Amino acid dipepetide frequency for Streptococcus satellite phage Javan361

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
0.393AlaAla: 0.393 ± 0.34
0.393AlaCys: 0.393 ± 0.471
3.928AlaAsp: 3.928 ± 0.928
6.284AlaGlu: 6.284 ± 1.751
3.535AlaPhe: 3.535 ± 1.012
2.357AlaGly: 2.357 ± 0.69
0.0AlaHis: 0.0 ± 0.0
5.106AlaIle: 5.106 ± 1.521
5.106AlaLys: 5.106 ± 1.105
4.713AlaLeu: 4.713 ± 1.415
3.142AlaMet: 3.142 ± 1.018
1.178AlaAsn: 1.178 ± 0.495
1.178AlaPro: 1.178 ± 0.545
1.571AlaGln: 1.571 ± 0.871
4.321AlaArg: 4.321 ± 1.362
2.357AlaSer: 2.357 ± 0.968
3.142AlaThr: 3.142 ± 0.697
2.357AlaVal: 2.357 ± 0.773
0.786AlaTrp: 0.786 ± 0.54
1.571AlaTyr: 1.571 ± 0.712
0.0AlaXaa: 0.0 ± 0.0
Cys
0.393CysAla: 0.393 ± 0.441
0.0CysCys: 0.0 ± 0.0
0.0CysAsp: 0.0 ± 0.0
0.393CysGlu: 0.393 ± 0.278
0.393CysPhe: 0.393 ± 0.471
0.0CysGly: 0.0 ± 0.0
0.0CysHis: 0.0 ± 0.0
0.0CysIle: 0.0 ± 0.0
0.393CysLys: 0.393 ± 0.393
1.178CysLeu: 1.178 ± 0.793
0.393CysMet: 0.393 ± 0.409
0.393CysAsn: 0.393 ± 0.386
0.0CysPro: 0.0 ± 0.0
0.0CysGln: 0.0 ± 0.0
0.0CysArg: 0.0 ± 0.0
0.393CysSer: 0.393 ± 0.409
0.393CysThr: 0.393 ± 0.359
0.786CysVal: 0.786 ± 0.522
0.0CysTrp: 0.0 ± 0.0
0.0CysTyr: 0.0 ± 0.0
0.0CysXaa: 0.0 ± 0.0
Asp
1.571AspAla: 1.571 ± 0.956
0.0AspCys: 0.0 ± 0.0
2.357AspAsp: 2.357 ± 1.126
6.284AspGlu: 6.284 ± 1.533
2.749AspPhe: 2.749 ± 0.94
3.142AspGly: 3.142 ± 1.152
1.178AspHis: 1.178 ± 0.467
5.892AspIle: 5.892 ± 1.185
7.07AspLys: 7.07 ± 1.594
7.463AspLeu: 7.463 ± 1.881
1.571AspMet: 1.571 ± 0.696
3.535AspAsn: 3.535 ± 0.913
0.786AspPro: 0.786 ± 0.556
1.178AspGln: 1.178 ± 0.851
3.928AspArg: 3.928 ± 1.211
3.535AspSer: 3.535 ± 1.226
3.142AspThr: 3.142 ± 0.909
1.964AspVal: 1.964 ± 0.74
0.0AspTrp: 0.0 ± 0.0
3.928AspTyr: 3.928 ± 1.029
0.0AspXaa: 0.0 ± 0.0
Glu
5.106GluAla: 5.106 ± 2.163
0.786GluCys: 0.786 ± 0.493
3.928GluAsp: 3.928 ± 1.219
7.463GluGlu: 7.463 ± 2.414
2.749GluPhe: 2.749 ± 1.021
4.321GluGly: 4.321 ± 1.097
2.357GluHis: 2.357 ± 0.98
9.427GluIle: 9.427 ± 1.548
8.641GluLys: 8.641 ± 1.491
12.569GluLeu: 12.569 ± 2.39
2.357GluMet: 2.357 ± 0.851
3.535GluAsn: 3.535 ± 1.294
1.178GluPro: 1.178 ± 0.96
4.321GluGln: 4.321 ± 1.64
5.892GluArg: 5.892 ± 1.761
3.142GluSer: 3.142 ± 1.412
7.463GluThr: 7.463 ± 1.477
5.892GluVal: 5.892 ± 1.635
0.393GluTrp: 0.393 ± 0.359
3.928GluTyr: 3.928 ± 0.932
0.0GluXaa: 0.0 ± 0.0
Phe
2.749PheAla: 2.749 ± 1.156
0.0PheCys: 0.0 ± 0.0
4.713PheAsp: 4.713 ± 1.336
5.106PheGlu: 5.106 ± 1.673
2.749PhePhe: 2.749 ± 0.826
1.571PheGly: 1.571 ± 0.623
0.786PheHis: 0.786 ± 0.428
2.749PheIle: 2.749 ± 1.039
3.142PheLys: 3.142 ± 1.626
4.321PheLeu: 4.321 ± 1.235
0.786PheMet: 0.786 ± 0.625
1.178PheAsn: 1.178 ± 0.953
0.786PhePro: 0.786 ± 0.522
1.571PheGln: 1.571 ± 0.724
1.964PheArg: 1.964 ± 0.631
2.749PheSer: 2.749 ± 0.879
3.142PheThr: 3.142 ± 1.061
2.357PheVal: 2.357 ± 1.223
1.178PheTrp: 1.178 ± 0.562
1.571PheTyr: 1.571 ± 0.644
0.0PheXaa: 0.0 ± 0.0
Gly
3.142GlyAla: 3.142 ± 1.323
0.393GlyCys: 0.393 ± 0.359
1.571GlyAsp: 1.571 ± 0.763
2.749GlyGlu: 2.749 ± 1.055
1.178GlyPhe: 1.178 ± 0.477
1.178GlyGly: 1.178 ± 0.559
0.393GlyHis: 0.393 ± 0.359
3.142GlyIle: 3.142 ± 0.97
5.106GlyLys: 5.106 ± 1.28
5.499GlyLeu: 5.499 ± 1.44
1.178GlyMet: 1.178 ± 0.734
1.571GlyAsn: 1.571 ± 0.708
0.0GlyPro: 0.0 ± 0.0
1.178GlyGln: 1.178 ± 0.669
2.749GlyArg: 2.749 ± 0.863
1.571GlySer: 1.571 ± 0.808
1.964GlyThr: 1.964 ± 1.091
3.535GlyVal: 3.535 ± 0.837
1.571GlyTrp: 1.571 ± 0.818
3.535GlyTyr: 3.535 ± 0.666
0.0GlyXaa: 0.0 ± 0.0
His
2.357HisAla: 2.357 ± 1.341
0.0HisCys: 0.0 ± 0.0
0.786HisAsp: 0.786 ± 0.455
1.964HisGlu: 1.964 ± 0.762
1.178HisPhe: 1.178 ± 0.697
0.0HisGly: 0.0 ± 0.0
0.0HisHis: 0.0 ± 0.0
0.393HisIle: 0.393 ± 0.359
1.964HisLys: 1.964 ± 0.967
1.964HisLeu: 1.964 ± 1.008
0.0HisMet: 0.0 ± 0.0
0.393HisAsn: 0.393 ± 0.458
0.0HisPro: 0.0 ± 0.0
0.786HisGln: 0.786 ± 0.556
0.786HisArg: 0.786 ± 0.882
0.786HisSer: 0.786 ± 0.54
1.964HisThr: 1.964 ± 1.036
0.0HisVal: 0.0 ± 0.0
0.0HisTrp: 0.0 ± 0.0
0.786HisTyr: 0.786 ± 0.556
0.0HisXaa: 0.0 ± 0.0
Ile
3.928IleAla: 3.928 ± 1.353
0.786IleCys: 0.786 ± 0.548
5.106IleAsp: 5.106 ± 1.041
7.07IleGlu: 7.07 ± 2.278
1.964IlePhe: 1.964 ± 0.904
1.571IleGly: 1.571 ± 0.687
0.393IleHis: 0.393 ± 0.34
3.142IleIle: 3.142 ± 1.453
5.892IleLys: 5.892 ± 1.499
5.892IleLeu: 5.892 ± 1.136
0.786IleMet: 0.786 ± 0.538
2.749IleAsn: 2.749 ± 0.754
2.357IlePro: 2.357 ± 0.664
2.749IleGln: 2.749 ± 1.149
2.749IleArg: 2.749 ± 1.088
3.928IleSer: 3.928 ± 1.171
3.535IleThr: 3.535 ± 1.07
3.142IleVal: 3.142 ± 1.039
0.786IleTrp: 0.786 ± 0.689
3.142IleTyr: 3.142 ± 0.768
0.0IleXaa: 0.0 ± 0.0
Lys
8.248LysAla: 8.248 ± 2.102
0.0LysCys: 0.0 ± 0.0
7.463LysAsp: 7.463 ± 1.896
10.212LysGlu: 10.212 ± 2.234
4.713LysPhe: 4.713 ± 1.364
5.892LysGly: 5.892 ± 1.372
2.357LysHis: 2.357 ± 1.29
7.07LysIle: 7.07 ± 1.4
10.998LysLys: 10.998 ± 1.659
8.248LysLeu: 8.248 ± 1.537
2.357LysMet: 2.357 ± 1.024
5.892LysAsn: 5.892 ± 1.539
1.964LysPro: 1.964 ± 0.78
3.535LysGln: 3.535 ± 1.157
5.499LysArg: 5.499 ± 1.118
7.463LysSer: 7.463 ± 1.28
7.07LysThr: 7.07 ± 2.063
6.284LysVal: 6.284 ± 1.524
1.571LysTrp: 1.571 ± 0.597
4.713LysTyr: 4.713 ± 1.26
0.0LysXaa: 0.0 ± 0.0
Leu
4.713LeuAla: 4.713 ± 1.33
0.393LeuCys: 0.393 ± 0.409
7.07LeuAsp: 7.07 ± 1.971
9.819LeuGlu: 9.819 ± 1.675
5.499LeuPhe: 5.499 ± 1.46
4.713LeuGly: 4.713 ± 1.421
1.178LeuHis: 1.178 ± 0.844
3.535LeuIle: 3.535 ± 1.029
11.783LeuLys: 11.783 ± 1.693
7.855LeuLeu: 7.855 ± 2.186
1.964LeuMet: 1.964 ± 0.597
6.677LeuAsn: 6.677 ± 1.539
2.749LeuPro: 2.749 ± 0.806
1.964LeuGln: 1.964 ± 0.777
3.535LeuArg: 3.535 ± 1.374
7.463LeuSer: 7.463 ± 2.074
7.855LeuThr: 7.855 ± 1.625
4.713LeuVal: 4.713 ± 1.094
0.393LeuTrp: 0.393 ± 0.337
3.535LeuTyr: 3.535 ± 1.123
0.0LeuXaa: 0.0 ± 0.0
Met
0.786MetAla: 0.786 ± 0.494
0.0MetCys: 0.0 ± 0.0
1.571MetAsp: 1.571 ± 0.532
4.321MetGlu: 4.321 ± 1.718
0.786MetPhe: 0.786 ± 0.657
0.0MetGly: 0.0 ± 0.0
0.0MetHis: 0.0 ± 0.0
2.749MetIle: 2.749 ± 1.084
1.964MetLys: 1.964 ± 0.788
1.964MetLeu: 1.964 ± 0.639
0.786MetMet: 0.786 ± 0.455
1.964MetAsn: 1.964 ± 0.752
0.393MetPro: 0.393 ± 0.383
0.786MetGln: 0.786 ± 0.464
1.178MetArg: 1.178 ± 0.734
0.786MetSer: 0.786 ± 0.601
1.178MetThr: 1.178 ± 0.579
1.571MetVal: 1.571 ± 0.852
0.0MetTrp: 0.0 ± 0.0
0.393MetTyr: 0.393 ± 0.278
0.0MetXaa: 0.0 ± 0.0
Asn
1.964AsnAla: 1.964 ± 0.755
0.393AsnCys: 0.393 ± 0.359
1.178AsnAsp: 1.178 ± 0.835
3.928AsnGlu: 3.928 ± 1.196
2.357AsnPhe: 2.357 ± 0.928
4.321AsnGly: 4.321 ± 1.511
0.393AsnHis: 0.393 ± 0.359
1.964AsnIle: 1.964 ± 0.748
6.677AsnLys: 6.677 ± 1.003
6.677AsnLeu: 6.677 ± 2.236
1.571AsnMet: 1.571 ± 0.833
2.357AsnAsn: 2.357 ± 0.913
1.964AsnPro: 1.964 ± 0.716
2.357AsnGln: 2.357 ± 1.033
0.786AsnArg: 0.786 ± 0.475
2.749AsnSer: 2.749 ± 1.048
2.749AsnThr: 2.749 ± 0.924
0.786AsnVal: 0.786 ± 0.615
0.786AsnTrp: 0.786 ± 0.449
2.357AsnTyr: 2.357 ± 0.917
0.0AsnXaa: 0.0 ± 0.0
Pro
0.786ProAla: 0.786 ± 0.428
0.0ProCys: 0.0 ± 0.0
1.178ProAsp: 1.178 ± 0.679
1.571ProGlu: 1.571 ± 0.86
1.964ProPhe: 1.964 ± 0.775
0.786ProGly: 0.786 ± 0.45
0.393ProHis: 0.393 ± 0.458
0.393ProIle: 0.393 ± 0.386
4.321ProLys: 4.321 ± 1.636
1.571ProLeu: 1.571 ± 0.589
0.786ProMet: 0.786 ± 0.638
0.786ProAsn: 0.786 ± 0.555
1.571ProPro: 1.571 ± 0.849
0.786ProGln: 0.786 ± 0.689
0.786ProArg: 0.786 ± 0.428
1.571ProSer: 1.571 ± 0.61
1.571ProThr: 1.571 ± 0.634
1.178ProVal: 1.178 ± 0.478
0.0ProTrp: 0.0 ± 0.0
1.178ProTyr: 1.178 ± 0.478
0.0ProXaa: 0.0 ± 0.0
Gln
5.892GlnAla: 5.892 ± 1.417
0.0GlnCys: 0.0 ± 0.0
1.571GlnAsp: 1.571 ± 0.791
1.964GlnGlu: 1.964 ± 0.768
1.571GlnPhe: 1.571 ± 0.782
1.964GlnGly: 1.964 ± 0.696
1.178GlnHis: 1.178 ± 0.737
2.357GlnIle: 2.357 ± 0.803
4.713GlnLys: 4.713 ± 1.578
1.964GlnLeu: 1.964 ± 0.902
0.393GlnMet: 0.393 ± 0.443
2.357GlnAsn: 2.357 ± 0.674
0.393GlnPro: 0.393 ± 0.42
2.749GlnGln: 2.749 ± 1.029
3.142GlnArg: 3.142 ± 1.095
0.393GlnSer: 0.393 ± 0.495
2.749GlnThr: 2.749 ± 1.163
1.964GlnVal: 1.964 ± 0.944
0.393GlnTrp: 0.393 ± 0.374
1.178GlnTyr: 1.178 ± 0.432
0.0GlnXaa: 0.0 ± 0.0
Arg
2.749ArgAla: 2.749 ± 0.968
0.0ArgCys: 0.0 ± 0.0
3.928ArgAsp: 3.928 ± 0.891
4.321ArgGlu: 4.321 ± 1.378
1.178ArgPhe: 1.178 ± 0.602
2.357ArgGly: 2.357 ± 0.954
1.178ArgHis: 1.178 ± 0.478
2.749ArgIle: 2.749 ± 0.846
5.499ArgLys: 5.499 ± 1.244
5.892ArgLeu: 5.892 ± 1.081
1.178ArgMet: 1.178 ± 0.629
2.749ArgAsn: 2.749 ± 0.599
0.786ArgPro: 0.786 ± 0.405
3.535ArgGln: 3.535 ± 1.117
2.749ArgArg: 2.749 ± 1.031
2.749ArgSer: 2.749 ± 0.788
1.964ArgThr: 1.964 ± 0.601
0.786ArgVal: 0.786 ± 0.428
0.393ArgTrp: 0.393 ± 0.495
3.928ArgTyr: 3.928 ± 1.23
0.0ArgXaa: 0.0 ± 0.0
Ser
1.964SerAla: 1.964 ± 0.899
0.786SerCys: 0.786 ± 0.455
3.535SerAsp: 3.535 ± 0.995
6.677SerGlu: 6.677 ± 1.274
3.142SerPhe: 3.142 ± 1.076
2.357SerGly: 2.357 ± 0.797
1.571SerHis: 1.571 ± 0.843
3.142SerIle: 3.142 ± 1.09
4.713SerLys: 4.713 ± 1.182
5.106SerLeu: 5.106 ± 1.069
1.571SerMet: 1.571 ± 0.765
1.178SerAsn: 1.178 ± 0.572
2.749SerPro: 2.749 ± 0.915
1.571SerGln: 1.571 ± 0.764
0.393SerArg: 0.393 ± 0.278
3.928SerSer: 3.928 ± 0.991
2.749SerThr: 2.749 ± 0.939
3.535SerVal: 3.535 ± 0.774
0.393SerTrp: 0.393 ± 0.409
4.321SerTyr: 4.321 ± 1.142
0.0SerXaa: 0.0 ± 0.0
Thr
1.964ThrAla: 1.964 ± 0.616
0.393ThrCys: 0.393 ± 0.409
3.928ThrAsp: 3.928 ± 1.25
4.713ThrGlu: 4.713 ± 1.295
2.749ThrPhe: 2.749 ± 1.025
3.535ThrGly: 3.535 ± 0.938
1.178ThrHis: 1.178 ± 0.59
4.713ThrIle: 4.713 ± 1.068
8.248ThrLys: 8.248 ± 1.469
5.499ThrLeu: 5.499 ± 1.025
0.393ThrMet: 0.393 ± 0.359
2.749ThrAsn: 2.749 ± 0.933
2.749ThrPro: 2.749 ± 0.624
3.535ThrGln: 3.535 ± 1.652
3.928ThrArg: 3.928 ± 1.307
1.964ThrSer: 1.964 ± 0.801
1.964ThrThr: 1.964 ± 0.74
3.928ThrVal: 3.928 ± 1.244
0.393ThrTrp: 0.393 ± 0.441
3.535ThrTyr: 3.535 ± 1.657
0.0ThrXaa: 0.0 ± 0.0
Val
3.535ValAla: 3.535 ± 1.12
0.393ValCys: 0.393 ± 0.471
3.535ValAsp: 3.535 ± 0.826
5.892ValGlu: 5.892 ± 1.064
2.749ValPhe: 2.749 ± 1.063
1.178ValGly: 1.178 ± 0.573
0.393ValHis: 0.393 ± 0.278
0.786ValIle: 0.786 ± 0.717
6.284ValLys: 6.284 ± 1.366
3.142ValLeu: 3.142 ± 0.976
0.393ValMet: 0.393 ± 0.449
3.928ValAsn: 3.928 ± 1.453
0.393ValPro: 0.393 ± 0.42
1.178ValGln: 1.178 ± 0.713
2.357ValArg: 2.357 ± 0.846
2.749ValSer: 2.749 ± 0.879
4.713ValThr: 4.713 ± 1.303
3.142ValVal: 3.142 ± 0.859
0.393ValTrp: 0.393 ± 0.386
2.357ValTyr: 2.357 ± 0.611
0.0ValXaa: 0.0 ± 0.0
Trp
0.393TrpAla: 0.393 ± 0.359
0.393TrpCys: 0.393 ± 0.278
0.393TrpAsp: 0.393 ± 0.471
1.964TrpGlu: 1.964 ± 0.714
0.0TrpPhe: 0.0 ± 0.0
0.393TrpGly: 0.393 ± 0.278
0.0TrpHis: 0.0 ± 0.0
0.786TrpIle: 0.786 ± 0.523
1.571TrpLys: 1.571 ± 0.661
0.393TrpLeu: 0.393 ± 0.374
0.0TrpMet: 0.0 ± 0.0
0.0TrpAsn: 0.0 ± 0.0
0.0TrpPro: 0.0 ± 0.0
0.786TrpGln: 0.786 ± 0.459
0.393TrpArg: 0.393 ± 0.458
0.393TrpSer: 0.393 ± 0.359
1.178TrpThr: 1.178 ± 0.648
0.393TrpVal: 0.393 ± 0.386
0.0TrpTrp: 0.0 ± 0.0
0.0TrpTyr: 0.0 ± 0.0
0.0TrpXaa: 0.0 ± 0.0
Tyr
0.786TyrAla: 0.786 ± 0.455
0.0TyrCys: 0.0 ± 0.0
3.535TyrAsp: 3.535 ± 1.098
2.749TyrGlu: 2.749 ± 0.93
1.964TyrPhe: 1.964 ± 0.647
1.571TyrGly: 1.571 ± 0.491
1.178TyrHis: 1.178 ± 0.514
1.964TyrIle: 1.964 ± 0.81
7.463TyrLys: 7.463 ± 1.498
5.499TyrLeu: 5.499 ± 1.264
1.178TyrMet: 1.178 ± 0.588
3.142TyrAsn: 3.142 ± 0.958
1.178TyrPro: 1.178 ± 0.59
2.749TyrGln: 2.749 ± 0.634
3.535TyrArg: 3.535 ± 1.284
4.713TyrSer: 4.713 ± 1.05
1.571TyrThr: 1.571 ± 0.793
1.178TyrVal: 1.178 ± 0.604
0.0TyrTrp: 0.0 ± 0.0
3.142TyrTyr: 3.142 ± 0.953
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 18 proteins (2547 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski