Amino acid dipepetide frequency for Vagococcus silagei

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
4.403AlaAla: 4.403 ± 0.108
0.482AlaCys: 0.482 ± 0.027
3.382AlaAsp: 3.382 ± 0.072
4.532AlaGlu: 4.532 ± 0.084
2.912AlaPhe: 2.912 ± 0.065
4.245AlaGly: 4.245 ± 0.084
1.159AlaHis: 1.159 ± 0.041
5.739AlaIle: 5.739 ± 0.106
4.977AlaLys: 4.977 ± 0.096
6.595AlaLeu: 6.595 ± 0.105
1.797AlaMet: 1.797 ± 0.055
2.94AlaAsn: 2.94 ± 0.069
1.899AlaPro: 1.899 ± 0.057
2.533AlaGln: 2.533 ± 0.062
2.286AlaArg: 2.286 ± 0.065
3.966AlaSer: 3.966 ± 0.091
4.0AlaThr: 4.0 ± 0.092
4.488AlaVal: 4.488 ± 0.104
0.478AlaTrp: 0.478 ± 0.028
2.242AlaTyr: 2.242 ± 0.062
0.001AlaXaa: 0.001 ± 0.001
Cys
0.348CysAla: 0.348 ± 0.024
0.096CysCys: 0.096 ± 0.01
0.356CysAsp: 0.356 ± 0.021
0.43CysGlu: 0.43 ± 0.025
0.349CysPhe: 0.349 ± 0.021
0.545CysGly: 0.545 ± 0.033
0.177CysHis: 0.177 ± 0.017
0.442CysIle: 0.442 ± 0.026
0.213CysLys: 0.213 ± 0.017
0.765CysLeu: 0.765 ± 0.038
0.135CysMet: 0.135 ± 0.016
0.199CysAsn: 0.199 ± 0.016
0.253CysPro: 0.253 ± 0.019
0.356CysGln: 0.356 ± 0.025
0.257CysArg: 0.257 ± 0.018
0.415CysSer: 0.415 ± 0.025
0.282CysThr: 0.282 ± 0.019
0.416CysVal: 0.416 ± 0.023
0.047CysTrp: 0.047 ± 0.009
0.249CysTyr: 0.249 ± 0.018
0.0CysXaa: 0.0 ± 0.0
Asp
3.58AspAla: 3.58 ± 0.075
0.35AspCys: 0.35 ± 0.025
2.971AspAsp: 2.971 ± 0.079
4.612AspGlu: 4.612 ± 0.08
2.922AspPhe: 2.922 ± 0.056
3.335AspGly: 3.335 ± 0.09
0.986AspHis: 0.986 ± 0.039
4.282AspIle: 4.282 ± 0.075
3.73AspLys: 3.73 ± 0.094
5.455AspLeu: 5.455 ± 0.089
1.396AspMet: 1.396 ± 0.049
2.265AspAsn: 2.265 ± 0.061
1.769AspPro: 1.769 ± 0.057
2.28AspGln: 2.28 ± 0.058
1.861AspArg: 1.861 ± 0.05
2.984AspSer: 2.984 ± 0.068
2.889AspThr: 2.889 ± 0.065
4.118AspVal: 4.118 ± 0.079
0.585AspTrp: 0.585 ± 0.034
2.559AspTyr: 2.559 ± 0.063
0.0AspXaa: 0.0 ± 0.0
Glu
5.331GluAla: 5.331 ± 0.102
0.383GluCys: 0.383 ± 0.024
3.687GluAsp: 3.687 ± 0.072
6.169GluGlu: 6.169 ± 0.112
2.669GluPhe: 2.669 ± 0.069
3.808GluGly: 3.808 ± 0.078
1.348GluHis: 1.348 ± 0.039
5.847GluIle: 5.847 ± 0.102
6.804GluLys: 6.804 ± 0.119
7.58GluLeu: 7.58 ± 0.118
2.379GluMet: 2.379 ± 0.055
4.036GluAsn: 4.036 ± 0.086
1.805GluPro: 1.805 ± 0.052
3.194GluGln: 3.194 ± 0.088
2.923GluArg: 2.923 ± 0.069
3.818GluSer: 3.818 ± 0.07
4.553GluThr: 4.553 ± 0.093
5.187GluVal: 5.187 ± 0.102
0.673GluTrp: 0.673 ± 0.035
2.227GluTyr: 2.227 ± 0.063
0.0GluXaa: 0.0 ± 0.0
Phe
2.715PheAla: 2.715 ± 0.081
0.319PheCys: 0.319 ± 0.021
2.9PheAsp: 2.9 ± 0.066
3.256PheGlu: 3.256 ± 0.078
2.478PhePhe: 2.478 ± 0.08
3.21PheGly: 3.21 ± 0.077
0.717PheHis: 0.717 ± 0.031
3.835PheIle: 3.835 ± 0.102
3.057PheLys: 3.057 ± 0.072
4.432PheLeu: 4.432 ± 0.103
1.173PheMet: 1.173 ± 0.039
2.388PheAsn: 2.388 ± 0.056
1.427PhePro: 1.427 ± 0.05
1.383PheGln: 1.383 ± 0.041
1.376PheArg: 1.376 ± 0.04
3.515PheSer: 3.515 ± 0.076
2.555PheThr: 2.555 ± 0.064
3.228PheVal: 3.228 ± 0.068
0.412PheTrp: 0.412 ± 0.025
1.903PheTyr: 1.903 ± 0.059
0.003PheXaa: 0.003 ± 0.002
Gly
4.072GlyAla: 4.072 ± 0.097
0.463GlyCys: 0.463 ± 0.028
3.007GlyAsp: 3.007 ± 0.075
3.984GlyGlu: 3.984 ± 0.079
3.138GlyPhe: 3.138 ± 0.068
4.084GlyGly: 4.084 ± 0.096
1.166GlyHis: 1.166 ± 0.038
5.293GlyIle: 5.293 ± 0.097
4.694GlyLys: 4.694 ± 0.097
6.12GlyLeu: 6.12 ± 0.111
1.881GlyMet: 1.881 ± 0.059
2.644GlyAsn: 2.644 ± 0.068
1.382GlyPro: 1.382 ± 0.045
2.449GlyGln: 2.449 ± 0.055
2.271GlyArg: 2.271 ± 0.069
3.771GlySer: 3.771 ± 0.088
3.824GlyThr: 3.824 ± 0.082
4.667GlyVal: 4.667 ± 0.097
0.51GlyTrp: 0.51 ± 0.026
2.592GlyTyr: 2.592 ± 0.076
0.0GlyXaa: 0.0 ± 0.0
His
1.088HisAla: 1.088 ± 0.039
0.15HisCys: 0.15 ± 0.016
1.076HisAsp: 1.076 ± 0.041
1.15HisGlu: 1.15 ± 0.042
1.007HisPhe: 1.007 ± 0.042
1.143HisGly: 1.143 ± 0.036
0.545HisHis: 0.545 ± 0.026
1.143HisIle: 1.143 ± 0.044
0.837HisLys: 0.837 ± 0.034
2.048HisLeu: 2.048 ± 0.06
0.404HisMet: 0.404 ± 0.022
0.672HisAsn: 0.672 ± 0.029
0.903HisPro: 0.903 ± 0.038
0.973HisGln: 0.973 ± 0.042
0.721HisArg: 0.721 ± 0.036
1.019HisSer: 1.019 ± 0.043
0.909HisThr: 0.909 ± 0.035
1.111HisVal: 1.111 ± 0.04
0.155HisTrp: 0.155 ± 0.013
0.887HisTyr: 0.887 ± 0.033
0.0HisXaa: 0.0 ± 0.0
Ile
5.429IleAla: 5.429 ± 0.106
0.6IleCys: 0.6 ± 0.028
4.724IleAsp: 4.724 ± 0.078
5.88IleGlu: 5.88 ± 0.101
3.624IlePhe: 3.624 ± 0.094
5.349IleGly: 5.349 ± 0.101
1.346IleHis: 1.346 ± 0.042
6.164IleIle: 6.164 ± 0.121
5.521IleLys: 5.521 ± 0.095
7.616IleLeu: 7.616 ± 0.131
1.874IleMet: 1.874 ± 0.06
3.857IleAsn: 3.857 ± 0.072
3.061IlePro: 3.061 ± 0.064
3.114IleGln: 3.114 ± 0.078
2.693IleArg: 2.693 ± 0.064
5.417IleSer: 5.417 ± 0.088
4.234IleThr: 4.234 ± 0.079
5.547IleVal: 5.547 ± 0.105
0.526IleTrp: 0.526 ± 0.029
2.638IleTyr: 2.638 ± 0.067
0.0IleXaa: 0.0 ± 0.0
Lys
4.665LysAla: 4.665 ± 0.107
0.29LysCys: 0.29 ± 0.023
4.285LysAsp: 4.285 ± 0.088
7.038LysGlu: 7.038 ± 0.126
2.341LysPhe: 2.341 ± 0.065
3.943LysGly: 3.943 ± 0.082
1.212LysHis: 1.212 ± 0.037
5.922LysIle: 5.922 ± 0.104
6.992LysLys: 6.992 ± 0.116
6.068LysLeu: 6.068 ± 0.104
2.569LysMet: 2.569 ± 0.057
4.381LysAsn: 4.381 ± 0.089
2.212LysPro: 2.212 ± 0.062
3.379LysGln: 3.379 ± 0.075
2.967LysArg: 2.967 ± 0.059
3.881LysSer: 3.881 ± 0.078
4.374LysThr: 4.374 ± 0.094
4.889LysVal: 4.889 ± 0.093
0.653LysTrp: 0.653 ± 0.029
2.518LysTyr: 2.518 ± 0.07
0.0LysXaa: 0.0 ± 0.0
Leu
7.214LeuAla: 7.214 ± 0.106
0.606LeuCys: 0.606 ± 0.03
5.463LeuAsp: 5.463 ± 0.09
6.961LeuGlu: 6.961 ± 0.137
4.896LeuPhe: 4.896 ± 0.117
6.022LeuGly: 6.022 ± 0.105
1.397LeuHis: 1.397 ± 0.05
7.87LeuIle: 7.87 ± 0.146
7.234LeuLys: 7.234 ± 0.106
9.682LeuLeu: 9.682 ± 0.184
2.609LeuMet: 2.609 ± 0.057
5.244LeuAsn: 5.244 ± 0.089
3.757LeuPro: 3.757 ± 0.076
3.149LeuGln: 3.149 ± 0.078
3.087LeuArg: 3.087 ± 0.068
7.095LeuSer: 7.095 ± 0.116
6.65LeuThr: 6.65 ± 0.102
6.566LeuVal: 6.566 ± 0.104
0.705LeuTrp: 0.705 ± 0.037
2.974LeuTyr: 2.974 ± 0.066
0.0LeuXaa: 0.0 ± 0.0
Met
1.791MetAla: 1.791 ± 0.053
0.151MetCys: 0.151 ± 0.015
1.378MetAsp: 1.378 ± 0.042
1.596MetGlu: 1.596 ± 0.051
1.015MetPhe: 1.015 ± 0.038
1.635MetGly: 1.635 ± 0.051
0.359MetHis: 0.359 ± 0.02
2.408MetIle: 2.408 ± 0.07
2.485MetLys: 2.485 ± 0.054
2.484MetLeu: 2.484 ± 0.061
0.914MetMet: 0.914 ± 0.043
1.58MetAsn: 1.58 ± 0.052
0.933MetPro: 0.933 ± 0.034
0.87MetGln: 0.87 ± 0.034
0.985MetArg: 0.985 ± 0.035
1.877MetSer: 1.877 ± 0.061
2.055MetThr: 2.055 ± 0.053
1.695MetVal: 1.695 ± 0.049
0.173MetTrp: 0.173 ± 0.017
0.679MetTyr: 0.679 ± 0.028
0.0MetXaa: 0.0 ± 0.0
Asn
2.823AsnAla: 2.823 ± 0.067
0.31AsnCys: 0.31 ± 0.02
2.716AsnAsp: 2.716 ± 0.074
3.557AsnGlu: 3.557 ± 0.076
2.201AsnPhe: 2.201 ± 0.056
3.206AsnGly: 3.206 ± 0.09
1.106AsnHis: 1.106 ± 0.043
3.585AsnIle: 3.585 ± 0.069
3.506AsnLys: 3.506 ± 0.076
4.709AsnLeu: 4.709 ± 0.076
1.153AsnMet: 1.153 ± 0.044
2.394AsnAsn: 2.394 ± 0.079
2.048AsnPro: 2.048 ± 0.048
2.996AsnGln: 2.996 ± 0.076
1.981AsnArg: 1.981 ± 0.049
2.558AsnSer: 2.558 ± 0.063
2.448AsnThr: 2.448 ± 0.065
3.183AsnVal: 3.183 ± 0.065
0.501AsnTrp: 0.501 ± 0.026
2.128AsnTyr: 2.128 ± 0.055
0.0AsnXaa: 0.0 ± 0.0
Pro
1.861ProAla: 1.861 ± 0.056
0.147ProCys: 0.147 ± 0.015
1.812ProAsp: 1.812 ± 0.054
2.944ProGlu: 2.944 ± 0.071
1.648ProPhe: 1.648 ± 0.053
1.889ProGly: 1.889 ± 0.057
0.609ProHis: 0.609 ± 0.024
2.673ProIle: 2.673 ± 0.06
2.522ProLys: 2.522 ± 0.063
3.151ProLeu: 3.151 ± 0.069
0.793ProMet: 0.793 ± 0.037
1.839ProAsn: 1.839 ± 0.053
0.598ProPro: 0.598 ± 0.036
1.254ProGln: 1.254 ± 0.042
0.931ProArg: 0.931 ± 0.033
1.944ProSer: 1.944 ± 0.047
2.23ProThr: 2.23 ± 0.059
2.514ProVal: 2.514 ± 0.059
0.269ProTrp: 0.269 ± 0.02
1.212ProTyr: 1.212 ± 0.041
0.0ProXaa: 0.0 ± 0.0
Gln
2.97GlnAla: 2.97 ± 0.08
0.165GlnCys: 0.165 ± 0.016
2.107GlnAsp: 2.107 ± 0.051
3.293GlnGlu: 3.293 ± 0.09
1.742GlnPhe: 1.742 ± 0.056
2.059GlnGly: 2.059 ± 0.057
0.747GlnHis: 0.747 ± 0.034
3.013GlnIle: 3.013 ± 0.065
3.367GlnLys: 3.367 ± 0.081
4.378GlnLeu: 4.378 ± 0.102
1.234GlnMet: 1.234 ± 0.043
2.1GlnAsn: 2.1 ± 0.07
1.344GlnPro: 1.344 ± 0.044
1.892GlnGln: 1.892 ± 0.075
1.459GlnArg: 1.459 ± 0.047
2.315GlnSer: 2.315 ± 0.058
2.66GlnThr: 2.66 ± 0.062
2.742GlnVal: 2.742 ± 0.059
0.349GlnTrp: 0.349 ± 0.021
1.37GlnTyr: 1.37 ± 0.045
0.0GlnXaa: 0.0 ± 0.0
Arg
2.056ArgAla: 2.056 ± 0.052
0.213ArgCys: 0.213 ± 0.02
1.934ArgAsp: 1.934 ± 0.055
2.846ArgGlu: 2.846 ± 0.068
1.694ArgPhe: 1.694 ± 0.055
1.959ArgGly: 1.959 ± 0.063
0.692ArgHis: 0.692 ± 0.031
2.679ArgIle: 2.679 ± 0.061
2.86ArgLys: 2.86 ± 0.076
3.688ArgLeu: 3.688 ± 0.072
1.092ArgMet: 1.092 ± 0.041
1.613ArgAsn: 1.613 ± 0.05
1.153ArgPro: 1.153 ± 0.045
1.683ArgGln: 1.683 ± 0.056
1.609ArgArg: 1.609 ± 0.053
1.786ArgSer: 1.786 ± 0.053
1.815ArgThr: 1.815 ± 0.048
2.613ArgVal: 2.613 ± 0.06
0.276ArgTrp: 0.276 ± 0.02
1.363ArgTyr: 1.363 ± 0.046
0.0ArgXaa: 0.0 ± 0.0
Ser
3.546SerAla: 3.546 ± 0.074
0.35SerCys: 0.35 ± 0.027
3.378SerAsp: 3.378 ± 0.07
4.461SerGlu: 4.461 ± 0.085
3.239SerPhe: 3.239 ± 0.07
4.397SerGly: 4.397 ± 0.078
1.169SerHis: 1.169 ± 0.04
5.051SerIle: 5.051 ± 0.08
4.264SerLys: 4.264 ± 0.081
6.439SerLeu: 6.439 ± 0.114
1.569SerMet: 1.569 ± 0.045
2.903SerAsn: 2.903 ± 0.076
1.805SerPro: 1.805 ± 0.05
2.555SerGln: 2.555 ± 0.071
2.158SerArg: 2.158 ± 0.056
3.84SerSer: 3.84 ± 0.085
3.384SerThr: 3.384 ± 0.08
4.088SerVal: 4.088 ± 0.08
0.523SerTrp: 0.523 ± 0.026
2.271SerTyr: 2.271 ± 0.065
0.0SerXaa: 0.0 ± 0.0
Thr
3.588ThrAla: 3.588 ± 0.087
0.342ThrCys: 0.342 ± 0.022
3.27ThrAsp: 3.27 ± 0.064
4.014ThrGlu: 4.014 ± 0.076
2.785ThrPhe: 2.785 ± 0.068
4.066ThrGly: 4.066 ± 0.087
1.126ThrHis: 1.126 ± 0.038
5.024ThrIle: 5.024 ± 0.091
4.315ThrLys: 4.315 ± 0.08
6.071ThrLeu: 6.071 ± 0.096
1.403ThrMet: 1.403 ± 0.043
2.785ThrAsn: 2.785 ± 0.074
2.44ThrPro: 2.44 ± 0.064
2.241ThrGln: 2.241 ± 0.067
1.756ThrArg: 1.756 ± 0.044
3.605ThrSer: 3.605 ± 0.08
3.768ThrThr: 3.768 ± 0.103
4.209ThrVal: 4.209 ± 0.091
0.46ThrTrp: 0.46 ± 0.027
2.147ThrTyr: 2.147 ± 0.058
0.0ThrXaa: 0.0 ± 0.0
Val
5.057ValAla: 5.057 ± 0.097
0.533ValCys: 0.533 ± 0.028
3.855ValAsp: 3.855 ± 0.086
4.738ValGlu: 4.738 ± 0.091
3.01ValPhe: 3.01 ± 0.061
4.47ValGly: 4.47 ± 0.085
0.971ValHis: 0.971 ± 0.035
5.452ValIle: 5.452 ± 0.095
4.847ValLys: 4.847 ± 0.091
6.763ValLeu: 6.763 ± 0.101
1.772ValMet: 1.772 ± 0.051
3.297ValAsn: 3.297 ± 0.069
2.486ValPro: 2.486 ± 0.063
2.186ValGln: 2.186 ± 0.061
2.286ValArg: 2.286 ± 0.059
4.881ValSer: 4.881 ± 0.069
4.496ValThr: 4.496 ± 0.079
5.018ValVal: 5.018 ± 0.097
0.484ValTrp: 0.484 ± 0.032
2.263ValTyr: 2.263 ± 0.059
0.0ValXaa: 0.0 ± 0.0
Trp
0.371TrpAla: 0.371 ± 0.023
0.059TrpCys: 0.059 ± 0.008
0.457TrpAsp: 0.457 ± 0.027
0.56TrpGlu: 0.56 ± 0.031
0.408TrpPhe: 0.408 ± 0.025
0.468TrpGly: 0.468 ± 0.028
0.174TrpHis: 0.174 ± 0.016
0.631TrpIle: 0.631 ± 0.032
0.522TrpLys: 0.522 ± 0.028
0.984TrpLeu: 0.984 ± 0.039
0.251TrpMet: 0.251 ± 0.02
0.437TrpAsn: 0.437 ± 0.026
0.173TrpPro: 0.173 ± 0.013
0.492TrpGln: 0.492 ± 0.029
0.357TrpArg: 0.357 ± 0.022
0.525TrpSer: 0.525 ± 0.025
0.448TrpThr: 0.448 ± 0.023
0.496TrpVal: 0.496 ± 0.026
0.081TrpTrp: 0.081 ± 0.011
0.321TrpTyr: 0.321 ± 0.022
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.15TyrAla: 2.15 ± 0.056
0.319TyrCys: 0.319 ± 0.021
2.175TyrAsp: 2.175 ± 0.057
2.403TyrGlu: 2.403 ± 0.063
2.205TyrPhe: 2.205 ± 0.062
2.176TyrGly: 2.176 ± 0.054
0.933TyrHis: 0.933 ± 0.035
2.16TyrIle: 2.16 ± 0.06
1.831TyrLys: 1.831 ± 0.049
4.151TyrLeu: 4.151 ± 0.088
0.665TyrMet: 0.665 ± 0.028
1.536TyrAsn: 1.536 ± 0.046
1.394TyrPro: 1.394 ± 0.047
2.324TyrGln: 2.324 ± 0.065
1.659TyrArg: 1.659 ± 0.05
2.179TyrSer: 2.179 ± 0.066
1.839TyrThr: 1.839 ± 0.056
2.087TyrVal: 2.087 ± 0.056
0.356TyrTrp: 0.356 ± 0.022
1.681TyrTyr: 1.681 ± 0.057
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.001XaaLeu: 0.001 ± 0.001
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.001XaaGln: 0.001 ± 0.001
0.0XaaArg: 0.0 ± 0.0
0.001XaaSer: 0.001 ± 0.001
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2379 proteins (727940 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski