Amino acid dipepetide frequency for Halomonas sp. A11-A

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	14.486AlaAla: 14.486 ± 0.187	1.237AlaCys: 1.237 ± 0.038	5.937AlaAsp: 5.937 ± 0.078	9.16AlaGlu: 9.16 ± 0.126	4.144AlaPhe: 4.144 ± 0.072	10.164AlaGly: 10.164 ± 0.13	2.497AlaHis: 2.497 ± 0.051	5.458AlaIle: 5.458 ± 0.083	2.51AlaLys: 2.51 ± 0.065	15.443AlaLeu: 15.443 ± 0.184	3.38AlaMet: 3.38 ± 0.066	2.453AlaAsn: 2.453 ± 0.048	5.59AlaPro: 5.59 ± 0.106	3.771AlaGln: 3.771 ± 0.067	9.713AlaArg: 9.713 ± 0.126	6.169AlaSer: 6.169 ± 0.087	5.428AlaThr: 5.428 ± 0.068	7.914AlaVal: 7.914 ± 0.095	2.151AlaTrp: 2.151 ± 0.054	2.291AlaTyr: 2.291 ± 0.055	0.0AlaXaa: 0.0 ± 0.0
Cys	0.897CysAla: 0.897 ± 0.031	0.121CysCys: 0.121 ± 0.012	0.543CysAsp: 0.543 ± 0.022	0.528CysGlu: 0.528 ± 0.023	0.313CysPhe: 0.313 ± 0.018	0.908CysGly: 0.908 ± 0.031	0.341CysHis: 0.341 ± 0.021	0.314CysIle: 0.314 ± 0.018	0.19CysLys: 0.19 ± 0.012	1.056CysLeu: 1.056 ± 0.035	0.179CysMet: 0.179 ± 0.015	0.17CysAsn: 0.17 ± 0.013	0.539CysPro: 0.539 ± 0.027	0.331CysGln: 0.331 ± 0.018	0.793CysArg: 0.793 ± 0.029	0.416CysSer: 0.416 ± 0.022	0.348CysThr: 0.348 ± 0.018	0.582CysVal: 0.582 ± 0.026	0.113CysTrp: 0.113 ± 0.011	0.195CysTyr: 0.195 ± 0.013	0.0CysXaa: 0.0 ± 0.0
Asp	6.608AspAla: 6.608 ± 0.09	0.418AspCys: 0.418 ± 0.022	3.554AspAsp: 3.554 ± 0.067	4.261AspGlu: 4.261 ± 0.07	2.055AspPhe: 2.055 ± 0.05	4.551AspGly: 4.551 ± 0.073	1.468AspHis: 1.468 ± 0.044	2.483AspIle: 2.483 ± 0.049	1.306AspLys: 1.306 ± 0.042	5.613AspLeu: 5.613 ± 0.09	1.141AspMet: 1.141 ± 0.035	1.301AspAsn: 1.301 ± 0.045	3.237AspPro: 3.237 ± 0.055	1.791AspGln: 1.791 ± 0.042	3.804AspArg: 3.804 ± 0.062	2.377AspSer: 2.377 ± 0.052	2.562AspThr: 2.562 ± 0.06	3.471AspVal: 3.471 ± 0.056	0.963AspTrp: 0.963 ± 0.031	1.56AspTyr: 1.56 ± 0.042	0.0AspXaa: 0.0 ± 0.0
Glu	10.227GluAla: 10.227 ± 0.148	0.469GluCys: 0.469 ± 0.019	2.753GluAsp: 2.753 ± 0.057	4.907GluGlu: 4.907 ± 0.085	1.699GluPhe: 1.699 ± 0.045	5.614GluGly: 5.614 ± 0.07	1.734GluHis: 1.734 ± 0.048	3.159GluIle: 3.159 ± 0.067	1.923GluLys: 1.923 ± 0.05	7.644GluLeu: 7.644 ± 0.087	1.573GluMet: 1.573 ± 0.039	1.377GluAsn: 1.377 ± 0.043	3.211GluPro: 3.211 ± 0.073	3.26GluGln: 3.26 ± 0.067	6.989GluArg: 6.989 ± 0.1	3.164GluSer: 3.164 ± 0.053	3.187GluThr: 3.187 ± 0.053	5.496GluVal: 5.496 ± 0.08	0.929GluTrp: 0.929 ± 0.033	1.141GluTyr: 1.141 ± 0.033	0.0GluXaa: 0.0 ± 0.0
Phe	3.685PheAla: 3.685 ± 0.074	0.375PheCys: 0.375 ± 0.019	2.344PheAsp: 2.344 ± 0.051	2.238PheGlu: 2.238 ± 0.043	1.199PhePhe: 1.199 ± 0.038	3.121PheGly: 3.121 ± 0.06	0.811PheHis: 0.811 ± 0.027	1.499PheIle: 1.499 ± 0.038	0.847PheLys: 0.847 ± 0.033	3.298PheLeu: 3.298 ± 0.059	0.804PheMet: 0.804 ± 0.031	0.975PheAsn: 0.975 ± 0.032	1.49PhePro: 1.49 ± 0.041	1.137PheGln: 1.137 ± 0.038	2.141PheArg: 2.141 ± 0.05	1.97PheSer: 1.97 ± 0.045	1.885PheThr: 1.885 ± 0.043	2.316PheVal: 2.316 ± 0.054	0.455PheTrp: 0.455 ± 0.025	0.868PheTyr: 0.868 ± 0.031	0.0PheXaa: 0.0 ± 0.0
Gly	7.918GlyAla: 7.918 ± 0.111	0.909GlyCys: 0.909 ± 0.032	4.433GlyAsp: 4.433 ± 0.069	6.764GlyGlu: 6.764 ± 0.079	3.139GlyPhe: 3.139 ± 0.052	6.914GlyGly: 6.914 ± 0.096	2.114GlyHis: 2.114 ± 0.049	4.222GlyIle: 4.222 ± 0.067	2.531GlyLys: 2.531 ± 0.058	9.892GlyLeu: 9.892 ± 0.133	2.503GlyMet: 2.503 ± 0.063	1.909GlyAsn: 1.909 ± 0.048	3.014GlyPro: 3.014 ± 0.062	3.245GlyGln: 3.245 ± 0.059	6.378GlyArg: 6.378 ± 0.105	4.244GlySer: 4.244 ± 0.07	3.539GlyThr: 3.539 ± 0.06	6.413GlyVal: 6.413 ± 0.089	1.43GlyTrp: 1.43 ± 0.038	2.301GlyTyr: 2.301 ± 0.048	0.0GlyXaa: 0.0 ± 0.0
His	2.589HisAla: 2.589 ± 0.054	0.3HisCys: 0.3 ± 0.017	1.523HisAsp: 1.523 ± 0.049	1.41HisGlu: 1.41 ± 0.036	0.976HisPhe: 0.976 ± 0.031	2.324HisGly: 2.324 ± 0.057	0.809HisHis: 0.809 ± 0.033	0.84HisIle: 0.84 ± 0.029	0.551HisLys: 0.551 ± 0.026	2.757HisLeu: 2.757 ± 0.056	0.446HisMet: 0.446 ± 0.02	0.508HisAsn: 0.508 ± 0.023	1.63HisPro: 1.63 ± 0.047	0.903HisGln: 0.903 ± 0.03	2.005HisArg: 2.005 ± 0.049	1.033HisSer: 1.033 ± 0.033	0.957HisThr: 0.957 ± 0.029	1.372HisVal: 1.372 ± 0.033	0.421HisTrp: 0.421 ± 0.019	0.792HisTyr: 0.792 ± 0.028	0.0HisXaa: 0.0 ± 0.0
Ile	5.436IleAla: 5.436 ± 0.082	0.389IleCys: 0.389 ± 0.02	3.19IleAsp: 3.19 ± 0.061	3.564IleGlu: 3.564 ± 0.063	1.343IlePhe: 1.343 ± 0.041	4.04IleGly: 4.04 ± 0.076	1.039IleHis: 1.039 ± 0.033	1.865IleIle: 1.865 ± 0.05	1.246IleLys: 1.246 ± 0.041	3.821IleLeu: 3.821 ± 0.073	0.848IleMet: 0.848 ± 0.033	1.352IleAsn: 1.352 ± 0.039	2.096IlePro: 2.096 ± 0.049	1.353IleGln: 1.353 ± 0.038	3.006IleArg: 3.006 ± 0.055	2.342IleSer: 2.342 ± 0.049	2.491IleThr: 2.491 ± 0.052	3.008IleVal: 3.008 ± 0.065	0.434IleTrp: 0.434 ± 0.022	0.931IleTyr: 0.931 ± 0.034	0.0IleXaa: 0.0 ± 0.0
Lys	3.251LysAla: 3.251 ± 0.076	0.151LysCys: 0.151 ± 0.013	1.109LysAsp: 1.109 ± 0.038	1.533LysGlu: 1.533 ± 0.052	0.606LysPhe: 0.606 ± 0.026	2.134LysGly: 2.134 ± 0.054	0.535LysHis: 0.535 ± 0.025	1.033LysIle: 1.033 ± 0.037	0.97LysLys: 0.97 ± 0.039	2.542LysLeu: 2.542 ± 0.057	0.574LysMet: 0.574 ± 0.029	0.575LysAsn: 0.575 ± 0.024	1.369LysPro: 1.369 ± 0.04	1.031LysGln: 1.031 ± 0.039	2.255LysArg: 2.255 ± 0.057	1.355LysSer: 1.355 ± 0.044	1.206LysThr: 1.206 ± 0.034	2.067LysVal: 2.067 ± 0.05	0.27LysTrp: 0.27 ± 0.017	0.497LysTyr: 0.497 ± 0.026	0.0LysXaa: 0.0 ± 0.0
Leu	17.189LeuAla: 17.189 ± 0.225	1.083LeuCys: 1.083 ± 0.029	7.151LeuAsp: 7.151 ± 0.094	8.196LeuGlu: 8.196 ± 0.12	3.858LeuPhe: 3.858 ± 0.073	9.909LeuGly: 9.909 ± 0.106	2.464LeuHis: 2.464 ± 0.044	4.954LeuIle: 4.954 ± 0.086	3.237LeuLys: 3.237 ± 0.064	13.185LeuLeu: 13.185 ± 0.18	2.766LeuMet: 2.766 ± 0.051	2.559LeuAsn: 2.559 ± 0.055	6.695LeuPro: 6.695 ± 0.086	3.097LeuGln: 3.097 ± 0.066	7.581LeuArg: 7.581 ± 0.1	6.151LeuSer: 6.151 ± 0.081	5.901LeuThr: 5.901 ± 0.072	8.691LeuVal: 8.691 ± 0.116	1.502LeuTrp: 1.502 ± 0.044	2.281LeuTyr: 2.281 ± 0.057	0.0LeuXaa: 0.0 ± 0.0
Met	3.191MetAla: 3.191 ± 0.056	0.129MetCys: 0.129 ± 0.012	1.046MetAsp: 1.046 ± 0.033	1.268MetGlu: 1.268 ± 0.037	0.591MetPhe: 0.591 ± 0.025	1.872MetGly: 1.872 ± 0.049	0.488MetHis: 0.488 ± 0.022	1.151MetIle: 1.151 ± 0.032	0.762MetLys: 0.762 ± 0.031	2.592MetLeu: 2.592 ± 0.06	0.607MetMet: 0.607 ± 0.027	0.723MetAsn: 0.723 ± 0.024	1.427MetPro: 1.427 ± 0.039	0.887MetGln: 0.887 ± 0.031	1.653MetArg: 1.653 ± 0.039	1.721MetSer: 1.721 ± 0.044	1.633MetThr: 1.633 ± 0.046	1.695MetVal: 1.695 ± 0.045	0.171MetTrp: 0.171 ± 0.013	0.297MetTyr: 0.297 ± 0.02	0.0MetXaa: 0.0 ± 0.0
Asn	2.716AsnAla: 2.716 ± 0.056	0.195AsnCys: 0.195 ± 0.014	1.217AsnAsp: 1.217 ± 0.041	1.193AsnGlu: 1.193 ± 0.033	0.731AsnPhe: 0.731 ± 0.032	1.843AsnGly: 1.843 ± 0.046	0.54AsnHis: 0.54 ± 0.02	1.079AsnIle: 1.079 ± 0.034	0.506AsnLys: 0.506 ± 0.023	2.59AsnLeu: 2.59 ± 0.054	0.459AsnMet: 0.459 ± 0.023	0.568AsnAsn: 0.568 ± 0.028	1.626AsnPro: 1.626 ± 0.045	0.819AsnGln: 0.819 ± 0.028	1.862AsnArg: 1.862 ± 0.042	0.978AsnSer: 0.978 ± 0.031	1.082AsnThr: 1.082 ± 0.033	1.673AsnVal: 1.673 ± 0.046	0.281AsnTrp: 0.281 ± 0.018	0.582AsnTyr: 0.582 ± 0.028	0.0AsnXaa: 0.0 ± 0.0
Pro	6.146ProAla: 6.146 ± 0.097	0.359ProCys: 0.359 ± 0.02	3.266ProAsp: 3.266 ± 0.06	4.553ProGlu: 4.553 ± 0.076	1.737ProPhe: 1.737 ± 0.045	4.79ProGly: 4.79 ± 0.073	1.175ProHis: 1.175 ± 0.036	1.901ProIle: 1.901 ± 0.048	1.156ProLys: 1.156 ± 0.057	6.04ProLeu: 6.04 ± 0.08	1.286ProMet: 1.286 ± 0.032	1.057ProAsn: 1.057 ± 0.039	2.631ProPro: 2.631 ± 0.069	1.622ProGln: 1.622 ± 0.04	3.608ProArg: 3.608 ± 0.066	2.455ProSer: 2.455 ± 0.051	2.151ProThr: 2.151 ± 0.048	3.932ProVal: 3.932 ± 0.072	0.912ProTrp: 0.912 ± 0.032	1.026ProTyr: 1.026 ± 0.034	0.0ProXaa: 0.0 ± 0.0
Gln	5.417GlnAla: 5.417 ± 0.104	0.255GlnCys: 0.255 ± 0.015	1.426GlnAsp: 1.426 ± 0.043	2.09GlnGlu: 2.09 ± 0.05	1.033GlnPhe: 1.033 ± 0.03	3.082GlnGly: 3.082 ± 0.052	0.811GlnHis: 0.811 ± 0.033	1.329GlnIle: 1.329 ± 0.045	0.868GlnLys: 0.868 ± 0.039	4.019GlnLeu: 4.019 ± 0.078	0.785GlnMet: 0.785 ± 0.029	0.681GlnAsn: 0.681 ± 0.026	1.781GlnPro: 1.781 ± 0.041	1.826GlnGln: 1.826 ± 0.052	3.481GlnArg: 3.481 ± 0.061	1.543GlnSer: 1.543 ± 0.038	1.425GlnThr: 1.425 ± 0.043	2.847GlnVal: 2.847 ± 0.052	0.546GlnTrp: 0.546 ± 0.024	0.626GlnTyr: 0.626 ± 0.024	0.0GlnXaa: 0.0 ± 0.0
Arg	7.501ArgAla: 7.501 ± 0.109	0.647ArgCys: 0.647 ± 0.026	4.51ArgAsp: 4.51 ± 0.074	6.214ArgGlu: 6.214 ± 0.094	3.015ArgPhe: 3.015 ± 0.062	5.243ArgGly: 5.243 ± 0.071	2.5ArgHis: 2.5 ± 0.058	3.404ArgIle: 3.404 ± 0.059	1.731ArgLys: 1.731 ± 0.041	11.548ArgLeu: 11.548 ± 0.171	1.799ArgMet: 1.799 ± 0.042	1.549ArgAsn: 1.549 ± 0.039	3.67ArgPro: 3.67 ± 0.064	3.544ArgGln: 3.544 ± 0.075	6.997ArgArg: 6.997 ± 0.112	3.156ArgSer: 3.156 ± 0.06	2.908ArgThr: 2.908 ± 0.057	5.536ArgVal: 5.536 ± 0.078	1.222ArgTrp: 1.222 ± 0.039	2.087ArgTyr: 2.087 ± 0.043	0.0ArgXaa: 0.0 ± 0.0
Ser	5.322SerAla: 5.322 ± 0.074	0.398SerCys: 0.398 ± 0.021	2.609SerAsp: 2.609 ± 0.057	2.914SerGlu: 2.914 ± 0.06	1.658SerPhe: 1.658 ± 0.04	4.811SerGly: 4.811 ± 0.068	1.196SerHis: 1.196 ± 0.034	1.991SerIle: 1.991 ± 0.048	1.127SerLys: 1.127 ± 0.034	6.244SerLeu: 6.244 ± 0.099	1.171SerMet: 1.171 ± 0.038	1.052SerAsn: 1.052 ± 0.036	2.879SerPro: 2.879 ± 0.058	1.796SerGln: 1.796 ± 0.047	4.332SerArg: 4.332 ± 0.072	2.38SerSer: 2.38 ± 0.067	2.183SerThr: 2.183 ± 0.052	3.417SerVal: 3.417 ± 0.05	0.698SerTrp: 0.698 ± 0.024	1.019SerTyr: 1.019 ± 0.032	0.0SerXaa: 0.0 ± 0.0
Thr	5.031ThrAla: 5.031 ± 0.077	0.42ThrCys: 0.42 ± 0.024	2.219ThrAsp: 2.219 ± 0.055	2.465ThrGlu: 2.465 ± 0.049	1.71ThrPhe: 1.71 ± 0.044	4.18ThrGly: 4.18 ± 0.063	1.069ThrHis: 1.069 ± 0.034	1.833ThrIle: 1.833 ± 0.047	0.823ThrLys: 0.823 ± 0.029	7.114ThrLeu: 7.114 ± 0.101	0.867ThrMet: 0.867 ± 0.032	1.011ThrAsn: 1.011 ± 0.033	3.355ThrPro: 3.355 ± 0.056	1.469ThrGln: 1.469 ± 0.039	3.875ThrArg: 3.875 ± 0.066	2.153ThrSer: 2.153 ± 0.054	2.333ThrThr: 2.333 ± 0.054	3.295ThrVal: 3.295 ± 0.064	0.62ThrTrp: 0.62 ± 0.023	0.96ThrTyr: 0.96 ± 0.03	0.0ThrXaa: 0.0 ± 0.0
Val	8.83ValAla: 8.83 ± 0.102	0.609ValCys: 0.609 ± 0.022	4.041ValAsp: 4.041 ± 0.073	5.306ValGlu: 5.306 ± 0.087	2.361ValPhe: 2.361 ± 0.05	5.515ValGly: 5.515 ± 0.083	1.512ValHis: 1.512 ± 0.046	3.874ValIle: 3.874 ± 0.065	1.999ValLys: 1.999 ± 0.054	7.728ValLeu: 7.728 ± 0.105	1.963ValMet: 1.963 ± 0.048	1.92ValAsn: 1.92 ± 0.044	3.557ValPro: 3.557 ± 0.057	2.125ValGln: 2.125 ± 0.049	4.752ValArg: 4.752 ± 0.078	3.847ValSer: 3.847 ± 0.066	4.054ValThr: 4.054 ± 0.069	6.02ValVal: 6.02 ± 0.087	0.81ValTrp: 0.81 ± 0.03	1.426ValTyr: 1.426 ± 0.037	0.0ValXaa: 0.0 ± 0.0
Trp	1.212TrpAla: 1.212 ± 0.042	0.172TrpCys: 0.172 ± 0.012	0.503TrpAsp: 0.503 ± 0.022	0.808TrpGlu: 0.808 ± 0.027	0.5TrpPhe: 0.5 ± 0.024	0.913TrpGly: 0.913 ± 0.036	0.433TrpHis: 0.433 ± 0.022	0.605TrpIle: 0.605 ± 0.024	0.352TrpLys: 0.352 ± 0.019	2.533TrpLeu: 2.533 ± 0.061	0.351TrpMet: 0.351 ± 0.018	0.305TrpAsn: 0.305 ± 0.017	0.788TrpPro: 0.788 ± 0.031	0.945TrpGln: 0.945 ± 0.03	1.324TrpArg: 1.324 ± 0.045	0.692TrpSer: 0.692 ± 0.026	0.546TrpThr: 0.546 ± 0.021	0.973TrpVal: 0.973 ± 0.03	0.313TrpTrp: 0.313 ± 0.019	0.315TrpTyr: 0.315 ± 0.019	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.247TyrAla: 2.247 ± 0.051	0.243TyrCys: 0.243 ± 0.017	1.149TyrAsp: 1.149 ± 0.034	1.083TyrGlu: 1.083 ± 0.036	0.789TyrPhe: 0.789 ± 0.028	1.884TyrGly: 1.884 ± 0.05	0.609TyrHis: 0.609 ± 0.022	0.801TyrIle: 0.801 ± 0.03	0.428TyrLys: 0.428 ± 0.021	2.792TyrLeu: 2.792 ± 0.061	0.401TyrMet: 0.401 ± 0.019	0.494TyrAsn: 0.494 ± 0.023	1.218TyrPro: 1.218 ± 0.042	0.92TyrGln: 0.92 ± 0.038	2.232TyrArg: 2.232 ± 0.047	1.052TyrSer: 1.052 ± 0.034	0.982TyrThr: 0.982 ± 0.031	1.527TyrVal: 1.527 ± 0.035	0.343TyrTrp: 0.343 ± 0.018	0.598TyrTyr: 0.598 ± 0.024	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3109 proteins (993874 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

---