Amino acid dipepetide frequency for Paracoccus tibetensis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	22.322AlaAla: 22.322 ± 0.251	1.052AlaCys: 1.052 ± 0.034	7.118AlaAsp: 7.118 ± 0.094	9.724AlaGlu: 9.724 ± 0.123	4.183AlaPhe: 4.183 ± 0.063	12.326AlaGly: 12.326 ± 0.139	2.521AlaHis: 2.521 ± 0.05	6.04AlaIle: 6.04 ± 0.083	2.813AlaLys: 2.813 ± 0.061	15.95AlaLeu: 15.95 ± 0.149	4.059AlaMet: 4.059 ± 0.061	2.291AlaAsn: 2.291 ± 0.054	7.439AlaPro: 7.439 ± 0.121	4.866AlaGln: 4.866 ± 0.091	11.128AlaArg: 11.128 ± 0.137	5.927AlaSer: 5.927 ± 0.073	5.949AlaThr: 5.949 ± 0.089	8.919AlaVal: 8.919 ± 0.097	1.674AlaTrp: 1.674 ± 0.041	2.272AlaTyr: 2.272 ± 0.044	0.0AlaXaa: 0.0 ± 0.0
Cys	1.056CysAla: 1.056 ± 0.031	0.117CysCys: 0.117 ± 0.011	0.504CysAsp: 0.504 ± 0.022	0.397CysGlu: 0.397 ± 0.018	0.27CysPhe: 0.27 ± 0.017	0.894CysGly: 0.894 ± 0.03	0.244CysHis: 0.244 ± 0.017	0.388CysIle: 0.388 ± 0.016	0.131CysLys: 0.131 ± 0.011	0.882CysLeu: 0.882 ± 0.026	0.16CysMet: 0.16 ± 0.012	0.175CysAsn: 0.175 ± 0.012	0.51CysPro: 0.51 ± 0.025	0.204CysGln: 0.204 ± 0.012	0.591CysArg: 0.591 ± 0.022	0.384CysSer: 0.384 ± 0.019	0.38CysThr: 0.38 ± 0.017	0.505CysVal: 0.505 ± 0.023	0.117CysTrp: 0.117 ± 0.01	0.172CysTyr: 0.172 ± 0.011	0.0CysXaa: 0.0 ± 0.0
Asp	7.299AspAla: 7.299 ± 0.087	0.446AspCys: 0.446 ± 0.023	2.842AspAsp: 2.842 ± 0.06	3.601AspGlu: 3.601 ± 0.062	2.1AspPhe: 2.1 ± 0.045	5.118AspGly: 5.118 ± 0.088	1.335AspHis: 1.335 ± 0.039	2.526AspIle: 2.526 ± 0.052	1.091AspLys: 1.091 ± 0.032	6.453AspLeu: 6.453 ± 0.09	1.465AspMet: 1.465 ± 0.036	0.988AspAsn: 0.988 ± 0.03	3.991AspPro: 3.991 ± 0.065	1.805AspGln: 1.805 ± 0.042	4.662AspArg: 4.662 ± 0.081	2.049AspSer: 2.049 ± 0.042	2.219AspThr: 2.219 ± 0.048	3.595AspVal: 3.595 ± 0.063	1.216AspTrp: 1.216 ± 0.033	1.367AspTyr: 1.367 ± 0.035	0.0AspXaa: 0.0 ± 0.0
Glu	9.631GluAla: 9.631 ± 0.115	0.313GluCys: 0.313 ± 0.014	3.202GluAsp: 3.202 ± 0.058	3.143GluGlu: 3.143 ± 0.058	1.594GluPhe: 1.594 ± 0.037	5.201GluGly: 5.201 ± 0.076	1.002GluHis: 1.002 ± 0.027	3.271GluIle: 3.271 ± 0.057	1.502GluLys: 1.502 ± 0.044	5.315GluLeu: 5.315 ± 0.068	1.738GluMet: 1.738 ± 0.039	1.391GluAsn: 1.391 ± 0.038	2.716GluPro: 2.716 ± 0.049	1.845GluGln: 1.845 ± 0.048	4.484GluArg: 4.484 ± 0.07	1.894GluSer: 1.894 ± 0.042	3.373GluThr: 3.373 ± 0.053	4.4GluVal: 4.4 ± 0.064	0.728GluTrp: 0.728 ± 0.026	0.861GluTyr: 0.861 ± 0.029	0.0GluXaa: 0.0 ± 0.0
Phe	4.376PheAla: 4.376 ± 0.063	0.385PheCys: 0.385 ± 0.019	2.451PheAsp: 2.451 ± 0.044	1.82PheGlu: 1.82 ± 0.038	1.31PhePhe: 1.31 ± 0.039	3.547PheGly: 3.547 ± 0.057	0.685PheHis: 0.685 ± 0.026	1.573PheIle: 1.573 ± 0.042	0.642PheLys: 0.642 ± 0.023	3.363PheLeu: 3.363 ± 0.059	0.773PheMet: 0.773 ± 0.027	0.866PheAsn: 0.866 ± 0.029	1.548PhePro: 1.548 ± 0.039	0.992PheGln: 0.992 ± 0.028	2.322PheArg: 2.322 ± 0.049	1.834PheSer: 1.834 ± 0.046	1.894PheThr: 1.894 ± 0.042	2.454PheVal: 2.454 ± 0.044	0.614PheTrp: 0.614 ± 0.025	0.784PheTyr: 0.784 ± 0.026	0.0PheXaa: 0.0 ± 0.0
Gly	11.076GlyAla: 11.076 ± 0.123	0.805GlyCys: 0.805 ± 0.029	4.357GlyAsp: 4.357 ± 0.071	4.695GlyGlu: 4.695 ± 0.078	3.581GlyPhe: 3.581 ± 0.06	7.734GlyGly: 7.734 ± 0.133	1.968GlyHis: 1.968 ± 0.036	4.609GlyIle: 4.609 ± 0.065	2.385GlyLys: 2.385 ± 0.054	9.786GlyLeu: 9.786 ± 0.112	2.645GlyMet: 2.645 ± 0.05	1.962GlyAsn: 1.962 ± 0.058	4.042GlyPro: 4.042 ± 0.072	3.413GlyGln: 3.413 ± 0.056	7.161GlyArg: 7.161 ± 0.077	4.259GlySer: 4.259 ± 0.054	4.716GlyThr: 4.716 ± 0.067	6.055GlyVal: 6.055 ± 0.078	1.601GlyTrp: 1.601 ± 0.042	2.047GlyTyr: 2.047 ± 0.048	0.0GlyXaa: 0.0 ± 0.0
His	2.455HisAla: 2.455 ± 0.047	0.212HisCys: 0.212 ± 0.012	1.354HisAsp: 1.354 ± 0.039	1.092HisGlu: 1.092 ± 0.034	0.754HisPhe: 0.754 ± 0.027	2.032HisGly: 2.032 ± 0.05	0.551HisHis: 0.551 ± 0.027	0.791HisIle: 0.791 ± 0.028	0.375HisLys: 0.375 ± 0.018	2.275HisLeu: 2.275 ± 0.043	0.538HisMet: 0.538 ± 0.022	0.411HisAsn: 0.411 ± 0.019	1.485HisPro: 1.485 ± 0.036	0.636HisGln: 0.636 ± 0.025	1.534HisArg: 1.534 ± 0.035	0.865HisSer: 0.865 ± 0.028	0.648HisThr: 0.648 ± 0.026	1.589HisVal: 1.589 ± 0.036	0.322HisTrp: 0.322 ± 0.018	0.475HisTyr: 0.475 ± 0.019	0.0HisXaa: 0.0 ± 0.0
Ile	7.307IleAla: 7.307 ± 0.084	0.568IleCys: 0.568 ± 0.022	3.188IleAsp: 3.188 ± 0.058	3.211IleGlu: 3.211 ± 0.052	1.772IlePhe: 1.772 ± 0.042	4.779IleGly: 4.779 ± 0.071	0.927IleHis: 0.927 ± 0.029	2.103IleIle: 2.103 ± 0.05	0.947IleLys: 0.947 ± 0.03	4.86IleLeu: 4.86 ± 0.076	1.063IleMet: 1.063 ± 0.033	1.106IleAsn: 1.106 ± 0.035	2.376IlePro: 2.376 ± 0.043	1.118IleGln: 1.118 ± 0.032	3.536IleArg: 3.536 ± 0.055	2.577IleSer: 2.577 ± 0.05	2.609IleThr: 2.609 ± 0.051	3.563IleVal: 3.563 ± 0.061	0.749IleTrp: 0.749 ± 0.024	1.037IleTyr: 1.037 ± 0.032	0.0IleXaa: 0.0 ± 0.0
Lys	3.03LysAla: 3.03 ± 0.07	0.11LysCys: 0.11 ± 0.01	1.238LysAsp: 1.238 ± 0.033	1.004LysGlu: 1.004 ± 0.032	0.6LysPhe: 0.6 ± 0.027	2.076LysGly: 2.076 ± 0.052	0.433LysHis: 0.433 ± 0.021	1.194LysIle: 1.194 ± 0.036	0.773LysLys: 0.773 ± 0.035	2.241LysLeu: 2.241 ± 0.046	0.604LysMet: 0.604 ± 0.023	0.553LysAsn: 0.553 ± 0.02	1.423LysPro: 1.423 ± 0.047	0.633LysGln: 0.633 ± 0.024	1.666LysArg: 1.666 ± 0.042	1.245LysSer: 1.245 ± 0.039	1.332LysThr: 1.332 ± 0.029	1.635LysVal: 1.635 ± 0.041	0.256LysTrp: 0.256 ± 0.013	0.424LysTyr: 0.424 ± 0.021	0.0LysXaa: 0.0 ± 0.0
Leu	15.879LeuAla: 15.879 ± 0.154	0.871LeuCys: 0.871 ± 0.028	6.225LeuAsp: 6.225 ± 0.083	5.277LeuGlu: 5.277 ± 0.083	3.229LeuPhe: 3.229 ± 0.067	8.792LeuGly: 8.792 ± 0.099	2.011LeuHis: 2.011 ± 0.047	5.291LeuIle: 5.291 ± 0.078	2.401LeuLys: 2.401 ± 0.052	9.88LeuLeu: 9.88 ± 0.131	2.814LeuMet: 2.814 ± 0.051	2.392LeuAsn: 2.392 ± 0.049	6.622LeuPro: 6.622 ± 0.09	2.782LeuGln: 2.782 ± 0.044	8.508LeuArg: 8.508 ± 0.103	6.344LeuSer: 6.344 ± 0.084	6.311LeuThr: 6.311 ± 0.076	7.426LeuVal: 7.426 ± 0.098	1.445LeuTrp: 1.445 ± 0.038	1.862LeuTyr: 1.862 ± 0.038	0.001LeuXaa: 0.001 ± 0.001
Met	3.707MetAla: 3.707 ± 0.049	0.16MetCys: 0.16 ± 0.011	1.335MetAsp: 1.335 ± 0.034	1.22MetGlu: 1.22 ± 0.029	0.766MetPhe: 0.766 ± 0.028	2.237MetGly: 2.237 ± 0.045	0.419MetHis: 0.419 ± 0.023	1.568MetIle: 1.568 ± 0.042	0.818MetLys: 0.818 ± 0.027	2.844MetLeu: 2.844 ± 0.048	0.757MetMet: 0.757 ± 0.025	0.778MetAsn: 0.778 ± 0.025	1.638MetPro: 1.638 ± 0.04	0.982MetGln: 0.982 ± 0.03	2.084MetArg: 2.084 ± 0.039	1.696MetSer: 1.696 ± 0.036	2.075MetThr: 2.075 ± 0.042	1.781MetVal: 1.781 ± 0.042	0.281MetTrp: 0.281 ± 0.016	0.258MetTyr: 0.258 ± 0.015	0.0MetXaa: 0.0 ± 0.0
Asn	2.758AsnAla: 2.758 ± 0.047	0.225AsnCys: 0.225 ± 0.015	1.166AsnAsp: 1.166 ± 0.047	1.012AsnGlu: 1.012 ± 0.03	0.782AsnPhe: 0.782 ± 0.026	1.926AsnGly: 1.926 ± 0.047	0.444AsnHis: 0.444 ± 0.016	1.162AsnIle: 1.162 ± 0.034	0.435AsnLys: 0.435 ± 0.02	2.365AsnLeu: 2.365 ± 0.048	0.603AsnMet: 0.603 ± 0.021	0.523AsnAsn: 0.523 ± 0.024	1.637AsnPro: 1.637 ± 0.035	0.636AsnGln: 0.636 ± 0.023	1.705AsnArg: 1.705 ± 0.038	1.008AsnSer: 1.008 ± 0.03	1.005AsnThr: 1.005 ± 0.036	1.562AsnVal: 1.562 ± 0.039	0.417AsnTrp: 0.417 ± 0.019	0.539AsnTyr: 0.539 ± 0.022	0.0AsnXaa: 0.0 ± 0.0
Pro	8.054ProAla: 8.054 ± 0.121	0.368ProCys: 0.368 ± 0.017	3.976ProAsp: 3.976 ± 0.062	4.423ProGlu: 4.423 ± 0.059	1.942ProPhe: 1.942 ± 0.043	5.156ProGly: 5.156 ± 0.07	1.126ProHis: 1.126 ± 0.032	2.182ProIle: 2.182 ± 0.047	1.192ProLys: 1.192 ± 0.036	5.408ProLeu: 5.408 ± 0.076	1.386ProMet: 1.386 ± 0.032	1.163ProAsn: 1.163 ± 0.036	2.91ProPro: 2.91 ± 0.075	1.982ProGln: 1.982 ± 0.044	3.681ProArg: 3.681 ± 0.064	2.49ProSer: 2.49 ± 0.048	2.308ProThr: 2.308 ± 0.048	4.534ProVal: 4.534 ± 0.067	0.78ProTrp: 0.78 ± 0.026	1.025ProTyr: 1.025 ± 0.029	0.0ProXaa: 0.0 ± 0.0
Gln	4.44GlnAla: 4.44 ± 0.082	0.172GlnCys: 0.172 ± 0.011	1.692GlnAsp: 1.692 ± 0.04	1.477GlnGlu: 1.477 ± 0.039	1.03GlnPhe: 1.03 ± 0.029	2.885GlnGly: 2.885 ± 0.049	0.633GlnHis: 0.633 ± 0.024	2.013GlnIle: 2.013 ± 0.042	0.788GlnLys: 0.788 ± 0.025	3.237GlnLeu: 3.237 ± 0.053	1.156GlnMet: 1.156 ± 0.032	0.843GlnAsn: 0.843 ± 0.029	1.98GlnPro: 1.98 ± 0.041	1.317GlnGln: 1.317 ± 0.04	2.547GlnArg: 2.547 ± 0.053	1.565GlnSer: 1.565 ± 0.041	1.682GlnThr: 1.682 ± 0.04	2.567GlnVal: 2.567 ± 0.048	0.376GlnTrp: 0.376 ± 0.019	0.464GlnTyr: 0.464 ± 0.021	0.0GlnXaa: 0.0 ± 0.0
Arg	9.944ArgAla: 9.944 ± 0.112	0.521ArgCys: 0.521 ± 0.021	4.345ArgAsp: 4.345 ± 0.059	4.328ArgGlu: 4.328 ± 0.072	2.79ArgPhe: 2.79 ± 0.047	5.419ArgGly: 5.419 ± 0.07	1.911ArgHis: 1.911 ± 0.046	4.388ArgIle: 4.388 ± 0.06	1.84ArgLys: 1.84 ± 0.04	9.122ArgLeu: 9.122 ± 0.115	2.322ArgMet: 2.322 ± 0.044	1.677ArgAsn: 1.677 ± 0.035	4.363ArgPro: 4.363 ± 0.069	2.98ArgGln: 2.98 ± 0.048	6.596ArgArg: 6.596 ± 0.093	3.488ArgSer: 3.488 ± 0.059	3.141ArgThr: 3.141 ± 0.061	5.03ArgVal: 5.03 ± 0.067	1.102ArgTrp: 1.102 ± 0.033	1.505ArgTyr: 1.505 ± 0.035	0.0ArgXaa: 0.0 ± 0.0
Ser	5.835SerAla: 5.835 ± 0.085	0.417SerCys: 0.417 ± 0.021	2.736SerAsp: 2.736 ± 0.047	2.463SerGlu: 2.463 ± 0.048	2.097SerPhe: 2.097 ± 0.041	5.241SerGly: 5.241 ± 0.077	1.023SerHis: 1.023 ± 0.029	2.186SerIle: 2.186 ± 0.05	0.994SerLys: 0.994 ± 0.031	4.974SerLeu: 4.974 ± 0.065	1.203SerMet: 1.203 ± 0.029	1.07SerAsn: 1.07 ± 0.03	2.623SerPro: 2.623 ± 0.044	1.496SerGln: 1.496 ± 0.037	3.614SerArg: 3.614 ± 0.068	2.357SerSer: 2.357 ± 0.053	2.229SerThr: 2.229 ± 0.04	3.323SerVal: 3.323 ± 0.057	0.762SerTrp: 0.762 ± 0.023	1.114SerTyr: 1.114 ± 0.032	0.0SerXaa: 0.0 ± 0.0
Thr	6.373ThrAla: 6.373 ± 0.079	0.441ThrCys: 0.441 ± 0.021	2.855ThrAsp: 2.855 ± 0.057	2.966ThrGlu: 2.966 ± 0.057	1.651ThrPhe: 1.651 ± 0.046	5.375ThrGly: 5.375 ± 0.077	1.062ThrHis: 1.062 ± 0.03	2.525ThrIle: 2.525 ± 0.051	0.976ThrLys: 0.976 ± 0.03	5.581ThrLeu: 5.581 ± 0.075	1.156ThrMet: 1.156 ± 0.032	1.097ThrAsn: 1.097 ± 0.031	3.178ThrPro: 3.178 ± 0.053	1.553ThrGln: 1.553 ± 0.037	3.715ThrArg: 3.715 ± 0.056	2.341ThrSer: 2.341 ± 0.048	2.67ThrThr: 2.67 ± 0.063	3.825ThrVal: 3.825 ± 0.06	0.619ThrTrp: 0.619 ± 0.023	1.021ThrTyr: 1.021 ± 0.034	0.0ThrXaa: 0.0 ± 0.0
Val	9.345ValAla: 9.345 ± 0.091	0.563ValCys: 0.563 ± 0.022	3.505ValAsp: 3.505 ± 0.057	4.165ValGlu: 4.165 ± 0.051	2.489ValPhe: 2.489 ± 0.045	5.227ValGly: 5.227 ± 0.084	1.292ValHis: 1.292 ± 0.039	4.119ValIle: 4.119 ± 0.072	1.578ValLys: 1.578 ± 0.045	7.801ValLeu: 7.801 ± 0.089	2.156ValMet: 2.156 ± 0.046	1.715ValAsn: 1.715 ± 0.046	3.771ValPro: 3.771 ± 0.058	2.237ValGln: 2.237 ± 0.046	4.414ValArg: 4.414 ± 0.064	3.651ValSer: 3.651 ± 0.058	4.73ValThr: 4.73 ± 0.066	5.31ValVal: 5.31 ± 0.09	0.937ValTrp: 0.937 ± 0.03	1.218ValTyr: 1.218 ± 0.035	0.0ValXaa: 0.0 ± 0.0
Trp	1.399TrpAla: 1.399 ± 0.038	0.124TrpCys: 0.124 ± 0.011	0.74TrpAsp: 0.74 ± 0.027	0.582TrpGlu: 0.582 ± 0.024	0.585TrpPhe: 0.585 ± 0.025	1.057TrpGly: 1.057 ± 0.032	0.344TrpHis: 0.344 ± 0.018	0.704TrpIle: 0.704 ± 0.026	0.386TrpLys: 0.386 ± 0.019	1.919TrpLeu: 1.919 ± 0.047	0.405TrpMet: 0.405 ± 0.021	0.409TrpAsn: 0.409 ± 0.019	0.825TrpPro: 0.825 ± 0.025	0.754TrpGln: 0.754 ± 0.026	1.328TrpArg: 1.328 ± 0.035	0.865TrpSer: 0.865 ± 0.029	0.818TrpThr: 0.818 ± 0.029	0.831TrpVal: 0.831 ± 0.028	0.259TrpTrp: 0.259 ± 0.015	0.241TrpTyr: 0.241 ± 0.014	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.286TyrAla: 2.286 ± 0.049	0.21TyrCys: 0.21 ± 0.013	1.344TyrAsp: 1.344 ± 0.034	1.006TyrGlu: 1.006 ± 0.03	0.71TyrPhe: 0.71 ± 0.028	1.874TyrGly: 1.874 ± 0.047	0.459TyrHis: 0.459 ± 0.019	0.764TyrIle: 0.764 ± 0.029	0.404TyrLys: 0.404 ± 0.018	2.107TyrLeu: 2.107 ± 0.044	0.4TyrMet: 0.4 ± 0.018	0.501TyrAsn: 0.501 ± 0.022	1.006TyrPro: 1.006 ± 0.029	0.63TyrGln: 0.63 ± 0.023	1.535TyrArg: 1.535 ± 0.035	0.922TyrSer: 0.922 ± 0.027	0.89TyrThr: 0.89 ± 0.028	1.32TyrVal: 1.32 ± 0.03	0.319TyrTrp: 0.319 ± 0.013	0.511TyrTyr: 0.511 ± 0.023	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.001XaaGly: 0.001 ± 0.001	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.006XaaXaa: 0.006 ± 0.006

Statistics based on 3733 proteins (1171507 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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