Amino acid dipepetide frequency for Nocardia cerradoensis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	22.056AlaAla: 22.056 ± 0.12	0.972AlaCys: 0.972 ± 0.025	8.933AlaAsp: 8.933 ± 0.07	8.705AlaGlu: 8.705 ± 0.062	3.283AlaPhe: 3.283 ± 0.038	12.713AlaGly: 12.713 ± 0.099	2.946AlaHis: 2.946 ± 0.04	4.945AlaIle: 4.945 ± 0.046	2.515AlaLys: 2.515 ± 0.043	13.026AlaLeu: 13.026 ± 0.086	2.659AlaMet: 2.659 ± 0.036	2.308AlaAsn: 2.308 ± 0.034	6.778AlaPro: 6.778 ± 0.072	4.124AlaGln: 4.124 ± 0.047	9.853AlaArg: 9.853 ± 0.081	5.419AlaSer: 5.419 ± 0.052	7.644AlaThr: 7.644 ± 0.065	12.082AlaVal: 12.082 ± 0.092	1.645AlaTrp: 1.645 ± 0.026	2.323AlaTyr: 2.323 ± 0.04	0.0AlaXaa: 0.0 ± 0.0
Cys	1.146CysAla: 1.146 ± 0.022	0.088CysCys: 0.088 ± 0.007	0.522CysAsp: 0.522 ± 0.016	0.388CysGlu: 0.388 ± 0.013	0.221CysPhe: 0.221 ± 0.008	0.939CysGly: 0.939 ± 0.021	0.184CysHis: 0.184 ± 0.009	0.221CysIle: 0.221 ± 0.01	0.117CysLys: 0.117 ± 0.007	0.676CysLeu: 0.676 ± 0.015	0.117CysMet: 0.117 ± 0.006	0.136CysAsn: 0.136 ± 0.008	0.504CysPro: 0.504 ± 0.016	0.163CysGln: 0.163 ± 0.008	0.639CysArg: 0.639 ± 0.017	0.453CysSer: 0.453 ± 0.014	0.454CysThr: 0.454 ± 0.014	0.637CysVal: 0.637 ± 0.016	0.127CysTrp: 0.127 ± 0.006	0.166CysTyr: 0.166 ± 0.008	0.0CysXaa: 0.0 ± 0.0
Asp	7.704AspAla: 7.704 ± 0.053	0.446AspCys: 0.446 ± 0.014	3.815AspAsp: 3.815 ± 0.042	3.83AspGlu: 3.83 ± 0.043	1.781AspPhe: 1.781 ± 0.027	5.507AspGly: 5.507 ± 0.05	1.611AspHis: 1.611 ± 0.027	2.778AspIle: 2.778 ± 0.034	1.182AspLys: 1.182 ± 0.025	6.386AspLeu: 6.386 ± 0.051	0.949AspMet: 0.949 ± 0.019	1.203AspAsn: 1.203 ± 0.021	4.813AspPro: 4.813 ± 0.049	1.706AspGln: 1.706 ± 0.03	5.525AspArg: 5.525 ± 0.051	3.096AspSer: 3.096 ± 0.036	3.519AspThr: 3.519 ± 0.041	4.551AspVal: 4.551 ± 0.052	0.978AspTrp: 0.978 ± 0.021	1.424AspTyr: 1.424 ± 0.025	0.0AspXaa: 0.0 ± 0.0
Glu	6.006GluAla: 6.006 ± 0.058	0.378GluCys: 0.378 ± 0.012	2.329GluAsp: 2.329 ± 0.034	2.388GluGlu: 2.388 ± 0.038	1.955GluPhe: 1.955 ± 0.031	3.185GluGly: 3.185 ± 0.044	1.652GluHis: 1.652 ± 0.024	2.773GluIle: 2.773 ± 0.03	1.183GluLys: 1.183 ± 0.025	6.936GluLeu: 6.936 ± 0.066	1.009GluMet: 1.009 ± 0.02	1.105GluAsn: 1.105 ± 0.023	3.367GluPro: 3.367 ± 0.04	2.504GluGln: 2.504 ± 0.031	4.96GluArg: 4.96 ± 0.048	3.042GluSer: 3.042 ± 0.033	2.899GluThr: 2.899 ± 0.034	4.306GluVal: 4.306 ± 0.042	0.835GluTrp: 0.835 ± 0.017	1.2GluTyr: 1.2 ± 0.023	0.0GluXaa: 0.0 ± 0.0
Phe	4.113PheAla: 4.113 ± 0.046	0.282PheCys: 0.282 ± 0.01	2.538PheAsp: 2.538 ± 0.035	1.584PheGlu: 1.584 ± 0.029	0.846PhePhe: 0.846 ± 0.02	3.46PheGly: 3.46 ± 0.039	0.651PheHis: 0.651 ± 0.016	0.838PheIle: 0.838 ± 0.02	0.381PheLys: 0.381 ± 0.013	2.371PheLeu: 2.371 ± 0.031	0.399PheMet: 0.399 ± 0.013	0.543PheAsn: 0.543 ± 0.014	1.405PhePro: 1.405 ± 0.024	0.67PheGln: 0.67 ± 0.018	1.907PheArg: 1.907 ± 0.029	1.489PheSer: 1.489 ± 0.025	2.041PheThr: 2.041 ± 0.031	2.456PheVal: 2.456 ± 0.034	0.398PheTrp: 0.398 ± 0.012	0.608PheTyr: 0.608 ± 0.016	0.0PheXaa: 0.0 ± 0.0
Gly	10.771GlyAla: 10.771 ± 0.089	0.796GlyCys: 0.796 ± 0.021	5.063GlyAsp: 5.063 ± 0.05	4.561GlyGlu: 4.561 ± 0.052	3.039GlyPhe: 3.039 ± 0.044	7.878GlyGly: 7.878 ± 0.081	2.135GlyHis: 2.135 ± 0.027	4.106GlyIle: 4.106 ± 0.039	2.135GlyLys: 2.135 ± 0.033	8.365GlyLeu: 8.365 ± 0.075	2.03GlyMet: 2.03 ± 0.028	1.847GlyAsn: 1.847 ± 0.029	4.829GlyPro: 4.829 ± 0.05	2.48GlyGln: 2.48 ± 0.034	7.073GlyArg: 7.073 ± 0.057	5.294GlySer: 5.294 ± 0.058	5.651GlyThr: 5.651 ± 0.049	7.23GlyVal: 7.23 ± 0.062	1.6GlyTrp: 1.6 ± 0.026	2.389GlyTyr: 2.389 ± 0.038	0.0GlyXaa: 0.0 ± 0.0
His	2.712HisAla: 2.712 ± 0.031	0.216HisCys: 0.216 ± 0.009	1.459HisAsp: 1.459 ± 0.028	1.18HisGlu: 1.18 ± 0.02	0.689HisPhe: 0.689 ± 0.016	2.244HisGly: 2.244 ± 0.031	0.754HisHis: 0.754 ± 0.02	0.911HisIle: 0.911 ± 0.02	0.336HisLys: 0.336 ± 0.011	2.27HisLeu: 2.27 ± 0.033	0.407HisMet: 0.407 ± 0.012	0.5HisAsn: 0.5 ± 0.014	1.803HisPro: 1.803 ± 0.03	0.615HisGln: 0.615 ± 0.015	2.243HisArg: 2.243 ± 0.033	1.185HisSer: 1.185 ± 0.024	1.411HisThr: 1.411 ± 0.024	1.558HisVal: 1.558 ± 0.027	0.39HisTrp: 0.39 ± 0.012	0.542HisTyr: 0.542 ± 0.015	0.0HisXaa: 0.0 ± 0.0
Ile	6.403IleAla: 6.403 ± 0.048	0.373IleCys: 0.373 ± 0.012	3.387IleAsp: 3.387 ± 0.041	2.613IleGlu: 2.613 ± 0.035	0.987IlePhe: 0.987 ± 0.021	4.536IleGly: 4.536 ± 0.042	0.825IleHis: 0.825 ± 0.021	1.244IleIle: 1.244 ± 0.022	0.638IleLys: 0.638 ± 0.016	3.089IleLeu: 3.089 ± 0.032	0.58IleMet: 0.58 ± 0.016	0.847IleAsn: 0.847 ± 0.022	2.367IlePro: 2.367 ± 0.032	0.839IleGln: 0.839 ± 0.018	2.913IleArg: 2.913 ± 0.036	2.142IleSer: 2.142 ± 0.028	2.704IleThr: 2.704 ± 0.032	3.711IleVal: 3.711 ± 0.04	0.449IleTrp: 0.449 ± 0.014	0.725IleTyr: 0.725 ± 0.018	0.0IleXaa: 0.0 ± 0.0
Lys	2.247LysAla: 2.247 ± 0.04	0.115LysCys: 0.115 ± 0.008	0.912LysAsp: 0.912 ± 0.024	0.743LysGlu: 0.743 ± 0.021	0.555LysPhe: 0.555 ± 0.013	1.299LysGly: 1.299 ± 0.027	0.406LysHis: 0.406 ± 0.012	0.901LysIle: 0.901 ± 0.02	0.539LysLys: 0.539 ± 0.02	1.942LysLeu: 1.942 ± 0.032	0.417LysMet: 0.417 ± 0.013	0.454LysAsn: 0.454 ± 0.014	1.246LysPro: 1.246 ± 0.025	0.707LysGln: 0.707 ± 0.019	1.348LysArg: 1.348 ± 0.027	1.151LysSer: 1.151 ± 0.025	1.139LysThr: 1.139 ± 0.024	1.633LysVal: 1.633 ± 0.028	0.273LysTrp: 0.273 ± 0.013	0.465LysTyr: 0.465 ± 0.014	0.0LysXaa: 0.0 ± 0.0
Leu	14.062LeuAla: 14.062 ± 0.094	0.829LeuCys: 0.829 ± 0.02	6.784LeuAsp: 6.784 ± 0.061	4.584LeuGlu: 4.584 ± 0.049	2.654LeuPhe: 2.654 ± 0.038	8.673LeuGly: 8.673 ± 0.071	2.201LeuHis: 2.201 ± 0.027	4.024LeuIle: 4.024 ± 0.046	1.375LeuLys: 1.375 ± 0.03	9.686LeuLeu: 9.686 ± 0.087	1.521LeuMet: 1.521 ± 0.028	1.825LeuAsn: 1.825 ± 0.031	6.054LeuPro: 6.054 ± 0.062	2.336LeuGln: 2.336 ± 0.03	8.417LeuArg: 8.417 ± 0.058	5.43LeuSer: 5.43 ± 0.043	6.324LeuThr: 6.324 ± 0.055	8.069LeuVal: 8.069 ± 0.064	1.195LeuTrp: 1.195 ± 0.024	1.687LeuTyr: 1.687 ± 0.028	0.0LeuXaa: 0.0 ± 0.0
Met	2.292MetAla: 2.292 ± 0.031	0.165MetCys: 0.165 ± 0.008	0.844MetAsp: 0.844 ± 0.018	0.659MetGlu: 0.659 ± 0.018	0.579MetPhe: 0.579 ± 0.016	1.297MetGly: 1.297 ± 0.027	0.42MetHis: 0.42 ± 0.013	0.874MetIle: 0.874 ± 0.019	0.389MetLys: 0.389 ± 0.014	1.893MetLeu: 1.893 ± 0.027	0.372MetMet: 0.372 ± 0.012	0.522MetAsn: 0.522 ± 0.015	1.191MetPro: 1.191 ± 0.02	0.499MetGln: 0.499 ± 0.016	1.551MetArg: 1.551 ± 0.024	1.555MetSer: 1.555 ± 0.025	1.681MetThr: 1.681 ± 0.025	1.515MetVal: 1.515 ± 0.026	0.247MetTrp: 0.247 ± 0.01	0.34MetTyr: 0.34 ± 0.013	0.0MetXaa: 0.0 ± 0.0
Asn	2.403AsnAla: 2.403 ± 0.036	0.158AsnCys: 0.158 ± 0.007	1.032AsnAsp: 1.032 ± 0.019	0.886AsnGlu: 0.886 ± 0.019	0.606AsnPhe: 0.606 ± 0.016	1.901AsnGly: 1.901 ± 0.029	0.435AsnHis: 0.435 ± 0.014	0.863AsnIle: 0.863 ± 0.019	0.398AsnLys: 0.398 ± 0.013	1.903AsnLeu: 1.903 ± 0.031	0.36AsnMet: 0.36 ± 0.012	0.458AsnAsn: 0.458 ± 0.015	1.649AsnPro: 1.649 ± 0.026	0.585AsnGln: 0.585 ± 0.015	1.526AsnArg: 1.526 ± 0.025	1.184AsnSer: 1.184 ± 0.021	1.228AsnThr: 1.228 ± 0.023	1.406AsnVal: 1.406 ± 0.022	0.337AsnTrp: 0.337 ± 0.012	0.496AsnTyr: 0.496 ± 0.014	0.0AsnXaa: 0.0 ± 0.0
Pro	8.425ProAla: 8.425 ± 0.074	0.304ProCys: 0.304 ± 0.013	4.654ProAsp: 4.654 ± 0.044	4.146ProGlu: 4.146 ± 0.043	1.518ProPhe: 1.518 ± 0.023	6.202ProGly: 6.202 ± 0.065	1.329ProHis: 1.329 ± 0.024	2.226ProIle: 2.226 ± 0.032	1.186ProLys: 1.186 ± 0.024	4.822ProLeu: 4.822 ± 0.04	1.15ProMet: 1.15 ± 0.019	1.205ProAsn: 1.205 ± 0.024	3.399ProPro: 3.399 ± 0.051	1.924ProGln: 1.924 ± 0.032	3.867ProArg: 3.867 ± 0.043	2.951ProSer: 2.951 ± 0.038	3.301ProThr: 3.301 ± 0.04	5.25ProVal: 5.25 ± 0.056	0.841ProTrp: 0.841 ± 0.017	1.153ProTyr: 1.153 ± 0.024	0.0ProXaa: 0.0 ± 0.0
Gln	3.563GlnAla: 3.563 ± 0.042	0.207GlnCys: 0.207 ± 0.008	1.134GlnAsp: 1.134 ± 0.024	1.073GlnGlu: 1.073 ± 0.019	0.891GlnPhe: 0.891 ± 0.021	1.934GlnGly: 1.934 ± 0.03	0.727GlnHis: 0.727 ± 0.018	1.42GlnIle: 1.42 ± 0.024	0.523GlnLys: 0.523 ± 0.016	3.479GlnLeu: 3.479 ± 0.04	0.601GlnMet: 0.601 ± 0.016	0.566GlnAsn: 0.566 ± 0.015	1.883GlnPro: 1.883 ± 0.035	1.416GlnGln: 1.416 ± 0.031	2.892GlnArg: 2.892 ± 0.043	1.353GlnSer: 1.353 ± 0.022	1.42GlnThr: 1.42 ± 0.026	2.569GlnVal: 2.569 ± 0.034	0.59GlnTrp: 0.59 ± 0.015	0.615GlnTyr: 0.615 ± 0.014	0.0GlnXaa: 0.0 ± 0.0
Arg	9.623ArgAla: 9.623 ± 0.08	0.639ArgCys: 0.639 ± 0.017	4.585ArgAsp: 4.585 ± 0.043	4.475ArgGlu: 4.475 ± 0.044	2.491ArgPhe: 2.491 ± 0.032	5.55ArgGly: 5.55 ± 0.052	2.047ArgHis: 2.047 ± 0.031	4.08ArgIle: 4.08 ± 0.038	1.584ArgLys: 1.584 ± 0.025	7.993ArgLeu: 7.993 ± 0.07	2.036ArgMet: 2.036 ± 0.028	1.646ArgAsn: 1.646 ± 0.026	4.626ArgPro: 4.626 ± 0.053	2.331ArgGln: 2.331 ± 0.03	7.524ArgArg: 7.524 ± 0.081	4.283ArgSer: 4.283 ± 0.038	5.165ArgThr: 5.165 ± 0.047	5.789ArgVal: 5.789 ± 0.052	1.458ArgTrp: 1.458 ± 0.023	2.016ArgTyr: 2.016 ± 0.028	0.0ArgXaa: 0.0 ± 0.0
Ser	7.274SerAla: 7.274 ± 0.058	0.407SerCys: 0.407 ± 0.013	3.209SerAsp: 3.209 ± 0.036	2.669SerGlu: 2.669 ± 0.03	1.542SerPhe: 1.542 ± 0.024	6.094SerGly: 6.094 ± 0.068	1.015SerHis: 1.015 ± 0.021	2.078SerIle: 2.078 ± 0.028	0.985SerLys: 0.985 ± 0.019	4.421SerLeu: 4.421 ± 0.044	1.234SerMet: 1.234 ± 0.023	1.029SerAsn: 1.029 ± 0.022	3.008SerPro: 3.008 ± 0.041	1.269SerGln: 1.269 ± 0.026	3.72SerArg: 3.72 ± 0.033	2.914SerSer: 2.914 ± 0.039	3.262SerThr: 3.262 ± 0.038	4.36SerVal: 4.36 ± 0.041	0.872SerTrp: 0.872 ± 0.017	1.111SerTyr: 1.111 ± 0.019	0.0SerXaa: 0.0 ± 0.0
Thr	8.599ThrAla: 8.599 ± 0.064	0.418ThrCys: 0.418 ± 0.014	3.934ThrAsp: 3.934 ± 0.04	3.373ThrGlu: 3.373 ± 0.037	1.682ThrPhe: 1.682 ± 0.028	6.218ThrGly: 6.218 ± 0.047	1.267ThrHis: 1.267 ± 0.021	2.363ThrIle: 2.363 ± 0.031	1.056ThrLys: 1.056 ± 0.024	5.618ThrLeu: 5.618 ± 0.046	1.053ThrMet: 1.053 ± 0.019	1.051ThrAsn: 1.051 ± 0.021	4.005ThrPro: 4.005 ± 0.041	1.407ThrGln: 1.407 ± 0.025	3.97ThrArg: 3.97 ± 0.04	3.142ThrSer: 3.142 ± 0.04	4.157ThrThr: 4.157 ± 0.054	6.084ThrVal: 6.084 ± 0.06	0.814ThrTrp: 0.814 ± 0.017	1.227ThrTyr: 1.227 ± 0.021	0.0ThrXaa: 0.0 ± 0.0
Val	11.556ValAla: 11.556 ± 0.088	0.718ValCys: 0.718 ± 0.019	5.522ValAsp: 5.522 ± 0.046	4.436ValGlu: 4.436 ± 0.047	2.423ValPhe: 2.423 ± 0.029	6.636ValGly: 6.636 ± 0.06	1.942ValHis: 1.942 ± 0.029	3.428ValIle: 3.428 ± 0.036	1.337ValLys: 1.337 ± 0.027	8.841ValLeu: 8.841 ± 0.078	1.389ValMet: 1.389 ± 0.026	1.723ValAsn: 1.723 ± 0.026	4.952ValPro: 4.952 ± 0.053	2.039ValGln: 2.039 ± 0.031	6.643ValArg: 6.643 ± 0.054	4.346ValSer: 4.346 ± 0.041	5.36ValThr: 5.36 ± 0.047	8.482ValVal: 8.482 ± 0.074	1.036ValTrp: 1.036 ± 0.02	1.474ValTyr: 1.474 ± 0.021	0.0ValXaa: 0.0 ± 0.0
Trp	1.562TrpAla: 1.562 ± 0.024	0.177TrpCys: 0.177 ± 0.008	0.802TrpAsp: 0.802 ± 0.016	0.7TrpGlu: 0.7 ± 0.017	0.527TrpPhe: 0.527 ± 0.016	0.995TrpGly: 0.995 ± 0.019	0.386TrpHis: 0.386 ± 0.013	0.643TrpIle: 0.643 ± 0.017	0.315TrpLys: 0.315 ± 0.011	1.675TrpLeu: 1.675 ± 0.026	0.313TrpMet: 0.313 ± 0.01	0.415TrpAsn: 0.415 ± 0.014	0.772TrpPro: 0.772 ± 0.019	0.61TrpGln: 0.61 ± 0.017	1.311TrpArg: 1.311 ± 0.026	0.939TrpSer: 0.939 ± 0.02	0.928TrpThr: 0.928 ± 0.02	1.069TrpVal: 1.069 ± 0.021	0.33TrpTrp: 0.33 ± 0.012	0.312TrpTyr: 0.312 ± 0.012	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.409TyrAla: 2.409 ± 0.032	0.212TyrCys: 0.212 ± 0.011	1.346TyrAsp: 1.346 ± 0.028	1.021TyrGlu: 1.021 ± 0.021	0.713TyrPhe: 0.713 ± 0.016	2.013TyrGly: 2.013 ± 0.03	0.489TyrHis: 0.489 ± 0.013	0.655TyrIle: 0.655 ± 0.016	0.318TyrLys: 0.318 ± 0.012	2.339TyrLeu: 2.339 ± 0.033	0.289TyrMet: 0.289 ± 0.013	0.429TyrAsn: 0.429 ± 0.014	1.202TyrPro: 1.202 ± 0.026	0.633TyrGln: 0.633 ± 0.017	2.059TyrArg: 2.059 ± 0.03	1.104TyrSer: 1.104 ± 0.022	1.152TyrThr: 1.152 ± 0.019	1.526TyrVal: 1.526 ± 0.03	0.364TyrTrp: 0.364 ± 0.012	0.478TyrTyr: 0.478 ± 0.014	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 8308 proteins (2632396 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

---