Amino acid dipepetide frequency for Eubacterium infirmum F0142

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
5.497AlaAla: 5.497 ± 0.119
1.05AlaCys: 1.05 ± 0.047
4.346AlaAsp: 4.346 ± 0.097
5.38AlaGlu: 5.38 ± 0.115
2.884AlaPhe: 2.884 ± 0.09
4.985AlaGly: 4.985 ± 0.117
1.052AlaHis: 1.052 ± 0.046
6.061AlaIle: 6.061 ± 0.119
5.57AlaLys: 5.57 ± 0.114
6.803AlaLeu: 6.803 ± 0.132
2.143AlaMet: 2.143 ± 0.072
2.84AlaAsn: 2.84 ± 0.075
1.885AlaPro: 1.885 ± 0.062
1.733AlaGln: 1.733 ± 0.059
2.842AlaArg: 2.842 ± 0.073
4.306AlaSer: 4.306 ± 0.091
3.266AlaThr: 3.266 ± 0.084
5.296AlaVal: 5.296 ± 0.107
0.44AlaTrp: 0.44 ± 0.03
2.543AlaTyr: 2.543 ± 0.061
0.0AlaXaa: 0.0 ± 0.0
Cys
0.828CysAla: 0.828 ± 0.038
0.218CysCys: 0.218 ± 0.021
0.898CysAsp: 0.898 ± 0.043
0.962CysGlu: 0.962 ± 0.045
0.597CysPhe: 0.597 ± 0.037
1.415CysGly: 1.415 ± 0.07
0.241CysHis: 0.241 ± 0.023
1.139CysIle: 1.139 ± 0.046
1.032CysLys: 1.032 ± 0.047
0.915CysLeu: 0.915 ± 0.041
0.355CysMet: 0.355 ± 0.024
0.622CysAsn: 0.622 ± 0.035
0.51CysPro: 0.51 ± 0.04
0.253CysGln: 0.253 ± 0.021
0.578CysArg: 0.578 ± 0.034
0.763CysSer: 0.763 ± 0.041
0.569CysThr: 0.569 ± 0.032
0.793CysVal: 0.793 ± 0.039
0.072CysTrp: 0.072 ± 0.011
0.424CysTyr: 0.424 ± 0.026
0.0CysXaa: 0.0 ± 0.0
Asp
4.084AspAla: 4.084 ± 0.106
0.73AspCys: 0.73 ± 0.038
3.431AspAsp: 3.431 ± 0.084
5.638AspGlu: 5.638 ± 0.102
2.973AspPhe: 2.973 ± 0.065
4.658AspGly: 4.658 ± 0.102
0.709AspHis: 0.709 ± 0.036
5.575AspIle: 5.575 ± 0.116
5.305AspLys: 5.305 ± 0.114
4.372AspLeu: 4.372 ± 0.084
1.834AspMet: 1.834 ± 0.064
2.728AspAsn: 2.728 ± 0.077
1.511AspPro: 1.511 ± 0.06
0.919AspGln: 0.919 ± 0.042
2.618AspArg: 2.618 ± 0.07
3.586AspSer: 3.586 ± 0.082
2.713AspThr: 2.713 ± 0.069
4.25AspVal: 4.25 ± 0.109
0.473AspTrp: 0.473 ± 0.029
2.428AspTyr: 2.428 ± 0.061
0.0AspXaa: 0.0 ± 0.0
Glu
5.093GluAla: 5.093 ± 0.114
0.814GluCys: 0.814 ± 0.042
4.129GluAsp: 4.129 ± 0.102
6.119GluGlu: 6.119 ± 0.135
3.132GluPhe: 3.132 ± 0.084
3.988GluGly: 3.988 ± 0.101
1.352GluHis: 1.352 ± 0.053
6.667GluIle: 6.667 ± 0.119
6.721GluLys: 6.721 ± 0.138
7.469GluLeu: 7.469 ± 0.142
2.113GluMet: 2.113 ± 0.06
4.32GluAsn: 4.32 ± 0.093
1.846GluPro: 1.846 ± 0.063
2.047GluGln: 2.047 ± 0.065
3.205GluArg: 3.205 ± 0.08
3.941GluSer: 3.941 ± 0.088
3.261GluThr: 3.261 ± 0.075
4.208GluVal: 4.208 ± 0.088
0.529GluTrp: 0.529 ± 0.033
3.095GluTyr: 3.095 ± 0.091
0.002GluXaa: 0.002 ± 0.002
Phe
3.158PheAla: 3.158 ± 0.074
0.603PheCys: 0.603 ± 0.035
3.563PheAsp: 3.563 ± 0.066
2.943PheGlu: 2.943 ± 0.074
1.911PhePhe: 1.911 ± 0.068
3.032PheGly: 3.032 ± 0.086
0.592PheHis: 0.592 ± 0.033
3.509PheIle: 3.509 ± 0.095
2.83PheLys: 2.83 ± 0.085
3.457PheLeu: 3.457 ± 0.089
1.205PheMet: 1.205 ± 0.051
1.962PheAsn: 1.962 ± 0.063
1.294PhePro: 1.294 ± 0.042
0.84PheGln: 0.84 ± 0.041
1.56PheArg: 1.56 ± 0.059
3.006PheSer: 3.006 ± 0.075
2.426PheThr: 2.426 ± 0.065
2.936PheVal: 2.936 ± 0.08
0.391PheTrp: 0.391 ± 0.027
1.563PheTyr: 1.563 ± 0.05
0.0PheXaa: 0.0 ± 0.0
Gly
4.608GlyAla: 4.608 ± 0.117
0.948GlyCys: 0.948 ± 0.051
3.837GlyAsp: 3.837 ± 0.077
4.803GlyGlu: 4.803 ± 0.096
3.275GlyPhe: 3.275 ± 0.082
4.975GlyGly: 4.975 ± 0.122
1.24GlyHis: 1.24 ± 0.053
6.29GlyIle: 6.29 ± 0.124
6.396GlyLys: 6.396 ± 0.118
5.752GlyLeu: 5.752 ± 0.106
2.051GlyMet: 2.051 ± 0.06
3.231GlyAsn: 3.231 ± 0.085
1.224GlyPro: 1.224 ± 0.057
1.624GlyGln: 1.624 ± 0.058
3.06GlyArg: 3.06 ± 0.076
4.152GlySer: 4.152 ± 0.091
3.771GlyThr: 3.771 ± 0.087
4.679GlyVal: 4.679 ± 0.104
0.526GlyTrp: 0.526 ± 0.038
2.98GlyTyr: 2.98 ± 0.075
0.0GlyXaa: 0.0 ± 0.0
His
0.983HisAla: 0.983 ± 0.041
0.259HisCys: 0.259 ± 0.029
0.886HisAsp: 0.886 ± 0.043
1.022HisGlu: 1.022 ± 0.047
0.774HisPhe: 0.774 ± 0.038
1.174HisGly: 1.174 ± 0.047
0.295HisHis: 0.295 ± 0.034
1.294HisIle: 1.294 ± 0.048
1.083HisLys: 1.083 ± 0.047
1.254HisLeu: 1.254 ± 0.044
0.444HisMet: 0.444 ± 0.028
0.714HisAsn: 0.714 ± 0.041
0.692HisPro: 0.692 ± 0.032
0.407HisGln: 0.407 ± 0.026
0.786HisArg: 0.786 ± 0.036
0.945HisSer: 0.945 ± 0.04
0.852HisThr: 0.852 ± 0.038
0.94HisVal: 0.94 ± 0.041
0.112HisTrp: 0.112 ± 0.017
0.601HisTyr: 0.601 ± 0.031
0.0HisXaa: 0.0 ± 0.0
Ile
6.737IleAla: 6.737 ± 0.114
1.343IleCys: 1.343 ± 0.048
5.513IleAsp: 5.513 ± 0.1
6.189IleGlu: 6.189 ± 0.122
3.593IlePhe: 3.593 ± 0.1
5.696IleGly: 5.696 ± 0.134
1.132IleHis: 1.132 ± 0.053
6.475IleIle: 6.475 ± 0.137
6.683IleLys: 6.683 ± 0.109
7.113IleLeu: 7.113 ± 0.14
2.244IleMet: 2.244 ± 0.067
3.837IleAsn: 3.837 ± 0.09
3.015IlePro: 3.015 ± 0.074
1.614IleGln: 1.614 ± 0.052
3.411IleArg: 3.411 ± 0.081
6.288IleSer: 6.288 ± 0.124
4.159IleThr: 4.159 ± 0.101
5.591IleVal: 5.591 ± 0.11
0.568IleTrp: 0.568 ± 0.031
3.12IleTyr: 3.12 ± 0.084
0.0IleXaa: 0.0 ± 0.0
Lys
5.888LysAla: 5.888 ± 0.132
0.762LysCys: 0.762 ± 0.033
5.17LysAsp: 5.17 ± 0.12
6.491LysGlu: 6.491 ± 0.129
2.604LysPhe: 2.604 ± 0.064
4.835LysGly: 4.835 ± 0.107
1.397LysHis: 1.397 ± 0.049
6.307LysIle: 6.307 ± 0.113
6.819LysLys: 6.819 ± 0.135
7.729LysLeu: 7.729 ± 0.117
2.344LysMet: 2.344 ± 0.07
4.501LysAsn: 4.501 ± 0.115
2.316LysPro: 2.316 ± 0.071
2.384LysGln: 2.384 ± 0.067
3.548LysArg: 3.548 ± 0.089
5.132LysSer: 5.132 ± 0.104
4.321LysThr: 4.321 ± 0.102
4.865LysVal: 4.865 ± 0.09
0.596LysTrp: 0.596 ± 0.036
3.579LysTyr: 3.579 ± 0.088
0.002LysXaa: 0.002 ± 0.002
Leu
6.505LeuAla: 6.505 ± 0.119
1.301LeuCys: 1.301 ± 0.058
5.207LeuAsp: 5.207 ± 0.103
5.951LeuGlu: 5.951 ± 0.113
3.499LeuPhe: 3.499 ± 0.093
5.981LeuGly: 5.981 ± 0.115
1.258LeuHis: 1.258 ± 0.042
7.422LeuIle: 7.422 ± 0.127
6.976LeuLys: 6.976 ± 0.144
7.668LeuLeu: 7.668 ± 0.116
2.713LeuMet: 2.713 ± 0.079
4.243LeuAsn: 4.243 ± 0.086
3.235LeuPro: 3.235 ± 0.086
1.923LeuGln: 1.923 ± 0.059
3.824LeuArg: 3.824 ± 0.085
6.838LeuSer: 6.838 ± 0.11
4.372LeuThr: 4.372 ± 0.099
5.556LeuVal: 5.556 ± 0.121
0.62LeuTrp: 0.62 ± 0.034
2.844LeuTyr: 2.844 ± 0.08
0.0LeuXaa: 0.0 ± 0.0
Met
2.257MetAla: 2.257 ± 0.066
0.334MetCys: 0.334 ± 0.024
1.637MetAsp: 1.637 ± 0.06
1.918MetGlu: 1.918 ± 0.064
1.062MetPhe: 1.062 ± 0.053
1.872MetGly: 1.872 ± 0.061
0.43MetHis: 0.43 ± 0.027
2.372MetIle: 2.372 ± 0.064
2.342MetLys: 2.342 ± 0.065
2.683MetLeu: 2.683 ± 0.069
0.884MetMet: 0.884 ± 0.047
1.581MetAsn: 1.581 ± 0.054
1.114MetPro: 1.114 ± 0.042
0.9MetGln: 0.9 ± 0.041
1.268MetArg: 1.268 ± 0.05
1.96MetSer: 1.96 ± 0.062
1.53MetThr: 1.53 ± 0.057
1.71MetVal: 1.71 ± 0.053
0.169MetTrp: 0.169 ± 0.019
0.868MetTyr: 0.868 ± 0.039
0.0MetXaa: 0.0 ± 0.0
Asn
3.134AsnAla: 3.134 ± 0.076
0.613AsnCys: 0.613 ± 0.039
2.472AsnAsp: 2.472 ± 0.059
3.272AsnGlu: 3.272 ± 0.082
2.073AsnPhe: 2.073 ± 0.06
3.507AsnGly: 3.507 ± 0.09
0.763AsnHis: 0.763 ± 0.035
4.475AsnIle: 4.475 ± 0.095
3.967AsnLys: 3.967 ± 0.095
4.274AsnLeu: 4.274 ± 0.097
1.396AsnMet: 1.396 ± 0.054
2.293AsnAsn: 2.293 ± 0.077
2.141AsnPro: 2.141 ± 0.069
1.329AsnGln: 1.329 ± 0.056
2.058AsnArg: 2.058 ± 0.067
2.879AsnSer: 2.879 ± 0.09
2.54AsnThr: 2.54 ± 0.075
3.058AsnVal: 3.058 ± 0.085
0.423AsnTrp: 0.423 ± 0.026
1.935AsnTyr: 1.935 ± 0.063
0.0AsnXaa: 0.0 ± 0.0
Pro
1.995ProAla: 1.995 ± 0.063
0.367ProCys: 0.367 ± 0.027
1.927ProAsp: 1.927 ± 0.07
2.772ProGlu: 2.772 ± 0.072
1.46ProPhe: 1.46 ± 0.053
2.077ProGly: 2.077 ± 0.07
0.552ProHis: 0.552 ± 0.032
2.344ProIle: 2.344 ± 0.071
2.281ProLys: 2.281 ± 0.061
2.501ProLeu: 2.501 ± 0.071
0.828ProMet: 0.828 ± 0.039
1.528ProAsn: 1.528 ± 0.047
0.671ProPro: 0.671 ± 0.042
0.837ProGln: 0.837 ± 0.042
1.013ProArg: 1.013 ± 0.042
1.876ProSer: 1.876 ± 0.064
1.45ProThr: 1.45 ± 0.055
2.417ProVal: 2.417 ± 0.068
0.239ProTrp: 0.239 ± 0.021
1.284ProTyr: 1.284 ± 0.057
0.0ProXaa: 0.0 ± 0.0
Gln
1.766GlnAla: 1.766 ± 0.061
0.267GlnCys: 0.267 ± 0.023
1.193GlnAsp: 1.193 ± 0.041
1.703GlnGlu: 1.703 ± 0.058
0.943GlnPhe: 0.943 ± 0.04
1.659GlnGly: 1.659 ± 0.058
0.328GlnHis: 0.328 ± 0.025
2.059GlnIle: 2.059 ± 0.065
2.093GlnLys: 2.093 ± 0.064
2.059GlnLeu: 2.059 ± 0.075
0.837GlnMet: 0.837 ± 0.041
1.319GlnAsn: 1.319 ± 0.042
0.62GlnPro: 0.62 ± 0.041
0.669GlnGln: 0.669 ± 0.049
1.207GlnArg: 1.207 ± 0.046
1.511GlnSer: 1.511 ± 0.053
1.123GlnThr: 1.123 ± 0.046
1.46GlnVal: 1.46 ± 0.056
0.206GlnTrp: 0.206 ± 0.02
0.924GlnTyr: 0.924 ± 0.036
0.0GlnXaa: 0.0 ± 0.0
Arg
2.746ArgAla: 2.746 ± 0.072
0.501ArgCys: 0.501 ± 0.033
2.445ArgAsp: 2.445 ± 0.071
3.39ArgGlu: 3.39 ± 0.094
1.811ArgPhe: 1.811 ± 0.064
2.587ArgGly: 2.587 ± 0.064
0.688ArgHis: 0.688 ± 0.034
3.537ArgIle: 3.537 ± 0.089
3.603ArgLys: 3.603 ± 0.089
3.792ArgLeu: 3.792 ± 0.104
1.282ArgMet: 1.282 ± 0.048
2.293ArgAsn: 2.293 ± 0.077
1.198ArgPro: 1.198 ± 0.057
1.212ArgGln: 1.212 ± 0.043
2.15ArgArg: 2.15 ± 0.072
2.271ArgSer: 2.271 ± 0.064
1.899ArgThr: 1.899 ± 0.065
2.665ArgVal: 2.665 ± 0.076
0.29ArgTrp: 0.29 ± 0.024
1.759ArgTyr: 1.759 ± 0.058
0.0ArgXaa: 0.0 ± 0.0
Ser
4.451SerAla: 4.451 ± 0.096
0.734SerCys: 0.734 ± 0.038
3.944SerAsp: 3.944 ± 0.1
4.658SerGlu: 4.658 ± 0.11
3.132SerPhe: 3.132 ± 0.07
5.378SerGly: 5.378 ± 0.107
0.978SerHis: 0.978 ± 0.048
5.312SerIle: 5.312 ± 0.116
5.554SerLys: 5.554 ± 0.094
5.715SerLeu: 5.715 ± 0.115
1.822SerMet: 1.822 ± 0.056
2.856SerAsn: 2.856 ± 0.079
1.679SerPro: 1.679 ± 0.061
1.479SerGln: 1.479 ± 0.056
2.527SerArg: 2.527 ± 0.072
4.098SerSer: 4.098 ± 0.108
2.805SerThr: 2.805 ± 0.075
4.384SerVal: 4.384 ± 0.094
0.442SerTrp: 0.442 ± 0.028
2.576SerTyr: 2.576 ± 0.064
0.0SerXaa: 0.0 ± 0.0
Thr
3.806ThrAla: 3.806 ± 0.08
0.557ThrCys: 0.557 ± 0.031
3.092ThrAsp: 3.092 ± 0.075
3.324ThrGlu: 3.324 ± 0.085
1.895ThrPhe: 1.895 ± 0.061
4.094ThrGly: 4.094 ± 0.095
0.79ThrHis: 0.79 ± 0.041
4.031ThrIle: 4.031 ± 0.095
3.546ThrLys: 3.546 ± 0.087
4.244ThrLeu: 4.244 ± 0.093
1.231ThrMet: 1.231 ± 0.049
2.093ThrAsn: 2.093 ± 0.08
1.962ThrPro: 1.962 ± 0.062
1.174ThrGln: 1.174 ± 0.046
1.743ThrArg: 1.743 ± 0.054
3.057ThrSer: 3.057 ± 0.081
2.451ThrThr: 2.451 ± 0.095
4.129ThrVal: 4.129 ± 0.106
0.349ThrTrp: 0.349 ± 0.027
1.762ThrTyr: 1.762 ± 0.053
0.0ThrXaa: 0.0 ± 0.0
Val
4.548ValAla: 4.548 ± 0.125
1.064ValCys: 1.064 ± 0.048
3.944ValAsp: 3.944 ± 0.08
4.419ValGlu: 4.419 ± 0.093
3.086ValPhe: 3.086 ± 0.093
4.168ValGly: 4.168 ± 0.099
0.943ValHis: 0.943 ± 0.041
5.575ValIle: 5.575 ± 0.102
5.168ValLys: 5.168 ± 0.102
6.061ValLeu: 6.061 ± 0.102
1.895ValMet: 1.895 ± 0.059
3.324ValAsn: 3.324 ± 0.085
2.122ValPro: 2.122 ± 0.065
1.472ValGln: 1.472 ± 0.054
2.611ValArg: 2.611 ± 0.076
5.044ValSer: 5.044 ± 0.103
3.42ValThr: 3.42 ± 0.087
4.552ValVal: 4.552 ± 0.103
0.447ValTrp: 0.447 ± 0.028
2.353ValTyr: 2.353 ± 0.063
0.0ValXaa: 0.0 ± 0.0
Trp
0.414TrpAla: 0.414 ± 0.029
0.126TrpCys: 0.126 ± 0.017
0.426TrpAsp: 0.426 ± 0.025
0.466TrpGlu: 0.466 ± 0.03
0.321TrpPhe: 0.321 ± 0.027
0.472TrpGly: 0.472 ± 0.031
0.143TrpHis: 0.143 ± 0.019
0.611TrpIle: 0.611 ± 0.037
0.583TrpLys: 0.583 ± 0.033
0.664TrpLeu: 0.664 ± 0.037
0.232TrpMet: 0.232 ± 0.021
0.507TrpAsn: 0.507 ± 0.035
0.176TrpPro: 0.176 ± 0.017
0.253TrpGln: 0.253 ± 0.02
0.293TrpArg: 0.293 ± 0.023
0.419TrpSer: 0.419 ± 0.028
0.384TrpThr: 0.384 ± 0.027
0.376TrpVal: 0.376 ± 0.03
0.054TrpTrp: 0.054 ± 0.01
0.325TrpTyr: 0.325 ± 0.024
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.424TyrAla: 2.424 ± 0.073
0.596TyrCys: 0.596 ± 0.04
2.477TyrAsp: 2.477 ± 0.068
2.632TyrGlu: 2.632 ± 0.069
1.755TyrPhe: 1.755 ± 0.053
2.872TyrGly: 2.872 ± 0.07
0.632TyrHis: 0.632 ± 0.032
3.261TyrIle: 3.261 ± 0.084
3.034TyrLys: 3.034 ± 0.076
3.408TyrLeu: 3.408 ± 0.09
1.036TyrMet: 1.036 ± 0.043
1.81TyrAsn: 1.81 ± 0.063
1.207TyrPro: 1.207 ± 0.048
0.877TyrGln: 0.877 ± 0.036
1.818TyrArg: 1.818 ± 0.062
2.454TyrSer: 2.454 ± 0.077
2.017TyrThr: 2.017 ± 0.067
2.353TyrVal: 2.353 ± 0.07
0.3TyrTrp: 0.3 ± 0.022
1.476TyrTyr: 1.476 ± 0.055
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.002XaaIle: 0.002 ± 0.002
0.002XaaLys: 0.002 ± 0.002
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 1765 proteins (572512 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski