Amino acid dipepetide frequency for Myceligenerans xiligouense

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	21.566AlaAla: 21.566 ± 0.238	0.857AlaCys: 0.857 ± 0.026	8.946AlaAsp: 8.946 ± 0.09	8.695AlaGlu: 8.695 ± 0.098	3.379AlaPhe: 3.379 ± 0.05	14.62AlaGly: 14.62 ± 0.123	2.612AlaHis: 2.612 ± 0.049	3.985AlaIle: 3.985 ± 0.06	2.144AlaLys: 2.144 ± 0.05	13.27AlaLeu: 13.27 ± 0.147	2.609AlaMet: 2.609 ± 0.049	1.95AlaAsn: 1.95 ± 0.04	7.297AlaPro: 7.297 ± 0.098	3.436AlaGln: 3.436 ± 0.062	10.781AlaArg: 10.781 ± 0.128	6.399AlaSer: 6.399 ± 0.075	8.133AlaThr: 8.133 ± 0.083	12.547AlaVal: 12.547 ± 0.118	2.158AlaTrp: 2.158 ± 0.037	2.306AlaTyr: 2.306 ± 0.039	0.0AlaXaa: 0.0 ± 0.0
Cys	0.724CysAla: 0.724 ± 0.02	0.053CysCys: 0.053 ± 0.007	0.381CysAsp: 0.381 ± 0.016	0.332CysGlu: 0.332 ± 0.015	0.173CysPhe: 0.173 ± 0.011	0.678CysGly: 0.678 ± 0.027	0.147CysHis: 0.147 ± 0.01	0.135CysIle: 0.135 ± 0.008	0.065CysLys: 0.065 ± 0.007	0.558CysLeu: 0.558 ± 0.02	0.084CysMet: 0.084 ± 0.008	0.124CysAsn: 0.124 ± 0.01	0.361CysPro: 0.361 ± 0.018	0.127CysGln: 0.127 ± 0.01	0.425CysArg: 0.425 ± 0.02	0.347CysSer: 0.347 ± 0.017	0.408CysThr: 0.408 ± 0.02	0.489CysVal: 0.489 ± 0.019	0.112CysTrp: 0.112 ± 0.01	0.134CysTyr: 0.134 ± 0.009	0.0CysXaa: 0.0 ± 0.0
Asp	8.872AspAla: 8.872 ± 0.09	0.316AspCys: 0.316 ± 0.017	5.258AspAsp: 5.258 ± 0.074	4.317AspGlu: 4.317 ± 0.057	1.431AspPhe: 1.431 ± 0.035	7.765AspGly: 7.765 ± 0.09	1.509AspHis: 1.509 ± 0.03	1.873AspIle: 1.873 ± 0.043	0.881AspLys: 0.881 ± 0.029	6.907AspLeu: 6.907 ± 0.068	0.815AspMet: 0.815 ± 0.023	0.89AspAsn: 0.89 ± 0.026	4.886AspPro: 4.886 ± 0.068	1.688AspGln: 1.688 ± 0.035	4.694AspArg: 4.694 ± 0.062	2.337AspSer: 2.337 ± 0.04	3.293AspThr: 3.293 ± 0.051	6.562AspVal: 6.562 ± 0.066	1.011AspTrp: 1.011 ± 0.033	1.185AspTyr: 1.185 ± 0.03	0.0AspXaa: 0.0 ± 0.0
Glu	7.601GluAla: 7.601 ± 0.085	0.315GluCys: 0.315 ± 0.018	3.05GluAsp: 3.05 ± 0.052	3.124GluGlu: 3.124 ± 0.051	1.509GluPhe: 1.509 ± 0.03	4.195GluGly: 4.195 ± 0.055	1.697GluHis: 1.697 ± 0.035	2.522GluIle: 2.522 ± 0.042	1.239GluLys: 1.239 ± 0.034	6.185GluLeu: 6.185 ± 0.085	0.932GluMet: 0.932 ± 0.026	1.2GluAsn: 1.2 ± 0.032	3.923GluPro: 3.923 ± 0.06	2.016GluGln: 2.016 ± 0.04	5.452GluArg: 5.452 ± 0.075	2.724GluSer: 2.724 ± 0.047	3.17GluThr: 3.17 ± 0.06	4.94GluVal: 4.94 ± 0.06	0.82GluTrp: 0.82 ± 0.026	1.202GluTyr: 1.202 ± 0.034	0.0GluXaa: 0.0 ± 0.0
Phe	3.6PheAla: 3.6 ± 0.043	0.184PheCys: 0.184 ± 0.013	2.062PheAsp: 2.062 ± 0.042	1.593PheGlu: 1.593 ± 0.038	0.807PhePhe: 0.807 ± 0.026	2.9PheGly: 2.9 ± 0.051	0.55PheHis: 0.55 ± 0.019	0.648PheIle: 0.648 ± 0.024	0.365PheLys: 0.365 ± 0.016	2.517PheLeu: 2.517 ± 0.048	0.388PheMet: 0.388 ± 0.015	0.474PheAsn: 0.474 ± 0.018	1.306PhePro: 1.306 ± 0.027	0.628PheGln: 0.628 ± 0.019	1.69PheArg: 1.69 ± 0.04	1.401PheSer: 1.401 ± 0.035	1.868PheThr: 1.868 ± 0.038	2.398PheVal: 2.398 ± 0.046	0.5PheTrp: 0.5 ± 0.02	0.55PheTyr: 0.55 ± 0.022	0.0PheXaa: 0.0 ± 0.0
Gly	12.152GlyAla: 12.152 ± 0.117	0.625GlyCys: 0.625 ± 0.021	5.974GlyAsp: 5.974 ± 0.075	5.572GlyGlu: 5.572 ± 0.066	2.896GlyPhe: 2.896 ± 0.043	8.989GlyGly: 8.989 ± 0.099	2.116GlyHis: 2.116 ± 0.041	3.611GlyIle: 3.611 ± 0.06	1.984GlyLys: 1.984 ± 0.045	9.206GlyLeu: 9.206 ± 0.091	2.086GlyMet: 2.086 ± 0.035	1.815GlyAsn: 1.815 ± 0.047	5.245GlyPro: 5.245 ± 0.078	2.571GlyGln: 2.571 ± 0.048	7.378GlyArg: 7.378 ± 0.086	5.6GlySer: 5.6 ± 0.063	6.916GlyThr: 6.916 ± 0.087	8.246GlyVal: 8.246 ± 0.093	1.81GlyTrp: 1.81 ± 0.037	2.222GlyTyr: 2.222 ± 0.041	0.0GlyXaa: 0.0 ± 0.0
His	2.633HisAla: 2.633 ± 0.042	0.13HisCys: 0.13 ± 0.01	1.648HisAsp: 1.648 ± 0.034	1.284HisGlu: 1.284 ± 0.032	0.521HisPhe: 0.521 ± 0.019	2.239HisGly: 2.239 ± 0.041	0.643HisHis: 0.643 ± 0.023	0.504HisIle: 0.504 ± 0.02	0.263HisLys: 0.263 ± 0.015	2.368HisLeu: 2.368 ± 0.044	0.291HisMet: 0.291 ± 0.014	0.335HisAsn: 0.335 ± 0.018	1.534HisPro: 1.534 ± 0.033	0.518HisGln: 0.518 ± 0.02	1.803HisArg: 1.803 ± 0.041	0.89HisSer: 0.89 ± 0.026	1.167HisThr: 1.167 ± 0.027	1.972HisVal: 1.972 ± 0.042	0.323HisTrp: 0.323 ± 0.017	0.403HisTyr: 0.403 ± 0.017	0.0HisXaa: 0.0 ± 0.0
Ile	4.904IleAla: 4.904 ± 0.064	0.216IleCys: 0.216 ± 0.011	2.621IleAsp: 2.621 ± 0.053	2.097IleGlu: 2.097 ± 0.042	0.746IlePhe: 0.746 ± 0.03	3.391IleGly: 3.391 ± 0.058	0.561IleHis: 0.561 ± 0.02	0.947IleIle: 0.947 ± 0.033	0.567IleLys: 0.567 ± 0.021	2.663IleLeu: 2.663 ± 0.056	0.476IleMet: 0.476 ± 0.02	0.607IleAsn: 0.607 ± 0.021	1.824IlePro: 1.824 ± 0.044	0.722IleGln: 0.722 ± 0.023	2.13IleArg: 2.13 ± 0.04	1.647IleSer: 1.647 ± 0.034	2.286IleThr: 2.286 ± 0.045	3.11IleVal: 3.11 ± 0.051	0.378IleTrp: 0.378 ± 0.016	0.531IleTyr: 0.531 ± 0.021	0.0IleXaa: 0.0 ± 0.0
Lys	2.095LysAla: 2.095 ± 0.051	0.085LysCys: 0.085 ± 0.01	1.003LysAsp: 1.003 ± 0.034	0.908LysGlu: 0.908 ± 0.033	0.403LysPhe: 0.403 ± 0.017	1.273LysGly: 1.273 ± 0.036	0.442LysHis: 0.442 ± 0.018	0.707LysIle: 0.707 ± 0.025	0.576LysLys: 0.576 ± 0.028	1.493LysLeu: 1.493 ± 0.037	0.297LysMet: 0.297 ± 0.016	0.425LysAsn: 0.425 ± 0.018	1.03LysPro: 1.03 ± 0.035	0.572LysGln: 0.572 ± 0.023	1.203LysArg: 1.203 ± 0.033	0.907LysSer: 0.907 ± 0.027	0.986LysThr: 0.986 ± 0.032	1.497LysVal: 1.497 ± 0.035	0.212LysTrp: 0.212 ± 0.011	0.379LysTyr: 0.379 ± 0.017	0.0LysXaa: 0.0 ± 0.0
Leu	15.02LeuAla: 15.02 ± 0.155	0.573LeuCys: 0.573 ± 0.02	7.057LeuAsp: 7.057 ± 0.073	4.82LeuGlu: 4.82 ± 0.069	2.325LeuPhe: 2.325 ± 0.045	9.184LeuGly: 9.184 ± 0.092	1.934LeuHis: 1.934 ± 0.041	2.821LeuIle: 2.821 ± 0.056	1.359LeuLys: 1.359 ± 0.037	9.839LeuLeu: 9.839 ± 0.117	1.446LeuMet: 1.446 ± 0.034	1.543LeuAsn: 1.543 ± 0.038	5.691LeuPro: 5.691 ± 0.077	1.954LeuGln: 1.954 ± 0.039	8.008LeuArg: 8.008 ± 0.095	4.873LeuSer: 4.873 ± 0.06	6.519LeuThr: 6.519 ± 0.076	9.589LeuVal: 9.589 ± 0.113	1.205LeuTrp: 1.205 ± 0.031	1.501LeuTyr: 1.501 ± 0.035	0.0LeuXaa: 0.0 ± 0.0
Met	2.064MetAla: 2.064 ± 0.048	0.108MetCys: 0.108 ± 0.009	0.833MetAsp: 0.833 ± 0.026	0.717MetGlu: 0.717 ± 0.025	0.531MetPhe: 0.531 ± 0.02	1.227MetGly: 1.227 ± 0.037	0.358MetHis: 0.358 ± 0.016	0.689MetIle: 0.689 ± 0.023	0.354MetLys: 0.354 ± 0.017	1.789MetLeu: 1.789 ± 0.041	0.282MetMet: 0.282 ± 0.015	0.477MetAsn: 0.477 ± 0.018	1.111MetPro: 1.111 ± 0.025	0.401MetGln: 0.401 ± 0.017	1.436MetArg: 1.436 ± 0.034	1.375MetSer: 1.375 ± 0.034	1.703MetThr: 1.703 ± 0.035	1.337MetVal: 1.337 ± 0.033	0.209MetTrp: 0.209 ± 0.013	0.276MetTyr: 0.276 ± 0.013	0.0MetXaa: 0.0 ± 0.0
Asn	2.14AsnAla: 2.14 ± 0.038	0.11AsnCys: 0.11 ± 0.009	1.087AsnAsp: 1.087 ± 0.03	0.844AsnGlu: 0.844 ± 0.026	0.481AsnPhe: 0.481 ± 0.021	1.891AsnGly: 1.891 ± 0.049	0.403AsnHis: 0.403 ± 0.018	0.633AsnIle: 0.633 ± 0.026	0.31AsnLys: 0.31 ± 0.015	1.794AsnLeu: 1.794 ± 0.039	0.283AsnMet: 0.283 ± 0.015	0.437AsnAsn: 0.437 ± 0.022	1.366AsnPro: 1.366 ± 0.036	0.513AsnGln: 0.513 ± 0.021	1.212AsnArg: 1.212 ± 0.034	0.842AsnSer: 0.842 ± 0.026	1.042AsnThr: 1.042 ± 0.027	1.481AsnVal: 1.481 ± 0.035	0.278AsnTrp: 0.278 ± 0.016	0.427AsnTyr: 0.427 ± 0.018	0.0AsnXaa: 0.0 ± 0.0
Pro	8.841ProAla: 8.841 ± 0.115	0.237ProCys: 0.237 ± 0.012	4.945ProAsp: 4.945 ± 0.07	4.337ProGlu: 4.337 ± 0.062	1.491ProPhe: 1.491 ± 0.033	7.116ProGly: 7.116 ± 0.088	1.241ProHis: 1.241 ± 0.033	1.41ProIle: 1.41 ± 0.035	0.768ProLys: 0.768 ± 0.027	4.725ProLeu: 4.725 ± 0.057	0.926ProMet: 0.926 ± 0.025	0.875ProAsn: 0.875 ± 0.024	3.163ProPro: 3.163 ± 0.069	1.468ProGln: 1.468 ± 0.043	3.896ProArg: 3.896 ± 0.054	3.447ProSer: 3.447 ± 0.061	3.348ProThr: 3.348 ± 0.061	5.525ProVal: 5.525 ± 0.065	0.912ProTrp: 0.912 ± 0.025	1.131ProTyr: 1.131 ± 0.032	0.0ProXaa: 0.0 ± 0.0
Gln	3.456GlnAla: 3.456 ± 0.056	0.124GlnCys: 0.124 ± 0.01	1.458GlnAsp: 1.458 ± 0.035	1.401GlnGlu: 1.401 ± 0.031	0.718GlnPhe: 0.718 ± 0.026	2.031GlnGly: 2.031 ± 0.04	0.594GlnHis: 0.594 ± 0.024	1.111GlnIle: 1.111 ± 0.028	0.435GlnLys: 0.435 ± 0.019	2.342GlnLeu: 2.342 ± 0.049	0.482GlnMet: 0.482 ± 0.02	0.548GlnAsn: 0.548 ± 0.022	1.447GlnPro: 1.447 ± 0.042	0.999GlnGln: 0.999 ± 0.032	2.068GlnArg: 2.068 ± 0.039	1.143GlnSer: 1.143 ± 0.029	1.234GlnThr: 1.234 ± 0.033	2.811GlnVal: 2.811 ± 0.049	0.456GlnTrp: 0.456 ± 0.022	0.587GlnTyr: 0.587 ± 0.023	0.0GlnXaa: 0.0 ± 0.0
Arg	9.996ArgAla: 9.996 ± 0.115	0.424ArgCys: 0.424 ± 0.02	4.723ArgAsp: 4.723 ± 0.061	4.653ArgGlu: 4.653 ± 0.071	2.174ArgPhe: 2.174 ± 0.041	6.013ArgGly: 6.013 ± 0.069	1.826ArgHis: 1.826 ± 0.036	2.994ArgIle: 2.994 ± 0.047	1.433ArgLys: 1.433 ± 0.036	7.765ArgLeu: 7.765 ± 0.094	1.66ArgMet: 1.66 ± 0.036	1.325ArgAsn: 1.325 ± 0.033	4.654ArgPro: 4.654 ± 0.061	2.047ArgGln: 2.047 ± 0.04	7.494ArgArg: 7.494 ± 0.109	4.157ArgSer: 4.157 ± 0.057	5.204ArgThr: 5.204 ± 0.073	6.288ArgVal: 6.288 ± 0.066	1.44ArgTrp: 1.44 ± 0.034	1.716ArgTyr: 1.716 ± 0.038	0.0ArgXaa: 0.0 ± 0.0
Ser	6.79SerAla: 6.79 ± 0.087	0.306SerCys: 0.306 ± 0.017	3.224SerAsp: 3.224 ± 0.053	2.556SerGlu: 2.556 ± 0.048	1.492SerPhe: 1.492 ± 0.034	6.297SerGly: 6.297 ± 0.079	0.972SerHis: 0.972 ± 0.026	1.533SerIle: 1.533 ± 0.035	0.789SerLys: 0.789 ± 0.029	4.538SerLeu: 4.538 ± 0.055	1.065SerMet: 1.065 ± 0.029	0.959SerAsn: 0.959 ± 0.027	3.16SerPro: 3.16 ± 0.052	1.186SerGln: 1.186 ± 0.028	3.791SerArg: 3.791 ± 0.054	3.055SerSer: 3.055 ± 0.048	3.245SerThr: 3.245 ± 0.047	4.271SerVal: 4.271 ± 0.051	0.977SerTrp: 0.977 ± 0.027	1.126SerTyr: 1.126 ± 0.031	0.0SerXaa: 0.0 ± 0.0
Thr	8.479ThrAla: 8.479 ± 0.097	0.396ThrCys: 0.396 ± 0.02	3.927ThrAsp: 3.927 ± 0.065	3.395ThrGlu: 3.395 ± 0.06	1.903ThrPhe: 1.903 ± 0.038	6.816ThrGly: 6.816 ± 0.073	1.212ThrHis: 1.212 ± 0.03	2.231ThrIle: 2.231 ± 0.038	0.972ThrLys: 0.972 ± 0.03	5.799ThrLeu: 5.799 ± 0.071	1.077ThrMet: 1.077 ± 0.03	1.094ThrAsn: 1.094 ± 0.029	4.35ThrPro: 4.35 ± 0.066	1.435ThrGln: 1.435 ± 0.038	4.312ThrArg: 4.312 ± 0.06	3.561ThrSer: 3.561 ± 0.052	4.58ThrThr: 4.58 ± 0.079	6.063ThrVal: 6.063 ± 0.078	1.106ThrTrp: 1.106 ± 0.03	1.383ThrTyr: 1.383 ± 0.045	0.0ThrXaa: 0.0 ± 0.0
Val	12.644ValAla: 12.644 ± 0.118	0.556ValCys: 0.556 ± 0.017	5.856ValAsp: 5.856 ± 0.068	5.208ValGlu: 5.208 ± 0.064	2.303ValPhe: 2.303 ± 0.043	7.366ValGly: 7.366 ± 0.086	1.868ValHis: 1.868 ± 0.036	2.98ValIle: 2.98 ± 0.048	1.378ValLys: 1.378 ± 0.039	9.834ValLeu: 9.834 ± 0.103	1.511ValMet: 1.511 ± 0.036	1.626ValAsn: 1.626 ± 0.035	5.627ValPro: 5.627 ± 0.075	2.041ValGln: 2.041 ± 0.04	7.286ValArg: 7.286 ± 0.074	4.624ValSer: 4.624 ± 0.063	6.614ValThr: 6.614 ± 0.077	10.329ValVal: 10.329 ± 0.112	1.232ValTrp: 1.232 ± 0.032	1.451ValTyr: 1.451 ± 0.038	0.0ValXaa: 0.0 ± 0.0
Trp	1.757TrpAla: 1.757 ± 0.037	0.11TrpCys: 0.11 ± 0.009	0.939TrpAsp: 0.939 ± 0.03	0.795TrpGlu: 0.795 ± 0.022	0.575TrpPhe: 0.575 ± 0.021	1.107TrpGly: 1.107 ± 0.027	0.396TrpHis: 0.396 ± 0.017	0.629TrpIle: 0.629 ± 0.023	0.312TrpLys: 0.312 ± 0.015	1.703TrpLeu: 1.703 ± 0.037	0.331TrpMet: 0.331 ± 0.016	0.48TrpAsn: 0.48 ± 0.023	0.803TrpPro: 0.803 ± 0.025	0.527TrpGln: 0.527 ± 0.021	1.318TrpArg: 1.318 ± 0.03	1.045TrpSer: 1.045 ± 0.027	1.158TrpThr: 1.158 ± 0.029	1.162TrpVal: 1.162 ± 0.032	0.412TrpTrp: 0.412 ± 0.019	0.352TrpTyr: 0.352 ± 0.016	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.357TyrAla: 2.357 ± 0.042	0.131TyrCys: 0.131 ± 0.011	1.5TyrAsp: 1.5 ± 0.045	1.168TyrGlu: 1.168 ± 0.034	0.572TyrPhe: 0.572 ± 0.022	1.914TyrGly: 1.914 ± 0.041	0.39TyrHis: 0.39 ± 0.016	0.46TyrIle: 0.46 ± 0.019	0.298TyrLys: 0.298 ± 0.016	1.964TyrLeu: 1.964 ± 0.039	0.234TyrMet: 0.234 ± 0.015	0.391TyrAsn: 0.391 ± 0.02	1.023TyrPro: 1.023 ± 0.028	0.599TyrGln: 0.599 ± 0.026	1.607TyrArg: 1.607 ± 0.037	0.958TyrSer: 0.958 ± 0.027	1.217TyrThr: 1.217 ± 0.035	1.715TyrVal: 1.715 ± 0.04	0.364TyrTrp: 0.364 ± 0.016	0.457TyrTyr: 0.457 ± 0.019	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3975 proteins (1408027 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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