Amino acid dipepetide frequency for Gramella fulva

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
4.649AlaAla: 4.649 ± 0.073
0.522AlaCys: 0.522 ± 0.025
3.437AlaAsp: 3.437 ± 0.061
4.797AlaGlu: 4.797 ± 0.068
3.186AlaPhe: 3.186 ± 0.055
4.746AlaGly: 4.746 ± 0.148
1.159AlaHis: 1.159 ± 0.033
5.018AlaIle: 5.018 ± 0.084
4.304AlaLys: 4.304 ± 0.087
5.853AlaLeu: 5.853 ± 0.085
1.607AlaMet: 1.607 ± 0.045
3.04AlaAsn: 3.04 ± 0.053
2.038AlaPro: 2.038 ± 0.044
2.286AlaGln: 2.286 ± 0.05
2.382AlaArg: 2.382 ± 0.055
4.13AlaSer: 4.13 ± 0.068
3.377AlaThr: 3.377 ± 0.179
4.262AlaVal: 4.262 ± 0.08
0.675AlaTrp: 0.675 ± 0.024
2.423AlaTyr: 2.423 ± 0.053
0.0AlaXaa: 0.0 ± 0.0
Cys
0.416CysAla: 0.416 ± 0.022
0.111CysCys: 0.111 ± 0.011
0.457CysAsp: 0.457 ± 0.046
0.484CysGlu: 0.484 ± 0.022
0.348CysPhe: 0.348 ± 0.016
0.569CysGly: 0.569 ± 0.023
0.158CysHis: 0.158 ± 0.012
0.499CysIle: 0.499 ± 0.019
0.418CysLys: 0.418 ± 0.02
0.601CysLeu: 0.601 ± 0.022
0.143CysMet: 0.143 ± 0.01
0.353CysAsn: 0.353 ± 0.019
0.314CysPro: 0.314 ± 0.019
0.221CysGln: 0.221 ± 0.013
0.258CysArg: 0.258 ± 0.015
0.557CysSer: 0.557 ± 0.031
0.366CysThr: 0.366 ± 0.02
0.374CysVal: 0.374 ± 0.018
0.071CysTrp: 0.071 ± 0.007
0.255CysTyr: 0.255 ± 0.015
0.0CysXaa: 0.0 ± 0.0
Asp
3.362AspAla: 3.362 ± 0.061
0.383AspCys: 0.383 ± 0.032
2.824AspAsp: 2.824 ± 0.088
4.11AspGlu: 4.11 ± 0.067
3.763AspPhe: 3.763 ± 0.062
3.629AspGly: 3.629 ± 0.076
1.189AspHis: 1.189 ± 0.034
4.114AspIle: 4.114 ± 0.061
3.882AspLys: 3.882 ± 0.068
5.773AspLeu: 5.773 ± 0.076
1.138AspMet: 1.138 ± 0.033
2.806AspAsn: 2.806 ± 0.101
2.321AspPro: 2.321 ± 0.052
1.823AspGln: 1.823 ± 0.037
2.23AspArg: 2.23 ± 0.044
3.309AspSer: 3.309 ± 0.054
2.508AspThr: 2.508 ± 0.043
3.173AspVal: 3.173 ± 0.054
0.775AspTrp: 0.775 ± 0.024
2.902AspTyr: 2.902 ± 0.074
0.0AspXaa: 0.0 ± 0.0
Glu
4.687GluAla: 4.687 ± 0.064
0.366GluCys: 0.366 ± 0.017
4.048GluAsp: 4.048 ± 0.059
6.251GluGlu: 6.251 ± 0.112
3.215GluPhe: 3.215 ± 0.064
4.288GluGly: 4.288 ± 0.058
1.21GluHis: 1.21 ± 0.034
6.333GluIle: 6.333 ± 0.092
7.521GluLys: 7.521 ± 0.11
6.549GluLeu: 6.549 ± 0.084
1.845GluMet: 1.845 ± 0.042
5.393GluAsn: 5.393 ± 0.079
1.904GluPro: 1.904 ± 0.038
2.221GluGln: 2.221 ± 0.045
2.77GluArg: 2.77 ± 0.053
3.347GluSer: 3.347 ± 0.049
3.494GluThr: 3.494 ± 0.059
4.675GluVal: 4.675 ± 0.067
0.74GluTrp: 0.74 ± 0.024
2.681GluTyr: 2.681 ± 0.051
0.0GluXaa: 0.0 ± 0.0
Phe
2.951PheAla: 2.951 ± 0.048
0.426PheCys: 0.426 ± 0.02
3.089PheAsp: 3.089 ± 0.06
3.568PheGlu: 3.568 ± 0.06
2.88PhePhe: 2.88 ± 0.063
3.619PheGly: 3.619 ± 0.058
0.939PheHis: 0.939 ± 0.028
3.777PheIle: 3.777 ± 0.063
3.481PheLys: 3.481 ± 0.065
5.149PheLeu: 5.149 ± 0.082
1.126PheMet: 1.126 ± 0.031
2.839PheAsn: 2.839 ± 0.059
1.961PhePro: 1.961 ± 0.038
1.826PheGln: 1.826 ± 0.042
2.135PheArg: 2.135 ± 0.045
4.201PheSer: 4.201 ± 0.064
2.865PheThr: 2.865 ± 0.081
2.655PheVal: 2.655 ± 0.046
0.673PheTrp: 0.673 ± 0.025
2.184PheTyr: 2.184 ± 0.042
0.0PheXaa: 0.0 ± 0.0
Gly
4.162GlyAla: 4.162 ± 0.065
0.537GlyCys: 0.537 ± 0.021
3.591GlyAsp: 3.591 ± 0.071
4.301GlyGlu: 4.301 ± 0.057
3.624GlyPhe: 3.624 ± 0.059
4.576GlyGly: 4.576 ± 0.088
1.177GlyHis: 1.177 ± 0.029
5.628GlyIle: 5.628 ± 0.082
5.397GlyLys: 5.397 ± 0.088
5.825GlyLeu: 5.825 ± 0.081
1.786GlyMet: 1.786 ± 0.046
3.811GlyAsn: 3.811 ± 0.071
1.563GlyPro: 1.563 ± 0.041
1.818GlyGln: 1.818 ± 0.042
2.457GlyArg: 2.457 ± 0.044
4.172GlySer: 4.172 ± 0.134
3.836GlyThr: 3.836 ± 0.167
4.089GlyVal: 4.089 ± 0.062
0.881GlyTrp: 0.881 ± 0.025
2.818GlyTyr: 2.818 ± 0.065
0.0GlyXaa: 0.0 ± 0.0
His
0.908HisAla: 0.908 ± 0.028
0.163HisCys: 0.163 ± 0.011
0.878HisAsp: 0.878 ± 0.026
1.149HisGlu: 1.149 ± 0.035
1.227HisPhe: 1.227 ± 0.034
1.197HisGly: 1.197 ± 0.036
0.505HisHis: 0.505 ± 0.022
1.305HisIle: 1.305 ± 0.031
1.207HisLys: 1.207 ± 0.039
1.844HisLeu: 1.844 ± 0.047
0.324HisMet: 0.324 ± 0.016
0.872HisAsn: 0.872 ± 0.031
1.031HisPro: 1.031 ± 0.031
0.762HisGln: 0.762 ± 0.026
0.788HisArg: 0.788 ± 0.025
1.189HisSer: 1.189 ± 0.031
0.91HisThr: 0.91 ± 0.03
0.868HisVal: 0.868 ± 0.027
0.246HisTrp: 0.246 ± 0.013
0.842HisTyr: 0.842 ± 0.027
0.0HisXaa: 0.0 ± 0.0
Ile
5.226IleAla: 5.226 ± 0.101
0.575IleCys: 0.575 ± 0.025
4.547IleAsp: 4.547 ± 0.066
5.149IleGlu: 5.149 ± 0.072
3.946IlePhe: 3.946 ± 0.075
4.854IleGly: 4.854 ± 0.077
1.384IleHis: 1.384 ± 0.036
5.547IleIle: 5.547 ± 0.08
5.4IleLys: 5.4 ± 0.077
7.269IleLeu: 7.269 ± 0.103
1.348IleMet: 1.348 ± 0.036
4.124IleAsn: 4.124 ± 0.064
3.413IlePro: 3.413 ± 0.056
2.56IleGln: 2.56 ± 0.053
2.959IleArg: 2.959 ± 0.046
5.89IleSer: 5.89 ± 0.112
4.092IleThr: 4.092 ± 0.135
4.056IleVal: 4.056 ± 0.055
0.773IleTrp: 0.773 ± 0.026
2.82IleTyr: 2.82 ± 0.052
0.0IleXaa: 0.0 ± 0.0
Lys
5.032LysAla: 5.032 ± 0.082
0.328LysCys: 0.328 ± 0.017
4.677LysAsp: 4.677 ± 0.082
6.899LysGlu: 6.899 ± 0.111
3.129LysPhe: 3.129 ± 0.052
4.51LysGly: 4.51 ± 0.072
1.245LysHis: 1.245 ± 0.028
6.337LysIle: 6.337 ± 0.091
7.447LysLys: 7.447 ± 0.114
6.831LysLeu: 6.831 ± 0.106
2.113LysMet: 2.113 ± 0.046
5.268LysAsn: 5.268 ± 0.08
2.564LysPro: 2.564 ± 0.052
2.306LysGln: 2.306 ± 0.048
3.051LysArg: 3.051 ± 0.06
4.202LysSer: 4.202 ± 0.07
4.106LysThr: 4.106 ± 0.069
4.424LysVal: 4.424 ± 0.07
0.852LysTrp: 0.852 ± 0.029
2.973LysTyr: 2.973 ± 0.053
0.0LysXaa: 0.0 ± 0.0
Leu
5.89LeuAla: 5.89 ± 0.077
0.63LeuCys: 0.63 ± 0.022
5.042LeuAsp: 5.042 ± 0.064
6.706LeuGlu: 6.706 ± 0.089
4.753LeuPhe: 4.753 ± 0.077
5.902LeuGly: 5.902 ± 0.083
1.696LeuHis: 1.696 ± 0.043
6.838LeuIle: 6.838 ± 0.092
8.36LeuLys: 8.36 ± 0.129
8.78LeuLeu: 8.78 ± 0.135
2.133LeuMet: 2.133 ± 0.045
5.375LeuAsn: 5.375 ± 0.075
3.66LeuPro: 3.66 ± 0.055
3.543LeuGln: 3.543 ± 0.058
3.63LeuArg: 3.63 ± 0.06
6.557LeuSer: 6.557 ± 0.096
4.517LeuThr: 4.517 ± 0.089
5.204LeuVal: 5.204 ± 0.066
0.938LeuTrp: 0.938 ± 0.03
3.154LeuTyr: 3.154 ± 0.055
0.0LeuXaa: 0.0 ± 0.0
Met
1.812MetAla: 1.812 ± 0.042
0.121MetCys: 0.121 ± 0.008
1.265MetAsp: 1.265 ± 0.032
1.705MetGlu: 1.705 ± 0.039
0.839MetPhe: 0.839 ± 0.025
1.543MetGly: 1.543 ± 0.041
0.415MetHis: 0.415 ± 0.02
1.597MetIle: 1.597 ± 0.039
2.314MetLys: 2.314 ± 0.045
2.052MetLeu: 2.052 ± 0.049
0.614MetMet: 0.614 ± 0.027
1.275MetAsn: 1.275 ± 0.031
0.898MetPro: 0.898 ± 0.027
0.817MetGln: 0.817 ± 0.026
0.919MetArg: 0.919 ± 0.032
1.306MetSer: 1.306 ± 0.033
1.035MetThr: 1.035 ± 0.03
1.365MetVal: 1.365 ± 0.036
0.195MetTrp: 0.195 ± 0.011
0.698MetTyr: 0.698 ± 0.025
0.0MetXaa: 0.0 ± 0.0
Asn
3.45AsnAla: 3.45 ± 0.068
0.453AsnCys: 0.453 ± 0.031
3.092AsnAsp: 3.092 ± 0.079
3.679AsnGlu: 3.679 ± 0.053
3.382AsnPhe: 3.382 ± 0.061
3.822AsnGly: 3.822 ± 0.082
0.995AsnHis: 0.995 ± 0.028
4.391AsnIle: 4.391 ± 0.063
3.707AsnLys: 3.707 ± 0.065
5.342AsnLeu: 5.342 ± 0.073
1.253AsnMet: 1.253 ± 0.029
3.096AsnAsn: 3.096 ± 0.068
2.695AsnPro: 2.695 ± 0.049
1.909AsnGln: 1.909 ± 0.039
2.391AsnArg: 2.391 ± 0.048
3.862AsnSer: 3.862 ± 0.071
3.0AsnThr: 3.0 ± 0.074
2.939AsnVal: 2.939 ± 0.064
0.774AsnTrp: 0.774 ± 0.027
2.769AsnTyr: 2.769 ± 0.057
0.0AsnXaa: 0.0 ± 0.0
Pro
2.364ProAla: 2.364 ± 0.071
0.198ProCys: 0.198 ± 0.014
2.51ProAsp: 2.51 ± 0.05
3.617ProGlu: 3.617 ± 0.068
1.9ProPhe: 1.9 ± 0.041
2.628ProGly: 2.628 ± 0.06
0.684ProHis: 0.684 ± 0.024
2.278ProIle: 2.278 ± 0.043
2.461ProLys: 2.461 ± 0.051
3.15ProLeu: 3.15 ± 0.052
0.768ProMet: 0.768 ± 0.027
1.814ProAsn: 1.814 ± 0.043
1.026ProPro: 1.026 ± 0.036
1.313ProGln: 1.313 ± 0.038
1.073ProArg: 1.073 ± 0.029
2.214ProSer: 2.214 ± 0.05
1.726ProThr: 1.726 ± 0.045
2.917ProVal: 2.917 ± 0.056
0.411ProTrp: 0.411 ± 0.018
1.426ProTyr: 1.426 ± 0.033
0.0ProXaa: 0.0 ± 0.0
Gln
2.129GlnAla: 2.129 ± 0.047
0.156GlnCys: 0.156 ± 0.013
1.774GlnAsp: 1.774 ± 0.041
2.654GlnGlu: 2.654 ± 0.046
1.582GlnPhe: 1.582 ± 0.039
1.814GlnGly: 1.814 ± 0.042
0.593GlnHis: 0.593 ± 0.025
2.502GlnIle: 2.502 ± 0.048
3.154GlnLys: 3.154 ± 0.058
3.346GlnLeu: 3.346 ± 0.057
0.849GlnMet: 0.849 ± 0.031
2.231GlnAsn: 2.231 ± 0.038
1.184GlnPro: 1.184 ± 0.032
1.469GlnGln: 1.469 ± 0.037
1.402GlnArg: 1.402 ± 0.036
1.736GlnSer: 1.736 ± 0.038
1.708GlnThr: 1.708 ± 0.047
2.006GlnVal: 2.006 ± 0.04
0.344GlnTrp: 0.344 ± 0.017
1.192GlnTyr: 1.192 ± 0.035
0.0GlnXaa: 0.0 ± 0.0
Arg
2.277ArgAla: 2.277 ± 0.038
0.201ArgCys: 0.201 ± 0.012
2.092ArgAsp: 2.092 ± 0.044
3.056ArgGlu: 3.056 ± 0.061
2.103ArgPhe: 2.103 ± 0.047
2.151ArgGly: 2.151 ± 0.044
0.759ArgHis: 0.759 ± 0.025
3.215ArgIle: 3.215 ± 0.056
3.573ArgLys: 3.573 ± 0.061
3.626ArgLeu: 3.626 ± 0.061
0.973ArgMet: 0.973 ± 0.027
2.551ArgAsn: 2.551 ± 0.051
1.274ArgPro: 1.274 ± 0.032
1.368ArgGln: 1.368 ± 0.031
1.649ArgArg: 1.649 ± 0.037
2.246ArgSer: 2.246 ± 0.043
1.823ArgThr: 1.823 ± 0.04
2.145ArgVal: 2.145 ± 0.042
0.467ArgTrp: 0.467 ± 0.019
1.649ArgTyr: 1.649 ± 0.042
0.0ArgXaa: 0.0 ± 0.0
Ser
3.916SerAla: 3.916 ± 0.07
0.581SerCys: 0.581 ± 0.025
3.528SerAsp: 3.528 ± 0.07
4.806SerGlu: 4.806 ± 0.067
3.705SerPhe: 3.705 ± 0.061
4.836SerGly: 4.836 ± 0.094
1.172SerHis: 1.172 ± 0.032
4.82SerIle: 4.82 ± 0.111
4.422SerLys: 4.422 ± 0.063
6.332SerLeu: 6.332 ± 0.079
1.319SerMet: 1.319 ± 0.032
3.245SerAsn: 3.245 ± 0.062
2.235SerPro: 2.235 ± 0.041
2.068SerGln: 2.068 ± 0.043
2.673SerArg: 2.673 ± 0.054
4.233SerSer: 4.233 ± 0.078
3.108SerThr: 3.108 ± 0.096
3.886SerVal: 3.886 ± 0.108
0.787SerTrp: 0.787 ± 0.026
2.606SerTyr: 2.606 ± 0.053
0.0SerXaa: 0.0 ± 0.0
Thr
3.728ThrAla: 3.728 ± 0.168
0.344ThrCys: 0.344 ± 0.022
2.91ThrAsp: 2.91 ± 0.077
3.319ThrGlu: 3.319 ± 0.055
2.593ThrPhe: 2.593 ± 0.102
4.355ThrGly: 4.355 ± 0.106
0.894ThrHis: 0.894 ± 0.023
3.81ThrIle: 3.81 ± 0.175
3.029ThrLys: 3.029 ± 0.055
4.424ThrLeu: 4.424 ± 0.105
0.92ThrMet: 0.92 ± 0.025
2.6ThrAsn: 2.6 ± 0.059
2.248ThrPro: 2.248 ± 0.058
1.605ThrGln: 1.605 ± 0.054
1.91ThrArg: 1.91 ± 0.041
3.602ThrSer: 3.602 ± 0.078
2.796ThrThr: 2.796 ± 0.102
3.434ThrVal: 3.434 ± 0.164
0.587ThrTrp: 0.587 ± 0.025
2.125ThrTyr: 2.125 ± 0.052
0.0ThrXaa: 0.0 ± 0.0
Val
3.892ValAla: 3.892 ± 0.064
0.461ValCys: 0.461 ± 0.02
3.286ValAsp: 3.286 ± 0.058
3.988ValGlu: 3.988 ± 0.067
3.127ValPhe: 3.127 ± 0.052
3.558ValGly: 3.558 ± 0.057
0.978ValHis: 0.978 ± 0.027
4.663ValIle: 4.663 ± 0.071
4.449ValLys: 4.449 ± 0.079
5.49ValLeu: 5.49 ± 0.072
1.416ValMet: 1.416 ± 0.038
3.27ValAsn: 3.27 ± 0.09
2.231ValPro: 2.231 ± 0.041
1.893ValGln: 1.893 ± 0.043
2.161ValArg: 2.161 ± 0.052
4.106ValSer: 4.106 ± 0.132
3.256ValThr: 3.256 ± 0.162
3.85ValVal: 3.85 ± 0.061
0.658ValTrp: 0.658 ± 0.026
2.249ValTyr: 2.249 ± 0.041
0.0ValXaa: 0.0 ± 0.0
Trp
0.656TrpAla: 0.656 ± 0.025
0.094TrpCys: 0.094 ± 0.009
0.665TrpAsp: 0.665 ± 0.022
0.758TrpGlu: 0.758 ± 0.028
0.6TrpPhe: 0.6 ± 0.024
0.718TrpGly: 0.718 ± 0.025
0.252TrpHis: 0.252 ± 0.015
0.838TrpIle: 0.838 ± 0.03
0.972TrpLys: 0.972 ± 0.032
1.057TrpLeu: 1.057 ± 0.029
0.342TrpMet: 0.342 ± 0.017
0.762TrpAsn: 0.762 ± 0.029
0.349TrpPro: 0.349 ± 0.016
0.456TrpGln: 0.456 ± 0.019
0.471TrpArg: 0.471 ± 0.02
0.657TrpSer: 0.657 ± 0.021
0.561TrpThr: 0.561 ± 0.025
0.625TrpVal: 0.625 ± 0.025
0.185TrpTrp: 0.185 ± 0.012
0.507TrpTyr: 0.507 ± 0.027
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.385TyrAla: 2.385 ± 0.043
0.324TyrCys: 0.324 ± 0.017
2.301TyrAsp: 2.301 ± 0.043
2.541TyrGlu: 2.541 ± 0.055
2.443TyrPhe: 2.443 ± 0.048
2.735TyrGly: 2.735 ± 0.065
0.812TyrHis: 0.812 ± 0.028
2.423TyrIle: 2.423 ± 0.039
2.796TyrLys: 2.796 ± 0.059
4.016TyrLeu: 4.016 ± 0.057
0.771TyrMet: 0.771 ± 0.025
2.277TyrAsn: 2.277 ± 0.048
1.568TyrPro: 1.568 ± 0.038
1.561TyrGln: 1.561 ± 0.038
1.888TyrArg: 1.888 ± 0.048
2.763TyrSer: 2.763 ± 0.06
2.148TyrThr: 2.148 ± 0.081
2.032TyrVal: 2.032 ± 0.043
0.491TyrTrp: 0.491 ± 0.02
1.859TyrTyr: 1.859 ± 0.054
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 3785 proteins (1310285 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski