Amino acid dipepetide frequency for Klebsiella phage ST512-KPC3phi13.3

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
12.572AlaAla: 12.572 ± 1.034
1.004AlaCys: 1.004 ± 0.222
7.184AlaAsp: 7.184 ± 0.601
6.075AlaGlu: 6.075 ± 0.682
2.747AlaPhe: 2.747 ± 0.34
7.712AlaGly: 7.712 ± 0.808
1.585AlaHis: 1.585 ± 0.279
3.803AlaIle: 3.803 ± 0.45
4.226AlaLys: 4.226 ± 0.427
9.138AlaLeu: 9.138 ± 0.958
4.437AlaMet: 4.437 ± 0.577
3.75AlaAsn: 3.75 ± 0.58
3.698AlaPro: 3.698 ± 0.722
4.701AlaGln: 4.701 ± 0.509
6.656AlaArg: 6.656 ± 0.683
5.441AlaSer: 5.441 ± 0.757
4.437AlaThr: 4.437 ± 0.457
6.18AlaVal: 6.18 ± 0.647
1.479AlaTrp: 1.479 ± 0.362
3.011AlaTyr: 3.011 ± 0.45
0.0AlaXaa: 0.0 ± 0.0
Cys
1.321CysAla: 1.321 ± 0.282
0.053CysCys: 0.053 ± 0.052
0.792CysAsp: 0.792 ± 0.229
0.634CysGlu: 0.634 ± 0.179
0.317CysPhe: 0.317 ± 0.136
0.792CysGly: 0.792 ± 0.239
0.423CysHis: 0.423 ± 0.183
0.264CysIle: 0.264 ± 0.13
0.528CysLys: 0.528 ± 0.196
0.634CysLeu: 0.634 ± 0.18
0.317CysMet: 0.317 ± 0.136
0.581CysAsn: 0.581 ± 0.228
0.634CysPro: 0.634 ± 0.196
0.475CysGln: 0.475 ± 0.16
0.687CysArg: 0.687 ± 0.268
0.898CysSer: 0.898 ± 0.237
0.423CysThr: 0.423 ± 0.14
0.687CysVal: 0.687 ± 0.185
0.264CysTrp: 0.264 ± 0.108
0.211CysTyr: 0.211 ± 0.103
0.0CysXaa: 0.0 ± 0.0
Asp
6.022AspAla: 6.022 ± 0.553
0.74AspCys: 0.74 ± 0.227
3.381AspAsp: 3.381 ± 0.426
4.543AspGlu: 4.543 ± 0.469
2.43AspPhe: 2.43 ± 0.441
5.335AspGly: 5.335 ± 0.724
1.109AspHis: 1.109 ± 0.209
3.117AspIle: 3.117 ± 0.463
2.588AspLys: 2.588 ± 0.3
4.754AspLeu: 4.754 ± 0.39
1.268AspMet: 1.268 ± 0.261
1.849AspAsn: 1.849 ± 0.291
2.905AspPro: 2.905 ± 0.38
2.694AspGln: 2.694 ± 0.364
3.275AspArg: 3.275 ± 0.47
3.169AspSer: 3.169 ± 0.468
2.852AspThr: 2.852 ± 0.391
4.384AspVal: 4.384 ± 0.452
0.581AspTrp: 0.581 ± 0.153
1.954AspTyr: 1.954 ± 0.342
0.0AspXaa: 0.0 ± 0.0
Glu
6.286GluAla: 6.286 ± 0.646
0.634GluCys: 0.634 ± 0.158
3.328GluAsp: 3.328 ± 0.486
3.698GluGlu: 3.698 ± 0.537
2.219GluPhe: 2.219 ± 0.337
3.592GluGly: 3.592 ± 0.525
1.004GluHis: 1.004 ± 0.25
4.067GluIle: 4.067 ± 0.502
3.592GluLys: 3.592 ± 0.506
5.335GluLeu: 5.335 ± 0.632
1.796GluMet: 1.796 ± 0.336
2.377GluAsn: 2.377 ± 0.339
2.588GluPro: 2.588 ± 0.384
3.698GluGln: 3.698 ± 0.415
4.701GluArg: 4.701 ± 0.532
2.905GluSer: 2.905 ± 0.391
2.641GluThr: 2.641 ± 0.388
3.909GluVal: 3.909 ± 0.471
0.845GluTrp: 0.845 ± 0.201
1.954GluTyr: 1.954 ± 0.288
0.0GluXaa: 0.0 ± 0.0
Phe
3.592PheAla: 3.592 ± 0.352
0.423PheCys: 0.423 ± 0.137
2.271PheAsp: 2.271 ± 0.34
1.954PheGlu: 1.954 ± 0.309
1.004PhePhe: 1.004 ± 0.307
2.694PheGly: 2.694 ± 0.44
0.581PheHis: 0.581 ± 0.144
2.641PheIle: 2.641 ± 0.326
1.954PheLys: 1.954 ± 0.299
1.902PheLeu: 1.902 ± 0.323
0.475PheMet: 0.475 ± 0.178
1.902PheAsn: 1.902 ± 0.307
1.321PhePro: 1.321 ± 0.241
1.004PheGln: 1.004 ± 0.244
1.585PheArg: 1.585 ± 0.254
2.166PheSer: 2.166 ± 0.31
2.113PheThr: 2.113 ± 0.316
2.113PheVal: 2.113 ± 0.372
0.581PheTrp: 0.581 ± 0.154
1.373PheTyr: 1.373 ± 0.324
0.0PheXaa: 0.0 ± 0.0
Gly
5.124GlyAla: 5.124 ± 0.747
0.951GlyCys: 0.951 ± 0.256
3.909GlyAsp: 3.909 ± 0.383
5.335GlyGlu: 5.335 ± 0.535
3.064GlyPhe: 3.064 ± 0.429
6.814GlyGly: 6.814 ± 0.664
1.585GlyHis: 1.585 ± 0.271
4.49GlyIle: 4.49 ± 0.493
4.173GlyLys: 4.173 ± 0.498
7.131GlyLeu: 7.131 ± 0.512
2.007GlyMet: 2.007 ± 0.367
3.592GlyAsn: 3.592 ± 0.446
1.585GlyPro: 1.585 ± 0.258
3.434GlyGln: 3.434 ± 0.456
5.124GlyArg: 5.124 ± 0.545
4.49GlySer: 4.49 ± 0.562
3.486GlyThr: 3.486 ± 0.392
4.86GlyVal: 4.86 ± 0.544
1.69GlyTrp: 1.69 ± 0.322
2.641GlyTyr: 2.641 ± 0.333
0.0GlyXaa: 0.0 ± 0.0
His
1.268HisAla: 1.268 ± 0.264
0.423HisCys: 0.423 ± 0.139
1.109HisAsp: 1.109 ± 0.258
1.321HisGlu: 1.321 ± 0.283
0.898HisPhe: 0.898 ± 0.23
1.954HisGly: 1.954 ± 0.36
0.264HisHis: 0.264 ± 0.103
0.845HisIle: 0.845 ± 0.209
0.581HisLys: 0.581 ± 0.175
2.007HisLeu: 2.007 ± 0.361
0.37HisMet: 0.37 ± 0.151
0.74HisAsn: 0.74 ± 0.2
1.215HisPro: 1.215 ± 0.25
1.162HisGln: 1.162 ± 0.288
0.951HisArg: 0.951 ± 0.236
0.74HisSer: 0.74 ± 0.233
0.634HisThr: 0.634 ± 0.167
1.268HisVal: 1.268 ± 0.241
0.475HisTrp: 0.475 ± 0.131
0.634HisTyr: 0.634 ± 0.166
0.0HisXaa: 0.0 ± 0.0
Ile
4.648IleAla: 4.648 ± 0.562
0.845IleCys: 0.845 ± 0.189
3.434IleAsp: 3.434 ± 0.512
3.222IleGlu: 3.222 ± 0.475
1.215IlePhe: 1.215 ± 0.296
4.543IleGly: 4.543 ± 0.51
1.056IleHis: 1.056 ± 0.245
2.641IleIle: 2.641 ± 0.4
2.324IleLys: 2.324 ± 0.408
3.328IleLeu: 3.328 ± 0.465
1.321IleMet: 1.321 ± 0.218
2.641IleAsn: 2.641 ± 0.405
2.536IlePro: 2.536 ± 0.322
1.743IleGln: 1.743 ± 0.24
3.539IleArg: 3.539 ± 0.407
3.592IleSer: 3.592 ± 0.481
3.011IleThr: 3.011 ± 0.422
3.803IleVal: 3.803 ± 0.497
0.528IleTrp: 0.528 ± 0.16
1.638IleTyr: 1.638 ± 0.279
0.0IleXaa: 0.0 ± 0.0
Lys
4.86LysAla: 4.86 ± 0.512
0.158LysCys: 0.158 ± 0.089
2.06LysAsp: 2.06 ± 0.28
2.747LysGlu: 2.747 ± 0.462
1.638LysPhe: 1.638 ± 0.311
2.43LysGly: 2.43 ± 0.366
1.109LysHis: 1.109 ± 0.188
2.166LysIle: 2.166 ± 0.436
1.849LysLys: 1.849 ± 0.288
3.803LysLeu: 3.803 ± 0.499
1.479LysMet: 1.479 ± 0.261
1.743LysAsn: 1.743 ± 0.304
2.588LysPro: 2.588 ± 0.371
2.483LysGln: 2.483 ± 0.427
3.381LysArg: 3.381 ± 0.452
3.434LysSer: 3.434 ± 0.406
2.641LysThr: 2.641 ± 0.383
3.222LysVal: 3.222 ± 0.375
1.215LysTrp: 1.215 ± 0.231
1.743LysTyr: 1.743 ± 0.252
0.0LysXaa: 0.0 ± 0.0
Leu
9.508LeuAla: 9.508 ± 0.877
0.951LeuCys: 0.951 ± 0.252
5.071LeuAsp: 5.071 ± 0.562
4.913LeuGlu: 4.913 ± 0.605
2.8LeuPhe: 2.8 ± 0.443
6.603LeuGly: 6.603 ± 0.633
1.585LeuHis: 1.585 ± 0.234
4.384LeuIle: 4.384 ± 0.44
3.909LeuLys: 3.909 ± 0.498
7.607LeuLeu: 7.607 ± 0.69
2.06LeuMet: 2.06 ± 0.292
4.12LeuAsn: 4.12 ± 0.449
5.23LeuPro: 5.23 ± 0.704
3.434LeuGln: 3.434 ± 0.592
5.494LeuArg: 5.494 ± 0.687
6.339LeuSer: 6.339 ± 0.575
5.018LeuThr: 5.018 ± 0.44
5.335LeuVal: 5.335 ± 0.546
1.215LeuTrp: 1.215 ± 0.27
2.007LeuTyr: 2.007 ± 0.288
0.0LeuXaa: 0.0 ± 0.0
Met
2.905MetAla: 2.905 ± 0.477
0.158MetCys: 0.158 ± 0.086
1.479MetAsp: 1.479 ± 0.271
1.69MetGlu: 1.69 ± 0.399
1.056MetPhe: 1.056 ± 0.262
1.426MetGly: 1.426 ± 0.332
0.528MetHis: 0.528 ± 0.174
1.109MetIle: 1.109 ± 0.261
1.69MetLys: 1.69 ± 0.296
2.694MetLeu: 2.694 ± 0.358
1.109MetMet: 1.109 ± 0.269
1.69MetAsn: 1.69 ± 0.295
1.268MetPro: 1.268 ± 0.219
1.902MetGln: 1.902 ± 0.376
1.849MetArg: 1.849 ± 0.277
1.796MetSer: 1.796 ± 0.289
2.166MetThr: 2.166 ± 0.303
1.426MetVal: 1.426 ± 0.33
0.317MetTrp: 0.317 ± 0.135
0.634MetTyr: 0.634 ± 0.169
0.0MetXaa: 0.0 ± 0.0
Asn
4.173AsnAla: 4.173 ± 0.515
0.581AsnCys: 0.581 ± 0.138
2.8AsnAsp: 2.8 ± 0.416
1.849AsnGlu: 1.849 ± 0.268
1.215AsnPhe: 1.215 ± 0.217
3.909AsnGly: 3.909 ± 0.611
0.634AsnHis: 0.634 ± 0.212
2.007AsnIle: 2.007 ± 0.361
2.219AsnLys: 2.219 ± 0.375
3.486AsnLeu: 3.486 ± 0.393
0.687AsnMet: 0.687 ± 0.164
1.902AsnAsn: 1.902 ± 0.517
2.166AsnPro: 2.166 ± 0.451
2.06AsnGln: 2.06 ± 0.3
2.06AsnArg: 2.06 ± 0.286
2.43AsnSer: 2.43 ± 0.358
2.271AsnThr: 2.271 ± 0.346
2.747AsnVal: 2.747 ± 0.384
0.475AsnTrp: 0.475 ± 0.177
1.162AsnTyr: 1.162 ± 0.216
0.0AsnXaa: 0.0 ± 0.0
Pro
5.441ProAla: 5.441 ± 0.703
0.264ProCys: 0.264 ± 0.112
2.271ProAsp: 2.271 ± 0.374
3.962ProGlu: 3.962 ± 0.506
1.849ProPhe: 1.849 ± 0.281
3.645ProGly: 3.645 ± 0.492
0.845ProHis: 0.845 ± 0.242
1.954ProIle: 1.954 ± 0.335
1.426ProLys: 1.426 ± 0.254
4.437ProLeu: 4.437 ± 0.683
1.162ProMet: 1.162 ± 0.206
1.004ProAsn: 1.004 ± 0.255
1.638ProPro: 1.638 ± 0.339
2.007ProGln: 2.007 ± 0.339
2.166ProArg: 2.166 ± 0.444
2.43ProSer: 2.43 ± 0.422
2.641ProThr: 2.641 ± 0.313
3.698ProVal: 3.698 ± 0.406
1.056ProTrp: 1.056 ± 0.214
0.845ProTyr: 0.845 ± 0.222
0.0ProXaa: 0.0 ± 0.0
Gln
5.018GlnAla: 5.018 ± 0.586
0.423GlnCys: 0.423 ± 0.135
2.377GlnAsp: 2.377 ± 0.439
2.271GlnGlu: 2.271 ± 0.315
1.796GlnPhe: 1.796 ± 0.349
2.694GlnGly: 2.694 ± 0.388
1.162GlnHis: 1.162 ± 0.219
2.166GlnIle: 2.166 ± 0.323
2.06GlnLys: 2.06 ± 0.255
4.86GlnLeu: 4.86 ± 0.594
1.902GlnMet: 1.902 ± 0.312
1.479GlnAsn: 1.479 ± 0.328
1.796GlnPro: 1.796 ± 0.351
4.754GlnGln: 4.754 ± 0.755
3.434GlnArg: 3.434 ± 0.384
2.747GlnSer: 2.747 ± 0.415
2.483GlnThr: 2.483 ± 0.355
3.011GlnVal: 3.011 ± 0.381
0.634GlnTrp: 0.634 ± 0.174
1.743GlnTyr: 1.743 ± 0.361
0.0GlnXaa: 0.0 ± 0.0
Arg
5.177ArgAla: 5.177 ± 0.544
1.004ArgCys: 1.004 ± 0.302
3.592ArgAsp: 3.592 ± 0.435
4.384ArgGlu: 4.384 ± 0.496
2.113ArgPhe: 2.113 ± 0.363
3.539ArgGly: 3.539 ± 0.371
1.426ArgHis: 1.426 ± 0.275
4.648ArgIle: 4.648 ± 0.588
3.169ArgLys: 3.169 ± 0.392
6.233ArgLeu: 6.233 ± 0.859
2.06ArgMet: 2.06 ± 0.275
2.271ArgAsn: 2.271 ± 0.345
2.06ArgPro: 2.06 ± 0.284
3.803ArgGln: 3.803 ± 0.499
4.543ArgArg: 4.543 ± 0.61
3.011ArgSer: 3.011 ± 0.318
2.905ArgThr: 2.905 ± 0.344
4.596ArgVal: 4.596 ± 0.486
1.321ArgTrp: 1.321 ± 0.341
2.219ArgTyr: 2.219 ± 0.33
0.0ArgXaa: 0.0 ± 0.0
Ser
6.022SerAla: 6.022 ± 0.582
0.475SerCys: 0.475 ± 0.183
4.226SerAsp: 4.226 ± 0.494
3.222SerGlu: 3.222 ± 0.392
1.954SerPhe: 1.954 ± 0.279
5.335SerGly: 5.335 ± 0.624
1.268SerHis: 1.268 ± 0.29
3.011SerIle: 3.011 ± 0.402
2.641SerLys: 2.641 ± 0.43
4.965SerLeu: 4.965 ± 0.431
1.426SerMet: 1.426 ± 0.241
2.536SerAsn: 2.536 ± 0.379
3.434SerPro: 3.434 ± 0.469
2.588SerGln: 2.588 ± 0.355
4.173SerArg: 4.173 ± 0.475
3.434SerSer: 3.434 ± 0.555
3.75SerThr: 3.75 ± 0.419
3.856SerVal: 3.856 ± 0.476
0.898SerTrp: 0.898 ± 0.208
1.426SerTyr: 1.426 ± 0.213
0.0SerXaa: 0.0 ± 0.0
Thr
5.705ThrAla: 5.705 ± 0.405
0.37ThrCys: 0.37 ± 0.141
3.856ThrAsp: 3.856 ± 0.444
2.483ThrGlu: 2.483 ± 0.335
1.796ThrPhe: 1.796 ± 0.256
4.754ThrGly: 4.754 ± 0.571
0.898ThrHis: 0.898 ± 0.208
2.905ThrIle: 2.905 ± 0.425
2.113ThrLys: 2.113 ± 0.329
5.863ThrLeu: 5.863 ± 0.65
1.162ThrMet: 1.162 ± 0.235
1.902ThrAsn: 1.902 ± 0.324
3.169ThrPro: 3.169 ± 0.341
2.007ThrGln: 2.007 ± 0.26
2.8ThrArg: 2.8 ± 0.543
3.222ThrSer: 3.222 ± 0.528
3.381ThrThr: 3.381 ± 0.384
4.279ThrVal: 4.279 ± 0.61
0.792ThrTrp: 0.792 ± 0.222
0.951ThrTyr: 0.951 ± 0.325
0.0ThrXaa: 0.0 ± 0.0
Val
6.128ValAla: 6.128 ± 0.627
0.687ValCys: 0.687 ± 0.195
3.486ValAsp: 3.486 ± 0.37
4.701ValGlu: 4.701 ± 0.528
1.954ValPhe: 1.954 ± 0.367
4.12ValGly: 4.12 ± 0.446
0.792ValHis: 0.792 ± 0.162
3.486ValIle: 3.486 ± 0.38
3.592ValLys: 3.592 ± 0.494
5.124ValLeu: 5.124 ± 0.532
2.536ValMet: 2.536 ± 0.351
2.958ValAsn: 2.958 ± 0.421
3.011ValPro: 3.011 ± 0.52
2.324ValGln: 2.324 ± 0.272
3.698ValArg: 3.698 ± 0.423
5.282ValSer: 5.282 ± 0.438
5.335ValThr: 5.335 ± 0.709
5.441ValVal: 5.441 ± 0.543
1.162ValTrp: 1.162 ± 0.323
1.69ValTyr: 1.69 ± 0.289
0.0ValXaa: 0.0 ± 0.0
Trp
1.268TrpAla: 1.268 ± 0.239
0.158TrpCys: 0.158 ± 0.109
0.634TrpAsp: 0.634 ± 0.172
0.898TrpGlu: 0.898 ± 0.229
0.634TrpPhe: 0.634 ± 0.203
0.845TrpGly: 0.845 ± 0.226
0.475TrpHis: 0.475 ± 0.138
0.687TrpIle: 0.687 ± 0.172
0.792TrpLys: 0.792 ± 0.18
1.954TrpLeu: 1.954 ± 0.346
0.581TrpMet: 0.581 ± 0.159
0.634TrpAsn: 0.634 ± 0.17
0.74TrpPro: 0.74 ± 0.28
0.792TrpGln: 0.792 ± 0.236
1.69TrpArg: 1.69 ± 0.372
1.056TrpSer: 1.056 ± 0.224
0.634TrpThr: 0.634 ± 0.188
1.004TrpVal: 1.004 ± 0.245
0.37TrpTrp: 0.37 ± 0.146
0.475TrpTyr: 0.475 ± 0.143
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.8TyrAla: 2.8 ± 0.543
0.634TyrCys: 0.634 ± 0.17
1.69TyrAsp: 1.69 ± 0.343
1.268TyrGlu: 1.268 ± 0.24
0.951TyrPhe: 0.951 ± 0.262
2.747TyrGly: 2.747 ± 0.313
0.581TyrHis: 0.581 ± 0.173
1.215TyrIle: 1.215 ± 0.397
1.321TyrLys: 1.321 ± 0.278
2.324TyrLeu: 2.324 ± 0.431
0.687TyrMet: 0.687 ± 0.198
1.162TyrAsn: 1.162 ± 0.29
1.162TyrPro: 1.162 ± 0.241
1.743TyrGln: 1.743 ± 0.352
2.271TyrArg: 2.271 ± 0.262
2.06TyrSer: 2.06 ± 0.331
1.585TyrThr: 1.585 ± 0.313
1.69TyrVal: 1.69 ± 0.273
0.423TyrTrp: 0.423 ± 0.156
0.634TyrTyr: 0.634 ± 0.233
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 75 proteins (18932 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski