Amino acid dipepetide frequency for Prevotella melaninogenica (strain ATCC 25845 / DSM 7089 / JCM 6325 / VPI 2381 / B282) (Bacteroides melaninogenicus)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
5.815AlaAla: 5.815 ± 0.131
0.853AlaCys: 0.853 ± 0.034
4.364AlaAsp: 4.364 ± 0.078
4.615AlaGlu: 4.615 ± 0.084
3.127AlaPhe: 3.127 ± 0.063
4.82AlaGly: 4.82 ± 0.1
1.334AlaHis: 1.334 ± 0.041
4.798AlaIle: 4.798 ± 0.076
4.82AlaLys: 4.82 ± 0.076
6.534AlaLeu: 6.534 ± 0.098
2.019AlaMet: 2.019 ± 0.056
3.527AlaAsn: 3.527 ± 0.07
2.226AlaPro: 2.226 ± 0.059
3.027AlaGln: 3.027 ± 0.074
2.932AlaArg: 2.932 ± 0.054
4.245AlaSer: 4.245 ± 0.082
4.032AlaThr: 4.032 ± 0.088
4.707AlaVal: 4.707 ± 0.076
0.814AlaTrp: 0.814 ± 0.032
3.073AlaTyr: 3.073 ± 0.065
0.0AlaXaa: 0.0 ± 0.0
Cys
0.742CysAla: 0.742 ± 0.028
0.18CysCys: 0.18 ± 0.015
0.61CysAsp: 0.61 ± 0.027
0.6CysGlu: 0.6 ± 0.031
0.495CysPhe: 0.495 ± 0.023
0.962CysGly: 0.962 ± 0.037
0.349CysHis: 0.349 ± 0.023
0.787CysIle: 0.787 ± 0.036
0.707CysLys: 0.707 ± 0.029
1.018CysLeu: 1.018 ± 0.035
0.282CysMet: 0.282 ± 0.016
0.6CysAsn: 0.6 ± 0.028
0.518CysPro: 0.518 ± 0.028
0.381CysGln: 0.381 ± 0.021
0.543CysArg: 0.543 ± 0.027
0.723CysSer: 0.723 ± 0.032
0.573CysThr: 0.573 ± 0.024
0.74CysVal: 0.74 ± 0.034
0.147CysTrp: 0.147 ± 0.015
0.49CysTyr: 0.49 ± 0.024
0.0CysXaa: 0.0 ± 0.0
Asp
4.183AspAla: 4.183 ± 0.067
0.648AspCys: 0.648 ± 0.03
3.108AspAsp: 3.108 ± 0.067
3.978AspGlu: 3.978 ± 0.082
3.061AspPhe: 3.061 ± 0.069
4.171AspGly: 4.171 ± 0.096
0.971AspHis: 0.971 ± 0.035
4.319AspIle: 4.319 ± 0.075
4.355AspLys: 4.355 ± 0.082
4.62AspLeu: 4.62 ± 0.083
1.539AspMet: 1.539 ± 0.045
3.223AspAsn: 3.223 ± 0.06
1.894AspPro: 1.894 ± 0.042
1.347AspGln: 1.347 ± 0.044
2.421AspArg: 2.421 ± 0.056
3.318AspSer: 3.318 ± 0.074
2.792AspThr: 2.792 ± 0.059
3.809AspVal: 3.809 ± 0.065
0.818AspTrp: 0.818 ± 0.027
3.025AspTyr: 3.025 ± 0.079
0.0AspXaa: 0.0 ± 0.0
Glu
4.674GluAla: 4.674 ± 0.082
0.613GluCys: 0.613 ± 0.031
3.409GluAsp: 3.409 ± 0.08
4.872GluGlu: 4.872 ± 0.111
2.246GluPhe: 2.246 ± 0.05
4.0GluGly: 4.0 ± 0.067
1.365GluHis: 1.365 ± 0.043
3.972GluIle: 3.972 ± 0.087
4.966GluLys: 4.966 ± 0.102
5.767GluLeu: 5.767 ± 0.087
1.872GluMet: 1.872 ± 0.049
3.303GluAsn: 3.303 ± 0.069
1.788GluPro: 1.788 ± 0.046
2.768GluGln: 2.768 ± 0.066
3.306GluArg: 3.306 ± 0.076
2.98GluSer: 2.98 ± 0.066
3.117GluThr: 3.117 ± 0.066
4.048GluVal: 4.048 ± 0.071
0.779GluTrp: 0.779 ± 0.036
2.513GluTyr: 2.513 ± 0.056
0.0GluXaa: 0.0 ± 0.0
Phe
3.099PheAla: 3.099 ± 0.066
0.637PheCys: 0.637 ± 0.03
2.834PheAsp: 2.834 ± 0.058
2.299PheGlu: 2.299 ± 0.045
2.184PhePhe: 2.184 ± 0.065
3.231PheGly: 3.231 ± 0.072
0.987PheHis: 0.987 ± 0.038
3.023PheIle: 3.023 ± 0.073
2.583PheLys: 2.583 ± 0.055
3.713PheLeu: 3.713 ± 0.088
1.217PheMet: 1.217 ± 0.039
2.442PheAsn: 2.442 ± 0.056
1.615PhePro: 1.615 ± 0.043
1.27PheGln: 1.27 ± 0.043
2.011PheArg: 2.011 ± 0.054
3.308PheSer: 3.308 ± 0.061
2.826PheThr: 2.826 ± 0.052
2.831PheVal: 2.831 ± 0.062
0.47PheTrp: 0.47 ± 0.026
1.902PheTyr: 1.902 ± 0.052
0.0PheXaa: 0.0 ± 0.0
Gly
4.417GlyAla: 4.417 ± 0.101
0.861GlyCys: 0.861 ± 0.038
3.573GlyAsp: 3.573 ± 0.076
3.883GlyGlu: 3.883 ± 0.076
3.053GlyPhe: 3.053 ± 0.061
4.749GlyGly: 4.749 ± 0.113
1.33GlyHis: 1.33 ± 0.038
4.814GlyIle: 4.814 ± 0.08
5.474GlyLys: 5.474 ± 0.103
5.783GlyLeu: 5.783 ± 0.085
1.972GlyMet: 1.972 ± 0.046
3.529GlyAsn: 3.529 ± 0.082
1.323GlyPro: 1.323 ± 0.044
2.281GlyGln: 2.281 ± 0.053
3.048GlyArg: 3.048 ± 0.064
4.008GlySer: 4.008 ± 0.093
4.027GlyThr: 4.027 ± 0.086
4.937GlyVal: 4.937 ± 0.094
0.933GlyTrp: 0.933 ± 0.04
3.315GlyTyr: 3.315 ± 0.08
0.0GlyXaa: 0.0 ± 0.0
His
1.227HisAla: 1.227 ± 0.038
0.32HisCys: 0.32 ± 0.022
1.068HisAsp: 1.068 ± 0.035
1.136HisGlu: 1.136 ± 0.039
1.048HisPhe: 1.048 ± 0.036
1.323HisGly: 1.323 ± 0.042
0.551HisHis: 0.551 ± 0.029
1.556HisIle: 1.556 ± 0.048
1.223HisLys: 1.223 ± 0.038
1.895HisLeu: 1.895 ± 0.046
0.347HisMet: 0.347 ± 0.021
1.015HisAsn: 1.015 ± 0.034
1.018HisPro: 1.018 ± 0.037
0.766HisGln: 0.766 ± 0.034
0.981HisArg: 0.981 ± 0.035
1.201HisSer: 1.201 ± 0.041
1.101HisThr: 1.101 ± 0.037
1.121HisVal: 1.121 ± 0.036
0.245HisTrp: 0.245 ± 0.018
0.977HisTyr: 0.977 ± 0.038
0.0HisXaa: 0.0 ± 0.0
Ile
5.243IleAla: 5.243 ± 0.09
0.872IleCys: 0.872 ± 0.036
4.539IleAsp: 4.539 ± 0.076
4.316IleGlu: 4.316 ± 0.066
2.722IlePhe: 2.722 ± 0.068
4.493IleGly: 4.493 ± 0.085
1.274IleHis: 1.274 ± 0.039
4.668IleIle: 4.668 ± 0.094
4.359IleLys: 4.359 ± 0.076
5.73IleLeu: 5.73 ± 0.109
1.497IleMet: 1.497 ± 0.045
3.591IleAsn: 3.591 ± 0.067
2.896IlePro: 2.896 ± 0.061
2.168IleGln: 2.168 ± 0.056
3.122IleArg: 3.122 ± 0.073
4.343IleSer: 4.343 ± 0.079
3.906IleThr: 3.906 ± 0.075
4.322IleVal: 4.322 ± 0.087
0.596IleTrp: 0.596 ± 0.028
2.568IleTyr: 2.568 ± 0.064
0.0IleXaa: 0.0 ± 0.0
Lys
5.474LysAla: 5.474 ± 0.086
0.519LysCys: 0.519 ± 0.025
4.393LysAsp: 4.393 ± 0.083
5.527LysGlu: 5.527 ± 0.102
2.399LysPhe: 2.399 ± 0.057
4.642LysGly: 4.642 ± 0.081
1.286LysHis: 1.286 ± 0.045
4.087LysIle: 4.087 ± 0.069
5.349LysLys: 5.349 ± 0.094
5.652LysLeu: 5.652 ± 0.095
2.208LysMet: 2.208 ± 0.062
3.589LysAsn: 3.589 ± 0.07
2.32LysPro: 2.32 ± 0.058
2.974LysGln: 2.974 ± 0.067
3.235LysArg: 3.235 ± 0.068
3.43LysSer: 3.43 ± 0.06
3.888LysThr: 3.888 ± 0.079
4.62LysVal: 4.62 ± 0.081
0.839LysTrp: 0.839 ± 0.032
2.94LysTyr: 2.94 ± 0.056
0.0LysXaa: 0.0 ± 0.0
Leu
6.264LeuAla: 6.264 ± 0.103
1.204LeuCys: 1.204 ± 0.046
4.742LeuAsp: 4.742 ± 0.083
4.601LeuGlu: 4.601 ± 0.082
4.104LeuPhe: 4.104 ± 0.083
5.752LeuGly: 5.752 ± 0.102
1.885LeuHis: 1.885 ± 0.055
5.349LeuIle: 5.349 ± 0.102
6.074LeuLys: 6.074 ± 0.094
8.439LeuLeu: 8.439 ± 0.149
2.487LeuMet: 2.487 ± 0.056
4.689LeuAsn: 4.689 ± 0.085
3.877LeuPro: 3.877 ± 0.066
3.412LeuGln: 3.412 ± 0.074
4.502LeuArg: 4.502 ± 0.077
6.859LeuSer: 6.859 ± 0.106
5.449LeuThr: 5.449 ± 0.084
5.219LeuVal: 5.219 ± 0.093
0.992LeuTrp: 0.992 ± 0.037
3.589LeuTyr: 3.589 ± 0.072
0.0LeuXaa: 0.0 ± 0.0
Met
2.215MetAla: 2.215 ± 0.051
0.219MetCys: 0.219 ± 0.016
1.458MetAsp: 1.458 ± 0.04
1.669MetGlu: 1.669 ± 0.05
0.981MetPhe: 0.981 ± 0.036
1.85MetGly: 1.85 ± 0.051
0.497MetHis: 0.497 ± 0.025
1.637MetIle: 1.637 ± 0.046
2.485MetLys: 2.485 ± 0.05
2.393MetLeu: 2.393 ± 0.05
0.872MetMet: 0.872 ± 0.037
1.491MetAsn: 1.491 ± 0.045
1.114MetPro: 1.114 ± 0.034
1.06MetGln: 1.06 ± 0.037
1.375MetArg: 1.375 ± 0.047
1.627MetSer: 1.627 ± 0.042
1.607MetThr: 1.607 ± 0.046
1.653MetVal: 1.653 ± 0.046
0.242MetTrp: 0.242 ± 0.017
0.809MetTyr: 0.809 ± 0.033
0.0MetXaa: 0.0 ± 0.0
Asn
3.667AsnAla: 3.667 ± 0.073
0.486AsnCys: 0.486 ± 0.024
2.957AsnAsp: 2.957 ± 0.066
2.982AsnGlu: 2.982 ± 0.066
2.346AsnPhe: 2.346 ± 0.052
4.02AsnGly: 4.02 ± 0.095
1.028AsnHis: 1.028 ± 0.035
3.923AsnIle: 3.923 ± 0.072
3.39AsnLys: 3.39 ± 0.062
4.432AsnLeu: 4.432 ± 0.079
1.24AsnMet: 1.24 ± 0.039
3.075AsnAsn: 3.075 ± 0.075
2.471AsnPro: 2.471 ± 0.061
1.831AsnGln: 1.831 ± 0.045
2.39AsnArg: 2.39 ± 0.061
3.022AsnSer: 3.022 ± 0.067
2.966AsnThr: 2.966 ± 0.066
3.374AsnVal: 3.374 ± 0.075
0.672AsnTrp: 0.672 ± 0.034
2.499AsnTyr: 2.499 ± 0.056
0.0AsnXaa: 0.0 ± 0.0
Pro
2.541ProAla: 2.541 ± 0.057
0.339ProCys: 0.339 ± 0.02
2.209ProAsp: 2.209 ± 0.048
2.714ProGlu: 2.714 ± 0.06
1.765ProPhe: 1.765 ± 0.045
2.014ProGly: 2.014 ± 0.056
0.721ProHis: 0.721 ± 0.031
2.367ProIle: 2.367 ± 0.059
2.357ProLys: 2.357 ± 0.06
3.127ProLeu: 3.127 ± 0.057
0.995ProMet: 0.995 ± 0.035
1.922ProAsn: 1.922 ± 0.056
0.673ProPro: 0.673 ± 0.033
1.473ProGln: 1.473 ± 0.043
1.33ProArg: 1.33 ± 0.044
2.37ProSer: 2.37 ± 0.057
2.312ProThr: 2.312 ± 0.05
2.623ProVal: 2.623 ± 0.057
0.447ProTrp: 0.447 ± 0.025
1.648ProTyr: 1.648 ± 0.052
0.0ProXaa: 0.0 ± 0.0
Gln
2.626GlnAla: 2.626 ± 0.059
0.308GlnCys: 0.308 ± 0.021
1.694GlnAsp: 1.694 ± 0.048
2.337GlnGlu: 2.337 ± 0.064
1.473GlnPhe: 1.473 ± 0.052
2.242GlnGly: 2.242 ± 0.056
0.825GlnHis: 0.825 ± 0.032
2.342GlnIle: 2.342 ± 0.058
2.635GlnLys: 2.635 ± 0.067
3.759GlnLeu: 3.759 ± 0.078
1.085GlnMet: 1.085 ± 0.039
1.835GlnAsn: 1.835 ± 0.048
1.385GlnPro: 1.385 ± 0.042
1.901GlnGln: 1.901 ± 0.058
1.952GlnArg: 1.952 ± 0.05
2.046GlnSer: 2.046 ± 0.052
2.112GlnThr: 2.112 ± 0.061
2.224GlnVal: 2.224 ± 0.052
0.494GlnTrp: 0.494 ± 0.026
1.627GlnTyr: 1.627 ± 0.044
0.0GlnXaa: 0.0 ± 0.0
Arg
2.717ArgAla: 2.717 ± 0.064
0.465ArgCys: 0.465 ± 0.023
2.277ArgAsp: 2.277 ± 0.052
2.996ArgGlu: 2.996 ± 0.082
2.187ArgPhe: 2.187 ± 0.051
2.624ArgGly: 2.624 ± 0.061
1.026ArgHis: 1.026 ± 0.032
3.339ArgIle: 3.339 ± 0.056
3.348ArgLys: 3.348 ± 0.07
4.505ArgLeu: 4.505 ± 0.077
1.502ArgMet: 1.502 ± 0.035
2.519ArgAsn: 2.519 ± 0.061
1.552ArgPro: 1.552 ± 0.049
2.049ArgGln: 2.049 ± 0.054
2.456ArgArg: 2.456 ± 0.06
2.485ArgSer: 2.485 ± 0.06
2.498ArgThr: 2.498 ± 0.056
2.698ArgVal: 2.698 ± 0.06
0.672ArgTrp: 0.672 ± 0.027
2.331ArgTyr: 2.331 ± 0.055
0.0ArgXaa: 0.0 ± 0.0
Ser
4.132SerAla: 4.132 ± 0.08
0.824SerCys: 0.824 ± 0.034
3.368SerAsp: 3.368 ± 0.062
3.376SerGlu: 3.376 ± 0.064
3.19SerPhe: 3.19 ± 0.062
3.911SerGly: 3.911 ± 0.087
1.291SerHis: 1.291 ± 0.035
4.214SerIle: 4.214 ± 0.067
3.814SerLys: 3.814 ± 0.076
6.108SerLeu: 6.108 ± 0.102
1.583SerMet: 1.583 ± 0.051
2.998SerAsn: 2.998 ± 0.071
2.206SerPro: 2.206 ± 0.052
2.093SerGln: 2.093 ± 0.05
2.636SerArg: 2.636 ± 0.051
3.965SerSer: 3.965 ± 0.077
3.41SerThr: 3.41 ± 0.068
4.331SerVal: 4.331 ± 0.093
0.831SerTrp: 0.831 ± 0.033
2.926SerTyr: 2.926 ± 0.065
0.0SerXaa: 0.0 ± 0.0
Thr
4.25ThrAla: 4.25 ± 0.089
0.56ThrCys: 0.56 ± 0.026
3.511ThrAsp: 3.511 ± 0.068
3.396ThrGlu: 3.396 ± 0.062
2.803ThrPhe: 2.803 ± 0.058
4.178ThrGly: 4.178 ± 0.083
1.051ThrHis: 1.051 ± 0.033
4.202ThrIle: 4.202 ± 0.071
3.287ThrLys: 3.287 ± 0.063
5.435ThrLeu: 5.435 ± 0.078
1.315ThrMet: 1.315 ± 0.04
2.72ThrAsn: 2.72 ± 0.064
2.657ThrPro: 2.657 ± 0.054
1.851ThrGln: 1.851 ± 0.049
2.186ThrArg: 2.186 ± 0.051
3.435ThrSer: 3.435 ± 0.065
3.665ThrThr: 3.665 ± 0.089
3.747ThrVal: 3.747 ± 0.069
0.685ThrTrp: 0.685 ± 0.03
2.518ThrTyr: 2.518 ± 0.068
0.0ThrXaa: 0.0 ± 0.0
Val
4.638ValAla: 4.638 ± 0.087
0.858ValCys: 0.858 ± 0.029
3.985ValAsp: 3.985 ± 0.079
3.937ValGlu: 3.937 ± 0.084
2.747ValPhe: 2.747 ± 0.062
4.391ValGly: 4.391 ± 0.089
1.059ValHis: 1.059 ± 0.038
4.353ValIle: 4.353 ± 0.086
4.492ValLys: 4.492 ± 0.074
5.596ValLeu: 5.596 ± 0.093
1.775ValMet: 1.775 ± 0.05
3.331ValAsn: 3.331 ± 0.066
2.426ValPro: 2.426 ± 0.054
2.037ValGln: 2.037 ± 0.05
3.013ValArg: 3.013 ± 0.062
4.45ValSer: 4.45 ± 0.077
3.852ValThr: 3.852 ± 0.088
4.538ValVal: 4.538 ± 0.081
0.717ValTrp: 0.717 ± 0.034
2.689ValTyr: 2.689 ± 0.061
0.0ValXaa: 0.0 ± 0.0
Trp
0.797TrpAla: 0.797 ± 0.033
0.151TrpCys: 0.151 ± 0.013
0.706TrpAsp: 0.706 ± 0.036
0.681TrpGlu: 0.681 ± 0.028
0.55TrpPhe: 0.55 ± 0.029
0.862TrpGly: 0.862 ± 0.037
0.282TrpHis: 0.282 ± 0.02
0.758TrpIle: 0.758 ± 0.03
0.911TrpLys: 0.911 ± 0.032
1.183TrpLeu: 1.183 ± 0.036
0.392TrpMet: 0.392 ± 0.022
0.758TrpAsn: 0.758 ± 0.028
0.227TrpPro: 0.227 ± 0.018
0.526TrpGln: 0.526 ± 0.025
0.586TrpArg: 0.586 ± 0.027
0.715TrpSer: 0.715 ± 0.03
0.687TrpThr: 0.687 ± 0.028
0.705TrpVal: 0.705 ± 0.033
0.188TrpTrp: 0.188 ± 0.017
0.465TrpTyr: 0.465 ± 0.02
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.961TyrAla: 2.961 ± 0.066
0.53TyrCys: 0.53 ± 0.028
2.794TyrAsp: 2.794 ± 0.073
2.444TyrGlu: 2.444 ± 0.054
2.001TyrPhe: 2.001 ± 0.051
3.074TyrGly: 3.074 ± 0.075
1.006TyrHis: 1.006 ± 0.039
2.718TyrIle: 2.718 ± 0.058
2.739TyrLys: 2.739 ± 0.065
3.804TyrLeu: 3.804 ± 0.073
1.052TyrMet: 1.052 ± 0.034
2.614TyrAsn: 2.614 ± 0.062
1.76TyrPro: 1.76 ± 0.051
1.689TyrGln: 1.689 ± 0.047
2.215TyrArg: 2.215 ± 0.06
2.678TyrSer: 2.678 ± 0.058
2.633TyrThr: 2.633 ± 0.062
2.636TyrVal: 2.636 ± 0.059
0.553TyrTrp: 0.553 ± 0.025
2.218TyrTyr: 2.218 ± 0.057
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2288 proteins (839578 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski