Amino acid dipepetide frequency for Paenibacillus sp. 597

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	8.087AlaAla: 8.087 ± 0.079	0.689AlaCys: 0.689 ± 0.018	4.063AlaAsp: 4.063 ± 0.045	4.925AlaGlu: 4.925 ± 0.056	3.339AlaPhe: 3.339 ± 0.039	6.036AlaGly: 6.036 ± 0.056	1.375AlaHis: 1.375 ± 0.024	5.656AlaIle: 5.656 ± 0.051	4.523AlaLys: 4.523 ± 0.053	7.809AlaLeu: 7.809 ± 0.059	2.263AlaMet: 2.263 ± 0.031	3.087AlaAsn: 3.087 ± 0.041	2.782AlaPro: 2.782 ± 0.036	2.763AlaGln: 2.763 ± 0.039	3.025AlaArg: 3.025 ± 0.042	5.353AlaSer: 5.353 ± 0.059	4.024AlaThr: 4.024 ± 0.053	5.883AlaVal: 5.883 ± 0.057	0.985AlaTrp: 0.985 ± 0.021	2.787AlaTyr: 2.787 ± 0.037	0.0AlaXaa: 0.0 ± 0.0
Cys	0.492CysAla: 0.492 ± 0.014	0.1CysCys: 0.1 ± 0.007	0.353CysAsp: 0.353 ± 0.013	0.426CysGlu: 0.426 ± 0.016	0.331CysPhe: 0.331 ± 0.013	0.649CysGly: 0.649 ± 0.017	0.19CysHis: 0.19 ± 0.01	0.476CysIle: 0.476 ± 0.014	0.327CysLys: 0.327 ± 0.012	0.771CysLeu: 0.771 ± 0.019	0.222CysMet: 0.222 ± 0.009	0.254CysAsn: 0.254 ± 0.01	0.305CysPro: 0.305 ± 0.01	0.236CysGln: 0.236 ± 0.009	0.356CysArg: 0.356 ± 0.011	0.594CysSer: 0.594 ± 0.017	0.42CysThr: 0.42 ± 0.012	0.455CysVal: 0.455 ± 0.012	0.104CysTrp: 0.104 ± 0.007	0.267CysTyr: 0.267 ± 0.01	0.0CysXaa: 0.0 ± 0.0
Asp	3.944AspAla: 3.944 ± 0.043	0.364AspCys: 0.364 ± 0.012	2.35AspAsp: 2.35 ± 0.038	3.52AspGlu: 3.52 ± 0.041	2.231AspPhe: 2.231 ± 0.03	3.894AspGly: 3.894 ± 0.052	1.158AspHis: 1.158 ± 0.022	3.503AspIle: 3.503 ± 0.038	2.884AspLys: 2.884 ± 0.033	4.917AspLeu: 4.917 ± 0.049	1.35AspMet: 1.35 ± 0.023	1.907AspAsn: 1.907 ± 0.035	2.254AspPro: 2.254 ± 0.034	2.09AspGln: 2.09 ± 0.03	2.439AspArg: 2.439 ± 0.031	2.903AspSer: 2.903 ± 0.038	2.54AspThr: 2.54 ± 0.032	3.676AspVal: 3.676 ± 0.04	0.896AspTrp: 0.896 ± 0.02	2.092AspTyr: 2.092 ± 0.029	0.0AspXaa: 0.0 ± 0.0
Glu	5.442GluAla: 5.442 ± 0.052	0.354GluCys: 0.354 ± 0.012	2.894GluAsp: 2.894 ± 0.037	4.666GluGlu: 4.666 ± 0.059	2.155GluPhe: 2.155 ± 0.031	4.05GluGly: 4.05 ± 0.05	1.468GluHis: 1.468 ± 0.027	4.209GluIle: 4.209 ± 0.047	3.906GluLys: 3.906 ± 0.04	6.776GluLeu: 6.776 ± 0.073	1.886GluMet: 1.886 ± 0.027	2.437GluAsn: 2.437 ± 0.032	2.007GluPro: 2.007 ± 0.028	3.506GluGln: 3.506 ± 0.054	3.337GluArg: 3.337 ± 0.049	3.511GluSer: 3.511 ± 0.044	3.293GluThr: 3.293 ± 0.038	4.23GluVal: 4.23 ± 0.044	0.893GluTrp: 0.893 ± 0.02	1.797GluTyr: 1.797 ± 0.03	0.0GluXaa: 0.0 ± 0.0
Phe	3.221PheAla: 3.221 ± 0.036	0.339PheCys: 0.339 ± 0.012	2.342PheAsp: 2.342 ± 0.033	2.429PheGlu: 2.429 ± 0.033	1.941PhePhe: 1.941 ± 0.032	3.137PheGly: 3.137 ± 0.043	1.024PheHis: 1.024 ± 0.016	3.213PheIle: 3.213 ± 0.043	2.156PheLys: 2.156 ± 0.035	4.072PheLeu: 4.072 ± 0.058	1.176PheMet: 1.176 ± 0.025	1.739PheAsn: 1.739 ± 0.026	1.703PhePro: 1.703 ± 0.027	1.64PheGln: 1.64 ± 0.028	1.895PheArg: 1.895 ± 0.031	2.937PheSer: 2.937 ± 0.035	2.657PheThr: 2.657 ± 0.034	3.022PheVal: 3.022 ± 0.037	0.532PheTrp: 0.532 ± 0.016	1.574PheTyr: 1.574 ± 0.027	0.0PheXaa: 0.0 ± 0.0
Gly	5.32GlyAla: 5.32 ± 0.067	0.68GlyCys: 0.68 ± 0.017	3.36GlyAsp: 3.36 ± 0.049	4.067GlyGlu: 4.067 ± 0.045	3.214GlyPhe: 3.214 ± 0.04	5.009GlyGly: 5.009 ± 0.065	1.554GlyHis: 1.554 ± 0.03	5.566GlyIle: 5.566 ± 0.052	4.473GlyLys: 4.473 ± 0.053	6.822GlyLeu: 6.822 ± 0.06	2.194GlyMet: 2.194 ± 0.027	2.85GlyAsn: 2.85 ± 0.041	1.877GlyPro: 1.877 ± 0.027	2.654GlyGln: 2.654 ± 0.035	2.973GlyArg: 2.973 ± 0.037	4.697GlySer: 4.697 ± 0.053	4.595GlyThr: 4.595 ± 0.055	5.121GlyVal: 5.121 ± 0.05	1.102GlyTrp: 1.102 ± 0.025	2.868GlyTyr: 2.868 ± 0.032	0.0GlyXaa: 0.0 ± 0.0
His	1.623HisAla: 1.623 ± 0.024	0.183HisCys: 0.183 ± 0.009	0.989HisAsp: 0.989 ± 0.022	1.295HisGlu: 1.295 ± 0.024	1.178HisPhe: 1.178 ± 0.02	1.455HisGly: 1.455 ± 0.026	0.662HisHis: 0.662 ± 0.019	1.526HisIle: 1.526 ± 0.029	0.925HisLys: 0.925 ± 0.019	2.228HisLeu: 2.228 ± 0.036	0.607HisMet: 0.607 ± 0.014	0.764HisAsn: 0.764 ± 0.018	1.157HisPro: 1.157 ± 0.025	0.874HisGln: 0.874 ± 0.018	1.041HisArg: 1.041 ± 0.022	1.232HisSer: 1.232 ± 0.021	1.093HisThr: 1.093 ± 0.021	1.516HisVal: 1.516 ± 0.026	0.342HisTrp: 0.342 ± 0.013	0.954HisTyr: 0.954 ± 0.022	0.0HisXaa: 0.0 ± 0.0
Ile	5.834IleAla: 5.834 ± 0.055	0.644IleCys: 0.644 ± 0.015	3.734IleAsp: 3.734 ± 0.039	4.304IleGlu: 4.304 ± 0.048	2.607IlePhe: 2.607 ± 0.04	5.279IleGly: 5.279 ± 0.058	1.618IleHis: 1.618 ± 0.029	4.571IleIle: 4.571 ± 0.054	3.255IleLys: 3.255 ± 0.042	6.245IleLeu: 6.245 ± 0.06	1.71IleMet: 1.71 ± 0.03	2.676IleAsn: 2.676 ± 0.036	3.245IlePro: 3.245 ± 0.039	2.846IleGln: 2.846 ± 0.033	3.553IleArg: 3.553 ± 0.038	4.944IleSer: 4.944 ± 0.048	4.254IleThr: 4.254 ± 0.045	5.2IleVal: 5.2 ± 0.056	0.793IleTrp: 0.793 ± 0.019	2.282IleTyr: 2.282 ± 0.031	0.0IleXaa: 0.0 ± 0.0
Lys	4.487LysAla: 4.487 ± 0.048	0.253LysCys: 0.253 ± 0.009	3.207LysAsp: 3.207 ± 0.043	4.332LysGlu: 4.332 ± 0.047	1.813LysPhe: 1.813 ± 0.026	3.769LysGly: 3.769 ± 0.043	1.189LysHis: 1.189 ± 0.021	3.35LysIle: 3.35 ± 0.04	3.572LysLys: 3.572 ± 0.055	5.753LysLeu: 5.753 ± 0.056	1.819LysMet: 1.819 ± 0.03	2.259LysAsn: 2.259 ± 0.031	2.306LysPro: 2.306 ± 0.032	2.762LysGln: 2.762 ± 0.039	2.611LysArg: 2.611 ± 0.037	3.322LysSer: 3.322 ± 0.039	2.976LysThr: 2.976 ± 0.04	3.902LysVal: 3.902 ± 0.045	0.8LysTrp: 0.8 ± 0.017	1.902LysTyr: 1.902 ± 0.036	0.0LysXaa: 0.0 ± 0.0
Leu	7.931LeuAla: 7.931 ± 0.065	0.787LeuCys: 0.787 ± 0.018	5.026LeuAsp: 5.026 ± 0.047	5.791LeuGlu: 5.791 ± 0.059	4.633LeuPhe: 4.633 ± 0.055	6.573LeuGly: 6.573 ± 0.058	2.199LeuHis: 2.199 ± 0.036	6.785LeuIle: 6.785 ± 0.06	5.477LeuLys: 5.477 ± 0.046	10.714LeuLeu: 10.714 ± 0.101	2.644LeuMet: 2.644 ± 0.034	4.018LeuAsn: 4.018 ± 0.045	4.567LeuPro: 4.567 ± 0.047	4.439LeuGln: 4.439 ± 0.05	4.561LeuArg: 4.561 ± 0.054	7.218LeuSer: 7.218 ± 0.055	6.01LeuThr: 6.01 ± 0.047	6.411LeuVal: 6.411 ± 0.056	1.084LeuTrp: 1.084 ± 0.02	3.24LeuTyr: 3.24 ± 0.042	0.0LeuXaa: 0.0 ± 0.0
Met	2.144MetAla: 2.144 ± 0.029	0.151MetCys: 0.151 ± 0.008	1.538MetAsp: 1.538 ± 0.025	1.732MetGlu: 1.732 ± 0.025	1.126MetPhe: 1.126 ± 0.021	1.74MetGly: 1.74 ± 0.033	0.508MetHis: 0.508 ± 0.016	2.048MetIle: 2.048 ± 0.027	2.164MetLys: 2.164 ± 0.029	2.961MetLeu: 2.961 ± 0.034	0.907MetMet: 0.907 ± 0.022	1.562MetAsn: 1.562 ± 0.023	1.174MetPro: 1.174 ± 0.023	1.077MetGln: 1.077 ± 0.024	1.286MetArg: 1.286 ± 0.023	1.884MetSer: 1.884 ± 0.033	1.754MetThr: 1.754 ± 0.028	1.814MetVal: 1.814 ± 0.028	0.28MetTrp: 0.28 ± 0.011	0.845MetTyr: 0.845 ± 0.017	0.0MetXaa: 0.0 ± 0.0
Asn	2.924AsnAla: 2.924 ± 0.045	0.259AsnCys: 0.259 ± 0.011	2.081AsnAsp: 2.081 ± 0.035	2.63AsnGlu: 2.63 ± 0.032	1.555AsnPhe: 1.555 ± 0.026	3.274AsnGly: 3.274 ± 0.039	0.931AsnHis: 0.931 ± 0.021	2.518AsnIle: 2.518 ± 0.035	2.423AsnLys: 2.423 ± 0.046	3.695AsnLeu: 3.695 ± 0.037	1.109AsnMet: 1.109 ± 0.023	1.925AsnAsn: 1.925 ± 0.039	2.158AsnPro: 2.158 ± 0.027	1.791AsnGln: 1.791 ± 0.028	2.013AsnArg: 2.013 ± 0.03	2.428AsnSer: 2.428 ± 0.039	2.266AsnThr: 2.266 ± 0.032	2.904AsnVal: 2.904 ± 0.037	0.648AsnTrp: 0.648 ± 0.017	1.579AsnTyr: 1.579 ± 0.03	0.0AsnXaa: 0.0 ± 0.0
Pro	3.245ProAla: 3.245 ± 0.043	0.225ProCys: 0.225 ± 0.01	2.373ProAsp: 2.373 ± 0.028	2.919ProGlu: 2.919 ± 0.031	1.93ProPhe: 1.93 ± 0.028	2.73ProGly: 2.73 ± 0.033	0.943ProHis: 0.943 ± 0.021	2.79ProIle: 2.79 ± 0.035	1.926ProLys: 1.926 ± 0.031	3.982ProLeu: 3.982 ± 0.042	1.053ProMet: 1.053 ± 0.021	1.753ProAsn: 1.753 ± 0.028	1.209ProPro: 1.209 ± 0.025	1.446ProGln: 1.446 ± 0.023	1.314ProArg: 1.314 ± 0.025	2.725ProSer: 2.725 ± 0.034	2.307ProThr: 2.307 ± 0.037	3.112ProVal: 3.112 ± 0.036	0.529ProTrp: 0.529 ± 0.015	1.55ProTyr: 1.55 ± 0.023	0.0ProXaa: 0.0 ± 0.0
Gln	3.466GlnAla: 3.466 ± 0.046	0.203GlnCys: 0.203 ± 0.009	1.889GlnAsp: 1.889 ± 0.029	2.654GlnGlu: 2.654 ± 0.043	1.705GlnPhe: 1.705 ± 0.027	2.663GlnGly: 2.663 ± 0.035	0.887GlnHis: 0.887 ± 0.022	2.787GlnIle: 2.787 ± 0.029	2.172GlnLys: 2.172 ± 0.031	4.507GlnLeu: 4.507 ± 0.056	1.316GlnMet: 1.316 ± 0.023	1.531GlnAsn: 1.531 ± 0.026	1.539GlnPro: 1.539 ± 0.029	1.966GlnGln: 1.966 ± 0.044	1.782GlnArg: 1.782 ± 0.031	2.505GlnSer: 2.505 ± 0.032	2.293GlnThr: 2.293 ± 0.034	2.882GlnVal: 2.882 ± 0.035	0.529GlnTrp: 0.529 ± 0.015	1.332GlnTyr: 1.332 ± 0.022	0.0GlnXaa: 0.0 ± 0.0
Arg	2.955ArgAla: 2.955 ± 0.039	0.304ArgCys: 0.304 ± 0.012	2.13ArgAsp: 2.13 ± 0.03	3.112ArgGlu: 3.112 ± 0.044	2.074ArgPhe: 2.074 ± 0.031	2.655ArgGly: 2.655 ± 0.038	0.922ArgHis: 0.922 ± 0.017	3.534ArgIle: 3.534 ± 0.04	2.852ArgLys: 2.852 ± 0.035	4.49ArgLeu: 4.49 ± 0.056	1.585ArgMet: 1.585 ± 0.025	1.998ArgAsn: 1.998 ± 0.032	1.552ArgPro: 1.552 ± 0.026	1.761ArgGln: 1.761 ± 0.029	2.122ArgArg: 2.122 ± 0.034	2.868ArgSer: 2.868 ± 0.04	2.493ArgThr: 2.493 ± 0.037	2.97ArgVal: 2.97 ± 0.042	0.627ArgTrp: 0.627 ± 0.016	1.705ArgTyr: 1.705 ± 0.029	0.0ArgXaa: 0.0 ± 0.0
Ser	4.852SerAla: 4.852 ± 0.044	0.441SerCys: 0.441 ± 0.012	3.17SerAsp: 3.17 ± 0.035	3.823SerGlu: 3.823 ± 0.043	3.177SerPhe: 3.177 ± 0.039	5.305SerGly: 5.305 ± 0.049	1.319SerHis: 1.319 ± 0.025	4.611SerIle: 4.611 ± 0.044	3.613SerLys: 3.613 ± 0.04	6.758SerLeu: 6.758 ± 0.051	1.9SerMet: 1.9 ± 0.027	2.686SerAsn: 2.686 ± 0.039	2.571SerPro: 2.571 ± 0.033	2.295SerGln: 2.295 ± 0.027	2.761SerArg: 2.761 ± 0.038	4.948SerSer: 4.948 ± 0.059	3.689SerThr: 3.689 ± 0.045	4.595SerVal: 4.595 ± 0.046	0.896SerTrp: 0.896 ± 0.021	2.508SerTyr: 2.508 ± 0.034	0.0SerXaa: 0.0 ± 0.0
Thr	4.73ThrAla: 4.73 ± 0.057	0.363ThrCys: 0.363 ± 0.012	3.018ThrAsp: 3.018 ± 0.038	3.157ThrGlu: 3.157 ± 0.042	2.577ThrPhe: 2.577 ± 0.035	4.523ThrGly: 4.523 ± 0.065	1.066ThrHis: 1.066 ± 0.021	4.197ThrIle: 4.197 ± 0.041	2.9ThrLys: 2.9 ± 0.039	5.736ThrLeu: 5.736 ± 0.05	1.486ThrMet: 1.486 ± 0.026	2.466ThrAsn: 2.466 ± 0.036	2.677ThrPro: 2.677 ± 0.036	1.803ThrGln: 1.803 ± 0.026	2.138ThrArg: 2.138 ± 0.031	3.84ThrSer: 3.84 ± 0.05	3.401ThrThr: 3.401 ± 0.05	4.37ThrVal: 4.37 ± 0.062	0.741ThrTrp: 0.741 ± 0.019	2.209ThrTyr: 2.209 ± 0.032	0.0ThrXaa: 0.0 ± 0.0
Val	5.178ValAla: 5.178 ± 0.052	0.591ValCys: 0.591 ± 0.017	3.788ValAsp: 3.788 ± 0.041	4.007ValGlu: 4.007 ± 0.038	2.89ValPhe: 2.89 ± 0.038	4.705ValGly: 4.705 ± 0.049	1.491ValHis: 1.491 ± 0.026	5.147ValIle: 5.147 ± 0.052	4.156ValLys: 4.156 ± 0.046	6.929ValLeu: 6.929 ± 0.054	2.02ValMet: 2.02 ± 0.027	2.964ValAsn: 2.964 ± 0.036	3.01ValPro: 3.01 ± 0.036	2.725ValGln: 2.725 ± 0.037	3.064ValArg: 3.064 ± 0.039	4.881ValSer: 4.881 ± 0.053	4.568ValThr: 4.568 ± 0.061	4.934ValVal: 4.934 ± 0.046	0.861ValTrp: 0.861 ± 0.019	2.451ValTyr: 2.451 ± 0.034	0.0ValXaa: 0.0 ± 0.0
Trp	0.864TrpAla: 0.864 ± 0.021	0.111TrpCys: 0.111 ± 0.006	0.742TrpAsp: 0.742 ± 0.015	0.779TrpGlu: 0.779 ± 0.018	0.588TrpPhe: 0.588 ± 0.016	0.894TrpGly: 0.894 ± 0.021	0.339TrpHis: 0.339 ± 0.012	0.947TrpIle: 0.947 ± 0.022	0.841TrpLys: 0.841 ± 0.02	1.432TrpLeu: 1.432 ± 0.025	0.452TrpMet: 0.452 ± 0.013	0.726TrpAsn: 0.726 ± 0.018	0.388TrpPro: 0.388 ± 0.014	0.575TrpGln: 0.575 ± 0.018	0.582TrpArg: 0.582 ± 0.016	0.864TrpSer: 0.864 ± 0.021	0.72TrpThr: 0.72 ± 0.019	0.866TrpVal: 0.866 ± 0.022	0.193TrpTrp: 0.193 ± 0.009	0.439TrpTyr: 0.439 ± 0.015	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.715TyrAla: 2.715 ± 0.031	0.287TyrCys: 0.287 ± 0.011	1.866TyrAsp: 1.866 ± 0.033	2.248TyrGlu: 2.248 ± 0.037	1.684TyrPhe: 1.684 ± 0.027	2.654TyrGly: 2.654 ± 0.029	0.803TyrHis: 0.803 ± 0.018	2.16TyrIle: 2.16 ± 0.032	1.841TyrLys: 1.841 ± 0.028	3.511TyrLeu: 3.511 ± 0.04	0.996TyrMet: 0.996 ± 0.02	1.513TyrAsn: 1.513 ± 0.03	1.578TyrPro: 1.578 ± 0.027	1.361TyrGln: 1.361 ± 0.026	1.854TyrArg: 1.854 ± 0.031	2.265TyrSer: 2.265 ± 0.031	2.045TyrThr: 2.045 ± 0.03	2.495TyrVal: 2.495 ± 0.03	0.509TyrTrp: 0.509 ± 0.016	1.426TyrTyr: 1.426 ± 0.028	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 7604 proteins (2559972 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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