Amino acid dipepetide frequency for Halapricum sp. CBA1109

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	14.026AlaAla: 14.026 ± 0.22	0.642AlaCys: 0.642 ± 0.033	10.048AlaAsp: 10.048 ± 0.156	8.369AlaGlu: 8.369 ± 0.148	3.721AlaPhe: 3.721 ± 0.078	9.684AlaGly: 9.684 ± 0.146	1.683AlaHis: 1.683 ± 0.051	4.485AlaIle: 4.485 ± 0.074	1.539AlaLys: 1.539 ± 0.05	9.865AlaLeu: 9.865 ± 0.149	2.035AlaMet: 2.035 ± 0.055	2.218AlaAsn: 2.218 ± 0.056	3.813AlaPro: 3.813 ± 0.08	2.162AlaGln: 2.162 ± 0.068	6.029AlaArg: 6.029 ± 0.117	5.679AlaSer: 5.679 ± 0.096	7.392AlaThr: 7.392 ± 0.117	11.597AlaVal: 11.597 ± 0.169	1.042AlaTrp: 1.042 ± 0.042	2.715AlaTyr: 2.715 ± 0.062	0.0AlaXaa: 0.0 ± 0.0
Cys	0.562CysAla: 0.562 ± 0.029	0.069CysCys: 0.069 ± 0.01	0.524CysAsp: 0.524 ± 0.03	0.471CysGlu: 0.471 ± 0.03	0.205CysPhe: 0.205 ± 0.019	0.83CysGly: 0.83 ± 0.041	0.188CysHis: 0.188 ± 0.019	0.256CysIle: 0.256 ± 0.017	0.113CysLys: 0.113 ± 0.012	0.496CysLeu: 0.496 ± 0.027	0.104CysMet: 0.104 ± 0.012	0.168CysAsn: 0.168 ± 0.018	0.543CysPro: 0.543 ± 0.033	0.177CysGln: 0.177 ± 0.016	0.539CysArg: 0.539 ± 0.029	0.503CysSer: 0.503 ± 0.027	0.394CysThr: 0.394 ± 0.023	0.482CysVal: 0.482 ± 0.027	0.076CysTrp: 0.076 ± 0.011	0.181CysTyr: 0.181 ± 0.018	0.0CysXaa: 0.0 ± 0.0
Asp	10.279AspAla: 10.279 ± 0.143	0.665AspCys: 0.665 ± 0.038	8.075AspAsp: 8.075 ± 0.144	6.673AspGlu: 6.673 ± 0.121	1.986AspPhe: 1.986 ± 0.056	9.328AspGly: 9.328 ± 0.195	2.093AspHis: 2.093 ± 0.065	3.808AspIle: 3.808 ± 0.078	0.907AspLys: 0.907 ± 0.041	6.563AspLeu: 6.563 ± 0.118	1.226AspMet: 1.226 ± 0.042	1.534AspAsn: 1.534 ± 0.045	5.232AspPro: 5.232 ± 0.093	1.777AspGln: 1.777 ± 0.053	7.311AspArg: 7.311 ± 0.117	4.395AspSer: 4.395 ± 0.095	5.027AspThr: 5.027 ± 0.095	7.268AspVal: 7.268 ± 0.112	0.95AspTrp: 0.95 ± 0.037	1.946AspTyr: 1.946 ± 0.056	0.0AspXaa: 0.0 ± 0.0
Glu	8.293GluAla: 8.293 ± 0.128	0.504GluCys: 0.504 ± 0.03	6.415GluAsp: 6.415 ± 0.109	6.093GluGlu: 6.093 ± 0.126	2.557GluPhe: 2.557 ± 0.063	5.538GluGly: 5.538 ± 0.098	1.582GluHis: 1.582 ± 0.052	3.313GluIle: 3.313 ± 0.078	1.637GluLys: 1.637 ± 0.053	6.434GluLeu: 6.434 ± 0.115	1.982GluMet: 1.982 ± 0.054	2.19GluAsn: 2.19 ± 0.065	3.161GluPro: 3.161 ± 0.08	2.946GluGln: 2.946 ± 0.069	6.826GluArg: 6.826 ± 0.122	5.315GluSer: 5.315 ± 0.089	6.555GluThr: 6.555 ± 0.098	5.108GluVal: 5.108 ± 0.09	1.157GluTrp: 1.157 ± 0.04	2.711GluTyr: 2.711 ± 0.067	0.0GluXaa: 0.0 ± 0.0
Phe	3.356PheAla: 3.356 ± 0.073	0.265PheCys: 0.265 ± 0.018	3.467PheAsp: 3.467 ± 0.077	3.299PheGlu: 3.299 ± 0.071	0.98PhePhe: 0.98 ± 0.04	3.227PheGly: 3.227 ± 0.07	0.59PheHis: 0.59 ± 0.029	0.826PheIle: 0.826 ± 0.041	0.408PheLys: 0.408 ± 0.025	2.733PheLeu: 2.733 ± 0.074	0.491PheMet: 0.491 ± 0.03	0.65PheAsn: 0.65 ± 0.031	1.299PhePro: 1.299 ± 0.042	0.71PheGln: 0.71 ± 0.037	1.789PheArg: 1.789 ± 0.049	1.745PheSer: 1.745 ± 0.046	1.832PheThr: 1.832 ± 0.047	3.299PheVal: 3.299 ± 0.068	0.388PheTrp: 0.388 ± 0.026	0.807PheTyr: 0.807 ± 0.036	0.0PheXaa: 0.0 ± 0.0
Gly	7.853GlyAla: 7.853 ± 0.125	0.666GlyCys: 0.666 ± 0.031	7.554GlyAsp: 7.554 ± 0.15	7.11GlyGlu: 7.11 ± 0.12	3.0GlyPhe: 3.0 ± 0.078	7.797GlyGly: 7.797 ± 0.154	1.678GlyHis: 1.678 ± 0.052	4.135GlyIle: 4.135 ± 0.083	1.586GlyLys: 1.586 ± 0.043	7.153GlyLeu: 7.153 ± 0.128	1.666GlyMet: 1.666 ± 0.054	1.929GlyAsn: 1.929 ± 0.057	3.881GlyPro: 3.881 ± 0.093	2.179GlyGln: 2.179 ± 0.056	5.167GlyArg: 5.167 ± 0.1	5.399GlySer: 5.399 ± 0.115	6.47GlyThr: 6.47 ± 0.109	8.027GlyVal: 8.027 ± 0.117	1.035GlyTrp: 1.035 ± 0.039	2.676GlyTyr: 2.676 ± 0.058	0.0GlyXaa: 0.0 ± 0.0
His	1.848HisAla: 1.848 ± 0.049	0.198HisCys: 0.198 ± 0.018	1.727HisAsp: 1.727 ± 0.051	1.495HisGlu: 1.495 ± 0.043	0.558HisPhe: 0.558 ± 0.025	1.814HisGly: 1.814 ± 0.053	0.511HisHis: 0.511 ± 0.025	0.647HisIle: 0.647 ± 0.032	0.29HisLys: 0.29 ± 0.023	1.539HisLeu: 1.539 ± 0.047	0.26HisMet: 0.26 ± 0.021	0.458HisAsn: 0.458 ± 0.03	1.175HisPro: 1.175 ± 0.042	0.452HisGln: 0.452 ± 0.027	1.363HisArg: 1.363 ± 0.05	0.91HisSer: 0.91 ± 0.035	1.061HisThr: 1.061 ± 0.042	1.73HisVal: 1.73 ± 0.059	0.238HisTrp: 0.238 ± 0.019	0.55HisTyr: 0.55 ± 0.026	0.0HisXaa: 0.0 ± 0.0
Ile	4.417IleAla: 4.417 ± 0.093	0.229IleCys: 0.229 ± 0.016	3.966IleAsp: 3.966 ± 0.08	4.121IleGlu: 4.121 ± 0.094	0.919IlePhe: 0.919 ± 0.038	3.481IleGly: 3.481 ± 0.074	0.719IleHis: 0.719 ± 0.028	1.139IleIle: 1.139 ± 0.043	0.688IleLys: 0.688 ± 0.032	2.816IleLeu: 2.816 ± 0.075	0.44IleMet: 0.44 ± 0.023	0.954IleAsn: 0.954 ± 0.041	2.043IlePro: 2.043 ± 0.058	1.038IleGln: 1.038 ± 0.044	2.405IleArg: 2.405 ± 0.06	2.068IleSer: 2.068 ± 0.058	2.446IleThr: 2.446 ± 0.063	3.691IleVal: 3.691 ± 0.085	0.279IleTrp: 0.279 ± 0.019	0.849IleTyr: 0.849 ± 0.038	0.0IleXaa: 0.0 ± 0.0
