Amino acid dipepetide frequency for Massilia armeniaca

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	19.989AlaAla: 19.989 ± 0.2	1.275AlaCys: 1.275 ± 0.028	6.947AlaAsp: 6.947 ± 0.065	6.463AlaGlu: 6.463 ± 0.087	3.891AlaPhe: 3.891 ± 0.05	11.566AlaGly: 11.566 ± 0.115	2.567AlaHis: 2.567 ± 0.039	5.536AlaIle: 5.536 ± 0.061	3.844AlaLys: 3.844 ± 0.07	15.143AlaLeu: 15.143 ± 0.163	3.176AlaMet: 3.176 ± 0.04	3.316AlaAsn: 3.316 ± 0.052	6.899AlaPro: 6.899 ± 0.09	5.83AlaGln: 5.83 ± 0.069	9.171AlaArg: 9.171 ± 0.107	6.6AlaSer: 6.6 ± 0.073	6.768AlaThr: 6.768 ± 0.08	9.005AlaVal: 9.005 ± 0.085	1.85AlaTrp: 1.85 ± 0.038	2.772AlaTyr: 2.772 ± 0.041	0.0AlaXaa: 0.0 ± 0.0
Cys	1.251CysAla: 1.251 ± 0.027	0.129CysCys: 0.129 ± 0.009	0.52CysAsp: 0.52 ± 0.017	0.416CysGlu: 0.416 ± 0.016	0.267CysPhe: 0.267 ± 0.012	0.937CysGly: 0.937 ± 0.026	0.262CysHis: 0.262 ± 0.014	0.366CysIle: 0.366 ± 0.015	0.208CysLys: 0.208 ± 0.012	0.795CysLeu: 0.795 ± 0.023	0.192CysMet: 0.192 ± 0.01	0.238CysAsn: 0.238 ± 0.013	0.44CysPro: 0.44 ± 0.018	0.255CysGln: 0.255 ± 0.011	0.615CysArg: 0.615 ± 0.021	0.447CysSer: 0.447 ± 0.018	0.486CysThr: 0.486 ± 0.018	0.645CysVal: 0.645 ± 0.022	0.14CysTrp: 0.14 ± 0.009	0.23CysTyr: 0.23 ± 0.012	0.0CysXaa: 0.0 ± 0.0
Asp	7.115AspAla: 7.115 ± 0.073	0.479AspCys: 0.479 ± 0.018	3.045AspAsp: 3.045 ± 0.045	3.218AspGlu: 3.218 ± 0.051	2.076AspPhe: 2.076 ± 0.034	5.373AspGly: 5.373 ± 0.071	1.023AspHis: 1.023 ± 0.027	2.6AspIle: 2.6 ± 0.042	1.988AspLys: 1.988 ± 0.04	5.069AspLeu: 5.069 ± 0.053	1.215AspMet: 1.215 ± 0.027	1.582AspAsn: 1.582 ± 0.033	2.961AspPro: 2.961 ± 0.045	1.747AspGln: 1.747 ± 0.034	3.1AspArg: 3.1 ± 0.049	2.553AspSer: 2.553 ± 0.036	2.875AspThr: 2.875 ± 0.053	4.217AspVal: 4.217 ± 0.046	0.945AspTrp: 0.945 ± 0.024	1.642AspTyr: 1.642 ± 0.038	0.0AspXaa: 0.0 ± 0.0
Glu	6.212GluAla: 6.212 ± 0.065	0.365GluCys: 0.365 ± 0.014	2.117GluAsp: 2.117 ± 0.034	2.702GluGlu: 2.702 ± 0.049	1.732GluPhe: 1.732 ± 0.03	3.389GluGly: 3.389 ± 0.043	1.358GluHis: 1.358 ± 0.03	2.433GluIle: 2.433 ± 0.047	1.857GluLys: 1.857 ± 0.039	5.945GluLeu: 5.945 ± 0.076	1.206GluMet: 1.206 ± 0.028	1.347GluAsn: 1.347 ± 0.027	2.314GluPro: 2.314 ± 0.04	2.809GluGln: 2.809 ± 0.044	4.637GluArg: 4.637 ± 0.06	2.127GluSer: 2.127 ± 0.037	2.639GluThr: 2.639 ± 0.04	3.491GluVal: 3.491 ± 0.053	0.719GluTrp: 0.719 ± 0.02	1.201GluTyr: 1.201 ± 0.029	0.0GluXaa: 0.0 ± 0.0
Phe	4.26PheAla: 4.26 ± 0.053	0.357PheCys: 0.357 ± 0.015	2.58PheAsp: 2.58 ± 0.042	1.809PheGlu: 1.809 ± 0.036	1.228PhePhe: 1.228 ± 0.034	3.27PheGly: 3.27 ± 0.048	0.748PheHis: 0.748 ± 0.02	1.468PheIle: 1.468 ± 0.032	1.088PheLys: 1.088 ± 0.028	2.898PheLeu: 2.898 ± 0.045	0.745PheMet: 0.745 ± 0.021	1.197PheAsn: 1.197 ± 0.025	1.38PhePro: 1.38 ± 0.028	1.052PheGln: 1.052 ± 0.028	1.89PheArg: 1.89 ± 0.029	1.974PheSer: 1.974 ± 0.036	2.053PheThr: 2.053 ± 0.036	2.645PheVal: 2.645 ± 0.042	0.465PheTrp: 0.465 ± 0.018	0.994PheTyr: 0.994 ± 0.025	0.0PheXaa: 0.0 ± 0.0
Gly	9.905GlyAla: 9.905 ± 0.099	0.824GlyCys: 0.824 ± 0.024	4.183GlyAsp: 4.183 ± 0.062	4.062GlyGlu: 4.062 ± 0.052	3.121GlyPhe: 3.121 ± 0.043	7.08GlyGly: 7.08 ± 0.093	1.92GlyHis: 1.92 ± 0.042	4.165GlyIle: 4.165 ± 0.053	3.625GlyLys: 3.625 ± 0.056	7.993GlyLeu: 7.993 ± 0.083	2.318GlyMet: 2.318 ± 0.035	2.666GlyAsn: 2.666 ± 0.061	3.002GlyPro: 3.002 ± 0.048	3.238GlyGln: 3.238 ± 0.047	5.514GlyArg: 5.514 ± 0.059	4.706GlySer: 4.706 ± 0.063	5.144GlyThr: 5.144 ± 0.076	6.155GlyVal: 6.155 ± 0.066	1.43GlyTrp: 1.43 ± 0.032	2.478GlyTyr: 2.478 ± 0.039	0.0GlyXaa: 0.0 ± 0.0
His	2.855HisAla: 2.855 ± 0.049	0.261HisCys: 0.261 ± 0.012	1.314HisAsp: 1.314 ± 0.026	1.159HisGlu: 1.159 ± 0.029	0.872HisPhe: 0.872 ± 0.023	2.277HisGly: 2.277 ± 0.04	0.635HisHis: 0.635 ± 0.024	0.905HisIle: 0.905 ± 0.024	0.609HisLys: 0.609 ± 0.019	2.13HisLeu: 2.13 ± 0.039	0.5HisMet: 0.5 ± 0.018	0.552HisAsn: 0.552 ± 0.019	1.319HisPro: 1.319 ± 0.029	0.732HisGln: 0.732 ± 0.018	1.403HisArg: 1.403 ± 0.028	1.002HisSer: 1.002 ± 0.023	1.049HisThr: 1.049 ± 0.022	1.661HisVal: 1.661 ± 0.035	0.375HisTrp: 0.375 ± 0.013	0.675HisTyr: 0.675 ± 0.019	0.0HisXaa: 0.0 ± 0.0
Ile	6.235IleAla: 6.235 ± 0.07	0.367IleCys: 0.367 ± 0.013	3.243IleAsp: 3.243 ± 0.044	2.86IleGlu: 2.86 ± 0.042	1.212IlePhe: 1.212 ± 0.027	4.288IleGly: 4.288 ± 0.054	0.874IleHis: 0.874 ± 0.023	1.514IleIle: 1.514 ± 0.038	1.429IleLys: 1.429 ± 0.03	3.44IleLeu: 3.44 ± 0.053	0.775IleMet: 0.775 ± 0.022	1.399IleAsn: 1.399 ± 0.031	1.944IlePro: 1.944 ± 0.031	1.042IleGln: 1.042 ± 0.025	2.647IleArg: 2.647 ± 0.041	2.247IleSer: 2.247 ± 0.037	2.38IleThr: 2.38 ± 0.04	3.996IleVal: 3.996 ± 0.055	0.442IleTrp: 0.442 ± 0.018	0.957IleTyr: 0.957 ± 0.026	0.0IleXaa: 0.0 ± 0.0
Lys	3.959LysAla: 3.959 ± 0.064	0.143LysCys: 0.143 ± 0.009	1.67LysAsp: 1.67 ± 0.036	1.626LysGlu: 1.626 ± 0.033	1.029LysPhe: 1.029 ± 0.023	2.365LysGly: 2.365 ± 0.04	0.686LysHis: 0.686 ± 0.024	1.481LysIle: 1.481 ± 0.036	1.432LysLys: 1.432 ± 0.04	3.692LysLeu: 3.692 ± 0.05	0.869LysMet: 0.869 ± 0.027	1.115LysAsn: 1.115 ± 0.034	2.043LysPro: 2.043 ± 0.038	1.316LysGln: 1.316 ± 0.029	2.02LysArg: 2.02 ± 0.037	1.681LysSer: 1.681 ± 0.035	1.861LysThr: 1.861 ± 0.043	2.569LysVal: 2.569 ± 0.047	0.371LysTrp: 0.371 ± 0.016	0.784LysTyr: 0.784 ± 0.024	0.0LysXaa: 0.0 ± 0.0
Leu	15.941LeuAla: 15.941 ± 0.153	1.037LeuCys: 1.037 ± 0.027	5.929LeuAsp: 5.929 ± 0.06	5.007LeuGlu: 5.007 ± 0.071	3.386LeuPhe: 3.386 ± 0.047	7.985LeuGly: 7.985 ± 0.073	2.36LeuHis: 2.36 ± 0.043	3.872LeuIle: 3.872 ± 0.057	3.389LeuLys: 3.389 ± 0.043	11.462LeuLeu: 11.462 ± 0.132	2.164LeuMet: 2.164 ± 0.039	2.786LeuAsn: 2.786 ± 0.04	6.147LeuPro: 6.147 ± 0.068	3.972LeuGln: 3.972 ± 0.054	7.921LeuArg: 7.921 ± 0.089	5.417LeuSer: 5.417 ± 0.065	5.703LeuThr: 5.703 ± 0.079	7.5LeuVal: 7.5 ± 0.067	1.191LeuTrp: 1.191 ± 0.032	2.326LeuTyr: 2.326 ± 0.036	0.0LeuXaa: 0.0 ± 0.0
Met	2.839MetAla: 2.839 ± 0.044	0.154MetCys: 0.154 ± 0.01	1.115MetAsp: 1.115 ± 0.025	1.043MetGlu: 1.043 ± 0.027	0.671MetPhe: 0.671 ± 0.021	1.615MetGly: 1.615 ± 0.031	0.522MetHis: 0.522 ± 0.017	0.928MetIle: 0.928 ± 0.022	0.987MetLys: 0.987 ± 0.027	2.595MetLeu: 2.595 ± 0.044	0.608MetMet: 0.608 ± 0.02	0.855MetAsn: 0.855 ± 0.02	1.361MetPro: 1.361 ± 0.028	1.088MetGln: 1.088 ± 0.026	1.619MetArg: 1.619 ± 0.032	1.376MetSer: 1.376 ± 0.03	1.613MetThr: 1.613 ± 0.03	1.551MetVal: 1.551 ± 0.03	0.196MetTrp: 0.196 ± 0.01	0.442MetTyr: 0.442 ± 0.016	0.0MetXaa: 0.0 ± 0.0
Asn	3.541AsnAla: 3.541 ± 0.05	0.267AsnCys: 0.267 ± 0.013	1.581AsnAsp: 1.581 ± 0.047	1.282AsnGlu: 1.282 ± 0.028	1.0AsnPhe: 1.0 ± 0.025	2.784AsnGly: 2.784 ± 0.048	0.568AsnHis: 0.568 ± 0.017	1.326AsnIle: 1.326 ± 0.032	0.903AsnLys: 0.903 ± 0.027	2.874AsnLeu: 2.874 ± 0.045	0.644AsnMet: 0.644 ± 0.02	0.967AsnAsn: 0.967 ± 0.03	1.809AsnPro: 1.809 ± 0.034	0.969AsnGln: 0.969 ± 0.027	1.814AsnArg: 1.814 ± 0.035	1.339AsnSer: 1.339 ± 0.03	1.582AsnThr: 1.582 ± 0.032	2.394AsnVal: 2.394 ± 0.044	0.414AsnTrp: 0.414 ± 0.017	0.885AsnTyr: 0.885 ± 0.024	0.0AsnXaa: 0.0 ± 0.0
Pro	7.95ProAla: 7.95 ± 0.091	0.39ProCys: 0.39 ± 0.015	3.318ProAsp: 3.318 ± 0.047	3.056ProGlu: 3.056 ± 0.042	1.758ProPhe: 1.758 ± 0.033	4.658ProGly: 4.658 ± 0.059	1.136ProHis: 1.136 ± 0.027	1.796ProIle: 1.796 ± 0.032	1.425ProLys: 1.425 ± 0.033	5.228ProLeu: 5.228 ± 0.062	1.067ProMet: 1.067 ± 0.025	1.39ProAsn: 1.39 ± 0.027	2.703ProPro: 2.703 ± 0.051	2.017ProGln: 2.017 ± 0.036	2.892ProArg: 2.892 ± 0.05	2.398ProSer: 2.398 ± 0.035	2.498ProThr: 2.498 ± 0.042	4.284ProVal: 4.284 ± 0.051	0.665ProTrp: 0.665 ± 0.022	1.225ProTyr: 1.225 ± 0.025	0.0ProXaa: 0.0 ± 0.0
Gln	5.636GlnAla: 5.636 ± 0.07	0.292GlnCys: 0.292 ± 0.013	1.692GlnAsp: 1.692 ± 0.034	1.706GlnGlu: 1.706 ± 0.036	1.366GlnPhe: 1.366 ± 0.028	3.023GlnGly: 3.023 ± 0.045	0.985GlnHis: 0.985 ± 0.023	1.612GlnIle: 1.612 ± 0.035	1.164GlnLys: 1.164 ± 0.029	4.511GlnLeu: 4.511 ± 0.058	0.973GlnMet: 0.973 ± 0.023	0.977GlnAsn: 0.977 ± 0.024	2.275GlnPro: 2.275 ± 0.043	2.085GlnGln: 2.085 ± 0.038	3.277GlnArg: 3.277 ± 0.047	1.761GlnSer: 1.761 ± 0.036	1.763GlnThr: 1.763 ± 0.035	3.001GlnVal: 3.001 ± 0.05	0.572GlnTrp: 0.572 ± 0.017	1.007GlnTyr: 1.007 ± 0.027	0.0GlnXaa: 0.0 ± 0.0
Arg	8.137ArgAla: 8.137 ± 0.079	0.586ArgCys: 0.586 ± 0.018	3.813ArgAsp: 3.813 ± 0.06	3.751ArgGlu: 3.751 ± 0.049	2.649ArgPhe: 2.649 ± 0.036	4.59ArgGly: 4.59 ± 0.054	1.994ArgHis: 1.994 ± 0.038	3.464ArgIle: 3.464 ± 0.048	2.107ArgLys: 2.107 ± 0.039	7.654ArgLeu: 7.654 ± 0.08	1.863ArgMet: 1.863 ± 0.028	1.932ArgAsn: 1.932 ± 0.032	3.225ArgPro: 3.225 ± 0.051	3.205ArgGln: 3.205 ± 0.047	5.227ArgArg: 5.227 ± 0.065	3.097ArgSer: 3.097 ± 0.046	3.515ArgThr: 3.515 ± 0.053	4.547ArgVal: 4.547 ± 0.048	1.12ArgTrp: 1.12 ± 0.031	2.138ArgTyr: 2.138 ± 0.045	0.0ArgXaa: 0.0 ± 0.0
Ser	6.37SerAla: 6.37 ± 0.081	0.428SerCys: 0.428 ± 0.016	2.594SerAsp: 2.594 ± 0.037	2.26SerGlu: 2.26 ± 0.038	1.919SerPhe: 1.919 ± 0.035	4.982SerGly: 4.982 ± 0.07	1.136SerHis: 1.136 ± 0.026	2.361SerIle: 2.361 ± 0.04	1.547SerLys: 1.547 ± 0.028	5.091SerLeu: 5.091 ± 0.057	1.214SerMet: 1.214 ± 0.027	1.541SerAsn: 1.541 ± 0.031	2.443SerPro: 2.443 ± 0.041	1.718SerGln: 1.718 ± 0.031	3.129SerArg: 3.129 ± 0.046	2.893SerSer: 2.893 ± 0.051	2.91SerThr: 2.91 ± 0.065	3.727SerVal: 3.727 ± 0.053	0.745SerTrp: 0.745 ± 0.022	1.471SerTyr: 1.471 ± 0.031	0.0SerXaa: 0.0 ± 0.0
Thr	6.663ThrAla: 6.663 ± 0.086	0.42ThrCys: 0.42 ± 0.016	2.832ThrAsp: 2.832 ± 0.043	2.367ThrGlu: 2.367 ± 0.035	1.927ThrPhe: 1.927 ± 0.041	4.893ThrGly: 4.893 ± 0.06	1.047ThrHis: 1.047 ± 0.028	2.671ThrIle: 2.671 ± 0.045	1.405ThrLys: 1.405 ± 0.033	6.393ThrLeu: 6.393 ± 0.062	1.217ThrMet: 1.217 ± 0.031	1.44ThrAsn: 1.44 ± 0.036	3.559ThrPro: 3.559 ± 0.056	1.931ThrGln: 1.931 ± 0.045	3.265ThrArg: 3.265 ± 0.045	2.879ThrSer: 2.879 ± 0.076	3.162ThrThr: 3.162 ± 0.07	4.828ThrVal: 4.828 ± 0.058	0.775ThrTrp: 0.775 ± 0.024	1.372ThrTyr: 1.372 ± 0.029	0.0ThrXaa: 0.0 ± 0.0
Val	9.778ValAla: 9.778 ± 0.083	0.643ValCys: 0.643 ± 0.02	4.042ValAsp: 4.042 ± 0.051	4.002ValGlu: 4.002 ± 0.056	2.434ValPhe: 2.434 ± 0.041	5.334ValGly: 5.334 ± 0.063	1.496ValHis: 1.496 ± 0.025	3.319ValIle: 3.319 ± 0.046	2.479ValLys: 2.479 ± 0.043	8.061ValLeu: 8.061 ± 0.087	1.625ValMet: 1.625 ± 0.035	2.381ValAsn: 2.381 ± 0.038	4.117ValPro: 4.117 ± 0.05	2.786ValGln: 2.786 ± 0.038	5.085ValArg: 5.085 ± 0.063	3.888ValSer: 3.888 ± 0.049	4.847ValThr: 4.847 ± 0.057	5.721ValVal: 5.721 ± 0.058	0.841ValTrp: 0.841 ± 0.024	1.7ValTyr: 1.7 ± 0.034	0.0ValXaa: 0.0 ± 0.0
Trp	1.146TrpAla: 1.146 ± 0.025	0.154TrpCys: 0.154 ± 0.009	0.682TrpAsp: 0.682 ± 0.023	0.567TrpGlu: 0.567 ± 0.017	0.538TrpPhe: 0.538 ± 0.019	0.861TrpGly: 0.861 ± 0.025	0.428TrpHis: 0.428 ± 0.015	0.595TrpIle: 0.595 ± 0.019	0.438TrpLys: 0.438 ± 0.015	1.93TrpLeu: 1.93 ± 0.036	0.351TrpMet: 0.351 ± 0.014	0.491TrpAsn: 0.491 ± 0.019	0.64TrpPro: 0.64 ± 0.019	0.846TrpGln: 0.846 ± 0.025	1.288TrpArg: 1.288 ± 0.03	0.749TrpSer: 0.749 ± 0.022	0.753TrpThr: 0.753 ± 0.026	0.816TrpVal: 0.816 ± 0.024	0.263TrpTrp: 0.263 ± 0.014	0.364TrpTyr: 0.364 ± 0.015	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.829TyrAla: 2.829 ± 0.038	0.267TyrCys: 0.267 ± 0.013	1.607TyrAsp: 1.607 ± 0.038	1.243TyrGlu: 1.243 ± 0.025	1.024TyrPhe: 1.024 ± 0.028	2.26TyrGly: 2.26 ± 0.044	0.538TyrHis: 0.538 ± 0.018	0.879TyrIle: 0.879 ± 0.022	0.786TyrLys: 0.786 ± 0.022	2.59TyrLeu: 2.59 ± 0.034	0.457TyrMet: 0.457 ± 0.017	0.771TyrAsn: 0.771 ± 0.025	1.273TyrPro: 1.273 ± 0.031	1.04TyrGln: 1.04 ± 0.025	2.099TyrArg: 2.099 ± 0.036	1.344TyrSer: 1.344 ± 0.029	1.447TyrThr: 1.447 ± 0.034	1.825TyrVal: 1.825 ± 0.034	0.384TyrTrp: 0.384 ± 0.016	0.789TyrTyr: 0.789 ± 0.023	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 5145 proteins (1777161 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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