Amino acid dipepetide frequency for Anaeroplasma bactoclasticum

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
3.588AlaAla: 3.588 ± 0.11
0.801AlaCys: 0.801 ± 0.033
2.692AlaAsp: 2.692 ± 0.073
3.358AlaGlu: 3.358 ± 0.112
3.005AlaPhe: 3.005 ± 0.102
3.435AlaGly: 3.435 ± 0.087
0.941AlaHis: 0.941 ± 0.04
5.441AlaIle: 5.441 ± 0.092
5.397AlaLys: 5.397 ± 0.113
6.26AlaLeu: 6.26 ± 0.099
1.562AlaMet: 1.562 ± 0.055
2.834AlaAsn: 2.834 ± 0.075
1.449AlaPro: 1.449 ± 0.045
1.207AlaGln: 1.207 ± 0.048
2.021AlaArg: 2.021 ± 0.056
4.151AlaSer: 4.151 ± 0.074
3.165AlaThr: 3.165 ± 0.099
3.61AlaVal: 3.61 ± 0.093
0.452AlaTrp: 0.452 ± 0.028
2.988AlaTyr: 2.988 ± 0.066
0.0AlaXaa: 0.0 ± 0.0
Cys
0.752CysAla: 0.752 ± 0.035
0.184CysCys: 0.184 ± 0.019
0.807CysAsp: 0.807 ± 0.041
0.737CysGlu: 0.737 ± 0.033
0.57CysPhe: 0.57 ± 0.029
1.246CysGly: 1.246 ± 0.048
0.317CysHis: 0.317 ± 0.026
0.962CysIle: 0.962 ± 0.044
1.032CysLys: 1.032 ± 0.044
1.071CysLeu: 1.071 ± 0.045
0.296CysMet: 0.296 ± 0.023
0.758CysAsn: 0.758 ± 0.039
0.502CysPro: 0.502 ± 0.03
0.301CysGln: 0.301 ± 0.022
0.313CysArg: 0.313 ± 0.018
0.76CysSer: 0.76 ± 0.04
0.505CysThr: 0.505 ± 0.032
0.766CysVal: 0.766 ± 0.034
0.076CysTrp: 0.076 ± 0.01
0.681CysTyr: 0.681 ± 0.035
0.0CysXaa: 0.0 ± 0.0
Asp
3.397AspAla: 3.397 ± 0.074
0.789AspCys: 0.789 ± 0.037
3.662AspAsp: 3.662 ± 0.101
4.899AspGlu: 4.899 ± 0.113
3.272AspPhe: 3.272 ± 0.08
3.932AspGly: 3.932 ± 0.086
0.819AspHis: 0.819 ± 0.035
5.842AspIle: 5.842 ± 0.107
4.946AspLys: 4.946 ± 0.109
5.929AspLeu: 5.929 ± 0.099
1.494AspMet: 1.494 ± 0.046
3.597AspAsn: 3.597 ± 0.091
1.625AspPro: 1.625 ± 0.055
1.079AspGln: 1.079 ± 0.04
1.662AspArg: 1.662 ± 0.054
4.487AspSer: 4.487 ± 0.094
3.147AspThr: 3.147 ± 0.065
3.65AspVal: 3.65 ± 0.083
0.418AspTrp: 0.418 ± 0.027
3.934AspTyr: 3.934 ± 0.089
0.0AspXaa: 0.0 ± 0.0
Glu
5.144GluAla: 5.144 ± 0.117
0.814GluCys: 0.814 ± 0.039
4.484GluAsp: 4.484 ± 0.109
7.287GluGlu: 7.287 ± 0.178
3.332GluPhe: 3.332 ± 0.067
3.551GluGly: 3.551 ± 0.082
0.914GluHis: 0.914 ± 0.039
6.274GluIle: 6.274 ± 0.099
6.169GluLys: 6.169 ± 0.12
6.473GluLeu: 6.473 ± 0.107
2.026GluMet: 2.026 ± 0.06
4.567GluAsn: 4.567 ± 0.087
1.45GluPro: 1.45 ± 0.053
1.335GluGln: 1.335 ± 0.049
2.5GluArg: 2.5 ± 0.074
3.502GluSer: 3.502 ± 0.077
3.107GluThr: 3.107 ± 0.075
4.334GluVal: 4.334 ± 0.082
0.506GluTrp: 0.506 ± 0.029
4.19GluTyr: 4.19 ± 0.084
0.0GluXaa: 0.0 ± 0.0
Phe
2.506PheAla: 2.506 ± 0.066
0.55PheCys: 0.55 ± 0.035
3.369PheAsp: 3.369 ± 0.066
2.881PheGlu: 2.881 ± 0.059
2.183PhePhe: 2.183 ± 0.076
2.98PheGly: 2.98 ± 0.073
0.767PheHis: 0.767 ± 0.035
4.319PheIle: 4.319 ± 0.098
3.771PheLys: 3.771 ± 0.076
4.109PheLeu: 4.109 ± 0.091
1.261PheMet: 1.261 ± 0.043
3.009PheAsn: 3.009 ± 0.065
1.151PhePro: 1.151 ± 0.044
1.091PheGln: 1.091 ± 0.041
1.344PheArg: 1.344 ± 0.046
3.094PheSer: 3.094 ± 0.076
2.583PheThr: 2.583 ± 0.067
2.813PheVal: 2.813 ± 0.065
0.302PheTrp: 0.302 ± 0.021
2.533PheTyr: 2.533 ± 0.079
0.0PheXaa: 0.0 ± 0.0
Gly
3.666GlyAla: 3.666 ± 0.098
0.918GlyCys: 0.918 ± 0.04
3.314GlyAsp: 3.314 ± 0.072
3.379GlyGlu: 3.379 ± 0.068
3.106GlyPhe: 3.106 ± 0.072
3.582GlyGly: 3.582 ± 0.114
1.017GlyHis: 1.017 ± 0.04
5.695GlyIle: 5.695 ± 0.102
4.852GlyLys: 4.852 ± 0.099
5.166GlyLeu: 5.166 ± 0.098
1.644GlyMet: 1.644 ± 0.05
3.258GlyAsn: 3.258 ± 0.093
1.101GlyPro: 1.101 ± 0.043
1.228GlyGln: 1.228 ± 0.047
1.861GlyArg: 1.861 ± 0.056
3.348GlySer: 3.348 ± 0.088
3.446GlyThr: 3.446 ± 0.113
4.381GlyVal: 4.381 ± 0.084
0.503GlyTrp: 0.503 ± 0.028
3.675GlyTyr: 3.675 ± 0.089
0.0GlyXaa: 0.0 ± 0.0
His
0.835HisAla: 0.835 ± 0.035
0.208HisCys: 0.208 ± 0.018
0.926HisAsp: 0.926 ± 0.042
1.041HisGlu: 1.041 ± 0.041
0.822HisPhe: 0.822 ± 0.036
0.983HisGly: 0.983 ± 0.038
0.403HisHis: 0.403 ± 0.047
1.455HisIle: 1.455 ± 0.045
1.275HisLys: 1.275 ± 0.048
1.426HisLeu: 1.426 ± 0.047
0.465HisMet: 0.465 ± 0.028
0.923HisAsn: 0.923 ± 0.039
0.704HisPro: 0.704 ± 0.033
0.444HisGln: 0.444 ± 0.025
0.488HisArg: 0.488 ± 0.026
0.92HisSer: 0.92 ± 0.04
0.878HisThr: 0.878 ± 0.041
0.921HisVal: 0.921 ± 0.034
0.116HisTrp: 0.116 ± 0.014
0.866HisTyr: 0.866 ± 0.04
0.0HisXaa: 0.0 ± 0.0
Ile
5.073IleAla: 5.073 ± 0.098
1.178IleCys: 1.178 ± 0.045
5.861IleAsp: 5.861 ± 0.107
6.154IleGlu: 6.154 ± 0.122
3.558IlePhe: 3.558 ± 0.085
4.973IleGly: 4.973 ± 0.101
1.635IleHis: 1.635 ± 0.053
7.614IleIle: 7.614 ± 0.151
7.077IleLys: 7.077 ± 0.125
8.156IleLeu: 8.156 ± 0.153
1.846IleMet: 1.846 ± 0.06
4.932IleAsn: 4.932 ± 0.1
3.207IlePro: 3.207 ± 0.076
1.881IleGln: 1.881 ± 0.059
2.849IleArg: 2.849 ± 0.073
6.231IleSer: 6.231 ± 0.112
5.112IleThr: 5.112 ± 0.104
5.393IleVal: 5.393 ± 0.087
0.521IleTrp: 0.521 ± 0.032
4.153IleTyr: 4.153 ± 0.088
0.0IleXaa: 0.0 ± 0.0
Lys
4.973LysAla: 4.973 ± 0.108
0.858LysCys: 0.858 ± 0.032
6.243LysAsp: 6.243 ± 0.102
9.124LysGlu: 9.124 ± 0.148
2.648LysPhe: 2.648 ± 0.066
4.21LysGly: 4.21 ± 0.079
1.097LysHis: 1.097 ± 0.044
6.266LysIle: 6.266 ± 0.107
8.296LysLys: 8.296 ± 0.13
6.405LysLeu: 6.405 ± 0.11
2.512LysMet: 2.512 ± 0.062
5.882LysAsn: 5.882 ± 0.102
2.135LysPro: 2.135 ± 0.071
1.757LysGln: 1.757 ± 0.056
3.413LysArg: 3.413 ± 0.08
4.438LysSer: 4.438 ± 0.092
4.257LysThr: 4.257 ± 0.087
4.99LysVal: 4.99 ± 0.09
0.678LysTrp: 0.678 ± 0.034
4.754LysTyr: 4.754 ± 0.095
0.0LysXaa: 0.0 ± 0.0
Leu
5.97LeuAla: 5.97 ± 0.097
1.227LeuCys: 1.227 ± 0.051
6.447LeuAsp: 6.447 ± 0.111
6.358LeuGlu: 6.358 ± 0.103
4.275LeuPhe: 4.275 ± 0.099
5.768LeuGly: 5.768 ± 0.104
1.364LeuHis: 1.364 ± 0.049
6.923LeuIle: 6.923 ± 0.13
7.938LeuLys: 7.938 ± 0.117
7.805LeuLeu: 7.805 ± 0.143
2.275LeuMet: 2.275 ± 0.065
5.426LeuAsn: 5.426 ± 0.099
2.888LeuPro: 2.888 ± 0.063
1.669LeuGln: 1.669 ± 0.053
3.024LeuArg: 3.024 ± 0.078
6.608LeuSer: 6.608 ± 0.109
4.571LeuThr: 4.571 ± 0.106
5.543LeuVal: 5.543 ± 0.094
0.674LeuTrp: 0.674 ± 0.038
4.311LeuTyr: 4.311 ± 0.09
0.0LeuXaa: 0.0 ± 0.0
Met
1.742MetAla: 1.742 ± 0.054
0.258MetCys: 0.258 ± 0.02
1.917MetAsp: 1.917 ± 0.06
2.033MetGlu: 2.033 ± 0.059
0.953MetPhe: 0.953 ± 0.035
1.508MetGly: 1.508 ± 0.05
0.423MetHis: 0.423 ± 0.027
2.03MetIle: 2.03 ± 0.06
2.42MetLys: 2.42 ± 0.061
2.089MetLeu: 2.089 ± 0.061
0.648MetMet: 0.648 ± 0.038
1.706MetAsn: 1.706 ± 0.053
0.879MetPro: 0.879 ± 0.037
0.645MetGln: 0.645 ± 0.034
0.863MetArg: 0.863 ± 0.04
1.355MetSer: 1.355 ± 0.054
1.218MetThr: 1.218 ± 0.044
1.713MetVal: 1.713 ± 0.058
0.184MetTrp: 0.184 ± 0.017
0.947MetTyr: 0.947 ± 0.041
0.0MetXaa: 0.0 ± 0.0
Asn
3.275AsnAla: 3.275 ± 0.079
0.701AsnCys: 0.701 ± 0.042
3.538AsnAsp: 3.538 ± 0.086
4.213AsnGlu: 4.213 ± 0.082
2.206AsnPhe: 2.206 ± 0.066
4.0AsnGly: 4.0 ± 0.104
1.218AsnHis: 1.218 ± 0.045
5.08AsnIle: 5.08 ± 0.111
5.13AsnLys: 5.13 ± 0.123
5.083AsnLeu: 5.083 ± 0.093
1.489AsnMet: 1.489 ± 0.051
3.804AsnAsn: 3.804 ± 0.112
2.405AsnPro: 2.405 ± 0.062
1.843AsnGln: 1.843 ± 0.061
1.86AsnArg: 1.86 ± 0.055
3.567AsnSer: 3.567 ± 0.09
3.11AsnThr: 3.11 ± 0.08
3.754AsnVal: 3.754 ± 0.088
0.465AsnTrp: 0.465 ± 0.028
3.352AsnTyr: 3.352 ± 0.092
0.0AsnXaa: 0.0 ± 0.0
Pro
1.337ProAla: 1.337 ± 0.049
0.298ProCys: 0.298 ± 0.021
1.579ProAsp: 1.579 ± 0.046
2.139ProGlu: 2.139 ± 0.055
1.577ProPhe: 1.577 ± 0.053
1.42ProGly: 1.42 ± 0.054
0.462ProHis: 0.462 ± 0.027
2.544ProIle: 2.544 ± 0.064
2.488ProLys: 2.488 ± 0.07
2.651ProLeu: 2.651 ± 0.067
0.702ProMet: 0.702 ± 0.034
1.761ProAsn: 1.761 ± 0.054
0.344ProPro: 0.344 ± 0.025
0.654ProGln: 0.654 ± 0.034
0.755ProArg: 0.755 ± 0.038
1.867ProSer: 1.867 ± 0.056
1.718ProThr: 1.718 ± 0.052
1.848ProVal: 1.848 ± 0.067
0.219ProTrp: 0.219 ± 0.02
1.638ProTyr: 1.638 ± 0.05
0.0ProXaa: 0.0 ± 0.0
Gln
1.6GlnAla: 1.6 ± 0.051
0.237GlnCys: 0.237 ± 0.019
1.296GlnAsp: 1.296 ± 0.049
1.687GlnGlu: 1.687 ± 0.055
0.983GlnPhe: 0.983 ± 0.039
1.296GlnGly: 1.296 ± 0.045
0.245GlnHis: 0.245 ± 0.019
1.996GlnIle: 1.996 ± 0.055
1.925GlnLys: 1.925 ± 0.065
1.65GlnLeu: 1.65 ± 0.051
0.789GlnMet: 0.789 ± 0.036
1.322GlnAsn: 1.322 ± 0.049
0.45GlnPro: 0.45 ± 0.025
0.514GlnGln: 0.514 ± 0.031
0.875GlnArg: 0.875 ± 0.037
1.13GlnSer: 1.13 ± 0.048
1.189GlnThr: 1.189 ± 0.052
1.417GlnVal: 1.417 ± 0.048
0.165GlnTrp: 0.165 ± 0.016
1.106GlnTyr: 1.106 ± 0.045
0.0GlnXaa: 0.0 ± 0.0
Arg
1.773ArgAla: 1.773 ± 0.06
0.415ArgCys: 0.415 ± 0.026
1.848ArgAsp: 1.848 ± 0.06
2.192ArgGlu: 2.192 ± 0.061
1.592ArgPhe: 1.592 ± 0.057
1.799ArgGly: 1.799 ± 0.055
0.545ArgHis: 0.545 ± 0.03
3.222ArgIle: 3.222 ± 0.075
2.764ArgLys: 2.764 ± 0.076
2.956ArgLeu: 2.956 ± 0.074
1.021ArgMet: 1.021 ± 0.037
1.959ArgAsn: 1.959 ± 0.054
0.87ArgPro: 0.87 ± 0.042
0.837ArgGln: 0.837 ± 0.043
1.456ArgArg: 1.456 ± 0.056
1.588ArgSer: 1.588 ± 0.048
1.422ArgThr: 1.422 ± 0.045
2.212ArgVal: 2.212 ± 0.071
0.221ArgTrp: 0.221 ± 0.019
1.627ArgTyr: 1.627 ± 0.051
0.0ArgXaa: 0.0 ± 0.0
Ser
2.95SerAla: 2.95 ± 0.081
0.823SerCys: 0.823 ± 0.04
3.722SerAsp: 3.722 ± 0.075
3.446SerGlu: 3.446 ± 0.071
3.678SerPhe: 3.678 ± 0.074
3.974SerGly: 3.974 ± 0.109
1.079SerHis: 1.079 ± 0.04
6.357SerIle: 6.357 ± 0.122
5.382SerLys: 5.382 ± 0.096
6.79SerLeu: 6.79 ± 0.118
1.553SerMet: 1.553 ± 0.052
3.971SerAsn: 3.971 ± 0.108
1.423SerPro: 1.423 ± 0.047
1.378SerGln: 1.378 ± 0.048
1.769SerArg: 1.769 ± 0.053
4.615SerSer: 4.615 ± 0.128
3.357SerThr: 3.357 ± 0.083
3.583SerVal: 3.583 ± 0.084
0.523SerTrp: 0.523 ± 0.032
3.884SerTyr: 3.884 ± 0.096
0.0SerXaa: 0.0 ± 0.0
Thr
2.743ThrAla: 2.743 ± 0.085
0.601ThrCys: 0.601 ± 0.037
2.647ThrAsp: 2.647 ± 0.064
2.984ThrGlu: 2.984 ± 0.071
2.651ThrPhe: 2.651 ± 0.074
3.364ThrGly: 3.364 ± 0.1
0.872ThrHis: 0.872 ± 0.037
5.455ThrIle: 5.455 ± 0.118
4.375ThrLys: 4.375 ± 0.09
5.207ThrLeu: 5.207 ± 0.102
1.119ThrMet: 1.119 ± 0.039
3.15ThrAsn: 3.15 ± 0.084
1.852ThrPro: 1.852 ± 0.058
1.082ThrGln: 1.082 ± 0.045
1.423ThrArg: 1.423 ± 0.047
3.44ThrSer: 3.44 ± 0.107
3.432ThrThr: 3.432 ± 0.122
3.435ThrVal: 3.435 ± 0.101
0.435ThrTrp: 0.435 ± 0.028
2.949ThrTyr: 2.949 ± 0.086
0.0ThrXaa: 0.0 ± 0.0
Val
3.715ValAla: 3.715 ± 0.093
0.98ValCys: 0.98 ± 0.038
3.905ValAsp: 3.905 ± 0.084
4.144ValGlu: 4.144 ± 0.083
3.163ValPhe: 3.163 ± 0.064
3.568ValGly: 3.568 ± 0.092
0.866ValHis: 0.866 ± 0.038
5.293ValIle: 5.293 ± 0.103
4.81ValLys: 4.81 ± 0.083
6.117ValLeu: 6.117 ± 0.107
1.388ValMet: 1.388 ± 0.049
3.236ValAsn: 3.236 ± 0.082
1.724ValPro: 1.724 ± 0.062
1.128ValGln: 1.128 ± 0.04
1.934ValArg: 1.934 ± 0.054
4.911ValSer: 4.911 ± 0.108
3.597ValThr: 3.597 ± 0.098
4.222ValVal: 4.222 ± 0.099
0.456ValTrp: 0.456 ± 0.027
2.993ValTyr: 2.993 ± 0.076
0.0ValXaa: 0.0 ± 0.0
Trp
0.414TrpAla: 0.414 ± 0.03
0.106TrpCys: 0.106 ± 0.013
0.465TrpAsp: 0.465 ± 0.03
0.408TrpGlu: 0.408 ± 0.023
0.42TrpPhe: 0.42 ± 0.027
0.441TrpGly: 0.441 ± 0.03
0.131TrpHis: 0.131 ± 0.014
0.588TrpIle: 0.588 ± 0.029
0.554TrpLys: 0.554 ± 0.028
0.725TrpLeu: 0.725 ± 0.04
0.225TrpMet: 0.225 ± 0.018
0.524TrpAsn: 0.524 ± 0.026
0.231TrpPro: 0.231 ± 0.026
0.207TrpGln: 0.207 ± 0.019
0.237TrpArg: 0.237 ± 0.021
0.429TrpSer: 0.429 ± 0.029
0.287TrpThr: 0.287 ± 0.022
0.45TrpVal: 0.45 ± 0.024
0.136TrpTrp: 0.136 ± 0.015
0.429TrpTyr: 0.429 ± 0.025
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.903TyrAla: 2.903 ± 0.076
0.687TyrCys: 0.687 ± 0.03
3.858TyrAsp: 3.858 ± 0.111
3.496TyrGlu: 3.496 ± 0.085
2.622TyrPhe: 2.622 ± 0.079
3.109TyrGly: 3.109 ± 0.073
0.986TyrHis: 0.986 ± 0.042
4.048TyrIle: 4.048 ± 0.084
4.334TyrLys: 4.334 ± 0.091
4.996TyrLeu: 4.996 ± 0.094
1.213TyrMet: 1.213 ± 0.047
3.473TyrAsn: 3.473 ± 0.09
1.61TyrPro: 1.61 ± 0.048
1.591TyrGln: 1.591 ± 0.052
1.674TyrArg: 1.674 ± 0.05
3.819TyrSer: 3.819 ± 0.101
3.116TyrThr: 3.116 ± 0.097
3.115TyrVal: 3.115 ± 0.08
0.358TyrTrp: 0.358 ± 0.024
3.351TyrTyr: 3.351 ± 0.104
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 1953 proteins (661975 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski