyr: 1.69 ± 0.022	0.0GluXaa: 0.0 ± 0.0
Phe	2.853PheAla: 2.853 ± 0.026	0.647PheCys: 0.647 ± 0.012	2.195PheAsp: 2.195 ± 0.026	2.172PheGlu: 2.172 ± 0.025	1.596PhePhe: 1.596 ± 0.025	2.704PheGly: 2.704 ± 0.03	0.952PheHis: 0.952 ± 0.016	1.832PheIle: 1.832 ± 0.024	1.583PheLys: 1.583 ± 0.021	3.546PheLeu: 3.546 ± 0.033	0.754PheMet: 0.754 ± 0.015	1.418PheAsn: 1.418 ± 0.019	2.131PhePro: 2.131 ± 0.023	1.415PheGln: 1.415 ± 0.018	2.168PheArg: 2.168 ± 0.025	3.259PheSer: 3.259 ± 0.026	2.087PheThr: 2.087 ± 0.024	2.254PheVal: 2.254 ± 0.028	0.601PheTrp: 0.601 ± 0.013	1.093PheTyr: 1.093 ± 0.017	0.0PheXaa: 0.0 ± 0.0
Gly	4.789GlyAla: 4.789 ± 0.038	0.892GlyCys: 0.892 ± 0.018	3.495GlyAsp: 3.495 ± 0.037	3.689GlyGlu: 3.689 ± 0.035	2.648GlyPhe: 2.648 ± 0.031	5.348GlyGly: 5.348 ± 0.059	1.619GlyHis: 1.619 ± 0.025	3.527GlyIle: 3.527 ± 0.037	3.556GlyLys: 3.556 ± 0.028	5.769GlyLeu: 5.769 ± 0.043	1.547GlyMet: 1.547 ± 0.022	2.557GlyAsn: 2.557 ± 0.028	3.26GlyPro: 3.26 ± 0.032	2.46GlyGln: 2.46 ± 0.028	4.351GlyArg: 4.351 ± 0.037	5.613GlySer: 5.613 ± 0.043	3.675GlyThr: 3.675 ± 0.034	4.084GlyVal: 4.084 ± 0.043	1.117GlyTrp: 1.117 ± 0.019	2.026GlyTyr: 2.026 ± 0.024	0.0GlyXaa: 0.0 ± 0.0
His	1.833HisAla: 1.833 ± 0.021	0.386HisCys: 0.386 ± 0.011	1.248HisAsp: 1.248 ± 0.019	1.318HisGlu: 1.318 ± 0.018	0.963HisPhe: 0.963 ± 0.017	1.746HisGly: 1.746 ± 0.023	0.873HisHis: 0.873 ± 0.021	1.348HisIle: 1.348 ± 0.019	0.962HisLys: 0.962 ± 0.015	2.295HisLeu: 2.295 ± 0.022	0.501HisMet: 0.501 ± 0.012	0.882HisAsn: 0.882 ± 0.016	1.817HisPro: 1.817 ± 0.023	1.033HisGln: 1.033 ± 0.018	1.764HisArg: 1.764 ± 0.022	2.07HisSer: 2.07 ± 0.026	1.295HisThr: 1.295 ± 0.018	1.401HisVal: 1.401 ± 0.018	0.337HisTrp: 0.337 ± 0.008	0.651HisTyr: 0.651 ± 0.013	0.0HisXaa: 0.0 ± 0.0
Ile	3.985IleAla: 3.985 ± 0.03	0.829IleCys: 0.829 ± 0.014	2.913IleAsp: 2.913 ± 0.025	2.951IleGlu: 2.951 ± 0.029	2.097IlePhe: 2.097 ± 0.023	3.039IleGly: 3.039 ± 0.036	1.326IleHis: 1.326 ± 0.018	2.619IleIle: 2.619 ± 0.029	2.34IleLys: 2.34 ± 0.024	4.87IleLeu: 4.87 ± 0.041	1.033IleMet: 1.033 ± 0.016	1.854IleAsn: 1.854 ± 0.022	3.422IlePro: 3.422 ± 0.031	2.022IleGln: 2.022 ± 0.023	3.108IleArg: 3.108 ± 0.03	4.348IleSer: 4.348 ± 0.036	2.798IleThr: 2.798 ± 0.027	3.047IleVal: 3.047 ± 0.034	0.699IleTrp: 0.699 ± 0.014	1.431IleTyr: 1.431 ± 0.02	0.0IleXaa: 0.0 ± 0.0
Lys	4.219LysAla: 4.219 ± 0.039	0.59LysCys: 0.59 ± 0.013	2.819LysAsp: 2.819 ± 0.027	3.591LysGlu: 3.591 ± 0.042	1.606LysPhe: 1.606 ± 0.019	3.054LysGly: 3.054 ± 0.03	1.192LysHis: 1.192 ± 0.019	2.496LysIle: 2.496 ± 0.026	3.557LysLys: 3.557 ± 0.053	4.36LysLeu: 4.36 ± 0.034	1.076LysMet: 1.076 ± 0.016	1.842LysAsn: 1.842 ± 0.022	2.955LysPro: 2.955 ± 0.031	2.049LysGln: 2.049 ± 0.025	3.834LysArg: 3.834 ± 0.028	3.804LysSer: 3.804 ± 0.033	2.739LysThr: 2.739 ± 0.029	2.838LysVal: 2.838 ± 0.029	0.67LysTrp: 0.67 ± 0.013	1.461LysTyr: 1.461 ± 0.019	0.0LysXaa: 0.0 ± 0.0
Leu	7.317LeuAla: 7.317 ± 0.049	1.299LeuCys: 1.299 ± 0.02	5.118LeuAsp: 5.118 ± 0.04	5.672LeuGlu: 5.672 ± 0.051	3.393LeuPhe: 3.393 ± 0.032	5.737LeuGly: 5.737 ± 0.039	2.358LeuHis: 2.358 ± 0.025	4.033LeuIle: 4.033 ± 0.036	4.463LeuLys: 4.463 ± 0.038	8.471LeuLeu: 8.471 ± 0.065	1.774LeuMet: 1.774 ± 0.019	3.324LeuAsn: 3.324 ± 0.026	5.586LeuPro: 5.586 ± 0.037	3.922LeuGln: 3.922 ± 0.04	6.174LeuArg: 6.174 ± 0.049	7.825LeuSer: 7.825 ± 0.056	4.601LeuThr: 4.601 ± 0.04	5.174LeuVal: 5.174 ± 0.038	1.156LeuTrp: 1.156 ± 0.019	2.301LeuTyr: 2.301 ± 0.026	0.0LeuXaa: 0.0 ± 0.0
Met	2.158MetAla: 2.158 ± 0.025	0.263MetCys: 0.263 ± 0.008	1.227MetAsp: 1.227 ± 0.021	1.395MetGlu: 1.395 ± 0.02	0.723MetPhe: 0.723 ± 0.013	1.432MetGly: 1.432 ± 0.019	0.493MetHis: 0.493 ± 0.011	1.039MetIle: 1.039 ± 0.018	1.125MetLys: 1.125 ± 0.017	1.838MetLeu: 1.838 ± 0.021	0.546MetMet: 0.546 ± 0.01	0.8MetAsn: 0.8 ± 0.015	1.215MetPro: 1.215 ± 0.015	0.829MetGln: 0.829 ± 0.016	1.3MetArg: 1.3 ± 0.018	1.828MetSer: 1.828 ± 0.018	1.229MetThr: 1.229 ± 0.017	1.271MetVal: 1.271 ± 0.019	0.255MetTrp: 0.255 ± 0.008	0.513MetTyr: 0.513 ± 0.012	0.0MetXaa: 0.0 ± 0.0
Asn	3.013AsnAla: 3.013 ± 0.029	0.511AsnCys: 0.511 ± 0.012	1.93AsnAsp: 1.93 ± 0.021	2.106AsnGlu: 2.106 ± 0.027	1.394AsnPhe: 1.394 ± 0.02	2.879AsnGly: 2.879 ± 0.029	0.913AsnHis: 0.913 ± 0.015	2.195AsnIle: 2.195 ± 0.024	1.681AsnLys: 1.681 ± 0.023	3.345AsnLeu: 3.345 ± 0.031	0.848AsnMet: 0.848 ± 0.014	1.524AsnAsn: 1.524 ± 0.027	2.637AsnPro: 2.637 ± 0.026	1.419AsnGln: 1.419 ± 0.02	2.184AsnArg: 2.184 ± 0.026	2.919AsnSer: 2.919 ± 0.029	2.119AsnThr: 2.119 ± 0.023	2.314AsnVal: 2.314 ± 0.023	0.544AsnTrp: 0.544 ± 0.012	1.008AsnTyr: 1.008 ± 0.016	0.0AsnXaa: 0.0 ± 0.0
Pro	4.935ProAla: 4.935 ± 0.046	0.674ProCys: 0.674 ± 0.014	3.143ProAsp: 3.143 ± 0.028	3.96ProGlu: 3.96 ± 0.039	2.179ProPhe: 2.179 ± 0.026	4.037ProGly: 4.037 ± 0.036	1.458ProHis: 1.458 ± 0.019	2.706ProIle: 2.706 ± 0.025	2.888ProLys: 2.888 ± 0.031	4.956ProLeu: 4.956 ± 0.032	1.1ProMet: 1.1 ± 0.016	2.351ProAsn: 2.351 ± 0.025	5.7ProPro: 5.7 ± 0.077	2.577ProGln: 2.577 ± 0.029	3.745ProArg: 3.745 ± 0.035	6.511ProSer: 6.511 ± 0.059	3.981ProThr: 3.981 ± 0.035	3.586ProVal: 3.586 ± 0.036	0.733ProTrp: 0.733 ± 0.012	1.541ProTyr: 1.541 ± 0.022	0.0ProXaa: 0.0 ± 0.0
Gln	3.251GlnAla: 3.251 ± 0.03	0.493GlnCys: 0.493 ± 0.011	1.977GlnAsp: 1.977 ± 0.025	2.433GlnGlu: 2.433 ± 0.024	1.323GlnPhe: 1.323 ± 0.019	2.416GlnGly: 2.416 ± 0.026	1.118GlnHis: 1.118 ± 0.018	1.925GlnIle: 1.925 ± 0.019	2.155GlnLys: 2.155 ± 0.024	3.5GlnLeu: 3.5 ± 0.033	0.886GlnMet: 0.886 ± 0.016	1.688GlnAsn: 1.688 ± 0.02	2.727GlnPro: 2.727 ± 0.036	2.357GlnGln: 2.357 ± 0.042	2.854GlnArg: 2.854 ± 0.031	3.323GlnSer: 3.323 ± 0.031	2.223GlnThr: 2.223 ± 0.027	2.071GlnVal: 2.071 ± 0.022	0.493GlnTrp: 0.493 ± 0.01	1.108GlnTyr: 1.108 ± 0.018	0.0GlnXaa: 0.0 ± 0.0
Arg	4.83ArgAla: 4.83 ± 0.036	0.875ArgCys: 0.875 ± 0.016	3.5ArgAsp: 3.5 ± 0.034	4.207ArgGlu: 4.207 ± 0.039	2.292ArgPhe: 2.292 ± 0.026	3.964ArgGly: 3.964 ± 0.035	1.749ArgHis: 1.749 ± 0.024	3.217ArgIle: 3.217 ± 0.029	3.827ArgLys: 3.827 ± 0.032	5.811ArgLeu: 5.811 ± 0.04	1.43ArgMet: 1.43 ± 0.018	2.498ArgAsn: 2.498 ± 0.025	3.87ArgPro: 3.87 ± 0.038	2.774ArgGln: 2.774 ± 0.027	5.874ArgArg: 5.874 ± 0.052	5.492ArgSer: 5.492 ± 0.046	3.495ArgThr: 3.495 ± 0.028	3.535ArgVal: 3.535 ± 0.029	0.954ArgTrp: 0.954 ± 0.017	1.74ArgTyr: 1.74 ± 0.02	0.0ArgXaa: 0.0 ± 0.0
Ser	6.54SerAla: 6.54 ± 0.046	1.009SerCys: 1.009 ± 0.02	4.21SerAsp: 4.21 ± 0.039	4.443SerGlu: 4.443 ± 0.038	3.162SerPhe: 3.162 ± 0.028	5.596SerGly: 5.596 ± 0.038	2.18SerHis: 2.18 ± 0.025	4.217SerIle: 4.217 ± 0.032	4.117SerLys: 4.117 ± 0.035	7.724SerLeu: 7.724 ± 0.047	1.813SerMet: 1.813 ± 0.023	3.164SerAsn: 3.164 ± 0.031	6.039SerPro: 6.039 ± 0.065	3.588SerGln: 3.588 ± 0.035	5.803SerArg: 5.803 ± 0.044	9.401SerSer: 9.401 ± 0.076	5.656SerThr: 5.656 ± 0.046	4.577SerVal: 4.577 ± 0.033	1.075SerTrp: 1.075 ± 0.017	2.037SerTyr: 2.037 ± 0.023	0.0SerXaa: 0.0 ± 0.0
Thr	4.619ThrAla: 4.619 ± 0.039	0.759ThrCys: 0.759 ± 0.015	2.664ThrAsp: 2.664 ± 0.028	3.095ThrGlu: 3.095 ± 0.028	2.143ThrPhe: 2.143 ± 0.026	3.956ThrGly: 3.956 ± 0.036	1.304ThrHis: 1.304 ± 0.017	2.978ThrIle: 2.978 ± 0.027	2.683ThrLys: 2.683 ± 0.025	5.075ThrLeu: 5.075 ± 0.036	1.18ThrMet: 1.18 ± 0.016	2.024ThrAsn: 2.024 ± 0.024	4.266ThrPro: 4.266 ± 0.036	2.004ThrGln: 2.004 ± 0.022	3.3ThrArg: 3.3 ± 0.031	5.276ThrSer: 5.276 ± 0.041	3.779ThrThr: 3.779 ± 0.043	3.465ThrVal: 3.465 ± 0.032	0.779ThrTrp: 0.779 ± 0.014	1.459ThrTyr: 1.459 ± 0.02	0.0ThrXaa: 0.0 ± 0.0
Val	4.69ValAla: 4.69 ± 0.036	0.856ValCys: 0.856 ± 0.017	3.544ValAsp: 3.544 ± 0.026	3.814ValGlu: 3.814 ± 0.03	2.318ValPhe: 2.318 ± 0.025	3.69ValGly: 3.69 ± 0.039	1.373ValHis: 1.373 ± 0.019	2.932ValIle: 2.932 ± 0.031	2.924ValLys: 2.924 ± 0.033	5.348ValLeu: 5.348 ± 0.041	1.242ValMet: 1.242 ± 0.017	2.186ValAsn: 2.186 ± 0.021	3.54ValPro: 3.54 ± 0.033	2.28ValGln: 2.28 ± 0.021	3.5ValArg: 3.5 ± 0.031	4.692ValSer: 4.692 ± 0.035	3.227ValThr: 3.227 ± 0.033	3.913ValVal: 3.913 ± 0.037	0.788ValTrp: 0.788 ± 0.014	1.587ValTyr: 1.587 ± 0.02	0.0ValXaa: 0.0 ± 0.0
Trp	1.027TrpAla: 1.027 ± 0.017	0.209TrpCys: 0.209 ± 0.007	0.833TrpAsp: 0.833 ± 0.018	0.848TrpGlu: 0.848 ± 0.017	0.505TrpPhe: 0.505 ± 0.011	0.829TrpGly: 0.829 ± 0.015	0.335TrpHis: 0.335 ± 0.009	0.751TrpIle: 0.751 ± 0.014	0.804TrpLys: 0.804 ± 0.015	1.295TrpLeu: 1.295 ± 0.018	0.367TrpMet: 0.367 ± 0.01	0.617TrpAsn: 0.617 ± 0.013	0.612TrpPro: 0.612 ± 0.013	0.531TrpGln: 0.531 ± 0.011	1.001TrpArg: 1.001 ± 0.018	0.99TrpSer: 0.99 ± 0.019	0.788TrpThr: 0.788 ± 0.014	0.798TrpVal: 0.798 ± 0.015	0.257TrpTrp: 0.257 ± 0.008	0.372TrpTyr: 0.372 ± 0.01	0.0TrpXaa: 0.0 ± 0.0
Tyr	1.906TyrAla: 1.906 ± 0.024	0.446TyrCys: 0.446 ± 0.011	1.541TyrAsp: 1.541 ± 0.021	1.464TyrGlu: 1.464 ± 0.02	1.196TyrPhe: 1.196 ± 0.017	1.912TyrGly: 1.912 ± 0.026	0.742TyrHis: 0.742 ± 0.015	1.499TyrIle: 1.499 ± 0.016	1.122TyrLys: 1.122 ± 0.018	2.636TyrLeu: 2.636 ± 0.027	0.594TyrMet: 0.594 ± 0.011	0.999TyrAsn: 0.999 ± 0.016	1.504TyrPro: 1.504 ± 0.019	1.082TyrGln: 1.082 ± 0.016	1.695TyrArg: 1.695 ± 0.021	2.086TyrSer: 2.086 ± 0.027	1.439TyrThr: 1.439 ± 0.021	1.528TyrVal: 1.528 ± 0.021	0.402TyrTrp: 0.402 ± 0.011	0.863TyrTyr: 0.863 ± 0.016	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 10212 proteins (4174551 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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