Amino acid dipepetide frequency for Microbacterium sorbitolivorans

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	18.771AlaAla: 18.771 ± 0.232	0.703AlaCys: 0.703 ± 0.033	8.51AlaAsp: 8.51 ± 0.134	8.63AlaGlu: 8.63 ± 0.108	4.068AlaPhe: 4.068 ± 0.075	11.837AlaGly: 11.837 ± 0.126	2.457AlaHis: 2.457 ± 0.055	6.666AlaIle: 6.666 ± 0.095	3.015AlaLys: 3.015 ± 0.066	13.826AlaLeu: 13.826 ± 0.137	2.763AlaMet: 2.763 ± 0.058	2.449AlaAsn: 2.449 ± 0.064	6.172AlaPro: 6.172 ± 0.13	3.705AlaGln: 3.705 ± 0.071	9.093AlaArg: 9.093 ± 0.145	7.379AlaSer: 7.379 ± 0.098	7.393AlaThr: 7.393 ± 0.1	10.102AlaVal: 10.102 ± 0.108	1.945AlaTrp: 1.945 ± 0.051	2.549AlaTyr: 2.549 ± 0.049	0.0AlaXaa: 0.0 ± 0.0
Cys	0.636CysAla: 0.636 ± 0.028	0.06CysCys: 0.06 ± 0.008	0.299CysAsp: 0.299 ± 0.016	0.289CysGlu: 0.289 ± 0.019	0.143CysPhe: 0.143 ± 0.014	0.542CysGly: 0.542 ± 0.028	0.112CysHis: 0.112 ± 0.012	0.215CysIle: 0.215 ± 0.015	0.058CysLys: 0.058 ± 0.008	0.384CysLeu: 0.384 ± 0.02	0.07CysMet: 0.07 ± 0.009	0.102CysAsn: 0.102 ± 0.011	0.255CysPro: 0.255 ± 0.017	0.101CysGln: 0.101 ± 0.011	0.295CysArg: 0.295 ± 0.02	0.346CysSer: 0.346 ± 0.017	0.296CysThr: 0.296 ± 0.018	0.393CysVal: 0.393 ± 0.021	0.062CysTrp: 0.062 ± 0.008	0.12CysTyr: 0.12 ± 0.012	0.0CysXaa: 0.0 ± 0.0
Asp	8.723AspAla: 8.723 ± 0.131	0.19AspCys: 0.19 ± 0.016	4.645AspAsp: 4.645 ± 0.1	5.276AspGlu: 5.276 ± 0.079	1.869AspPhe: 1.869 ± 0.051	6.18AspGly: 6.18 ± 0.112	1.2AspHis: 1.2 ± 0.039	2.827AspIle: 2.827 ± 0.055	1.265AspLys: 1.265 ± 0.039	5.865AspLeu: 5.865 ± 0.089	1.002AspMet: 1.002 ± 0.037	1.21AspAsn: 1.21 ± 0.041	4.572AspPro: 4.572 ± 0.072	1.588AspGln: 1.588 ± 0.044	4.106AspArg: 4.106 ± 0.079	2.639AspSer: 2.639 ± 0.065	2.913AspThr: 2.913 ± 0.065	5.476AspVal: 5.476 ± 0.086	0.937AspTrp: 0.937 ± 0.033	1.415AspTyr: 1.415 ± 0.042	0.0AspXaa: 0.0 ± 0.0
Glu	7.865GluAla: 7.865 ± 0.11	0.255GluCys: 0.255 ± 0.02	2.907GluAsp: 2.907 ± 0.063	3.344GluGlu: 3.344 ± 0.066	1.854GluPhe: 1.854 ± 0.043	4.6GluGly: 4.6 ± 0.079	1.5GluHis: 1.5 ± 0.043	3.454GluIle: 3.454 ± 0.066	1.844GluLys: 1.844 ± 0.056	6.53GluLeu: 6.53 ± 0.089	1.144GluMet: 1.144 ± 0.036	1.529GluAsn: 1.529 ± 0.04	3.075GluPro: 3.075 ± 0.082	2.523GluGln: 2.523 ± 0.052	5.351GluArg: 5.351 ± 0.108	3.019GluSer: 3.019 ± 0.063	3.454GluThr: 3.454 ± 0.067	4.768GluVal: 4.768 ± 0.073	1.033GluTrp: 1.033 ± 0.04	1.246GluTyr: 1.246 ± 0.039	0.0GluXaa: 0.0 ± 0.0
Phe	4.455PheAla: 4.455 ± 0.068	0.167PheCys: 0.167 ± 0.014	2.5PheAsp: 2.5 ± 0.059	1.883PheGlu: 1.883 ± 0.051	1.183PhePhe: 1.183 ± 0.041	3.494PheGly: 3.494 ± 0.06	0.541PheHis: 0.541 ± 0.026	1.31PheIle: 1.31 ± 0.042	0.499PheLys: 0.499 ± 0.026	2.882PheLeu: 2.882 ± 0.062	0.551PheMet: 0.551 ± 0.025	0.707PheAsn: 0.707 ± 0.03	1.409PhePro: 1.409 ± 0.04	0.823PheGln: 0.823 ± 0.026	1.892PheArg: 1.892 ± 0.044	1.898PheSer: 1.898 ± 0.052	2.127PheThr: 2.127 ± 0.049	2.82PheVal: 2.82 ± 0.066	0.548PheTrp: 0.548 ± 0.026	0.726PheTyr: 0.726 ± 0.03	0.0PheXaa: 0.0 ± 0.0
Gly	10.413GlyAla: 10.413 ± 0.133	0.565GlyCys: 0.565 ± 0.027	5.476GlyAsp: 5.476 ± 0.087	5.53GlyGlu: 5.53 ± 0.095	3.294GlyPhe: 3.294 ± 0.067	7.542GlyGly: 7.542 ± 0.138	1.737GlyHis: 1.737 ± 0.05	5.051GlyIle: 5.051 ± 0.073	2.205GlyLys: 2.205 ± 0.062	8.409GlyLeu: 8.409 ± 0.112	1.884GlyMet: 1.884 ± 0.046	1.859GlyAsn: 1.859 ± 0.053	3.346GlyPro: 3.346 ± 0.063	2.368GlyGln: 2.368 ± 0.059	5.936GlyArg: 5.936 ± 0.1	6.771GlySer: 6.771 ± 0.098	5.063GlyThr: 5.063 ± 0.086	7.536GlyVal: 7.536 ± 0.102	1.653GlyTrp: 1.653 ± 0.047	2.306GlyTyr: 2.306 ± 0.061	0.0GlyXaa: 0.0 ± 0.0
His	2.401HisAla: 2.401 ± 0.059	0.085HisCys: 0.085 ± 0.01	1.376HisAsp: 1.376 ± 0.042	1.188HisGlu: 1.188 ± 0.038	0.597HisPhe: 0.597 ± 0.027	1.85HisGly: 1.85 ± 0.051	0.525HisHis: 0.525 ± 0.027	0.767HisIle: 0.767 ± 0.031	0.311HisLys: 0.311 ± 0.019	1.995HisLeu: 1.995 ± 0.044	0.334HisMet: 0.334 ± 0.022	0.402HisAsn: 0.402 ± 0.021	1.275HisPro: 1.275 ± 0.036	0.509HisGln: 0.509 ± 0.025	1.466HisArg: 1.466 ± 0.04	0.92HisSer: 0.92 ± 0.035	1.022HisThr: 1.022 ± 0.038	1.663HisVal: 1.663 ± 0.042	0.279HisTrp: 0.279 ± 0.017	0.435HisTyr: 0.435 ± 0.022	0.0HisXaa: 0.0 ± 0.0
Ile	7.897IleAla: 7.897 ± 0.124	0.255IleCys: 0.255 ± 0.018	4.004IleAsp: 4.004 ± 0.065	3.326IleGlu: 3.326 ± 0.064	1.4IlePhe: 1.4 ± 0.046	4.996IleGly: 4.996 ± 0.085	0.789IleHis: 0.789 ± 0.028	2.05IleIle: 2.05 ± 0.054	0.851IleLys: 0.851 ± 0.031	4.074IleLeu: 4.074 ± 0.081	0.762IleMet: 0.762 ± 0.032	1.037IleAsn: 1.037 ± 0.037	2.603IlePro: 2.603 ± 0.056	1.098IleGln: 1.098 ± 0.042	3.029IleArg: 3.029 ± 0.062	2.574IleSer: 2.574 ± 0.063	2.943IleThr: 2.943 ± 0.064	5.079IleVal: 5.079 ± 0.08	0.558IleTrp: 0.558 ± 0.026	0.855IleTyr: 0.855 ± 0.032	0.0IleXaa: 0.0 ± 0.0
Lys	2.579LysAla: 2.579 ± 0.056	0.068LysCys: 0.068 ± 0.009	1.158LysAsp: 1.158 ± 0.039	0.969LysGlu: 0.969 ± 0.039	0.584LysPhe: 0.584 ± 0.025	1.659LysGly: 1.659 ± 0.049	0.513LysHis: 0.513 ± 0.025	1.219LysIle: 1.219 ± 0.047	1.048LysLys: 1.048 ± 0.045	2.177LysLeu: 2.177 ± 0.053	0.506LysMet: 0.506 ± 0.024	0.711LysAsn: 0.711 ± 0.026	1.279LysPro: 1.279 ± 0.045	0.818LysGln: 0.818 ± 0.031	1.718LysArg: 1.718 ± 0.047	1.254LysSer: 1.254 ± 0.04	1.464LysThr: 1.464 ± 0.042	1.746LysVal: 1.746 ± 0.057	0.323LysTrp: 0.323 ± 0.019	0.465LysTyr: 0.465 ± 0.024	0.0LysXaa: 0.0 ± 0.0
Leu	14.255LeuAla: 14.255 ± 0.173	0.451LeuCys: 0.451 ± 0.023	6.51LeuAsp: 6.51 ± 0.104	5.592LeuGlu: 5.592 ± 0.095	2.96LeuPhe: 2.96 ± 0.066	8.756LeuGly: 8.756 ± 0.12	1.631LeuHis: 1.631 ± 0.045	4.685LeuIle: 4.685 ± 0.097	1.806LeuLys: 1.806 ± 0.05	9.068LeuLeu: 9.068 ± 0.123	1.753LeuMet: 1.753 ± 0.041	1.929LeuAsn: 1.929 ± 0.049	5.105LeuPro: 5.105 ± 0.077	2.32LeuGln: 2.32 ± 0.055	6.672LeuArg: 6.672 ± 0.101	5.772LeuSer: 5.772 ± 0.095	5.954LeuThr: 5.954 ± 0.077	8.913LeuVal: 8.913 ± 0.107	1.272LeuTrp: 1.272 ± 0.04	1.656LeuTyr: 1.656 ± 0.044	0.0LeuXaa: 0.0 ± 0.0
Met	2.169MetAla: 2.169 ± 0.053	0.09MetCys: 0.09 ± 0.01	0.834MetAsp: 0.834 ± 0.031	0.651MetGlu: 0.651 ± 0.027	0.626MetPhe: 0.626 ± 0.027	1.484MetGly: 1.484 ± 0.045	0.382MetHis: 0.382 ± 0.021	1.043MetIle: 1.043 ± 0.037	0.521MetLys: 0.521 ± 0.025	1.999MetLeu: 1.999 ± 0.05	0.417MetMet: 0.417 ± 0.024	0.543MetAsn: 0.543 ± 0.022	1.109MetPro: 1.109 ± 0.034	0.553MetGln: 0.553 ± 0.025	1.477MetArg: 1.477 ± 0.04	1.609MetSer: 1.609 ± 0.047	1.781MetThr: 1.781 ± 0.037	1.357MetVal: 1.357 ± 0.039	0.254MetTrp: 0.254 ± 0.019	0.326MetTyr: 0.326 ± 0.022	0.0MetXaa: 0.0 ± 0.0
Asn	2.693AsnAla: 2.693 ± 0.073	0.095AsnCys: 0.095 ± 0.01	1.452AsnAsp: 1.452 ± 0.045	1.263AsnGlu: 1.263 ± 0.038	0.679AsnPhe: 0.679 ± 0.028	2.079AsnGly: 2.079 ± 0.061	0.418AsnHis: 0.418 ± 0.023	0.951AsnIle: 0.951 ± 0.033	0.485AsnLys: 0.485 ± 0.023	2.012AsnLeu: 2.012 ± 0.048	0.393AsnMet: 0.393 ± 0.021	0.544AsnAsn: 0.544 ± 0.026	1.57AsnPro: 1.57 ± 0.043	0.578AsnGln: 0.578 ± 0.028	1.362AsnArg: 1.362 ± 0.055	1.07AsnSer: 1.07 ± 0.038	1.247AsnThr: 1.247 ± 0.041	1.808AsnVal: 1.808 ± 0.048	0.318AsnTrp: 0.318 ± 0.019	0.543AsnTyr: 0.543 ± 0.022	0.0AsnXaa: 0.0 ± 0.0
Pro	6.799ProAla: 6.799 ± 0.121	0.184ProCys: 0.184 ± 0.015	3.565ProAsp: 3.565 ± 0.069	3.92ProGlu: 3.92 ± 0.075	1.722ProPhe: 1.722 ± 0.045	4.654ProGly: 4.654 ± 0.078	1.07ProHis: 1.07 ± 0.032	2.186ProIle: 2.186 ± 0.048	1.119ProLys: 1.119 ± 0.037	4.587ProLeu: 4.587 ± 0.064	0.863ProMet: 0.863 ± 0.031	1.134ProAsn: 1.134 ± 0.04	1.768ProPro: 1.768 ± 0.057	1.488ProGln: 1.488 ± 0.041	3.253ProArg: 3.253 ± 0.071	2.944ProSer: 2.944 ± 0.062	3.291ProThr: 3.291 ± 0.095	4.318ProVal: 4.318 ± 0.074	0.877ProTrp: 0.877 ± 0.031	1.068ProTyr: 1.068 ± 0.034	0.0ProXaa: 0.0 ± 0.0
Gln	3.444GlnAla: 3.444 ± 0.065	0.099GlnCys: 0.099 ± 0.011	1.309GlnAsp: 1.309 ± 0.045	1.336GlnGlu: 1.336 ± 0.042	0.874GlnPhe: 0.874 ± 0.029	2.116GlnGly: 2.116 ± 0.051	0.584GlnHis: 0.584 ± 0.026	1.692GlnIle: 1.692 ± 0.042	0.825GlnLys: 0.825 ± 0.03	3.076GlnLeu: 3.076 ± 0.073	0.596GlnMet: 0.596 ± 0.024	0.795GlnAsn: 0.795 ± 0.033	1.347GlnPro: 1.347 ± 0.041	1.186GlnGln: 1.186 ± 0.039	2.212GlnArg: 2.212 ± 0.062	1.428GlnSer: 1.428 ± 0.042	1.585GlnThr: 1.585 ± 0.04	2.253GlnVal: 2.253 ± 0.049	0.4GlnTrp: 0.4 ± 0.024	0.645GlnTyr: 0.645 ± 0.03	0.0GlnXaa: 0.0 ± 0.0
Arg	8.937ArgAla: 8.937 ± 0.141	0.27ArgCys: 0.27 ± 0.018	4.465ArgAsp: 4.465 ± 0.077	4.794ArgGlu: 4.794 ± 0.092	2.275ArgPhe: 2.275 ± 0.053	5.748ArgGly: 5.748 ± 0.105	1.418ArgHis: 1.418 ± 0.038	3.907ArgIle: 3.907 ± 0.066	1.523ArgLys: 1.523 ± 0.037	6.48ArgLeu: 6.48 ± 0.104	1.618ArgMet: 1.618 ± 0.042	1.269ArgAsn: 1.269 ± 0.039	3.13ArgPro: 3.13 ± 0.071	2.027ArgGln: 2.027 ± 0.054	6.133ArgArg: 6.133 ± 0.129	3.724ArgSer: 3.724 ± 0.06	3.943ArgThr: 3.943 ± 0.08	5.939ArgVal: 5.939 ± 0.104	1.154ArgTrp: 1.154 ± 0.037	1.486ArgTyr: 1.486 ± 0.044	0.0ArgXaa: 0.0 ± 0.0
Ser	7.255SerAla: 7.255 ± 0.111	0.313SerCys: 0.313 ± 0.021	3.552SerAsp: 3.552 ± 0.062	3.186SerGlu: 3.186 ± 0.064	2.102SerPhe: 2.102 ± 0.053	5.809SerGly: 5.809 ± 0.088	1.106SerHis: 1.106 ± 0.038	2.747SerIle: 2.747 ± 0.051	1.193SerLys: 1.193 ± 0.039	5.726SerLeu: 5.726 ± 0.082	1.242SerMet: 1.242 ± 0.04	1.225SerAsn: 1.225 ± 0.036	2.895SerPro: 2.895 ± 0.068	1.446SerGln: 1.446 ± 0.041	3.88SerArg: 3.88 ± 0.069	3.579SerSer: 3.579 ± 0.074	3.529SerThr: 3.529 ± 0.064	4.659SerVal: 4.659 ± 0.074	1.046SerTrp: 1.046 ± 0.036	1.24SerTyr: 1.24 ± 0.044	0.0SerXaa: 0.0 ± 0.0
Thr	7.271ThrAla: 7.271 ± 0.107	0.277ThrCys: 0.277 ± 0.02	3.568ThrAsp: 3.568 ± 0.068	3.22ThrGlu: 3.22 ± 0.07	1.97ThrPhe: 1.97 ± 0.051	5.65ThrGly: 5.65 ± 0.093	1.266ThrHis: 1.266 ± 0.041	3.177ThrIle: 3.177 ± 0.066	1.233ThrLys: 1.233 ± 0.038	5.911ThrLeu: 5.911 ± 0.073	1.058ThrMet: 1.058 ± 0.037	1.297ThrAsn: 1.297 ± 0.039	3.713ThrPro: 3.713 ± 0.085	1.514ThrGln: 1.514 ± 0.042	3.737ThrArg: 3.737 ± 0.078	3.571ThrSer: 3.571 ± 0.073	3.735ThrThr: 3.735 ± 0.082	5.164ThrVal: 5.164 ± 0.087	0.929ThrTrp: 0.929 ± 0.032	1.321ThrTyr: 1.321 ± 0.041	0.0ThrXaa: 0.0 ± 0.0
Val	11.287ValAla: 11.287 ± 0.135	0.436ValCys: 0.436 ± 0.022	5.433ValAsp: 5.433 ± 0.079	4.871ValGlu: 4.871 ± 0.076	2.906ValPhe: 2.906 ± 0.057	6.752ValGly: 6.752 ± 0.095	1.507ValHis: 1.507 ± 0.041	4.598ValIle: 4.598 ± 0.088	1.748ValLys: 1.748 ± 0.051	8.276ValLeu: 8.276 ± 0.1	1.6ValMet: 1.6 ± 0.049	1.809ValAsn: 1.809 ± 0.052	4.442ValPro: 4.442 ± 0.072	1.965ValGln: 1.965 ± 0.052	5.66ValArg: 5.66 ± 0.094	5.075ValSer: 5.075 ± 0.083	5.731ValThr: 5.731 ± 0.098	7.919ValVal: 7.919 ± 0.117	1.123ValTrp: 1.123 ± 0.035	1.554ValTyr: 1.554 ± 0.048	0.0ValXaa: 0.0 ± 0.0
Trp	1.587TrpAla: 1.587 ± 0.041	0.111TrpCys: 0.111 ± 0.01	0.878TrpAsp: 0.878 ± 0.03	0.68TrpGlu: 0.68 ± 0.032	0.595TrpPhe: 0.595 ± 0.026	1.183TrpGly: 1.183 ± 0.04	0.357TrpHis: 0.357 ± 0.021	0.889TrpIle: 0.889 ± 0.032	0.332TrpLys: 0.332 ± 0.02	1.691TrpLeu: 1.691 ± 0.054	0.331TrpMet: 0.331 ± 0.017	0.508TrpAsn: 0.508 ± 0.026	0.673TrpPro: 0.673 ± 0.031	0.614TrpGln: 0.614 ± 0.026	1.352TrpArg: 1.352 ± 0.044	0.965TrpSer: 0.965 ± 0.037	0.921TrpThr: 0.921 ± 0.039	1.062TrpVal: 1.062 ± 0.039	0.363TrpTrp: 0.363 ± 0.022	0.299TrpTyr: 0.299 ± 0.017	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.596TyrAla: 2.596 ± 0.057	0.104TyrCys: 0.104 ± 0.012	1.456TyrAsp: 1.456 ± 0.045	1.35TyrGlu: 1.35 ± 0.048	0.713TyrPhe: 0.713 ± 0.029	2.014TyrGly: 2.014 ± 0.059	0.286TyrHis: 0.286 ± 0.02	0.745TyrIle: 0.745 ± 0.029	0.378TyrLys: 0.378 ± 0.023	2.088TyrLeu: 2.088 ± 0.051	0.34TyrMet: 0.34 ± 0.02	0.5TyrAsn: 0.5 ± 0.024	1.073TyrPro: 1.073 ± 0.036	0.577TyrGln: 0.577 ± 0.032	1.617TyrArg: 1.617 ± 0.048	1.196TyrSer: 1.196 ± 0.045	1.19TyrThr: 1.19 ± 0.04	1.718TyrVal: 1.718 ± 0.045	0.315TyrTrp: 0.315 ± 0.021	0.455TyrTyr: 0.455 ± 0.023	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2725 proteins (909936 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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