Amino acid dipepetide frequency for Photobacterium jeanii

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	8.702AlaAla: 8.702 ± 0.109	1.032AlaCys: 1.032 ± 0.031	4.961AlaAsp: 4.961 ± 0.066	5.945AlaGlu: 5.945 ± 0.086	3.598AlaPhe: 3.598 ± 0.056	6.393AlaGly: 6.393 ± 0.091	1.729AlaHis: 1.729 ± 0.039	6.099AlaIle: 6.099 ± 0.068	5.157AlaLys: 5.157 ± 0.067	10.128AlaLeu: 10.128 ± 0.095	3.081AlaMet: 3.081 ± 0.052	3.908AlaAsn: 3.908 ± 0.057	3.1AlaPro: 3.1 ± 0.06	4.367AlaGln: 4.367 ± 0.058	3.687AlaArg: 3.687 ± 0.058	5.618AlaSer: 5.618 ± 0.07	4.851AlaThr: 4.851 ± 0.062	6.378AlaVal: 6.378 ± 0.074	1.027AlaTrp: 1.027 ± 0.03	2.394AlaTyr: 2.394 ± 0.041	0.0AlaXaa: 0.0 ± 0.0
Cys	0.797CysAla: 0.797 ± 0.026	0.201CysCys: 0.201 ± 0.012	0.63CysAsp: 0.63 ± 0.025	0.681CysGlu: 0.681 ± 0.025	0.475CysPhe: 0.475 ± 0.019	0.952CysGly: 0.952 ± 0.03	0.366CysHis: 0.366 ± 0.018	0.562CysIle: 0.562 ± 0.021	0.426CysLys: 0.426 ± 0.018	0.982CysLeu: 0.982 ± 0.029	0.255CysMet: 0.255 ± 0.015	0.374CysAsn: 0.374 ± 0.019	0.458CysPro: 0.458 ± 0.021	0.552CysGln: 0.552 ± 0.02	0.513CysArg: 0.513 ± 0.02	0.708CysSer: 0.708 ± 0.024	0.481CysThr: 0.481 ± 0.023	0.68CysVal: 0.68 ± 0.023	0.144CysTrp: 0.144 ± 0.009	0.354CysTyr: 0.354 ± 0.016	0.0CysXaa: 0.0 ± 0.0
Asp	4.611AspAla: 4.611 ± 0.075	0.602AspCys: 0.602 ± 0.024	3.224AspAsp: 3.224 ± 0.071	3.812AspGlu: 3.812 ± 0.054	2.4AspPhe: 2.4 ± 0.046	3.902AspGly: 3.902 ± 0.073	1.275AspHis: 1.275 ± 0.039	3.886AspIle: 3.886 ± 0.059	3.185AspLys: 3.185 ± 0.047	5.009AspLeu: 5.009 ± 0.063	1.49AspMet: 1.49 ± 0.032	2.609AspAsn: 2.609 ± 0.052	2.112AspPro: 2.112 ± 0.04	2.213AspGln: 2.213 ± 0.047	2.257AspArg: 2.257 ± 0.044	3.228AspSer: 3.228 ± 0.046	2.734AspThr: 2.734 ± 0.054	3.994AspVal: 3.994 ± 0.06	0.834AspTrp: 0.834 ± 0.026	2.038AspTyr: 2.038 ± 0.038	0.001AspXaa: 0.001 ± 0.001
Glu	5.414GluAla: 5.414 ± 0.076	0.543GluCys: 0.543 ± 0.021	2.74GluAsp: 2.74 ± 0.053	3.492GluGlu: 3.492 ± 0.063	2.306GluPhe: 2.306 ± 0.037	3.644GluGly: 3.644 ± 0.068	1.621GluHis: 1.621 ± 0.041	3.488GluIle: 3.488 ± 0.051	3.511GluLys: 3.511 ± 0.06	7.038GluLeu: 7.038 ± 0.085	1.796GluMet: 1.796 ± 0.039	2.488GluAsn: 2.488 ± 0.042	2.123GluPro: 2.123 ± 0.044	4.447GluGln: 4.447 ± 0.068	3.419GluArg: 3.419 ± 0.05	3.419GluSer: 3.419 ± 0.058	3.0GluThr: 3.0 ± 0.049	4.283GluVal: 4.283 ± 0.06	0.815GluTrp: 0.815 ± 0.028	1.772GluTyr: 1.772 ± 0.036	0.0GluXaa: 0.0 ± 0.0
Phe	3.782PheAla: 3.782 ± 0.058	0.504PheCys: 0.504 ± 0.023	2.812PheAsp: 2.812 ± 0.048	2.405PheGlu: 2.405 ± 0.042	1.659PhePhe: 1.659 ± 0.036	3.133PheGly: 3.133 ± 0.051	0.832PheHis: 0.832 ± 0.022	2.62PheIle: 2.62 ± 0.048	1.855PheLys: 1.855 ± 0.039	3.292PheLeu: 3.292 ± 0.058	1.005PheMet: 1.005 ± 0.029	2.013PheAsn: 2.013 ± 0.039	1.36PhePro: 1.36 ± 0.033	1.258PheGln: 1.258 ± 0.032	1.502PheArg: 1.502 ± 0.037	3.208PheSer: 3.208 ± 0.05	2.544PheThr: 2.544 ± 0.044	2.788PheVal: 2.788 ± 0.048	0.521PheTrp: 0.521 ± 0.02	1.276PheTyr: 1.276 ± 0.034	0.0PheXaa: 0.0 ± 0.0
Gly	5.439GlyAla: 5.439 ± 0.081	0.959GlyCys: 0.959 ± 0.027	3.78GlyAsp: 3.78 ± 0.083	4.477GlyGlu: 4.477 ± 0.066	3.27GlyPhe: 3.27 ± 0.055	4.856GlyGly: 4.856 ± 0.085	1.538GlyHis: 1.538 ± 0.04	4.659GlyIle: 4.659 ± 0.067	3.961GlyLys: 3.961 ± 0.064	7.034GlyLeu: 7.034 ± 0.091	2.161GlyMet: 2.161 ± 0.041	2.702GlyAsn: 2.702 ± 0.062	1.573GlyPro: 1.573 ± 0.033	2.876GlyGln: 2.876 ± 0.047	3.062GlyArg: 3.062 ± 0.047	3.897GlySer: 3.897 ± 0.057	3.37GlyThr: 3.37 ± 0.053	5.249GlyVal: 5.249 ± 0.072	0.976GlyTrp: 0.976 ± 0.026	2.675GlyTyr: 2.675 ± 0.044	0.0GlyXaa: 0.0 ± 0.0
His	1.834HisAla: 1.834 ± 0.035	0.354HisCys: 0.354 ± 0.018	1.204HisAsp: 1.204 ± 0.033	1.149HisGlu: 1.149 ± 0.031	1.107HisPhe: 1.107 ± 0.025	1.619HisGly: 1.619 ± 0.036	0.837HisHis: 0.837 ± 0.025	1.379HisIle: 1.379 ± 0.033	0.973HisLys: 0.973 ± 0.027	2.285HisLeu: 2.285 ± 0.047	0.485HisMet: 0.485 ± 0.017	0.954HisAsn: 0.954 ± 0.025	1.161HisPro: 1.161 ± 0.031	1.458HisGln: 1.458 ± 0.034	1.124HisArg: 1.124 ± 0.029	1.455HisSer: 1.455 ± 0.035	1.141HisThr: 1.141 ± 0.029	1.252HisVal: 1.252 ± 0.035	0.39HisTrp: 0.39 ± 0.016	0.912HisTyr: 0.912 ± 0.027	0.0HisXaa: 0.0 ± 0.0
Ile	6.56IleAla: 6.56 ± 0.081	0.639IleCys: 0.639 ± 0.024	3.957IleAsp: 3.957 ± 0.059	4.369IleGlu: 4.369 ± 0.069	2.117IlePhe: 2.117 ± 0.049	4.569IleGly: 4.569 ± 0.061	1.214IleHis: 1.214 ± 0.03	3.438IleIle: 3.438 ± 0.062	3.191IleLys: 3.191 ± 0.049	4.8IleLeu: 4.8 ± 0.063	1.292IleMet: 1.292 ± 0.037	2.952IleAsn: 2.952 ± 0.05	2.575IlePro: 2.575 ± 0.046	2.179IleGln: 2.179 ± 0.044	2.618IleArg: 2.618 ± 0.045	4.166IleSer: 4.166 ± 0.061	3.789IleThr: 3.789 ± 0.061	3.887IleVal: 3.887 ± 0.054	0.58IleTrp: 0.58 ± 0.024	1.66IleTyr: 1.66 ± 0.035	0.0IleXaa: 0.0 ± 0.0
Lys	5.224LysAla: 5.224 ± 0.076	0.301LysCys: 0.301 ± 0.016	2.651LysAsp: 2.651 ± 0.048	3.057LysGlu: 3.057 ± 0.056	1.529LysPhe: 1.529 ± 0.034	3.282LysGly: 3.282 ± 0.06	1.263LysHis: 1.263 ± 0.026	2.64LysIle: 2.64 ± 0.044	2.75LysLys: 2.75 ± 0.051	5.31LysLeu: 5.31 ± 0.063	1.429LysMet: 1.429 ± 0.033	1.974LysAsn: 1.974 ± 0.034	2.44LysPro: 2.44 ± 0.045	2.946LysGln: 2.946 ± 0.049	2.469LysArg: 2.469 ± 0.049	2.905LysSer: 2.905 ± 0.047	2.673LysThr: 2.673 ± 0.048	3.928LysVal: 3.928 ± 0.054	0.535LysTrp: 0.535 ± 0.019	1.332LysTyr: 1.332 ± 0.032	0.0LysXaa: 0.0 ± 0.0
Leu	10.707LeuAla: 10.707 ± 0.098	1.095LeuCys: 1.095 ± 0.032	5.755LeuAsp: 5.755 ± 0.077	5.88LeuGlu: 5.88 ± 0.081	4.072LeuPhe: 4.072 ± 0.066	7.009LeuGly: 7.009 ± 0.085	2.072LeuHis: 2.072 ± 0.041	5.839LeuIle: 5.839 ± 0.077	5.105LeuLys: 5.105 ± 0.065	10.487LeuLeu: 10.487 ± 0.118	2.787LeuMet: 2.787 ± 0.048	4.403LeuAsn: 4.403 ± 0.054	4.868LeuPro: 4.868 ± 0.063	3.877LeuGln: 3.877 ± 0.051	4.418LeuArg: 4.418 ± 0.063	7.476LeuSer: 7.476 ± 0.081	6.324LeuThr: 6.324 ± 0.083	7.044LeuVal: 7.044 ± 0.075	1.092LeuTrp: 1.092 ± 0.03	2.588LeuTyr: 2.588 ± 0.046	0.0LeuXaa: 0.0 ± 0.0
Met	2.91MetAla: 2.91 ± 0.043	0.223MetCys: 0.223 ± 0.012	1.266MetAsp: 1.266 ± 0.033	1.321MetGlu: 1.321 ± 0.031	0.93MetPhe: 0.93 ± 0.027	1.843MetGly: 1.843 ± 0.035	0.503MetHis: 0.503 ± 0.021	1.568MetIle: 1.568 ± 0.04	1.583MetLys: 1.583 ± 0.034	2.937MetLeu: 2.937 ± 0.053	0.972MetMet: 0.972 ± 0.025	1.114MetAsn: 1.114 ± 0.028	1.355MetPro: 1.355 ± 0.029	1.129MetGln: 1.129 ± 0.031	1.174MetArg: 1.174 ± 0.029	1.934MetSer: 1.934 ± 0.038	1.841MetThr: 1.841 ± 0.031	2.041MetVal: 2.041 ± 0.04	0.235MetTrp: 0.235 ± 0.012	0.617MetTyr: 0.617 ± 0.021	0.0MetXaa: 0.0 ± 0.0
Asn	3.549AsnAla: 3.549 ± 0.046	0.406AsnCys: 0.406 ± 0.018	2.375AsnAsp: 2.375 ± 0.056	2.467AsnGlu: 2.467 ± 0.04	1.547AsnPhe: 1.547 ± 0.035	2.995AsnGly: 2.995 ± 0.054	1.039AsnHis: 1.039 ± 0.028	2.685AsnIle: 2.685 ± 0.054	2.258AsnLys: 2.258 ± 0.038	3.782AsnLeu: 3.782 ± 0.051	1.042AsnMet: 1.042 ± 0.029	2.043AsnAsn: 2.043 ± 0.041	2.065AsnPro: 2.065 ± 0.042	2.218AsnGln: 2.218 ± 0.047	1.942AsnArg: 1.942 ± 0.042	2.313AsnSer: 2.313 ± 0.045	2.401AsnThr: 2.401 ± 0.05	2.656AsnVal: 2.656 ± 0.048	0.63AsnTrp: 0.63 ± 0.021	1.402AsnTyr: 1.402 ± 0.034	0.0AsnXaa: 0.0 ± 0.0
Pro	3.564ProAla: 3.564 ± 0.058	0.347ProCys: 0.347 ± 0.018	2.341ProAsp: 2.341 ± 0.043	3.181ProGlu: 3.181 ± 0.051	1.756ProPhe: 1.756 ± 0.039	2.091ProGly: 2.091 ± 0.044	0.932ProHis: 0.932 ± 0.028	2.325ProIle: 2.325 ± 0.039	1.881ProLys: 1.881 ± 0.044	4.26ProLeu: 4.26 ± 0.06	1.088ProMet: 1.088 ± 0.025	1.669ProAsn: 1.669 ± 0.041	1.185ProPro: 1.185 ± 0.03	2.048ProGln: 2.048 ± 0.041	1.387ProArg: 1.387 ± 0.037	2.493ProSer: 2.493 ± 0.044	2.303ProThr: 2.303 ± 0.037	3.164ProVal: 3.164 ± 0.06	0.518ProTrp: 0.518 ± 0.023	1.288ProTyr: 1.288 ± 0.032	0.0ProXaa: 0.0 ± 0.0
Gln	5.211GlnAla: 5.211 ± 0.082	0.454GlnCys: 0.454 ± 0.021	2.27GlnAsp: 2.27 ± 0.043	2.5GlnGlu: 2.5 ± 0.046	1.79GlnPhe: 1.79 ± 0.037	3.397GlnGly: 3.397 ± 0.057	1.364GlnHis: 1.364 ± 0.036	2.552GlnIle: 2.552 ± 0.044	1.954GlnLys: 1.954 ± 0.036	5.756GlnLeu: 5.756 ± 0.083	1.231GlnMet: 1.231 ± 0.032	1.623GlnAsn: 1.623 ± 0.035	2.014GlnPro: 2.014 ± 0.044	3.957GlnGln: 3.957 ± 0.098	2.486GlnArg: 2.486 ± 0.052	2.776GlnSer: 2.776 ± 0.049	2.507GlnThr: 2.507 ± 0.04	3.444GlnVal: 3.444 ± 0.049	0.737GlnTrp: 0.737 ± 0.027	1.493GlnTyr: 1.493 ± 0.034	0.0GlnXaa: 0.0 ± 0.0
Arg	3.424ArgAla: 3.424 ± 0.05	0.475ArgCys: 0.475 ± 0.019	2.565ArgAsp: 2.565 ± 0.051	3.028ArgGlu: 3.028 ± 0.044	2.206ArgPhe: 2.206 ± 0.044	2.555ArgGly: 2.555 ± 0.043	1.248ArgHis: 1.248 ± 0.036	2.823ArgIle: 2.823 ± 0.051	2.191ArgLys: 2.191 ± 0.04	4.86ArgLeu: 4.86 ± 0.073	1.202ArgMet: 1.202 ± 0.029	1.83ArgAsn: 1.83 ± 0.039	1.549ArgPro: 1.549 ± 0.035	2.539ArgGln: 2.539 ± 0.049	2.423ArgArg: 2.423 ± 0.048	2.415ArgSer: 2.415 ± 0.047	2.09ArgThr: 2.09 ± 0.038	3.094ArgVal: 3.094 ± 0.044	0.661ArgTrp: 0.661 ± 0.021	1.733ArgTyr: 1.733 ± 0.035	0.0ArgXaa: 0.0 ± 0.0
Ser	5.417SerAla: 5.417 ± 0.061	0.613SerCys: 0.613 ± 0.023	3.523SerAsp: 3.523 ± 0.047	3.759SerGlu: 3.759 ± 0.066	2.719SerPhe: 2.719 ± 0.04	4.673SerGly: 4.673 ± 0.067	1.578SerHis: 1.578 ± 0.038	3.698SerIle: 3.698 ± 0.054	2.937SerLys: 2.937 ± 0.051	6.721SerLeu: 6.721 ± 0.076	1.724SerMet: 1.724 ± 0.036	2.481SerAsn: 2.481 ± 0.051	2.545SerPro: 2.545 ± 0.041	3.329SerGln: 3.329 ± 0.058	2.778SerArg: 2.778 ± 0.049	4.181SerSer: 4.181 ± 0.07	3.218SerThr: 3.218 ± 0.051	4.318SerVal: 4.318 ± 0.055	0.846SerTrp: 0.846 ± 0.025	2.003SerTyr: 2.003 ± 0.04	0.001SerXaa: 0.001 ± 0.001
Thr	4.968ThrAla: 4.968 ± 0.067	0.515ThrCys: 0.515 ± 0.018	2.934ThrAsp: 2.934 ± 0.051	3.242ThrGlu: 3.242 ± 0.044	2.17ThrPhe: 2.17 ± 0.043	3.962ThrGly: 3.962 ± 0.062	1.18ThrHis: 1.18 ± 0.029	3.338ThrIle: 3.338 ± 0.057	2.393ThrLys: 2.393 ± 0.044	6.32ThrLeu: 6.32 ± 0.073	1.295ThrMet: 1.295 ± 0.03	2.13ThrAsn: 2.13 ± 0.044	2.743ThrPro: 2.743 ± 0.046	2.654ThrGln: 2.654 ± 0.041	2.242ThrArg: 2.242 ± 0.04	3.352ThrSer: 3.352 ± 0.059	3.07ThrThr: 3.07 ± 0.056	4.038ThrVal: 4.038 ± 0.054	0.613ThrTrp: 0.613 ± 0.021	1.466ThrTyr: 1.466 ± 0.038	0.0ThrXaa: 0.0 ± 0.0
Val	6.858ValAla: 6.858 ± 0.072	0.783ValCys: 0.783 ± 0.026	4.109ValAsp: 4.109 ± 0.055	4.61ValGlu: 4.61 ± 0.065	2.773ValPhe: 2.773 ± 0.051	4.718ValGly: 4.718 ± 0.067	1.227ValHis: 1.227 ± 0.033	4.769ValIle: 4.769 ± 0.066	3.585ValLys: 3.585 ± 0.056	6.776ValLeu: 6.776 ± 0.077	2.181ValMet: 2.181 ± 0.042	2.932ValAsn: 2.932 ± 0.052	2.751ValPro: 2.751 ± 0.046	2.203ValGln: 2.203 ± 0.04	2.956ValArg: 2.956 ± 0.049	4.783ValSer: 4.783 ± 0.06	4.327ValThr: 4.327 ± 0.063	5.536ValVal: 5.536 ± 0.076	0.744ValTrp: 0.744 ± 0.024	1.784ValTyr: 1.784 ± 0.042	0.0ValXaa: 0.0 ± 0.0
Trp	0.863TrpAla: 0.863 ± 0.025	0.152TrpCys: 0.152 ± 0.01	0.625TrpAsp: 0.625 ± 0.022	0.525TrpGlu: 0.525 ± 0.022	0.583TrpPhe: 0.583 ± 0.023	0.786TrpGly: 0.786 ± 0.026	0.413TrpHis: 0.413 ± 0.017	0.631TrpIle: 0.631 ± 0.021	0.457TrpLys: 0.457 ± 0.02	1.899TrpLeu: 1.899 ± 0.045	0.337TrpMet: 0.337 ± 0.016	0.438TrpAsn: 0.438 ± 0.018	0.451TrpPro: 0.451 ± 0.017	1.129TrpGln: 1.129 ± 0.033	0.686TrpArg: 0.686 ± 0.024	0.68TrpSer: 0.68 ± 0.023	0.471TrpThr: 0.471 ± 0.02	0.873TrpVal: 0.873 ± 0.026	0.208TrpTrp: 0.208 ± 0.012	0.374TrpTyr: 0.374 ± 0.017	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.323TyrAla: 2.323 ± 0.043	0.393TyrCys: 0.393 ± 0.018	1.693TyrAsp: 1.693 ± 0.046	1.46TyrGlu: 1.46 ± 0.032	1.363TyrPhe: 1.363 ± 0.034	2.134TyrGly: 2.134 ± 0.042	0.837TyrHis: 0.837 ± 0.023	1.553TyrIle: 1.553 ± 0.037	1.287TyrLys: 1.287 ± 0.035	3.222TyrLeu: 3.222 ± 0.054	0.641TyrMet: 0.641 ± 0.018	1.178TyrAsn: 1.178 ± 0.03	1.393TyrPro: 1.393 ± 0.033	2.136TyrGln: 2.136 ± 0.04	1.765TyrArg: 1.765 ± 0.037	2.053TyrSer: 2.053 ± 0.042	1.491TyrThr: 1.491 ± 0.037	1.761TyrVal: 1.761 ± 0.039	0.476TyrTrp: 0.476 ± 0.017	1.034TyrTyr: 1.034 ± 0.03	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.001XaaHis: 0.001 ± 0.001	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.001XaaArg: 0.001 ± 0.001	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4290 proteins (1410523 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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