Amino acid dipepetide frequency for Blastococcus saxobsidens

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	23.668AlaAla: 23.668 ± 0.234	0.926AlaCys: 0.926 ± 0.03	9.15AlaAsp: 9.15 ± 0.1	9.023AlaGlu: 9.023 ± 0.095	3.452AlaPhe: 3.452 ± 0.051	14.884AlaGly: 14.884 ± 0.121	2.512AlaHis: 2.512 ± 0.048	3.76AlaIle: 3.76 ± 0.061	1.896AlaLys: 1.896 ± 0.05	15.156AlaLeu: 15.156 ± 0.138	2.61AlaMet: 2.61 ± 0.045	1.713AlaAsn: 1.713 ± 0.037	7.448AlaPro: 7.448 ± 0.104	3.835AlaGln: 3.835 ± 0.063	10.716AlaArg: 10.716 ± 0.099	5.743AlaSer: 5.743 ± 0.073	7.601AlaThr: 7.601 ± 0.092	14.086AlaVal: 14.086 ± 0.123	1.866AlaTrp: 1.866 ± 0.041	2.217AlaTyr: 2.217 ± 0.038	0.0AlaXaa: 0.0 ± 0.0
Cys	0.85CysAla: 0.85 ± 0.029	0.103CysCys: 0.103 ± 0.009	0.45CysAsp: 0.45 ± 0.018	0.312CysGlu: 0.312 ± 0.015	0.189CysPhe: 0.189 ± 0.013	0.908CysGly: 0.908 ± 0.033	0.161CysHis: 0.161 ± 0.01	0.187CysIle: 0.187 ± 0.012	0.067CysLys: 0.067 ± 0.008	0.64CysLeu: 0.64 ± 0.026	0.089CysMet: 0.089 ± 0.008	0.105CysAsn: 0.105 ± 0.01	0.473CysPro: 0.473 ± 0.022	0.122CysGln: 0.122 ± 0.01	0.582CysArg: 0.582 ± 0.02	0.36CysSer: 0.36 ± 0.017	0.433CysThr: 0.433 ± 0.018	0.522CysVal: 0.522 ± 0.017	0.102CysTrp: 0.102 ± 0.009	0.112CysTyr: 0.112 ± 0.009	0.0CysXaa: 0.0 ± 0.0
Asp	8.171AspAla: 8.171 ± 0.084	0.343AspCys: 0.343 ± 0.018	4.201AspAsp: 4.201 ± 0.063	4.189AspGlu: 4.189 ± 0.054	1.402AspPhe: 1.402 ± 0.036	6.634AspGly: 6.634 ± 0.087	1.227AspHis: 1.227 ± 0.033	1.573AspIle: 1.573 ± 0.042	0.731AspLys: 0.731 ± 0.025	6.889AspLeu: 6.889 ± 0.074	0.782AspMet: 0.782 ± 0.025	0.707AspAsn: 0.707 ± 0.025	4.71AspPro: 4.71 ± 0.057	1.599AspGln: 1.599 ± 0.04	5.396AspArg: 5.396 ± 0.061	2.234AspSer: 2.234 ± 0.042	2.691AspThr: 2.691 ± 0.053	6.403AspVal: 6.403 ± 0.071	0.905AspTrp: 0.905 ± 0.026	1.011AspTyr: 1.011 ± 0.027	0.0AspXaa: 0.0 ± 0.0
Glu	7.232GluAla: 7.232 ± 0.096	0.313GluCys: 0.313 ± 0.017	3.058GluAsp: 3.058 ± 0.054	3.562GluGlu: 3.562 ± 0.062	1.44GluPhe: 1.44 ± 0.03	4.316GluGly: 4.316 ± 0.06	1.563GluHis: 1.563 ± 0.037	2.029GluIle: 2.029 ± 0.039	1.009GluLys: 1.009 ± 0.034	7.133GluLeu: 7.133 ± 0.085	0.884GluMet: 0.884 ± 0.027	0.916GluAsn: 0.916 ± 0.033	3.46GluPro: 3.46 ± 0.071	2.515GluGln: 2.515 ± 0.05	5.262GluArg: 5.262 ± 0.069	2.338GluSer: 2.338 ± 0.042	2.676GluThr: 2.676 ± 0.053	5.337GluVal: 5.337 ± 0.067	0.763GluTrp: 0.763 ± 0.024	0.938GluTyr: 0.938 ± 0.026	0.0GluXaa: 0.0 ± 0.0
Phe	3.649PheAla: 3.649 ± 0.056	0.236PheCys: 0.236 ± 0.016	1.925PheAsp: 1.925 ± 0.035	1.336PheGlu: 1.336 ± 0.037	0.84PhePhe: 0.84 ± 0.025	2.97PheGly: 2.97 ± 0.051	0.455PheHis: 0.455 ± 0.017	0.649PheIle: 0.649 ± 0.025	0.331PheLys: 0.331 ± 0.017	2.63PheLeu: 2.63 ± 0.049	0.338PheMet: 0.338 ± 0.018	0.426PheAsn: 0.426 ± 0.02	1.392PhePro: 1.392 ± 0.036	0.618PheGln: 0.618 ± 0.024	1.685PheArg: 1.685 ± 0.042	1.385PheSer: 1.385 ± 0.04	1.76PheThr: 1.76 ± 0.039	2.538PheVal: 2.538 ± 0.045	0.413PheTrp: 0.413 ± 0.021	0.552PheTyr: 0.552 ± 0.021	0.0PheXaa: 0.0 ± 0.0
Gly	11.937GlyAla: 11.937 ± 0.129	0.841GlyCys: 0.841 ± 0.029	5.363GlyAsp: 5.363 ± 0.067	5.317GlyGlu: 5.317 ± 0.081	2.864GlyPhe: 2.864 ± 0.047	9.108GlyGly: 9.108 ± 0.106	1.965GlyHis: 1.965 ± 0.045	3.426GlyIle: 3.426 ± 0.052	1.695GlyLys: 1.695 ± 0.045	10.28GlyLeu: 10.28 ± 0.098	2.163GlyMet: 2.163 ± 0.046	1.562GlyAsn: 1.562 ± 0.04	5.308GlyPro: 5.308 ± 0.067	2.754GlyGln: 2.754 ± 0.053	8.21GlyArg: 8.21 ± 0.078	5.593GlySer: 5.593 ± 0.064	6.17GlyThr: 6.17 ± 0.069	8.541GlyVal: 8.541 ± 0.084	1.814GlyTrp: 1.814 ± 0.047	2.193GlyTyr: 2.193 ± 0.049	0.0GlyXaa: 0.0 ± 0.0
His	2.419HisAla: 2.419 ± 0.044	0.164HisCys: 0.164 ± 0.012	1.201HisAsp: 1.201 ± 0.035	1.114HisGlu: 1.114 ± 0.032	0.526HisPhe: 0.526 ± 0.024	2.196HisGly: 2.196 ± 0.045	0.546HisHis: 0.546 ± 0.023	0.439HisIle: 0.439 ± 0.019	0.217HisLys: 0.217 ± 0.013	2.141HisLeu: 2.141 ± 0.04	0.288HisMet: 0.288 ± 0.014	0.248HisAsn: 0.248 ± 0.014	1.669HisPro: 1.669 ± 0.039	0.51HisGln: 0.51 ± 0.02	1.851HisArg: 1.851 ± 0.039	0.827HisSer: 0.827 ± 0.027	0.935HisThr: 0.935 ± 0.025	1.845HisVal: 1.845 ± 0.037	0.294HisTrp: 0.294 ± 0.014	0.36HisTyr: 0.36 ± 0.017	0.0HisXaa: 0.0 ± 0.0
Ile	4.654IleAla: 4.654 ± 0.07	0.238IleCys: 0.238 ± 0.013	2.269IleAsp: 2.269 ± 0.042	1.867IleGlu: 1.867 ± 0.043	0.624IlePhe: 0.624 ± 0.023	3.5IleGly: 3.5 ± 0.055	0.396IleHis: 0.396 ± 0.019	0.781IleIle: 0.781 ± 0.028	0.456IleLys: 0.456 ± 0.02	2.062IleLeu: 2.062 ± 0.042	0.381IleMet: 0.381 ± 0.019	0.591IleAsn: 0.591 ± 0.021	1.543IlePro: 1.543 ± 0.032	0.653IleGln: 0.653 ± 0.025	2.011IleArg: 2.011 ± 0.039	1.663IleSer: 1.663 ± 0.034	1.912IleThr: 1.912 ± 0.037	2.67IleVal: 2.67 ± 0.05	0.346IleTrp: 0.346 ± 0.017	0.48IleTyr: 0.48 ± 0.021	0.0IleXaa: 0.0 ± 0.0
Lys	1.998LysAla: 1.998 ± 0.057	0.056LysCys: 0.056 ± 0.007	0.847LysAsp: 0.847 ± 0.029	0.732LysGlu: 0.732 ± 0.024	0.303LysPhe: 0.303 ± 0.015	1.11LysGly: 1.11 ± 0.031	0.288LysHis: 0.288 ± 0.014	0.508LysIle: 0.508 ± 0.023	0.506LysLys: 0.506 ± 0.027	1.388LysLeu: 1.388 ± 0.038	0.265LysMet: 0.265 ± 0.015	0.321LysAsn: 0.321 ± 0.018	0.863LysPro: 0.863 ± 0.027	0.486LysGln: 0.486 ± 0.02	1.102LysArg: 1.102 ± 0.031	0.745LysSer: 0.745 ± 0.023	0.869LysThr: 0.869 ± 0.026	1.365LysVal: 1.365 ± 0.037	0.195LysTrp: 0.195 ± 0.011	0.3LysTyr: 0.3 ± 0.015	0.0LysXaa: 0.0 ± 0.0
Leu	16.89LeuAla: 16.89 ± 0.139	0.674LeuCys: 0.674 ± 0.021	6.957LeuAsp: 6.957 ± 0.086	5.144LeuGlu: 5.144 ± 0.071	2.604LeuPhe: 2.604 ± 0.05	10.187LeuGly: 10.187 ± 0.091	2.03LeuHis: 2.03 ± 0.038	2.758LeuIle: 2.758 ± 0.049	1.264LeuLys: 1.264 ± 0.036	12.328LeuLeu: 12.328 ± 0.127	1.484LeuMet: 1.484 ± 0.04	1.324LeuAsn: 1.324 ± 0.033	6.882LeuPro: 6.882 ± 0.071	2.544LeuGln: 2.544 ± 0.045	8.589LeuArg: 8.589 ± 0.091	5.327LeuSer: 5.327 ± 0.063	6.68LeuThr: 6.68 ± 0.073	10.897LeuVal: 10.897 ± 0.114	1.18LeuTrp: 1.18 ± 0.033	1.414LeuTyr: 1.414 ± 0.04	0.0LeuXaa: 0.0 ± 0.0
Met	2.337MetAla: 2.337 ± 0.045	0.111MetCys: 0.111 ± 0.01	0.855MetAsp: 0.855 ± 0.027	0.668MetGlu: 0.668 ± 0.023	0.372MetPhe: 0.372 ± 0.017	1.341MetGly: 1.341 ± 0.039	0.349MetHis: 0.349 ± 0.016	0.551MetIle: 0.551 ± 0.023	0.304MetLys: 0.304 ± 0.016	1.591MetLeu: 1.591 ± 0.033	0.233MetMet: 0.233 ± 0.015	0.331MetAsn: 0.331 ± 0.016	1.102MetPro: 1.102 ± 0.032	0.473MetGln: 0.473 ± 0.018	1.375MetArg: 1.375 ± 0.029	1.357MetSer: 1.357 ± 0.032	1.685MetThr: 1.685 ± 0.035	1.376MetVal: 1.376 ± 0.028	0.177MetTrp: 0.177 ± 0.011	0.254MetTyr: 0.254 ± 0.014	0.0MetXaa: 0.0 ± 0.0
Asn	1.901AsnAla: 1.901 ± 0.037	0.129AsnCys: 0.129 ± 0.01	0.781AsnAsp: 0.781 ± 0.025	0.676AsnGlu: 0.676 ± 0.025	0.414AsnPhe: 0.414 ± 0.015	1.517AsnGly: 1.517 ± 0.043	0.3AsnHis: 0.3 ± 0.014	0.485AsnIle: 0.485 ± 0.019	0.231AsnLys: 0.231 ± 0.014	1.526AsnLeu: 1.526 ± 0.039	0.273AsnMet: 0.273 ± 0.015	0.287AsnAsn: 0.287 ± 0.016	1.128AsnPro: 1.128 ± 0.032	0.392AsnGln: 0.392 ± 0.017	1.13AsnArg: 1.13 ± 0.033	0.688AsnSer: 0.688 ± 0.023	0.844AsnThr: 0.844 ± 0.027	1.278AsnVal: 1.278 ± 0.03	0.217AsnTrp: 0.217 ± 0.015	0.309AsnTyr: 0.309 ± 0.015	0.0AsnXaa: 0.0 ± 0.0
Pro	9.533ProAla: 9.533 ± 0.101	0.283ProCys: 0.283 ± 0.015	4.552ProAsp: 4.552 ± 0.066	4.416ProGlu: 4.416 ± 0.064	1.594ProPhe: 1.594 ± 0.036	6.837ProGly: 6.837 ± 0.094	1.16ProHis: 1.16 ± 0.033	1.432ProIle: 1.432 ± 0.037	0.778ProLys: 0.778 ± 0.029	5.473ProLeu: 5.473 ± 0.069	0.999ProMet: 0.999 ± 0.029	0.739ProAsn: 0.739 ± 0.021	3.82ProPro: 3.82 ± 0.082	1.502ProGln: 1.502 ± 0.042	4.041ProArg: 4.041 ± 0.06	3.07ProSer: 3.07 ± 0.049	3.452ProThr: 3.452 ± 0.053	6.13ProVal: 6.13 ± 0.076	0.927ProTrp: 0.927 ± 0.026	1.026ProTyr: 1.026 ± 0.033	0.0ProXaa: 0.0 ± 0.0
Gln	3.723GlnAla: 3.723 ± 0.061	0.129GlnCys: 0.129 ± 0.01	1.233GlnAsp: 1.233 ± 0.034	1.498GlnGlu: 1.498 ± 0.036	0.74GlnPhe: 0.74 ± 0.024	2.039GlnGly: 2.039 ± 0.038	0.592GlnHis: 0.592 ± 0.021	0.996GlnIle: 0.996 ± 0.031	0.45GlnLys: 0.45 ± 0.022	3.293GlnLeu: 3.293 ± 0.05	0.502GlnMet: 0.502 ± 0.02	0.442GlnAsn: 0.442 ± 0.018	1.701GlnPro: 1.701 ± 0.041	1.229GlnGln: 1.229 ± 0.037	2.528GlnArg: 2.528 ± 0.047	1.089GlnSer: 1.089 ± 0.029	1.325GlnThr: 1.325 ± 0.029	2.856GlnVal: 2.856 ± 0.043	0.407GlnTrp: 0.407 ± 0.022	0.511GlnTyr: 0.511 ± 0.021	0.0GlnXaa: 0.0 ± 0.0
Arg	10.269ArgAla: 10.269 ± 0.092	0.538ArgCys: 0.538 ± 0.022	4.446ArgAsp: 4.446 ± 0.06	4.475ArgGlu: 4.475 ± 0.065	2.216ArgPhe: 2.216 ± 0.044	6.076ArgGly: 6.076 ± 0.07	1.704ArgHis: 1.704 ± 0.037	2.756ArgIle: 2.756 ± 0.049	1.126ArgLys: 1.126 ± 0.032	8.874ArgLeu: 8.874 ± 0.102	1.762ArgMet: 1.762 ± 0.035	1.206ArgAsn: 1.206 ± 0.032	5.376ArgPro: 5.376 ± 0.077	2.322ArgGln: 2.322 ± 0.041	8.336ArgArg: 8.336 ± 0.097	4.506ArgSer: 4.506 ± 0.06	5.167ArgThr: 5.167 ± 0.068	6.556ArgVal: 6.556 ± 0.069	1.542ArgTrp: 1.542 ± 0.039	1.662ArgTyr: 1.662 ± 0.037	0.0ArgXaa: 0.0 ± 0.0
Ser	6.82SerAla: 6.82 ± 0.079	0.34SerCys: 0.34 ± 0.018	2.659SerAsp: 2.659 ± 0.048	2.181SerGlu: 2.181 ± 0.047	1.49SerPhe: 1.49 ± 0.036	5.609SerGly: 5.609 ± 0.074	0.815SerHis: 0.815 ± 0.023	1.571SerIle: 1.571 ± 0.038	0.676SerLys: 0.676 ± 0.025	4.836SerLeu: 4.836 ± 0.063	1.066SerMet: 1.066 ± 0.029	0.708SerAsn: 0.708 ± 0.027	3.213SerPro: 3.213 ± 0.053	1.128SerGln: 1.128 ± 0.029	3.766SerArg: 3.766 ± 0.066	2.905SerSer: 2.905 ± 0.047	3.162SerThr: 3.162 ± 0.047	4.283SerVal: 4.283 ± 0.05	0.875SerTrp: 0.875 ± 0.026	1.027SerTyr: 1.027 ± 0.034	0.0SerXaa: 0.0 ± 0.0
Thr	8.646ThrAla: 8.646 ± 0.095	0.396ThrCys: 0.396 ± 0.018	3.613ThrAsp: 3.613 ± 0.055	3.018ThrGlu: 3.018 ± 0.053	1.556ThrPhe: 1.556 ± 0.037	6.741ThrGly: 6.741 ± 0.072	1.009ThrHis: 1.009 ± 0.028	1.711ThrIle: 1.711 ± 0.036	0.8ThrLys: 0.8 ± 0.026	5.493ThrLeu: 5.493 ± 0.06	0.918ThrMet: 0.918 ± 0.031	0.887ThrAsn: 0.887 ± 0.031	3.947ThrPro: 3.947 ± 0.058	1.252ThrGln: 1.252 ± 0.028	3.892ThrArg: 3.892 ± 0.052	3.091ThrSer: 3.091 ± 0.06	3.928ThrThr: 3.928 ± 0.075	6.315ThrVal: 6.315 ± 0.07	0.884ThrTrp: 0.884 ± 0.029	1.11ThrTyr: 1.11 ± 0.031	0.0ThrXaa: 0.0 ± 0.0
Val	13.527ValAla: 13.527 ± 0.123	0.682ValCys: 0.682 ± 0.024	6.191ValAsp: 6.191 ± 0.068	5.489ValGlu: 5.489 ± 0.066	2.485ValPhe: 2.485 ± 0.043	8.139ValGly: 8.139 ± 0.077	2.071ValHis: 2.071 ± 0.044	2.688ValIle: 2.688 ± 0.042	1.223ValLys: 1.223 ± 0.033	11.646ValLeu: 11.646 ± 0.096	1.36ValMet: 1.36 ± 0.037	1.422ValAsn: 1.422 ± 0.035	6.008ValPro: 6.008 ± 0.076	2.361ValGln: 2.361 ± 0.044	7.504ValArg: 7.504 ± 0.077	4.416ValSer: 4.416 ± 0.057	6.017ValThr: 6.017 ± 0.077	11.229ValVal: 11.229 ± 0.123	1.11ValTrp: 1.11 ± 0.035	1.463ValTyr: 1.463 ± 0.037	0.0ValXaa: 0.0 ± 0.0
Trp	1.715TrpAla: 1.715 ± 0.039	0.119TrpCys: 0.119 ± 0.009	0.764TrpAsp: 0.764 ± 0.024	0.691TrpGlu: 0.691 ± 0.027	0.514TrpPhe: 0.514 ± 0.023	1.065TrpGly: 1.065 ± 0.028	0.366TrpHis: 0.366 ± 0.018	0.41TrpIle: 0.41 ± 0.016	0.226TrpLys: 0.226 ± 0.014	1.87TrpLeu: 1.87 ± 0.041	0.252TrpMet: 0.252 ± 0.013	0.289TrpAsn: 0.289 ± 0.015	0.805TrpPro: 0.805 ± 0.027	0.529TrpGln: 0.529 ± 0.022	1.328TrpArg: 1.328 ± 0.03	0.967TrpSer: 0.967 ± 0.03	0.963TrpThr: 0.963 ± 0.034	1.156TrpVal: 1.156 ± 0.03	0.343TrpTrp: 0.343 ± 0.014	0.277TrpTyr: 0.277 ± 0.014	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.326TyrAla: 2.326 ± 0.043	0.147TyrCys: 0.147 ± 0.009	1.282TyrAsp: 1.282 ± 0.032	1.033TyrGlu: 1.033 ± 0.031	0.505TyrPhe: 0.505 ± 0.021	1.923TyrGly: 1.923 ± 0.042	0.279TyrHis: 0.279 ± 0.017	0.384TyrIle: 0.384 ± 0.017	0.26TyrLys: 0.26 ± 0.016	1.908TyrLeu: 1.908 ± 0.043	0.194TyrMet: 0.194 ± 0.012	0.285TyrAsn: 0.285 ± 0.015	0.917TyrPro: 0.917 ± 0.028	0.459TyrGln: 0.459 ± 0.017	1.609TyrArg: 1.609 ± 0.033	0.823TyrSer: 0.823 ± 0.027	0.939TyrThr: 0.939 ± 0.026	1.649TyrVal: 1.649 ± 0.036	0.293TyrTrp: 0.293 ± 0.022	0.369TyrTyr: 0.369 ± 0.015	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4219 proteins (1345434 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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