Amino acid dipepetide frequency for Streptococcus phage Javan105

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
4.154AlaAla: 4.154 ± 0.707
0.662AlaCys: 0.662 ± 0.184
4.215AlaAsp: 4.215 ± 0.601
4.154AlaGlu: 4.154 ± 0.514
2.77AlaPhe: 2.77 ± 0.458
5.298AlaGly: 5.298 ± 0.636
0.903AlaHis: 0.903 ± 0.222
5.599AlaIle: 5.599 ± 0.988
5.118AlaLys: 5.118 ± 0.466
4.937AlaLeu: 4.937 ± 0.733
1.445AlaMet: 1.445 ± 0.324
3.191AlaAsn: 3.191 ± 0.476
1.385AlaPro: 1.385 ± 0.289
2.288AlaGln: 2.288 ± 0.347
2.95AlaArg: 2.95 ± 0.499
3.492AlaSer: 3.492 ± 0.452
2.469AlaThr: 2.469 ± 0.41
3.673AlaVal: 3.673 ± 0.508
0.602AlaTrp: 0.602 ± 0.177
2.709AlaTyr: 2.709 ± 0.464
0.0AlaXaa: 0.0 ± 0.0
Cys
0.301CysAla: 0.301 ± 0.127
0.361CysCys: 0.361 ± 0.14
0.722CysAsp: 0.722 ± 0.182
0.963CysGlu: 0.963 ± 0.244
0.602CysPhe: 0.602 ± 0.164
1.024CysGly: 1.024 ± 0.251
0.06CysHis: 0.06 ± 0.062
0.602CysIle: 0.602 ± 0.166
0.843CysLys: 0.843 ± 0.197
1.024CysLeu: 1.024 ± 0.262
0.12CysMet: 0.12 ± 0.117
0.602CysAsn: 0.602 ± 0.162
0.482CysPro: 0.482 ± 0.135
0.421CysGln: 0.421 ± 0.155
0.602CysArg: 0.602 ± 0.197
0.662CysSer: 0.662 ± 0.175
0.783CysThr: 0.783 ± 0.245
0.722CysVal: 0.722 ± 0.229
0.06CysTrp: 0.06 ± 0.051
0.662CysTyr: 0.662 ± 0.185
0.0CysXaa: 0.0 ± 0.0
Asp
4.395AspAla: 4.395 ± 0.478
0.843AspCys: 0.843 ± 0.222
2.83AspAsp: 2.83 ± 0.602
5.539AspGlu: 5.539 ± 0.604
3.01AspPhe: 3.01 ± 0.402
4.756AspGly: 4.756 ± 0.55
0.843AspHis: 0.843 ± 0.231
5.78AspIle: 5.78 ± 0.501
5.9AspLys: 5.9 ± 0.439
4.696AspLeu: 4.696 ± 0.624
1.505AspMet: 1.505 ± 0.287
2.77AspAsn: 2.77 ± 0.452
1.927AspPro: 1.927 ± 0.26
0.602AspGln: 0.602 ± 0.167
3.311AspArg: 3.311 ± 0.42
3.432AspSer: 3.432 ± 0.42
3.071AspThr: 3.071 ± 0.52
3.191AspVal: 3.191 ± 0.455
0.903AspTrp: 0.903 ± 0.18
2.469AspTyr: 2.469 ± 0.471
0.0AspXaa: 0.0 ± 0.0
Glu
3.612GluAla: 3.612 ± 0.422
0.903GluCys: 0.903 ± 0.184
4.154GluAsp: 4.154 ± 0.466
7.586GluGlu: 7.586 ± 0.911
3.01GluPhe: 3.01 ± 0.559
5.057GluGly: 5.057 ± 0.555
0.963GluHis: 0.963 ± 0.232
7.526GluIle: 7.526 ± 0.705
8.309GluLys: 8.309 ± 0.624
8.128GluLeu: 8.128 ± 0.552
3.071GluMet: 3.071 ± 0.435
5.298GluAsn: 5.298 ± 0.61
1.565GluPro: 1.565 ± 0.344
2.288GluGln: 2.288 ± 0.361
3.191GluArg: 3.191 ± 0.588
3.733GluSer: 3.733 ± 0.471
3.673GluThr: 3.673 ± 0.476
5.479GluVal: 5.479 ± 0.648
0.963GluTrp: 0.963 ± 0.201
3.191GluTyr: 3.191 ± 0.448
0.0GluXaa: 0.0 ± 0.0
Phe
2.529PheAla: 2.529 ± 0.376
0.421PheCys: 0.421 ± 0.163
3.251PheAsp: 3.251 ± 0.401
3.372PheGlu: 3.372 ± 0.395
1.204PhePhe: 1.204 ± 0.26
2.649PheGly: 2.649 ± 0.424
0.783PheHis: 0.783 ± 0.24
3.071PheIle: 3.071 ± 0.432
3.612PheLys: 3.612 ± 0.451
3.191PheLeu: 3.191 ± 0.413
1.024PheMet: 1.024 ± 0.216
2.167PheAsn: 2.167 ± 0.35
1.144PhePro: 1.144 ± 0.271
0.783PheGln: 0.783 ± 0.183
1.927PheArg: 1.927 ± 0.36
2.408PheSer: 2.408 ± 0.26
1.626PheThr: 1.626 ± 0.279
2.469PheVal: 2.469 ± 0.376
0.482PheTrp: 0.482 ± 0.172
1.806PheTyr: 1.806 ± 0.321
0.0PheXaa: 0.0 ± 0.0
Gly
3.914GlyAla: 3.914 ± 0.733
0.662GlyCys: 0.662 ± 0.175
3.552GlyAsp: 3.552 ± 0.528
4.275GlyGlu: 4.275 ± 0.384
2.408GlyPhe: 2.408 ± 0.389
4.275GlyGly: 4.275 ± 0.655
1.204GlyHis: 1.204 ± 0.264
5.118GlyIle: 5.118 ± 0.402
6.924GlyLys: 6.924 ± 0.572
5.479GlyLeu: 5.479 ± 0.586
1.927GlyMet: 1.927 ± 0.292
3.673GlyAsn: 3.673 ± 0.583
0.783GlyPro: 0.783 ± 0.233
1.264GlyGln: 1.264 ± 0.273
2.709GlyArg: 2.709 ± 0.447
3.071GlySer: 3.071 ± 0.527
4.335GlyThr: 4.335 ± 0.497
3.612GlyVal: 3.612 ± 0.537
0.662GlyTrp: 0.662 ± 0.173
2.77GlyTyr: 2.77 ± 0.383
0.0GlyXaa: 0.0 ± 0.0
His
0.783HisAla: 0.783 ± 0.228
0.0HisCys: 0.0 ± 0.0
0.903HisAsp: 0.903 ± 0.242
0.843HisGlu: 0.843 ± 0.248
0.602HisPhe: 0.602 ± 0.157
1.325HisGly: 1.325 ± 0.259
0.482HisHis: 0.482 ± 0.15
1.325HisIle: 1.325 ± 0.26
1.144HisLys: 1.144 ± 0.305
1.746HisLeu: 1.746 ± 0.273
0.301HisMet: 0.301 ± 0.109
0.662HisAsn: 0.662 ± 0.219
0.903HisPro: 0.903 ± 0.203
0.482HisGln: 0.482 ± 0.164
0.662HisArg: 0.662 ± 0.189
1.084HisSer: 1.084 ± 0.237
0.662HisThr: 0.662 ± 0.207
0.903HisVal: 0.903 ± 0.199
0.181HisTrp: 0.181 ± 0.096
0.843HisTyr: 0.843 ± 0.215
0.0HisXaa: 0.0 ± 0.0
Ile
5.78IleAla: 5.78 ± 0.583
1.264IleCys: 1.264 ± 0.254
5.359IleAsp: 5.359 ± 0.541
7.105IleGlu: 7.105 ± 0.712
3.853IlePhe: 3.853 ± 0.354
3.673IleGly: 3.673 ± 0.526
1.264IleHis: 1.264 ± 0.231
5.298IleIle: 5.298 ± 0.662
7.044IleLys: 7.044 ± 0.784
6.382IleLeu: 6.382 ± 0.643
1.746IleMet: 1.746 ± 0.423
4.756IleAsn: 4.756 ± 0.628
2.649IlePro: 2.649 ± 0.419
2.167IleGln: 2.167 ± 0.38
3.372IleArg: 3.372 ± 0.574
5.84IleSer: 5.84 ± 0.553
4.636IleThr: 4.636 ± 0.534
3.793IleVal: 3.793 ± 0.475
1.445IleTrp: 1.445 ± 0.335
2.709IleTyr: 2.709 ± 0.361
0.0IleXaa: 0.0 ± 0.0
Lys
5.66LysAla: 5.66 ± 0.504
1.204LysCys: 1.204 ± 0.239
6.382LysAsp: 6.382 ± 0.581
8.128LysGlu: 8.128 ± 0.646
3.492LysPhe: 3.492 ± 0.463
4.997LysGly: 4.997 ± 0.505
0.963LysHis: 0.963 ± 0.208
6.924LysIle: 6.924 ± 0.613
7.526LysLys: 7.526 ± 0.697
7.105LysLeu: 7.105 ± 0.681
1.927LysMet: 1.927 ± 0.372
3.914LysAsn: 3.914 ± 0.469
3.131LysPro: 3.131 ± 0.476
3.612LysGln: 3.612 ± 0.473
3.673LysArg: 3.673 ± 0.522
5.9LysSer: 5.9 ± 0.529
4.275LysThr: 4.275 ± 0.668
5.419LysVal: 5.419 ± 0.406
1.264LysTrp: 1.264 ± 0.316
3.914LysTyr: 3.914 ± 0.549
0.0LysXaa: 0.0 ± 0.0
Leu
4.455LeuAla: 4.455 ± 0.669
0.843LeuCys: 0.843 ± 0.225
5.539LeuAsp: 5.539 ± 0.658
7.767LeuGlu: 7.767 ± 0.878
3.071LeuPhe: 3.071 ± 0.418
4.997LeuGly: 4.997 ± 0.562
0.903LeuHis: 0.903 ± 0.227
6.864LeuIle: 6.864 ± 0.842
6.563LeuLys: 6.563 ± 0.672
6.924LeuLeu: 6.924 ± 0.545
2.348LeuMet: 2.348 ± 0.466
4.094LeuAsn: 4.094 ± 0.454
2.95LeuPro: 2.95 ± 0.384
2.709LeuGln: 2.709 ± 0.467
3.071LeuArg: 3.071 ± 0.405
7.526LeuSer: 7.526 ± 0.614
3.974LeuThr: 3.974 ± 0.472
4.756LeuVal: 4.756 ± 0.518
0.542LeuTrp: 0.542 ± 0.148
3.492LeuTyr: 3.492 ± 0.553
0.0LeuXaa: 0.0 ± 0.0
Met
1.565MetAla: 1.565 ± 0.277
0.361MetCys: 0.361 ± 0.15
1.866MetAsp: 1.866 ± 0.389
2.228MetGlu: 2.228 ± 0.317
0.783MetPhe: 0.783 ± 0.253
1.505MetGly: 1.505 ± 0.335
0.181MetHis: 0.181 ± 0.107
1.565MetIle: 1.565 ± 0.313
2.649MetLys: 2.649 ± 0.32
2.047MetLeu: 2.047 ± 0.342
0.602MetMet: 0.602 ± 0.179
1.927MetAsn: 1.927 ± 0.293
0.722MetPro: 0.722 ± 0.188
0.722MetGln: 0.722 ± 0.211
1.024MetArg: 1.024 ± 0.231
2.047MetSer: 2.047 ± 0.291
1.565MetThr: 1.565 ± 0.36
1.626MetVal: 1.626 ± 0.274
0.241MetTrp: 0.241 ± 0.115
1.084MetTyr: 1.084 ± 0.307
0.0MetXaa: 0.0 ± 0.0
Asn
4.335AsnAla: 4.335 ± 0.554
0.602AsnCys: 0.602 ± 0.202
3.372AsnAsp: 3.372 ± 0.505
3.974AsnGlu: 3.974 ± 0.622
1.987AsnPhe: 1.987 ± 0.419
5.178AsnGly: 5.178 ± 0.58
1.264AsnHis: 1.264 ± 0.288
4.696AsnIle: 4.696 ± 0.54
4.455AsnLys: 4.455 ± 0.446
3.853AsnLeu: 3.853 ± 0.436
1.325AsnMet: 1.325 ± 0.23
2.469AsnAsn: 2.469 ± 0.355
1.866AsnPro: 1.866 ± 0.31
1.686AsnGln: 1.686 ± 0.32
2.77AsnArg: 2.77 ± 0.462
3.492AsnSer: 3.492 ± 0.632
3.01AsnThr: 3.01 ± 0.427
2.709AsnVal: 2.709 ± 0.357
0.301AsnTrp: 0.301 ± 0.158
1.927AsnTyr: 1.927 ± 0.402
0.0AsnXaa: 0.0 ± 0.0
Pro
1.024ProAla: 1.024 ± 0.198
0.421ProCys: 0.421 ± 0.216
1.626ProAsp: 1.626 ± 0.26
2.348ProGlu: 2.348 ± 0.369
1.626ProPhe: 1.626 ± 0.248
1.084ProGly: 1.084 ± 0.234
0.662ProHis: 0.662 ± 0.223
2.228ProIle: 2.228 ± 0.423
2.348ProLys: 2.348 ± 0.43
1.626ProLeu: 1.626 ± 0.292
1.084ProMet: 1.084 ± 0.243
2.047ProAsn: 2.047 ± 0.344
1.204ProPro: 1.204 ± 0.216
1.204ProGln: 1.204 ± 0.23
1.144ProArg: 1.144 ± 0.232
2.288ProSer: 2.288 ± 0.304
2.047ProThr: 2.047 ± 0.328
1.505ProVal: 1.505 ± 0.248
0.361ProTrp: 0.361 ± 0.16
1.866ProTyr: 1.866 ± 0.341
0.0ProXaa: 0.0 ± 0.0
Gln
2.348GlnAla: 2.348 ± 0.303
0.421GlnCys: 0.421 ± 0.148
1.325GlnAsp: 1.325 ± 0.305
2.047GlnGlu: 2.047 ± 0.427
1.144GlnPhe: 1.144 ± 0.184
1.385GlnGly: 1.385 ± 0.277
0.662GlnHis: 0.662 ± 0.216
2.408GlnIle: 2.408 ± 0.372
3.251GlnLys: 3.251 ± 0.393
2.167GlnLeu: 2.167 ± 0.424
1.204GlnMet: 1.204 ± 0.275
2.047GlnAsn: 2.047 ± 0.303
1.204GlnPro: 1.204 ± 0.241
1.325GlnGln: 1.325 ± 0.28
1.204GlnArg: 1.204 ± 0.267
1.385GlnSer: 1.385 ± 0.34
0.963GlnThr: 0.963 ± 0.258
1.746GlnVal: 1.746 ± 0.29
0.482GlnTrp: 0.482 ± 0.172
0.783GlnTyr: 0.783 ± 0.199
0.0GlnXaa: 0.0 ± 0.0
Arg
2.589ArgAla: 2.589 ± 0.386
0.662ArgCys: 0.662 ± 0.169
2.529ArgAsp: 2.529 ± 0.414
3.311ArgGlu: 3.311 ± 0.321
1.626ArgPhe: 1.626 ± 0.287
1.626ArgGly: 1.626 ± 0.292
0.542ArgHis: 0.542 ± 0.169
3.492ArgIle: 3.492 ± 0.582
4.094ArgLys: 4.094 ± 0.452
3.492ArgLeu: 3.492 ± 0.385
1.746ArgMet: 1.746 ± 0.271
2.228ArgAsn: 2.228 ± 0.382
1.144ArgPro: 1.144 ± 0.255
1.626ArgGln: 1.626 ± 0.363
1.866ArgArg: 1.866 ± 0.476
2.167ArgSer: 2.167 ± 0.345
2.649ArgThr: 2.649 ± 0.408
2.95ArgVal: 2.95 ± 0.437
0.662ArgTrp: 0.662 ± 0.23
1.385ArgTyr: 1.385 ± 0.267
0.0ArgXaa: 0.0 ± 0.0
Ser
4.455SerAla: 4.455 ± 0.569
0.301SerCys: 0.301 ± 0.124
4.215SerAsp: 4.215 ± 0.542
4.636SerGlu: 4.636 ± 0.461
2.469SerPhe: 2.469 ± 0.342
4.817SerGly: 4.817 ± 0.476
1.264SerHis: 1.264 ± 0.3
5.298SerIle: 5.298 ± 0.659
5.057SerLys: 5.057 ± 0.634
5.961SerLeu: 5.961 ± 0.597
1.866SerMet: 1.866 ± 0.491
3.131SerAsn: 3.131 ± 0.386
1.686SerPro: 1.686 ± 0.282
1.686SerGln: 1.686 ± 0.297
1.866SerArg: 1.866 ± 0.284
5.66SerSer: 5.66 ± 0.92
3.492SerThr: 3.492 ± 0.467
3.793SerVal: 3.793 ± 0.472
0.963SerTrp: 0.963 ± 0.264
2.649SerTyr: 2.649 ± 0.574
0.0SerXaa: 0.0 ± 0.0
Thr
3.311ThrAla: 3.311 ± 0.657
0.301ThrCys: 0.301 ± 0.156
3.01ThrAsp: 3.01 ± 0.502
