Amino acid dipepetide frequency for Adana virus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
6.581AlaAla: 6.581 ± 2.019
2.278AlaCys: 2.278 ± 0.488
1.266AlaAsp: 1.266 ± 0.704
4.556AlaGlu: 4.556 ± 0.999
1.772AlaPhe: 1.772 ± 0.705
3.797AlaGly: 3.797 ± 0.862
1.266AlaHis: 1.266 ± 0.718
7.846AlaIle: 7.846 ± 1.004
3.29AlaLys: 3.29 ± 0.982
5.062AlaLeu: 5.062 ± 0.734
3.037AlaMet: 3.037 ± 0.814
1.266AlaAsn: 1.266 ± 0.527
2.278AlaPro: 2.278 ± 0.348
1.772AlaGln: 1.772 ± 0.358
5.062AlaArg: 5.062 ± 1.28
2.784AlaSer: 2.784 ± 0.339
2.784AlaThr: 2.784 ± 1.105
5.062AlaVal: 5.062 ± 2.869
0.759AlaTrp: 0.759 ± 0.881
2.025AlaTyr: 2.025 ± 0.531
0.0AlaXaa: 0.0 ± 0.0
Cys
0.253CysAla: 0.253 ± 0.209
0.253CysCys: 0.253 ± 0.209
1.772CysAsp: 1.772 ± 0.358
1.772CysGlu: 1.772 ± 0.63
1.772CysPhe: 1.772 ± 0.992
1.266CysGly: 1.266 ± 0.842
0.759CysHis: 0.759 ± 0.626
1.266CysIle: 1.266 ± 0.915
2.784CysLys: 2.784 ± 0.613
2.025CysLeu: 2.025 ± 0.815
0.506CysMet: 0.506 ± 0.298
0.759CysAsn: 0.759 ± 0.337
0.759CysPro: 0.759 ± 0.221
0.506CysGln: 0.506 ± 0.418
1.266CysArg: 1.266 ± 0.329
3.037CysSer: 3.037 ± 0.592
2.278CysThr: 2.278 ± 1.005
2.278CysVal: 2.278 ± 1.005
0.0CysTrp: 0.0 ± 0.0
1.266CysTyr: 1.266 ± 0.481
0.0CysXaa: 0.0 ± 0.0
Asp
2.531AspAla: 2.531 ± 1.054
0.506AspCys: 0.506 ± 0.418
6.074AspAsp: 6.074 ± 1.085
3.037AspGlu: 3.037 ± 0.702
3.037AspPhe: 3.037 ± 0.965
2.025AspGly: 2.025 ± 0.621
1.266AspHis: 1.266 ± 0.744
3.29AspIle: 3.29 ± 1.015
2.531AspLys: 2.531 ± 0.7
6.074AspLeu: 6.074 ± 1.343
2.278AspMet: 2.278 ± 0.831
3.037AspAsn: 3.037 ± 1.061
2.531AspPro: 2.531 ± 0.608
3.037AspGln: 3.037 ± 0.673
3.037AspArg: 3.037 ± 0.779
4.303AspSer: 4.303 ± 1.298
2.025AspThr: 2.025 ± 0.391
3.037AspVal: 3.037 ± 0.36
0.759AspTrp: 0.759 ± 0.447
1.012AspTyr: 1.012 ± 0.318
0.0AspXaa: 0.0 ± 0.0
Glu
6.581GluAla: 6.581 ± 0.587
2.531GluCys: 2.531 ± 1.513
3.797GluAsp: 3.797 ± 1.221
4.809GluGlu: 4.809 ± 0.963
5.568GluPhe: 5.568 ± 1.299
4.05GluGly: 4.05 ± 1.144
1.772GluHis: 1.772 ± 0.707
3.543GluIle: 3.543 ± 1.135
2.784GluLys: 2.784 ± 0.901
5.821GluLeu: 5.821 ± 2.057
1.012GluMet: 1.012 ± 0.658
2.784GluAsn: 2.784 ± 1.402
2.278GluPro: 2.278 ± 0.823
2.278GluGln: 2.278 ± 1.079
3.29GluArg: 3.29 ± 0.997
3.037GluSer: 3.037 ± 0.68
3.037GluThr: 3.037 ± 0.538
6.074GluVal: 6.074 ± 1.479
0.506GluTrp: 0.506 ± 0.155
1.519GluTyr: 1.519 ± 0.452
0.0GluXaa: 0.0 ± 0.0
Phe
2.784PheAla: 2.784 ± 3.346
1.266PheCys: 1.266 ± 0.744
2.025PheAsp: 2.025 ± 0.374
3.543PheGlu: 3.543 ± 0.993
2.025PhePhe: 2.025 ± 0.688
2.278PheGly: 2.278 ± 0.418
0.759PheHis: 0.759 ± 0.221
2.784PheIle: 2.784 ± 0.639
2.784PheLys: 2.784 ± 0.901
4.05PheLeu: 4.05 ± 1.764
0.506PheMet: 0.506 ± 0.155
3.037PheAsn: 3.037 ± 0.848
1.266PhePro: 1.266 ± 0.606
1.012PheGln: 1.012 ± 0.785
2.531PheArg: 2.531 ± 0.953
3.797PheSer: 3.797 ± 0.046
3.29PheThr: 3.29 ± 0.642
3.037PheVal: 3.037 ± 0.738
0.506PheTrp: 0.506 ± 0.155
0.253PheTyr: 0.253 ± 0.209
0.0PheXaa: 0.0 ± 0.0
Gly
4.05GlyAla: 4.05 ± 0.831
1.519GlyCys: 1.519 ± 0.673
2.784GlyAsp: 2.784 ± 0.935
2.025GlyGlu: 2.025 ± 1.044
2.784GlyPhe: 2.784 ± 0.953
3.543GlyGly: 3.543 ± 0.455
1.519GlyHis: 1.519 ± 0.443
4.05GlyIle: 4.05 ± 0.416
2.784GlyLys: 2.784 ± 0.692
4.556GlyLeu: 4.556 ± 1.18
1.519GlyMet: 1.519 ± 0.6
2.025GlyAsn: 2.025 ± 1.286
3.543GlyPro: 3.543 ± 0.748
0.759GlyGln: 0.759 ± 0.221
3.29GlyArg: 3.29 ± 1.316
5.568GlySer: 5.568 ± 1.552
3.29GlyThr: 3.29 ± 0.434
4.556GlyVal: 4.556 ± 0.965
1.012GlyTrp: 1.012 ± 0.538
2.025GlyTyr: 2.025 ± 1.162
0.0GlyXaa: 0.0 ± 0.0
His
1.519HisAla: 1.519 ± 0.69
0.506HisCys: 0.506 ± 0.298
1.012HisAsp: 1.012 ± 0.538
1.012HisGlu: 1.012 ± 0.311
1.519HisPhe: 1.519 ± 0.31
1.266HisGly: 1.266 ± 0.352
0.506HisHis: 0.506 ± 0.155
1.519HisIle: 1.519 ± 0.443
0.759HisLys: 0.759 ± 0.221
2.025HisLeu: 2.025 ± 0.568
0.759HisMet: 0.759 ± 0.34
1.266HisAsn: 1.266 ± 0.481
1.012HisPro: 1.012 ± 0.658
1.519HisGln: 1.519 ± 0.443
1.772HisArg: 1.772 ± 0.769
2.278HisSer: 2.278 ± 0.348
1.266HisThr: 1.266 ± 0.481
1.012HisVal: 1.012 ± 0.344
0.506HisTrp: 0.506 ± 0.298
1.266HisTyr: 1.266 ± 0.481
0.0HisXaa: 0.0 ± 0.0
Ile
4.303IleAla: 4.303 ± 1.542
1.266IleCys: 1.266 ± 0.606
3.797IleAsp: 3.797 ± 0.862
3.543IleGlu: 3.543 ± 0.55
1.772IlePhe: 1.772 ± 0.567
3.797IleGly: 3.797 ± 0.745
2.278IleHis: 2.278 ± 0.664
3.543IleIle: 3.543 ± 1.361
3.29IleLys: 3.29 ± 0.594
7.593IleLeu: 7.593 ± 1.694
2.025IleMet: 2.025 ± 0.538
2.278IleAsn: 2.278 ± 0.467
3.037IlePro: 3.037 ± 1.07
1.012IleGln: 1.012 ± 0.311
3.797IleArg: 3.797 ± 0.929
5.062IleSer: 5.062 ± 1.218
3.797IleThr: 3.797 ± 1.151
5.821IleVal: 5.821 ± 1.339
0.759IleTrp: 0.759 ± 0.447
1.266IleTyr: 1.266 ± 0.744
0.0IleXaa: 0.0 ± 0.0
Lys
3.037LysAla: 3.037 ± 1.163
2.025LysCys: 2.025 ± 0.374
2.278LysAsp: 2.278 ± 0.57
2.784LysGlu: 2.784 ± 0.8
2.278LysPhe: 2.278 ± 1.079
4.303LysGly: 4.303 ± 0.714
1.012LysHis: 1.012 ± 0.344
4.809LysIle: 4.809 ± 0.697
3.037LysLys: 3.037 ± 1.12
4.809LysLeu: 4.809 ± 1.785
3.29LysMet: 3.29 ± 0.92
1.266LysAsn: 1.266 ± 0.737
3.797LysPro: 3.797 ± 1.753
1.519LysGln: 1.519 ± 0.443
2.025LysArg: 2.025 ± 0.58
4.05LysSer: 4.05 ± 1.47
2.784LysThr: 2.784 ± 0.72
5.568LysVal: 5.568 ± 0.972
2.278LysTrp: 2.278 ± 0.664
2.025LysTyr: 2.025 ± 0.538
0.0LysXaa: 0.0 ± 0.0
Leu
5.062LeuAla: 5.062 ± 1.011
2.784LeuCys: 2.784 ± 0.614
4.05LeuAsp: 4.05 ± 0.416
6.834LeuGlu: 6.834 ± 0.989
3.797LeuPhe: 3.797 ± 1.327
3.29LeuGly: 3.29 ± 1.166
2.531LeuHis: 2.531 ± 0.722
8.099LeuIle: 8.099 ± 1.348
5.315LeuLys: 5.315 ± 0.718
6.074LeuLeu: 6.074 ± 1.492
3.543LeuMet: 3.543 ± 0.716
3.037LeuAsn: 3.037 ± 0.848
3.543LeuPro: 3.543 ± 1.213
3.037LeuGln: 3.037 ± 0.45
5.821LeuArg: 5.821 ± 1.222
8.605LeuSer: 8.605 ± 0.65
4.809LeuThr: 4.809 ± 0.869
5.315LeuVal: 5.315 ± 1.287
0.253LeuTrp: 0.253 ± 0.414
2.784LeuTyr: 2.784 ± 0.622
0.0LeuXaa: 0.0 ± 0.0
Met
1.266MetAla: 1.266 ± 0.8
0.759MetCys: 0.759 ± 0.221
2.278MetAsp: 2.278 ± 1.43
2.278MetGlu: 2.278 ± 1.063
1.266MetPhe: 1.266 ± 0.481
2.025MetGly: 2.025 ± 0.696
1.012MetHis: 1.012 ± 0.562
3.037MetIle: 3.037 ± 0.7
1.772MetLys: 1.772 ± 0.567
3.037MetLeu: 3.037 ± 1.248
1.266MetMet: 1.266 ± 0.693
1.266MetAsn: 1.266 ± 0.481
1.266MetPro: 1.266 ± 0.352
1.266MetGln: 1.266 ± 0.481
1.519MetArg: 1.519 ± 1.36
2.278MetSer: 2.278 ± 0.706
2.531MetThr: 2.531 ± 0.609
1.266MetVal: 1.266 ± 0.361
0.253MetTrp: 0.253 ± 0.414
0.506MetTyr: 0.506 ± 0.155
0.0MetXaa: 0.0 ± 0.0
Asn
2.025AsnAla: 2.025 ± 0.808
0.506AsnCys: 0.506 ± 0.418
2.784AsnAsp: 2.784 ± 0.598
1.266AsnGlu: 1.266 ± 0.527
2.025AsnPhe: 2.025 ± 0.916
2.025AsnGly: 2.025 ± 0.916
0.759AsnHis: 0.759 ± 0.337
1.266AsnIle: 1.266 ± 0.481
2.278AsnLys: 2.278 ± 0.467
4.303AsnLeu: 4.303 ± 0.124
1.012AsnMet: 1.012 ± 0.596
0.759AsnAsn: 0.759 ± 0.626
2.784AsnPro: 2.784 ± 1.167
2.025AsnGln: 2.025 ± 0.857
1.266AsnArg: 1.266 ± 0.352
3.037AsnSer: 3.037 ± 0.45
2.278AsnThr: 2.278 ± 0.635
3.037AsnVal: 3.037 ± 0.609
0.506AsnTrp: 0.506 ± 0.685
0.759AsnTyr: 0.759 ± 0.337
0.0AsnXaa: 0.0 ± 0.0
Pro
3.543ProAla: 3.543 ± 0.837
1.266ProCys: 1.266 ± 1.129
2.784ProAsp: 2.784 ± 0.505
4.05ProGlu: 4.05 ± 1.066
1.519ProPhe: 1.519 ± 0.45
3.29ProGly: 3.29 ± 1.002
1.012ProHis: 1.012 ± 0.318
1.266ProIle: 1.266 ± 0.361
2.278ProLys: 2.278 ± 0.728
4.303ProLeu: 4.303 ± 0.94
1.266ProMet: 1.266 ± 0.538
1.266ProAsn: 1.266 ± 0.481
1.012ProPro: 1.012 ± 0.344
1.772ProGln: 1.772 ± 0.598
1.519ProArg: 1.519 ± 0.838
3.29ProSer: 3.29 ± 0.302
2.025ProThr: 2.025 ± 0.452
3.797ProVal: 3.797 ± 0.939
1.012ProTrp: 1.012 ± 0.502
1.266ProTyr: 1.266 ± 0.549
0.0ProXaa: 0.0 ± 0.0
Gln
2.025GlnAla: 2.025 ± 1.314
1.012GlnCys: 1.012 ± 0.311
1.772GlnAsp: 1.772 ± 0.63
2.531GlnGlu: 2.531 ± 0.515
1.519GlnPhe: 1.519 ± 0.838
1.772GlnGly: 1.772 ± 0.598
1.519GlnHis: 1.519 ± 0.624
2.531GlnIle: 2.531 ± 0.868
2.531GlnLys: 2.531 ± 0.777
3.037GlnLeu: 3.037 ± 1.028
1.519GlnMet: 1.519 ± 0.72
0.506GlnAsn: 0.506 ± 0.155
1.772GlnPro: 1.772 ± 0.843
0.253GlnGln: 0.253 ± 0.149
1.266GlnArg: 1.266 ± 0.744
1.519GlnSer: 1.519 ± 0.452
2.025GlnThr: 2.025 ± 0.621
1.266GlnVal: 1.266 ± 0.329
0.0GlnTrp: 0.0 ± 0.0
0.506GlnTyr: 0.506 ± 0.724
0.0GlnXaa: 0.0 ± 0.0
Arg
4.809ArgAla: 4.809 ± 1.416
1.519ArgCys: 1.519 ± 0.673
4.05ArgAsp: 4.05 ± 0.804
5.821ArgGlu: 5.821 ± 0.427
1.266ArgPhe: 1.266 ± 0.8
4.556ArgGly: 4.556 ± 0.781
0.759ArgHis: 0.759 ± 0.447
3.797ArgIle: 3.797 ± 1.121
3.037ArgLys: 3.037 ± 1.007
4.556ArgLeu: 4.556 ± 0.945
1.012ArgMet: 1.012 ± 0.596
1.266ArgAsn: 1.266 ± 0.704
3.037ArgPro: 3.037 ± 0.249
0.506ArgGln: 0.506 ± 0.298
2.025ArgArg: 2.025 ± 1.076
6.328ArgSer: 6.328 ± 0.896
3.543ArgThr: 3.543 ± 0.79
2.278ArgVal: 2.278 ± 0.469
0.506ArgTrp: 0.506 ± 0.392
2.278ArgTyr: 2.278 ± 0.348
0.0ArgXaa: 0.0 ± 0.0
Ser
5.062SerAla: 5.062 ± 0.908
3.29SerCys: 3.29 ± 2.128
4.05SerAsp: 4.05 ± 0.892
5.568SerGlu: 5.568 ± 0.509
3.543SerPhe: 3.543 ± 0.237
5.568SerGly: 5.568 ± 0.843
2.531SerHis: 2.531 ± 0.778
3.037SerIle: 3.037 ± 0.848
6.581SerLys: 6.581 ± 1.786
8.099SerLeu: 8.099 ± 1.228
2.025SerMet: 2.025 ± 0.696
2.025SerAsn: 2.025 ± 0.391
3.037SerPro: 3.037 ± 0.538
2.278SerGln: 2.278 ± 0.502
5.568SerArg: 5.568 ± 0.878
10.377SerSer: 10.377 ± 1.665
4.05SerThr: 4.05 ± 0.539
3.797SerVal: 3.797 ± 1.107
1.772SerTrp: 1.772 ± 0.386
1.772SerTyr: 1.772 ± 0.769
0.0SerXaa: 0.0 ± 0.0
Thr
3.29ThrAla: 3.29 ± 0.594
1.012ThrCys: 1.012 ± 0.538
2.531ThrAsp: 2.531 ± 0.722
4.303ThrGlu: 4.303 ± 0.918
2.784ThrPhe: 2.784 ± 0.613
3.543ThrGly: 3.543 ± 1.162
0.759ThrHis: 0.759 ± 0.337
4.05ThrIle: 4.05 ± 0.639
3.797ThrLys: 3.797 ± 0.892
5.568ThrLeu: 5.568 ± 1.247
1.012ThrMet: 1.012 ± 0.406
2.278ThrAsn: 2.278 ± 0.755
2.278ThrPro: 2.278 ± 0.635
1.519ThrGln: 1.519 ± 0.443
4.809ThrArg: 4.809 ± 0.735
5.568ThrSer: 5.568 ± 1.552
4.556ThrThr: 4.556 ± 1.565
2.531ThrVal: 2.531 ± 0.365
0.0ThrTrp: 0.0 ± 0.0
2.278ThrTyr: 2.278 ± 0.469
0.0ThrXaa: 0.0 ± 0.0
Val
3.29ValAla: 3.29 ± 0.583
2.278ValCys: 2.278 ± 1.005
3.797ValAsp: 3.797 ± 1.0
4.809ValGlu: 4.809 ± 1.365
2.025ValPhe: 2.025 ± 0.621
2.025ValGly: 2.025 ± 0.452
1.012ValHis: 1.012 ± 0.344
2.531ValIle: 2.531 ± 1.273
5.062ValLys: 5.062 ± 0.323
3.797ValLeu: 3.797 ± 1.35
3.037ValMet: 3.037 ± 0.437
4.05ValAsn: 4.05 ± 0.416
2.025ValPro: 2.025 ± 0.538
3.543ValGln: 3.543 ± 0.536
4.556ValArg: 4.556 ± 0.935
6.328ValSer: 6.328 ± 1.819
4.303ValThr: 4.303 ± 1.046
5.315ValVal: 5.315 ± 0.415
1.012ValTrp: 1.012 ± 0.538
1.772ValTyr: 1.772 ± 0.855
0.0ValXaa: 0.0 ± 0.0
Trp
0.759TrpAla: 0.759 ± 0.221
0.0TrpCys: 0.0 ± 0.0
0.253TrpAsp: 0.253 ± 0.209
0.759TrpGlu: 0.759 ± 0.425
0.506TrpPhe: 0.506 ± 0.155
1.012TrpGly: 1.012 ± 0.318
0.0TrpHis: 0.0 ± 0.0
0.506TrpIle: 0.506 ± 0.298
0.506TrpLys: 0.506 ± 0.685
1.266TrpLeu: 1.266 ± 0.352
0.506TrpMet: 0.506 ± 0.298
1.012TrpAsn: 1.012 ± 0.406
0.506TrpPro: 0.506 ± 0.392
0.0TrpGln: 0.0 ± 0.0
1.012TrpArg: 1.012 ± 0.785
0.759TrpSer: 0.759 ± 0.337
2.025TrpThr: 2.025 ± 0.391
0.759TrpVal: 0.759 ± 0.221
0.253TrpTrp: 0.253 ± 0.149
0.253TrpTyr: 0.253 ± 0.149
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.772TyrAla: 1.772 ± 0.559
0.0TyrCys: 0.0 ± 0.0
2.278TyrAsp: 2.278 ± 1.325
1.772TyrGlu: 1.772 ± 0.358
0.759TyrPhe: 0.759 ± 0.447
1.772TyrGly: 1.772 ± 0.419
1.266TyrHis: 1.266 ± 0.352
1.266TyrIle: 1.266 ± 0.329
1.772TyrLys: 1.772 ± 0.567
2.531TyrLeu: 2.531 ± 0.495
0.759TyrMet: 0.759 ± 0.447
1.519TyrAsn: 1.519 ± 0.443
1.772TyrPro: 1.772 ± 1.11
1.266TyrGln: 1.266 ± 0.718
1.519TyrArg: 1.519 ± 0.459
2.025TyrSer: 2.025 ± 0.815
1.772TyrThr: 1.772 ± 0.498
1.012TyrVal: 1.012 ± 0.596
0.0TyrTrp: 0.0 ± 0.0
1.012TyrTyr: 1.012 ± 0.538
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 4 proteins (3952 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski