Amino acid dipepetide frequency for Aspergillus nomiae NRRL 13137

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	8.275AlaAla: 8.275 ± 0.054	1.132AlaCys: 1.132 ± 0.013	4.092AlaAsp: 4.092 ± 0.027	4.856AlaGlu: 4.856 ± 0.034	3.208AlaPhe: 3.208 ± 0.024	5.621AlaGly: 5.621 ± 0.037	1.787AlaHis: 1.787 ± 0.021	4.418AlaIle: 4.418 ± 0.031	3.729AlaLys: 3.729 ± 0.027	7.872AlaLeu: 7.872 ± 0.043	1.968AlaMet: 1.968 ± 0.018	2.888AlaAsn: 2.888 ± 0.022	4.403AlaPro: 4.403 ± 0.04	3.31AlaGln: 3.31 ± 0.026	4.718AlaArg: 4.718 ± 0.031	6.998AlaSer: 6.998 ± 0.041	5.126AlaThr: 5.126 ± 0.032	5.472AlaVal: 5.472 ± 0.032	1.188AlaTrp: 1.188 ± 0.018	2.28AlaTyr: 2.28 ± 0.021	0.0AlaXaa: 0.0 ± 0.0
Cys	1.015CysAla: 1.015 ± 0.014	0.252CysCys: 0.252 ± 0.007	0.707CysAsp: 0.707 ± 0.011	0.625CysGlu: 0.625 ± 0.011	0.568CysPhe: 0.568 ± 0.011	0.945CysGly: 0.945 ± 0.014	0.36CysHis: 0.36 ± 0.009	0.787CysIle: 0.787 ± 0.012	0.497CysLys: 0.497 ± 0.01	1.407CysLeu: 1.407 ± 0.017	0.29CysMet: 0.29 ± 0.008	0.464CysAsn: 0.464 ± 0.01	0.68CysPro: 0.68 ± 0.013	0.487CysGln: 0.487 ± 0.008	0.818CysArg: 0.818 ± 0.013	0.998CysSer: 0.998 ± 0.013	0.743CysThr: 0.743 ± 0.012	0.854CysVal: 0.854 ± 0.014	0.214CysTrp: 0.214 ± 0.006	0.392CysTyr: 0.392 ± 0.009	0.0CysXaa: 0.0 ± 0.0
Asp	4.465AspAla: 4.465 ± 0.027	0.639AspCys: 0.639 ± 0.011	3.79AspAsp: 3.79 ± 0.037	4.107AspGlu: 4.107 ± 0.037	2.147AspPhe: 2.147 ± 0.02	3.927AspGly: 3.927 ± 0.031	1.291AspHis: 1.291 ± 0.013	3.228AspIle: 3.228 ± 0.023	2.24AspLys: 2.24 ± 0.024	5.173AspLeu: 5.173 ± 0.033	1.259AspMet: 1.259 ± 0.016	1.907AspAsn: 1.907 ± 0.019	3.36AspPro: 3.36 ± 0.025	1.944AspGln: 1.944 ± 0.02	3.077AspArg: 3.077 ± 0.025	4.121AspSer: 4.121 ± 0.031	3.074AspThr: 3.074 ± 0.022	3.657AspVal: 3.657 ± 0.026	0.896AspTrp: 0.896 ± 0.013	1.681AspTyr: 1.681 ± 0.018	0.0AspXaa: 0.0 ± 0.0
Glu	5.109GluAla: 5.109 ± 0.034	0.67GluCys: 0.67 ± 0.011	3.909GluAsp: 3.909 ± 0.036	5.158GluGlu: 5.158 ± 0.047	1.95GluPhe: 1.95 ± 0.018	3.593GluGly: 3.593 ± 0.029	1.411GluHis: 1.411 ± 0.016	3.091GluIle: 3.091 ± 0.023	3.529GluLys: 3.529 ± 0.029	5.224GluLeu: 5.224 ± 0.033	1.397GluMet: 1.397 ± 0.018	2.35GluAsn: 2.35 ± 0.024	2.767GluPro: 2.767 ± 0.04	2.527GluGln: 2.527 ± 0.025	3.79GluArg: 3.79 ± 0.03	4.352GluSer: 4.352 ± 0.034	3.523GluThr: 3.523 ± 0.027	3.53GluVal: 3.53 ± 0.024	0.898GluTrp: 0.898 ± 0.012	1.752GluTyr: 1.752 ± 0.018	0.0GluXaa: 0.0 ± 0.0
Phe	3.059PheAla: 3.059 ± 0.02	0.6PheCys: 0.6 ± 0.012	2.271PheAsp: 2.271 ± 0.021	2.084PheGlu: 2.084 ± 0.024	1.685PhePhe: 1.685 ± 0.021	2.858PheGly: 2.858 ± 0.024	0.987PheHis: 0.987 ± 0.015	1.952PheIle: 1.952 ± 0.019	1.446PheLys: 1.446 ± 0.017	3.753PheLeu: 3.753 ± 0.031	0.809PheMet: 0.809 ± 0.011	1.468PheAsn: 1.468 ± 0.015	2.046PhePro: 2.046 ± 0.021	1.473PheGln: 1.473 ± 0.017	2.016PheArg: 2.016 ± 0.023	3.065PheSer: 3.065 ± 0.024	2.244PheThr: 2.244 ± 0.02	2.464PheVal: 2.464 ± 0.022	0.684PheTrp: 0.684 ± 0.012	1.216PheTyr: 1.216 ± 0.017	0.0PheXaa: 0.0 ± 0.0
Gly	5.163GlyAla: 5.163 ± 0.037	0.943GlyCys: 0.943 ± 0.014	3.578GlyAsp: 3.578 ± 0.03	3.531GlyGlu: 3.531 ± 0.028	2.866GlyPhe: 2.866 ± 0.024	5.272GlyGly: 5.272 ± 0.041	1.694GlyHis: 1.694 ± 0.017	3.717GlyIle: 3.717 ± 0.027	3.272GlyLys: 3.272 ± 0.03	6.339GlyLeu: 6.339 ± 0.033	1.544GlyMet: 1.544 ± 0.018	2.549GlyAsn: 2.549 ± 0.022	3.295GlyPro: 3.295 ± 0.025	2.599GlyGln: 2.599 ± 0.022	3.938GlyArg: 3.938 ± 0.028	5.648GlySer: 5.648 ± 0.039	3.985GlyThr: 3.985 ± 0.026	4.548GlyVal: 4.548 ± 0.031	1.21GlyTrp: 1.21 ± 0.013	2.247GlyTyr: 2.247 ± 0.02	0.0GlyXaa: 0.0 ± 0.0
His	1.846HisAla: 1.846 ± 0.018	0.362HisCys: 0.362 ± 0.007	1.355HisAsp: 1.355 ± 0.017	1.347HisGlu: 1.347 ± 0.016	0.951HisPhe: 0.951 ± 0.013	1.75HisGly: 1.75 ± 0.018	0.862HisHis: 0.862 ± 0.014	1.322HisIle: 1.322 ± 0.017	0.854HisLys: 0.854 ± 0.013	2.337HisLeu: 2.337 ± 0.02	0.518HisMet: 0.518 ± 0.009	0.858HisAsn: 0.858 ± 0.013	1.716HisPro: 1.716 ± 0.019	0.967HisGln: 0.967 ± 0.015	1.598HisArg: 1.598 ± 0.017	1.922HisSer: 1.922 ± 0.022	1.318HisThr: 1.318 ± 0.017	1.461HisVal: 1.461 ± 0.016	0.379HisTrp: 0.379 ± 0.008	0.737HisTyr: 0.737 ± 0.011	0.0HisXaa: 0.0 ± 0.0
Ile	4.338IleAla: 4.338 ± 0.033	0.819IleCys: 0.819 ± 0.015	2.903IleAsp: 2.903 ± 0.023	2.855IleGlu: 2.855 ± 0.022	2.122IlePhe: 2.122 ± 0.024	3.402IleGly: 3.402 ± 0.027	1.307IleHis: 1.307 ± 0.015	2.662IleIle: 2.662 ± 0.027	2.045IleLys: 2.045 ± 0.019	4.909IleLeu: 4.909 ± 0.036	1.078IleMet: 1.078 ± 0.015	1.854IleAsn: 1.854 ± 0.021	3.253IlePro: 3.253 ± 0.023	2.032IleGln: 2.032 ± 0.021	2.852IleArg: 2.852 ± 0.021	4.058IleSer: 4.058 ± 0.027	2.918IleThr: 2.918 ± 0.026	3.393IleVal: 3.393 ± 0.029	0.761IleTrp: 0.761 ± 0.011	1.568IleTyr: 1.568 ± 0.018	0.0IleXaa: 0.0 ± 0.0
Lys	3.972LysAla: 3.972 ± 0.026	0.537LysCys: 0.537 ± 0.01	2.693LysAsp: 2.693 ± 0.023	3.239LysGlu: 3.239 ± 0.03	1.381LysPhe: 1.381 ± 0.016	2.881LysGly: 2.881 ± 0.025	1.076LysHis: 1.076 ± 0.014	2.141LysIle: 2.141 ± 0.019	2.851LysLys: 2.851 ± 0.038	3.955LysLeu: 3.955 ± 0.027	0.923LysMet: 0.923 ± 0.012	1.649LysAsn: 1.649 ± 0.019	2.542LysPro: 2.542 ± 0.025	1.811LysGln: 1.811 ± 0.02	3.139LysArg: 3.139 ± 0.029	3.314LysSer: 3.314 ± 0.025	2.614LysThr: 2.614 ± 0.022	2.772LysVal: 2.772 ± 0.024	0.657LysTrp: 0.657 ± 0.011	1.385LysTyr: 1.385 ± 0.014	0.0LysXaa: 0.0 ± 0.0
Leu	7.91LeuAla: 7.91 ± 0.039	1.32LeuCys: 1.32 ± 0.017	5.251LeuAsp: 5.251 ± 0.035	5.588LeuGlu: 5.588 ± 0.035	3.556LeuPhe: 3.556 ± 0.029	6.186LeuGly: 6.186 ± 0.036	2.366LeuHis: 2.366 ± 0.021	4.221LeuIle: 4.221 ± 0.029	4.087LeuLys: 4.087 ± 0.03	8.968LeuLeu: 8.968 ± 0.048	1.85LeuMet: 1.85 ± 0.018	3.313LeuAsn: 3.313 ± 0.024	5.594LeuPro: 5.594 ± 0.032	4.002LeuGln: 4.002 ± 0.029	5.867LeuArg: 5.867 ± 0.035	7.79LeuSer: 7.79 ± 0.048	4.972LeuThr: 4.972 ± 0.029	5.721LeuVal: 5.721 ± 0.034	1.263LeuTrp: 1.263 ± 0.015	2.598LeuTyr: 2.598 ± 0.025	0.0LeuXaa: 0.0 ± 0.0
Met	2.166MetAla: 2.166 ± 0.022	0.266MetCys: 0.266 ± 0.007	1.238MetAsp: 1.238 ± 0.015	1.298MetGlu: 1.298 ± 0.013	0.751MetPhe: 0.751 ± 0.012	1.48MetGly: 1.48 ± 0.017	0.483MetHis: 0.483 ± 0.009	1.044MetIle: 1.044 ± 0.014	0.981MetLys: 0.981 ± 0.012	1.92MetLeu: 1.92 ± 0.019	0.554MetMet: 0.554 ± 0.01	0.81MetAsn: 0.81 ± 0.014	1.175MetPro: 1.175 ± 0.014	0.862MetGln: 0.862 ± 0.011	1.24MetArg: 1.24 ± 0.014	1.858MetSer: 1.858 ± 0.017	1.304MetThr: 1.304 ± 0.016	1.393MetVal: 1.393 ± 0.016	0.265MetTrp: 0.265 ± 0.006	0.55MetTyr: 0.55 ± 0.009	0.0MetXaa: 0.0 ± 0.0
Asn	3.101AsnAla: 3.101 ± 0.023	0.485AsnCys: 0.485 ± 0.009	1.962AsnAsp: 1.962 ± 0.019	2.044AsnGlu: 2.044 ± 0.019	1.355AsnPhe: 1.355 ± 0.016	2.93AsnGly: 2.93 ± 0.025	0.87AsnHis: 0.87 ± 0.013	2.146AsnIle: 2.146 ± 0.019	1.483AsnLys: 1.483 ± 0.017	3.281AsnLeu: 3.281 ± 0.026	0.863AsnMet: 0.863 ± 0.011	1.455AsnAsn: 1.455 ± 0.017	2.49AsnPro: 2.49 ± 0.019	1.337AsnGln: 1.337 ± 0.016	1.958AsnArg: 1.958 ± 0.018	2.717AsnSer: 2.717 ± 0.024	2.228AsnThr: 2.228 ± 0.018	2.393AsnVal: 2.393 ± 0.021	0.587AsnTrp: 0.587 ± 0.01	1.11AsnTyr: 1.11 ± 0.015	0.0AsnXaa: 0.0 ± 0.0
Pro	4.752ProAla: 4.752 ± 0.04	0.573ProCys: 0.573 ± 0.009	3.215ProAsp: 3.215 ± 0.025	3.898ProGlu: 3.898 ± 0.038	2.172ProPhe: 2.172 ± 0.021	3.883ProGly: 3.883 ± 0.031	1.32ProHis: 1.32 ± 0.016	2.559ProIle: 2.559 ± 0.021	2.53ProLys: 2.53 ± 0.027	4.823ProLeu: 4.823 ± 0.032	1.059ProMet: 1.059 ± 0.016	2.176ProAsn: 2.176 ± 0.023	4.449ProPro: 4.449 ± 0.057	2.408ProGln: 2.408 ± 0.025	3.319ProArg: 3.319 ± 0.027	5.927ProSer: 5.927 ± 0.042	3.892ProThr: 3.892 ± 0.034	3.684ProVal: 3.684 ± 0.029	0.802ProTrp: 0.802 ± 0.013	1.555ProTyr: 1.555 ± 0.017	0.0ProXaa: 0.0 ± 0.0
Gln	3.352GlnAla: 3.352 ± 0.028	0.482GlnCys: 0.482 ± 0.01	2.07GlnAsp: 2.07 ± 0.018	2.481GlnGlu: 2.481 ± 0.021	1.341GlnPhe: 1.341 ± 0.014	2.492GlnGly: 2.492 ± 0.018	1.047GlnHis: 1.047 ± 0.017	1.949GlnIle: 1.949 ± 0.017	1.982GlnLys: 1.982 ± 0.018	3.593GlnLeu: 3.593 ± 0.029	0.885GlnMet: 0.885 ± 0.013	1.591GlnAsn: 1.591 ± 0.017	2.486GlnPro: 2.486 ± 0.027	2.242GlnGln: 2.242 ± 0.039	2.63GlnArg: 2.63 ± 0.022	3.238GlnSer: 3.238 ± 0.024	2.369GlnThr: 2.369 ± 0.019	2.247GlnVal: 2.247 ± 0.022	0.617GlnTrp: 0.617 ± 0.011	1.23GlnTyr: 1.23 ± 0.014	0.0GlnXaa: 0.0 ± 0.0
Arg	4.501ArgAla: 4.501 ± 0.027	0.743ArgCys: 0.743 ± 0.013	3.269ArgAsp: 3.269 ± 0.027	3.706ArgGlu: 3.706 ± 0.031	2.219ArgPhe: 2.219 ± 0.02	3.557ArgGly: 3.557 ± 0.028	1.556ArgHis: 1.556 ± 0.018	2.929ArgIle: 2.929 ± 0.022	3.227ArgLys: 3.227 ± 0.027	5.687ArgLeu: 5.687 ± 0.035	1.289ArgMet: 1.289 ± 0.017	2.238ArgAsn: 2.238 ± 0.019	3.369ArgPro: 3.369 ± 0.032	2.583ArgGln: 2.583 ± 0.024	4.872ArgArg: 4.872 ± 0.038	4.745ArgSer: 4.745 ± 0.035	3.234ArgThr: 3.234 ± 0.026	3.478ArgVal: 3.478 ± 0.024	0.99ArgTrp: 0.99 ± 0.013	1.771ArgTyr: 1.771 ± 0.019	0.0ArgXaa: 0.0 ± 0.0
Ser	6.493SerAla: 6.493 ± 0.034	0.953SerCys: 0.953 ± 0.013	4.298SerAsp: 4.298 ± 0.031	4.237SerGlu: 4.237 ± 0.028	3.178SerPhe: 3.178 ± 0.026	5.532SerGly: 5.532 ± 0.036	2.031SerHis: 2.031 ± 0.022	4.177SerIle: 4.177 ± 0.028	3.586SerLys: 3.586 ± 0.026	7.622SerLeu: 7.622 ± 0.04	1.719SerMet: 1.719 ± 0.019	2.983SerAsn: 2.983 ± 0.026	5.286SerPro: 5.286 ± 0.039	3.384SerGln: 3.384 ± 0.026	4.9SerArg: 4.9 ± 0.038	8.574SerSer: 8.574 ± 0.059	5.539SerThr: 5.539 ± 0.036	4.811SerVal: 4.811 ± 0.031	1.199SerTrp: 1.199 ± 0.015	2.171SerTyr: 2.171 ± 0.022	0.0SerXaa: 0.0 ± 0.0
Thr	5.133ThrAla: 5.133 ± 0.03	0.786ThrCys: 0.786 ± 0.011	2.947ThrAsp: 2.947 ± 0.026	3.22ThrGlu: 3.22 ± 0.026	2.291ThrPhe: 2.291 ± 0.023	4.29ThrGly: 4.29 ± 0.029	1.332ThrHis: 1.332 ± 0.016	3.173ThrIle: 3.173 ± 0.024	2.48ThrLys: 2.48 ± 0.022	5.376ThrLeu: 5.376 ± 0.033	1.253ThrMet: 1.253 ± 0.016	2.091ThrAsn: 2.091 ± 0.019	4.159ThrPro: 4.159 ± 0.034	2.094ThrGln: 2.094 ± 0.018	3.038ThrArg: 3.038 ± 0.022	5.19ThrSer: 5.19 ± 0.033	4.125ThrThr: 4.125 ± 0.039	3.975ThrVal: 3.975 ± 0.033	0.898ThrTrp: 0.898 ± 0.013	1.697ThrTyr: 1.697 ± 0.018	0.0ThrXaa: 0.0 ± 0.0
Val	5.275ValAla: 5.275 ± 0.035	0.892ValCys: 0.892 ± 0.013	3.815ValAsp: 3.815 ± 0.028	3.789ValGlu: 3.789 ± 0.031	2.589ValPhe: 2.589 ± 0.023	4.159ValGly: 4.159 ± 0.031	1.498ValHis: 1.498 ± 0.016	3.194ValIle: 3.194 ± 0.025	2.796ValLys: 2.796 ± 0.024	5.849ValLeu: 5.849 ± 0.033	1.353ValMet: 1.353 ± 0.016	2.312ValAsn: 2.312 ± 0.023	3.683ValPro: 3.683 ± 0.027	2.49ValGln: 2.49 ± 0.02	3.474ValArg: 3.474 ± 0.025	4.919ValSer: 4.919 ± 0.032	3.652ValThr: 3.652 ± 0.031	4.404ValVal: 4.404 ± 0.03	0.908ValTrp: 0.908 ± 0.013	1.893ValTyr: 1.893 ± 0.019	0.0ValXaa: 0.0 ± 0.0
Trp	1.175TrpAla: 1.175 ± 0.016	0.209TrpCys: 0.209 ± 0.006	0.927TrpAsp: 0.927 ± 0.014	0.876TrpGlu: 0.876 ± 0.012	0.578TrpPhe: 0.578 ± 0.01	0.98TrpGly: 0.98 ± 0.012	0.377TrpHis: 0.377 ± 0.009	0.827TrpIle: 0.827 ± 0.013	0.833TrpLys: 0.833 ± 0.012	1.449TrpLeu: 1.449 ± 0.014	0.382TrpMet: 0.382 ± 0.008	0.666TrpAsn: 0.666 ± 0.012	0.628TrpPro: 0.628 ± 0.012	0.585TrpGln: 0.585 ± 0.01	0.979TrpArg: 0.979 ± 0.012	1.075TrpSer: 1.075 ± 0.015	0.953TrpThr: 0.953 ± 0.015	0.94TrpVal: 0.94 ± 0.013	0.293TrpTrp: 0.293 ± 0.007	0.462TrpTyr: 0.462 ± 0.01	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.239TyrAla: 2.239 ± 0.022	0.441TyrCys: 0.441 ± 0.011	1.694TyrAsp: 1.694 ± 0.016	1.591TyrGlu: 1.591 ± 0.018	1.273TyrPhe: 1.273 ± 0.017	2.198TyrGly: 2.198 ± 0.025	0.803TyrHis: 0.803 ± 0.014	1.589TyrIle: 1.589 ± 0.019	1.086TyrLys: 1.086 ± 0.015	2.884TyrLeu: 2.884 ± 0.021	0.645TyrMet: 0.645 ± 0.009	1.173TyrAsn: 1.173 ± 0.016	1.617TyrPro: 1.617 ± 0.016	1.189TyrGln: 1.189 ± 0.015	1.739TyrArg: 1.739 ± 0.018	2.166TyrSer: 2.166 ± 0.02	1.737TyrThr: 1.737 ± 0.019	1.747TyrVal: 1.747 ± 0.017	0.486TyrTrp: 0.486 ± 0.009	1.009TyrTyr: 1.009 ± 0.013	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 11914 proteins (5973996 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

---