4.034ThrGlu: 4.034 ± 0.447
1.565ThrPhe: 1.565 ± 0.329
3.131ThrGly: 3.131 ± 0.398
1.024ThrHis: 1.024 ± 0.235
4.817ThrIle: 4.817 ± 0.52
4.576ThrLys: 4.576 ± 0.614
4.395ThrLeu: 4.395 ± 0.505
1.144ThrMet: 1.144 ± 0.235
3.191ThrAsn: 3.191 ± 0.433
1.806ThrPro: 1.806 ± 0.323
0.843ThrGln: 0.843 ± 0.201
1.806ThrArg: 1.806 ± 0.375
3.853ThrSer: 3.853 ± 0.54
2.83ThrThr: 2.83 ± 0.463
3.793ThrVal: 3.793 ± 0.726
0.421ThrTrp: 0.421 ± 0.134
1.866ThrTyr: 1.866 ± 0.291
0.0ThrXaa: 0.0 ± 0.0
Val
3.432ValAla: 3.432 ± 0.441
0.482ValCys: 0.482 ± 0.143
4.215ValAsp: 4.215 ± 0.416
4.636ValGlu: 4.636 ± 0.516
2.228ValPhe: 2.228 ± 0.426
2.408ValGly: 2.408 ± 0.574
0.843ValHis: 0.843 ± 0.221
4.154ValIle: 4.154 ± 0.616
5.057ValLys: 5.057 ± 0.626
5.359ValLeu: 5.359 ± 0.506
0.843ValMet: 0.843 ± 0.205
3.793ValAsn: 3.793 ± 0.446
1.686ValPro: 1.686 ± 0.269
1.866ValGln: 1.866 ± 0.336
2.89ValArg: 2.89 ± 0.378
4.094ValSer: 4.094 ± 0.526
3.131ValThr: 3.131 ± 0.37
3.372ValVal: 3.372 ± 0.409
0.843ValTrp: 0.843 ± 0.257
2.89ValTyr: 2.89 ± 0.453
0.0ValXaa: 0.0 ± 0.0
Trp
0.662TrpAla: 0.662 ± 0.191
0.301TrpCys: 0.301 ± 0.168
0.602TrpAsp: 0.602 ± 0.187
1.024TrpGlu: 1.024 ± 0.273
0.482TrpPhe: 0.482 ± 0.168
0.722TrpGly: 0.722 ± 0.214
0.482TrpHis: 0.482 ± 0.177
0.301TrpIle: 0.301 ± 0.149
0.783TrpLys: 0.783 ± 0.201
1.204TrpLeu: 1.204 ± 0.241
0.421TrpMet: 0.421 ± 0.134
0.843TrpAsn: 0.843 ± 0.244
0.12TrpPro: 0.12 ± 0.077
0.421TrpGln: 0.421 ± 0.157
0.662TrpArg: 0.662 ± 0.163
0.722TrpSer: 0.722 ± 0.168
0.421TrpThr: 0.421 ± 0.145
0.783TrpVal: 0.783 ± 0.239
0.06TrpTrp: 0.06 ± 0.058
0.662TrpTyr: 0.662 ± 0.187
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.709TyrAla: 2.709 ± 0.43
0.602TyrCys: 0.602 ± 0.17
2.107TyrAsp: 2.107 ± 0.352
3.733TyrGlu: 3.733 ± 0.489
1.987TyrPhe: 1.987 ± 0.343
2.709TyrGly: 2.709 ± 0.426
0.542TyrHis: 0.542 ± 0.185
3.131TyrIle: 3.131 ± 0.453
4.154TyrLys: 4.154 ± 0.511
3.673TyrLeu: 3.673 ± 0.508
0.602TyrMet: 0.602 ± 0.193
2.469TyrAsn: 2.469 ± 0.445
1.385TyrPro: 1.385 ± 0.276
1.505TyrGln: 1.505 ± 0.221
1.686TyrArg: 1.686 ± 0.312
2.408TyrSer: 2.408 ± 0.363
2.107TyrThr: 2.107 ± 0.453
1.927TyrVal: 1.927 ± 0.348
0.241TyrTrp: 0.241 ± 0.106
1.806TyrTyr: 1.806 ± 0.432
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 65 proteins (16610 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski