Amino acid dipepetide frequency for Salipaludibacillus neizhouensis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	4.676AlaAla: 4.676 ± 0.07	0.568AlaCys: 0.568 ± 0.02	3.106AlaAsp: 3.106 ± 0.05	4.424AlaGlu: 4.424 ± 0.068	3.146AlaPhe: 3.146 ± 0.048	4.811AlaGly: 4.811 ± 0.069	1.194AlaHis: 1.194 ± 0.03	5.52AlaIle: 5.52 ± 0.072	4.141AlaLys: 4.141 ± 0.063	6.462AlaLeu: 6.462 ± 0.079	1.877AlaMet: 1.877 ± 0.042	2.767AlaAsn: 2.767 ± 0.046	1.887AlaPro: 1.887 ± 0.041	1.887AlaGln: 1.887 ± 0.037	2.448AlaArg: 2.448 ± 0.048	4.189AlaSer: 4.189 ± 0.062	3.467AlaThr: 3.467 ± 0.051	4.751AlaVal: 4.751 ± 0.061	0.622AlaTrp: 0.622 ± 0.024	2.08AlaTyr: 2.08 ± 0.042	0.0AlaXaa: 0.0 ± 0.0
Cys	0.367CysAla: 0.367 ± 0.02	0.086CysCys: 0.086 ± 0.008	0.361CysAsp: 0.361 ± 0.017	0.445CysGlu: 0.445 ± 0.018	0.279CysPhe: 0.279 ± 0.014	0.614CysGly: 0.614 ± 0.02	0.199CysHis: 0.199 ± 0.011	0.458CysIle: 0.458 ± 0.019	0.365CysLys: 0.365 ± 0.017	0.667CysLeu: 0.667 ± 0.022	0.18CysMet: 0.18 ± 0.012	0.305CysAsn: 0.305 ± 0.016	0.31CysPro: 0.31 ± 0.016	0.209CysGln: 0.209 ± 0.014	0.272CysArg: 0.272 ± 0.013	0.486CysSer: 0.486 ± 0.019	0.353CysThr: 0.353 ± 0.015	0.421CysVal: 0.421 ± 0.016	0.066CysTrp: 0.066 ± 0.007	0.238CysTyr: 0.238 ± 0.011	0.0CysXaa: 0.0 ± 0.0
Asp	3.168AspAla: 3.168 ± 0.045	0.332AspCys: 0.332 ± 0.015	2.888AspAsp: 2.888 ± 0.046	4.503AspGlu: 4.503 ± 0.061	2.485AspPhe: 2.485 ± 0.039	3.584AspGly: 3.584 ± 0.066	1.323AspHis: 1.323 ± 0.031	4.325AspIle: 4.325 ± 0.061	3.161AspLys: 3.161 ± 0.05	5.19AspLeu: 5.19 ± 0.062	1.488AspMet: 1.488 ± 0.028	2.209AspAsn: 2.209 ± 0.041	2.113AspPro: 2.113 ± 0.038	2.131AspGln: 2.131 ± 0.041	2.298AspArg: 2.298 ± 0.043	3.048AspSer: 3.048 ± 0.051	2.659AspThr: 2.659 ± 0.05	3.882AspVal: 3.882 ± 0.059	0.718AspTrp: 0.718 ± 0.02	2.257AspTyr: 2.257 ± 0.043	0.0AspXaa: 0.0 ± 0.0
Glu	5.252GluAla: 5.252 ± 0.073	0.409GluCys: 0.409 ± 0.019	4.418GluAsp: 4.418 ± 0.062	8.011GluGlu: 8.011 ± 0.103	2.695GluPhe: 2.695 ± 0.047	4.706GluGly: 4.706 ± 0.061	1.43GluHis: 1.43 ± 0.036	5.777GluIle: 5.777 ± 0.063	6.444GluLys: 6.444 ± 0.085	7.288GluLeu: 7.288 ± 0.077	2.405GluMet: 2.405 ± 0.048	4.238GluAsn: 4.238 ± 0.061	1.969GluPro: 1.969 ± 0.04	3.026GluGln: 3.026 ± 0.055	3.316GluArg: 3.316 ± 0.057	4.219GluSer: 4.219 ± 0.056	4.243GluThr: 4.243 ± 0.059	5.4GluVal: 5.4 ± 0.066	0.946GluTrp: 0.946 ± 0.026	2.37GluTyr: 2.37 ± 0.042	0.0GluXaa: 0.0 ± 0.0
Phe	2.869PheAla: 2.869 ± 0.045	0.321PheCys: 0.321 ± 0.015	2.491PheAsp: 2.491 ± 0.04	3.003PheGlu: 3.003 ± 0.054	2.495PhePhe: 2.495 ± 0.053	3.224PheGly: 3.224 ± 0.048	1.071PheHis: 1.071 ± 0.028	4.106PheIle: 4.106 ± 0.067	2.476PheLys: 2.476 ± 0.044	4.738PheLeu: 4.738 ± 0.065	1.223PheMet: 1.223 ± 0.032	2.017PheAsn: 2.017 ± 0.042	1.786PhePro: 1.786 ± 0.036	1.745PheGln: 1.745 ± 0.032	1.628PheArg: 1.628 ± 0.037	3.464PheSer: 3.464 ± 0.059	2.699PheThr: 2.699 ± 0.039	2.999PheVal: 2.999 ± 0.053	0.53PheTrp: 0.53 ± 0.021	1.758PheTyr: 1.758 ± 0.037	0.0PheXaa: 0.0 ± 0.0
Gly	4.718GlyAla: 4.718 ± 0.079	0.553GlyCys: 0.553 ± 0.021	3.383GlyAsp: 3.383 ± 0.057	4.842GlyGlu: 4.842 ± 0.07	3.506GlyPhe: 3.506 ± 0.055	4.787GlyGly: 4.787 ± 0.07	1.322GlyHis: 1.322 ± 0.035	5.885GlyIle: 5.885 ± 0.066	4.69GlyLys: 4.69 ± 0.06	6.421GlyLeu: 6.421 ± 0.078	2.135GlyMet: 2.135 ± 0.04	2.924GlyAsn: 2.924 ± 0.056	1.714GlyPro: 1.714 ± 0.038	2.028GlyGln: 2.028 ± 0.04	2.491GlyArg: 2.491 ± 0.045	4.14GlySer: 4.14 ± 0.058	3.913GlyThr: 3.913 ± 0.06	5.079GlyVal: 5.079 ± 0.061	0.831GlyTrp: 0.831 ± 0.024	2.683GlyTyr: 2.683 ± 0.048	0.0GlyXaa: 0.0 ± 0.0
His	1.258HisAla: 1.258 ± 0.033	0.185HisCys: 0.185 ± 0.011	1.078HisAsp: 1.078 ± 0.03	1.511HisGlu: 1.511 ± 0.033	1.125HisPhe: 1.125 ± 0.031	1.466HisGly: 1.466 ± 0.031	0.692HisHis: 0.692 ± 0.024	1.527HisIle: 1.527 ± 0.036	0.997HisLys: 0.997 ± 0.028	2.192HisLeu: 2.192 ± 0.041	0.52HisMet: 0.52 ± 0.019	0.791HisAsn: 0.791 ± 0.023	1.035HisPro: 1.035 ± 0.029	0.907HisGln: 0.907 ± 0.027	0.906HisArg: 0.906 ± 0.028	1.36HisSer: 1.36 ± 0.031	1.039HisThr: 1.039 ± 0.026	1.466HisVal: 1.466 ± 0.029	0.274HisTrp: 0.274 ± 0.014	0.88HisTyr: 0.88 ± 0.027	0.0HisXaa: 0.0 ± 0.0
Ile	5.498IleAla: 5.498 ± 0.074	0.588IleCys: 0.588 ± 0.02	4.659IleAsp: 4.659 ± 0.053	5.79IleGlu: 5.79 ± 0.07	3.54IlePhe: 3.54 ± 0.059	6.057IleGly: 6.057 ± 0.081	1.736IleHis: 1.736 ± 0.034	6.251IleIle: 6.251 ± 0.085	4.486IleLys: 4.486 ± 0.072	7.295IleLeu: 7.295 ± 0.086	1.85IleMet: 1.85 ± 0.034	3.562IleAsn: 3.562 ± 0.055	3.385IlePro: 3.385 ± 0.053	2.865IleGln: 2.865 ± 0.056	3.031IleArg: 3.031 ± 0.047	5.334IleSer: 5.334 ± 0.061	4.43IleThr: 4.43 ± 0.059	5.503IleVal: 5.503 ± 0.072	0.701IleTrp: 0.701 ± 0.024	2.576IleTyr: 2.576 ± 0.043	0.0IleXaa: 0.0 ± 0.0
Lys	3.919LysAla: 3.919 ± 0.055	0.286LysCys: 0.286 ± 0.015	3.924LysAsp: 3.924 ± 0.053	6.731LysGlu: 6.731 ± 0.076	1.923LysPhe: 1.923 ± 0.039	4.217LysGly: 4.217 ± 0.061	1.409LysHis: 1.409 ± 0.032	4.491LysIle: 4.491 ± 0.06	5.858LysLys: 5.858 ± 0.083	5.633LysLeu: 5.633 ± 0.078	2.0LysMet: 2.0 ± 0.036	3.446LysAsn: 3.446 ± 0.052	1.976LysPro: 1.976 ± 0.037	2.869LysGln: 2.869 ± 0.058	3.057LysArg: 3.057 ± 0.047	3.618LysSer: 3.618 ± 0.055	3.509LysThr: 3.509 ± 0.051	4.431LysVal: 4.431 ± 0.06	0.773LysTrp: 0.773 ± 0.023	2.131LysTyr: 2.131 ± 0.043	0.0LysXaa: 0.0 ± 0.0
Leu	6.752LeuAla: 6.752 ± 0.072	0.655LeuCys: 0.655 ± 0.023	5.11LeuAsp: 5.11 ± 0.066	6.956LeuGlu: 6.956 ± 0.089	5.007LeuPhe: 5.007 ± 0.082	6.311LeuGly: 6.311 ± 0.073	1.952LeuHis: 1.952 ± 0.037	7.39LeuIle: 7.39 ± 0.088	6.292LeuLys: 6.292 ± 0.074	9.79LeuLeu: 9.79 ± 0.109	2.583LeuMet: 2.583 ± 0.044	4.354LeuAsn: 4.354 ± 0.059	3.807LeuPro: 3.807 ± 0.057	3.324LeuGln: 3.324 ± 0.053	3.557LeuArg: 3.557 ± 0.05	6.901LeuSer: 6.901 ± 0.063	5.603LeuThr: 5.603 ± 0.06	6.265LeuVal: 6.265 ± 0.076	0.848LeuTrp: 0.848 ± 0.025	3.108LeuTyr: 3.108 ± 0.053	0.0LeuXaa: 0.0 ± 0.0
Met	1.86MetAla: 1.86 ± 0.038	0.148MetCys: 0.148 ± 0.01	1.571MetAsp: 1.571 ± 0.035	2.168MetGlu: 2.168 ± 0.04	1.131MetPhe: 1.131 ± 0.031	1.756MetGly: 1.756 ± 0.037	0.439MetHis: 0.439 ± 0.019	2.34MetIle: 2.34 ± 0.042	2.497MetLys: 2.497 ± 0.042	2.481MetLeu: 2.481 ± 0.043	0.892MetMet: 0.892 ± 0.029	1.658MetAsn: 1.658 ± 0.039	0.98MetPro: 0.98 ± 0.026	0.889MetGln: 0.889 ± 0.027	1.035MetArg: 1.035 ± 0.027	1.838MetSer: 1.838 ± 0.04	1.731MetThr: 1.731 ± 0.037	1.852MetVal: 1.852 ± 0.037	0.214MetTrp: 0.214 ± 0.011	0.744MetTyr: 0.744 ± 0.023	0.0MetXaa: 0.0 ± 0.0
Asn	2.513AsnAla: 2.513 ± 0.045	0.285AsnCys: 0.285 ± 0.014	2.652AsnAsp: 2.652 ± 0.047	3.978AsnGlu: 3.978 ± 0.058	1.793AsnPhe: 1.793 ± 0.032	3.291AsnGly: 3.291 ± 0.056	1.163AsnHis: 1.163 ± 0.03	3.565AsnIle: 3.565 ± 0.061	3.082AsnLys: 3.082 ± 0.052	3.994AsnLeu: 3.994 ± 0.057	1.262AsnMet: 1.262 ± 0.028	2.474AsnAsn: 2.474 ± 0.062	2.068AsnPro: 2.068 ± 0.039	1.984AsnGln: 1.984 ± 0.041	2.058AsnArg: 2.058 ± 0.042	2.704AsnSer: 2.704 ± 0.049	2.364AsnThr: 2.364 ± 0.046	3.108AsnVal: 3.108 ± 0.049	0.595AsnTrp: 0.595 ± 0.021	1.79AsnTyr: 1.79 ± 0.04	0.0AsnXaa: 0.0 ± 0.0
Pro	2.051ProAla: 2.051 ± 0.038	0.195ProCys: 0.195 ± 0.012	1.985ProAsp: 1.985 ± 0.043	3.056ProGlu: 3.056 ± 0.051	2.039ProPhe: 2.039 ± 0.04	2.193ProGly: 2.193 ± 0.044	0.791ProHis: 0.791 ± 0.025	2.787ProIle: 2.787 ± 0.052	1.974ProLys: 1.974 ± 0.037	3.446ProLeu: 3.446 ± 0.048	0.9ProMet: 0.9 ± 0.029	1.647ProAsn: 1.647 ± 0.036	0.991ProPro: 0.991 ± 0.028	1.072ProGln: 1.072 ± 0.028	1.068ProArg: 1.068 ± 0.028	2.392ProSer: 2.392 ± 0.044	1.894ProThr: 1.894 ± 0.043	2.72ProVal: 2.72 ± 0.047	0.423ProTrp: 0.423 ± 0.019	1.353ProTyr: 1.353 ± 0.03	0.0ProXaa: 0.0 ± 0.0
Gln	2.434GlnAla: 2.434 ± 0.041	0.188GlnCys: 0.188 ± 0.012	1.678GlnAsp: 1.678 ± 0.036	2.99GlnGlu: 2.99 ± 0.052	1.517GlnPhe: 1.517 ± 0.036	2.264GlnGly: 2.264 ± 0.032	0.765GlnHis: 0.765 ± 0.025	2.439GlnIle: 2.439 ± 0.045	2.416GlnLys: 2.416 ± 0.049	3.895GlnLeu: 3.895 ± 0.056	1.06GlnMet: 1.06 ± 0.029	1.474GlnAsn: 1.474 ± 0.032	1.101GlnPro: 1.101 ± 0.033	1.654GlnGln: 1.654 ± 0.054	1.456GlnArg: 1.456 ± 0.036	2.3GlnSer: 2.3 ± 0.042	1.976GlnThr: 1.976 ± 0.04	2.399GlnVal: 2.399 ± 0.044	0.457GlnTrp: 0.457 ± 0.016	1.158GlnTyr: 1.158 ± 0.029	0.0GlnXaa: 0.0 ± 0.0
Arg	2.132ArgAla: 2.132 ± 0.033	0.235ArgCys: 0.235 ± 0.012	2.04ArgAsp: 2.04 ± 0.036	3.183ArgGlu: 3.183 ± 0.054	1.852ArgPhe: 1.852 ± 0.037	2.395ArgGly: 2.395 ± 0.045	0.805ArgHis: 0.805 ± 0.024	3.071ArgIle: 3.071 ± 0.047	3.06ArgLys: 3.06 ± 0.052	3.738ArgLeu: 3.738 ± 0.057	1.266ArgMet: 1.266 ± 0.026	1.933ArgAsn: 1.933 ± 0.043	1.26ArgPro: 1.26 ± 0.028	1.421ArgGln: 1.421 ± 0.038	1.778ArgArg: 1.778 ± 0.039	2.381ArgSer: 2.381 ± 0.038	2.059ArgThr: 2.059 ± 0.039	2.6ArgVal: 2.6 ± 0.04	0.465ArgTrp: 0.465 ± 0.018	1.522ArgTyr: 1.522 ± 0.038	0.0ArgXaa: 0.0 ± 0.0
Ser	3.766SerAla: 3.766 ± 0.058	0.407SerCys: 0.407 ± 0.016	3.189SerAsp: 3.189 ± 0.058	4.726SerGlu: 4.726 ± 0.063	3.571SerPhe: 3.571 ± 0.051	4.507SerGly: 4.507 ± 0.066	1.35SerHis: 1.35 ± 0.032	5.295SerIle: 5.295 ± 0.069	3.97SerLys: 3.97 ± 0.057	6.608SerLeu: 6.608 ± 0.072	1.937SerMet: 1.937 ± 0.034	3.021SerAsn: 3.021 ± 0.053	2.168SerPro: 2.168 ± 0.04	2.097SerGln: 2.097 ± 0.043	2.393SerArg: 2.393 ± 0.041	4.483SerSer: 4.483 ± 0.063	3.383SerThr: 3.383 ± 0.05	4.418SerVal: 4.418 ± 0.064	0.714SerTrp: 0.714 ± 0.024	2.416SerTyr: 2.416 ± 0.04	0.0SerXaa: 0.0 ± 0.0
Thr	3.597ThrAla: 3.597 ± 0.058	0.359ThrCys: 0.359 ± 0.017	2.876ThrAsp: 2.876 ± 0.046	3.878ThrGlu: 3.878 ± 0.056	2.857ThrPhe: 2.857 ± 0.052	4.152ThrGly: 4.152 ± 0.055	1.073ThrHis: 1.073 ± 0.026	4.547ThrIle: 4.547 ± 0.054	3.255ThrLys: 3.255 ± 0.048	5.358ThrLeu: 5.358 ± 0.075	1.476ThrMet: 1.476 ± 0.037	2.648ThrAsn: 2.648 ± 0.045	2.211ThrPro: 2.211 ± 0.039	1.488ThrGln: 1.488 ± 0.03	1.86ThrArg: 1.86 ± 0.037	3.593ThrSer: 3.593 ± 0.054	2.969ThrThr: 2.969 ± 0.053	4.09ThrVal: 4.09 ± 0.058	0.623ThrTrp: 0.623 ± 0.02	1.914ThrTyr: 1.914 ± 0.037	0.0ThrXaa: 0.0 ± 0.0
Val	4.631ValAla: 4.631 ± 0.069	0.517ValCys: 0.517 ± 0.02	3.829ValAsp: 3.829 ± 0.055	5.011ValGlu: 5.011 ± 0.066	3.233ValPhe: 3.233 ± 0.051	4.489ValGly: 4.489 ± 0.07	1.348ValHis: 1.348 ± 0.031	5.937ValIle: 5.937 ± 0.076	4.296ValLys: 4.296 ± 0.065	6.625ValLeu: 6.625 ± 0.075	1.887ValMet: 1.887 ± 0.037	3.221ValAsn: 3.221 ± 0.052	2.519ValPro: 2.519 ± 0.043	2.201ValGln: 2.201 ± 0.04	2.495ValArg: 2.495 ± 0.042	4.918ValSer: 4.918 ± 0.064	4.206ValThr: 4.206 ± 0.058	4.904ValVal: 4.904 ± 0.065	0.633ValTrp: 0.633 ± 0.022	2.241ValTyr: 2.241 ± 0.044	0.0ValXaa: 0.0 ± 0.0
Trp	0.644TrpAla: 0.644 ± 0.022	0.084TrpCys: 0.084 ± 0.007	0.593TrpAsp: 0.593 ± 0.025	0.797TrpGlu: 0.797 ± 0.024	0.54TrpPhe: 0.54 ± 0.018	0.749TrpGly: 0.749 ± 0.027	0.238TrpHis: 0.238 ± 0.015	0.935TrpIle: 0.935 ± 0.029	0.746TrpLys: 0.746 ± 0.024	1.183TrpLeu: 1.183 ± 0.027	0.396TrpMet: 0.396 ± 0.017	0.535TrpAsn: 0.535 ± 0.02	0.288TrpPro: 0.288 ± 0.016	0.4TrpGln: 0.4 ± 0.018	0.443TrpArg: 0.443 ± 0.017	0.715TrpSer: 0.715 ± 0.023	0.553TrpThr: 0.553 ± 0.023	0.657TrpVal: 0.657 ± 0.023	0.151TrpTrp: 0.151 ± 0.01	0.349TrpTyr: 0.349 ± 0.018	0.0TrpXaa: 0.0 ± 0.0
Tyr	1.919TyrAla: 1.919 ± 0.038	0.28TyrCys: 0.28 ± 0.014	1.932TyrAsp: 1.932 ± 0.041	2.56TyrGlu: 2.56 ± 0.05	1.908TyrPhe: 1.908 ± 0.042	2.472TyrGly: 2.472 ± 0.045	0.908TyrHis: 0.908 ± 0.026	2.49TyrIle: 2.49 ± 0.045	1.993TyrLys: 1.993 ± 0.039	3.56TyrLeu: 3.56 ± 0.053	0.887TyrMet: 0.887 ± 0.02	1.503TyrAsn: 1.503 ± 0.036	1.408TyrPro: 1.408 ± 0.027	1.425TyrGln: 1.425 ± 0.028	1.604TyrArg: 1.604 ± 0.035	2.336TyrSer: 2.336 ± 0.04	1.775TyrThr: 1.775 ± 0.033	2.198TyrVal: 2.198 ± 0.046	0.412TyrTrp: 0.412 ± 0.02	1.482TyrTyr: 1.482 ± 0.035	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4767 proteins (1414254 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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