Amino acid dipepetide frequency for Streptoalloteichus hindustanus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	21.031AlaAla: 21.031 ± 0.18	1.039AlaCys: 1.039 ± 0.023	8.399AlaAsp: 8.399 ± 0.07	9.845AlaGlu: 9.845 ± 0.095	3.368AlaPhe: 3.368 ± 0.042	12.989AlaGly: 12.989 ± 0.101	2.985AlaHis: 2.985 ± 0.042	3.131AlaIle: 3.131 ± 0.04	2.229AlaLys: 2.229 ± 0.044	15.177AlaLeu: 15.177 ± 0.144	2.393AlaMet: 2.393 ± 0.032	2.162AlaAsn: 2.162 ± 0.038	6.965AlaPro: 6.965 ± 0.078	3.344AlaGln: 3.344 ± 0.047	11.392AlaArg: 11.392 ± 0.097	5.632AlaSer: 5.632 ± 0.057	7.046AlaThr: 7.046 ± 0.065	13.394AlaVal: 13.394 ± 0.114	1.925AlaTrp: 1.925 ± 0.03	2.165AlaTyr: 2.165 ± 0.037	0.0AlaXaa: 0.0 ± 0.0
Cys	1.172CysAla: 1.172 ± 0.025	0.112CysCys: 0.112 ± 0.007	0.503CysAsp: 0.503 ± 0.016	0.393CysGlu: 0.393 ± 0.014	0.236CysPhe: 0.236 ± 0.011	0.977CysGly: 0.977 ± 0.023	0.218CysHis: 0.218 ± 0.011	0.098CysIle: 0.098 ± 0.007	0.078CysLys: 0.078 ± 0.005	0.863CysLeu: 0.863 ± 0.02	0.102CysMet: 0.102 ± 0.007	0.113CysAsn: 0.113 ± 0.007	0.563CysPro: 0.563 ± 0.019	0.234CysGln: 0.234 ± 0.01	0.705CysArg: 0.705 ± 0.019	0.45CysSer: 0.45 ± 0.016	0.399CysThr: 0.399 ± 0.015	0.809CysVal: 0.809 ± 0.021	0.165CysTrp: 0.165 ± 0.01	0.175CysTyr: 0.175 ± 0.01	0.0CysXaa: 0.0 ± 0.0
Asp	7.502AspAla: 7.502 ± 0.062	0.429AspCys: 0.429 ± 0.015	3.535AspAsp: 3.535 ± 0.047	4.056AspGlu: 4.056 ± 0.049	1.482AspPhe: 1.482 ± 0.03	5.94AspGly: 5.94 ± 0.059	1.562AspHis: 1.562 ± 0.026	1.419AspIle: 1.419 ± 0.03	0.874AspLys: 0.874 ± 0.026	6.727AspLeu: 6.727 ± 0.059	0.718AspMet: 0.718 ± 0.02	1.011AspAsn: 1.011 ± 0.024	4.725AspPro: 4.725 ± 0.053	1.909AspGln: 1.909 ± 0.034	5.483AspArg: 5.483 ± 0.055	2.356AspSer: 2.356 ± 0.039	2.686AspThr: 2.686 ± 0.042	5.425AspVal: 5.425 ± 0.053	0.979AspTrp: 0.979 ± 0.023	1.122AspTyr: 1.122 ± 0.026	0.0AspXaa: 0.0 ± 0.0
Glu	6.744GluAla: 6.744 ± 0.074	0.39GluCys: 0.39 ± 0.015	2.675GluAsp: 2.675 ± 0.039	3.135GluGlu: 3.135 ± 0.047	1.61GluPhe: 1.61 ± 0.027	3.73GluGly: 3.73 ± 0.042	1.803GluHis: 1.803 ± 0.032	2.2GluIle: 2.2 ± 0.033	1.079GluLys: 1.079 ± 0.027	7.501GluLeu: 7.501 ± 0.067	0.831GluMet: 0.831 ± 0.02	0.956GluAsn: 0.956 ± 0.022	3.741GluPro: 3.741 ± 0.056	2.137GluGln: 2.137 ± 0.037	6.26GluArg: 6.26 ± 0.06	2.258GluSer: 2.258 ± 0.034	2.579GluThr: 2.579 ± 0.037	5.313GluVal: 5.313 ± 0.057	0.891GluTrp: 0.891 ± 0.024	0.954GluTyr: 0.954 ± 0.02	0.0GluXaa: 0.0 ± 0.0
Phe	3.745PheAla: 3.745 ± 0.044	0.289PheCys: 0.289 ± 0.01	1.988PheAsp: 1.988 ± 0.036	1.256PheGlu: 1.256 ± 0.025	0.824PhePhe: 0.824 ± 0.025	3.028PheGly: 3.028 ± 0.045	0.661PheHis: 0.661 ± 0.017	0.406PheIle: 0.406 ± 0.014	0.289PheLys: 0.289 ± 0.013	2.724PheLeu: 2.724 ± 0.037	0.283PheMet: 0.283 ± 0.013	0.457PheAsn: 0.457 ± 0.017	1.46PhePro: 1.46 ± 0.029	0.614PheGln: 0.614 ± 0.016	2.089PheArg: 2.089 ± 0.03	1.273PheSer: 1.273 ± 0.023	1.72PheThr: 1.72 ± 0.031	2.551PheVal: 2.551 ± 0.037	0.407PheTrp: 0.407 ± 0.013	0.523PheTyr: 0.523 ± 0.016	0.0PheXaa: 0.0 ± 0.0
Gly	10.932GlyAla: 10.932 ± 0.081	0.908GlyCys: 0.908 ± 0.021	5.051GlyAsp: 5.051 ± 0.057	5.24GlyGlu: 5.24 ± 0.05	2.793GlyPhe: 2.793 ± 0.041	8.566GlyGly: 8.566 ± 0.109	2.24GlyHis: 2.24 ± 0.038	2.687GlyIle: 2.687 ± 0.041	1.815GlyLys: 1.815 ± 0.038	9.287GlyLeu: 9.287 ± 0.076	1.904GlyMet: 1.904 ± 0.032	1.653GlyAsn: 1.653 ± 0.036	5.164GlyPro: 5.164 ± 0.061	2.967GlyGln: 2.967 ± 0.051	8.274GlyArg: 8.274 ± 0.079	4.749GlySer: 4.749 ± 0.052	4.979GlyThr: 4.979 ± 0.054	8.764GlyVal: 8.764 ± 0.082	1.854GlyTrp: 1.854 ± 0.037	2.108GlyTyr: 2.108 ± 0.034	0.0GlyXaa: 0.0 ± 0.0
His	2.886HisAla: 2.886 ± 0.04	0.248HisCys: 0.248 ± 0.01	1.417HisAsp: 1.417 ± 0.029	1.271HisGlu: 1.271 ± 0.025	0.622HisPhe: 0.622 ± 0.016	2.485HisGly: 2.485 ± 0.039	0.812HisHis: 0.812 ± 0.026	0.485HisIle: 0.485 ± 0.013	0.275HisLys: 0.275 ± 0.014	2.573HisLeu: 2.573 ± 0.038	0.277HisMet: 0.277 ± 0.012	0.407HisAsn: 0.407 ± 0.014	1.912HisPro: 1.912 ± 0.037	0.708HisGln: 0.708 ± 0.022	2.384HisArg: 2.384 ± 0.037	1.035HisSer: 1.035 ± 0.022	1.168HisThr: 1.168 ± 0.025	2.097HisVal: 2.097 ± 0.036	0.374HisTrp: 0.374 ± 0.013	0.487HisTyr: 0.487 ± 0.018	0.0HisXaa: 0.0 ± 0.0
Ile	3.948IleAla: 3.948 ± 0.051	0.249IleCys: 0.249 ± 0.011	1.805IleAsp: 1.805 ± 0.036	1.524IleGlu: 1.524 ± 0.034	0.52IlePhe: 0.52 ± 0.017	2.818IleGly: 2.818 ± 0.042	0.506IleHis: 0.506 ± 0.014	0.604IleIle: 0.604 ± 0.02	0.447IleLys: 0.447 ± 0.016	1.768IleLeu: 1.768 ± 0.034	0.315IleMet: 0.315 ± 0.014	0.568IleAsn: 0.568 ± 0.018	1.52IlePro: 1.52 ± 0.027	0.577IleGln: 0.577 ± 0.019	2.008IleArg: 2.008 ± 0.032	1.455IleSer: 1.455 ± 0.03	1.966IleThr: 1.966 ± 0.033	2.231IleVal: 2.231 ± 0.039	0.299IleTrp: 0.299 ± 0.011	0.48IleTyr: 0.48 ± 0.016	0.0IleXaa: 0.0 ± 0.0
Lys	2.019LysAla: 2.019 ± 0.049	0.095LysCys: 0.095 ± 0.007	0.852LysAsp: 0.852 ± 0.03	0.789LysGlu: 0.789 ± 0.022	0.378LysPhe: 0.378 ± 0.015	1.182LysGly: 1.182 ± 0.03	0.352LysHis: 0.352 ± 0.013	0.642LysIle: 0.642 ± 0.02	0.492LysLys: 0.492 ± 0.021	1.556LysLeu: 1.556 ± 0.036	0.29LysMet: 0.29 ± 0.012	0.367LysAsn: 0.367 ± 0.014	1.1LysPro: 1.1 ± 0.024	0.521LysGln: 0.521 ± 0.019	1.158LysArg: 1.158 ± 0.027	0.788LysSer: 0.788 ± 0.022	0.826LysThr: 0.826 ± 0.021	1.532LysVal: 1.532 ± 0.032	0.211LysTrp: 0.211 ± 0.011	0.31LysTyr: 0.31 ± 0.016	0.0LysXaa: 0.0 ± 0.0
Leu	16.795LeuAla: 16.795 ± 0.146	0.844LeuCys: 0.844 ± 0.02	7.021LeuAsp: 7.021 ± 0.068	4.273LeuGlu: 4.273 ± 0.05	2.598LeuPhe: 2.598 ± 0.043	9.723LeuGly: 9.723 ± 0.091	2.343LeuHis: 2.343 ± 0.034	2.156LeuIle: 2.156 ± 0.036	1.136LeuLys: 1.136 ± 0.031	11.652LeuLeu: 11.652 ± 0.127	1.321LeuMet: 1.321 ± 0.028	1.504LeuAsn: 1.504 ± 0.028	6.844LeuPro: 6.844 ± 0.071	1.811LeuGln: 1.811 ± 0.032	10.442LeuArg: 10.442 ± 0.082	5.413LeuSer: 5.413 ± 0.056	6.503LeuThr: 6.503 ± 0.057	11.425LeuVal: 11.425 ± 0.097	1.35LeuTrp: 1.35 ± 0.028	1.486LeuTyr: 1.486 ± 0.027	0.0LeuXaa: 0.0 ± 0.0
Met	2.174MetAla: 2.174 ± 0.033	0.113MetCys: 0.113 ± 0.007	0.746MetAsp: 0.746 ± 0.02	0.582MetGlu: 0.582 ± 0.018	0.414MetPhe: 0.414 ± 0.013	1.187MetGly: 1.187 ± 0.029	0.276MetHis: 0.276 ± 0.011	0.519MetIle: 0.519 ± 0.015	0.265MetLys: 0.265 ± 0.013	1.575MetLeu: 1.575 ± 0.029	0.23MetMet: 0.23 ± 0.011	0.335MetAsn: 0.335 ± 0.013	1.001MetPro: 1.001 ± 0.022	0.306MetGln: 0.306 ± 0.015	1.555MetArg: 1.555 ± 0.029	1.247MetSer: 1.247 ± 0.025	1.432MetThr: 1.432 ± 0.028	1.343MetVal: 1.343 ± 0.025	0.19MetTrp: 0.19 ± 0.009	0.225MetTyr: 0.225 ± 0.01	0.0MetXaa: 0.0 ± 0.0
Asn	2.223AsnAla: 2.223 ± 0.037	0.169AsnCys: 0.169 ± 0.009	0.876AsnAsp: 0.876 ± 0.022	0.74AsnGlu: 0.74 ± 0.021	0.428AsnPhe: 0.428 ± 0.014	1.741AsnGly: 1.741 ± 0.04	0.435AsnHis: 0.435 ± 0.015	0.51AsnIle: 0.51 ± 0.019	0.325AsnLys: 0.325 ± 0.014	1.668AsnLeu: 1.668 ± 0.032	0.247AsnMet: 0.247 ± 0.011	0.43AsnAsn: 0.43 ± 0.018	1.465AsnPro: 1.465 ± 0.029	0.542AsnGln: 0.542 ± 0.017	1.403AsnArg: 1.403 ± 0.031	0.766AsnSer: 0.766 ± 0.024	1.069AsnThr: 1.069 ± 0.027	1.353AsnVal: 1.353 ± 0.026	0.271AsnTrp: 0.271 ± 0.012	0.395AsnTyr: 0.395 ± 0.015	0.0AsnXaa: 0.0 ± 0.0
Pro	8.892ProAla: 8.892 ± 0.101	0.411ProCys: 0.411 ± 0.015	4.761ProAsp: 4.761 ± 0.059	4.557ProGlu: 4.557 ± 0.053	1.546ProPhe: 1.546 ± 0.029	6.622ProGly: 6.622 ± 0.081	1.505ProHis: 1.505 ± 0.028	1.215ProIle: 1.215 ± 0.027	0.988ProLys: 0.988 ± 0.024	5.472ProLeu: 5.472 ± 0.061	0.961ProMet: 0.961 ± 0.022	1.097ProAsn: 1.097 ± 0.027	4.373ProPro: 4.373 ± 0.097	1.487ProGln: 1.487 ± 0.033	4.706ProArg: 4.706 ± 0.053	3.178ProSer: 3.178 ± 0.044	3.772ProThr: 3.772 ± 0.051	6.037ProVal: 6.037 ± 0.055	1.012ProTrp: 1.012 ± 0.02	1.0ProTyr: 1.0 ± 0.025	0.0ProXaa: 0.0 ± 0.0
Gln	3.306GlnAla: 3.306 ± 0.05	0.179GlnCys: 0.179 ± 0.01	1.261GlnAsp: 1.261 ± 0.026	1.248GlnGlu: 1.248 ± 0.024	0.662GlnPhe: 0.662 ± 0.02	1.992GlnGly: 1.992 ± 0.035	0.725GlnHis: 0.725 ± 0.022	0.914GlnIle: 0.914 ± 0.025	0.445GlnLys: 0.445 ± 0.018	2.991GlnLeu: 2.991 ± 0.044	0.405GlnMet: 0.405 ± 0.017	0.435GlnAsn: 0.435 ± 0.015	1.983GlnPro: 1.983 ± 0.043	1.105GlnGln: 1.105 ± 0.032	2.84GlnArg: 2.84 ± 0.036	1.143GlnSer: 1.143 ± 0.027	1.109GlnThr: 1.109 ± 0.021	2.653GlnVal: 2.653 ± 0.039	0.437GlnTrp: 0.437 ± 0.014	0.47GlnTyr: 0.47 ± 0.018	0.0GlnXaa: 0.0 ± 0.0
Arg	11.414ArgAla: 11.414 ± 0.096	0.802ArgCys: 0.802 ± 0.022	4.9ArgAsp: 4.9 ± 0.055	5.26ArgGlu: 5.26 ± 0.057	2.674ArgPhe: 2.674 ± 0.04	6.65ArgGly: 6.65 ± 0.057	2.391ArgHis: 2.391 ± 0.036	2.802ArgIle: 2.802 ± 0.04	1.401ArgLys: 1.401 ± 0.029	9.821ArgLeu: 9.821 ± 0.094	1.98ArgMet: 1.98 ± 0.031	1.491ArgAsn: 1.491 ± 0.029	5.826ArgPro: 5.826 ± 0.062	2.78ArgGln: 2.78 ± 0.04	9.767ArgArg: 9.767 ± 0.092	4.321ArgSer: 4.321 ± 0.052	5.051ArgThr: 5.051 ± 0.048	7.783ArgVal: 7.783 ± 0.07	1.786ArgTrp: 1.786 ± 0.032	1.911ArgTyr: 1.911 ± 0.033	0.0ArgXaa: 0.0 ± 0.0
Ser	6.782SerAla: 6.782 ± 0.057	0.456SerCys: 0.456 ± 0.016	2.496SerAsp: 2.496 ± 0.035	2.167SerGlu: 2.167 ± 0.037	1.449SerPhe: 1.449 ± 0.026	5.58SerGly: 5.58 ± 0.052	0.942SerHis: 0.942 ± 0.023	1.097SerIle: 1.097 ± 0.025	0.722SerLys: 0.722 ± 0.021	4.542SerLeu: 4.542 ± 0.053	0.913SerMet: 0.913 ± 0.02	0.727SerAsn: 0.727 ± 0.021	3.239SerPro: 3.239 ± 0.045	1.109SerGln: 1.109 ± 0.023	3.807SerArg: 3.807 ± 0.041	2.598SerSer: 2.598 ± 0.043	3.131SerThr: 3.131 ± 0.036	4.287SerVal: 4.287 ± 0.048	0.951SerTrp: 0.951 ± 0.02	1.014SerTyr: 1.014 ± 0.022	0.0SerXaa: 0.0 ± 0.0
Thr	8.024ThrAla: 8.024 ± 0.068	0.461ThrCys: 0.461 ± 0.015	3.123ThrAsp: 3.123 ± 0.047	3.081ThrGlu: 3.081 ± 0.044	1.45ThrPhe: 1.45 ± 0.03	5.942ThrGly: 5.942 ± 0.05	1.207ThrHis: 1.207 ± 0.025	1.483ThrIle: 1.483 ± 0.025	0.885ThrLys: 0.885 ± 0.023	5.167ThrLeu: 5.167 ± 0.051	0.845ThrMet: 0.845 ± 0.02	1.008ThrAsn: 1.008 ± 0.025	4.047ThrPro: 4.047 ± 0.051	1.134ThrGln: 1.134 ± 0.022	4.313ThrArg: 4.313 ± 0.047	3.04ThrSer: 3.04 ± 0.042	3.86ThrThr: 3.86 ± 0.052	5.663ThrVal: 5.663 ± 0.05	0.931ThrTrp: 0.931 ± 0.02	1.006ThrTyr: 1.006 ± 0.023	0.0ThrXaa: 0.0 ± 0.0
Val	13.109ValAla: 13.109 ± 0.101	0.812ValCys: 0.812 ± 0.018	6.488ValAsp: 6.488 ± 0.06	5.684ValGlu: 5.684 ± 0.056	2.448ValPhe: 2.448 ± 0.04	7.994ValGly: 7.994 ± 0.073	2.13ValHis: 2.13 ± 0.035	2.501ValIle: 2.501 ± 0.039	1.205ValLys: 1.205 ± 0.029	11.388ValLeu: 11.388 ± 0.098	1.207ValMet: 1.207 ± 0.024	1.677ValAsn: 1.677 ± 0.029	5.687ValPro: 5.687 ± 0.057	1.866ValGln: 1.866 ± 0.029	8.635ValArg: 8.635 ± 0.075	4.539ValSer: 4.539 ± 0.05	5.482ValThr: 5.482 ± 0.055	10.628ValVal: 10.628 ± 0.105	1.219ValTrp: 1.219 ± 0.029	1.379ValTyr: 1.379 ± 0.027	0.0ValXaa: 0.0 ± 0.0
Trp	1.793TrpAla: 1.793 ± 0.03	0.185TrpCys: 0.185 ± 0.008	0.83TrpAsp: 0.83 ± 0.023	0.738TrpGlu: 0.738 ± 0.019	0.53TrpPhe: 0.53 ± 0.019	1.059TrpGly: 1.059 ± 0.025	0.411TrpHis: 0.411 ± 0.012	0.475TrpIle: 0.475 ± 0.015	0.27TrpLys: 0.27 ± 0.012	2.024TrpLeu: 2.024 ± 0.033	0.312TrpMet: 0.312 ± 0.013	0.346TrpAsn: 0.346 ± 0.015	0.924TrpPro: 0.924 ± 0.019	0.557TrpGln: 0.557 ± 0.014	1.719TrpArg: 1.719 ± 0.029	0.946TrpSer: 0.946 ± 0.023	0.962TrpThr: 0.962 ± 0.023	1.206TrpVal: 1.206 ± 0.027	0.421TrpTrp: 0.421 ± 0.014	0.295TrpTyr: 0.295 ± 0.014	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.124TyrAla: 2.124 ± 0.031	0.172TyrCys: 0.172 ± 0.009	1.212TyrAsp: 1.212 ± 0.032	0.945TyrGlu: 0.945 ± 0.023	0.556TyrPhe: 0.556 ± 0.016	1.727TyrGly: 1.727 ± 0.034	0.419TyrHis: 0.419 ± 0.012	0.263TyrIle: 0.263 ± 0.011	0.24TyrLys: 0.24 ± 0.012	2.162TyrLeu: 2.162 ± 0.036	0.182TyrMet: 0.182 ± 0.01	0.313TyrAsn: 0.313 ± 0.015	1.055TyrPro: 1.055 ± 0.027	0.594TyrGln: 0.594 ± 0.019	1.872TyrArg: 1.872 ± 0.03	0.821TyrSer: 0.821 ± 0.02	0.929TyrThr: 0.929 ± 0.024	1.583TyrVal: 1.583 ± 0.029	0.332TyrTrp: 0.332 ± 0.012	0.41TyrTyr: 0.41 ± 0.015	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 6533 proteins (2076377 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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