Amino acid dipepetide frequency for Arthrobacter phage Jasmine

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
8.225AlaAla: 8.225 ± 1.06
0.558AlaCys: 0.558 ± 0.213
3.904AlaAsp: 3.904 ± 0.615
5.786AlaGlu: 5.786 ± 0.61
2.509AlaPhe: 2.509 ± 0.289
6.483AlaGly: 6.483 ± 0.74
1.952AlaHis: 1.952 ± 0.382
5.089AlaIle: 5.089 ± 0.638
5.646AlaLys: 5.646 ± 1.004
7.04AlaLeu: 7.04 ± 0.758
2.928AlaMet: 2.928 ± 0.534
5.576AlaAsn: 5.576 ± 0.867
4.113AlaPro: 4.113 ± 0.707
4.322AlaGln: 4.322 ± 0.681
4.043AlaArg: 4.043 ± 0.684
4.182AlaSer: 4.182 ± 0.581
5.507AlaThr: 5.507 ± 0.674
4.81AlaVal: 4.81 ± 0.594
1.115AlaTrp: 1.115 ± 0.282
3.346AlaTyr: 3.346 ± 0.428
0.0AlaXaa: 0.0 ± 0.0
Cys
0.488CysAla: 0.488 ± 0.209
0.07CysCys: 0.07 ± 0.082
0.209CysAsp: 0.209 ± 0.126
0.349CysGlu: 0.349 ± 0.194
0.139CysPhe: 0.139 ± 0.104
0.418CysGly: 0.418 ± 0.169
0.139CysHis: 0.139 ± 0.089
0.349CysIle: 0.349 ± 0.191
0.488CysLys: 0.488 ± 0.191
0.488CysLeu: 0.488 ± 0.193
0.349CysMet: 0.349 ± 0.149
0.418CysAsn: 0.418 ± 0.197
0.209CysPro: 0.209 ± 0.12
0.139CysGln: 0.139 ± 0.097
0.349CysArg: 0.349 ± 0.167
0.418CysSer: 0.418 ± 0.167
0.418CysThr: 0.418 ± 0.178
0.349CysVal: 0.349 ± 0.137
0.07CysTrp: 0.07 ± 0.078
0.139CysTyr: 0.139 ± 0.093
0.0CysXaa: 0.0 ± 0.0
Asp
4.949AspAla: 4.949 ± 0.458
0.139AspCys: 0.139 ± 0.104
2.928AspAsp: 2.928 ± 0.434
4.252AspGlu: 4.252 ± 0.612
2.719AspPhe: 2.719 ± 0.487
4.879AspGly: 4.879 ± 0.595
0.836AspHis: 0.836 ± 0.274
4.391AspIle: 4.391 ± 0.48
3.904AspLys: 3.904 ± 0.508
4.81AspLeu: 4.81 ± 0.757
2.021AspMet: 2.021 ± 0.454
2.649AspAsn: 2.649 ± 0.504
3.555AspPro: 3.555 ± 0.563
2.091AspGln: 2.091 ± 0.347
2.579AspArg: 2.579 ± 0.437
3.973AspSer: 3.973 ± 0.604
2.719AspThr: 2.719 ± 0.401
4.601AspVal: 4.601 ± 0.55
1.046AspTrp: 1.046 ± 0.203
1.603AspTyr: 1.603 ± 0.248
0.0AspXaa: 0.0 ± 0.0
Glu
6.343GluAla: 6.343 ± 0.893
0.767GluCys: 0.767 ± 0.282
4.113GluAsp: 4.113 ± 0.493
5.646GluGlu: 5.646 ± 1.12
3.834GluPhe: 3.834 ± 0.526
2.997GluGly: 2.997 ± 0.478
1.115GluHis: 1.115 ± 0.392
3.694GluIle: 3.694 ± 0.629
4.81GluLys: 4.81 ± 0.614
4.113GluLeu: 4.113 ± 0.651
2.509GluMet: 2.509 ± 0.429
4.322GluAsn: 4.322 ± 0.51
1.743GluPro: 1.743 ± 0.56
3.694GluGln: 3.694 ± 0.616
2.719GluArg: 2.719 ± 0.467
4.322GluSer: 4.322 ± 0.704
3.834GluThr: 3.834 ± 0.61
4.601GluVal: 4.601 ± 0.643
0.836GluTrp: 0.836 ± 0.237
2.37GluTyr: 2.37 ± 0.512
0.0GluXaa: 0.0 ± 0.0
Phe
2.3PheAla: 2.3 ± 0.419
0.279PheCys: 0.279 ± 0.168
3.346PheAsp: 3.346 ± 0.569
2.858PheGlu: 2.858 ± 0.48
1.534PhePhe: 1.534 ± 0.295
3.276PheGly: 3.276 ± 0.481
1.324PheHis: 1.324 ± 0.321
2.161PheIle: 2.161 ± 0.335
2.231PheLys: 2.231 ± 0.389
2.649PheLeu: 2.649 ± 0.434
1.115PheMet: 1.115 ± 0.299
2.161PheAsn: 2.161 ± 0.303
1.743PhePro: 1.743 ± 0.392
1.115PheGln: 1.115 ± 0.242
2.091PheArg: 2.091 ± 0.308
2.928PheSer: 2.928 ± 0.412
2.37PheThr: 2.37 ± 0.315
2.719PheVal: 2.719 ± 0.417
0.279PheTrp: 0.279 ± 0.132
1.394PheTyr: 1.394 ± 0.328
0.0PheXaa: 0.0 ± 0.0
Gly
5.298GlyAla: 5.298 ± 0.561
0.349GlyCys: 0.349 ± 0.188
4.043GlyAsp: 4.043 ± 0.721
3.206GlyGlu: 3.206 ± 0.434
4.113GlyPhe: 4.113 ± 0.512
6.971GlyGly: 6.971 ± 0.79
0.836GlyHis: 0.836 ± 0.202
4.391GlyIle: 4.391 ± 0.509
4.81GlyLys: 4.81 ± 0.786
5.646GlyLeu: 5.646 ± 0.656
2.161GlyMet: 2.161 ± 0.406
3.834GlyAsn: 3.834 ± 0.476
2.161GlyPro: 2.161 ± 0.555
2.649GlyGln: 2.649 ± 0.427
2.997GlyArg: 2.997 ± 0.5
5.576GlySer: 5.576 ± 0.648
5.576GlyThr: 5.576 ± 0.796
5.367GlyVal: 5.367 ± 0.801
1.812GlyTrp: 1.812 ± 0.271
2.649GlyTyr: 2.649 ± 0.559
0.0GlyXaa: 0.0 ± 0.0
His
1.115HisAla: 1.115 ± 0.254
0.07HisCys: 0.07 ± 0.075
1.115HisAsp: 1.115 ± 0.291
0.906HisGlu: 0.906 ± 0.295
0.697HisPhe: 0.697 ± 0.188
1.464HisGly: 1.464 ± 0.285
0.697HisHis: 0.697 ± 0.168
1.115HisIle: 1.115 ± 0.336
1.882HisLys: 1.882 ± 0.326
1.185HisLeu: 1.185 ± 0.34
0.627HisMet: 0.627 ± 0.203
1.115HisAsn: 1.115 ± 0.254
0.836HisPro: 0.836 ± 0.276
0.558HisGln: 0.558 ± 0.172
1.255HisArg: 1.255 ± 0.353
0.976HisSer: 0.976 ± 0.238
0.697HisThr: 0.697 ± 0.225
1.394HisVal: 1.394 ± 0.261
0.279HisTrp: 0.279 ± 0.164
0.418HisTyr: 0.418 ± 0.187
0.0HisXaa: 0.0 ± 0.0
Ile
5.576IleAla: 5.576 ± 0.739
0.488IleCys: 0.488 ± 0.19
3.276IleAsp: 3.276 ± 0.461
4.043IleGlu: 4.043 ± 0.558
1.812IlePhe: 1.812 ± 0.329
3.904IleGly: 3.904 ± 0.601
1.115IleHis: 1.115 ± 0.23
2.649IleIle: 2.649 ± 0.424
2.997IleLys: 2.997 ± 0.42
4.043IleLeu: 4.043 ± 0.502
1.255IleMet: 1.255 ± 0.264
3.067IleAsn: 3.067 ± 0.46
2.509IlePro: 2.509 ± 0.347
2.858IleGln: 2.858 ± 0.484
2.997IleArg: 2.997 ± 0.455
3.834IleSer: 3.834 ± 0.549
3.834IleThr: 3.834 ± 0.67
2.858IleVal: 2.858 ± 0.429
0.697IleTrp: 0.697 ± 0.228
1.812IleTyr: 1.812 ± 0.467
0.0IleXaa: 0.0 ± 0.0
Lys
6.064LysAla: 6.064 ± 0.861
0.418LysCys: 0.418 ± 0.198
3.625LysAsp: 3.625 ± 0.482
5.716LysGlu: 5.716 ± 0.869
2.091LysPhe: 2.091 ± 0.315
3.206LysGly: 3.206 ± 0.523
0.836LysHis: 0.836 ± 0.205
3.276LysIle: 3.276 ± 0.39
4.322LysLys: 4.322 ± 0.692
5.019LysLeu: 5.019 ± 0.629
1.534LysMet: 1.534 ± 0.409
3.555LysAsn: 3.555 ± 0.459
3.416LysPro: 3.416 ± 0.679
2.3LysGln: 2.3 ± 0.415
3.694LysArg: 3.694 ± 0.733
3.625LysSer: 3.625 ± 0.458
3.694LysThr: 3.694 ± 0.565
3.346LysVal: 3.346 ± 0.422
1.046LysTrp: 1.046 ± 0.264
2.37LysTyr: 2.37 ± 0.328
0.0LysXaa: 0.0 ± 0.0
Leu
8.295LeuAla: 8.295 ± 0.684
0.209LeuCys: 0.209 ± 0.118
5.716LeuAsp: 5.716 ± 0.652
4.461LeuGlu: 4.461 ± 0.684
2.021LeuPhe: 2.021 ± 0.368
6.064LeuGly: 6.064 ± 0.599
1.046LeuHis: 1.046 ± 0.233
3.973LeuIle: 3.973 ± 0.43
3.904LeuLys: 3.904 ± 0.592
4.74LeuLeu: 4.74 ± 0.772
1.603LeuMet: 1.603 ± 0.297
3.346LeuAsn: 3.346 ± 0.434
3.834LeuPro: 3.834 ± 0.395
2.928LeuGln: 2.928 ± 0.47
3.137LeuArg: 3.137 ± 0.483
5.576LeuSer: 5.576 ± 0.578
4.601LeuThr: 4.601 ± 0.585
4.322LeuVal: 4.322 ± 0.54
1.255LeuTrp: 1.255 ± 0.224
1.534LeuTyr: 1.534 ± 0.342
0.0LeuXaa: 0.0 ± 0.0
Met
2.579MetAla: 2.579 ± 0.388
0.07MetCys: 0.07 ± 0.078
1.115MetAsp: 1.115 ± 0.269
1.952MetGlu: 1.952 ± 0.386
0.906MetPhe: 0.906 ± 0.242
2.091MetGly: 2.091 ± 0.35
0.906MetHis: 0.906 ± 0.233
1.185MetIle: 1.185 ± 0.313
2.231MetLys: 2.231 ± 0.462
2.3MetLeu: 2.3 ± 0.435
0.418MetMet: 0.418 ± 0.188
0.906MetAsn: 0.906 ± 0.22
1.534MetPro: 1.534 ± 0.324
1.255MetGln: 1.255 ± 0.233
1.394MetArg: 1.394 ± 0.248
1.812MetSer: 1.812 ± 0.389
1.812MetThr: 1.812 ± 0.284
1.743MetVal: 1.743 ± 0.344
0.488MetTrp: 0.488 ± 0.174
1.046MetTyr: 1.046 ± 0.326
0.0MetXaa: 0.0 ± 0.0
Asn
4.461AsnAla: 4.461 ± 0.48
0.558AsnCys: 0.558 ± 0.211
4.182AsnAsp: 4.182 ± 0.547
3.904AsnGlu: 3.904 ± 0.489
1.952AsnPhe: 1.952 ± 0.388
4.182AsnGly: 4.182 ± 0.579
0.836AsnHis: 0.836 ± 0.204
3.485AsnIle: 3.485 ± 0.508
2.997AsnLys: 2.997 ± 0.481
3.625AsnLeu: 3.625 ± 0.359
1.743AsnMet: 1.743 ± 0.329
2.928AsnAsn: 2.928 ± 0.52
2.719AsnPro: 2.719 ± 0.348
1.882AsnGln: 1.882 ± 0.387
2.858AsnArg: 2.858 ± 0.444
3.137AsnSer: 3.137 ± 0.621
3.206AsnThr: 3.206 ± 0.616
2.928AsnVal: 2.928 ± 0.468
0.488AsnTrp: 0.488 ± 0.21
1.882AsnTyr: 1.882 ± 0.392
0.0AsnXaa: 0.0 ± 0.0
Pro
3.694ProAla: 3.694 ± 0.592
0.07ProCys: 0.07 ± 0.065
3.137ProAsp: 3.137 ± 0.534
3.973ProGlu: 3.973 ± 0.793
2.161ProPhe: 2.161 ± 0.359
2.649ProGly: 2.649 ± 0.433
0.558ProHis: 0.558 ± 0.251
2.3ProIle: 2.3 ± 0.346
2.858ProLys: 2.858 ± 0.426
2.649ProLeu: 2.649 ± 0.471
0.767ProMet: 0.767 ± 0.254
2.37ProAsn: 2.37 ± 0.393
1.882ProPro: 1.882 ± 0.692
1.882ProGln: 1.882 ± 0.311
1.743ProArg: 1.743 ± 0.316
2.579ProSer: 2.579 ± 0.4
3.555ProThr: 3.555 ± 0.596
3.346ProVal: 3.346 ± 0.49
0.418ProTrp: 0.418 ± 0.182
1.046ProTyr: 1.046 ± 0.218
0.0ProXaa: 0.0 ± 0.0
Gln
3.904GlnAla: 3.904 ± 0.564
0.07GlnCys: 0.07 ± 0.067
2.021GlnAsp: 2.021 ± 0.357
2.928GlnGlu: 2.928 ± 0.588
2.021GlnPhe: 2.021 ± 0.354
2.788GlnGly: 2.788 ± 0.377
0.488GlnHis: 0.488 ± 0.2
2.37GlnIle: 2.37 ± 0.485
3.276GlnLys: 3.276 ± 0.347
3.555GlnLeu: 3.555 ± 0.543
1.324GlnMet: 1.324 ± 0.231
1.743GlnAsn: 1.743 ± 0.367
1.394GlnPro: 1.394 ± 0.43
2.509GlnGln: 2.509 ± 0.815
2.649GlnArg: 2.649 ± 0.406
2.928GlnSer: 2.928 ± 0.443
2.649GlnThr: 2.649 ± 0.424
2.231GlnVal: 2.231 ± 0.37
0.836GlnTrp: 0.836 ± 0.253
1.324GlnTyr: 1.324 ± 0.304
0.0GlnXaa: 0.0 ± 0.0
Arg
3.346ArgAla: 3.346 ± 0.412
0.209ArgCys: 0.209 ± 0.117
2.788ArgAsp: 2.788 ± 0.466
3.137ArgGlu: 3.137 ± 0.549
2.231ArgPhe: 2.231 ± 0.431
2.858ArgGly: 2.858 ± 0.358
1.394ArgHis: 1.394 ± 0.335
3.485ArgIle: 3.485 ± 0.422
2.37ArgLys: 2.37 ± 0.516
3.485ArgLeu: 3.485 ± 0.473
1.534ArgMet: 1.534 ± 0.294
2.649ArgAsn: 2.649 ± 0.56
1.534ArgPro: 1.534 ± 0.316
2.44ArgGln: 2.44 ± 0.417
2.44ArgArg: 2.44 ± 0.504
2.509ArgSer: 2.509 ± 0.392
3.206ArgThr: 3.206 ± 0.521
2.579ArgVal: 2.579 ± 0.458
0.836ArgTrp: 0.836 ± 0.243
2.091ArgTyr: 2.091 ± 0.412
0.0ArgXaa: 0.0 ± 0.0
Ser
5.228SerAla: 5.228 ± 0.638
0.418SerCys: 0.418 ± 0.203
3.764SerAsp: 3.764 ± 0.413
4.531SerGlu: 4.531 ± 0.57
1.952SerPhe: 1.952 ± 0.366
4.391SerGly: 4.391 ± 0.523
0.558SerHis: 0.558 ± 0.221
2.928SerIle: 2.928 ± 0.558
3.834SerLys: 3.834 ± 0.595
5.507SerLeu: 5.507 ± 0.674
1.673SerMet: 1.673 ± 0.373
2.928SerAsn: 2.928 ± 0.522
3.067SerPro: 3.067 ± 0.466
2.858SerGln: 2.858 ± 0.576
2.649SerArg: 2.649 ± 0.398
4.252SerSer: 4.252 ± 0.638
3.834SerThr: 3.834 ± 0.619
4.949SerVal: 4.949 ± 0.565
1.324SerTrp: 1.324 ± 0.372
1.952SerTyr: 1.952 ± 0.505
0.0SerXaa: 0.0 ± 0.0
Thr
5.995ThrAla: 5.995 ± 0.753
0.07ThrCys: 0.07 ± 0.087
3.416ThrAsp: 3.416 ± 0.599
3.206ThrGlu: 3.206 ± 0.514
2.3ThrPhe: 2.3 ± 0.338
6.483ThrGly: 6.483 ± 0.8
1.324ThrHis: 1.324 ± 0.317
3.485ThrIle: 3.485 ± 0.525
3.485ThrLys: 3.485 ± 0.542
4.182ThrLeu: 4.182 ± 0.723
1.464ThrMet: 1.464 ± 0.356
3.973ThrAsn: 3.973 ± 0.694
3.206ThrPro: 3.206 ± 0.349
2.44ThrGln: 2.44 ± 0.452
2.231ThrArg: 2.231 ± 0.355
3.555ThrSer: 3.555 ± 0.529
5.158ThrThr: 5.158 ± 0.852
4.461ThrVal: 4.461 ± 0.738
0.906ThrTrp: 0.906 ± 0.185
2.231ThrTyr: 2.231 ± 0.507
0.0ThrXaa: 0.0 ± 0.0
Val
5.158ValAla: 5.158 ± 0.574
0.488ValCys: 0.488 ± 0.19
4.601ValAsp: 4.601 ± 0.524
4.461ValGlu: 4.461 ± 0.612
2.509ValPhe: 2.509 ± 0.461
5.786ValGly: 5.786 ± 0.793
1.324ValHis: 1.324 ± 0.334
2.719ValIle: 2.719 ± 0.449
4.322ValLys: 4.322 ± 0.487
3.555ValLeu: 3.555 ± 0.532
1.603ValMet: 1.603 ± 0.42
3.276ValAsn: 3.276 ± 0.529
2.44ValPro: 2.44 ± 0.447
2.719ValGln: 2.719 ± 0.343
3.206ValArg: 3.206 ± 0.603
3.904ValSer: 3.904 ± 0.523
4.601ValThr: 4.601 ± 0.736
4.391ValVal: 4.391 ± 0.597
0.697ValTrp: 0.697 ± 0.259
1.812ValTyr: 1.812 ± 0.42
0.0ValXaa: 0.0 ± 0.0
Trp
1.394TrpAla: 1.394 ± 0.292
0.139TrpCys: 0.139 ± 0.109
0.976TrpAsp: 0.976 ± 0.309
0.976TrpGlu: 0.976 ± 0.284
0.349TrpPhe: 0.349 ± 0.165
1.324TrpGly: 1.324 ± 0.354
0.558TrpHis: 0.558 ± 0.198
1.046TrpIle: 1.046 ± 0.306
1.046TrpLys: 1.046 ± 0.31
1.115TrpLeu: 1.115 ± 0.264
0.139TrpMet: 0.139 ± 0.094
1.185TrpAsn: 1.185 ± 0.299
0.627TrpPro: 0.627 ± 0.213
0.767TrpGln: 0.767 ± 0.232
0.697TrpArg: 0.697 ± 0.262
0.836TrpSer: 0.836 ± 0.23
0.697TrpThr: 0.697 ± 0.215
0.767TrpVal: 0.767 ± 0.194
0.349TrpTrp: 0.349 ± 0.157
0.558TrpTyr: 0.558 ± 0.183
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.719TyrAla: 2.719 ± 0.312
0.558TyrCys: 0.558 ± 0.203
2.37TyrAsp: 2.37 ± 0.452
2.091TyrGlu: 2.091 ± 0.393
2.021TyrPhe: 2.021 ± 0.536
2.231TyrGly: 2.231 ± 0.403
0.558TyrHis: 0.558 ± 0.175
1.534TyrIle: 1.534 ± 0.4
1.812TyrLys: 1.812 ± 0.347
2.858TyrLeu: 2.858 ± 0.533
0.906TyrMet: 0.906 ± 0.202
1.952TyrAsn: 1.952 ± 0.36
1.115TyrPro: 1.115 ± 0.313
1.603TyrGln: 1.603 ± 0.32
1.394TyrArg: 1.394 ± 0.307
1.673TyrSer: 1.673 ± 0.407
1.603TyrThr: 1.603 ± 0.356
1.812TyrVal: 1.812 ± 0.373
0.767TyrTrp: 0.767 ± 0.225
1.464TyrTyr: 1.464 ± 0.285
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 56 proteins (14347 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski