Amino acid dipepetide frequency for Monoraphidium neglectum

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	44.036AlaAla: 44.036 ± 0.276	2.207AlaCys: 2.207 ± 0.027	6.663AlaAsp: 6.663 ± 0.04	7.949AlaGlu: 7.949 ± 0.071	3.302AlaPhe: 3.302 ± 0.021	16.395AlaGly: 16.395 ± 0.082	2.526AlaHis: 2.526 ± 0.024	2.987AlaIle: 2.987 ± 0.024	3.812AlaLys: 3.812 ± 0.041	14.86AlaLeu: 14.86 ± 0.071	2.438AlaMet: 2.438 ± 0.021	2.389AlaAsn: 2.389 ± 0.023	11.15AlaPro: 11.15 ± 0.08	5.576AlaGln: 5.576 ± 0.049	10.358AlaArg: 10.358 ± 0.068	9.443AlaSer: 9.443 ± 0.046	6.225AlaThr: 6.225 ± 0.04	9.686AlaVal: 9.686 ± 0.045	1.889AlaTrp: 1.889 ± 0.02	1.961AlaTyr: 1.961 ± 0.02	0.0AlaXaa: 0.0 ± 0.0
Cys	1.918CysAla: 1.918 ± 0.022	0.434CysCys: 0.434 ± 0.01	0.738CysAsp: 0.738 ± 0.012	0.668CysGlu: 0.668 ± 0.013	0.443CysPhe: 0.443 ± 0.01	1.757CysGly: 1.757 ± 0.023	0.282CysHis: 0.282 ± 0.007	0.452CysIle: 0.452 ± 0.009	0.472CysLys: 0.472 ± 0.011	1.303CysLeu: 1.303 ± 0.018	0.314CysMet: 0.314 ± 0.007	0.363CysAsn: 0.363 ± 0.008	0.874CysPro: 0.874 ± 0.015	0.448CysGln: 0.448 ± 0.01	0.999CysArg: 0.999 ± 0.016	1.154CysSer: 1.154 ± 0.016	0.75CysThr: 0.75 ± 0.013	0.997CysVal: 0.997 ± 0.014	0.251CysTrp: 0.251 ± 0.006	0.29CysTyr: 0.29 ± 0.008	0.0CysXaa: 0.0 ± 0.0
Asp	7.806AspAla: 7.806 ± 0.053	0.691AspCys: 0.691 ± 0.012	3.172AspAsp: 3.172 ± 0.033	3.333AspGlu: 3.333 ± 0.033	1.296AspPhe: 1.296 ± 0.017	5.478AspGly: 5.478 ± 0.038	0.726AspHis: 0.726 ± 0.013	1.337AspIle: 1.337 ± 0.016	1.444AspLys: 1.444 ± 0.021	4.106AspLeu: 4.106 ± 0.029	0.856AspMet: 0.856 ± 0.013	0.914AspAsn: 0.914 ± 0.012	2.869AspPro: 2.869 ± 0.023	1.309AspGln: 1.309 ± 0.016	2.31AspArg: 2.31 ± 0.02	2.684AspSer: 2.684 ± 0.024	1.847AspThr: 1.847 ± 0.017	3.333AspVal: 3.333 ± 0.022	0.713AspTrp: 0.713 ± 0.013	0.924AspTyr: 0.924 ± 0.015	0.0AspXaa: 0.0 ± 0.0
Glu	8.984GluAla: 8.984 ± 0.076	0.604GluCys: 0.604 ± 0.01	2.907GluAsp: 2.907 ± 0.027	4.86GluGlu: 4.86 ± 0.063	1.216GluPhe: 1.216 ± 0.017	5.485GluGly: 5.485 ± 0.046	0.941GluHis: 0.941 ± 0.014	1.186GluIle: 1.186 ± 0.016	1.463GluLys: 1.463 ± 0.02	5.228GluLeu: 5.228 ± 0.037	0.954GluMet: 0.954 ± 0.012	0.691GluAsn: 0.691 ± 0.012	2.495GluPro: 2.495 ± 0.024	3.367GluGln: 3.367 ± 0.044	4.27GluArg: 4.27 ± 0.042	2.187GluSer: 2.187 ± 0.019	1.517GluThr: 1.517 ± 0.016	3.575GluVal: 3.575 ± 0.033	0.761GluTrp: 0.761 ± 0.011	0.833GluTyr: 0.833 ± 0.012	0.0GluXaa: 0.0 ± 0.0
Phe	2.856PheAla: 2.856 ± 0.023	0.474PheCys: 0.474 ± 0.01	1.609PheAsp: 1.609 ± 0.018	1.48PheGlu: 1.48 ± 0.018	0.879PhePhe: 0.879 ± 0.016	2.497PheGly: 2.497 ± 0.029	0.439PheHis: 0.439 ± 0.009	0.724PheIle: 0.724 ± 0.012	0.998PheLys: 0.998 ± 0.016	2.138PheLeu: 2.138 ± 0.022	0.546PheMet: 0.546 ± 0.01	0.776PheAsn: 0.776 ± 0.015	1.057PhePro: 1.057 ± 0.014	0.796PheGln: 0.796 ± 0.014	1.27PheArg: 1.27 ± 0.016	1.742PheSer: 1.742 ± 0.02	1.292PheThr: 1.292 ± 0.019	1.895PheVal: 1.895 ± 0.02	0.383PheTrp: 0.383 ± 0.009	0.567PheTyr: 0.567 ± 0.011	0.0PheXaa: 0.0 ± 0.0
Gly	17.318GlyAla: 17.318 ± 0.088	1.674GlyCys: 1.674 ± 0.019	5.162GlyAsp: 5.162 ± 0.037	4.603GlyGlu: 4.603 ± 0.036	2.337GlyPhe: 2.337 ± 0.026	20.022GlyGly: 20.022 ± 0.145	1.645GlyHis: 1.645 ± 0.018	2.031GlyIle: 2.031 ± 0.019	2.679GlyLys: 2.679 ± 0.028	7.594GlyLeu: 7.594 ± 0.045	1.69GlyMet: 1.69 ± 0.022	1.748GlyAsn: 1.748 ± 0.022	5.593GlyPro: 5.593 ± 0.037	3.22GlyGln: 3.22 ± 0.027	7.045GlyArg: 7.045 ± 0.05	7.949GlySer: 7.949 ± 0.053	3.801GlyThr: 3.801 ± 0.031	6.064GlyVal: 6.064 ± 0.038	1.387GlyTrp: 1.387 ± 0.016	1.565GlyTyr: 1.565 ± 0.021	0.0GlyXaa: 0.0 ± 0.0
His	2.625HisAla: 2.625 ± 0.026	0.321HisCys: 0.321 ± 0.007	0.837HisAsp: 0.837 ± 0.012	0.982HisGlu: 0.982 ± 0.014	0.517HisPhe: 0.517 ± 0.009	1.724HisGly: 1.724 ± 0.019	0.767HisHis: 0.767 ± 0.021	0.548HisIle: 0.548 ± 0.011	0.587HisLys: 0.587 ± 0.01	1.91HisLeu: 1.91 ± 0.019	0.436HisMet: 0.436 ± 0.007	0.443HisAsn: 0.443 ± 0.01	1.337HisPro: 1.337 ± 0.017	1.143HisGln: 1.143 ± 0.018	1.198HisArg: 1.198 ± 0.015	1.159HisSer: 1.159 ± 0.014	0.849HisThr: 0.849 ± 0.012	1.284HisVal: 1.284 ± 0.018	0.3HisTrp: 0.3 ± 0.007	0.428HisTyr: 0.428 ± 0.01	0.0HisXaa: 0.0 ± 0.0
Ile	2.888IleAla: 2.888 ± 0.026	0.401IleCys: 0.401 ± 0.009	1.394IleAsp: 1.394 ± 0.016	1.276IleGlu: 1.276 ± 0.015	0.707IlePhe: 0.707 ± 0.014	1.956IleGly: 1.956 ± 0.021	0.455IleHis: 0.455 ± 0.009	0.886IleIle: 0.886 ± 0.015	1.106IleLys: 1.106 ± 0.015	1.918IleLeu: 1.918 ± 0.019	0.536IleMet: 0.536 ± 0.01	0.817IleAsn: 0.817 ± 0.013	1.207IlePro: 1.207 ± 0.017	0.823IleGln: 0.823 ± 0.015	1.352IleArg: 1.352 ± 0.017	1.748IleSer: 1.748 ± 0.021	1.494IleThr: 1.494 ± 0.019	1.669IleVal: 1.669 ± 0.019	0.316IleTrp: 0.316 ± 0.007	0.516IleTyr: 0.516 ± 0.011	0.0IleXaa: 0.0 ± 0.0
Lys	4.139LysAla: 4.139 ± 0.04	0.353LysCys: 0.353 ± 0.009	1.377LysAsp: 1.377 ± 0.021	1.713LysGlu: 1.713 ± 0.025	0.705LysPhe: 0.705 ± 0.014	2.601LysGly: 2.601 ± 0.025	0.573LysHis: 0.573 ± 0.012	0.816LysIle: 0.816 ± 0.014	1.481LysLys: 1.481 ± 0.029	2.785LysLeu: 2.785 ± 0.029	0.564LysMet: 0.564 ± 0.01	0.604LysAsn: 0.604 ± 0.014	1.652LysPro: 1.652 ± 0.02	1.533LysGln: 1.533 ± 0.022	2.217LysArg: 2.217 ± 0.025	1.41LysSer: 1.41 ± 0.018	1.214LysThr: 1.214 ± 0.018	1.921LysVal: 1.921 ± 0.023	0.379LysTrp: 0.379 ± 0.009	0.61LysTyr: 0.61 ± 0.011	0.0LysXaa: 0.0 ± 0.0
Leu	13.571LeuAla: 13.571 ± 0.067	1.334LeuCys: 1.334 ± 0.016	4.486LeuAsp: 4.486 ± 0.034	5.394LeuGlu: 5.394 ± 0.043	2.307LeuPhe: 2.307 ± 0.025	7.559LeuGly: 7.559 ± 0.041	2.009LeuHis: 2.009 ± 0.018	2.067LeuIle: 2.067 ± 0.022	2.739LeuLys: 2.739 ± 0.026	11.918LeuLeu: 11.918 ± 0.105	1.856LeuMet: 1.856 ± 0.02	1.748LeuAsn: 1.748 ± 0.019	6.464LeuPro: 6.464 ± 0.048	5.255LeuGln: 5.255 ± 0.041	7.549LeuArg: 7.549 ± 0.052	5.982LeuSer: 5.982 ± 0.034	3.993LeuThr: 3.993 ± 0.034	6.045LeuVal: 6.045 ± 0.038	1.187LeuTrp: 1.187 ± 0.018	1.522LeuTyr: 1.522 ± 0.02	0.0LeuXaa: 0.0 ± 0.0
Met	2.71MetAla: 2.71 ± 0.023	0.257MetCys: 0.257 ± 0.007	0.842MetAsp: 0.842 ± 0.013	0.955MetGlu: 0.955 ± 0.013	0.451MetPhe: 0.451 ± 0.009	1.553MetGly: 1.553 ± 0.019	0.401MetHis: 0.401 ± 0.008	0.443MetIle: 0.443 ± 0.009	0.451MetLys: 0.451 ± 0.009	1.893MetLeu: 1.893 ± 0.019	0.489MetMet: 0.489 ± 0.012	0.311MetAsn: 0.311 ± 0.008	1.069MetPro: 1.069 ± 0.016	1.0MetGln: 1.0 ± 0.014	1.408MetArg: 1.408 ± 0.016	1.07MetSer: 1.07 ± 0.015	0.789MetThr: 0.789 ± 0.014	1.179MetVal: 1.179 ± 0.015	0.235MetTrp: 0.235 ± 0.006	0.346MetTyr: 0.346 ± 0.008	0.0MetXaa: 0.0 ± 0.0
Asn	2.398AsnAla: 2.398 ± 0.025	0.32AsnCys: 0.32 ± 0.008	0.795AsnAsp: 0.795 ± 0.012	0.848AsnGlu: 0.848 ± 0.014	0.646AsnPhe: 0.646 ± 0.012	2.072AsnGly: 2.072 ± 0.023	0.342AsnHis: 0.342 ± 0.007	0.744AsnIle: 0.744 ± 0.012	0.734AsnLys: 0.734 ± 0.013	1.723AsnLeu: 1.723 ± 0.022	0.402AsnMet: 0.402 ± 0.009	0.586AsnAsn: 0.586 ± 0.015	1.238AsnPro: 1.238 ± 0.017	0.624AsnGln: 0.624 ± 0.012	0.968AsnArg: 0.968 ± 0.015	1.265AsnSer: 1.265 ± 0.018	1.043AsnThr: 1.043 ± 0.017	1.333AsnVal: 1.333 ± 0.017	0.291AsnTrp: 0.291 ± 0.007	0.423AsnTyr: 0.423 ± 0.01	0.0AsnXaa: 0.0 ± 0.0
Pro	10.665ProAla: 10.665 ± 0.076	0.831ProCys: 0.831 ± 0.014	2.843ProAsp: 2.843 ± 0.023	3.192ProGlu: 3.192 ± 0.029	1.475ProPhe: 1.475 ± 0.016	6.524ProGly: 6.524 ± 0.041	1.298ProHis: 1.298 ± 0.017	1.225ProIle: 1.225 ± 0.014	1.682ProLys: 1.682 ± 0.022	5.738ProLeu: 5.738 ± 0.045	0.903ProMet: 0.903 ± 0.012	1.097ProAsn: 1.097 ± 0.013	6.846ProPro: 6.846 ± 0.065	3.147ProGln: 3.147 ± 0.037	4.183ProArg: 4.183 ± 0.033	4.605ProSer: 4.605 ± 0.041	2.592ProThr: 2.592 ± 0.023	3.422ProVal: 3.422 ± 0.03	0.859ProTrp: 0.859 ± 0.012	0.921ProTyr: 0.921 ± 0.014	0.0ProXaa: 0.0 ± 0.0
Gln	5.826GlnAla: 5.826 ± 0.047	0.434GlnCys: 0.434 ± 0.01	1.532GlnAsp: 1.532 ± 0.014	3.049GlnGlu: 3.049 ± 0.042	0.73GlnPhe: 0.73 ± 0.013	3.363GlnGly: 3.363 ± 0.028	1.643GlnHis: 1.643 ± 0.025	0.928GlnIle: 0.928 ± 0.013	1.079GlnLys: 1.079 ± 0.02	5.526GlnLeu: 5.526 ± 0.043	0.764GlnMet: 0.764 ± 0.013	0.54GlnAsn: 0.54 ± 0.011	3.381GlnPro: 3.381 ± 0.041	16.818GlnGln: 16.818 ± 0.263	4.049GlnArg: 4.049 ± 0.034	1.679GlnSer: 1.679 ± 0.017	1.151GlnThr: 1.151 ± 0.015	2.369GlnVal: 2.369 ± 0.021	0.563GlnTrp: 0.563 ± 0.012	0.643GlnTyr: 0.643 ± 0.01	0.0GlnXaa: 0.0 ± 0.0
Arg	10.052ArgAla: 10.052 ± 0.07	1.111ArgCys: 1.111 ± 0.015	3.12ArgAsp: 3.12 ± 0.026	3.771ArgGlu: 3.771 ± 0.035	1.63ArgPhe: 1.63 ± 0.018	6.603ArgGly: 6.603 ± 0.052	1.574ArgHis: 1.574 ± 0.017	1.555ArgIle: 1.555 ± 0.015	1.812ArgLys: 1.812 ± 0.023	7.479ArgLeu: 7.479 ± 0.052	1.308ArgMet: 1.308 ± 0.015	1.12ArgAsn: 1.12 ± 0.014	4.333ArgPro: 4.333 ± 0.035	3.647ArgGln: 3.647 ± 0.031	7.43ArgArg: 7.43 ± 0.059	3.94ArgSer: 3.94 ± 0.032	2.401ArgThr: 2.401 ± 0.023	4.32ArgVal: 4.32 ± 0.031	0.978ArgTrp: 0.978 ± 0.013	1.102ArgTyr: 1.102 ± 0.013	0.0ArgXaa: 0.0 ± 0.0
Ser	8.629SerAla: 8.629 ± 0.044	1.124SerCys: 1.124 ± 0.017	3.091SerAsp: 3.091 ± 0.025	2.832SerGlu: 2.832 ± 0.023	1.791SerPhe: 1.791 ± 0.019	7.916SerGly: 7.916 ± 0.056	1.083SerHis: 1.083 ± 0.014	1.664SerIle: 1.664 ± 0.02	1.987SerLys: 1.987 ± 0.023	5.459SerLeu: 5.459 ± 0.037	1.136SerMet: 1.136 ± 0.015	1.44SerAsn: 1.44 ± 0.02	4.098SerPro: 4.098 ± 0.039	2.085SerGln: 2.085 ± 0.019	3.847SerArg: 3.847 ± 0.032	6.761SerSer: 6.761 ± 0.08	2.857SerThr: 2.857 ± 0.027	3.536SerVal: 3.536 ± 0.03	0.898SerTrp: 0.898 ± 0.013	1.145SerTyr: 1.145 ± 0.016	0.0SerXaa: 0.0 ± 0.0
Thr	6.203ThrAla: 6.203 ± 0.039	0.736ThrCys: 0.736 ± 0.015	1.7ThrAsp: 1.7 ± 0.017	1.539ThrGlu: 1.539 ± 0.019	1.265ThrPhe: 1.265 ± 0.017	3.808ThrGly: 3.808 ± 0.034	0.799ThrHis: 0.799 ± 0.012	1.277ThrIle: 1.277 ± 0.017	1.233ThrLys: 1.233 ± 0.018	4.059ThrLeu: 4.059 ± 0.031	0.688ThrMet: 0.688 ± 0.012	1.006ThrAsn: 1.006 ± 0.018	3.157ThrPro: 3.157 ± 0.03	1.47ThrGln: 1.47 ± 0.017	2.387ThrArg: 2.387 ± 0.021	2.874ThrSer: 2.874 ± 0.026	2.215ThrThr: 2.215 ± 0.028	2.697ThrVal: 2.697 ± 0.029	0.611ThrTrp: 0.611 ± 0.011	0.861ThrTyr: 0.861 ± 0.013	0.0ThrXaa: 0.0 ± 0.0
Val	9.69ValAla: 9.69 ± 0.046	1.023ValCys: 1.023 ± 0.016	3.153ValAsp: 3.153 ± 0.029	3.419ValGlu: 3.419 ± 0.027	1.812ValPhe: 1.812 ± 0.019	5.013ValGly: 5.013 ± 0.034	1.222ValHis: 1.222 ± 0.014	1.783ValIle: 1.783 ± 0.018	1.959ValLys: 1.959 ± 0.021	6.384ValLeu: 6.384 ± 0.041	1.312ValMet: 1.312 ± 0.018	1.379ValAsn: 1.379 ± 0.022	3.683ValPro: 3.683 ± 0.029	2.451ValGln: 2.451 ± 0.022	4.08ValArg: 4.08 ± 0.027	3.77ValSer: 3.77 ± 0.028	3.133ValThr: 3.133 ± 0.032	5.104ValVal: 5.104 ± 0.038	0.866ValTrp: 0.866 ± 0.014	1.23ValTyr: 1.23 ± 0.017	0.0ValXaa: 0.0 ± 0.0
Trp	1.688TrpAla: 1.688 ± 0.019	0.231TrpCys: 0.231 ± 0.007	0.718TrpAsp: 0.718 ± 0.011	0.74TrpGlu: 0.74 ± 0.012	0.357TrpPhe: 0.357 ± 0.008	1.229TrpGly: 1.229 ± 0.016	0.31TrpHis: 0.31 ± 0.008	0.276TrpIle: 0.276 ± 0.007	0.308TrpLys: 0.308 ± 0.007	1.469TrpLeu: 1.469 ± 0.017	0.299TrpMet: 0.299 ± 0.008	0.269TrpAsn: 0.269 ± 0.008	0.74TrpPro: 0.74 ± 0.013	0.732TrpGln: 0.732 ± 0.012	1.365TrpArg: 1.365 ± 0.019	0.78TrpSer: 0.78 ± 0.012	0.517TrpThr: 0.517 ± 0.009	0.854TrpVal: 0.854 ± 0.012	0.275TrpTrp: 0.275 ± 0.008	0.25TrpTyr: 0.25 ± 0.007	0.0TrpXaa: 0.0 ± 0.0
Tyr	1.85TyrAla: 1.85 ± 0.018	0.345TyrCys: 0.345 ± 0.008	1.009TyrAsp: 1.009 ± 0.014	0.923TyrGlu: 0.923 ± 0.015	0.551TyrPhe: 0.551 ± 0.01	1.571TyrGly: 1.571 ± 0.02	0.361TyrHis: 0.361 ± 0.009	0.536TyrIle: 0.536 ± 0.01	0.625TyrLys: 0.625 ± 0.011	1.494TyrLeu: 1.494 ± 0.019	0.362TyrMet: 0.362 ± 0.01	0.555TyrAsn: 0.555 ± 0.012	0.805TyrPro: 0.805 ± 0.013	0.625TyrGln: 0.625 ± 0.01	1.0TyrArg: 1.0 ± 0.013	1.176TyrSer: 1.176 ± 0.017	0.905TyrThr: 0.905 ± 0.015	1.182TyrVal: 1.182 ± 0.016	0.263TyrTrp: 0.263 ± 0.006	0.494TyrTyr: 0.494 ± 0.009	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 16738 proteins (5818762 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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