Amino acid dipepetide frequency for Bacteroidaceae bacterium

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
5.687AlaAla: 5.687 ± 0.098
1.065AlaCys: 1.065 ± 0.032
4.25AlaAsp: 4.25 ± 0.062
4.721AlaGlu: 4.721 ± 0.069
3.087AlaPhe: 3.087 ± 0.053
5.145AlaGly: 5.145 ± 0.075
1.303AlaHis: 1.303 ± 0.034
4.614AlaIle: 4.614 ± 0.074
4.006AlaLys: 4.006 ± 0.066
6.42AlaLeu: 6.42 ± 0.093
1.988AlaMet: 1.988 ± 0.043
3.122AlaAsn: 3.122 ± 0.058
2.307AlaPro: 2.307 ± 0.041
2.568AlaGln: 2.568 ± 0.045
3.098AlaArg: 3.098 ± 0.063
4.188AlaSer: 4.188 ± 0.069
3.709AlaThr: 3.709 ± 0.061
4.77AlaVal: 4.77 ± 0.072
0.87AlaTrp: 0.87 ± 0.029
2.992AlaTyr: 2.992 ± 0.051
0.0AlaXaa: 0.0 ± 0.0
Cys
0.837CysAla: 0.837 ± 0.024
0.24CysCys: 0.24 ± 0.016
0.655CysAsp: 0.655 ± 0.023
0.707CysGlu: 0.707 ± 0.023
0.697CysPhe: 0.697 ± 0.025
1.111CysGly: 1.111 ± 0.033
0.326CysHis: 0.326 ± 0.016
0.95CysIle: 0.95 ± 0.029
0.759CysLys: 0.759 ± 0.023
1.213CysLeu: 1.213 ± 0.035
0.429CysMet: 0.429 ± 0.019
0.606CysAsn: 0.606 ± 0.026
0.56CysPro: 0.56 ± 0.023
0.362CysGln: 0.362 ± 0.018
0.696CysArg: 0.696 ± 0.026
0.818CysSer: 0.818 ± 0.027
0.731CysThr: 0.731 ± 0.025
0.774CysVal: 0.774 ± 0.026
0.163CysTrp: 0.163 ± 0.011
0.576CysTyr: 0.576 ± 0.02
0.0CysXaa: 0.0 ± 0.0
Asp
3.806AspAla: 3.806 ± 0.058
0.655AspCys: 0.655 ± 0.023
2.583AspAsp: 2.583 ± 0.05
3.91AspGlu: 3.91 ± 0.059
2.967AspPhe: 2.967 ± 0.054
4.181AspGly: 4.181 ± 0.07
0.872AspHis: 0.872 ± 0.026
4.037AspIle: 4.037 ± 0.064
4.134AspLys: 4.134 ± 0.06
4.446AspLeu: 4.446 ± 0.062
1.698AspMet: 1.698 ± 0.039
2.802AspAsn: 2.802 ± 0.051
1.814AspPro: 1.814 ± 0.051
1.205AspGln: 1.205 ± 0.035
2.478AspArg: 2.478 ± 0.046
2.995AspSer: 2.995 ± 0.062
2.744AspThr: 2.744 ± 0.052
3.481AspVal: 3.481 ± 0.055
0.923AspTrp: 0.923 ± 0.029
3.009AspTyr: 3.009 ± 0.057
0.0AspXaa: 0.0 ± 0.0
Glu
4.839GluAla: 4.839 ± 0.071
0.701GluCys: 0.701 ± 0.023
3.277GluAsp: 3.277 ± 0.059
5.237GluGlu: 5.237 ± 0.091
2.518GluPhe: 2.518 ± 0.05
4.195GluGly: 4.195 ± 0.065
1.292GluHis: 1.292 ± 0.036
4.605GluIle: 4.605 ± 0.07
5.421GluLys: 5.421 ± 0.069
6.198GluLeu: 6.198 ± 0.086
2.092GluMet: 2.092 ± 0.039
3.686GluAsn: 3.686 ± 0.064
1.752GluPro: 1.752 ± 0.041
2.704GluGln: 2.704 ± 0.051
3.328GluArg: 3.328 ± 0.056
3.114GluSer: 3.114 ± 0.054
3.408GluThr: 3.408 ± 0.053
4.347GluVal: 4.347 ± 0.067
0.945GluTrp: 0.945 ± 0.029
2.867GluTyr: 2.867 ± 0.049
0.0GluXaa: 0.0 ± 0.0
Phe
2.979PheAla: 2.979 ± 0.063
0.729PheCys: 0.729 ± 0.025
2.768PheAsp: 2.768 ± 0.053
2.506PheGlu: 2.506 ± 0.042
2.249PhePhe: 2.249 ± 0.056
3.209PheGly: 3.209 ± 0.064
0.996PheHis: 0.996 ± 0.033
3.247PheIle: 3.247 ± 0.055
2.54PheLys: 2.54 ± 0.047
4.057PheLeu: 4.057 ± 0.068
1.342PheMet: 1.342 ± 0.036
2.432PheAsn: 2.432 ± 0.053
1.796PhePro: 1.796 ± 0.046
1.325PheGln: 1.325 ± 0.036
2.168PheArg: 2.168 ± 0.04
3.277PheSer: 3.277 ± 0.055
2.731PheThr: 2.731 ± 0.044
2.822PheVal: 2.822 ± 0.05
0.582PheTrp: 0.582 ± 0.025
2.087PheTyr: 2.087 ± 0.041
0.0PheXaa: 0.0 ± 0.0
Gly
4.266GlyAla: 4.266 ± 0.069
0.99GlyCys: 0.99 ± 0.032
3.388GlyAsp: 3.388 ± 0.065
4.231GlyGlu: 4.231 ± 0.064
3.121GlyPhe: 3.121 ± 0.052
4.765GlyGly: 4.765 ± 0.073
1.321GlyHis: 1.321 ± 0.031
5.273GlyIle: 5.273 ± 0.07
5.613GlyLys: 5.613 ± 0.076
5.726GlyLeu: 5.726 ± 0.07
2.341GlyMet: 2.341 ± 0.046
3.786GlyAsn: 3.786 ± 0.065
1.277GlyPro: 1.277 ± 0.034
2.087GlyGln: 2.087 ± 0.04
2.974GlyArg: 2.974 ± 0.053
3.855GlySer: 3.855 ± 0.063
4.211GlyThr: 4.211 ± 0.066
4.759GlyVal: 4.759 ± 0.073
1.05GlyTrp: 1.05 ± 0.031
3.46GlyTyr: 3.46 ± 0.063
0.0GlyXaa: 0.0 ± 0.0
His
1.202HisAla: 1.202 ± 0.034
0.326HisCys: 0.326 ± 0.02
1.017HisAsp: 1.017 ± 0.031
1.073HisGlu: 1.073 ± 0.034
1.085HisPhe: 1.085 ± 0.029
1.263HisGly: 1.263 ± 0.029
0.533HisHis: 0.533 ± 0.024
1.605HisIle: 1.605 ± 0.038
1.201HisLys: 1.201 ± 0.035
1.847HisLeu: 1.847 ± 0.042
0.326HisMet: 0.326 ± 0.017
1.025HisAsn: 1.025 ± 0.029
1.102HisPro: 1.102 ± 0.032
0.655HisGln: 0.655 ± 0.024
0.974HisArg: 0.974 ± 0.03
1.197HisSer: 1.197 ± 0.034
1.196HisThr: 1.196 ± 0.03
1.105HisVal: 1.105 ± 0.03
0.288HisTrp: 0.288 ± 0.016
1.05HisTyr: 1.05 ± 0.031
0.0HisXaa: 0.0 ± 0.0
Ile
5.0IleAla: 5.0 ± 0.076
1.038IleCys: 1.038 ± 0.03
4.155IleAsp: 4.155 ± 0.056
4.462IleGlu: 4.462 ± 0.064
2.755IlePhe: 2.755 ± 0.053
4.658IleGly: 4.658 ± 0.08
1.494IleHis: 1.494 ± 0.037
4.576IleIle: 4.576 ± 0.078
4.312IleLys: 4.312 ± 0.069
5.956IleLeu: 5.956 ± 0.086
1.605IleMet: 1.605 ± 0.041
3.443IleAsn: 3.443 ± 0.06
3.174IlePro: 3.174 ± 0.052
2.144IleGln: 2.144 ± 0.043
3.42IleArg: 3.42 ± 0.056
4.424IleSer: 4.424 ± 0.069
3.948IleThr: 3.948 ± 0.065
4.292IleVal: 4.292 ± 0.071
0.74IleTrp: 0.74 ± 0.028
2.893IleTyr: 2.893 ± 0.053
0.0IleXaa: 0.0 ± 0.0
Lys
4.995LysAla: 4.995 ± 0.079
0.608LysCys: 0.608 ± 0.028
4.094LysAsp: 4.094 ± 0.063
6.175LysGlu: 6.175 ± 0.09
2.301LysPhe: 2.301 ± 0.045
4.667LysGly: 4.667 ± 0.066
1.303LysHis: 1.303 ± 0.029
4.279LysIle: 4.279 ± 0.067
5.301LysLys: 5.301 ± 0.077
5.526LysLeu: 5.526 ± 0.068
2.119LysMet: 2.119 ± 0.046
3.707LysAsn: 3.707 ± 0.061
2.152LysPro: 2.152 ± 0.038
2.625LysGln: 2.625 ± 0.05
3.281LysArg: 3.281 ± 0.058
3.318LysSer: 3.318 ± 0.056
3.624LysThr: 3.624 ± 0.052
4.438LysVal: 4.438 ± 0.065
0.803LysTrp: 0.803 ± 0.024
3.017LysTyr: 3.017 ± 0.047
0.0LysXaa: 0.0 ± 0.0
Leu
6.279LeuAla: 6.279 ± 0.081
1.412LeuCys: 1.412 ± 0.033
4.513LeuAsp: 4.513 ± 0.062
5.253LeuGlu: 5.253 ± 0.084
4.509LeuPhe: 4.509 ± 0.085
5.528LeuGly: 5.528 ± 0.077
1.841LeuHis: 1.841 ± 0.04
5.485LeuIle: 5.485 ± 0.096
6.485LeuLys: 6.485 ± 0.08
8.734LeuLeu: 8.734 ± 0.122
2.462LeuMet: 2.462 ± 0.045
4.78LeuAsn: 4.78 ± 0.06
4.015LeuPro: 4.015 ± 0.055
3.26LeuGln: 3.26 ± 0.055
4.01LeuArg: 4.01 ± 0.056
6.512LeuSer: 6.512 ± 0.089
4.982LeuThr: 4.982 ± 0.062
5.068LeuVal: 5.068 ± 0.072
1.084LeuTrp: 1.084 ± 0.03
3.797LeuTyr: 3.797 ± 0.066
0.0LeuXaa: 0.0 ± 0.0
Met
2.135MetAla: 2.135 ± 0.041
0.281MetCys: 0.281 ± 0.018
1.613MetAsp: 1.613 ± 0.04
1.997MetGlu: 1.997 ± 0.044
1.013MetPhe: 1.013 ± 0.032
1.886MetGly: 1.886 ± 0.04
0.48MetHis: 0.48 ± 0.019
1.713MetIle: 1.713 ± 0.043
2.691MetLys: 2.691 ± 0.044
2.499MetLeu: 2.499 ± 0.047
0.876MetMet: 0.876 ± 0.028
1.712MetAsn: 1.712 ± 0.033
1.213MetPro: 1.213 ± 0.03
1.098MetGln: 1.098 ± 0.028
1.338MetArg: 1.338 ± 0.036
1.528MetSer: 1.528 ± 0.032
1.507MetThr: 1.507 ± 0.039
1.687MetVal: 1.687 ± 0.039
0.274MetTrp: 0.274 ± 0.014
0.947MetTyr: 0.947 ± 0.03
0.0MetXaa: 0.0 ± 0.0
Asn
3.473AsnAla: 3.473 ± 0.063
0.581AsnCys: 0.581 ± 0.024
2.58AsnAsp: 2.58 ± 0.047
3.297AsnGlu: 3.297 ± 0.053
2.226AsnPhe: 2.226 ± 0.044
4.05AsnGly: 4.05 ± 0.061
1.048AsnHis: 1.048 ± 0.028
3.863AsnIle: 3.863 ± 0.068
3.375AsnLys: 3.375 ± 0.054
4.376AsnLeu: 4.376 ± 0.064
1.431AsnMet: 1.431 ± 0.033
2.721AsnAsn: 2.721 ± 0.06
2.481AsnPro: 2.481 ± 0.043
1.638AsnGln: 1.638 ± 0.039
2.565AsnArg: 2.565 ± 0.047
2.794AsnSer: 2.794 ± 0.054
2.725AsnThr: 2.725 ± 0.047
3.161AsnVal: 3.161 ± 0.06
0.679AsnTrp: 0.679 ± 0.028
2.44AsnTyr: 2.44 ± 0.053
0.0AsnXaa: 0.0 ± 0.0
Pro
2.825ProAla: 2.825 ± 0.055
0.452ProCys: 0.452 ± 0.02
2.57ProAsp: 2.57 ± 0.051
3.308ProGlu: 3.308 ± 0.049
1.81ProPhe: 1.81 ± 0.037
2.466ProGly: 2.466 ± 0.052
0.778ProHis: 0.778 ± 0.023
2.096ProIle: 2.096 ± 0.045
1.986ProLys: 1.986 ± 0.043
3.172ProLeu: 3.172 ± 0.052
0.965ProMet: 0.965 ± 0.031
1.606ProAsn: 1.606 ± 0.041
0.804ProPro: 0.804 ± 0.029
1.471ProGln: 1.471 ± 0.038
1.357ProArg: 1.357 ± 0.036
2.106ProSer: 2.106 ± 0.047
1.842ProThr: 1.842 ± 0.041
3.082ProVal: 3.082 ± 0.056
0.484ProTrp: 0.484 ± 0.018
1.773ProTyr: 1.773 ± 0.038
0.0ProXaa: 0.0 ± 0.0
Gln
2.492GlnAla: 2.492 ± 0.052
0.337GlnCys: 0.337 ± 0.019
1.688GlnAsp: 1.688 ± 0.039
2.362GlnGlu: 2.362 ± 0.055
1.354GlnPhe: 1.354 ± 0.034
2.113GlnGly: 2.113 ± 0.046
0.681GlnHis: 0.681 ± 0.022
2.345GlnIle: 2.345 ± 0.046
2.509GlnLys: 2.509 ± 0.041
3.225GlnLeu: 3.225 ± 0.051
1.018GlnMet: 1.018 ± 0.03
1.679GlnAsn: 1.679 ± 0.034
1.2GlnPro: 1.2 ± 0.031
1.492GlnGln: 1.492 ± 0.038
1.669GlnArg: 1.669 ± 0.038
1.866GlnSer: 1.866 ± 0.036
2.006GlnThr: 2.006 ± 0.043
2.154GlnVal: 2.154 ± 0.039
0.523GlnTrp: 0.523 ± 0.021
1.497GlnTyr: 1.497 ± 0.038
0.0GlnXaa: 0.0 ± 0.0
Arg
2.757ArgAla: 2.757 ± 0.044
0.522ArgCys: 0.522 ± 0.025
2.158ArgAsp: 2.158 ± 0.043
3.045ArgGlu: 3.045 ± 0.056
2.358ArgPhe: 2.358 ± 0.038
2.442ArgGly: 2.442 ± 0.051
1.019ArgHis: 1.019 ± 0.032
3.672ArgIle: 3.672 ± 0.06
3.659ArgLys: 3.659 ± 0.054
4.407ArgLeu: 4.407 ± 0.059
1.631ArgMet: 1.631 ± 0.036
2.466ArgAsn: 2.466 ± 0.043
1.624ArgPro: 1.624 ± 0.038
1.896ArgGln: 1.896 ± 0.041
2.29ArgArg: 2.29 ± 0.052
2.395ArgSer: 2.395 ± 0.043
2.453ArgThr: 2.453 ± 0.049
2.684ArgVal: 2.684 ± 0.051
0.687ArgTrp: 0.687 ± 0.023
2.303ArgTyr: 2.303 ± 0.046
0.0ArgXaa: 0.0 ± 0.0
Ser
3.912SerAla: 3.912 ± 0.06
0.842SerCys: 0.842 ± 0.028
3.254SerAsp: 3.254 ± 0.053
3.422SerGlu: 3.422 ± 0.06
3.304SerPhe: 3.304 ± 0.048
4.351SerGly: 4.351 ± 0.073
1.161SerHis: 1.161 ± 0.032
4.221SerIle: 4.221 ± 0.066
3.368SerLys: 3.368 ± 0.049
5.868SerLeu: 5.868 ± 0.073
1.489SerMet: 1.489 ± 0.041
2.638SerAsn: 2.638 ± 0.049
2.181SerPro: 2.181 ± 0.042
1.86SerGln: 1.86 ± 0.043
2.658SerArg: 2.658 ± 0.052
3.683SerSer: 3.683 ± 0.062
2.998SerThr: 2.998 ± 0.053
4.256SerVal: 4.256 ± 0.068
0.803SerTrp: 0.803 ± 0.028
2.69SerTyr: 2.69 ± 0.054
0.0SerXaa: 0.0 ± 0.0
Thr
3.907ThrAla: 3.907 ± 0.063
0.595ThrCys: 0.595 ± 0.025
3.366ThrAsp: 3.366 ± 0.056
3.332ThrGlu: 3.332 ± 0.056
2.753ThrPhe: 2.753 ± 0.048
4.417ThrGly: 4.417 ± 0.069
1.125ThrHis: 1.125 ± 0.032
3.77ThrIle: 3.77 ± 0.064
2.765ThrLys: 2.765 ± 0.052
5.338ThrLeu: 5.338 ± 0.07
1.217ThrMet: 1.217 ± 0.034
2.499ThrAsn: 2.499 ± 0.054
2.709ThrPro: 2.709 ± 0.045
1.769ThrGln: 1.769 ± 0.037
2.287ThrArg: 2.287 ± 0.045
3.149ThrSer: 3.149 ± 0.054
3.047ThrThr: 3.047 ± 0.055
3.856ThrVal: 3.856 ± 0.059
0.701ThrTrp: 0.701 ± 0.025
2.367ThrTyr: 2.367 ± 0.049
0.0ThrXaa: 0.0 ± 0.0
Val
4.619ValAla: 4.619 ± 0.068
1.013ValCys: 1.013 ± 0.03
3.584ValAsp: 3.584 ± 0.058
4.099ValGlu: 4.099 ± 0.054
2.936ValPhe: 2.936 ± 0.05
3.95ValGly: 3.95 ± 0.061
1.176ValHis: 1.176 ± 0.031
4.321ValIle: 4.321 ± 0.066
4.34ValLys: 4.34 ± 0.052
5.756ValLeu: 5.756 ± 0.084
1.793ValMet: 1.793 ± 0.043
3.392ValAsn: 3.392 ± 0.051
2.622ValPro: 2.622 ± 0.05
1.861ValGln: 1.861 ± 0.039
3.015ValArg: 3.015 ± 0.054
4.341ValSer: 4.341 ± 0.063
3.758ValThr: 3.758 ± 0.06
4.374ValVal: 4.374 ± 0.078
0.79ValTrp: 0.79 ± 0.028
2.642ValTyr: 2.642 ± 0.048
0.0ValXaa: 0.0 ± 0.0
Trp
0.838TrpAla: 0.838 ± 0.03
0.207TrpCys: 0.207 ± 0.014
0.692TrpAsp: 0.692 ± 0.029
0.864TrpGlu: 0.864 ± 0.028
0.624TrpPhe: 0.624 ± 0.025
1.03TrpGly: 1.03 ± 0.034
0.294TrpHis: 0.294 ± 0.018
0.845TrpIle: 0.845 ± 0.029
0.966TrpLys: 0.966 ± 0.031
1.187TrpLeu: 1.187 ± 0.036
0.467TrpMet: 0.467 ± 0.021
0.885TrpAsn: 0.885 ± 0.032
0.289TrpPro: 0.289 ± 0.016
0.523TrpGln: 0.523 ± 0.022
0.573TrpArg: 0.573 ± 0.023
0.74TrpSer: 0.74 ± 0.026
0.697TrpThr: 0.697 ± 0.027
0.748TrpVal: 0.748 ± 0.023
0.215TrpTrp: 0.215 ± 0.016
0.556TrpTyr: 0.556 ± 0.023
0.0TrpXaa: 0.0 ± 0.0
Tyr
3.06TyrAla: 3.06 ± 0.053
0.617TyrCys: 0.617 ± 0.022
2.538TyrAsp: 2.538 ± 0.049
2.526TyrGlu: 2.526 ± 0.051
2.177TyrPhe: 2.177 ± 0.041
3.068TyrGly: 3.068 ± 0.06
1.025TyrHis: 1.025 ± 0.03
2.972TyrIle: 2.972 ± 0.053
2.906TyrLys: 2.906 ± 0.053
4.06TyrLeu: 4.06 ± 0.063
1.195TyrMet: 1.195 ± 0.034
2.514TyrAsn: 2.514 ± 0.055
1.882TyrPro: 1.882 ± 0.038
1.667TyrGln: 1.667 ± 0.036
2.288TyrArg: 2.288 ± 0.042
2.659TyrSer: 2.659 ± 0.046
2.65TyrThr: 2.65 ± 0.049
2.522TyrVal: 2.522 ± 0.05
0.637TyrTrp: 0.637 ± 0.024
2.229TyrTyr: 2.229 ± 0.05
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 3558 proteins (1234531 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski