Amino acid dipepetide frequency for Ageratum yellow vein virus-Ishigaki

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
6.381AlaAla: 6.381 ± 1.889
1.823AlaCys: 1.823 ± 1.224
0.912AlaAsp: 0.912 ± 0.699
0.912AlaGlu: 0.912 ± 0.676
0.912AlaPhe: 0.912 ± 0.844
0.0AlaGly: 0.0 ± 0.0
1.823AlaHis: 1.823 ± 1.023
1.823AlaIle: 1.823 ± 0.847
3.646AlaLys: 3.646 ± 1.103
7.293AlaLeu: 7.293 ± 1.885
1.823AlaMet: 1.823 ± 0.667
2.735AlaAsn: 2.735 ± 1.28
5.469AlaPro: 5.469 ± 1.727
3.646AlaGln: 3.646 ± 1.936
4.558AlaArg: 4.558 ± 2.106
4.558AlaSer: 4.558 ± 1.909
2.735AlaThr: 2.735 ± 1.665
1.823AlaVal: 1.823 ± 1.294
0.912AlaTrp: 0.912 ± 0.676
0.912AlaTyr: 0.912 ± 0.676
0.0AlaXaa: 0.0 ± 0.0
Cys
0.912CysAla: 0.912 ± 0.844
1.823CysCys: 1.823 ± 2.065
0.912CysAsp: 0.912 ± 1.096
1.823CysGlu: 1.823 ± 1.224
0.912CysPhe: 0.912 ± 1.096
1.823CysGly: 1.823 ± 0.847
0.912CysHis: 0.912 ± 1.033
0.0CysIle: 0.0 ± 0.0
1.823CysLys: 1.823 ± 0.66
0.912CysLeu: 0.912 ± 1.003
1.823CysMet: 1.823 ± 1.496
1.823CysAsn: 1.823 ± 0.847
2.735CysPro: 2.735 ± 1.941
0.0CysGln: 0.0 ± 0.0
0.912CysArg: 0.912 ± 0.676
1.823CysSer: 1.823 ± 0.847
1.823CysThr: 1.823 ± 1.145
1.823CysVal: 1.823 ± 1.399
0.0CysTrp: 0.0 ± 0.0
0.0CysTyr: 0.0 ± 0.0
0.0CysXaa: 0.0 ± 0.0
Asp
1.823AspAla: 1.823 ± 1.352
0.912AspCys: 0.912 ± 0.844
1.823AspAsp: 1.823 ± 1.221
2.735AspGlu: 2.735 ± 0.966
1.823AspPhe: 1.823 ± 1.224
2.735AspGly: 2.735 ± 2.028
0.912AspHis: 0.912 ± 1.096
2.735AspIle: 2.735 ± 1.665
0.912AspLys: 0.912 ± 0.676
9.116AspLeu: 9.116 ± 3.203
0.912AspMet: 0.912 ± 1.033
4.558AspAsn: 4.558 ± 2.229
1.823AspPro: 1.823 ± 1.023
2.735AspGln: 2.735 ± 1.112
2.735AspArg: 2.735 ± 1.18
3.646AspSer: 3.646 ± 1.094
3.646AspThr: 3.646 ± 1.147
4.558AspVal: 4.558 ± 1.14
0.912AspTrp: 0.912 ± 0.676
0.912AspTyr: 0.912 ± 0.676
0.0AspXaa: 0.0 ± 0.0
Glu
4.558GluAla: 4.558 ± 1.08
0.0GluCys: 0.0 ± 0.0
1.823GluAsp: 1.823 ± 1.221
7.293GluGlu: 7.293 ± 3.931
3.646GluPhe: 3.646 ± 1.936
3.646GluGly: 3.646 ± 1.147
0.0GluHis: 0.0 ± 0.0
0.0GluIle: 0.0 ± 0.0
0.912GluLys: 0.912 ± 0.676
5.469GluLeu: 5.469 ± 1.907
0.0GluMet: 0.0 ± 0.0
3.646GluAsn: 3.646 ± 1.257
1.823GluPro: 1.823 ± 1.21
2.735GluGln: 2.735 ± 1.685
0.912GluArg: 0.912 ± 1.096
1.823GluSer: 1.823 ± 1.288
2.735GluThr: 2.735 ± 1.296
0.912GluVal: 0.912 ± 0.676
3.646GluTrp: 3.646 ± 1.863
1.823GluTyr: 1.823 ± 1.015
0.0GluXaa: 0.0 ± 0.0
Phe
0.912PheAla: 0.912 ± 0.676
0.912PheCys: 0.912 ± 0.699
2.735PheAsp: 2.735 ± 1.138
0.912PheGlu: 0.912 ± 0.676
0.912PhePhe: 0.912 ± 0.676
2.735PheGly: 2.735 ± 1.7
2.735PheHis: 2.735 ± 1.393
0.912PheIle: 0.912 ± 0.676
2.735PheLys: 2.735 ± 1.331
5.469PheLeu: 5.469 ± 1.999
1.823PheMet: 1.823 ± 0.66
3.646PheAsn: 3.646 ± 3.275
0.912PhePro: 0.912 ± 1.033
2.735PheGln: 2.735 ± 1.018
4.558PheArg: 4.558 ± 2.952
1.823PheSer: 1.823 ± 1.688
0.912PheThr: 0.912 ± 0.699
0.912PheVal: 0.912 ± 0.676
0.0PheTrp: 0.0 ± 0.0
1.823PheTyr: 1.823 ± 1.399
0.0PheXaa: 0.0 ± 0.0
Gly
3.646GlyAla: 3.646 ± 2.28
1.823GlyCys: 1.823 ± 1.145
1.823GlyAsp: 1.823 ± 1.352
1.823GlyGlu: 1.823 ± 1.015
1.823GlyPhe: 1.823 ± 1.307
2.735GlyGly: 2.735 ± 1.138
2.735GlyHis: 2.735 ± 1.112
3.646GlyIle: 3.646 ± 1.57
5.469GlyLys: 5.469 ± 1.98
0.912GlyLeu: 0.912 ± 0.699
0.0GlyMet: 0.0 ± 0.0
2.735GlyAsn: 2.735 ± 1.294
2.735GlyPro: 2.735 ± 1.138
3.646GlyGln: 3.646 ± 1.211
0.912GlyArg: 0.912 ± 0.676
1.823GlySer: 1.823 ± 1.352
2.735GlyThr: 2.735 ± 0.966
2.735GlyVal: 2.735 ± 2.377
0.0GlyTrp: 0.0 ± 0.0
0.0GlyTyr: 0.0 ± 0.0
0.0GlyXaa: 0.0 ± 0.0
His
0.912HisAla: 0.912 ± 0.699
2.735HisCys: 2.735 ± 1.942
2.735HisAsp: 2.735 ± 1.563
1.823HisGlu: 1.823 ± 1.015
2.735HisPhe: 2.735 ± 1.393
1.823HisGly: 1.823 ± 1.307
1.823HisHis: 1.823 ± 1.288
1.823HisIle: 1.823 ± 1.458
0.0HisLys: 0.0 ± 0.0
2.735HisLeu: 2.735 ± 1.699
0.0HisMet: 0.0 ± 0.0
3.646HisAsn: 3.646 ± 1.152
1.823HisPro: 1.823 ± 1.023
3.646HisGln: 3.646 ± 1.714
2.735HisArg: 2.735 ± 1.886
0.912HisSer: 0.912 ± 1.033
1.823HisThr: 1.823 ± 1.399
3.646HisVal: 3.646 ± 1.133
0.0HisTrp: 0.0 ± 0.0
0.912HisTyr: 0.912 ± 0.676
0.0HisXaa: 0.0 ± 0.0
Ile
0.912IleAla: 0.912 ± 0.844
0.912IleCys: 0.912 ± 0.676
3.646IleAsp: 3.646 ± 1.863
0.912IleGlu: 0.912 ± 0.676
3.646IlePhe: 3.646 ± 1.152
0.912IleGly: 0.912 ± 1.033
0.912IleHis: 0.912 ± 1.096
2.735IleIle: 2.735 ± 3.289
9.116IleLys: 9.116 ± 2.378
0.0IleLeu: 0.0 ± 0.0
0.912IleMet: 0.912 ± 0.785
2.735IleAsn: 2.735 ± 0.903
0.912IlePro: 0.912 ± 0.676
5.469IleGln: 5.469 ± 2.156
5.469IleArg: 5.469 ± 2.905
8.204IleSer: 8.204 ± 2.469
3.646IleThr: 3.646 ± 1.35
1.823IleVal: 1.823 ± 0.66
1.823IleTrp: 1.823 ± 1.224
1.823IleTyr: 1.823 ± 1.145
0.0IleXaa: 0.0 ± 0.0
Lys
0.912LysAla: 0.912 ± 1.096
0.0LysCys: 0.0 ± 0.0
2.735LysAsp: 2.735 ± 1.393
5.469LysGlu: 5.469 ± 3.059
2.735LysPhe: 2.735 ± 1.665
2.735LysGly: 2.735 ± 0.995
1.823LysHis: 1.823 ± 1.015
5.469LysIle: 5.469 ± 1.591
2.735LysLys: 2.735 ± 0.966
0.0LysLeu: 0.0 ± 0.0
0.0LysMet: 0.0 ± 0.0
6.381LysAsn: 6.381 ± 1.866
1.823LysPro: 1.823 ± 0.66
0.0LysGln: 0.0 ± 0.0
2.735LysArg: 2.735 ± 1.7
5.469LysSer: 5.469 ± 1.853
1.823LysThr: 1.823 ± 0.66
4.558LysVal: 4.558 ± 1.98
0.0LysTrp: 0.0 ± 0.0
5.469LysTyr: 5.469 ± 1.306
0.0LysXaa: 0.0 ± 0.0
Leu
2.735LeuAla: 2.735 ± 1.112
2.735LeuCys: 2.735 ± 1.138
5.469LeuAsp: 5.469 ± 2.56
4.558LeuGlu: 4.558 ± 1.741
0.0LeuPhe: 0.0 ± 0.0
3.646LeuGly: 3.646 ± 1.897
1.823LeuHis: 1.823 ± 1.352
5.469LeuIle: 5.469 ± 2.061
3.646LeuLys: 3.646 ± 1.103
4.558LeuLeu: 4.558 ± 1.787
0.912LeuMet: 0.912 ± 1.003
7.293LeuAsn: 7.293 ± 1.854
1.823LeuPro: 1.823 ± 1.247
3.646LeuGln: 3.646 ± 1.464
4.558LeuArg: 4.558 ± 2.61
3.646LeuSer: 3.646 ± 2.28
7.293LeuThr: 7.293 ± 2.039
3.646LeuVal: 3.646 ± 2.279
0.912LeuTrp: 0.912 ± 1.096
5.469LeuTyr: 5.469 ± 2.02
0.0LeuXaa: 0.0 ± 0.0
Met
1.823MetAla: 1.823 ± 0.66
0.0MetCys: 0.0 ± 0.0
4.558MetAsp: 4.558 ± 1.787
0.0MetGlu: 0.0 ± 0.0
0.912MetPhe: 0.912 ± 0.699
1.823MetGly: 1.823 ± 1.221
0.0MetHis: 0.0 ± 0.0
0.0MetIle: 0.0 ± 0.0
1.823MetLys: 1.823 ± 1.224
0.912MetLeu: 0.912 ± 1.033
0.0MetMet: 0.0 ± 0.813
0.0MetAsn: 0.0 ± 0.0
0.0MetPro: 0.0 ± 0.0
0.0MetGln: 0.0 ± 0.0
1.823MetArg: 1.823 ± 1.688
1.823MetSer: 1.823 ± 1.399
0.912MetThr: 0.912 ± 1.003
0.0MetVal: 0.0 ± 0.0
1.823MetTrp: 1.823 ± 1.023
2.735MetTyr: 2.735 ± 2.098
0.0MetXaa: 0.0 ± 0.0
Asn
3.646AsnAla: 3.646 ± 1.752
0.0AsnCys: 0.0 ± 0.0
3.646AsnAsp: 3.646 ± 1.103
1.823AsnGlu: 1.823 ± 1.21
0.912AsnPhe: 0.912 ± 0.699
1.823AsnGly: 1.823 ± 1.008
5.469AsnHis: 5.469 ± 2.929
1.823AsnIle: 1.823 ± 0.66
0.912AsnLys: 0.912 ± 0.676
4.558AsnLeu: 4.558 ± 2.979
1.823AsnMet: 1.823 ± 1.324
3.646AsnAsn: 3.646 ± 1.897
4.558AsnPro: 4.558 ± 1.164
2.735AsnGln: 2.735 ± 1.55
4.558AsnArg: 4.558 ± 1.357
5.469AsnSer: 5.469 ± 1.749
6.381AsnThr: 6.381 ± 2.192
4.558AsnVal: 4.558 ± 1.741
0.0AsnTrp: 0.0 ± 0.0
3.646AsnTyr: 3.646 ± 1.147
0.0AsnXaa: 0.0 ± 0.0
Pro
2.735ProAla: 2.735 ± 1.416
1.823ProCys: 1.823 ± 1.21
2.735ProAsp: 2.735 ± 1.488
2.735ProGlu: 2.735 ± 1.112
3.646ProPhe: 3.646 ± 1.023
1.823ProGly: 1.823 ± 1.221
3.646ProHis: 3.646 ± 1.936
4.558ProIle: 4.558 ± 1.899
2.735ProLys: 2.735 ± 1.138
4.558ProLeu: 4.558 ± 1.56
2.735ProMet: 2.735 ± 1.223
0.912ProAsn: 0.912 ± 0.676
1.823ProPro: 1.823 ± 1.352
2.735ProGln: 2.735 ± 1.261
6.381ProArg: 6.381 ± 2.208
4.558ProSer: 4.558 ± 1.107
4.558ProThr: 4.558 ± 1.917
3.646ProVal: 3.646 ± 2.29
0.912ProTrp: 0.912 ± 0.676
0.0ProTyr: 0.0 ± 0.0
0.0ProXaa: 0.0 ± 0.0
Gln
6.381GlnAla: 6.381 ± 1.902
4.558GlnCys: 4.558 ± 2.979
0.912GlnAsp: 0.912 ± 0.844
1.823GlnGlu: 1.823 ± 1.008
2.735GlnPhe: 2.735 ± 1.331
0.912GlnGly: 0.912 ± 0.676
2.735GlnHis: 2.735 ± 1.878
3.646GlnIle: 3.646 ± 1.851
1.823GlnLys: 1.823 ± 1.307
0.912GlnLeu: 0.912 ± 1.033
0.0GlnMet: 0.0 ± 0.0
4.558GlnAsn: 4.558 ± 1.948
3.646GlnPro: 3.646 ± 2.034
2.735GlnGln: 2.735 ± 1.941
2.735GlnArg: 2.735 ± 0.995
3.646GlnSer: 3.646 ± 1.103
3.646GlnThr: 3.646 ± 2.069
3.646GlnVal: 3.646 ± 1.369
0.0GlnTrp: 0.0 ± 0.0
0.912GlnTyr: 0.912 ± 0.699
0.0GlnXaa: 0.0 ± 0.0
Arg
2.735ArgAla: 2.735 ± 1.563
0.912ArgCys: 0.912 ± 1.033
4.558ArgAsp: 4.558 ± 2.083
3.646ArgGlu: 3.646 ± 1.763
2.735ArgPhe: 2.735 ± 0.903
2.735ArgGly: 2.735 ± 0.898
4.558ArgHis: 4.558 ± 2.195
5.469ArgIle: 5.469 ± 1.617
2.735ArgLys: 2.735 ± 1.665
4.558ArgLeu: 4.558 ± 1.787
0.912ArgMet: 0.912 ± 0.699
1.823ArgAsn: 1.823 ± 1.307
8.204ArgPro: 8.204 ± 1.637
0.912ArgGln: 0.912 ± 1.003
9.116ArgArg: 9.116 ± 5.114
3.646ArgSer: 3.646 ± 2.28
5.469ArgThr: 5.469 ± 1.891
3.646ArgVal: 3.646 ± 2.285
0.0ArgTrp: 0.0 ± 0.0
1.823ArgTyr: 1.823 ± 1.21
0.0ArgXaa: 0.0 ± 0.0
Ser
4.558SerAla: 4.558 ± 2.902
0.0SerCys: 0.0 ± 0.0
3.646SerAsp: 3.646 ± 1.613
3.646SerGlu: 3.646 ± 1.936
1.823SerPhe: 1.823 ± 1.221
3.646SerGly: 3.646 ± 1.851
2.735SerHis: 2.735 ± 1.437
3.646SerIle: 3.646 ± 1.35
4.558SerLys: 4.558 ± 1.71
2.735SerLeu: 2.735 ± 1.28
1.823SerMet: 1.823 ± 1.247
3.646SerAsn: 3.646 ± 1.369
7.293SerPro: 7.293 ± 2.31
3.646SerGln: 3.646 ± 1.592
4.558SerArg: 4.558 ± 1.863
10.027SerSer: 10.027 ± 5.526
6.381SerThr: 6.381 ± 3.115
3.646SerVal: 3.646 ± 1.924
0.0SerTrp: 0.0 ± 0.0
3.646SerTyr: 3.646 ± 1.103
0.0SerXaa: 0.0 ± 0.0
Thr
4.558ThrAla: 4.558 ± 1.253
1.823ThrCys: 1.823 ± 1.247
0.912ThrAsp: 0.912 ± 1.003
2.735ThrGlu: 2.735 ± 1.394
0.912ThrPhe: 0.912 ± 1.003
3.646ThrGly: 3.646 ± 0.965
2.735ThrHis: 2.735 ± 1.7
4.558ThrIle: 4.558 ± 2.009
2.735ThrLys: 2.735 ± 1.138
5.469ThrLeu: 5.469 ± 2.509
0.912ThrMet: 0.912 ± 0.676
6.381ThrAsn: 6.381 ± 2.074
6.381ThrPro: 6.381 ± 2.19
1.823ThrGln: 1.823 ± 1.288
2.735ThrArg: 2.735 ± 1.394
5.469ThrSer: 5.469 ± 1.797
0.912ThrThr: 0.912 ± 0.844
5.469ThrVal: 5.469 ± 3.003
2.735ThrTrp: 2.735 ± 2.216
1.823ThrTyr: 1.823 ± 1.023
0.0ThrXaa: 0.0 ± 0.0
Val
0.0ValAla: 0.0 ± 0.0
0.912ValCys: 0.912 ± 0.676
1.823ValAsp: 1.823 ± 0.847
1.823ValGlu: 1.823 ± 2.065
3.646ValPhe: 3.646 ± 0.965
2.735ValGly: 2.735 ± 1.7
0.912ValHis: 0.912 ± 1.033
6.381ValIle: 6.381 ± 1.789
3.646ValLys: 3.646 ± 1.341
7.293ValLeu: 7.293 ± 2.513
1.823ValMet: 1.823 ± 1.399
0.0ValAsn: 0.0 ± 0.0
3.646ValPro: 3.646 ± 1.111
6.381ValGln: 6.381 ± 3.017
2.735ValArg: 2.735 ± 1.7
4.558ValSer: 4.558 ± 2.114
3.646ValThr: 3.646 ± 2.242
0.912ValVal: 0.912 ± 0.699
0.0ValTrp: 0.0 ± 0.0
4.558ValTyr: 4.558 ± 1.822
0.0ValXaa: 0.0 ± 0.0
Trp
1.823TrpAla: 1.823 ± 1.352
0.0TrpCys: 0.0 ± 0.0
1.823TrpAsp: 1.823 ± 1.496
0.0TrpGlu: 0.0 ± 0.0
0.0TrpPhe: 0.0 ± 0.0
0.912TrpGly: 0.912 ± 0.676
0.0TrpHis: 0.0 ± 0.0
0.0TrpIle: 0.0 ± 0.0
0.0TrpLys: 0.0 ± 0.0
0.0TrpLeu: 0.0 ± 0.0
0.912TrpMet: 0.912 ± 0.699
0.0TrpAsn: 0.0 ± 0.0
0.0TrpPro: 0.0 ± 0.0
0.912TrpGln: 0.912 ± 0.676
2.735TrpArg: 2.735 ± 1.018
0.0TrpSer: 0.0 ± 0.0
2.735TrpThr: 2.735 ± 2.216
0.912TrpVal: 0.912 ± 0.676
0.0TrpTrp: 0.0 ± 0.0
0.912TrpTyr: 0.912 ± 0.676
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.735TyrAla: 2.735 ± 1.18
0.912TyrCys: 0.912 ± 1.033
2.735TyrAsp: 2.735 ± 2.098
0.912TyrGlu: 0.912 ± 0.699
3.646TyrPhe: 3.646 ± 0.965
0.912TyrGly: 0.912 ± 0.676
0.0TyrHis: 0.0 ± 0.0
1.823TyrIle: 1.823 ± 1.352
0.912TyrLys: 0.912 ± 0.676
6.381TyrLeu: 6.381 ± 0.921
1.823TyrMet: 1.823 ± 1.167
1.823TyrAsn: 1.823 ± 0.66
1.823TyrPro: 1.823 ± 1.221
1.823TyrGln: 1.823 ± 0.66
2.735TyrArg: 2.735 ± 2.098
2.735TyrSer: 2.735 ± 1.393
0.912TyrThr: 0.912 ± 1.096
4.558TyrVal: 4.558 ± 1.398
0.0TyrTrp: 0.0 ± 0.0
0.912TyrTyr: 0.912 ± 0.844
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 6 proteins (1098 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski