Amino acid dipepetide frequency for Dufourea novaeangliae (Sweat bee)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	5.237AlaAla: 5.237 ± 0.057	1.198AlaCys: 1.198 ± 0.041	2.898AlaAsp: 2.898 ± 0.026	3.952AlaGlu: 3.952 ± 0.036	2.103AlaPhe: 2.103 ± 0.026	3.565AlaGly: 3.565 ± 0.034	1.328AlaHis: 1.328 ± 0.019	3.391AlaIle: 3.391 ± 0.028	3.578AlaLys: 3.578 ± 0.042	5.597AlaLeu: 5.597 ± 0.052	1.467AlaMet: 1.467 ± 0.019	2.614AlaAsn: 2.614 ± 0.027	2.779AlaPro: 2.779 ± 0.034	2.316AlaGln: 2.316 ± 0.026	3.458AlaArg: 3.458 ± 0.031	4.819AlaSer: 4.819 ± 0.034	3.977AlaThr: 3.977 ± 0.031	4.108AlaVal: 4.108 ± 0.034	0.642AlaTrp: 0.642 ± 0.014	1.598AlaTyr: 1.598 ± 0.02	0.001AlaXaa: 0.001 ± 0.0
Cys	1.094CysAla: 1.094 ± 0.023	0.492CysCys: 0.492 ± 0.013	1.073CysAsp: 1.073 ± 0.019	1.121CysGlu: 1.121 ± 0.026	0.731CysPhe: 0.731 ± 0.013	1.361CysGly: 1.361 ± 0.06	0.514CysHis: 0.514 ± 0.013	1.163CysIle: 1.163 ± 0.036	1.148CysLys: 1.148 ± 0.02	1.833CysLeu: 1.833 ± 0.034	0.456CysMet: 0.456 ± 0.014	0.995CysAsn: 0.995 ± 0.022	1.104CysPro: 1.104 ± 0.054	0.785CysGln: 0.785 ± 0.03	1.206CysArg: 1.206 ± 0.06	1.665CysSer: 1.665 ± 0.05	1.203CysThr: 1.203 ± 0.04	1.279CysVal: 1.279 ± 0.049	0.234CysTrp: 0.234 ± 0.006	0.612CysTyr: 0.612 ± 0.012	0.0CysXaa: 0.0 ± 0.0
Asp	3.043AspAla: 3.043 ± 0.028	1.041AspCys: 1.041 ± 0.031	3.556AspAsp: 3.556 ± 0.047	4.167AspGlu: 4.167 ± 0.039	2.022AspPhe: 2.022 ± 0.021	3.22AspGly: 3.22 ± 0.034	1.184AspHis: 1.184 ± 0.019	3.41AspIle: 3.41 ± 0.033	3.142AspLys: 3.142 ± 0.035	4.781AspLeu: 4.781 ± 0.037	1.206AspMet: 1.206 ± 0.019	2.542AspAsn: 2.542 ± 0.028	2.563AspPro: 2.563 ± 0.056	1.783AspGln: 1.783 ± 0.02	2.964AspArg: 2.964 ± 0.034	4.362AspSer: 4.362 ± 0.042	3.217AspThr: 3.217 ± 0.026	3.648AspVal: 3.648 ± 0.033	0.618AspTrp: 0.618 ± 0.011	1.787AspTyr: 1.787 ± 0.019	0.0AspXaa: 0.0 ± 0.0
Glu	4.08GluAla: 4.08 ± 0.036	1.287GluCys: 1.287 ± 0.059	4.324GluAsp: 4.324 ± 0.039	6.568GluGlu: 6.568 ± 0.104	2.118GluPhe: 2.118 ± 0.024	3.205GluGly: 3.205 ± 0.037	1.526GluHis: 1.526 ± 0.018	3.98GluIle: 3.98 ± 0.038	5.376GluLys: 5.376 ± 0.066	5.81GluLeu: 5.81 ± 0.053	1.565GluMet: 1.565 ± 0.02	3.91GluAsn: 3.91 ± 0.034	2.653GluPro: 2.653 ± 0.034	2.811GluGln: 2.811 ± 0.034	4.078GluArg: 4.078 ± 0.04	4.772GluSer: 4.772 ± 0.046	4.143GluThr: 4.143 ± 0.047	3.917GluVal: 3.917 ± 0.052	0.696GluTrp: 0.696 ± 0.011	1.974GluTyr: 1.974 ± 0.017	0.0GluXaa: 0.0 ± 0.0
Phe	1.992PheAla: 1.992 ± 0.024	0.772PheCys: 0.772 ± 0.013	1.967PheAsp: 1.967 ± 0.024	2.14PheGlu: 2.14 ± 0.022	1.399PhePhe: 1.399 ± 0.022	2.18PheGly: 2.18 ± 0.028	0.971PheHis: 0.971 ± 0.014	1.871PheIle: 1.871 ± 0.024	1.936PheLys: 1.936 ± 0.024	3.43PheLeu: 3.43 ± 0.032	0.774PheMet: 0.774 ± 0.014	1.629PheAsn: 1.629 ± 0.02	1.662PhePro: 1.662 ± 0.02	1.397PheGln: 1.397 ± 0.017	1.879PheArg: 1.879 ± 0.023	2.717PheSer: 2.717 ± 0.028	2.063PheThr: 2.063 ± 0.021	2.36PheVal: 2.36 ± 0.023	0.424PheTrp: 0.424 ± 0.009	1.227PheTyr: 1.227 ± 0.019	0.0PheXaa: 0.0 ± 0.0
Gly	3.23GlyAla: 3.23 ± 0.034	1.097GlyCys: 1.097 ± 0.025	2.924GlyAsp: 2.924 ± 0.033	3.297GlyGlu: 3.297 ± 0.033	2.098GlyPhe: 2.098 ± 0.025	4.54GlyGly: 4.54 ± 0.077	1.482GlyHis: 1.482 ± 0.021	3.226GlyIle: 3.226 ± 0.036	3.598GlyLys: 3.598 ± 0.037	4.598GlyLeu: 4.598 ± 0.04	1.227GlyMet: 1.227 ± 0.017	2.88GlyAsn: 2.88 ± 0.031	2.615GlyPro: 2.615 ± 0.044	2.145GlyGln: 2.145 ± 0.026	3.288GlyArg: 3.288 ± 0.03	4.889GlySer: 4.889 ± 0.048	3.523GlyThr: 3.523 ± 0.039	3.446GlyVal: 3.446 ± 0.034	0.689GlyTrp: 0.689 ± 0.013	1.967GlyTyr: 1.967 ± 0.031	0.0GlyXaa: 0.0 ± 0.0
His	1.382HisAla: 1.382 ± 0.017	0.582HisCys: 0.582 ± 0.012	1.144HisAsp: 1.144 ± 0.016	1.423HisGlu: 1.423 ± 0.017	0.934HisPhe: 0.934 ± 0.015	1.489HisGly: 1.489 ± 0.02	1.108HisHis: 1.108 ± 0.031	1.369HisIle: 1.369 ± 0.024	1.304HisLys: 1.304 ± 0.018	2.293HisLeu: 2.293 ± 0.024	0.564HisMet: 0.564 ± 0.012	1.111HisAsn: 1.111 ± 0.015	1.413HisPro: 1.413 ± 0.022	1.155HisGln: 1.155 ± 0.02	1.592HisArg: 1.592 ± 0.02	1.959HisSer: 1.959 ± 0.024	1.405HisThr: 1.405 ± 0.016	1.609HisVal: 1.609 ± 0.018	0.3HisTrp: 0.3 ± 0.008	0.839HisTyr: 0.839 ± 0.014	0.0HisXaa: 0.0 ± 0.0
Ile	3.488IleAla: 3.488 ± 0.031	1.164IleCys: 1.164 ± 0.03	3.164IleAsp: 3.164 ± 0.029	3.815IleGlu: 3.815 ± 0.034	2.084IlePhe: 2.084 ± 0.028	3.04IleGly: 3.04 ± 0.039	1.386IleHis: 1.386 ± 0.029	3.128IleIle: 3.128 ± 0.034	3.38IleLys: 3.38 ± 0.035	5.301IleLeu: 5.301 ± 0.046	1.164IleMet: 1.164 ± 0.016	2.706IleAsn: 2.706 ± 0.03	2.948IlePro: 2.948 ± 0.028	2.264IleGln: 2.264 ± 0.024	2.925IleArg: 2.925 ± 0.026	4.285IleSer: 4.285 ± 0.029	3.286IleThr: 3.286 ± 0.032	3.652IleVal: 3.652 ± 0.029	0.571IleTrp: 0.571 ± 0.012	1.685IleTyr: 1.685 ± 0.022	0.0IleXaa: 0.0 ± 0.0
Lys	3.337LysAla: 3.337 ± 0.038	1.225LysCys: 1.225 ± 0.037	3.598LysAsp: 3.598 ± 0.042	5.001LysGlu: 5.001 ± 0.059	2.031LysPhe: 2.031 ± 0.025	2.808LysGly: 2.808 ± 0.035	1.576LysHis: 1.576 ± 0.019	3.667LysIle: 3.667 ± 0.034	5.369LysLys: 5.369 ± 0.073	5.736LysLeu: 5.736 ± 0.045	1.492LysMet: 1.492 ± 0.018	3.191LysAsn: 3.191 ± 0.031	2.973LysPro: 2.973 ± 0.053	2.768LysGln: 2.768 ± 0.03	4.003LysArg: 4.003 ± 0.032	4.66LysSer: 4.66 ± 0.052	3.626LysThr: 3.626 ± 0.034	3.732LysVal: 3.732 ± 0.037	0.686LysTrp: 0.686 ± 0.013	2.102LysTyr: 2.102 ± 0.026	0.001LysXaa: 0.001 ± 0.0
Leu	5.726LeuAla: 5.726 ± 0.046	1.794LeuCys: 1.794 ± 0.025	4.75LeuAsp: 4.75 ± 0.037	6.268LeuGlu: 6.268 ± 0.053	3.032LeuPhe: 3.032 ± 0.033	4.583LeuGly: 4.583 ± 0.04	2.391LeuHis: 2.391 ± 0.025	4.454LeuIle: 4.454 ± 0.037	5.924LeuLys: 5.924 ± 0.052	8.614LeuLeu: 8.614 ± 0.07	1.97LeuMet: 1.97 ± 0.023	4.276LeuAsn: 4.276 ± 0.033	4.738LeuPro: 4.738 ± 0.033	4.456LeuGln: 4.456 ± 0.043	5.394LeuArg: 5.394 ± 0.043	6.984LeuSer: 6.984 ± 0.047	5.098LeuThr: 5.098 ± 0.035	5.083LeuVal: 5.083 ± 0.044	0.958LeuTrp: 0.958 ± 0.016	2.744LeuTyr: 2.744 ± 0.03	0.001LeuXaa: 0.001 ± 0.0
Met	1.511MetAla: 1.511 ± 0.022	0.437MetCys: 0.437 ± 0.009	1.325MetAsp: 1.325 ± 0.017	1.687MetGlu: 1.687 ± 0.019	0.827MetPhe: 0.827 ± 0.016	1.16MetGly: 1.16 ± 0.021	0.536MetHis: 0.536 ± 0.011	1.168MetIle: 1.168 ± 0.018	1.57MetLys: 1.57 ± 0.019	1.967MetLeu: 1.967 ± 0.026	0.589MetMet: 0.589 ± 0.013	1.116MetAsn: 1.116 ± 0.015	1.059MetPro: 1.059 ± 0.016	1.009MetGln: 1.009 ± 0.017	1.17MetArg: 1.17 ± 0.015	1.73MetSer: 1.73 ± 0.018	1.249MetThr: 1.249 ± 0.015	1.294MetVal: 1.294 ± 0.016	0.253MetTrp: 0.253 ± 0.007	0.752MetTyr: 0.752 ± 0.015	0.0MetXaa: 0.0 ± 0.0
Asn	2.886AsnAla: 2.886 ± 0.036	0.948AsnCys: 0.948 ± 0.022	2.752AsnAsp: 2.752 ± 0.03	3.389AsnGlu: 3.389 ± 0.031	1.758AsnPhe: 1.758 ± 0.022	3.02AsnGly: 3.02 ± 0.036	1.174AsnHis: 1.174 ± 0.025	3.169AsnIle: 3.169 ± 0.031	3.015AsnLys: 3.015 ± 0.032	4.312AsnLeu: 4.312 ± 0.038	1.135AsnMet: 1.135 ± 0.016	2.999AsnAsn: 2.999 ± 0.037	2.3AsnPro: 2.3 ± 0.042	1.829AsnGln: 1.829 ± 0.022	2.513AsnArg: 2.513 ± 0.024	3.946AsnSer: 3.946 ± 0.036	3.022AsnThr: 3.022 ± 0.032	3.543AsnVal: 3.543 ± 0.03	0.505AsnTrp: 0.505 ± 0.009	1.586AsnTyr: 1.586 ± 0.022	0.0AsnXaa: 0.0 ± 0.0
Pro	3.175ProAla: 3.175 ± 0.033	0.904ProCys: 0.904 ± 0.078	2.588ProAsp: 2.588 ± 0.025	3.466ProGlu: 3.466 ± 0.054	1.603ProPhe: 1.603 ± 0.024	3.196ProGly: 3.196 ± 0.077	1.224ProHis: 1.224 ± 0.02	2.592ProIle: 2.592 ± 0.024	2.784ProLys: 2.784 ± 0.038	4.189ProLeu: 4.189 ± 0.029	1.049ProMet: 1.049 ± 0.015	2.306ProAsn: 2.306 ± 0.034	4.456ProPro: 4.456 ± 0.071	2.137ProGln: 2.137 ± 0.027	2.93ProArg: 2.93 ± 0.028	4.455ProSer: 4.455 ± 0.049	3.344ProThr: 3.344 ± 0.035	3.422ProVal: 3.422 ± 0.044	0.54ProTrp: 0.54 ± 0.011	1.521ProTyr: 1.521 ± 0.023	0.0ProXaa: 0.0 ± 0.0
Gln	2.427GlnAla: 2.427 ± 0.029	0.805GlnCys: 0.805 ± 0.029	1.988GlnAsp: 1.988 ± 0.02	3.001GlnGlu: 3.001 ± 0.033	1.344GlnPhe: 1.344 ± 0.015	1.978GlnGly: 1.978 ± 0.026	1.199GlnHis: 1.199 ± 0.017	2.197GlnIle: 2.197 ± 0.022	2.64GlnLys: 2.64 ± 0.029	3.915GlnLeu: 3.915 ± 0.04	0.98GlnMet: 0.98 ± 0.016	2.215GlnAsn: 2.215 ± 0.028	2.147GlnPro: 2.147 ± 0.032	3.442GlnGln: 3.442 ± 0.089	2.589GlnArg: 2.589 ± 0.023	3.063GlnSer: 3.063 ± 0.03	2.469GlnThr: 2.469 ± 0.026	2.348GlnVal: 2.348 ± 0.027	0.467GlnTrp: 0.467 ± 0.009	1.261GlnTyr: 1.261 ± 0.015	0.0GlnXaa: 0.0 ± 0.0
Arg	3.156ArgAla: 3.156 ± 0.027	1.177ArgCys: 1.177 ± 0.026	3.103ArgAsp: 3.103 ± 0.036	3.826ArgGlu: 3.826 ± 0.03	1.949ArgPhe: 1.949 ± 0.019	3.211ArgGly: 3.211 ± 0.034	1.606ArgHis: 1.606 ± 0.02	3.144ArgIle: 3.144 ± 0.027	4.103ArgLys: 4.103 ± 0.035	5.117ArgLeu: 5.117 ± 0.039	1.252ArgMet: 1.252 ± 0.017	2.964ArgAsn: 2.964 ± 0.026	2.787ArgPro: 2.787 ± 0.041	2.385ArgGln: 2.385 ± 0.022	4.626ArgArg: 4.626 ± 0.055	4.604ArgSer: 4.604 ± 0.049	3.153ArgThr: 3.153 ± 0.023	3.277ArgVal: 3.277 ± 0.027	0.646ArgTrp: 0.646 ± 0.013	1.803ArgTyr: 1.803 ± 0.022	0.0ArgXaa: 0.0 ± 0.0
Ser	4.442SerAla: 4.442 ± 0.031	1.547SerCys: 1.547 ± 0.054	4.235SerAsp: 4.235 ± 0.039	4.817SerGlu: 4.817 ± 0.038	2.672SerPhe: 2.672 ± 0.025	4.814SerGly: 4.814 ± 0.045	1.828SerHis: 1.828 ± 0.021	4.209SerIle: 4.209 ± 0.033	4.722SerLys: 4.722 ± 0.045	7.014SerLeu: 7.014 ± 0.051	1.775SerMet: 1.775 ± 0.019	4.185SerAsn: 4.185 ± 0.044	4.688SerPro: 4.688 ± 0.053	3.206SerGln: 3.206 ± 0.033	4.564SerArg: 4.564 ± 0.044	8.488SerSer: 8.488 ± 0.083	5.417SerThr: 5.417 ± 0.043	5.111SerVal: 5.111 ± 0.035	0.853SerTrp: 0.853 ± 0.014	2.228SerTyr: 2.228 ± 0.026	0.001SerXaa: 0.001 ± 0.0
Thr	3.913ThrAla: 3.913 ± 0.033	1.22ThrCys: 1.22 ± 0.037	3.159ThrAsp: 3.159 ± 0.024	4.173ThrGlu: 4.173 ± 0.067	2.086ThrPhe: 2.086 ± 0.027	3.627ThrGly: 3.627 ± 0.032	1.26ThrHis: 1.26 ± 0.017	3.451ThrIle: 3.451 ± 0.025	3.566ThrLys: 3.566 ± 0.029	5.314ThrLeu: 5.314 ± 0.038	1.377ThrMet: 1.377 ± 0.016	2.966ThrAsn: 2.966 ± 0.027	3.583ThrPro: 3.583 ± 0.045	2.216ThrGln: 2.216 ± 0.025	3.012ThrArg: 3.012 ± 0.029	5.25ThrSer: 5.25 ± 0.048	4.591ThrThr: 4.591 ± 0.088	4.307ThrVal: 4.307 ± 0.04	0.642ThrTrp: 0.642 ± 0.012	1.702ThrTyr: 1.702 ± 0.025	0.0ThrXaa: 0.0 ± 0.0
Val	4.175ValAla: 4.175 ± 0.036	1.429ValCys: 1.429 ± 0.039	3.452ValAsp: 3.452 ± 0.033	4.151ValGlu: 4.151 ± 0.052	2.255ValPhe: 2.255 ± 0.027	3.304ValGly: 3.304 ± 0.029	1.571ValHis: 1.571 ± 0.02	3.467ValIle: 3.467 ± 0.026	3.807ValLys: 3.807 ± 0.037	5.548ValLeu: 5.548 ± 0.038	1.368ValMet: 1.368 ± 0.016	2.999ValAsn: 2.999 ± 0.032	3.498ValPro: 3.498 ± 0.038	2.664ValGln: 2.664 ± 0.025	3.229ValArg: 3.229 ± 0.024	4.99ValSer: 4.99 ± 0.04	4.152ValThr: 4.152 ± 0.054	4.146ValVal: 4.146 ± 0.037	0.697ValTrp: 0.697 ± 0.013	1.911ValTyr: 1.911 ± 0.022	0.0ValXaa: 0.0 ± 0.0
Trp	0.591TrpAla: 0.591 ± 0.012	0.239TrpCys: 0.239 ± 0.007	0.593TrpAsp: 0.593 ± 0.012	0.64TrpGlu: 0.64 ± 0.012	0.443TrpPhe: 0.443 ± 0.01	0.58TrpGly: 0.58 ± 0.013	0.266TrpHis: 0.266 ± 0.007	0.673TrpIle: 0.673 ± 0.011	0.765TrpLys: 0.765 ± 0.015	1.075TrpLeu: 1.075 ± 0.018	0.282TrpMet: 0.282 ± 0.007	0.599TrpAsn: 0.599 ± 0.013	0.447TrpPro: 0.447 ± 0.011	0.446TrpGln: 0.446 ± 0.01	0.705TrpArg: 0.705 ± 0.012	0.87TrpSer: 0.87 ± 0.014	0.625TrpThr: 0.625 ± 0.012	0.577TrpVal: 0.577 ± 0.012	0.186TrpTrp: 0.186 ± 0.006	0.369TrpTyr: 0.369 ± 0.01	0.0TrpXaa: 0.0 ± 0.0
Tyr	1.74TyrAla: 1.74 ± 0.019	0.711TyrCys: 0.711 ± 0.014	1.666TyrAsp: 1.666 ± 0.021	1.893TyrGlu: 1.893 ± 0.021	1.302TyrPhe: 1.302 ± 0.019	1.876TyrGly: 1.876 ± 0.025	0.845TyrHis: 0.845 ± 0.013	1.707TyrIle: 1.707 ± 0.02	1.854TyrLys: 1.854 ± 0.022	2.794TyrLeu: 2.794 ± 0.029	0.715TyrMet: 0.715 ± 0.012	1.597TyrAsn: 1.597 ± 0.02	1.467TyrPro: 1.467 ± 0.023	1.262TyrGln: 1.262 ± 0.019	1.766TyrArg: 1.766 ± 0.021	2.308TyrSer: 2.308 ± 0.029	1.851TyrThr: 1.851 ± 0.02	1.953TyrVal: 1.953 ± 0.024	0.362TyrTrp: 0.362 ± 0.01	1.202TyrTyr: 1.202 ± 0.018	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.001XaaGlu: 0.001 ± 0.0	0.001XaaPhe: 0.001 ± 0.0	0.001XaaGly: 0.001 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.001XaaArg: 0.001 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.127XaaXaa: 0.127 ± 0.044

Statistics based on 11355 proteins (5528599 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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