Amino acid dipepetide frequency for Corynebacterium atypicum

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
18.956AlaAla: 18.956 ± 0.364
1.071AlaCys: 1.071 ± 0.048
7.707AlaAsp: 7.707 ± 0.13
9.456AlaGlu: 9.456 ± 0.168
3.613AlaPhe: 3.613 ± 0.095
12.446AlaGly: 12.446 ± 0.216
2.724AlaHis: 2.724 ± 0.088
5.204AlaIle: 5.204 ± 0.122
3.769AlaLys: 3.769 ± 0.102
11.698AlaLeu: 11.698 ± 0.197
2.612AlaMet: 2.612 ± 0.075
2.57AlaAsn: 2.57 ± 0.071
5.534AlaPro: 5.534 ± 0.128
5.166AlaGln: 5.166 ± 0.113
9.35AlaArg: 9.35 ± 0.185
6.174AlaSer: 6.174 ± 0.132
6.79AlaThr: 6.79 ± 0.135
10.208AlaVal: 10.208 ± 0.177
1.527AlaTrp: 1.527 ± 0.06
2.251AlaTyr: 2.251 ± 0.076
0.0AlaXaa: 0.0 ± 0.0
Cys
1.063CysAla: 1.063 ± 0.057
0.077CysCys: 0.077 ± 0.015
0.451CysAsp: 0.451 ± 0.028
0.423CysGlu: 0.423 ± 0.027
0.236CysPhe: 0.236 ± 0.023
0.892CysGly: 0.892 ± 0.041
0.161CysHis: 0.161 ± 0.02
0.262CysIle: 0.262 ± 0.025
0.144CysLys: 0.144 ± 0.018
0.606CysLeu: 0.606 ± 0.029
0.11CysMet: 0.11 ± 0.015
0.159CysAsn: 0.159 ± 0.018
0.512CysPro: 0.512 ± 0.033
0.289CysGln: 0.289 ± 0.025
0.429CysArg: 0.429 ± 0.033
0.441CysSer: 0.441 ± 0.032
0.461CysThr: 0.461 ± 0.034
0.59CysVal: 0.59 ± 0.034
0.106CysTrp: 0.106 ± 0.015
0.175CysTyr: 0.175 ± 0.021
0.0CysXaa: 0.0 ± 0.0
Asp
7.923AspAla: 7.923 ± 0.144
0.411AspCys: 0.411 ± 0.032
3.369AspAsp: 3.369 ± 0.095
4.245AspGlu: 4.245 ± 0.103
2.139AspPhe: 2.139 ± 0.075
4.92AspGly: 4.92 ± 0.102
1.352AspHis: 1.352 ± 0.057
2.56AspIle: 2.56 ± 0.078
1.862AspLys: 1.862 ± 0.074
5.505AspLeu: 5.505 ± 0.106
1.049AspMet: 1.049 ± 0.046
1.374AspAsn: 1.374 ± 0.057
4.164AspPro: 4.164 ± 0.112
2.041AspGln: 2.041 ± 0.066
3.743AspArg: 3.743 ± 0.092
2.917AspSer: 2.917 ± 0.088
2.978AspThr: 2.978 ± 0.081
4.851AspVal: 4.851 ± 0.102
0.854AspTrp: 0.854 ± 0.045
1.466AspTyr: 1.466 ± 0.058
0.0AspXaa: 0.0 ± 0.0
Glu
7.481GluAla: 7.481 ± 0.149
0.396GluCys: 0.396 ± 0.033
3.527GluAsp: 3.527 ± 0.105
4.373GluGlu: 4.373 ± 0.114
2.263GluPhe: 2.263 ± 0.064
4.552GluGly: 4.552 ± 0.099
1.722GluHis: 1.722 ± 0.056
3.271GluIle: 3.271 ± 0.077
2.456GluLys: 2.456 ± 0.089
7.756GluLeu: 7.756 ± 0.148
1.258GluMet: 1.258 ± 0.058
1.734GluAsn: 1.734 ± 0.061
3.052GluPro: 3.052 ± 0.083
2.494GluGln: 2.494 ± 0.082
4.895GluArg: 4.895 ± 0.109
2.899GluSer: 2.899 ± 0.077
3.001GluThr: 3.001 ± 0.085
5.794GluVal: 5.794 ± 0.133
0.657GluTrp: 0.657 ± 0.039
1.354GluTyr: 1.354 ± 0.055
0.0GluXaa: 0.0 ± 0.0
Phe
4.017PheAla: 4.017 ± 0.087
0.297PheCys: 0.297 ± 0.023
2.409PheAsp: 2.409 ± 0.073
1.86PheGlu: 1.86 ± 0.069
1.277PhePhe: 1.277 ± 0.061
3.478PheGly: 3.478 ± 0.092
0.681PheHis: 0.681 ± 0.037
1.496PheIle: 1.496 ± 0.071
0.752PheLys: 0.752 ± 0.041
2.765PheLeu: 2.765 ± 0.077
0.579PheMet: 0.579 ± 0.034
0.935PheAsn: 0.935 ± 0.045
1.334PhePro: 1.334 ± 0.055
0.858PheGln: 0.858 ± 0.041
1.669PheArg: 1.669 ± 0.06
2.214PheSer: 2.214 ± 0.072
1.984PheThr: 1.984 ± 0.063
2.543PheVal: 2.543 ± 0.076
0.413PheTrp: 0.413 ± 0.03
0.732PheTyr: 0.732 ± 0.036
0.0PheXaa: 0.0 ± 0.0
Gly
9.982GlyAla: 9.982 ± 0.175
0.793GlyCys: 0.793 ± 0.041
4.546GlyAsp: 4.546 ± 0.106
5.924GlyGlu: 5.924 ± 0.111
3.186GlyPhe: 3.186 ± 0.081
7.459GlyGly: 7.459 ± 0.154
1.95GlyHis: 1.95 ± 0.064
4.162GlyIle: 4.162 ± 0.096
3.269GlyLys: 3.269 ± 0.085
8.514GlyLeu: 8.514 ± 0.153
2.098GlyMet: 2.098 ± 0.055
2.139GlyAsn: 2.139 ± 0.071
3.72GlyPro: 3.72 ± 0.097
3.135GlyGln: 3.135 ± 0.089
5.892GlyArg: 5.892 ± 0.106
4.765GlySer: 4.765 ± 0.097
5.087GlyThr: 5.087 ± 0.106
7.449GlyVal: 7.449 ± 0.137
1.334GlyTrp: 1.334 ± 0.052
2.133GlyTyr: 2.133 ± 0.071
0.0GlyXaa: 0.0 ± 0.0
His
2.222HisAla: 2.222 ± 0.061
0.163HisCys: 0.163 ± 0.02
1.234HisAsp: 1.234 ± 0.057
1.328HisGlu: 1.328 ± 0.047
0.655HisPhe: 0.655 ± 0.037
1.966HisGly: 1.966 ± 0.059
0.539HisHis: 0.539 ± 0.035
0.846HisIle: 0.846 ± 0.042
0.496HisLys: 0.496 ± 0.026
1.976HisLeu: 1.976 ± 0.065
0.382HisMet: 0.382 ± 0.028
0.557HisAsn: 0.557 ± 0.038
1.657HisPro: 1.657 ± 0.058
0.795HisGln: 0.795 ± 0.037
1.702HisArg: 1.702 ± 0.058
1.059HisSer: 1.059 ± 0.049
1.248HisThr: 1.248 ± 0.055
1.673HisVal: 1.673 ± 0.057
0.285HisTrp: 0.285 ± 0.025
0.529HisTyr: 0.529 ± 0.036
0.0HisXaa: 0.0 ± 0.0
Ile
6.312IleAla: 6.312 ± 0.113
0.396IleCys: 0.396 ± 0.032
3.458IleAsp: 3.458 ± 0.085
3.039IleGlu: 3.039 ± 0.088
1.468IlePhe: 1.468 ± 0.063
3.997IleGly: 3.997 ± 0.107
0.836IleHis: 0.836 ± 0.042
2.086IleIle: 2.086 ± 0.086
1.273IleLys: 1.273 ± 0.053
3.501IleLeu: 3.501 ± 0.089
0.773IleMet: 0.773 ± 0.047
1.234IleAsn: 1.234 ± 0.052
2.299IlePro: 2.299 ± 0.06
1.159IleGln: 1.159 ± 0.05
2.434IleArg: 2.434 ± 0.072
2.592IleSer: 2.592 ± 0.077
3.011IleThr: 3.011 ± 0.088
3.946IleVal: 3.946 ± 0.095
0.502IleTrp: 0.502 ± 0.034
0.937IleTyr: 0.937 ± 0.043
0.0IleXaa: 0.0 ± 0.0
Lys
3.81LysAla: 3.81 ± 0.096
0.13LysCys: 0.13 ± 0.014
1.698LysAsp: 1.698 ± 0.064
1.836LysGlu: 1.836 ± 0.068
0.831LysPhe: 0.831 ± 0.042
2.169LysGly: 2.169 ± 0.08
0.632LysHis: 0.632 ± 0.041
1.513LysIle: 1.513 ± 0.056
1.708LysLys: 1.708 ± 0.089
3.157LysLeu: 3.157 ± 0.081
0.679LysMet: 0.679 ± 0.036
0.988LysAsn: 0.988 ± 0.055
1.653LysPro: 1.653 ± 0.07
1.012LysGln: 1.012 ± 0.042
2.015LysArg: 2.015 ± 0.069
1.541LysSer: 1.541 ± 0.058
1.722LysThr: 1.722 ± 0.067
2.56LysVal: 2.56 ± 0.076
0.333LysTrp: 0.333 ± 0.024
0.651LysTyr: 0.651 ± 0.04
0.0LysXaa: 0.0 ± 0.0
Leu
13.53LeuAla: 13.53 ± 0.225
0.701LeuCys: 0.701 ± 0.042
6.396LeuAsp: 6.396 ± 0.137
5.414LeuGlu: 5.414 ± 0.112
2.686LeuPhe: 2.686 ± 0.085
8.612LeuGly: 8.612 ± 0.151
1.84LeuHis: 1.84 ± 0.062
4.54LeuIle: 4.54 ± 0.1
2.799LeuLys: 2.799 ± 0.089
7.943LeuLeu: 7.943 ± 0.156
1.789LeuMet: 1.789 ± 0.063
2.326LeuAsn: 2.326 ± 0.064
5.066LeuPro: 5.066 ± 0.101
2.389LeuGln: 2.389 ± 0.073
6.211LeuArg: 6.211 ± 0.128
5.595LeuSer: 5.595 ± 0.105
5.633LeuThr: 5.633 ± 0.131
7.931LeuVal: 7.931 ± 0.144
0.982LeuTrp: 0.982 ± 0.04
1.675LeuTyr: 1.675 ± 0.061
0.0LeuXaa: 0.0 ± 0.0
Met
2.694MetAla: 2.694 ± 0.068
0.146MetCys: 0.146 ± 0.017
1.039MetAsp: 1.039 ± 0.046
0.929MetGlu: 0.929 ± 0.038
0.563MetPhe: 0.563 ± 0.035
1.555MetGly: 1.555 ± 0.057
0.388MetHis: 0.388 ± 0.027
0.984MetIle: 0.984 ± 0.048
0.551MetLys: 0.551 ± 0.037
1.872MetLeu: 1.872 ± 0.064
0.384MetMet: 0.384 ± 0.029
0.604MetAsn: 0.604 ± 0.032
1.104MetPro: 1.104 ± 0.047
0.604MetGln: 0.604 ± 0.033
1.515MetArg: 1.515 ± 0.056
1.549MetSer: 1.549 ± 0.055
1.502MetThr: 1.502 ± 0.049
1.606MetVal: 1.606 ± 0.059
0.215MetTrp: 0.215 ± 0.018
0.335MetTyr: 0.335 ± 0.027
0.0MetXaa: 0.0 ± 0.0
Asn
2.787AsnAla: 2.787 ± 0.077
0.177AsnCys: 0.177 ± 0.02
1.248AsnAsp: 1.248 ± 0.058
1.352AsnGlu: 1.352 ± 0.058
0.813AsnPhe: 0.813 ± 0.038
1.828AsnGly: 1.828 ± 0.069
0.525AsnHis: 0.525 ± 0.034
1.157AsnIle: 1.157 ± 0.057
0.771AsnLys: 0.771 ± 0.04
2.421AsnLeu: 2.421 ± 0.08
0.549AsnMet: 0.549 ± 0.033
0.683AsnAsn: 0.683 ± 0.038
1.96AsnPro: 1.96 ± 0.074
0.905AsnGln: 0.905 ± 0.054
1.663AsnArg: 1.663 ± 0.065
1.372AsnSer: 1.372 ± 0.048
1.319AsnThr: 1.319 ± 0.052
1.921AsnVal: 1.921 ± 0.063
0.384AsnTrp: 0.384 ± 0.028
0.644AsnTyr: 0.644 ± 0.036
0.0AsnXaa: 0.0 ± 0.0
Pro
6.76ProAla: 6.76 ± 0.146
0.26ProCys: 0.26 ± 0.023
3.34ProAsp: 3.34 ± 0.091
4.69ProGlu: 4.69 ± 0.111
1.553ProPhe: 1.553 ± 0.057
5.231ProGly: 5.231 ± 0.116
1.108ProHis: 1.108 ± 0.047
1.893ProIle: 1.893 ± 0.059
1.598ProLys: 1.598 ± 0.068
4.005ProLeu: 4.005 ± 0.082
0.996ProMet: 0.996 ± 0.042
1.309ProAsn: 1.309 ± 0.054
1.982ProPro: 1.982 ± 0.087
2.057ProGln: 2.057 ± 0.071
3.263ProArg: 3.263 ± 0.099
2.647ProSer: 2.647 ± 0.076
2.901ProThr: 2.901 ± 0.079
4.605ProVal: 4.605 ± 0.094
0.63ProTrp: 0.63 ± 0.038
0.97ProTyr: 0.97 ± 0.049
0.0ProXaa: 0.0 ± 0.0
Gln
4.8GlnAla: 4.8 ± 0.107
0.191GlnCys: 0.191 ± 0.023
1.663GlnAsp: 1.663 ± 0.061
1.982GlnGlu: 1.982 ± 0.065
0.976GlnPhe: 0.976 ± 0.041
2.2GlnGly: 2.2 ± 0.064
0.703GlnHis: 0.703 ± 0.035
1.712GlnIle: 1.712 ± 0.06
0.988GlnLys: 0.988 ± 0.051
4.088GlnLeu: 4.088 ± 0.095
0.695GlnMet: 0.695 ± 0.034
0.766GlnAsn: 0.766 ± 0.042
1.952GlnPro: 1.952 ± 0.064
1.393GlnGln: 1.393 ± 0.058
2.582GlnArg: 2.582 ± 0.075
1.492GlnSer: 1.492 ± 0.058
1.657GlnThr: 1.657 ± 0.052
2.993GlnVal: 2.993 ± 0.077
0.563GlnTrp: 0.563 ± 0.038
0.649GlnTyr: 0.649 ± 0.044
0.0GlnXaa: 0.0 ± 0.0
Arg
8.256ArgAla: 8.256 ± 0.192
0.435ArgCys: 0.435 ± 0.034
3.853ArgAsp: 3.853 ± 0.089
4.601ArgGlu: 4.601 ± 0.102
2.385ArgPhe: 2.385 ± 0.066
5.432ArgGly: 5.432 ± 0.109
1.405ArgHis: 1.405 ± 0.058
3.243ArgIle: 3.243 ± 0.078
2.118ArgLys: 2.118 ± 0.074
6.662ArgLeu: 6.662 ± 0.135
1.775ArgMet: 1.775 ± 0.055
1.541ArgAsn: 1.541 ± 0.055
3.495ArgPro: 3.495 ± 0.09
2.401ArgGln: 2.401 ± 0.076
5.995ArgArg: 5.995 ± 0.146
3.531ArgSer: 3.531 ± 0.09
3.596ArgThr: 3.596 ± 0.093
5.339ArgVal: 5.339 ± 0.104
1.021ArgTrp: 1.021 ± 0.045
1.649ArgTyr: 1.649 ± 0.054
0.0ArgXaa: 0.0 ± 0.0
Ser
6.78SerAla: 6.78 ± 0.123
0.417SerCys: 0.417 ± 0.027
2.915SerAsp: 2.915 ± 0.075
3.088SerGlu: 3.088 ± 0.09
1.824SerPhe: 1.824 ± 0.062
5.696SerGly: 5.696 ± 0.115
1.108SerHis: 1.108 ± 0.047
2.143SerIle: 2.143 ± 0.074
1.486SerLys: 1.486 ± 0.058
4.56SerLeu: 4.56 ± 0.098
1.163SerMet: 1.163 ± 0.058
1.244SerAsn: 1.244 ± 0.055
2.86SerPro: 2.86 ± 0.087
1.931SerGln: 1.931 ± 0.058
3.647SerArg: 3.647 ± 0.09
3.18SerSer: 3.18 ± 0.091
3.1SerThr: 3.1 ± 0.077
4.192SerVal: 4.192 ± 0.106
0.986SerTrp: 0.986 ± 0.042
1.25SerTyr: 1.25 ± 0.053
0.0SerXaa: 0.0 ± 0.0
Thr
6.646ThrAla: 6.646 ± 0.127
0.453ThrCys: 0.453 ± 0.031
3.204ThrAsp: 3.204 ± 0.092
3.32ThrGlu: 3.32 ± 0.089
1.83ThrPhe: 1.83 ± 0.063
5.666ThrGly: 5.666 ± 0.117
1.147ThrHis: 1.147 ± 0.043
2.684ThrIle: 2.684 ± 0.087
1.588ThrLys: 1.588 ± 0.067
5.135ThrLeu: 5.135 ± 0.095
1.039ThrMet: 1.039 ± 0.05
1.387ThrAsn: 1.387 ± 0.059
3.395ThrPro: 3.395 ± 0.096
1.775ThrGln: 1.775 ± 0.058
3.34ThrArg: 3.34 ± 0.092
3.224ThrSer: 3.224 ± 0.084
3.485ThrThr: 3.485 ± 0.096
5.322ThrVal: 5.322 ± 0.115
0.775ThrTrp: 0.775 ± 0.039
1.232ThrTyr: 1.232 ± 0.049
0.0ThrXaa: 0.0 ± 0.0
Val
10.986ValAla: 10.986 ± 0.18
0.742ValCys: 0.742 ± 0.046
5.806ValAsp: 5.806 ± 0.109
5.233ValGlu: 5.233 ± 0.101
2.686ValPhe: 2.686 ± 0.072
6.678ValGly: 6.678 ± 0.138
1.807ValHis: 1.807 ± 0.059
4.127ValIle: 4.127 ± 0.108
2.151ValLys: 2.151 ± 0.061
8.008ValLeu: 8.008 ± 0.152
1.58ValMet: 1.58 ± 0.061
2.066ValAsn: 2.066 ± 0.073
4.196ValPro: 4.196 ± 0.092
2.037ValGln: 2.037 ± 0.058
5.479ValArg: 5.479 ± 0.116
4.513ValSer: 4.513 ± 0.097
5.369ValThr: 5.369 ± 0.116
7.963ValVal: 7.963 ± 0.169
1.021ValTrp: 1.021 ± 0.048
1.633ValTyr: 1.633 ± 0.063
0.0ValXaa: 0.0 ± 0.0
Trp
1.588TrpAla: 1.588 ± 0.064
0.136TrpCys: 0.136 ± 0.017
0.687TrpAsp: 0.687 ± 0.032
0.636TrpGlu: 0.636 ± 0.039
0.531TrpPhe: 0.531 ± 0.034
0.831TrpGly: 0.831 ± 0.044
0.268TrpHis: 0.268 ± 0.024
0.598TrpIle: 0.598 ± 0.037
0.368TrpLys: 0.368 ± 0.026
1.565TrpLeu: 1.565 ± 0.067
0.305TrpMet: 0.305 ± 0.022
0.358TrpAsn: 0.358 ± 0.029
0.604TrpPro: 0.604 ± 0.035
0.659TrpGln: 0.659 ± 0.034
1.153TrpArg: 1.153 ± 0.049
0.636TrpSer: 0.636 ± 0.034
0.649TrpThr: 0.649 ± 0.041
1.045TrpVal: 1.045 ± 0.055
0.307TrpTrp: 0.307 ± 0.029
0.303TrpTyr: 0.303 ± 0.026
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.232TyrAla: 2.232 ± 0.067
0.193TyrCys: 0.193 ± 0.02
1.173TyrAsp: 1.173 ± 0.05
1.208TyrGlu: 1.208 ± 0.051
0.783TyrPhe: 0.783 ± 0.042
1.925TyrGly: 1.925 ± 0.068
0.415TyrHis: 0.415 ± 0.027
0.775TyrIle: 0.775 ± 0.044
0.49TyrLys: 0.49 ± 0.036
2.318TyrLeu: 2.318 ± 0.083
0.323TyrMet: 0.323 ± 0.027
0.506TyrAsn: 0.506 ± 0.035
1.26TyrPro: 1.26 ± 0.056
0.945TyrGln: 0.945 ± 0.048
1.757TyrArg: 1.757 ± 0.068
1.228TyrSer: 1.228 ± 0.052
1.151TyrThr: 1.151 ± 0.053
1.551TyrVal: 1.551 ± 0.066
0.333TyrTrp: 0.333 ± 0.027
0.557TyrTyr: 0.557 ± 0.034
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 1533 proteins (491884 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski