Amino acid dipepetide frequency for Halioglobus sediminis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	14.15AlaAla: 14.15 ± 0.162	1.238AlaCys: 1.238 ± 0.031	6.646AlaAsp: 6.646 ± 0.076	7.209AlaGlu: 7.209 ± 0.086	3.515AlaPhe: 3.515 ± 0.061	10.061AlaGly: 10.061 ± 0.098	1.96AlaHis: 1.96 ± 0.043	5.412AlaIle: 5.412 ± 0.067	2.48AlaLys: 2.48 ± 0.051	12.387AlaLeu: 12.387 ± 0.126	3.102AlaMet: 3.102 ± 0.054	2.925AlaAsn: 2.925 ± 0.05	4.517AlaPro: 4.517 ± 0.064	4.075AlaGln: 4.075 ± 0.065	7.747AlaArg: 7.747 ± 0.097	6.423AlaSer: 6.423 ± 0.073	5.187AlaThr: 5.187 ± 0.063	7.717AlaVal: 7.717 ± 0.078	1.414AlaTrp: 1.414 ± 0.037	2.649AlaTyr: 2.649 ± 0.054	0.0AlaXaa: 0.0 ± 0.0
Cys	1.114CysAla: 1.114 ± 0.029	0.161CysCys: 0.161 ± 0.008	0.621CysAsp: 0.621 ± 0.022	0.634CysGlu: 0.634 ± 0.022	0.381CysPhe: 0.381 ± 0.017	1.03CysGly: 1.03 ± 0.029	0.339CysHis: 0.339 ± 0.024	0.486CysIle: 0.486 ± 0.021	0.287CysLys: 0.287 ± 0.016	1.067CysLeu: 1.067 ± 0.028	0.212CysMet: 0.212 ± 0.012	0.315CysAsn: 0.315 ± 0.017	0.592CysPro: 0.592 ± 0.022	0.408CysGln: 0.408 ± 0.018	0.696CysArg: 0.696 ± 0.024	0.711CysSer: 0.711 ± 0.024	0.463CysThr: 0.463 ± 0.019	0.627CysVal: 0.627 ± 0.022	0.159CysTrp: 0.159 ± 0.012	0.301CysTyr: 0.301 ± 0.015	0.0CysXaa: 0.0 ± 0.0
Asp	5.836AspAla: 5.836 ± 0.074	0.695AspCys: 0.695 ± 0.025	3.337AspAsp: 3.337 ± 0.066	3.901AspGlu: 3.901 ± 0.057	2.378AspPhe: 2.378 ± 0.052	4.724AspGly: 4.724 ± 0.088	1.221AspHis: 1.221 ± 0.035	3.603AspIle: 3.603 ± 0.059	1.999AspLys: 1.999 ± 0.044	5.769AspLeu: 5.769 ± 0.083	1.571AspMet: 1.571 ± 0.038	2.007AspAsn: 2.007 ± 0.043	3.153AspPro: 3.153 ± 0.054	2.178AspGln: 2.178 ± 0.039	3.686AspArg: 3.686 ± 0.052	3.569AspSer: 3.569 ± 0.052	2.849AspThr: 2.849 ± 0.047	3.642AspVal: 3.642 ± 0.056	1.073AspTrp: 1.073 ± 0.036	2.249AspTyr: 2.249 ± 0.04	0.0AspXaa: 0.0 ± 0.0
Glu	6.673GluAla: 6.673 ± 0.079	0.461GluCys: 0.461 ± 0.018	3.398GluAsp: 3.398 ± 0.054	4.24GluGlu: 4.24 ± 0.078	2.205GluPhe: 2.205 ± 0.045	4.252GluGly: 4.252 ± 0.063	1.556GluHis: 1.556 ± 0.034	3.298GluIle: 3.298 ± 0.052	2.254GluLys: 2.254 ± 0.044	7.443GluLeu: 7.443 ± 0.09	1.481GluMet: 1.481 ± 0.035	1.856GluAsn: 1.856 ± 0.044	2.712GluPro: 2.712 ± 0.047	3.785GluGln: 3.785 ± 0.058	4.464GluArg: 4.464 ± 0.065	3.234GluSer: 3.234 ± 0.054	2.885GluThr: 2.885 ± 0.042	4.605GluVal: 4.605 ± 0.059	0.724GluTrp: 0.724 ± 0.026	1.699GluTyr: 1.699 ± 0.04	0.0GluXaa: 0.0 ± 0.0
Phe	3.683PheAla: 3.683 ± 0.054	0.479PheCys: 0.479 ± 0.021	2.601PheAsp: 2.601 ± 0.054	2.068PheGlu: 2.068 ± 0.042	1.426PhePhe: 1.426 ± 0.037	3.128PheGly: 3.128 ± 0.056	0.798PheHis: 0.798 ± 0.026	1.762PheIle: 1.762 ± 0.037	0.956PheLys: 0.956 ± 0.029	3.242PheLeu: 3.242 ± 0.054	0.887PheMet: 0.887 ± 0.024	1.371PheAsn: 1.371 ± 0.036	1.573PhePro: 1.573 ± 0.038	1.163PheGln: 1.163 ± 0.031	2.023PheArg: 2.023 ± 0.044	2.619PheSer: 2.619 ± 0.051	1.987PheThr: 1.987 ± 0.046	2.317PheVal: 2.317 ± 0.044	0.456PheTrp: 0.456 ± 0.019	1.153PheTyr: 1.153 ± 0.026	0.0PheXaa: 0.0 ± 0.0
Gly	7.817GlyAla: 7.817 ± 0.085	0.941GlyCys: 0.941 ± 0.029	4.915GlyAsp: 4.915 ± 0.074	5.608GlyGlu: 5.608 ± 0.077	3.252GlyPhe: 3.252 ± 0.054	6.595GlyGly: 6.595 ± 0.11	1.735GlyHis: 1.735 ± 0.036	4.493GlyIle: 4.493 ± 0.064	3.144GlyLys: 3.144 ± 0.057	8.4GlyLeu: 8.4 ± 0.085	2.435GlyMet: 2.435 ± 0.046	2.585GlyAsn: 2.585 ± 0.056	2.846GlyPro: 2.846 ± 0.043	3.196GlyGln: 3.196 ± 0.059	5.117GlyArg: 5.117 ± 0.066	4.966GlySer: 4.966 ± 0.077	3.821GlyThr: 3.821 ± 0.059	5.876GlyVal: 5.876 ± 0.08	1.248GlyTrp: 1.248 ± 0.034	2.572GlyTyr: 2.572 ± 0.046	0.0GlyXaa: 0.0 ± 0.0
His	1.887HisAla: 1.887 ± 0.034	0.353HisCys: 0.353 ± 0.017	1.017HisAsp: 1.017 ± 0.03	1.031HisGlu: 1.031 ± 0.03	0.845HisPhe: 0.845 ± 0.026	1.883HisGly: 1.883 ± 0.033	0.624HisHis: 0.624 ± 0.026	1.113HisIle: 1.113 ± 0.031	0.61HisLys: 0.61 ± 0.021	2.227HisLeu: 2.227 ± 0.042	0.514HisMet: 0.514 ± 0.021	0.672HisAsn: 0.672 ± 0.022	1.355HisPro: 1.355 ± 0.033	0.925HisGln: 0.925 ± 0.028	1.638HisArg: 1.638 ± 0.037	1.313HisSer: 1.313 ± 0.036	0.98HisThr: 0.98 ± 0.028	1.232HisVal: 1.232 ± 0.028	0.424HisTrp: 0.424 ± 0.018	0.845HisTyr: 0.845 ± 0.025	0.0HisXaa: 0.0 ± 0.0
Ile	6.003IleAla: 6.003 ± 0.076	0.528IleCys: 0.528 ± 0.021	3.645IleAsp: 3.645 ± 0.054	3.382IleGlu: 3.382 ± 0.058	1.61IlePhe: 1.61 ± 0.04	3.976IleGly: 3.976 ± 0.059	1.043IleHis: 1.043 ± 0.029	2.312IleIle: 2.312 ± 0.056	1.541IleLys: 1.541 ± 0.04	4.061IleLeu: 4.061 ± 0.062	0.99IleMet: 0.99 ± 0.027	1.94IleAsn: 1.94 ± 0.047	2.425IlePro: 2.425 ± 0.046	1.425IleGln: 1.425 ± 0.035	2.917IleArg: 2.917 ± 0.05	3.264IleSer: 3.264 ± 0.05	2.731IleThr: 2.731 ± 0.054	3.349IleVal: 3.349 ± 0.052	0.531IleTrp: 0.531 ± 0.02	1.361IleTyr: 1.361 ± 0.036	0.0IleXaa: 0.0 ± 0.0
Lys	3.234LysAla: 3.234 ± 0.056	0.213LysCys: 0.213 ± 0.018	1.42LysAsp: 1.42 ± 0.033	1.493LysGlu: 1.493 ± 0.038	0.884LysPhe: 0.884 ± 0.024	2.126LysGly: 2.126 ± 0.044	0.675LysHis: 0.675 ± 0.024	1.49LysIle: 1.49 ± 0.037	1.259LysLys: 1.259 ± 0.04	3.268LysLeu: 3.268 ± 0.052	0.689LysMet: 0.689 ± 0.026	0.919LysAsn: 0.919 ± 0.026	1.705LysPro: 1.705 ± 0.042	1.378LysGln: 1.378 ± 0.036	2.12LysArg: 2.12 ± 0.042	1.735LysSer: 1.735 ± 0.04	1.65LysThr: 1.65 ± 0.04	2.282LysVal: 2.282 ± 0.049	0.35LysTrp: 0.35 ± 0.017	0.768LysTyr: 0.768 ± 0.024	0.001LysXaa: 0.001 ± 0.001
Leu	13.919LeuAla: 13.919 ± 0.145	1.123LeuCys: 1.123 ± 0.034	6.731LeuAsp: 6.731 ± 0.079	6.833LeuGlu: 6.833 ± 0.083	3.684LeuPhe: 3.684 ± 0.052	8.53LeuGly: 8.53 ± 0.092	2.245LeuHis: 2.245 ± 0.039	4.303LeuIle: 4.303 ± 0.066	3.188LeuLys: 3.188 ± 0.055	12.019LeuLeu: 12.019 ± 0.149	2.287LeuMet: 2.287 ± 0.048	2.998LeuAsn: 2.998 ± 0.047	5.522LeuPro: 5.522 ± 0.074	4.825LeuGln: 4.825 ± 0.075	6.913LeuArg: 6.913 ± 0.092	6.272LeuSer: 6.272 ± 0.066	4.795LeuThr: 4.795 ± 0.07	7.867LeuVal: 7.867 ± 0.086	1.339LeuTrp: 1.339 ± 0.037	2.606LeuTyr: 2.606 ± 0.043	0.0LeuXaa: 0.0 ± 0.0
Met	2.853MetAla: 2.853 ± 0.048	0.186MetCys: 0.186 ± 0.012	1.367MetAsp: 1.367 ± 0.033	1.417MetGlu: 1.417 ± 0.038	0.72MetPhe: 0.72 ± 0.021	1.886MetGly: 1.886 ± 0.042	0.525MetHis: 0.525 ± 0.02	1.172MetIle: 1.172 ± 0.035	0.969MetLys: 0.969 ± 0.026	2.564MetLeu: 2.564 ± 0.041	0.576MetMet: 0.576 ± 0.021	0.824MetAsn: 0.824 ± 0.025	1.311MetPro: 1.311 ± 0.029	1.028MetGln: 1.028 ± 0.026	1.549MetArg: 1.549 ± 0.032	1.703MetSer: 1.703 ± 0.039	1.409MetThr: 1.409 ± 0.032	1.635MetVal: 1.635 ± 0.032	0.215MetTrp: 0.215 ± 0.012	0.46MetTyr: 0.46 ± 0.021	0.0MetXaa: 0.0 ± 0.0
Asn	3.025AsnAla: 3.025 ± 0.05	0.368AsnCys: 0.368 ± 0.016	1.582AsnAsp: 1.582 ± 0.044	1.561AsnGlu: 1.561 ± 0.038	1.133AsnPhe: 1.133 ± 0.03	2.324AsnGly: 2.324 ± 0.051	0.664AsnHis: 0.664 ± 0.022	1.677AsnIle: 1.677 ± 0.038	0.915AsnLys: 0.915 ± 0.027	2.981AsnLeu: 2.981 ± 0.05	0.724AsnMet: 0.724 ± 0.022	1.037AsnAsn: 1.037 ± 0.035	2.08AsnPro: 2.08 ± 0.05	1.071AsnGln: 1.071 ± 0.027	2.102AsnArg: 2.102 ± 0.04	1.821AsnSer: 1.821 ± 0.045	1.652AsnThr: 1.652 ± 0.035	1.945AsnVal: 1.945 ± 0.039	0.525AsnTrp: 0.525 ± 0.02	0.981AsnTyr: 0.981 ± 0.031	0.001AsnXaa: 0.001 ± 0.001
Pro	5.735ProAla: 5.735 ± 0.079	0.4ProCys: 0.4 ± 0.015	3.186ProAsp: 3.186 ± 0.048	3.799ProGlu: 3.799 ± 0.062	1.566ProPhe: 1.566 ± 0.035	4.823ProGly: 4.823 ± 0.066	0.944ProHis: 0.944 ± 0.03	1.804ProIle: 1.804 ± 0.041	1.059ProLys: 1.059 ± 0.035	5.127ProLeu: 5.127 ± 0.069	1.118ProMet: 1.118 ± 0.03	1.169ProAsn: 1.169 ± 0.031	2.195ProPro: 2.195 ± 0.052	1.873ProGln: 1.873 ± 0.036	2.874ProArg: 2.874 ± 0.049	2.177ProSer: 2.177 ± 0.048	1.923ProThr: 1.923 ± 0.041	4.067ProVal: 4.067 ± 0.063	0.735ProTrp: 0.735 ± 0.027	1.19ProTyr: 1.19 ± 0.028	0.001ProXaa: 0.001 ± 0.001
Gln	4.935GlnAla: 4.935 ± 0.084	0.365GlnCys: 0.365 ± 0.017	1.904GlnAsp: 1.904 ± 0.035	2.087GlnGlu: 2.087 ± 0.044	1.404GlnPhe: 1.404 ± 0.032	3.106GlnGly: 3.106 ± 0.05	0.929GlnHis: 0.929 ± 0.025	1.719GlnIle: 1.719 ± 0.036	1.06GlnLys: 1.06 ± 0.029	5.347GlnLeu: 5.347 ± 0.068	0.976GlnMet: 0.976 ± 0.028	0.839GlnAsn: 0.839 ± 0.026	2.001GlnPro: 2.001 ± 0.036	2.655GlnGln: 2.655 ± 0.053	3.454GlnArg: 3.454 ± 0.062	2.145GlnSer: 2.145 ± 0.043	1.646GlnThr: 1.646 ± 0.042	3.122GlnVal: 3.122 ± 0.054	0.715GlnTrp: 0.715 ± 0.025	1.032GlnTyr: 1.032 ± 0.028	0.0GlnXaa: 0.0 ± 0.0
Arg	6.381ArgAla: 6.381 ± 0.075	0.686ArgCys: 0.686 ± 0.026	4.027ArgAsp: 4.027 ± 0.06	5.079ArgGlu: 5.079 ± 0.064	2.684ArgPhe: 2.684 ± 0.045	4.599ArgGly: 4.599 ± 0.061	1.612ArgHis: 1.612 ± 0.039	3.376ArgIle: 3.376 ± 0.06	2.269ArgLys: 2.269 ± 0.048	7.378ArgLeu: 7.378 ± 0.081	1.634ArgMet: 1.634 ± 0.033	2.076ArgAsn: 2.076 ± 0.037	2.785ArgPro: 2.785 ± 0.049	3.403ArgGln: 3.403 ± 0.058	4.766ArgArg: 4.766 ± 0.084	3.659ArgSer: 3.659 ± 0.051	2.602ArgThr: 2.602 ± 0.046	4.6ArgVal: 4.6 ± 0.059	1.123ArgTrp: 1.123 ± 0.03	2.168ArgTyr: 2.168 ± 0.043	0.0ArgXaa: 0.0 ± 0.0
Ser	6.273SerAla: 6.273 ± 0.071	0.649SerCys: 0.649 ± 0.023	3.288SerAsp: 3.288 ± 0.062	3.518SerGlu: 3.518 ± 0.054	2.213SerPhe: 2.213 ± 0.041	5.656SerGly: 5.656 ± 0.069	1.279SerHis: 1.279 ± 0.03	2.864SerIle: 2.864 ± 0.051	1.64SerLys: 1.64 ± 0.038	6.568SerLeu: 6.568 ± 0.077	1.453SerMet: 1.453 ± 0.03	1.759SerAsn: 1.759 ± 0.042	2.838SerPro: 2.838 ± 0.049	2.12SerGln: 2.12 ± 0.041	4.041SerArg: 4.041 ± 0.057	3.529SerSer: 3.529 ± 0.061	2.769SerThr: 2.769 ± 0.05	3.951SerVal: 3.951 ± 0.057	0.856SerTrp: 0.856 ± 0.026	1.71SerTyr: 1.71 ± 0.037	0.0SerXaa: 0.0 ± 0.0
Thr	5.349ThrAla: 5.349 ± 0.063	0.462ThrCys: 0.462 ± 0.019	2.753ThrAsp: 2.753 ± 0.055	2.688ThrGlu: 2.688 ± 0.046	1.54ThrPhe: 1.54 ± 0.032	4.719ThrGly: 4.719 ± 0.065	0.925ThrHis: 0.925 ± 0.028	2.33ThrIle: 2.33 ± 0.047	0.821ThrLys: 0.821 ± 0.028	5.725ThrLeu: 5.725 ± 0.069	1.043ThrMet: 1.043 ± 0.034	1.179ThrAsn: 1.179 ± 0.032	2.773ThrPro: 2.773 ± 0.051	1.36ThrGln: 1.36 ± 0.034	3.242ThrArg: 3.242 ± 0.06	2.643ThrSer: 2.643 ± 0.051	2.51ThrThr: 2.51 ± 0.055	3.875ThrVal: 3.875 ± 0.062	0.646ThrTrp: 0.646 ± 0.026	1.278ThrTyr: 1.278 ± 0.036	0.0ThrXaa: 0.0 ± 0.0
Val	8.222ValAla: 8.222 ± 0.096	0.74ValCys: 0.74 ± 0.023	4.605ValAsp: 4.605 ± 0.054	4.497ValGlu: 4.497 ± 0.07	2.609ValPhe: 2.609 ± 0.045	4.915ValGly: 4.915 ± 0.058	1.381ValHis: 1.381 ± 0.031	3.985ValIle: 3.985 ± 0.06	2.111ValLys: 2.111 ± 0.045	7.315ValLeu: 7.315 ± 0.087	1.728ValMet: 1.728 ± 0.038	2.398ValAsn: 2.398 ± 0.044	3.364ValPro: 3.364 ± 0.058	2.238ValGln: 2.238 ± 0.04	4.005ValArg: 4.005 ± 0.06	4.568ValSer: 4.568 ± 0.063	3.951ValThr: 3.951 ± 0.057	5.504ValVal: 5.504 ± 0.07	0.809ValTrp: 0.809 ± 0.024	1.833ValTyr: 1.833 ± 0.04	0.0ValXaa: 0.0 ± 0.0
Trp	1.156TrpAla: 1.156 ± 0.036	0.167TrpCys: 0.167 ± 0.013	0.772TrpAsp: 0.772 ± 0.026	0.71TrpGlu: 0.71 ± 0.026	0.522TrpPhe: 0.522 ± 0.021	0.963TrpGly: 0.963 ± 0.028	0.331TrpHis: 0.331 ± 0.014	0.623TrpIle: 0.623 ± 0.022	0.38TrpLys: 0.38 ± 0.018	1.876TrpLeu: 1.876 ± 0.046	0.37TrpMet: 0.37 ± 0.016	0.428TrpAsn: 0.428 ± 0.017	0.631TrpPro: 0.631 ± 0.023	0.943TrpGln: 0.943 ± 0.031	1.094TrpArg: 1.094 ± 0.031	0.855TrpSer: 0.855 ± 0.026	0.646TrpThr: 0.646 ± 0.026	0.899TrpVal: 0.899 ± 0.027	0.224TrpTrp: 0.224 ± 0.014	0.413TrpTyr: 0.413 ± 0.018	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.568TyrAla: 2.568 ± 0.044	0.389TyrCys: 0.389 ± 0.02	1.625TyrAsp: 1.625 ± 0.043	1.468TyrGlu: 1.468 ± 0.039	1.121TyrPhe: 1.121 ± 0.033	2.266TyrGly: 2.266 ± 0.046	0.702TyrHis: 0.702 ± 0.022	1.213TyrIle: 1.213 ± 0.034	0.715TyrLys: 0.715 ± 0.024	3.236TyrLeu: 3.236 ± 0.05	0.579TyrMet: 0.579 ± 0.024	0.872TyrAsn: 0.872 ± 0.03	1.385TyrPro: 1.385 ± 0.036	1.394TyrGln: 1.394 ± 0.036	2.459TyrArg: 2.459 ± 0.045	1.768TyrSer: 1.768 ± 0.034	1.405TyrThr: 1.405 ± 0.033	1.665TyrVal: 1.665 ± 0.042	0.436TyrTrp: 0.436 ± 0.018	0.948TyrTyr: 0.948 ± 0.03	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.002XaaCys: 0.002 ± 0.001	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.001XaaVal: 0.001 ± 0.001	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3770 proteins (1298764 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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