Lys	1.512LysAla: 1.512 ± 0.052	0.132LysCys: 0.132 ± 0.014	0.967LysAsp: 0.967 ± 0.04	1.152LysGlu: 1.152 ± 0.048	0.449LysPhe: 0.449 ± 0.025	1.16LysGly: 1.16 ± 0.045	0.41LysHis: 0.41 ± 0.022	0.721LysIle: 0.721 ± 0.036	0.448LysLys: 0.448 ± 0.03	1.462LysLeu: 1.462 ± 0.044	0.381LysMet: 0.381 ± 0.023	0.478LysAsn: 0.478 ± 0.028	0.794LysPro: 0.794 ± 0.032	0.687LysGln: 0.687 ± 0.037	1.573LysArg: 1.573 ± 0.053	1.057LysSer: 1.057 ± 0.044	1.138LysThr: 1.138 ± 0.041	1.084LysVal: 1.084 ± 0.039	0.213LysTrp: 0.213 ± 0.018	0.53LysTyr: 0.53 ± 0.026	0.0LysXaa: 0.0 ± 0.0
Leu	10.517LeuAla: 10.517 ± 0.159	0.499LeuCys: 0.499 ± 0.03	7.679LeuAsp: 7.679 ± 0.11	5.89LeuGlu: 5.89 ± 0.103	3.188LeuPhe: 3.188 ± 0.079	7.441LeuGly: 7.441 ± 0.142	1.277LeuHis: 1.277 ± 0.045	2.67LeuIle: 2.67 ± 0.069	1.367LeuLys: 1.367 ± 0.045	8.71LeuLeu: 8.71 ± 0.167	1.143LeuMet: 1.143 ± 0.042	1.714LeuAsn: 1.714 ± 0.053	4.054LeuPro: 4.054 ± 0.084	2.094LeuGln: 2.094 ± 0.057	5.278LeuArg: 5.278 ± 0.094	6.242LeuSer: 6.242 ± 0.111	5.586LeuThr: 5.586 ± 0.098	8.013LeuVal: 8.013 ± 0.126	0.882LeuTrp: 0.882 ± 0.036	2.291LeuTyr: 2.291 ± 0.057	0.0LeuXaa: 0.0 ± 0.0
Met	2.016MetAla: 2.016 ± 0.055	0.085MetCys: 0.085 ± 0.011	1.436MetAsp: 1.436 ± 0.056	1.033MetGlu: 1.033 ± 0.038	0.46MetPhe: 0.46 ± 0.025	1.406MetGly: 1.406 ± 0.047	0.349MetHis: 0.349 ± 0.019	0.65MetIle: 0.65 ± 0.032	0.352MetLys: 0.352 ± 0.022	1.392MetLeu: 1.392 ± 0.046	0.275MetMet: 0.275 ± 0.021	0.529MetAsn: 0.529 ± 0.027	0.82MetPro: 0.82 ± 0.033	0.474MetGln: 0.474 ± 0.025	1.003MetArg: 1.003 ± 0.033	1.492MetSer: 1.492 ± 0.044	1.461MetThr: 1.461 ± 0.045	1.369MetVal: 1.369 ± 0.05	0.147MetTrp: 0.147 ± 0.014	0.37MetTyr: 0.37 ± 0.025	0.0MetXaa: 0.0 ± 0.0
Asn	2.284AsnAla: 2.284 ± 0.06	0.208AsnCys: 0.208 ± 0.019	1.663AsnAsp: 1.663 ± 0.056	1.556AsnGlu: 1.556 ± 0.056	0.647AsnPhe: 0.647 ± 0.032	2.133AsnGly: 2.133 ± 0.078	0.492AsnHis: 0.492 ± 0.029	0.822AsnIle: 0.822 ± 0.036	0.444AsnLys: 0.444 ± 0.027	1.828AsnLeu: 1.828 ± 0.059	0.405AsnMet: 0.405 ± 0.023	0.682AsnAsn: 0.682 ± 0.037	1.398AsnPro: 1.398 ± 0.045	0.624AsnGln: 0.624 ± 0.033	1.589AsnArg: 1.589 ± 0.052	1.044AsnSer: 1.044 ± 0.044	1.392AsnThr: 1.392 ± 0.048	2.273AsnVal: 2.273 ± 0.049	0.28AsnTrp: 0.28 ± 0.019	0.665AsnTyr: 0.665 ± 0.03	0.0AsnXaa: 0.0 ± 0.0
Pro	4.845ProAla: 4.845 ± 0.086	0.246ProCys: 0.246 ± 0.022	4.826ProAsp: 4.826 ± 0.097	4.669ProGlu: 4.669 ± 0.093	1.602ProPhe: 1.602 ± 0.053	3.883ProGly: 3.883 ± 0.086	0.822ProHis: 0.822 ± 0.036	1.811ProIle: 1.811 ± 0.05	0.827ProLys: 0.827 ± 0.038	3.742ProLeu: 3.742 ± 0.087	0.823ProMet: 0.823 ± 0.03	1.15ProAsn: 1.15 ± 0.049	2.483ProPro: 2.483 ± 0.065	0.998ProGln: 0.998 ± 0.037	2.527ProArg: 2.527 ± 0.061	2.97ProSer: 2.97 ± 0.068	3.5ProThr: 3.5 ± 0.078	4.265ProVal: 4.265 ± 0.08	0.508ProTrp: 0.508 ± 0.026	1.209ProTyr: 1.209 ± 0.04	0.0ProXaa: 0.0 ± 0.0
Gln	2.497GlnAla: 2.497 ± 0.068	0.181GlnCys: 0.181 ± 0.016	1.332GlnAsp: 1.332 ± 0.047	1.534GlnGlu: 1.534 ± 0.053	1.146GlnPhe: 1.146 ± 0.036	1.609GlnGly: 1.609 ± 0.047	0.51GlnHis: 0.51 ± 0.029	1.102GlnIle: 1.102 ± 0.045	0.53GlnLys: 0.53 ± 0.028	2.288GlnLeu: 2.288 ± 0.052	0.489GlnMet: 0.489 ± 0.024	0.669GlnAsn: 0.669 ± 0.033	1.163GlnPro: 1.163 ± 0.042	1.076GlnGln: 1.076 ± 0.04	2.35GlnArg: 2.35 ± 0.061	1.83GlnSer: 1.83 ± 0.056	1.749GlnThr: 1.749 ± 0.048	1.881GlnVal: 1.881 ± 0.049	0.408GlnTrp: 0.408 ± 0.028	0.937GlnTyr: 0.937 ± 0.034	0.0GlnXaa: 0.0 ± 0.0
Arg	6.434ArgAla: 6.434 ± 0.124	0.529ArgCys: 0.529 ± 0.032	4.635ArgAsp: 4.635 ± 0.081	6.483ArgGlu: 6.483 ± 0.117	2.336ArgPhe: 2.336 ± 0.06	4.276ArgGly: 4.276 ± 0.077	1.314ArgHis: 1.314 ± 0.047	2.974ArgIle: 2.974 ± 0.066	1.282ArgLys: 1.282 ± 0.047	6.162ArgLeu: 6.162 ± 0.092	1.374ArgMet: 1.374 ± 0.037	1.569ArgAsn: 1.569 ± 0.051	3.055ArgPro: 3.055 ± 0.08	2.123ArgGln: 2.123 ± 0.063	5.776ArgArg: 5.776 ± 0.111	3.94ArgSer: 3.94 ± 0.074	4.439ArgThr: 4.439 ± 0.101	5.177ArgVal: 5.177 ± 0.09	0.888ArgTrp: 0.888 ± 0.037	2.096ArgTyr: 2.096 ± 0.054	0.0ArgXaa: 0.0 ± 0.0
Ser	5.92SerAla: 5.92 ± 0.092	0.381SerCys: 0.381 ± 0.024	4.591SerAsp: 4.591 ± 0.101	4.223SerGlu: 4.223 ± 0.071	1.895SerPhe: 1.895 ± 0.054	5.88SerGly: 5.88 ± 0.113	1.038SerHis: 1.038 ± 0.039	2.424SerIle: 2.424 ± 0.06	1.103SerLys: 1.103 ± 0.042	5.133SerLeu: 5.133 ± 0.093	1.176SerMet: 1.176 ± 0.046	1.266SerAsn: 1.266 ± 0.05	2.872SerPro: 2.872 ± 0.075	1.373SerGln: 1.373 ± 0.049	3.441SerArg: 3.441 ± 0.074	3.082SerSer: 3.082 ± 0.078	3.923SerThr: 3.923 ± 0.084	5.947SerVal: 5.947 ± 0.111	0.665SerTrp: 0.665 ± 0.034	1.562SerTyr: 1.562 ± 0.05	0.0SerXaa: 0.0 ± 0.0
Thr	7.763ThrAla: 7.763 ± 0.11	0.374ThrCys: 0.374 ± 0.025	6.368ThrAsp: 6.368 ± 0.105	4.775ThrGlu: 4.775 ± 0.082	2.222ThrPhe: 2.222 ± 0.057	6.111ThrGly: 6.111 ± 0.11	1.185ThrHis: 1.185 ± 0.047	2.867ThrIle: 2.867 ± 0.067	0.961ThrLys: 0.961 ± 0.04	6.21ThrLeu: 6.21 ± 0.095	1.027ThrMet: 1.027 ± 0.042	1.516ThrAsn: 1.516 ± 0.059	3.533ThrPro: 3.533 ± 0.075	1.407ThrGln: 1.407 ± 0.042	3.523ThrArg: 3.523 ± 0.073	3.053ThrSer: 3.053 ± 0.074	5.027ThrThr: 5.027 ± 0.113	8.365ThrVal: 8.365 ± 0.156	0.572ThrTrp: 0.572 ± 0.027	1.922ThrTyr: 1.922 ± 0.061	0.0ThrXaa: 0.0 ± 0.0
Val	10.717ValAla: 10.717 ± 0.167	0.677ValCys: 0.677 ± 0.032	8.104ValAsp: 8.104 ± 0.107	8.181ValGlu: 8.181 ± 0.119	3.036ValPhe: 3.036 ± 0.073	8.242ValGly: 8.242 ± 0.137	1.56ValHis: 1.56 ± 0.043	2.86ValIle: 2.86 ± 0.067	1.219ValLys: 1.219 ± 0.039	8.361ValLeu: 8.361 ± 0.143	1.251ValMet: 1.251 ± 0.05	1.696ValAsn: 1.696 ± 0.055	4.671ValPro: 4.671 ± 0.084	1.865ValGln: 1.865 ± 0.052	5.358ValArg: 5.358 ± 0.096	5.211ValSer: 5.211 ± 0.084	6.824ValThr: 6.824 ± 0.132	9.776ValVal: 9.776 ± 0.156	0.859ValTrp: 0.859 ± 0.037	2.292ValTyr: 2.292 ± 0.06	0.0ValXaa: 0.0 ± 0.0
Trp	0.955TrpAla: 0.955 ± 0.041	0.098TrpCys: 0.098 ± 0.012	0.778TrpAsp: 0.778 ± 0.035	0.838TrpGlu: 0.838 ± 0.034	0.399TrpPhe: 0.399 ± 0.023	0.721TrpGly: 0.721 ± 0.033	0.202TrpHis: 0.202 ± 0.019	0.436TrpIle: 0.436 ± 0.024	0.234TrpLys: 0.234 ± 0.018	1.202TrpLeu: 1.202 ± 0.048	0.199TrpMet: 0.199 ± 0.017	0.335TrpAsn: 0.335 ± 0.022	0.445TrpPro: 0.445 ± 0.027	0.385TrpGln: 0.385 ± 0.024	0.849TrpArg: 0.849 ± 0.037	0.672TrpSer: 0.672 ± 0.032	0.889TrpThr: 0.889 ± 0.038	0.939TrpVal: 0.939 ± 0.033	0.19TrpTrp: 0.19 ± 0.016	0.345TrpTyr: 0.345 ± 0.023	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.651TyrAla: 2.651 ± 0.062	0.232TyrCys: 0.232 ± 0.016	2.886TyrAsp: 2.886 ± 0.079	2.351TyrGlu: 2.351 ± 0.063	0.853TyrPhe: 0.853 ± 0.031	2.398TyrGly: 2.398 ± 0.067	0.624TyrHis: 0.624 ± 0.033	0.763TyrIle: 0.763 ± 0.034	0.414TyrLys: 0.414 ± 0.025	2.446TyrLeu: 2.446 ± 0.061	0.372TyrMet: 0.372 ± 0.023	0.723TyrAsn: 0.723 ± 0.037	1.275TyrPro: 1.275 ± 0.04	0.735TyrGln: 0.735 ± 0.034	2.166TyrArg: 2.166 ± 0.056	1.288TyrSer: 1.288 ± 0.045	1.677TyrThr: 1.677 ± 0.049	2.467TyrVal: 2.467 ± 0.055	0.335TyrTrp: 0.335 ± 0.024	0.89TyrTyr: 0.89 ± 0.041	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2712 proteins (727707 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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