Amino acid dipepetide frequency for Caulobacteraceae bacterium OTSz_A_272

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	19.486AlaAla: 19.486 ± 0.208	1.305AlaCys: 1.305 ± 0.035	7.053AlaAsp: 7.053 ± 0.093	7.939AlaGlu: 7.939 ± 0.102	5.076AlaPhe: 5.076 ± 0.087	10.545AlaGly: 10.545 ± 0.116	2.68AlaHis: 2.68 ± 0.056	6.745AlaIle: 6.745 ± 0.085	4.045AlaLys: 4.045 ± 0.089	14.883AlaLeu: 14.883 ± 0.155	3.532AlaMet: 3.532 ± 0.066	3.694AlaAsn: 3.694 ± 0.062	7.558AlaPro: 7.558 ± 0.109	5.266AlaGln: 5.266 ± 0.086	10.461AlaArg: 10.461 ± 0.133	7.155AlaSer: 7.155 ± 0.087	6.107AlaThr: 6.107 ± 0.101	8.364AlaVal: 8.364 ± 0.083	1.819AlaTrp: 1.819 ± 0.042	2.903AlaTyr: 2.903 ± 0.057	0.0AlaXaa: 0.0 ± 0.0
Cys	1.238CysAla: 1.238 ± 0.033	0.089CysCys: 0.089 ± 0.009	0.497CysAsp: 0.497 ± 0.024	0.459CysGlu: 0.459 ± 0.019	0.304CysPhe: 0.304 ± 0.017	0.841CysGly: 0.841 ± 0.033	0.155CysHis: 0.155 ± 0.012	0.356CysIle: 0.356 ± 0.018	0.174CysLys: 0.174 ± 0.013	0.677CysLeu: 0.677 ± 0.024	0.142CysMet: 0.142 ± 0.012	0.217CysAsn: 0.217 ± 0.015	0.395CysPro: 0.395 ± 0.022	0.198CysGln: 0.198 ± 0.014	0.517CysArg: 0.517 ± 0.023	0.418CysSer: 0.418 ± 0.02	0.415CysThr: 0.415 ± 0.021	0.634CysVal: 0.634 ± 0.023	0.106CysTrp: 0.106 ± 0.009	0.206CysTyr: 0.206 ± 0.015	0.0CysXaa: 0.0 ± 0.0
Asp	8.012AspAla: 8.012 ± 0.101	0.442AspCys: 0.442 ± 0.022	3.168AspAsp: 3.168 ± 0.057	3.569AspGlu: 3.569 ± 0.064	2.136AspPhe: 2.136 ± 0.048	5.228AspGly: 5.228 ± 0.101	1.082AspHis: 1.082 ± 0.031	2.806AspIle: 2.806 ± 0.059	1.454AspLys: 1.454 ± 0.043	5.451AspLeu: 5.451 ± 0.077	1.208AspMet: 1.208 ± 0.031	1.418AspAsn: 1.418 ± 0.039	3.347AspPro: 3.347 ± 0.063	1.775AspGln: 1.775 ± 0.045	4.005AspArg: 4.005 ± 0.067	2.091AspSer: 2.091 ± 0.044	2.633AspThr: 2.633 ± 0.071	4.373AspVal: 4.373 ± 0.062	0.995AspTrp: 0.995 ± 0.031	1.418AspTyr: 1.418 ± 0.041	0.0AspXaa: 0.0 ± 0.0
Glu	8.392GluAla: 8.392 ± 0.116	0.366GluCys: 0.366 ± 0.019	2.857GluAsp: 2.857 ± 0.047	3.322GluGlu: 3.322 ± 0.064	1.859GluPhe: 1.859 ± 0.046	4.583GluGly: 4.583 ± 0.072	1.278GluHis: 1.278 ± 0.031	3.528GluIle: 3.528 ± 0.054	1.82GluLys: 1.82 ± 0.054	5.464GluLeu: 5.464 ± 0.085	1.436GluMet: 1.436 ± 0.034	1.62GluAsn: 1.62 ± 0.042	2.796GluPro: 2.796 ± 0.055	2.307GluGln: 2.307 ± 0.044	5.695GluArg: 5.695 ± 0.083	2.527GluSer: 2.527 ± 0.051	3.556GluThr: 3.556 ± 0.058	3.684GluVal: 3.684 ± 0.064	0.757GluTrp: 0.757 ± 0.026	1.074GluTyr: 1.074 ± 0.031	0.0GluXaa: 0.0 ± 0.0
Phe	5.357PheAla: 5.357 ± 0.084	0.402PheCys: 0.402 ± 0.02	2.716PheAsp: 2.716 ± 0.051	2.513PheGlu: 2.513 ± 0.044	1.456PhePhe: 1.456 ± 0.044	3.67PheGly: 3.67 ± 0.066	0.668PheHis: 0.668 ± 0.025	1.718PheIle: 1.718 ± 0.042	0.974PheLys: 0.974 ± 0.031	3.093PheLeu: 3.093 ± 0.056	0.796PheMet: 0.796 ± 0.028	1.265PheAsn: 1.265 ± 0.036	1.492PhePro: 1.492 ± 0.039	1.045PheGln: 1.045 ± 0.03	2.087PheArg: 2.087 ± 0.041	2.271PheSer: 2.271 ± 0.053	2.092PheThr: 2.092 ± 0.047	2.905PheVal: 2.905 ± 0.056	0.569PheTrp: 0.569 ± 0.026	0.893PheTyr: 0.893 ± 0.03	0.0PheXaa: 0.0 ± 0.0
Gly	12.397GlyAla: 12.397 ± 0.132	0.696GlyCys: 0.696 ± 0.026	5.028GlyAsp: 5.028 ± 0.073	5.223GlyGlu: 5.223 ± 0.072	3.54GlyPhe: 3.54 ± 0.058	8.058GlyGly: 8.058 ± 0.155	1.599GlyHis: 1.599 ± 0.042	3.524GlyIle: 3.524 ± 0.066	2.649GlyLys: 2.649 ± 0.071	7.9GlyLeu: 7.9 ± 0.099	1.965GlyMet: 1.965 ± 0.042	2.062GlyAsn: 2.062 ± 0.074	3.55GlyPro: 3.55 ± 0.062	2.813GlyGln: 2.813 ± 0.056	5.978GlyArg: 5.978 ± 0.089	3.981GlySer: 3.981 ± 0.073	2.988GlyThr: 2.988 ± 0.063	7.184GlyVal: 7.184 ± 0.084	1.389GlyTrp: 1.389 ± 0.041	2.174GlyTyr: 2.174 ± 0.045	0.0GlyXaa: 0.0 ± 0.0
His	2.44HisAla: 2.44 ± 0.053	0.192HisCys: 0.192 ± 0.015	1.15HisAsp: 1.15 ± 0.031	1.158HisGlu: 1.158 ± 0.032	0.773HisPhe: 0.773 ± 0.027	1.75HisGly: 1.75 ± 0.044	0.451HisHis: 0.451 ± 0.022	0.861HisIle: 0.861 ± 0.028	0.504HisLys: 0.504 ± 0.022	1.821HisLeu: 1.821 ± 0.043	0.443HisMet: 0.443 ± 0.02	0.494HisAsn: 0.494 ± 0.023	1.125HisPro: 1.125 ± 0.032	0.553HisGln: 0.553 ± 0.022	1.261HisArg: 1.261 ± 0.036	0.874HisSer: 0.874 ± 0.028	0.772HisThr: 0.772 ± 0.027	1.484HisVal: 1.484 ± 0.037	0.295HisTrp: 0.295 ± 0.016	0.549HisTyr: 0.549 ± 0.024	0.0HisXaa: 0.0 ± 0.0
Ile	7.72IleAla: 7.72 ± 0.098	0.487IleCys: 0.487 ± 0.019	3.527IleAsp: 3.527 ± 0.06	3.772IleGlu: 3.772 ± 0.058	1.737IlePhe: 1.737 ± 0.047	4.991IleGly: 4.991 ± 0.081	0.804IleHis: 0.804 ± 0.025	2.324IleIle: 2.324 ± 0.056	1.281IleLys: 1.281 ± 0.037	3.731IleLeu: 3.731 ± 0.065	0.887IleMet: 0.887 ± 0.032	1.423IleAsn: 1.423 ± 0.038	1.972IlePro: 1.972 ± 0.046	1.252IleGln: 1.252 ± 0.03	2.785IleArg: 2.785 ± 0.052	2.899IleSer: 2.899 ± 0.052	2.667IleThr: 2.667 ± 0.045	4.258IleVal: 4.258 ± 0.066	0.669IleTrp: 0.669 ± 0.026	1.106IleTyr: 1.106 ± 0.03	0.0IleXaa: 0.0 ± 0.0
Lys	3.576LysAla: 3.576 ± 0.081	0.16LysCys: 0.16 ± 0.013	1.444LysAsp: 1.444 ± 0.046	1.375LysGlu: 1.375 ± 0.038	0.947LysPhe: 0.947 ± 0.031	2.107LysGly: 2.107 ± 0.053	0.628LysHis: 0.628 ± 0.024	1.459LysIle: 1.459 ± 0.048	1.27LysLys: 1.27 ± 0.05	3.23LysLeu: 3.23 ± 0.068	0.641LysMet: 0.641 ± 0.027	0.811LysAsn: 0.811 ± 0.03	1.849LysPro: 1.849 ± 0.052	0.996LysGln: 0.996 ± 0.034	2.648LysArg: 2.648 ± 0.063	1.625LysSer: 1.625 ± 0.047	1.533LysThr: 1.533 ± 0.039	1.89LysVal: 1.89 ± 0.053	0.355LysTrp: 0.355 ± 0.02	0.562LysTyr: 0.562 ± 0.024	0.0LysXaa: 0.0 ± 0.0
Leu	13.588LeuAla: 13.588 ± 0.141	0.742LeuCys: 0.742 ± 0.028	5.609LeuAsp: 5.609 ± 0.094	5.445LeuGlu: 5.445 ± 0.077	3.496LeuPhe: 3.496 ± 0.068	7.874LeuGly: 7.874 ± 0.105	1.671LeuHis: 1.671 ± 0.041	5.119LeuIle: 5.119 ± 0.087	3.228LeuLys: 3.228 ± 0.063	8.256LeuLeu: 8.256 ± 0.126	2.263LeuMet: 2.263 ± 0.047	2.931LeuAsn: 2.931 ± 0.047	4.497LeuPro: 4.497 ± 0.064	2.938LeuGln: 2.938 ± 0.054	6.997LeuArg: 6.997 ± 0.088	6.001LeuSer: 6.001 ± 0.075	5.503LeuThr: 5.503 ± 0.085	6.511LeuVal: 6.511 ± 0.094	1.188LeuTrp: 1.188 ± 0.037	1.96LeuTyr: 1.96 ± 0.043	0.0LeuXaa: 0.0 ± 0.0
Met	2.891MetAla: 2.891 ± 0.058	0.161MetCys: 0.161 ± 0.012	1.042MetAsp: 1.042 ± 0.037	1.021MetGlu: 1.021 ± 0.028	0.826MetPhe: 0.826 ± 0.026	1.688MetGly: 1.688 ± 0.044	0.47MetHis: 0.47 ± 0.023	1.238MetIle: 1.238 ± 0.037	0.866MetLys: 0.866 ± 0.028	2.312MetLeu: 2.312 ± 0.052	0.59MetMet: 0.59 ± 0.026	0.771MetAsn: 0.771 ± 0.027	1.231MetPro: 1.231 ± 0.035	0.914MetGln: 0.914 ± 0.03	2.134MetArg: 2.134 ± 0.041	1.785MetSer: 1.785 ± 0.04	1.608MetThr: 1.608 ± 0.041	1.37MetVal: 1.37 ± 0.034	0.252MetTrp: 0.252 ± 0.015	0.3MetTyr: 0.3 ± 0.017	0.0MetXaa: 0.0 ± 0.0
Asn	4.025AsnAla: 4.025 ± 0.065	0.216AsnCys: 0.216 ± 0.015	1.654AsnAsp: 1.654 ± 0.057	1.549AsnGlu: 1.549 ± 0.035	1.059AsnPhe: 1.059 ± 0.032	2.77AsnGly: 2.77 ± 0.066	0.474AsnHis: 0.474 ± 0.019	1.337AsnIle: 1.337 ± 0.034	0.605AsnLys: 0.605 ± 0.026	2.487AsnLeu: 2.487 ± 0.052	0.629AsnMet: 0.629 ± 0.026	0.825AsnAsn: 0.825 ± 0.03	1.74AsnPro: 1.74 ± 0.039	0.836AsnGln: 0.836 ± 0.027	1.793AsnArg: 1.793 ± 0.042	1.292AsnSer: 1.292 ± 0.035	1.423AsnThr: 1.423 ± 0.037	2.31AsnVal: 2.31 ± 0.048	0.48AsnTrp: 0.48 ± 0.021	0.7AsnTyr: 0.7 ± 0.029	0.0AsnXaa: 0.0 ± 0.0
Pro	6.312ProAla: 6.312 ± 0.093	0.29ProCys: 0.29 ± 0.014	3.193ProAsp: 3.193 ± 0.057	3.428ProGlu: 3.428 ± 0.064	1.944ProPhe: 1.944 ± 0.045	4.137ProGly: 4.137 ± 0.065	1.008ProHis: 1.008 ± 0.027	2.562ProIle: 2.562 ± 0.046	1.6ProLys: 1.6 ± 0.049	4.421ProLeu: 4.421 ± 0.071	1.165ProMet: 1.165 ± 0.035	1.649ProAsn: 1.649 ± 0.037	3.088ProPro: 3.088 ± 0.092	1.909ProGln: 1.909 ± 0.05	3.238ProArg: 3.238 ± 0.06	2.894ProSer: 2.894 ± 0.056	2.557ProThr: 2.557 ± 0.049	3.538ProVal: 3.538 ± 0.064	0.721ProTrp: 0.721 ± 0.028	1.083ProTyr: 1.083 ± 0.034	0.0ProXaa: 0.0 ± 0.0
Gln	4.621GlnAla: 4.621 ± 0.089	0.245GlnCys: 0.245 ± 0.015	1.446GlnAsp: 1.446 ± 0.036	1.632GlnGlu: 1.632 ± 0.039	1.202GlnPhe: 1.202 ± 0.033	2.565GlnGly: 2.565 ± 0.052	0.714GlnHis: 0.714 ± 0.025	1.962GlnIle: 1.962 ± 0.066	0.875GlnLys: 0.875 ± 0.032	3.185GlnLeu: 3.185 ± 0.059	0.842GlnMet: 0.842 ± 0.029	0.947GlnAsn: 0.947 ± 0.032	1.802GlnPro: 1.802 ± 0.051	1.353GlnGln: 1.353 ± 0.044	3.005GlnArg: 3.005 ± 0.059	1.996GlnSer: 1.996 ± 0.044	2.03GlnThr: 2.03 ± 0.045	2.165GlnVal: 2.165 ± 0.073	0.47GlnTrp: 0.47 ± 0.023	0.607GlnTyr: 0.607 ± 0.022	0.0GlnXaa: 0.0 ± 0.0
Arg	10.12ArgAla: 10.12 ± 0.129	0.504ArgCys: 0.504 ± 0.021	4.514ArgAsp: 4.514 ± 0.081	4.585ArgGlu: 4.585 ± 0.072	3.074ArgPhe: 3.074 ± 0.05	5.536ArgGly: 5.536 ± 0.08	1.296ArgHis: 1.296 ± 0.039	3.899ArgIle: 3.899 ± 0.059	2.035ArgLys: 2.035 ± 0.045	7.436ArgLeu: 7.436 ± 0.085	1.938ArgMet: 1.938 ± 0.047	1.974ArgAsn: 1.974 ± 0.043	3.356ArgPro: 3.356 ± 0.064	2.556ArgGln: 2.556 ± 0.055	5.963ArgArg: 5.963 ± 0.106	3.669ArgSer: 3.669 ± 0.061	3.779ArgThr: 3.779 ± 0.057	5.422ArgVal: 5.422 ± 0.079	1.132ArgTrp: 1.132 ± 0.033	1.821ArgTyr: 1.821 ± 0.047	0.0ArgXaa: 0.0 ± 0.0
Ser	7.099SerAla: 7.099 ± 0.103	0.374SerCys: 0.374 ± 0.019	2.989SerAsp: 2.989 ± 0.054	3.098SerGlu: 3.098 ± 0.055	2.282SerPhe: 2.282 ± 0.045	5.226SerGly: 5.226 ± 0.074	1.017SerHis: 1.017 ± 0.033	2.681SerIle: 2.681 ± 0.053	1.468SerLys: 1.468 ± 0.038	5.134SerLeu: 5.134 ± 0.069	1.35SerMet: 1.35 ± 0.033	1.555SerAsn: 1.555 ± 0.038	2.782SerPro: 2.782 ± 0.048	1.679SerGln: 1.679 ± 0.044	3.5SerArg: 3.5 ± 0.063	2.937SerSer: 2.937 ± 0.061	2.634SerThr: 2.634 ± 0.053	3.727SerVal: 3.727 ± 0.059	0.784SerTrp: 0.784 ± 0.024	1.265SerTyr: 1.265 ± 0.034	0.0SerXaa: 0.0 ± 0.0
Thr	5.934ThrAla: 5.934 ± 0.083	0.377ThrCys: 0.377 ± 0.019	2.561ThrAsp: 2.561 ± 0.049	2.413ThrGlu: 2.413 ± 0.048	1.988ThrPhe: 1.988 ± 0.05	4.571ThrGly: 4.571 ± 0.082	0.978ThrHis: 0.978 ± 0.033	2.662ThrIle: 2.662 ± 0.057	1.346ThrLys: 1.346 ± 0.035	5.579ThrLeu: 5.579 ± 0.078	1.142ThrMet: 1.142 ± 0.033	1.417ThrAsn: 1.417 ± 0.051	3.746ThrPro: 3.746 ± 0.048	1.951ThrGln: 1.951 ± 0.12	3.644ThrArg: 3.644 ± 0.064	2.859ThrSer: 2.859 ± 0.063	2.752ThrThr: 2.752 ± 0.082	3.311ThrVal: 3.311 ± 0.059	0.717ThrTrp: 0.717 ± 0.026	1.173ThrTyr: 1.173 ± 0.029	0.0ThrXaa: 0.0 ± 0.0
Val	9.054ValAla: 9.054 ± 0.097	0.639ValCys: 0.639 ± 0.024	4.0ValAsp: 4.0 ± 0.064	4.425ValGlu: 4.425 ± 0.074	2.795ValPhe: 2.795 ± 0.055	5.498ValGly: 5.498 ± 0.085	1.304ValHis: 1.304 ± 0.036	3.903ValIle: 3.903 ± 0.061	1.993ValLys: 1.993 ± 0.057	7.099ValLeu: 7.099 ± 0.095	1.717ValMet: 1.717 ± 0.039	2.011ValAsn: 2.011 ± 0.04	2.73ValPro: 2.73 ± 0.053	2.134ValGln: 2.134 ± 0.04	5.546ValArg: 5.546 ± 0.07	4.228ValSer: 4.228 ± 0.066	4.163ValThr: 4.163 ± 0.065	5.547ValVal: 5.547 ± 0.085	1.019ValTrp: 1.019 ± 0.034	1.406ValTyr: 1.406 ± 0.039	0.0ValXaa: 0.0 ± 0.0
Trp	1.564TrpAla: 1.564 ± 0.041	0.135TrpCys: 0.135 ± 0.012	0.741TrpAsp: 0.741 ± 0.026	0.585TrpGlu: 0.585 ± 0.025	0.558TrpPhe: 0.558 ± 0.024	1.045TrpGly: 1.045 ± 0.035	0.24TrpHis: 0.24 ± 0.012	0.775TrpIle: 0.775 ± 0.026	0.396TrpLys: 0.396 ± 0.02	1.61TrpLeu: 1.61 ± 0.046	0.37TrpMet: 0.37 ± 0.019	0.453TrpAsn: 0.453 ± 0.022	0.718TrpPro: 0.718 ± 0.027	0.422TrpGln: 0.422 ± 0.018	1.608TrpArg: 1.608 ± 0.044	0.96TrpSer: 0.96 ± 0.028	0.827TrpThr: 0.827 ± 0.026	0.841TrpVal: 0.841 ± 0.027	0.234TrpTrp: 0.234 ± 0.018	0.251TrpTyr: 0.251 ± 0.018	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.788TyrAla: 2.788 ± 0.05	0.217TyrCys: 0.217 ± 0.014	1.422TyrAsp: 1.422 ± 0.036	1.413TyrGlu: 1.413 ± 0.034	0.931TyrPhe: 0.931 ± 0.032	2.013TyrGly: 2.013 ± 0.044	0.436TyrHis: 0.436 ± 0.023	0.828TyrIle: 0.828 ± 0.03	0.524TyrLys: 0.524 ± 0.023	2.047TyrLeu: 2.047 ± 0.046	0.414TyrMet: 0.414 ± 0.021	0.671TyrAsn: 0.671 ± 0.025	0.963TyrPro: 0.963 ± 0.028	0.768TyrGln: 0.768 ± 0.031	1.741TyrArg: 1.741 ± 0.049	1.121TyrSer: 1.121 ± 0.033	1.081TyrThr: 1.081 ± 0.035	1.694TyrVal: 1.694 ± 0.041	0.38TyrTrp: 0.38 ± 0.017	0.584TyrTyr: 0.584 ± 0.026	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3743 proteins (1113520 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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