Amino acid dipepetide frequency for Treponema caldarium (strain ATCC 51460 / DSM 7334 / H1) (Spirochaeta caldaria)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
7.629AlaAla: 7.629 ± 0.154
0.827AlaCys: 0.827 ± 0.033
4.053AlaAsp: 4.053 ± 0.076
5.765AlaGlu: 5.765 ± 0.098
3.71AlaPhe: 3.71 ± 0.066
6.481AlaGly: 6.481 ± 0.111
1.466AlaHis: 1.466 ± 0.043
5.774AlaIle: 5.774 ± 0.093
4.039AlaLys: 4.039 ± 0.066
10.152AlaLeu: 10.152 ± 0.14
2.042AlaMet: 2.042 ± 0.045
2.402AlaAsn: 2.402 ± 0.05
2.793AlaPro: 2.793 ± 0.061
3.312AlaGln: 3.312 ± 0.075
4.269AlaArg: 4.269 ± 0.085
4.999AlaSer: 4.999 ± 0.086
3.643AlaThr: 3.643 ± 0.069
5.787AlaVal: 5.787 ± 0.088
0.924AlaTrp: 0.924 ± 0.033
2.765AlaTyr: 2.765 ± 0.063
0.0AlaXaa: 0.0 ± 0.0
Cys
0.662CysAla: 0.662 ± 0.027
0.108CysCys: 0.108 ± 0.012
0.456CysAsp: 0.456 ± 0.023
0.447CysGlu: 0.447 ± 0.02
0.401CysPhe: 0.401 ± 0.022
0.786CysGly: 0.786 ± 0.035
0.194CysHis: 0.194 ± 0.014
0.751CysIle: 0.751 ± 0.024
0.43CysLys: 0.43 ± 0.021
0.747CysLeu: 0.747 ± 0.029
0.192CysMet: 0.192 ± 0.015
0.31CysAsn: 0.31 ± 0.019
0.459CysPro: 0.459 ± 0.025
0.246CysGln: 0.246 ± 0.015
0.547CysArg: 0.547 ± 0.022
0.623CysSer: 0.623 ± 0.026
0.579CysThr: 0.579 ± 0.028
0.512CysVal: 0.512 ± 0.021
0.083CysTrp: 0.083 ± 0.009
0.289CysTyr: 0.289 ± 0.017
0.0CysXaa: 0.0 ± 0.0
Asp
4.155AspAla: 4.155 ± 0.072
0.47AspCys: 0.47 ± 0.026
2.261AspAsp: 2.261 ± 0.056
3.776AspGlu: 3.776 ± 0.069
2.42AspPhe: 2.42 ± 0.049
3.637AspGly: 3.637 ± 0.067
0.861AspHis: 0.861 ± 0.032
3.98AspIle: 3.98 ± 0.062
2.554AspLys: 2.554 ± 0.057
5.337AspLeu: 5.337 ± 0.07
1.21AspMet: 1.21 ± 0.037
1.527AspAsn: 1.527 ± 0.044
2.859AspPro: 2.859 ± 0.057
1.672AspGln: 1.672 ± 0.047
3.131AspArg: 3.131 ± 0.062
2.833AspSer: 2.833 ± 0.062
2.984AspThr: 2.984 ± 0.063
3.209AspVal: 3.209 ± 0.059
0.706AspTrp: 0.706 ± 0.03
1.914AspTyr: 1.914 ± 0.045
0.0AspXaa: 0.0 ± 0.0
Glu
6.276GluAla: 6.276 ± 0.11
0.401GluCys: 0.401 ± 0.02
3.016GluAsp: 3.016 ± 0.061
4.398GluGlu: 4.398 ± 0.087
2.106GluPhe: 2.106 ± 0.052
4.302GluGly: 4.302 ± 0.063
1.369GluHis: 1.369 ± 0.038
4.581GluIle: 4.581 ± 0.079
4.481GluLys: 4.481 ± 0.081
7.342GluLeu: 7.342 ± 0.093
1.387GluMet: 1.387 ± 0.044
2.401GluAsn: 2.401 ± 0.057
2.195GluPro: 2.195 ± 0.051
3.177GluGln: 3.177 ± 0.064
4.205GluArg: 4.205 ± 0.082
3.48GluSer: 3.48 ± 0.067
3.757GluThr: 3.757 ± 0.073
3.716GluVal: 3.716 ± 0.062
0.665GluTrp: 0.665 ± 0.026
2.099GluTyr: 2.099 ± 0.046
0.0GluXaa: 0.0 ± 0.0
Phe
3.326PheAla: 3.326 ± 0.073
0.499PheCys: 0.499 ± 0.022
2.335PheAsp: 2.335 ± 0.053
2.378PheGlu: 2.378 ± 0.052
2.208PhePhe: 2.208 ± 0.059
3.036PheGly: 3.036 ± 0.07
0.785PheHis: 0.785 ± 0.031
3.747PheIle: 3.747 ± 0.073
2.049PheLys: 2.049 ± 0.05
4.298PheLeu: 4.298 ± 0.075
1.013PheMet: 1.013 ± 0.032
1.677PheAsn: 1.677 ± 0.048
1.91PhePro: 1.91 ± 0.047
1.348PheGln: 1.348 ± 0.045
2.045PheArg: 2.045 ± 0.056
3.529PheSer: 3.529 ± 0.068
2.79PheThr: 2.79 ± 0.066
2.59PheVal: 2.59 ± 0.055
0.56PheTrp: 0.56 ± 0.026
1.529PheTyr: 1.529 ± 0.044
0.0PheXaa: 0.0 ± 0.0
Gly
5.496GlyAla: 5.496 ± 0.114
0.689GlyCys: 0.689 ± 0.025
3.152GlyAsp: 3.152 ± 0.066
3.659GlyGlu: 3.659 ± 0.072
3.42GlyPhe: 3.42 ± 0.063
4.822GlyGly: 4.822 ± 0.115
1.232GlyHis: 1.232 ± 0.041
5.853GlyIle: 5.853 ± 0.088
4.667GlyLys: 4.667 ± 0.079
7.236GlyLeu: 7.236 ± 0.093
1.879GlyMet: 1.879 ± 0.048
2.641GlyAsn: 2.641 ± 0.069
2.587GlyPro: 2.587 ± 0.059
2.128GlyGln: 2.128 ± 0.051
3.771GlyArg: 3.771 ± 0.07
4.822GlySer: 4.822 ± 0.082
4.795GlyThr: 4.795 ± 0.136
4.395GlyVal: 4.395 ± 0.085
0.894GlyTrp: 0.894 ± 0.035
2.586GlyTyr: 2.586 ± 0.057
0.0GlyXaa: 0.0 ± 0.0
His
1.299HisAla: 1.299 ± 0.037
0.27HisCys: 0.27 ± 0.015
0.87HisAsp: 0.87 ± 0.027
1.144HisGlu: 1.144 ± 0.033
0.948HisPhe: 0.948 ± 0.029
1.341HisGly: 1.341 ± 0.042
0.533HisHis: 0.533 ± 0.025
1.513HisIle: 1.513 ± 0.045
0.799HisLys: 0.799 ± 0.029
1.835HisLeu: 1.835 ± 0.045
0.343HisMet: 0.343 ± 0.019
0.689HisAsn: 0.689 ± 0.026
1.182HisPro: 1.182 ± 0.036
0.784HisGln: 0.784 ± 0.028
1.182HisArg: 1.182 ± 0.035
1.078HisSer: 1.078 ± 0.04
0.967HisThr: 0.967 ± 0.035
0.979HisVal: 0.979 ± 0.033
0.26HisTrp: 0.26 ± 0.018
0.73HisTyr: 0.73 ± 0.031
0.0HisXaa: 0.0 ± 0.0
Ile
6.257IleAla: 6.257 ± 0.095
0.602IleCys: 0.602 ± 0.025
4.369IleAsp: 4.369 ± 0.076
4.951IleGlu: 4.951 ± 0.079
2.754IlePhe: 2.754 ± 0.061
4.983IleGly: 4.983 ± 0.081
1.501IleHis: 1.501 ± 0.045
5.59IleIle: 5.59 ± 0.093
3.864IleLys: 3.864 ± 0.066
7.586IleLeu: 7.586 ± 0.116
1.407IleMet: 1.407 ± 0.047
2.955IleAsn: 2.955 ± 0.062
4.157IlePro: 4.157 ± 0.08
3.065IleGln: 3.065 ± 0.063
4.048IleArg: 4.048 ± 0.062
4.883IleSer: 4.883 ± 0.07
4.163IleThr: 4.163 ± 0.069
4.626IleVal: 4.626 ± 0.075
0.673IleTrp: 0.673 ± 0.032
2.089IleTyr: 2.089 ± 0.045
0.0IleXaa: 0.0 ± 0.0
Lys
5.025LysAla: 5.025 ± 0.084
0.239LysCys: 0.239 ± 0.02
3.247LysAsp: 3.247 ± 0.068
4.23LysGlu: 4.23 ± 0.086
1.239LysPhe: 1.239 ± 0.038
3.682LysGly: 3.682 ± 0.062
0.943LysHis: 0.943 ± 0.036
3.883LysIle: 3.883 ± 0.068
4.157LysLys: 4.157 ± 0.088
4.865LysLeu: 4.865 ± 0.075
1.258LysMet: 1.258 ± 0.035
2.72LysAsn: 2.72 ± 0.06
2.459LysPro: 2.459 ± 0.054
2.156LysGln: 2.156 ± 0.049
3.06LysArg: 3.06 ± 0.064
2.921LysSer: 2.921 ± 0.057
3.639LysThr: 3.639 ± 0.071
3.225LysVal: 3.225 ± 0.056
0.411LysTrp: 0.411 ± 0.021
1.664LysTyr: 1.664 ± 0.049
0.0LysXaa: 0.0 ± 0.0
Leu
9.193LeuAla: 9.193 ± 0.131
0.996LeuCys: 0.996 ± 0.032
5.48LeuAsp: 5.48 ± 0.08
7.221LeuGlu: 7.221 ± 0.1
5.189LeuPhe: 5.189 ± 0.101
7.151LeuGly: 7.151 ± 0.092
2.021LeuHis: 2.021 ± 0.046
6.929LeuIle: 6.929 ± 0.108
5.71LeuLys: 5.71 ± 0.09
10.622LeuLeu: 10.622 ± 0.161
2.244LeuMet: 2.244 ± 0.049
3.566LeuAsn: 3.566 ± 0.078
4.813LeuPro: 4.813 ± 0.081
4.2LeuGln: 4.2 ± 0.069
5.196LeuArg: 5.196 ± 0.069
7.77LeuSer: 7.77 ± 0.094
5.008LeuThr: 5.008 ± 0.07
7.292LeuVal: 7.292 ± 0.115
1.185LeuTrp: 1.185 ± 0.036
3.647LeuTyr: 3.647 ± 0.065
0.0LeuXaa: 0.0 ± 0.0
Met
2.085MetAla: 2.085 ± 0.044
0.116MetCys: 0.116 ± 0.011
1.252MetAsp: 1.252 ± 0.038
1.509MetGlu: 1.509 ± 0.041
0.714MetPhe: 0.714 ± 0.028
1.759MetGly: 1.759 ± 0.049
0.347MetHis: 0.347 ± 0.019
1.558MetIle: 1.558 ± 0.044
1.718MetLys: 1.718 ± 0.042
2.16MetLeu: 2.16 ± 0.053
0.53MetMet: 0.53 ± 0.026
1.195MetAsn: 1.195 ± 0.038
0.911MetPro: 0.911 ± 0.032
0.776MetGln: 0.776 ± 0.028
0.96MetArg: 0.96 ± 0.037
1.216MetSer: 1.216 ± 0.032
1.235MetThr: 1.235 ± 0.041
1.773MetVal: 1.773 ± 0.04
0.129MetTrp: 0.129 ± 0.012
0.606MetTyr: 0.606 ± 0.024
0.0MetXaa: 0.0 ± 0.0
Asn
2.633AsnAla: 2.633 ± 0.059
0.334AsnCys: 0.334 ± 0.018
1.709AsnAsp: 1.709 ± 0.049
2.116AsnGlu: 2.116 ± 0.046
1.471AsnPhe: 1.471 ± 0.044
2.636AsnGly: 2.636 ± 0.09
0.753AsnHis: 0.753 ± 0.029
2.763AsnIle: 2.763 ± 0.061
2.008AsnLys: 2.008 ± 0.046
4.23AsnLeu: 4.23 ± 0.073
0.895AsnMet: 0.895 ± 0.033
1.626AsnAsn: 1.626 ± 0.049
2.313AsnPro: 2.313 ± 0.05
1.466AsnGln: 1.466 ± 0.042
2.372AsnArg: 2.372 ± 0.052
2.063AsnSer: 2.063 ± 0.058
2.116AsnThr: 2.116 ± 0.05
1.986AsnVal: 1.986 ± 0.065
0.471AsnTrp: 0.471 ± 0.027
1.401AsnTyr: 1.401 ± 0.042
0.0AsnXaa: 0.0 ± 0.0
Pro
3.513ProAla: 3.513 ± 0.068
0.376ProCys: 0.376 ± 0.02
2.628ProAsp: 2.628 ± 0.049
3.755ProGlu: 3.755 ± 0.062
2.062ProPhe: 2.062 ± 0.047
3.189ProGly: 3.189 ± 0.064
0.87ProHis: 0.87 ± 0.029
3.026ProIle: 3.026 ± 0.066
1.839ProLys: 1.839 ± 0.045
4.56ProLeu: 4.56 ± 0.085
0.873ProMet: 0.873 ± 0.033
1.455ProAsn: 1.455 ± 0.04
1.605ProPro: 1.605 ± 0.051
1.636ProGln: 1.636 ± 0.045
1.782ProArg: 1.782 ± 0.042
2.495ProSer: 2.495 ± 0.057
2.013ProThr: 2.013 ± 0.044
3.53ProVal: 3.53 ± 0.06
0.61ProTrp: 0.61 ± 0.028
1.64ProTyr: 1.64 ± 0.045
0.0ProXaa: 0.0 ± 0.0
Gln
3.333GlnAla: 3.333 ± 0.071
0.248GlnCys: 0.248 ± 0.017
2.171GlnAsp: 2.171 ± 0.045
2.742GlnGlu: 2.742 ± 0.061
1.527GlnPhe: 1.527 ± 0.037
2.809GlnGly: 2.809 ± 0.065
0.705GlnHis: 0.705 ± 0.027
2.482GlnIle: 2.482 ± 0.055
2.489GlnLys: 2.489 ± 0.05
3.316GlnLeu: 3.316 ± 0.061
0.768GlnMet: 0.768 ± 0.025
1.751GlnAsn: 1.751 ± 0.046
1.157GlnPro: 1.157 ± 0.036
1.583GlnGln: 1.583 ± 0.047
2.155GlnArg: 2.155 ± 0.054
2.18GlnSer: 2.18 ± 0.046
1.855GlnThr: 1.855 ± 0.048
2.615GlnVal: 2.615 ± 0.054
0.469GlnTrp: 0.469 ± 0.024
1.298GlnTyr: 1.298 ± 0.036
0.0GlnXaa: 0.0 ± 0.0
Arg
3.889ArgAla: 3.889 ± 0.07
0.495ArgCys: 0.495 ± 0.025
2.899ArgAsp: 2.899 ± 0.057
3.622ArgGlu: 3.622 ± 0.069
2.74ArgPhe: 2.74 ± 0.058
3.259ArgGly: 3.259 ± 0.054
0.921ArgHis: 0.921 ± 0.032
4.444ArgIle: 4.444 ± 0.073
2.924ArgLys: 2.924 ± 0.066
6.082ArgLeu: 6.082 ± 0.098
1.279ArgMet: 1.279 ± 0.04
2.069ArgAsn: 2.069 ± 0.045
1.993ArgPro: 1.993 ± 0.043
1.835ArgGln: 1.835 ± 0.048
3.106ArgArg: 3.106 ± 0.069
3.472ArgSer: 3.472 ± 0.062
2.854ArgThr: 2.854 ± 0.058
2.933ArgVal: 2.933 ± 0.061
0.714ArgTrp: 0.714 ± 0.028
2.172ArgTyr: 2.172 ± 0.049
0.0ArgXaa: 0.0 ± 0.0
Ser
4.9SerAla: 4.9 ± 0.078
0.656SerCys: 0.656 ± 0.032
2.983SerAsp: 2.983 ± 0.058
3.597SerGlu: 3.597 ± 0.067
3.266SerPhe: 3.266 ± 0.06
5.086SerGly: 5.086 ± 0.088
1.096SerHis: 1.096 ± 0.036
5.001SerIle: 5.001 ± 0.079
2.817SerLys: 2.817 ± 0.051
7.091SerLeu: 7.091 ± 0.106
1.479SerMet: 1.479 ± 0.039
2.005SerAsn: 2.005 ± 0.055
2.691SerPro: 2.691 ± 0.059
2.2SerGln: 2.2 ± 0.048
3.481SerArg: 3.481 ± 0.068
4.156SerSer: 4.156 ± 0.074
3.124SerThr: 3.124 ± 0.069
4.214SerVal: 4.214 ± 0.059
0.858SerTrp: 0.858 ± 0.033
2.269SerTyr: 2.269 ± 0.051
0.0SerXaa: 0.0 ± 0.0
Thr
4.673ThrAla: 4.673 ± 0.082
0.461ThrCys: 0.461 ± 0.022
2.768ThrAsp: 2.768 ± 0.06
3.387ThrGlu: 3.387 ± 0.065
2.281ThrPhe: 2.281 ± 0.06
4.494ThrGly: 4.494 ± 0.082
0.886ThrHis: 0.886 ± 0.034
4.753ThrIle: 4.753 ± 0.082
2.571ThrLys: 2.571 ± 0.06
5.952ThrLeu: 5.952 ± 0.1
1.294ThrMet: 1.294 ± 0.038
2.107ThrAsn: 2.107 ± 0.062
2.274ThrPro: 2.274 ± 0.047
1.688ThrGln: 1.688 ± 0.043
2.095ThrArg: 2.095 ± 0.05
3.181ThrSer: 3.181 ± 0.066
3.176ThrThr: 3.176 ± 0.09
4.031ThrVal: 4.031 ± 0.081
0.615ThrTrp: 0.615 ± 0.029
1.913ThrTyr: 1.913 ± 0.046
0.0ThrXaa: 0.0 ± 0.0
Val
5.275ValAla: 5.275 ± 0.078
0.607ValCys: 0.607 ± 0.026
3.365ValAsp: 3.365 ± 0.069
3.79ValGlu: 3.79 ± 0.065
2.976ValPhe: 2.976 ± 0.062
3.993ValGly: 3.993 ± 0.074
1.325ValHis: 1.325 ± 0.037
4.571ValIle: 4.571 ± 0.082
3.257ValLys: 3.257 ± 0.068
7.313ValLeu: 7.313 ± 0.097
1.486ValMet: 1.486 ± 0.04
2.19ValAsn: 2.19 ± 0.055
3.005ValPro: 3.005 ± 0.066
2.602ValGln: 2.602 ± 0.046
3.429ValArg: 3.429 ± 0.061
4.617ValSer: 4.617 ± 0.072
3.385ValThr: 3.385 ± 0.095
4.726ValVal: 4.726 ± 0.09
0.682ValTrp: 0.682 ± 0.028
2.258ValTyr: 2.258 ± 0.052
0.0ValXaa: 0.0 ± 0.0
Trp
0.923TrpAla: 0.923 ± 0.034
0.106TrpCys: 0.106 ± 0.012
0.691TrpAsp: 0.691 ± 0.029
0.739TrpGlu: 0.739 ± 0.03
0.559TrpPhe: 0.559 ± 0.024
0.737TrpGly: 0.737 ± 0.032
0.213TrpHis: 0.213 ± 0.015
0.806TrpIle: 0.806 ± 0.028
0.769TrpLys: 0.769 ± 0.03
1.096TrpLeu: 1.096 ± 0.038
0.268TrpMet: 0.268 ± 0.019
0.644TrpAsn: 0.644 ± 0.025
0.413TrpPro: 0.413 ± 0.02
0.452TrpGln: 0.452 ± 0.023
0.542TrpArg: 0.542 ± 0.028
0.632TrpSer: 0.632 ± 0.028
0.6TrpThr: 0.6 ± 0.027
0.731TrpVal: 0.731 ± 0.025
0.151TrpTrp: 0.151 ± 0.014
0.48TrpTyr: 0.48 ± 0.025
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.29TyrAla: 2.29 ± 0.053
0.321TyrCys: 0.321 ± 0.019
1.791TyrAsp: 1.791 ± 0.042
2.128TyrGlu: 2.128 ± 0.046
1.663TyrPhe: 1.663 ± 0.041
2.541TyrGly: 2.541 ± 0.052
0.725TyrHis: 0.725 ± 0.029
2.518TyrIle: 2.518 ± 0.057
1.883TyrLys: 1.883 ± 0.049
3.614TyrLeu: 3.614 ± 0.064
0.704TyrMet: 0.704 ± 0.03
1.43TyrAsn: 1.43 ± 0.038
1.681TyrPro: 1.681 ± 0.048
1.325TyrGln: 1.325 ± 0.035
2.327TyrArg: 2.327 ± 0.052
2.022TyrSer: 2.022 ± 0.048
1.913TyrThr: 1.913 ± 0.051
1.986TyrVal: 1.986 ± 0.047
0.489TyrTrp: 0.489 ± 0.024
1.34TyrTyr: 1.34 ± 0.044
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2754 proteins (973006 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski