Amino acid dipepetide frequency for Pedobacter duraquae

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	6.902AlaAla: 6.902 ± 0.096	0.615AlaCys: 0.615 ± 0.021	4.584AlaAsp: 4.584 ± 0.058	4.825AlaGlu: 4.825 ± 0.064	3.67AlaPhe: 3.67 ± 0.048	5.843AlaGly: 5.843 ± 0.079	1.263AlaHis: 1.263 ± 0.029	5.526AlaIle: 5.526 ± 0.067	4.789AlaLys: 4.789 ± 0.061	7.446AlaLeu: 7.446 ± 0.083	1.836AlaMet: 1.836 ± 0.031	3.785AlaAsn: 3.785 ± 0.054	2.312AlaPro: 2.312 ± 0.045	3.17AlaGln: 3.17 ± 0.05	2.6AlaArg: 2.6 ± 0.042	4.583AlaSer: 4.583 ± 0.055	4.444AlaThr: 4.444 ± 0.066	5.16AlaVal: 5.16 ± 0.063	0.787AlaTrp: 0.787 ± 0.025	3.079AlaTyr: 3.079 ± 0.043	0.0AlaXaa: 0.0 ± 0.0
Cys	0.528CysAla: 0.528 ± 0.017	0.12CysCys: 0.12 ± 0.008	0.336CysAsp: 0.336 ± 0.015	0.312CysGlu: 0.312 ± 0.015	0.433CysPhe: 0.433 ± 0.016	0.572CysGly: 0.572 ± 0.022	0.17CysHis: 0.17 ± 0.012	0.618CysIle: 0.618 ± 0.021	0.452CysLys: 0.452 ± 0.017	0.797CysLeu: 0.797 ± 0.023	0.17CysMet: 0.17 ± 0.01	0.33CysAsn: 0.33 ± 0.014	0.264CysPro: 0.264 ± 0.013	0.197CysGln: 0.197 ± 0.012	0.277CysArg: 0.277 ± 0.013	0.498CysSer: 0.498 ± 0.019	0.409CysThr: 0.409 ± 0.016	0.452CysVal: 0.452 ± 0.017	0.093CysTrp: 0.093 ± 0.008	0.288CysTyr: 0.288 ± 0.014	0.0CysXaa: 0.0 ± 0.0
Asp	4.076AspAla: 4.076 ± 0.052	0.353AspCys: 0.353 ± 0.015	2.506AspAsp: 2.506 ± 0.042	3.122AspGlu: 3.122 ± 0.049	3.151AspPhe: 3.151 ± 0.053	3.696AspGly: 3.696 ± 0.058	1.029AspHis: 1.029 ± 0.027	3.833AspIle: 3.833 ± 0.052	3.56AspLys: 3.56 ± 0.051	5.328AspLeu: 5.328 ± 0.069	1.199AspMet: 1.199 ± 0.028	2.521AspAsn: 2.521 ± 0.042	2.251AspPro: 2.251 ± 0.039	2.266AspGln: 2.266 ± 0.042	2.22AspArg: 2.22 ± 0.037	2.873AspSer: 2.873 ± 0.043	2.607AspThr: 2.607 ± 0.046	3.41AspVal: 3.41 ± 0.053	0.705AspTrp: 0.705 ± 0.02	2.573AspTyr: 2.573 ± 0.042	0.0AspXaa: 0.0 ± 0.0
Glu	4.04GluAla: 4.04 ± 0.062	0.281GluCys: 0.281 ± 0.013	2.659GluAsp: 2.659 ± 0.048	3.383GluGlu: 3.383 ± 0.071	2.39GluPhe: 2.39 ± 0.04	3.143GluGly: 3.143 ± 0.041	1.12GluHis: 1.12 ± 0.03	4.301GluIle: 4.301 ± 0.059	4.339GluLys: 4.339 ± 0.06	5.982GluLeu: 5.982 ± 0.08	1.364GluMet: 1.364 ± 0.033	3.144GluAsn: 3.144 ± 0.043	1.515GluPro: 1.515 ± 0.032	2.564GluGln: 2.564 ± 0.045	2.546GluArg: 2.546 ± 0.046	2.928GluSer: 2.928 ± 0.045	2.878GluThr: 2.878 ± 0.037	3.612GluVal: 3.612 ± 0.045	0.556GluTrp: 0.556 ± 0.018	1.786GluTyr: 1.786 ± 0.035	0.0GluXaa: 0.0 ± 0.0
Phe	3.487PheAla: 3.487 ± 0.052	0.482PheCys: 0.482 ± 0.018	2.909PheAsp: 2.909 ± 0.04	2.653PheGlu: 2.653 ± 0.047	2.491PhePhe: 2.491 ± 0.042	3.507PheGly: 3.507 ± 0.051	0.807PheHis: 0.807 ± 0.025	3.529PheIle: 3.529 ± 0.053	3.467PheLys: 3.467 ± 0.049	4.512PheLeu: 4.512 ± 0.059	1.164PheMet: 1.164 ± 0.024	3.068PheAsn: 3.068 ± 0.048	1.734PhePro: 1.734 ± 0.033	1.494PheGln: 1.494 ± 0.029	1.898PheArg: 1.898 ± 0.037	3.882PheSer: 3.882 ± 0.05	3.147PheThr: 3.147 ± 0.051	2.928PheVal: 2.928 ± 0.043	0.555PheTrp: 0.555 ± 0.022	2.11PheTyr: 2.11 ± 0.042	0.0PheXaa: 0.0 ± 0.0
Gly	4.883GlyAla: 4.883 ± 0.073	0.556GlyCys: 0.556 ± 0.022	3.317GlyAsp: 3.317 ± 0.052	3.012GlyGlu: 3.012 ± 0.043	3.684GlyPhe: 3.684 ± 0.046	4.861GlyGly: 4.861 ± 0.074	1.167GlyHis: 1.167 ± 0.026	5.572GlyIle: 5.572 ± 0.066	5.326GlyLys: 5.326 ± 0.065	6.559GlyLeu: 6.559 ± 0.073	1.754GlyMet: 1.754 ± 0.038	3.657GlyAsn: 3.657 ± 0.058	1.56GlyPro: 1.56 ± 0.034	2.265GlyGln: 2.265 ± 0.043	2.558GlyArg: 2.558 ± 0.041	4.509GlySer: 4.509 ± 0.062	4.374GlyThr: 4.374 ± 0.079	4.375GlyVal: 4.375 ± 0.058	0.865GlyTrp: 0.865 ± 0.025	3.162GlyTyr: 3.162 ± 0.049	0.0GlyXaa: 0.0 ± 0.0
His	1.246HisAla: 1.246 ± 0.028	0.163HisCys: 0.163 ± 0.009	0.87HisAsp: 0.87 ± 0.021	0.946HisGlu: 0.946 ± 0.024	1.088HisPhe: 1.088 ± 0.029	1.106HisGly: 1.106 ± 0.03	0.464HisHis: 0.464 ± 0.019	1.374HisIle: 1.374 ± 0.032	1.023HisLys: 1.023 ± 0.026	1.8HisLeu: 1.8 ± 0.037	0.357HisMet: 0.357 ± 0.015	0.878HisAsn: 0.878 ± 0.024	0.936HisPro: 0.936 ± 0.024	0.788HisGln: 0.788 ± 0.022	0.722HisArg: 0.722 ± 0.024	0.986HisSer: 0.986 ± 0.027	1.007HisThr: 1.007 ± 0.028	1.037HisVal: 1.037 ± 0.026	0.218HisTrp: 0.218 ± 0.011	0.789HisTyr: 0.789 ± 0.026	0.0HisXaa: 0.0 ± 0.0
Ile	6.183IleAla: 6.183 ± 0.06	0.712IleCys: 0.712 ± 0.022	4.264IleAsp: 4.264 ± 0.056	3.969IleGlu: 3.969 ± 0.055	3.268IlePhe: 3.268 ± 0.052	4.987IleGly: 4.987 ± 0.065	1.291IleHis: 1.291 ± 0.031	4.91IleIle: 4.91 ± 0.059	4.901IleLys: 4.901 ± 0.051	6.707IleLeu: 6.707 ± 0.081	1.373IleMet: 1.373 ± 0.03	4.236IleAsn: 4.236 ± 0.059	3.141IlePro: 3.141 ± 0.047	2.475IleGln: 2.475 ± 0.035	3.007IleArg: 3.007 ± 0.044	5.483IleSer: 5.483 ± 0.057	4.733IleThr: 4.733 ± 0.07	4.373IleVal: 4.373 ± 0.055	0.747IleTrp: 0.747 ± 0.022	2.665IleTyr: 2.665 ± 0.039	0.0IleXaa: 0.0 ± 0.0
Lys	5.086LysAla: 5.086 ± 0.062	0.272LysCys: 0.272 ± 0.015	4.067LysAsp: 4.067 ± 0.053	4.143LysGlu: 4.143 ± 0.065	2.646LysPhe: 2.646 ± 0.041	4.375LysGly: 4.375 ± 0.057	1.252LysHis: 1.252 ± 0.03	5.204LysIle: 5.204 ± 0.053	5.373LysLys: 5.373 ± 0.072	6.246LysLeu: 6.246 ± 0.068	1.901LysMet: 1.901 ± 0.034	4.155LysAsn: 4.155 ± 0.051	2.661LysPro: 2.661 ± 0.049	2.684LysGln: 2.684 ± 0.037	2.856LysArg: 2.856 ± 0.045	4.27LysSer: 4.27 ± 0.053	4.312LysThr: 4.312 ± 0.056	4.318LysVal: 4.318 ± 0.056	0.728LysTrp: 0.728 ± 0.023	2.726LysTyr: 2.726 ± 0.038	0.0LysXaa: 0.0 ± 0.0
Leu	7.149LeuAla: 7.149 ± 0.078	0.775LeuCys: 0.775 ± 0.027	4.991LeuAsp: 4.991 ± 0.064	4.953LeuGlu: 4.953 ± 0.069	4.797LeuPhe: 4.797 ± 0.056	5.928LeuGly: 5.928 ± 0.07	1.723LeuHis: 1.723 ± 0.031	7.226LeuIle: 7.226 ± 0.085	7.36LeuLys: 7.36 ± 0.078	9.81LeuLeu: 9.81 ± 0.101	2.212LeuMet: 2.212 ± 0.039	5.84LeuAsn: 5.84 ± 0.072	4.069LeuPro: 4.069 ± 0.058	3.699LeuGln: 3.699 ± 0.053	3.772LeuArg: 3.772 ± 0.05	7.461LeuSer: 7.461 ± 0.077	5.868LeuThr: 5.868 ± 0.071	5.669LeuVal: 5.669 ± 0.059	0.878LeuTrp: 0.878 ± 0.027	3.23LeuTyr: 3.23 ± 0.052	0.0LeuXaa: 0.0 ± 0.0
Met	1.801MetAla: 1.801 ± 0.031	0.143MetCys: 0.143 ± 0.009	1.286MetAsp: 1.286 ± 0.032	1.373MetGlu: 1.373 ± 0.032	0.849MetPhe: 0.849 ± 0.026	1.523MetGly: 1.523 ± 0.035	0.442MetHis: 0.442 ± 0.016	1.554MetIle: 1.554 ± 0.031	1.946MetLys: 1.946 ± 0.037	2.367MetLeu: 2.367 ± 0.041	0.623MetMet: 0.623 ± 0.023	1.232MetAsn: 1.232 ± 0.028	1.039MetPro: 1.039 ± 0.023	0.962MetGln: 0.962 ± 0.028	0.975MetArg: 0.975 ± 0.02	1.402MetSer: 1.402 ± 0.03	1.194MetThr: 1.194 ± 0.027	1.458MetVal: 1.458 ± 0.031	0.177MetTrp: 0.177 ± 0.01	0.698MetTyr: 0.698 ± 0.02	0.0MetXaa: 0.0 ± 0.0
Asn	4.184AsnAla: 4.184 ± 0.062	0.38AsnCys: 0.38 ± 0.018	2.641AsnAsp: 2.641 ± 0.048	2.726AsnGlu: 2.726 ± 0.039	2.814AsnPhe: 2.814 ± 0.041	3.948AsnGly: 3.948 ± 0.067	0.921AsnHis: 0.921 ± 0.025	4.072AsnIle: 4.072 ± 0.057	3.534AsnLys: 3.534 ± 0.051	5.181AsnLeu: 5.181 ± 0.058	1.278AsnMet: 1.278 ± 0.031	3.115AsnAsn: 3.115 ± 0.05	2.665AsnPro: 2.665 ± 0.044	2.077AsnGln: 2.077 ± 0.037	2.252AsnArg: 2.252 ± 0.04	3.355AsnSer: 3.355 ± 0.054	3.507AsnThr: 3.507 ± 0.07	3.186AsnVal: 3.186 ± 0.047	0.705AsnTrp: 0.705 ± 0.022	2.643AsnTyr: 2.643 ± 0.049	0.0AsnXaa: 0.0 ± 0.0
Pro	3.293ProAla: 3.293 ± 0.05	0.217ProCys: 0.217 ± 0.013	2.485ProAsp: 2.485 ± 0.044	2.93ProGlu: 2.93 ± 0.044	1.928ProPhe: 1.928 ± 0.035	2.811ProGly: 2.811 ± 0.048	0.589ProHis: 0.589 ± 0.02	2.393ProIle: 2.393 ± 0.033	2.201ProLys: 2.201 ± 0.042	3.281ProLeu: 3.281 ± 0.05	0.796ProMet: 0.796 ± 0.025	1.894ProAsn: 1.894 ± 0.042	0.89ProPro: 0.89 ± 0.028	1.306ProGln: 1.306 ± 0.031	1.068ProArg: 1.068 ± 0.027	2.096ProSer: 2.096 ± 0.032	1.985ProThr: 1.985 ± 0.043	3.135ProVal: 3.135 ± 0.047	0.345ProTrp: 0.345 ± 0.017	1.489ProTyr: 1.489 ± 0.033	0.0ProXaa: 0.0 ± 0.0
Gln	2.681GlnAla: 2.681 ± 0.045	0.178GlnCys: 0.178 ± 0.01	1.739GlnAsp: 1.739 ± 0.037	2.129GlnGlu: 2.129 ± 0.04	1.735GlnPhe: 1.735 ± 0.03	2.098GlnGly: 2.098 ± 0.036	0.843GlnHis: 0.843 ± 0.024	2.78GlnIle: 2.78 ± 0.039	2.641GlnLys: 2.641 ± 0.044	4.062GlnLeu: 4.062 ± 0.053	0.891GlnMet: 0.891 ± 0.025	2.015GlnAsn: 2.015 ± 0.037	1.412GlnPro: 1.412 ± 0.028	2.028GlnGln: 2.028 ± 0.05	1.588GlnArg: 1.588 ± 0.034	2.328GlnSer: 2.328 ± 0.038	2.204GlnThr: 2.204 ± 0.041	2.422GlnVal: 2.422 ± 0.039	0.375GlnTrp: 0.375 ± 0.018	1.474GlnTyr: 1.474 ± 0.031	0.0GlnXaa: 0.0 ± 0.0
Arg	2.586ArgAla: 2.586 ± 0.044	0.215ArgCys: 0.215 ± 0.013	1.96ArgAsp: 1.96 ± 0.038	2.086ArgGlu: 2.086 ± 0.04	2.211ArgPhe: 2.211 ± 0.036	2.168ArgGly: 2.168 ± 0.04	0.635ArgHis: 0.635 ± 0.019	3.194ArgIle: 3.194 ± 0.042	2.916ArgLys: 2.916 ± 0.043	3.978ArgLeu: 3.978 ± 0.054	1.089ArgMet: 1.089 ± 0.027	2.327ArgAsn: 2.327 ± 0.042	1.36ArgPro: 1.36 ± 0.03	1.453ArgGln: 1.453 ± 0.03	1.526ArgArg: 1.526 ± 0.034	2.548ArgSer: 2.548 ± 0.038	2.189ArgThr: 2.189 ± 0.041	2.346ArgVal: 2.346 ± 0.044	0.459ArgTrp: 0.459 ± 0.017	1.832ArgTyr: 1.832 ± 0.034	0.0ArgXaa: 0.0 ± 0.0
Ser	5.275SerAla: 5.275 ± 0.068	0.556SerCys: 0.556 ± 0.021	3.243SerAsp: 3.243 ± 0.041	3.051SerGlu: 3.051 ± 0.039	3.649SerPhe: 3.649 ± 0.057	5.217SerGly: 5.217 ± 0.076	1.004SerHis: 1.004 ± 0.022	4.841SerIle: 4.841 ± 0.052	4.07SerLys: 4.07 ± 0.054	6.304SerLeu: 6.304 ± 0.064	1.402SerMet: 1.402 ± 0.03	3.335SerAsn: 3.335 ± 0.053	2.309SerPro: 2.309 ± 0.039	1.956SerGln: 1.956 ± 0.04	2.566SerArg: 2.566 ± 0.037	4.28SerSer: 4.28 ± 0.059	3.891SerThr: 3.891 ± 0.054	4.327SerVal: 4.327 ± 0.06	0.765SerTrp: 0.765 ± 0.023	2.846SerTyr: 2.846 ± 0.05	0.0SerXaa: 0.0 ± 0.0
Thr	5.126ThrAla: 5.126 ± 0.083	0.364ThrCys: 0.364 ± 0.017	3.416ThrAsp: 3.416 ± 0.048	3.154ThrGlu: 3.154 ± 0.044	2.918ThrPhe: 2.918 ± 0.05	4.914ThrGly: 4.914 ± 0.085	1.007ThrHis: 1.007 ± 0.027	4.411ThrIle: 4.411 ± 0.067	3.408ThrLys: 3.408 ± 0.048	5.736ThrLeu: 5.736 ± 0.067	1.109ThrMet: 1.109 ± 0.024	2.95ThrAsn: 2.95 ± 0.056	2.601ThrPro: 2.601 ± 0.047	1.98ThrGln: 1.98 ± 0.034	1.972ThrArg: 1.972 ± 0.034	3.685ThrSer: 3.685 ± 0.058	3.768ThrThr: 3.768 ± 0.076	4.131ThrVal: 4.131 ± 0.068	0.641ThrTrp: 0.641 ± 0.019	2.488ThrTyr: 2.488 ± 0.048	0.0ThrXaa: 0.0 ± 0.0
Val	4.914ValAla: 4.914 ± 0.059	0.513ValCys: 0.513 ± 0.017	3.336ValAsp: 3.336 ± 0.047	3.286ValGlu: 3.286 ± 0.048	3.241ValPhe: 3.241 ± 0.046	3.783ValGly: 3.783 ± 0.058	1.012ValHis: 1.012 ± 0.024	4.801ValIle: 4.801 ± 0.06	4.593ValLys: 4.593 ± 0.052	6.207ValLeu: 6.207 ± 0.077	1.423ValMet: 1.423 ± 0.032	3.655ValAsn: 3.655 ± 0.049	2.442ValPro: 2.442 ± 0.043	2.091ValGln: 2.091 ± 0.038	2.352ValArg: 2.352 ± 0.038	4.473ValSer: 4.473 ± 0.051	3.947ValThr: 3.947 ± 0.066	4.425ValVal: 4.425 ± 0.057	0.663ValTrp: 0.663 ± 0.02	2.474ValTyr: 2.474 ± 0.038	0.0ValXaa: 0.0 ± 0.0
Trp	0.727TrpAla: 0.727 ± 0.022	0.109TrpCys: 0.109 ± 0.009	0.558TrpAsp: 0.558 ± 0.018	0.59TrpGlu: 0.59 ± 0.018	0.583TrpPhe: 0.583 ± 0.017	0.725TrpGly: 0.725 ± 0.023	0.237TrpHis: 0.237 ± 0.013	0.765TrpIle: 0.765 ± 0.022	0.807TrpLys: 0.807 ± 0.023	1.098TrpLeu: 1.098 ± 0.028	0.341TrpMet: 0.341 ± 0.016	0.627TrpAsn: 0.627 ± 0.02	0.325TrpPro: 0.325 ± 0.015	0.434TrpGln: 0.434 ± 0.018	0.445TrpArg: 0.445 ± 0.016	0.655TrpSer: 0.655 ± 0.021	0.638TrpThr: 0.638 ± 0.021	0.641TrpVal: 0.641 ± 0.021	0.172TrpTrp: 0.172 ± 0.012	0.448TrpTyr: 0.448 ± 0.016	0.0TrpXaa: 0.0 ± 0.0
Tyr	3.053TyrAla: 3.053 ± 0.038	0.313TyrCys: 0.313 ± 0.015	2.112TyrAsp: 2.112 ± 0.035	1.886TyrGlu: 1.886 ± 0.035	2.279TyrPhe: 2.279 ± 0.039	2.81TyrGly: 2.81 ± 0.05	0.822TyrHis: 0.822 ± 0.026	2.521TyrIle: 2.521 ± 0.041	2.565TyrLys: 2.565 ± 0.038	4.012TyrLeu: 4.012 ± 0.056	0.764TyrMet: 0.764 ± 0.023	2.419TyrAsn: 2.419 ± 0.045	1.646TyrPro: 1.646 ± 0.034	1.735TyrGln: 1.735 ± 0.035	1.879TyrArg: 1.879 ± 0.04	2.592TyrSer: 2.592 ± 0.042	2.677TyrThr: 2.677 ± 0.049	2.228TyrVal: 2.228 ± 0.038	0.489TyrTrp: 0.489 ± 0.018	1.823TyrTyr: 1.823 ± 0.041	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4663 proteins (1620024 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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