Amino acid dipepetide frequency for Modestobacter sp. DSM 44400

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	24.361AlaAla: 24.361 ± 0.199	1.041AlaCys: 1.041 ± 0.026	9.291AlaAsp: 9.291 ± 0.082	8.572AlaGlu: 8.572 ± 0.085	3.327AlaPhe: 3.327 ± 0.056	15.442AlaGly: 15.442 ± 0.152	2.693AlaHis: 2.693 ± 0.043	3.747AlaIle: 3.747 ± 0.06	1.855AlaLys: 1.855 ± 0.043	14.936AlaLeu: 14.936 ± 0.134	2.576AlaMet: 2.576 ± 0.043	1.81AlaAsn: 1.81 ± 0.036	7.306AlaPro: 7.306 ± 0.1	3.927AlaGln: 3.927 ± 0.062	10.506AlaArg: 10.506 ± 0.088	5.966AlaSer: 5.966 ± 0.076	7.865AlaThr: 7.865 ± 0.077	14.004AlaVal: 14.004 ± 0.13	1.889AlaTrp: 1.889 ± 0.044	2.224AlaTyr: 2.224 ± 0.039	0.0AlaXaa: 0.0 ± 0.0
Cys	0.968CysAla: 0.968 ± 0.026	0.133CysCys: 0.133 ± 0.01	0.421CysAsp: 0.421 ± 0.02	0.32CysGlu: 0.32 ± 0.014	0.213CysPhe: 0.213 ± 0.013	0.935CysGly: 0.935 ± 0.026	0.158CysHis: 0.158 ± 0.011	0.19CysIle: 0.19 ± 0.012	0.07CysLys: 0.07 ± 0.008	0.646CysLeu: 0.646 ± 0.022	0.121CysMet: 0.121 ± 0.01	0.118CysAsn: 0.118 ± 0.01	0.528CysPro: 0.528 ± 0.021	0.163CysGln: 0.163 ± 0.01	0.642CysArg: 0.642 ± 0.022	0.471CysSer: 0.471 ± 0.017	0.517CysThr: 0.517 ± 0.019	0.579CysVal: 0.579 ± 0.02	0.136CysTrp: 0.136 ± 0.01	0.125CysTyr: 0.125 ± 0.009	0.0CysXaa: 0.0 ± 0.0
Asp	8.16AspAla: 8.16 ± 0.091	0.377AspCys: 0.377 ± 0.018	4.094AspAsp: 4.094 ± 0.066	3.76AspGlu: 3.76 ± 0.056	1.328AspPhe: 1.328 ± 0.036	6.3AspGly: 6.3 ± 0.075	1.252AspHis: 1.252 ± 0.03	1.466AspIle: 1.466 ± 0.036	0.801AspLys: 0.801 ± 0.025	6.788AspLeu: 6.788 ± 0.073	0.794AspMet: 0.794 ± 0.026	0.745AspAsn: 0.745 ± 0.028	4.703AspPro: 4.703 ± 0.056	1.772AspGln: 1.772 ± 0.037	5.396AspArg: 5.396 ± 0.062	2.423AspSer: 2.423 ± 0.046	2.891AspThr: 2.891 ± 0.047	6.432AspVal: 6.432 ± 0.069	0.925AspTrp: 0.925 ± 0.024	1.029AspTyr: 1.029 ± 0.027	0.0AspXaa: 0.0 ± 0.0
Glu	6.304GluAla: 6.304 ± 0.071	0.311GluCys: 0.311 ± 0.015	2.661GluAsp: 2.661 ± 0.043	2.894GluGlu: 2.894 ± 0.061	1.315GluPhe: 1.315 ± 0.035	3.746GluGly: 3.746 ± 0.052	1.53GluHis: 1.53 ± 0.038	1.737GluIle: 1.737 ± 0.04	0.864GluLys: 0.864 ± 0.028	6.92GluLeu: 6.92 ± 0.068	0.785GluMet: 0.785 ± 0.024	0.752GluAsn: 0.752 ± 0.021	3.101GluPro: 3.101 ± 0.049	2.353GluGln: 2.353 ± 0.039	4.821GluArg: 4.821 ± 0.066	2.312GluSer: 2.312 ± 0.042	2.49GluThr: 2.49 ± 0.04	5.153GluVal: 5.153 ± 0.057	0.699GluTrp: 0.699 ± 0.023	0.842GluTyr: 0.842 ± 0.027	0.0GluXaa: 0.0 ± 0.0
Phe	3.599PheAla: 3.599 ± 0.054	0.246PheCys: 0.246 ± 0.013	1.909PheAsp: 1.909 ± 0.044	1.155PheGlu: 1.155 ± 0.028	0.824PhePhe: 0.824 ± 0.029	2.916PheGly: 2.916 ± 0.049	0.478PheHis: 0.478 ± 0.019	0.686PheIle: 0.686 ± 0.026	0.312PheLys: 0.312 ± 0.017	2.508PheLeu: 2.508 ± 0.05	0.317PheMet: 0.317 ± 0.013	0.436PheAsn: 0.436 ± 0.019	1.342PhePro: 1.342 ± 0.035	0.602PheGln: 0.602 ± 0.02	1.663PheArg: 1.663 ± 0.035	1.445PheSer: 1.445 ± 0.032	1.786PheThr: 1.786 ± 0.038	2.215PheVal: 2.215 ± 0.041	0.368PheTrp: 0.368 ± 0.017	0.525PheTyr: 0.525 ± 0.023	0.0PheXaa: 0.0 ± 0.0
Gly	11.813GlyAla: 11.813 ± 0.108	0.869GlyCys: 0.869 ± 0.028	5.373GlyAsp: 5.373 ± 0.069	4.817GlyGlu: 4.817 ± 0.067	2.728GlyPhe: 2.728 ± 0.046	8.945GlyGly: 8.945 ± 0.101	2.137GlyHis: 2.137 ± 0.039	3.263GlyIle: 3.263 ± 0.053	1.794GlyLys: 1.794 ± 0.041	10.129GlyLeu: 10.129 ± 0.1	2.119GlyMet: 2.119 ± 0.038	1.632GlyAsn: 1.632 ± 0.036	5.4GlyPro: 5.4 ± 0.063	3.025GlyGln: 3.025 ± 0.042	8.11GlyArg: 8.11 ± 0.081	5.718GlySer: 5.718 ± 0.066	6.092GlyThr: 6.092 ± 0.069	8.488GlyVal: 8.488 ± 0.085	1.856GlyTrp: 1.856 ± 0.037	2.191GlyTyr: 2.191 ± 0.04	0.0GlyXaa: 0.0 ± 0.0
His	2.441HisAla: 2.441 ± 0.044	0.196HisCys: 0.196 ± 0.012	1.231HisAsp: 1.231 ± 0.028	1.017HisGlu: 1.017 ± 0.028	0.531HisPhe: 0.531 ± 0.021	2.157HisGly: 2.157 ± 0.043	0.596HisHis: 0.596 ± 0.024	0.456HisIle: 0.456 ± 0.02	0.223HisLys: 0.223 ± 0.013	2.35HisLeu: 2.35 ± 0.042	0.271HisMet: 0.271 ± 0.015	0.318HisAsn: 0.318 ± 0.016	1.732HisPro: 1.732 ± 0.034	0.605HisGln: 0.605 ± 0.021	2.031HisArg: 2.031 ± 0.038	0.957HisSer: 0.957 ± 0.029	1.072HisThr: 1.072 ± 0.026	1.887HisVal: 1.887 ± 0.032	0.324HisTrp: 0.324 ± 0.016	0.383HisTyr: 0.383 ± 0.017	0.0HisXaa: 0.0 ± 0.0
Ile	4.644IleAla: 4.644 ± 0.058	0.262IleCys: 0.262 ± 0.012	2.186IleAsp: 2.186 ± 0.046	1.792IleGlu: 1.792 ± 0.045	0.544IlePhe: 0.544 ± 0.021	3.455IleGly: 3.455 ± 0.06	0.414IleHis: 0.414 ± 0.018	0.781IleIle: 0.781 ± 0.026	0.46IleLys: 0.46 ± 0.016	1.823IleLeu: 1.823 ± 0.043	0.354IleMet: 0.354 ± 0.016	0.608IleAsn: 0.608 ± 0.023	1.596IlePro: 1.596 ± 0.038	0.577IleGln: 0.577 ± 0.022	1.937IleArg: 1.937 ± 0.036	1.684IleSer: 1.684 ± 0.036	2.016IleThr: 2.016 ± 0.04	2.615IleVal: 2.615 ± 0.048	0.341IleTrp: 0.341 ± 0.015	0.485IleTyr: 0.485 ± 0.02	0.0IleXaa: 0.0 ± 0.0
Lys	1.939LysAla: 1.939 ± 0.04	0.065LysCys: 0.065 ± 0.007	0.836LysAsp: 0.836 ± 0.028	0.666LysGlu: 0.666 ± 0.024	0.286LysPhe: 0.286 ± 0.014	1.122LysGly: 1.122 ± 0.034	0.308LysHis: 0.308 ± 0.015	0.547LysIle: 0.547 ± 0.022	0.463LysLys: 0.463 ± 0.02	1.436LysLeu: 1.436 ± 0.032	0.259LysMet: 0.259 ± 0.014	0.314LysAsn: 0.314 ± 0.016	0.895LysPro: 0.895 ± 0.032	0.513LysGln: 0.513 ± 0.022	1.099LysArg: 1.099 ± 0.028	0.785LysSer: 0.785 ± 0.026	0.968LysThr: 0.968 ± 0.031	1.407LysVal: 1.407 ± 0.033	0.172LysTrp: 0.172 ± 0.012	0.307LysTyr: 0.307 ± 0.014	0.0LysXaa: 0.0 ± 0.0
Leu	17.05LeuAla: 17.05 ± 0.151	0.672LeuCys: 0.672 ± 0.024	6.892LeuAsp: 6.892 ± 0.073	4.552LeuGlu: 4.552 ± 0.063	2.505LeuPhe: 2.505 ± 0.048	9.936LeuGly: 9.936 ± 0.095	2.146LeuHis: 2.146 ± 0.038	2.9LeuIle: 2.9 ± 0.05	1.272LeuLys: 1.272 ± 0.033	11.789LeuLeu: 11.789 ± 0.129	1.413LeuMet: 1.413 ± 0.03	1.364LeuAsn: 1.364 ± 0.031	6.756LeuPro: 6.756 ± 0.078	2.65LeuGln: 2.65 ± 0.043	8.366LeuArg: 8.366 ± 0.092	5.615LeuSer: 5.615 ± 0.064	7.143LeuThr: 7.143 ± 0.065	10.576LeuVal: 10.576 ± 0.109	1.153LeuTrp: 1.153 ± 0.03	1.536LeuTyr: 1.536 ± 0.031	0.0LeuXaa: 0.0 ± 0.0
Met	2.278MetAla: 2.278 ± 0.044	0.122MetCys: 0.122 ± 0.009	0.849MetAsp: 0.849 ± 0.024	0.611MetGlu: 0.611 ± 0.022	0.392MetPhe: 0.392 ± 0.017	1.325MetGly: 1.325 ± 0.037	0.343MetHis: 0.343 ± 0.018	0.586MetIle: 0.586 ± 0.019	0.297MetLys: 0.297 ± 0.013	1.615MetLeu: 1.615 ± 0.034	0.251MetMet: 0.251 ± 0.013	0.347MetAsn: 0.347 ± 0.016	1.059MetPro: 1.059 ± 0.021	0.469MetGln: 0.469 ± 0.018	1.383MetArg: 1.383 ± 0.035	1.355MetSer: 1.355 ± 0.028	1.613MetThr: 1.613 ± 0.034	1.339MetVal: 1.339 ± 0.032	0.169MetTrp: 0.169 ± 0.011	0.255MetTyr: 0.255 ± 0.013	0.0MetXaa: 0.0 ± 0.0
Asn	2.013AsnAla: 2.013 ± 0.039	0.138AsnCys: 0.138 ± 0.009	0.889AsnAsp: 0.889 ± 0.025	0.672AsnGlu: 0.672 ± 0.023	0.407AsnPhe: 0.407 ± 0.018	1.565AsnGly: 1.565 ± 0.032	0.284AsnHis: 0.284 ± 0.015	0.472AsnIle: 0.472 ± 0.021	0.267AsnLys: 0.267 ± 0.013	1.495AsnLeu: 1.495 ± 0.032	0.263AsnMet: 0.263 ± 0.014	0.312AsnAsn: 0.312 ± 0.017	1.23AsnPro: 1.23 ± 0.029	0.43AsnGln: 0.43 ± 0.018	1.145AsnArg: 1.145 ± 0.031	0.781AsnSer: 0.781 ± 0.026	0.88AsnThr: 0.88 ± 0.031	1.342AsnVal: 1.342 ± 0.037	0.25AsnTrp: 0.25 ± 0.013	0.328AsnTyr: 0.328 ± 0.017	0.0AsnXaa: 0.0 ± 0.0
Pro	9.826ProAla: 9.826 ± 0.108	0.315ProCys: 0.315 ± 0.015	4.601ProAsp: 4.601 ± 0.064	3.726ProGlu: 3.726 ± 0.051	1.504ProPhe: 1.504 ± 0.035	6.893ProGly: 6.893 ± 0.079	1.203ProHis: 1.203 ± 0.03	1.423ProIle: 1.423 ± 0.033	0.842ProLys: 0.842 ± 0.025	5.327ProLeu: 5.327 ± 0.062	1.027ProMet: 1.027 ± 0.029	0.809ProAsn: 0.809 ± 0.023	3.66ProPro: 3.66 ± 0.07	1.605ProGln: 1.605 ± 0.033	4.078ProArg: 4.078 ± 0.05	3.145ProSer: 3.145 ± 0.049	3.688ProThr: 3.688 ± 0.056	6.171ProVal: 6.171 ± 0.08	0.95ProTrp: 0.95 ± 0.024	1.003ProTyr: 1.003 ± 0.026	0.0ProXaa: 0.0 ± 0.0
Gln	3.956GlnAla: 3.956 ± 0.065	0.161GlnCys: 0.161 ± 0.01	1.206GlnAsp: 1.206 ± 0.031	1.206GlnGlu: 1.206 ± 0.03	0.727GlnPhe: 0.727 ± 0.023	1.971GlnGly: 1.971 ± 0.036	0.686GlnHis: 0.686 ± 0.025	0.9GlnIle: 0.9 ± 0.026	0.436GlnLys: 0.436 ± 0.018	3.801GlnLeu: 3.801 ± 0.057	0.494GlnMet: 0.494 ± 0.021	0.391GlnAsn: 0.391 ± 0.018	1.836GlnPro: 1.836 ± 0.042	1.297GlnGln: 1.297 ± 0.038	2.695GlnArg: 2.695 ± 0.047	1.213GlnSer: 1.213 ± 0.027	1.514GlnThr: 1.514 ± 0.035	3.086GlnVal: 3.086 ± 0.044	0.416GlnTrp: 0.416 ± 0.019	0.563GlnTyr: 0.563 ± 0.02	0.0GlnXaa: 0.0 ± 0.0
Arg	10.43ArgAla: 10.43 ± 0.095	0.648ArgCys: 0.648 ± 0.023	4.3ArgAsp: 4.3 ± 0.064	4.046ArgGlu: 4.046 ± 0.053	2.137ArgPhe: 2.137 ± 0.04	6.229ArgGly: 6.229 ± 0.064	1.844ArgHis: 1.844 ± 0.036	2.521ArgIle: 2.521 ± 0.049	1.168ArgLys: 1.168 ± 0.027	8.757ArgLeu: 8.757 ± 0.092	1.789ArgMet: 1.789 ± 0.034	1.295ArgAsn: 1.295 ± 0.033	5.342ArgPro: 5.342 ± 0.066	2.409ArgGln: 2.409 ± 0.043	8.436ArgArg: 8.436 ± 0.094	4.576ArgSer: 4.576 ± 0.059	5.031ArgThr: 5.031 ± 0.061	6.573ArgVal: 6.573 ± 0.066	1.53ArgTrp: 1.53 ± 0.035	1.71ArgTyr: 1.71 ± 0.034	0.0ArgXaa: 0.0 ± 0.0
Ser	7.174SerAla: 7.174 ± 0.083	0.399SerCys: 0.399 ± 0.017	2.748SerAsp: 2.748 ± 0.045	2.174SerGlu: 2.174 ± 0.038	1.447SerPhe: 1.447 ± 0.033	5.786SerGly: 5.786 ± 0.08	0.881SerHis: 0.881 ± 0.024	1.61SerIle: 1.61 ± 0.037	0.701SerLys: 0.701 ± 0.023	4.91SerLeu: 4.91 ± 0.066	1.183SerMet: 1.183 ± 0.028	0.831SerAsn: 0.831 ± 0.026	3.4SerPro: 3.4 ± 0.05	1.22SerGln: 1.22 ± 0.031	3.965SerArg: 3.965 ± 0.053	3.221SerSer: 3.221 ± 0.058	3.453SerThr: 3.453 ± 0.06	4.486SerVal: 4.486 ± 0.061	0.915SerTrp: 0.915 ± 0.026	1.06SerTyr: 1.06 ± 0.029	0.0SerXaa: 0.0 ± 0.0
Thr	9.104ThrAla: 9.104 ± 0.085	0.458ThrCys: 0.458 ± 0.017	3.783ThrAsp: 3.783 ± 0.059	2.944ThrGlu: 2.944 ± 0.047	1.566ThrPhe: 1.566 ± 0.035	6.856ThrGly: 6.856 ± 0.067	1.039ThrHis: 1.039 ± 0.03	1.766ThrIle: 1.766 ± 0.039	0.828ThrLys: 0.828 ± 0.027	5.608ThrLeu: 5.608 ± 0.055	0.967ThrMet: 0.967 ± 0.025	0.941ThrAsn: 0.941 ± 0.026	4.077ThrPro: 4.077 ± 0.058	1.314ThrGln: 1.314 ± 0.029	4.153ThrArg: 4.153 ± 0.056	3.383ThrSer: 3.383 ± 0.053	4.197ThrThr: 4.197 ± 0.08	6.293ThrVal: 6.293 ± 0.077	0.891ThrTrp: 0.891 ± 0.022	1.112ThrTyr: 1.112 ± 0.027	0.0ThrXaa: 0.0 ± 0.0
Val	13.108ValAla: 13.108 ± 0.113	0.717ValCys: 0.717 ± 0.024	6.186ValAsp: 6.186 ± 0.073	5.082ValGlu: 5.082 ± 0.062	2.585ValPhe: 2.585 ± 0.041	8.004ValGly: 8.004 ± 0.078	2.153ValHis: 2.153 ± 0.041	2.76ValIle: 2.76 ± 0.049	1.246ValLys: 1.246 ± 0.031	11.606ValLeu: 11.606 ± 0.125	1.249ValMet: 1.249 ± 0.03	1.518ValAsn: 1.518 ± 0.039	6.01ValPro: 6.01 ± 0.082	2.573ValGln: 2.573 ± 0.044	7.401ValArg: 7.401 ± 0.075	4.574ValSer: 4.574 ± 0.057	6.084ValThr: 6.084 ± 0.071	10.603ValVal: 10.603 ± 0.108	1.096ValTrp: 1.096 ± 0.032	1.478ValTyr: 1.478 ± 0.033	0.0ValXaa: 0.0 ± 0.0
Trp	1.755TrpAla: 1.755 ± 0.039	0.167TrpCys: 0.167 ± 0.01	0.761TrpAsp: 0.761 ± 0.023	0.597TrpGlu: 0.597 ± 0.022	0.45TrpPhe: 0.45 ± 0.019	1.022TrpGly: 1.022 ± 0.026	0.356TrpHis: 0.356 ± 0.016	0.414TrpIle: 0.414 ± 0.016	0.22TrpLys: 0.22 ± 0.012	1.877TrpLeu: 1.877 ± 0.043	0.25TrpMet: 0.25 ± 0.014	0.307TrpAsn: 0.307 ± 0.013	0.862TrpPro: 0.862 ± 0.025	0.554TrpGln: 0.554 ± 0.02	1.331TrpArg: 1.331 ± 0.032	1.026TrpSer: 1.026 ± 0.03	0.982TrpThr: 0.982 ± 0.031	1.158TrpVal: 1.158 ± 0.032	0.347TrpTrp: 0.347 ± 0.017	0.275TrpTyr: 0.275 ± 0.014	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.417TyrAla: 2.417 ± 0.036	0.156TyrCys: 0.156 ± 0.011	1.219TyrAsp: 1.219 ± 0.028	0.986TyrGlu: 0.986 ± 0.027	0.517TyrPhe: 0.517 ± 0.019	1.894TyrGly: 1.894 ± 0.044	0.277TyrHis: 0.277 ± 0.014	0.349TyrIle: 0.349 ± 0.016	0.271TyrLys: 0.271 ± 0.014	1.969TyrLeu: 1.969 ± 0.041	0.178TyrMet: 0.178 ± 0.011	0.314TyrAsn: 0.314 ± 0.014	0.957TyrPro: 0.957 ± 0.028	0.498TyrGln: 0.498 ± 0.02	1.611TyrArg: 1.611 ± 0.038	0.912TyrSer: 0.912 ± 0.025	0.997TyrThr: 0.997 ± 0.029	1.626TyrVal: 1.626 ± 0.032	0.286TyrTrp: 0.286 ± 0.015	0.352TyrTyr: 0.352 ± 0.017	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 5140 proteins (1452836 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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