Amino acid dipepetide frequency for Desmodium leaf distortion virus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
5.634AlaAla: 5.634 ± 1.638
0.704AlaCys: 0.704 ± 0.665
1.408AlaAsp: 1.408 ± 0.666
2.113AlaGlu: 2.113 ± 1.378
0.0AlaPhe: 0.0 ± 0.0
2.817AlaGly: 2.817 ± 1.089
2.113AlaHis: 2.113 ± 1.059
2.113AlaIle: 2.113 ± 0.723
4.93AlaLys: 4.93 ± 1.148
4.225AlaLeu: 4.225 ± 1.538
0.0AlaMet: 0.0 ± 0.0
4.225AlaAsn: 4.225 ± 1.15
2.817AlaPro: 2.817 ± 0.904
2.817AlaGln: 2.817 ± 1.703
6.338AlaArg: 6.338 ± 2.455
9.155AlaSer: 9.155 ± 1.36
4.225AlaThr: 4.225 ± 1.616
2.817AlaVal: 2.817 ± 1.466
0.0AlaTrp: 0.0 ± 0.0
1.408AlaTyr: 1.408 ± 0.881
0.0AlaXaa: 0.0 ± 0.0
Cys
0.704CysAla: 0.704 ± 0.614
0.0CysCys: 0.0 ± 0.0
0.704CysAsp: 0.704 ± 0.588
1.408CysGlu: 1.408 ± 0.688
0.0CysPhe: 0.0 ± 0.0
0.704CysGly: 0.704 ± 0.848
0.0CysHis: 0.0 ± 0.0
1.408CysIle: 1.408 ± 0.787
2.817CysLys: 2.817 ± 0.898
0.704CysLeu: 0.704 ± 0.588
0.704CysMet: 0.704 ± 0.614
1.408CysAsn: 1.408 ± 0.666
0.0CysPro: 0.0 ± 0.0
0.0CysGln: 0.0 ± 0.0
0.0CysArg: 0.0 ± 0.0
1.408CysSer: 1.408 ± 0.995
2.113CysThr: 2.113 ± 1.7
1.408CysVal: 1.408 ± 0.787
1.408CysTrp: 1.408 ± 1.255
0.0CysTyr: 0.0 ± 0.0
0.0CysXaa: 0.0 ± 0.0
Asp
2.113AspAla: 2.113 ± 0.611
1.408AspCys: 1.408 ± 1.696
3.521AspAsp: 3.521 ± 2.285
4.225AspGlu: 4.225 ± 0.939
2.817AspPhe: 2.817 ± 0.904
1.408AspGly: 1.408 ± 0.687
0.704AspHis: 0.704 ± 0.614
4.225AspIle: 4.225 ± 0.705
1.408AspLys: 1.408 ± 0.666
7.042AspLeu: 7.042 ± 2.515
1.408AspMet: 1.408 ± 0.678
1.408AspAsn: 1.408 ± 0.787
2.817AspPro: 2.817 ± 1.231
1.408AspGln: 1.408 ± 0.881
2.817AspArg: 2.817 ± 1.481
4.225AspSer: 4.225 ± 0.595
1.408AspThr: 1.408 ± 0.791
5.634AspVal: 5.634 ± 0.753
0.0AspTrp: 0.0 ± 0.0
2.817AspTyr: 2.817 ± 0.957
0.0AspXaa: 0.0 ± 0.0
Glu
2.113GluAla: 2.113 ± 1.094
0.704GluCys: 0.704 ± 0.614
0.704GluAsp: 0.704 ± 0.749
2.113GluGlu: 2.113 ± 1.359
0.704GluPhe: 0.704 ± 0.628
5.634GluGly: 5.634 ± 2.501
0.704GluHis: 0.704 ± 0.588
4.93GluIle: 4.93 ± 3.025
1.408GluLys: 1.408 ± 0.791
3.521GluLeu: 3.521 ± 1.188
0.704GluMet: 0.704 ± 0.588
6.338GluAsn: 6.338 ± 2.492
2.113GluPro: 2.113 ± 0.723
1.408GluGln: 1.408 ± 1.329
3.521GluArg: 3.521 ± 1.192
5.634GluSer: 5.634 ± 2.098
0.0GluThr: 0.0 ± 0.0
1.408GluVal: 1.408 ± 0.687
2.113GluTrp: 2.113 ± 0.923
2.113GluTyr: 2.113 ± 1.138
0.0GluXaa: 0.0 ± 0.0
Phe
2.113PheAla: 2.113 ± 0.907
0.704PheCys: 0.704 ± 0.665
2.817PheAsp: 2.817 ± 0.528
0.0PheGlu: 0.0 ± 0.0
1.408PhePhe: 1.408 ± 0.666
2.113PheGly: 2.113 ± 0.723
2.113PheHis: 2.113 ± 1.359
2.113PheIle: 2.113 ± 1.114
4.225PheLys: 4.225 ± 1.784
1.408PheLeu: 1.408 ± 1.175
0.0PheMet: 0.0 ± 0.0
3.521PheAsn: 3.521 ± 0.93
2.817PhePro: 2.817 ± 1.065
1.408PheGln: 1.408 ± 1.032
2.113PheArg: 2.113 ± 0.883
3.521PheSer: 3.521 ± 2.025
2.113PheThr: 2.113 ± 0.965
0.0PheVal: 0.0 ± 0.0
2.113PheTrp: 2.113 ± 1.434
2.817PheTyr: 2.817 ± 1.511
0.0PheXaa: 0.0 ± 0.0
Gly
2.817GlyAla: 2.817 ± 0.957
1.408GlyCys: 1.408 ± 0.973
2.113GlyAsp: 2.113 ± 1.359
3.521GlyGlu: 3.521 ± 1.404
1.408GlyPhe: 1.408 ± 0.968
3.521GlyGly: 3.521 ± 1.458
1.408GlyHis: 1.408 ± 0.968
2.113GlyIle: 2.113 ± 0.994
6.338GlyLys: 6.338 ± 1.559
2.817GlyLeu: 2.817 ± 1.444
1.408GlyMet: 1.408 ± 1.159
2.817GlyAsn: 2.817 ± 1.481
6.338GlyPro: 6.338 ± 0.855
2.817GlyGln: 2.817 ± 1.377
2.817GlyArg: 2.817 ± 0.899
0.704GlySer: 0.704 ± 0.628
4.93GlyThr: 4.93 ± 1.34
3.521GlyVal: 3.521 ± 1.055
0.0GlyTrp: 0.0 ± 0.0
0.704GlyTyr: 0.704 ± 0.628
0.0GlyXaa: 0.0 ± 0.0
His
1.408HisAla: 1.408 ± 0.787
2.113HisCys: 2.113 ± 0.965
3.521HisAsp: 3.521 ± 1.25
1.408HisGlu: 1.408 ± 0.85
0.704HisPhe: 0.704 ± 0.614
1.408HisGly: 1.408 ± 1.004
0.704HisHis: 0.704 ± 0.848
2.113HisIle: 2.113 ± 1.444
1.408HisLys: 1.408 ± 0.988
2.113HisLeu: 2.113 ± 1.378
0.0HisMet: 0.0 ± 0.0
3.521HisAsn: 3.521 ± 1.722
2.817HisPro: 2.817 ± 1.249
3.521HisGln: 3.521 ± 1.674
2.817HisArg: 2.817 ± 2.504
2.817HisSer: 2.817 ± 1.094
1.408HisThr: 1.408 ± 1.329
3.521HisVal: 3.521 ± 1.65
0.704HisTrp: 0.704 ± 0.588
0.704HisTyr: 0.704 ± 0.614
0.0HisXaa: 0.0 ± 0.0
Ile
0.0IleAla: 0.0 ± 0.0
0.0IleCys: 0.0 ± 0.0
3.521IleAsp: 3.521 ± 1.87
4.93IleGlu: 4.93 ± 2.115
1.408IlePhe: 1.408 ± 1.175
3.521IleGly: 3.521 ± 1.055
2.817IleHis: 2.817 ± 1.438
3.521IleIle: 3.521 ± 1.743
5.634IleLys: 5.634 ± 1.05
2.817IleLeu: 2.817 ± 1.256
0.704IleMet: 0.704 ± 0.665
1.408IleAsn: 1.408 ± 0.787
2.817IlePro: 2.817 ± 1.332
0.0IleGln: 0.0 ± 0.0
5.634IleArg: 5.634 ± 1.861
3.521IleSer: 3.521 ± 1.489
4.225IleThr: 4.225 ± 0.747
5.634IleVal: 5.634 ± 1.136
0.704IleTrp: 0.704 ± 0.749
3.521IleTyr: 3.521 ± 1.502
0.0IleXaa: 0.0 ± 0.0
Lys
4.93LysAla: 4.93 ± 1.455
0.0LysCys: 0.0 ± 0.0
6.338LysAsp: 6.338 ± 2.384
2.113LysGlu: 2.113 ± 1.114
2.817LysPhe: 2.817 ± 1.578
2.817LysGly: 2.817 ± 1.094
1.408LysHis: 1.408 ± 0.666
2.113LysIle: 2.113 ± 1.245
1.408LysLys: 1.408 ± 1.696
6.338LysLeu: 6.338 ± 1.957
1.408LysMet: 1.408 ± 0.848
4.225LysAsn: 4.225 ± 0.937
4.93LysPro: 4.93 ± 1.697
0.704LysGln: 0.704 ± 0.614
4.93LysArg: 4.93 ± 2.567
3.521LysSer: 3.521 ± 0.668
2.113LysThr: 2.113 ± 1.114
5.634LysVal: 5.634 ± 3.122
0.0LysTrp: 0.0 ± 0.0
1.408LysTyr: 1.408 ± 0.688
0.0LysXaa: 0.0 ± 0.0
Leu
2.113LeuAla: 2.113 ± 0.653
0.704LeuCys: 0.704 ± 0.588
6.338LeuAsp: 6.338 ± 2.502
1.408LeuGlu: 1.408 ± 0.85
2.817LeuPhe: 2.817 ± 1.698
4.225LeuGly: 4.225 ± 1.083
3.521LeuHis: 3.521 ± 1.69
0.704LeuIle: 0.704 ± 0.588
7.746LeuLys: 7.746 ± 1.381
2.817LeuLeu: 2.817 ± 1.208
0.704LeuMet: 0.704 ± 0.628
3.521LeuAsn: 3.521 ± 1.761
2.817LeuPro: 2.817 ± 2.008
3.521LeuGln: 3.521 ± 1.716
4.93LeuArg: 4.93 ± 1.223
7.746LeuSer: 7.746 ± 2.389
5.634LeuThr: 5.634 ± 1.806
4.93LeuVal: 4.93 ± 1.54
0.0LeuTrp: 0.0 ± 0.0
3.521LeuTyr: 3.521 ± 1.484
0.0LeuXaa: 0.0 ± 0.0
Met
2.113MetAla: 2.113 ± 1.417
1.408MetCys: 1.408 ± 0.988
2.113MetAsp: 2.113 ± 1.509
0.0MetGlu: 0.0 ± 0.0
1.408MetPhe: 1.408 ± 1.329
0.704MetGly: 0.704 ± 0.628
0.704MetHis: 0.704 ± 0.665
0.0MetIle: 0.0 ± 0.0
1.408MetLys: 1.408 ± 0.791
0.704MetLeu: 0.704 ± 0.588
0.0MetMet: 0.0 ± 0.0
1.408MetAsn: 1.408 ± 0.787
1.408MetPro: 1.408 ± 0.688
0.704MetGln: 0.704 ± 0.588
0.704MetArg: 0.704 ± 0.848
2.817MetSer: 2.817 ± 1.583
0.704MetThr: 0.704 ± 0.614
1.408MetVal: 1.408 ± 1.255
0.704MetTrp: 0.704 ± 0.588
2.113MetTyr: 2.113 ± 1.03
0.0MetXaa: 0.0 ± 0.0
Asn
5.634AsnAla: 5.634 ± 2.265
2.113AsnCys: 2.113 ± 0.653
0.704AsnAsp: 0.704 ± 0.665
4.225AsnGlu: 4.225 ± 1.686
1.408AsnPhe: 1.408 ± 0.941
2.113AsnGly: 2.113 ± 1.509
4.225AsnHis: 4.225 ± 2.39
5.634AsnIle: 5.634 ± 1.598
0.704AsnLys: 0.704 ± 0.588
2.817AsnLeu: 2.817 ± 0.898
2.817AsnMet: 2.817 ± 1.382
2.113AsnAsn: 2.113 ± 0.907
2.113AsnPro: 2.113 ± 0.907
1.408AsnGln: 1.408 ± 1.255
4.225AsnArg: 4.225 ± 1.277
1.408AsnSer: 1.408 ± 0.787
2.817AsnThr: 2.817 ± 1.117
3.521AsnVal: 3.521 ± 1.728
1.408AsnTrp: 1.408 ± 1.175
2.817AsnTyr: 2.817 ± 0.904
0.0AsnXaa: 0.0 ± 0.0
Pro
0.0ProAla: 0.0 ± 0.0
0.704ProCys: 0.704 ± 0.665
3.521ProAsp: 3.521 ± 1.244
3.521ProGlu: 3.521 ± 1.844
0.704ProPhe: 0.704 ± 0.614
4.225ProGly: 4.225 ± 1.499
2.817ProHis: 2.817 ± 0.957
4.93ProIle: 4.93 ± 2.788
4.225ProLys: 4.225 ± 1.447
3.521ProLeu: 3.521 ± 2.076
1.408ProMet: 1.408 ± 1.329
1.408ProAsn: 1.408 ± 0.687
2.817ProPro: 2.817 ± 1.249
3.521ProGln: 3.521 ± 2.285
4.93ProArg: 4.93 ± 1.877
7.042ProSer: 7.042 ± 2.559
0.704ProThr: 0.704 ± 0.614
1.408ProVal: 1.408 ± 1.175
2.113ProTrp: 2.113 ± 0.611
2.113ProTyr: 2.113 ± 0.611
0.0ProXaa: 0.0 ± 0.0
Gln
4.225GlnAla: 4.225 ± 1.04
0.704GlnCys: 0.704 ± 0.588
1.408GlnAsp: 1.408 ± 1.696
3.521GlnGlu: 3.521 ± 1.397
1.408GlnPhe: 1.408 ± 1.227
0.0GlnGly: 0.0 ± 0.0
0.704GlnHis: 0.704 ± 0.848
1.408GlnIle: 1.408 ± 0.941
0.704GlnLys: 0.704 ± 0.588
5.634GlnLeu: 5.634 ± 2.994
0.704GlnMet: 0.704 ± 0.588
0.704GlnAsn: 0.704 ± 0.588
2.817GlnPro: 2.817 ± 2.008
0.704GlnGln: 0.704 ± 0.614
2.817GlnArg: 2.817 ± 1.798
3.521GlnSer: 3.521 ± 1.535
1.408GlnThr: 1.408 ± 0.687
2.113GlnVal: 2.113 ± 0.997
0.0GlnTrp: 0.0 ± 0.0
2.817GlnTyr: 2.817 ± 0.989
0.0GlnXaa: 0.0 ± 0.0
Arg
5.634ArgAla: 5.634 ± 2.006
1.408ArgCys: 1.408 ± 1.227
3.521ArgAsp: 3.521 ± 2.071
1.408ArgGlu: 1.408 ± 0.968
6.338ArgPhe: 6.338 ± 2.552
4.93ArgGly: 4.93 ± 2.028
2.817ArgHis: 2.817 ± 1.938
4.225ArgIle: 4.225 ± 2.037
2.817ArgLys: 2.817 ± 1.042
4.93ArgLeu: 4.93 ± 1.775
0.704ArgMet: 0.704 ± 0.614
2.113ArgAsn: 2.113 ± 1.763
3.521ArgPro: 3.521 ± 1.148
2.817ArgGln: 2.817 ± 1.044
8.451ArgArg: 8.451 ± 3.145
9.155ArgSer: 9.155 ± 0.636
4.225ArgThr: 4.225 ± 1.04
5.634ArgVal: 5.634 ± 0.974
0.704ArgTrp: 0.704 ± 0.614
1.408ArgTyr: 1.408 ± 0.871
0.0ArgXaa: 0.0 ± 0.0
Ser
4.225SerAla: 4.225 ± 1.998
1.408SerCys: 1.408 ± 0.791
4.225SerAsp: 4.225 ± 1.156
1.408SerGlu: 1.408 ± 0.787
4.93SerPhe: 4.93 ± 1.8
4.93SerGly: 4.93 ± 1.74
4.225SerHis: 4.225 ± 1.575
4.93SerIle: 4.93 ± 1.405
2.817SerLys: 2.817 ± 1.324
5.634SerLeu: 5.634 ± 1.798
2.113SerMet: 2.113 ± 0.89
5.634SerAsn: 5.634 ± 1.636
4.225SerPro: 4.225 ± 2.622
3.521SerGln: 3.521 ± 1.61
6.338SerArg: 6.338 ± 1.289
4.93SerSer: 4.93 ± 1.756
4.225SerThr: 4.225 ± 1.947
6.338SerVal: 6.338 ± 1.534
1.408SerTrp: 1.408 ± 0.666
4.93SerTyr: 4.93 ± 1.645
0.0SerXaa: 0.0 ± 0.0
Thr
4.93ThrAla: 4.93 ± 2.212
0.0ThrCys: 0.0 ± 0.0
0.704ThrAsp: 0.704 ± 0.614
2.817ThrGlu: 2.817 ± 1.256
2.817ThrPhe: 2.817 ± 0.957
2.817ThrGly: 2.817 ± 1.073
4.225ThrHis: 4.225 ± 1.651
1.408ThrIle: 1.408 ± 0.791
1.408ThrLys: 1.408 ± 1.175
3.521ThrLeu: 3.521 ± 1.265
2.113ThrMet: 2.113 ± 0.653
3.521ThrAsn: 3.521 ± 0.886
2.817ThrPro: 2.817 ± 0.989
0.0ThrGln: 0.0 ± 0.0
2.113ThrArg: 2.113 ± 1.623
4.93ThrSer: 4.93 ± 1.553
2.113ThrThr: 2.113 ± 1.596
4.93ThrVal: 4.93 ± 1.677
1.408ThrTrp: 1.408 ± 0.881
2.113ThrTyr: 2.113 ± 0.883
0.0ThrXaa: 0.0 ± 0.0
Val
4.225ValAla: 4.225 ± 1.492
0.0ValCys: 0.0 ± 0.0
4.225ValAsp: 4.225 ± 2.072
4.93ValGlu: 4.93 ± 1.541
2.817ValPhe: 2.817 ± 1.166
2.817ValGly: 2.817 ± 1.574
2.817ValHis: 2.817 ± 1.044
3.521ValIle: 3.521 ± 1.059
4.93ValLys: 4.93 ± 1.781
3.521ValLeu: 3.521 ± 1.055
2.113ValMet: 2.113 ± 1.994
2.817ValAsn: 2.817 ± 0.898
2.817ValPro: 2.817 ± 0.904
4.93ValGln: 4.93 ± 1.565
3.521ValArg: 3.521 ± 0.886
3.521ValSer: 3.521 ± 0.986
1.408ValThr: 1.408 ± 1.329
2.113ValVal: 2.113 ± 0.723
1.408ValTrp: 1.408 ± 0.988
6.338ValTyr: 6.338 ± 1.703
0.0ValXaa: 0.0 ± 0.0
Trp
2.113TrpAla: 2.113 ± 1.096
0.0TrpCys: 0.0 ± 0.0
0.0TrpAsp: 0.0 ± 0.0
1.408TrpGlu: 1.408 ± 0.881
0.0TrpPhe: 0.0 ± 0.0
0.0TrpGly: 0.0 ± 0.0
0.0TrpHis: 0.0 ± 0.0
0.0TrpIle: 0.0 ± 0.0
1.408TrpLys: 1.408 ± 0.666
0.704TrpLeu: 0.704 ± 0.665
1.408TrpMet: 1.408 ± 0.871
0.0TrpAsn: 0.0 ± 0.0
0.0TrpPro: 0.0 ± 0.0
0.704TrpGln: 0.704 ± 0.588
2.113TrpArg: 2.113 ± 1.434
1.408TrpSer: 1.408 ± 0.687
3.521TrpThr: 3.521 ± 1.743
1.408TrpVal: 1.408 ± 0.973
0.0TrpTrp: 0.0 ± 0.0
0.0TrpTyr: 0.0 ± 0.0
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.817TyrAla: 2.817 ± 2.034
1.408TyrCys: 1.408 ± 0.687
1.408TyrAsp: 1.408 ± 0.871
1.408TyrGlu: 1.408 ± 1.329
3.521TyrPhe: 3.521 ± 0.886
2.817TyrGly: 2.817 ± 0.528
0.704TyrHis: 0.704 ± 0.588
4.93TyrIle: 4.93 ± 0.867
1.408TyrLys: 1.408 ± 1.175
4.93TyrLeu: 4.93 ± 2.277
1.408TyrMet: 1.408 ± 0.972
2.817TyrAsn: 2.817 ± 0.528
2.817TyrPro: 2.817 ± 1.757
1.408TyrGln: 1.408 ± 0.666
5.634TyrArg: 5.634 ± 1.899
1.408TyrSer: 1.408 ± 0.688
1.408TyrThr: 1.408 ± 1.497
1.408TyrVal: 1.408 ± 0.85
0.0TyrTrp: 0.0 ± 0.0
1.408TyrTyr: 1.408 ± 0.791
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 6 proteins (1421 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski