Amino acid dipepetide frequency for Metarhizium acridum (strain CQMa 102)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	9.808AlaAla: 9.808 ± 0.063	1.118AlaCys: 1.118 ± 0.017	4.537AlaAsp: 4.537 ± 0.029	5.16AlaGlu: 5.16 ± 0.046	3.151AlaPhe: 3.151 ± 0.025	6.094AlaGly: 6.094 ± 0.037	1.854AlaHis: 1.854 ± 0.019	4.232AlaIle: 4.232 ± 0.035	4.341AlaLys: 4.341 ± 0.041	7.794AlaLeu: 7.794 ± 0.052	2.095AlaMet: 2.095 ± 0.025	3.121AlaAsn: 3.121 ± 0.027	4.672AlaPro: 4.672 ± 0.046	3.475AlaGln: 3.475 ± 0.028	5.191AlaArg: 5.191 ± 0.034	7.511AlaSer: 7.511 ± 0.046	5.365AlaThr: 5.365 ± 0.039	5.84AlaVal: 5.84 ± 0.045	1.224AlaTrp: 1.224 ± 0.017	2.143AlaTyr: 2.143 ± 0.02	0.0AlaXaa: 0.0 ± 0.0
Cys	1.001CysAla: 1.001 ± 0.018	0.255CysCys: 0.255 ± 0.009	0.688CysAsp: 0.688 ± 0.013	0.61CysGlu: 0.61 ± 0.013	0.548CysPhe: 0.548 ± 0.011	0.967CysGly: 0.967 ± 0.017	0.353CysHis: 0.353 ± 0.009	0.686CysIle: 0.686 ± 0.012	0.531CysLys: 0.531 ± 0.012	1.284CysLeu: 1.284 ± 0.017	0.272CysMet: 0.272 ± 0.008	0.465CysAsn: 0.465 ± 0.009	0.713CysPro: 0.713 ± 0.014	0.49CysGln: 0.49 ± 0.01	0.808CysArg: 0.808 ± 0.015	0.955CysSer: 0.955 ± 0.016	0.696CysThr: 0.696 ± 0.014	0.811CysVal: 0.811 ± 0.015	0.205CysTrp: 0.205 ± 0.007	0.341CysTyr: 0.341 ± 0.009	0.0CysXaa: 0.0 ± 0.0
Asp	5.116AspAla: 5.116 ± 0.032	0.668AspCys: 0.668 ± 0.011	4.581AspAsp: 4.581 ± 0.06	4.629AspGlu: 4.629 ± 0.052	2.23AspPhe: 2.23 ± 0.021	4.452AspGly: 4.452 ± 0.039	1.25AspHis: 1.25 ± 0.016	3.043AspIle: 3.043 ± 0.028	2.684AspLys: 2.684 ± 0.027	4.897AspLeu: 4.897 ± 0.036	1.449AspMet: 1.449 ± 0.017	1.96AspAsn: 1.96 ± 0.021	3.098AspPro: 3.098 ± 0.031	1.882AspGln: 1.882 ± 0.022	3.073AspArg: 3.073 ± 0.03	4.18AspSer: 4.18 ± 0.032	2.908AspThr: 2.908 ± 0.025	3.877AspVal: 3.877 ± 0.028	0.903AspTrp: 0.903 ± 0.013	1.533AspTyr: 1.533 ± 0.018	0.0AspXaa: 0.0 ± 0.0
Glu	5.6GluAla: 5.6 ± 0.046	0.636GluCys: 0.636 ± 0.013	4.066GluAsp: 4.066 ± 0.04	5.025GluGlu: 5.025 ± 0.057	1.94GluPhe: 1.94 ± 0.02	3.473GluGly: 3.473 ± 0.031	1.36GluHis: 1.36 ± 0.019	2.789GluIle: 2.789 ± 0.025	3.551GluLys: 3.551 ± 0.036	5.215GluLeu: 5.215 ± 0.05	1.457GluMet: 1.457 ± 0.017	2.176GluAsn: 2.176 ± 0.022	2.896GluPro: 2.896 ± 0.034	2.478GluGln: 2.478 ± 0.023	3.844GluArg: 3.844 ± 0.046	4.233GluSer: 4.233 ± 0.033	3.391GluThr: 3.391 ± 0.032	3.378GluVal: 3.378 ± 0.031	0.845GluTrp: 0.845 ± 0.012	1.625GluTyr: 1.625 ± 0.019	0.0GluXaa: 0.0 ± 0.0
Phe	3.055PheAla: 3.055 ± 0.026	0.554PheCys: 0.554 ± 0.01	2.292PheAsp: 2.292 ± 0.024	2.061PheGlu: 2.061 ± 0.024	1.571PhePhe: 1.571 ± 0.022	2.837PheGly: 2.837 ± 0.035	0.894PheHis: 0.894 ± 0.016	1.736PheIle: 1.736 ± 0.018	1.564PheLys: 1.564 ± 0.018	3.3PheLeu: 3.3 ± 0.029	0.8PheMet: 0.8 ± 0.013	1.418PheAsn: 1.418 ± 0.018	1.895PhePro: 1.895 ± 0.021	1.37PheGln: 1.37 ± 0.02	1.95PheArg: 1.95 ± 0.02	2.865PheSer: 2.865 ± 0.029	2.044PheThr: 2.044 ± 0.021	2.437PheVal: 2.437 ± 0.024	0.634PheTrp: 0.634 ± 0.012	1.043PheTyr: 1.043 ± 0.015	0.0PheXaa: 0.0 ± 0.0
Gly	5.546GlyAla: 5.546 ± 0.043	0.889GlyCys: 0.889 ± 0.016	3.886GlyAsp: 3.886 ± 0.037	3.704GlyGlu: 3.704 ± 0.031	2.735GlyPhe: 2.735 ± 0.027	5.885GlyGly: 5.885 ± 0.065	1.845GlyHis: 1.845 ± 0.022	3.532GlyIle: 3.532 ± 0.024	3.564GlyLys: 3.564 ± 0.03	6.089GlyLeu: 6.089 ± 0.045	1.62GlyMet: 1.62 ± 0.019	2.651GlyAsn: 2.651 ± 0.031	3.555GlyPro: 3.555 ± 0.039	2.732GlyGln: 2.732 ± 0.026	4.379GlyArg: 4.379 ± 0.041	5.885GlySer: 5.885 ± 0.048	3.999GlyThr: 3.999 ± 0.033	4.418GlyVal: 4.418 ± 0.041	1.177GlyTrp: 1.177 ± 0.02	2.065GlyTyr: 2.065 ± 0.023	0.0GlyXaa: 0.0 ± 0.0
His	1.913HisAla: 1.913 ± 0.021	0.35HisCys: 0.35 ± 0.01	1.435HisAsp: 1.435 ± 0.019	1.316HisGlu: 1.316 ± 0.017	0.883HisPhe: 0.883 ± 0.015	1.899HisGly: 1.899 ± 0.024	0.905HisHis: 0.905 ± 0.02	1.188HisIle: 1.188 ± 0.016	0.96HisLys: 0.96 ± 0.016	2.238HisLeu: 2.238 ± 0.022	0.539HisMet: 0.539 ± 0.011	0.844HisAsn: 0.844 ± 0.014	1.587HisPro: 1.587 ± 0.018	1.064HisGln: 1.064 ± 0.015	1.578HisArg: 1.578 ± 0.021	1.771HisSer: 1.771 ± 0.021	1.225HisThr: 1.225 ± 0.016	1.635HisVal: 1.635 ± 0.023	0.344HisTrp: 0.344 ± 0.008	0.661HisTyr: 0.661 ± 0.012	0.0HisXaa: 0.0 ± 0.0
Ile	4.027IleAla: 4.027 ± 0.032	0.746IleCys: 0.746 ± 0.014	2.761IleAsp: 2.761 ± 0.025	2.694IleGlu: 2.694 ± 0.026	1.85IlePhe: 1.85 ± 0.021	3.142IleGly: 3.142 ± 0.026	1.184IleHis: 1.184 ± 0.015	2.347IleIle: 2.347 ± 0.028	2.177IleLys: 2.177 ± 0.022	4.408IleLeu: 4.408 ± 0.041	1.026IleMet: 1.026 ± 0.014	1.751IleAsn: 1.751 ± 0.021	2.91IlePro: 2.91 ± 0.025	1.856IleGln: 1.856 ± 0.021	2.799IleArg: 2.799 ± 0.026	3.706IleSer: 3.706 ± 0.027	2.667IleThr: 2.667 ± 0.022	3.085IleVal: 3.085 ± 0.03	0.712IleTrp: 0.712 ± 0.014	1.313IleTyr: 1.313 ± 0.017	0.0IleXaa: 0.0 ± 0.0
Lys	4.418LysAla: 4.418 ± 0.039	0.532LysCys: 0.532 ± 0.012	2.908LysAsp: 2.908 ± 0.027	3.207LysGlu: 3.207 ± 0.033	1.514LysPhe: 1.514 ± 0.018	3.02LysGly: 3.02 ± 0.029	1.161LysHis: 1.161 ± 0.016	2.19LysIle: 2.19 ± 0.024	3.33LysLys: 3.33 ± 0.05	4.277LysLeu: 4.277 ± 0.033	1.079LysMet: 1.079 ± 0.016	1.919LysAsn: 1.919 ± 0.136	2.825LysPro: 2.825 ± 0.036	1.913LysGln: 1.913 ± 0.022	3.369LysArg: 3.369 ± 0.03	3.602LysSer: 3.602 ± 0.035	2.953LysThr: 2.953 ± 0.027	2.788LysVal: 2.788 ± 0.026	0.68LysTrp: 0.68 ± 0.013	1.383LysTyr: 1.383 ± 0.019	0.0LysXaa: 0.0 ± 0.0
Leu	8.103LeuAla: 8.103 ± 0.055	1.255LeuCys: 1.255 ± 0.019	5.293LeuAsp: 5.293 ± 0.036	5.303LeuGlu: 5.303 ± 0.043	3.205LeuPhe: 3.205 ± 0.031	6.13LeuGly: 6.13 ± 0.043	2.19LeuHis: 2.19 ± 0.024	3.75LeuIle: 3.75 ± 0.029	4.124LeuLys: 4.124 ± 0.038	8.214LeuLeu: 8.214 ± 0.062	1.789LeuMet: 1.789 ± 0.019	3.056LeuAsn: 3.056 ± 0.026	5.358LeuPro: 5.358 ± 0.036	3.789LeuGln: 3.789 ± 0.036	5.859LeuArg: 5.859 ± 0.039	7.088LeuSer: 7.088 ± 0.047	4.66LeuThr: 4.66 ± 0.033	5.654LeuVal: 5.654 ± 0.041	1.213LeuTrp: 1.213 ± 0.018	2.259LeuTyr: 2.259 ± 0.024	0.0LeuXaa: 0.0 ± 0.0
Met	2.38MetAla: 2.38 ± 0.022	0.25MetCys: 0.25 ± 0.007	1.327MetAsp: 1.327 ± 0.017	1.3MetGlu: 1.3 ± 0.017	0.737MetPhe: 0.737 ± 0.012	1.524MetGly: 1.524 ± 0.019	0.5MetHis: 0.5 ± 0.01	0.929MetIle: 0.929 ± 0.017	1.06MetLys: 1.06 ± 0.014	1.942MetLeu: 1.942 ± 0.024	0.597MetMet: 0.597 ± 0.013	0.79MetAsn: 0.79 ± 0.013	1.356MetPro: 1.356 ± 0.018	0.883MetGln: 0.883 ± 0.015	1.326MetArg: 1.326 ± 0.017	1.913MetSer: 1.913 ± 0.023	1.36MetThr: 1.36 ± 0.017	1.368MetVal: 1.368 ± 0.016	0.27MetTrp: 0.27 ± 0.008	0.552MetTyr: 0.552 ± 0.01	0.0MetXaa: 0.0 ± 0.0
Asn	3.098AsnAla: 3.098 ± 0.029	0.472AsnCys: 0.472 ± 0.009	2.014AsnAsp: 2.014 ± 0.025	1.981AsnGlu: 1.981 ± 0.022	1.371AsnPhe: 1.371 ± 0.018	3.044AsnGly: 3.044 ± 0.033	0.866AsnHis: 0.866 ± 0.015	1.981AsnIle: 1.981 ± 0.018	1.669AsnLys: 1.669 ± 0.021	3.204AsnLeu: 3.204 ± 0.026	0.915AsnMet: 0.915 ± 0.014	1.478AsnAsn: 1.478 ± 0.024	2.469AsnPro: 2.469 ± 0.133	1.343AsnGln: 1.343 ± 0.019	1.984AsnArg: 1.984 ± 0.023	2.687AsnSer: 2.687 ± 0.025	2.134AsnThr: 2.134 ± 0.02	2.329AsnVal: 2.329 ± 0.025	0.554AsnTrp: 0.554 ± 0.012	1.008AsnTyr: 1.008 ± 0.016	0.0AsnXaa: 0.0 ± 0.0
Pro	5.248ProAla: 5.248 ± 0.044	0.588ProCys: 0.588 ± 0.012	3.257ProAsp: 3.257 ± 0.024	3.736ProGlu: 3.736 ± 0.038	2.013ProPhe: 2.013 ± 0.023	4.196ProGly: 4.196 ± 0.04	1.317ProHis: 1.317 ± 0.019	2.394ProIle: 2.394 ± 0.025	2.844ProLys: 2.844 ± 0.137	4.637ProLeu: 4.637 ± 0.036	1.096ProMet: 1.096 ± 0.014	2.168ProAsn: 2.168 ± 0.021	5.127ProPro: 5.127 ± 0.07	2.413ProGln: 2.413 ± 0.029	3.55ProArg: 3.55 ± 0.033	5.823ProSer: 5.823 ± 0.051	3.756ProThr: 3.756 ± 0.04	3.715ProVal: 3.715 ± 0.036	0.785ProTrp: 0.785 ± 0.013	1.422ProTyr: 1.422 ± 0.02	0.0ProXaa: 0.0 ± 0.0
Gln	3.55GlnAla: 3.55 ± 0.032	0.444GlnCys: 0.444 ± 0.011	2.231GlnAsp: 2.231 ± 0.024	2.315GlnGlu: 2.315 ± 0.022	1.276GlnPhe: 1.276 ± 0.016	2.564GlnGly: 2.564 ± 0.03	1.142GlnHis: 1.142 ± 0.019	1.817GlnIle: 1.817 ± 0.02	1.976GlnLys: 1.976 ± 0.023	3.506GlnLeu: 3.506 ± 0.032	0.918GlnMet: 0.918 ± 0.015	1.533GlnAsn: 1.533 ± 0.021	2.602GlnPro: 2.602 ± 0.034	2.476GlnGln: 2.476 ± 0.058	2.681GlnArg: 2.681 ± 0.029	3.128GlnSer: 3.128 ± 0.03	2.277GlnThr: 2.277 ± 0.023	2.329GlnVal: 2.329 ± 0.023	0.548GlnTrp: 0.548 ± 0.01	1.148GlnTyr: 1.148 ± 0.016	0.0GlnXaa: 0.0 ± 0.0
Arg	4.915ArgAla: 4.915 ± 0.037	0.743ArgCys: 0.743 ± 0.015	3.64ArgAsp: 3.64 ± 0.05	3.79ArgGlu: 3.79 ± 0.033	2.153ArgPhe: 2.153 ± 0.023	4.007ArgGly: 4.007 ± 0.039	1.721ArgHis: 1.721 ± 0.021	2.886ArgIle: 2.886 ± 0.027	3.36ArgLys: 3.36 ± 0.034	5.622ArgLeu: 5.622 ± 0.045	1.346ArgMet: 1.346 ± 0.016	2.324ArgAsn: 2.324 ± 0.022	3.684ArgPro: 3.684 ± 0.029	2.821ArgGln: 2.821 ± 0.027	5.447ArgArg: 5.447 ± 0.044	4.729ArgSer: 4.729 ± 0.046	3.23ArgThr: 3.23 ± 0.031	3.484ArgVal: 3.484 ± 0.027	0.904ArgTrp: 0.904 ± 0.013	1.584ArgTyr: 1.584 ± 0.014	0.0ArgXaa: 0.0 ± 0.0
Ser	6.681SerAla: 6.681 ± 0.047	0.943SerCys: 0.943 ± 0.013	4.203SerAsp: 4.203 ± 0.03	3.993SerGlu: 3.993 ± 0.033	2.95SerPhe: 2.95 ± 0.031	5.641SerGly: 5.641 ± 0.044	1.978SerHis: 1.978 ± 0.025	3.821SerIle: 3.821 ± 0.029	3.787SerLys: 3.787 ± 0.031	7.092SerLeu: 7.092 ± 0.044	1.786SerMet: 1.786 ± 0.02	2.926SerAsn: 2.926 ± 0.024	5.428SerPro: 5.428 ± 0.057	3.381SerGln: 3.381 ± 0.035	5.247SerArg: 5.247 ± 0.048	8.413SerSer: 8.413 ± 0.075	5.291SerThr: 5.291 ± 0.045	4.622SerVal: 4.622 ± 0.032	1.159SerTrp: 1.159 ± 0.017	1.986SerTyr: 1.986 ± 0.021	0.0SerXaa: 0.0 ± 0.0
Thr	5.251ThrAla: 5.251 ± 0.039	0.756ThrCys: 0.756 ± 0.013	2.818ThrAsp: 2.818 ± 0.022	3.025ThrGlu: 3.025 ± 0.031	2.077ThrPhe: 2.077 ± 0.022	4.187ThrGly: 4.187 ± 0.04	1.255ThrHis: 1.255 ± 0.017	2.938ThrIle: 2.938 ± 0.027	2.665ThrLys: 2.665 ± 0.026	4.998ThrLeu: 4.998 ± 0.034	1.221ThrMet: 1.221 ± 0.017	2.04ThrAsn: 2.04 ± 0.025	4.194ThrPro: 4.194 ± 0.034	2.056ThrGln: 2.056 ± 0.022	3.225ThrArg: 3.225 ± 0.028	5.133ThrSer: 5.133 ± 0.041	4.14ThrThr: 4.14 ± 0.056	3.691ThrVal: 3.691 ± 0.032	0.837ThrTrp: 0.837 ± 0.014	1.534ThrTyr: 1.534 ± 0.019	0.0ThrXaa: 0.0 ± 0.0
Val	5.694ValAla: 5.694 ± 0.04	0.873ValCys: 0.873 ± 0.016	3.91ValAsp: 3.91 ± 0.027	3.819ValGlu: 3.819 ± 0.036	2.458ValPhe: 2.458 ± 0.031	4.156ValGly: 4.156 ± 0.033	1.461ValHis: 1.461 ± 0.022	2.88ValIle: 2.88 ± 0.027	2.965ValLys: 2.965 ± 0.031	5.685ValLeu: 5.685 ± 0.039	1.354ValMet: 1.354 ± 0.016	2.272ValAsn: 2.272 ± 0.028	3.698ValPro: 3.698 ± 0.031	2.385ValGln: 2.385 ± 0.027	3.548ValArg: 3.548 ± 0.031	4.713ValSer: 4.713 ± 0.036	3.482ValThr: 3.482 ± 0.027	4.488ValVal: 4.488 ± 0.039	0.862ValTrp: 0.862 ± 0.015	1.716ValTyr: 1.716 ± 0.02	0.0ValXaa: 0.0 ± 0.0
Trp	1.201TrpAla: 1.201 ± 0.017	0.21TrpCys: 0.21 ± 0.006	0.925TrpAsp: 0.925 ± 0.015	0.841TrpGlu: 0.841 ± 0.013	0.524TrpPhe: 0.524 ± 0.011	0.917TrpGly: 0.917 ± 0.015	0.384TrpHis: 0.384 ± 0.009	0.721TrpIle: 0.721 ± 0.013	0.779TrpLys: 0.779 ± 0.012	1.367TrpLeu: 1.367 ± 0.018	0.371TrpMet: 0.371 ± 0.008	0.641TrpAsn: 0.641 ± 0.012	0.635TrpPro: 0.635 ± 0.013	0.594TrpGln: 0.594 ± 0.011	0.952TrpArg: 0.952 ± 0.015	1.023TrpSer: 1.023 ± 0.015	0.933TrpThr: 0.933 ± 0.016	0.877TrpVal: 0.877 ± 0.013	0.29TrpTrp: 0.29 ± 0.009	0.403TrpTyr: 0.403 ± 0.01	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.121TyrAla: 2.121 ± 0.021	0.398TyrCys: 0.398 ± 0.011	1.641TyrAsp: 1.641 ± 0.021	1.473TyrGlu: 1.473 ± 0.017	1.137TyrPhe: 1.137 ± 0.017	2.021TyrGly: 2.021 ± 0.024	0.714TyrHis: 0.714 ± 0.013	1.303TyrIle: 1.303 ± 0.016	1.136TyrLys: 1.136 ± 0.017	2.523TyrLeu: 2.523 ± 0.023	0.633TyrMet: 0.633 ± 0.011	1.065TyrAsn: 1.065 ± 0.016	1.383TyrPro: 1.383 ± 0.02	1.059TyrGln: 1.059 ± 0.015	1.579TyrArg: 1.579 ± 0.018	1.969TyrSer: 1.969 ± 0.021	1.532TyrThr: 1.532 ± 0.018	1.592TyrVal: 1.592 ± 0.02	0.441TyrTrp: 0.441 ± 0.011	0.883TyrTyr: 0.883 ± 0.016	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 9830 proteins (4847146 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

---