Amino acid dipepetide frequency for Serpentinicella alkaliphila

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	3.92AlaAla: 3.92 ± 0.102	0.629AlaCys: 0.629 ± 0.028	2.476AlaAsp: 2.476 ± 0.06	3.61AlaGlu: 3.61 ± 0.077	2.581AlaPhe: 2.581 ± 0.055	4.035AlaGly: 4.035 ± 0.089	0.933AlaHis: 0.933 ± 0.033	6.333AlaIle: 6.333 ± 0.089	4.376AlaLys: 4.376 ± 0.078	6.147AlaLeu: 6.147 ± 0.093	1.724AlaMet: 1.724 ± 0.048	2.67AlaAsn: 2.67 ± 0.063	1.544AlaPro: 1.544 ± 0.053	1.658AlaGln: 1.658 ± 0.05	2.134AlaArg: 2.134 ± 0.056	3.334AlaSer: 3.334 ± 0.063	3.114AlaThr: 3.114 ± 0.068	4.14AlaVal: 4.14 ± 0.092	0.359AlaTrp: 0.359 ± 0.018	2.19AlaTyr: 2.19 ± 0.054	0.0AlaXaa: 0.0 ± 0.0
Cys	0.533CysAla: 0.533 ± 0.027	0.146CysCys: 0.146 ± 0.015	0.479CysAsp: 0.479 ± 0.029	0.554CysGlu: 0.554 ± 0.024	0.408CysPhe: 0.408 ± 0.021	0.827CysGly: 0.827 ± 0.038	0.223CysHis: 0.223 ± 0.017	0.895CysIle: 0.895 ± 0.038	0.685CysLys: 0.685 ± 0.032	0.78CysLeu: 0.78 ± 0.033	0.258CysMet: 0.258 ± 0.018	0.588CysAsn: 0.588 ± 0.029	0.483CysPro: 0.483 ± 0.028	0.245CysGln: 0.245 ± 0.019	0.353CysArg: 0.353 ± 0.021	0.657CysSer: 0.657 ± 0.024	0.453CysThr: 0.453 ± 0.023	0.568CysVal: 0.568 ± 0.028	0.07CysTrp: 0.07 ± 0.01	0.331CysTyr: 0.331 ± 0.02	0.0CysXaa: 0.0 ± 0.0
Asp	2.668AspAla: 2.668 ± 0.06	0.492AspCys: 0.492 ± 0.03	2.325AspAsp: 2.325 ± 0.057	4.214AspGlu: 4.214 ± 0.077	2.528AspPhe: 2.528 ± 0.056	3.086AspGly: 3.086 ± 0.061	0.697AspHis: 0.697 ± 0.029	5.965AspIle: 5.965 ± 0.074	4.289AspLys: 4.289 ± 0.073	4.959AspLeu: 4.959 ± 0.084	1.418AspMet: 1.418 ± 0.037	2.832AspAsn: 2.832 ± 0.069	1.5AspPro: 1.5 ± 0.04	1.162AspGln: 1.162 ± 0.036	2.064AspArg: 2.064 ± 0.051	2.899AspSer: 2.899 ± 0.062	2.409AspThr: 2.409 ± 0.058	3.562AspVal: 3.562 ± 0.072	0.386AspTrp: 0.386 ± 0.022	2.377AspTyr: 2.377 ± 0.056	0.0AspXaa: 0.0 ± 0.0
Glu	4.314GluAla: 4.314 ± 0.079	0.487GluCys: 0.487 ± 0.024	4.052GluAsp: 4.052 ± 0.072	6.444GluGlu: 6.444 ± 0.101	2.87GluPhe: 2.87 ± 0.061	4.289GluGly: 4.289 ± 0.076	1.109GluHis: 1.109 ± 0.039	7.557GluIle: 7.557 ± 0.105	6.574GluLys: 6.574 ± 0.103	7.22GluLeu: 7.22 ± 0.106	1.987GluMet: 1.987 ± 0.05	4.378GluAsn: 4.378 ± 0.073	1.577GluPro: 1.577 ± 0.045	2.395GluGln: 2.395 ± 0.057	2.847GluArg: 2.847 ± 0.062	3.738GluSer: 3.738 ± 0.059	3.126GluThr: 3.126 ± 0.065	5.329GluVal: 5.329 ± 0.085	0.446GluTrp: 0.446 ± 0.024	2.721GluTyr: 2.721 ± 0.064	0.0GluXaa: 0.0 ± 0.0
Phe	2.318PheAla: 2.318 ± 0.058	0.457PheCys: 0.457 ± 0.026	2.374PheAsp: 2.374 ± 0.057	2.835PheGlu: 2.835 ± 0.064	1.984PhePhe: 1.984 ± 0.055	2.961PheGly: 2.961 ± 0.065	0.681PheHis: 0.681 ± 0.029	4.552PheIle: 4.552 ± 0.086	3.161PheLys: 3.161 ± 0.065	3.972PheLeu: 3.972 ± 0.077	1.122PheMet: 1.122 ± 0.038	2.737PheAsn: 2.737 ± 0.057	1.349PhePro: 1.349 ± 0.04	1.065PheGln: 1.065 ± 0.035	1.452PheArg: 1.452 ± 0.049	2.97PheSer: 2.97 ± 0.061	2.446PheThr: 2.446 ± 0.062	2.856PheVal: 2.856 ± 0.071	0.292PheTrp: 0.292 ± 0.018	1.66PheTyr: 1.66 ± 0.051	0.0PheXaa: 0.0 ± 0.0
Gly	4.337GlyAla: 4.337 ± 0.106	0.84GlyCys: 0.84 ± 0.036	3.103GlyAsp: 3.103 ± 0.066	4.052GlyGlu: 4.052 ± 0.076	3.234GlyPhe: 3.234 ± 0.063	4.551GlyGly: 4.551 ± 0.094	1.223GlyHis: 1.223 ± 0.043	6.969GlyIle: 6.969 ± 0.1	4.819GlyLys: 4.819 ± 0.082	6.223GlyLeu: 6.223 ± 0.095	1.825GlyMet: 1.825 ± 0.054	3.133GlyAsn: 3.133 ± 0.067	1.516GlyPro: 1.516 ± 0.047	1.849GlyGln: 1.849 ± 0.042	2.569GlyArg: 2.569 ± 0.06	3.73GlySer: 3.73 ± 0.073	3.704GlyThr: 3.704 ± 0.073	4.806GlyVal: 4.806 ± 0.079	0.486GlyTrp: 0.486 ± 0.022	2.888GlyTyr: 2.888 ± 0.059	0.0GlyXaa: 0.0 ± 0.0
His	0.76HisAla: 0.76 ± 0.03	0.18HisCys: 0.18 ± 0.014	0.731HisAsp: 0.731 ± 0.03	1.032HisGlu: 1.032 ± 0.035	0.706HisPhe: 0.706 ± 0.029	1.123HisGly: 1.123 ± 0.038	0.378HisHis: 0.378 ± 0.021	1.612HisIle: 1.612 ± 0.045	1.11HisLys: 1.11 ± 0.041	1.517HisLeu: 1.517 ± 0.05	0.442HisMet: 0.442 ± 0.024	0.931HisAsn: 0.931 ± 0.033	0.751HisPro: 0.751 ± 0.035	0.455HisGln: 0.455 ± 0.024	0.738HisArg: 0.738 ± 0.029	1.061HisSer: 1.061 ± 0.033	0.842HisThr: 0.842 ± 0.031	0.879HisVal: 0.879 ± 0.029	0.132HisTrp: 0.132 ± 0.012	0.625HisTyr: 0.625 ± 0.025	0.0HisXaa: 0.0 ± 0.0
Ile	6.222IleAla: 6.222 ± 0.089	0.969IleCys: 0.969 ± 0.041	5.719IleAsp: 5.719 ± 0.082	7.554IleGlu: 7.554 ± 0.11	4.015IlePhe: 4.015 ± 0.071	6.515IleGly: 6.515 ± 0.103	1.495IleHis: 1.495 ± 0.045	9.575IleIle: 9.575 ± 0.136	7.666IleLys: 7.666 ± 0.111	9.106IleLeu: 9.106 ± 0.126	2.379IleMet: 2.379 ± 0.06	6.238IleAsn: 6.238 ± 0.095	3.641IlePro: 3.641 ± 0.069	2.601IleGln: 2.601 ± 0.053	3.604IleArg: 3.604 ± 0.064	6.704IleSer: 6.704 ± 0.102	5.317IleThr: 5.317 ± 0.093	7.053IleVal: 7.053 ± 0.097	0.588IleTrp: 0.588 ± 0.03	3.584IleTyr: 3.584 ± 0.072	0.0IleXaa: 0.0 ± 0.0
Lys	4.442LysAla: 4.442 ± 0.062	0.608LysCys: 0.608 ± 0.026	4.665LysAsp: 4.665 ± 0.088	7.413LysGlu: 7.413 ± 0.099	2.556LysPhe: 2.556 ± 0.058	4.715LysGly: 4.715 ± 0.074	1.306LysHis: 1.306 ± 0.041	7.098LysIle: 7.098 ± 0.099	6.319LysLys: 6.319 ± 0.098	7.071LysLeu: 7.071 ± 0.095	2.107LysMet: 2.107 ± 0.048	4.764LysAsn: 4.764 ± 0.079	2.153LysPro: 2.153 ± 0.044	2.346LysGln: 2.346 ± 0.054	3.003LysArg: 3.003 ± 0.065	4.483LysSer: 4.483 ± 0.068	3.798LysThr: 3.798 ± 0.067	5.332LysVal: 5.332 ± 0.089	0.527LysTrp: 0.527 ± 0.028	3.346LysTyr: 3.346 ± 0.065	0.0LysXaa: 0.0 ± 0.0
Leu	5.645LeuAla: 5.645 ± 0.093	0.888LeuCys: 0.888 ± 0.033	5.133LeuAsp: 5.133 ± 0.082	6.795LeuGlu: 6.795 ± 0.106	4.137LeuPhe: 4.137 ± 0.075	6.768LeuGly: 6.768 ± 0.112	1.408LeuHis: 1.408 ± 0.043	8.908LeuIle: 8.908 ± 0.112	7.544LeuLys: 7.544 ± 0.108	9.168LeuLeu: 9.168 ± 0.142	2.448LeuMet: 2.448 ± 0.055	5.928LeuAsn: 5.928 ± 0.082	3.029LeuPro: 3.029 ± 0.064	2.518LeuGln: 2.518 ± 0.056	3.583LeuArg: 3.583 ± 0.064	6.594LeuSer: 6.594 ± 0.098	4.835LeuThr: 4.835 ± 0.075	6.309LeuVal: 6.309 ± 0.087	0.574LeuTrp: 0.574 ± 0.028	3.053LeuTyr: 3.053 ± 0.062	0.0LeuXaa: 0.0 ± 0.0
Met	1.744MetAla: 1.744 ± 0.047	0.192MetCys: 0.192 ± 0.014	1.496MetAsp: 1.496 ± 0.041	1.883MetGlu: 1.883 ± 0.051	1.036MetPhe: 1.036 ± 0.03	1.815MetGly: 1.815 ± 0.052	0.408MetHis: 0.408 ± 0.021	2.225MetIle: 2.225 ± 0.053	2.366MetLys: 2.366 ± 0.047	2.395MetLeu: 2.395 ± 0.054	0.694MetMet: 0.694 ± 0.035	1.609MetAsn: 1.609 ± 0.039	0.994MetPro: 0.994 ± 0.038	0.704MetGln: 0.704 ± 0.026	1.05MetArg: 1.05 ± 0.033	1.69MetSer: 1.69 ± 0.048	1.347MetThr: 1.347 ± 0.038	1.756MetVal: 1.756 ± 0.044	0.133MetTrp: 0.133 ± 0.012	0.773MetTyr: 0.773 ± 0.029	0.0MetXaa: 0.0 ± 0.0
Asn	2.685AsnAla: 2.685 ± 0.054	0.567AsnCys: 0.567 ± 0.031	2.693AsnAsp: 2.693 ± 0.057	4.118AsnGlu: 4.118 ± 0.069	2.298AsnPhe: 2.298 ± 0.058	3.296AsnGly: 3.296 ± 0.073	0.934AsnHis: 0.934 ± 0.037	6.68AsnIle: 6.68 ± 0.102	5.021AsnLys: 5.021 ± 0.085	5.325AsnLeu: 5.325 ± 0.08	1.628AsnMet: 1.628 ± 0.043	3.982AsnAsn: 3.982 ± 0.084	2.197AsnPro: 2.197 ± 0.054	1.691AsnGln: 1.691 ± 0.044	2.486AsnArg: 2.486 ± 0.055	3.629AsnSer: 3.629 ± 0.069	2.809AsnThr: 2.809 ± 0.059	3.489AsnVal: 3.489 ± 0.068	0.391AsnTrp: 0.391 ± 0.022	2.446AsnTyr: 2.446 ± 0.054	0.0AsnXaa: 0.0 ± 0.0
Pro	1.602ProAla: 1.602 ± 0.053	0.294ProCys: 0.294 ± 0.02	1.536ProAsp: 1.536 ± 0.047	2.405ProGlu: 2.405 ± 0.063	1.467ProPhe: 1.467 ± 0.041	2.13ProGly: 2.13 ± 0.056	0.597ProHis: 0.597 ± 0.025	3.15ProIle: 3.15 ± 0.064	2.166ProLys: 2.166 ± 0.052	2.87ProLeu: 2.87 ± 0.052	0.735ProMet: 0.735 ± 0.031	1.67ProAsn: 1.67 ± 0.05	0.865ProPro: 0.865 ± 0.034	0.991ProGln: 0.991 ± 0.033	1.055ProArg: 1.055 ± 0.037	1.831ProSer: 1.831 ± 0.056	1.8ProThr: 1.8 ± 0.047	2.298ProVal: 2.298 ± 0.057	0.258ProTrp: 0.258 ± 0.021	1.295ProTyr: 1.295 ± 0.041	0.0ProXaa: 0.0 ± 0.0
Gln	1.667GlnAla: 1.667 ± 0.048	0.227GlnCys: 0.227 ± 0.015	1.251GlnAsp: 1.251 ± 0.036	2.071GlnGlu: 2.071 ± 0.052	1.202GlnPhe: 1.202 ± 0.037	1.552GlnGly: 1.552 ± 0.037	0.463GlnHis: 0.463 ± 0.024	2.545GlnIle: 2.545 ± 0.054	2.18GlnLys: 2.18 ± 0.05	2.902GlnLeu: 2.902 ± 0.058	0.89GlnMet: 0.89 ± 0.033	1.702GlnAsn: 1.702 ± 0.045	0.76GlnPro: 0.76 ± 0.029	1.085GlnGln: 1.085 ± 0.042	1.201GlnArg: 1.201 ± 0.037	1.685GlnSer: 1.685 ± 0.047	1.258GlnThr: 1.258 ± 0.035	1.875GlnVal: 1.875 ± 0.051	0.257GlnTrp: 0.257 ± 0.017	1.121GlnTyr: 1.121 ± 0.036	0.0GlnXaa: 0.0 ± 0.0
Arg	2.161ArgAla: 2.161 ± 0.053	0.341ArgCys: 0.341 ± 0.021	2.091ArgAsp: 2.091 ± 0.044	3.037ArgGlu: 3.037 ± 0.07	1.688ArgPhe: 1.688 ± 0.052	2.491ArgGly: 2.491 ± 0.057	0.592ArgHis: 0.592 ± 0.023	3.634ArgIle: 3.634 ± 0.074	3.073ArgLys: 3.073 ± 0.062	3.638ArgLeu: 3.638 ± 0.068	1.058ArgMet: 1.058 ± 0.036	2.201ArgAsn: 2.201 ± 0.051	1.162ArgPro: 1.162 ± 0.039	1.191ArgGln: 1.191 ± 0.04	1.731ArgArg: 1.731 ± 0.055	1.929ArgSer: 1.929 ± 0.05	1.83ArgThr: 1.83 ± 0.044	2.709ArgVal: 2.709 ± 0.063	0.286ArgTrp: 0.286 ± 0.016	1.478ArgTyr: 1.478 ± 0.043	0.0ArgXaa: 0.0 ± 0.0
Ser	3.093SerAla: 3.093 ± 0.068	0.539SerCys: 0.539 ± 0.026	2.919SerAsp: 2.919 ± 0.059	3.949SerGlu: 3.949 ± 0.071	2.961SerPhe: 2.961 ± 0.055	4.075SerGly: 4.075 ± 0.072	1.04SerHis: 1.04 ± 0.037	6.659SerIle: 6.659 ± 0.103	4.908SerLys: 4.908 ± 0.084	6.118SerLeu: 6.118 ± 0.09	1.602SerMet: 1.602 ± 0.038	3.648SerAsn: 3.648 ± 0.074	1.849SerPro: 1.849 ± 0.048	1.812SerGln: 1.812 ± 0.05	2.306SerArg: 2.306 ± 0.049	3.978SerSer: 3.978 ± 0.078	3.185SerThr: 3.185 ± 0.061	4.06SerVal: 4.06 ± 0.071	0.46SerTrp: 0.46 ± 0.023	2.301SerTyr: 2.301 ± 0.051	0.0SerXaa: 0.0 ± 0.0
Thr	3.053ThrAla: 3.053 ± 0.068	0.46ThrCys: 0.46 ± 0.026	2.464ThrAsp: 2.464 ± 0.052	3.334ThrGlu: 3.334 ± 0.058	2.256ThrPhe: 2.256 ± 0.049	3.933ThrGly: 3.933 ± 0.078	0.846ThrHis: 0.846 ± 0.032	5.144ThrIle: 5.144 ± 0.077	3.535ThrLys: 3.535 ± 0.076	4.987ThrLeu: 4.987 ± 0.089	1.186ThrMet: 1.186 ± 0.037	2.882ThrAsn: 2.882 ± 0.072	1.984ThrPro: 1.984 ± 0.054	1.307ThrGln: 1.307 ± 0.041	1.83ThrArg: 1.83 ± 0.05	3.164ThrSer: 3.164 ± 0.062	3.016ThrThr: 3.016 ± 0.071	3.697ThrVal: 3.697 ± 0.081	0.371ThrTrp: 0.371 ± 0.021	1.881ThrTyr: 1.881 ± 0.047	0.0ThrXaa: 0.0 ± 0.0
Val	4.45ValAla: 4.45 ± 0.083	0.694ValCys: 0.694 ± 0.032	3.884ValAsp: 3.884 ± 0.075	4.996ValGlu: 4.996 ± 0.091	3.042ValPhe: 3.042 ± 0.06	4.695ValGly: 4.695 ± 0.08	0.99ValHis: 0.99 ± 0.04	6.624ValIle: 6.624 ± 0.098	4.915ValLys: 4.915 ± 0.081	6.578ValLeu: 6.578 ± 0.093	1.676ValMet: 1.676 ± 0.047	3.718ValAsn: 3.718 ± 0.071	2.163ValPro: 2.163 ± 0.054	1.732ValGln: 1.732 ± 0.044	2.359ValArg: 2.359 ± 0.063	4.337ValSer: 4.337 ± 0.086	3.73ValThr: 3.73 ± 0.087	5.19ValVal: 5.19 ± 0.088	0.362ValTrp: 0.362 ± 0.023	2.337ValTyr: 2.337 ± 0.053	0.0ValXaa: 0.0 ± 0.0
Trp	0.407TrpAla: 0.407 ± 0.022	0.073TrpCys: 0.073 ± 0.01	0.376TrpAsp: 0.376 ± 0.021	0.463TrpGlu: 0.463 ± 0.028	0.331TrpPhe: 0.331 ± 0.019	0.473TrpGly: 0.473 ± 0.024	0.114TrpHis: 0.114 ± 0.013	0.603TrpIle: 0.603 ± 0.026	0.456TrpLys: 0.456 ± 0.022	0.662TrpLeu: 0.662 ± 0.028	0.189TrpMet: 0.189 ± 0.016	0.402TrpAsn: 0.402 ± 0.024	0.168TrpPro: 0.168 ± 0.014	0.205TrpGln: 0.205 ± 0.013	0.302TrpArg: 0.302 ± 0.017	0.412TrpSer: 0.412 ± 0.024	0.328TrpThr: 0.328 ± 0.02	0.433TrpVal: 0.433 ± 0.028	0.078TrpTrp: 0.078 ± 0.01	0.266TrpTyr: 0.266 ± 0.018	0.0TrpXaa: 0.0 ± 0.0
Tyr	1.885TyrAla: 1.885 ± 0.046	0.454TyrCys: 0.454 ± 0.022	2.065TyrAsp: 2.065 ± 0.057	2.702TyrGlu: 2.702 ± 0.065	1.945TyrPhe: 1.945 ± 0.048	2.526TyrGly: 2.526 ± 0.055	0.567TyrHis: 0.567 ± 0.026	3.816TyrIle: 3.816 ± 0.071	2.892TyrLys: 2.892 ± 0.068	3.624TyrLeu: 3.624 ± 0.074	0.943TyrMet: 0.943 ± 0.036	2.353TyrAsn: 2.353 ± 0.056	1.33TyrPro: 1.33 ± 0.042	0.882TyrGln: 0.882 ± 0.036	1.65TyrArg: 1.65 ± 0.048	2.636TyrSer: 2.636 ± 0.061	1.983TyrThr: 1.983 ± 0.048	2.13TyrVal: 2.13 ± 0.049	0.289TyrTrp: 0.289 ± 0.022	1.72TyrTyr: 1.72 ± 0.051	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2966 proteins (857452 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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