Amino acid dipepetide frequency for Penaeus vannamei (Whiteleg shrimp) (Litopenaeus vannamei)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	6.231AlaAla: 6.231 ± 0.054	1.233AlaCys: 1.233 ± 0.02	2.702AlaAsp: 2.702 ± 0.026	3.688AlaGlu: 3.688 ± 0.055	2.363AlaPhe: 2.363 ± 0.03	4.147AlaGly: 4.147 ± 0.045	1.791AlaHis: 1.791 ± 0.023	2.378AlaIle: 2.378 ± 0.025	2.763AlaLys: 2.763 ± 0.038	6.375AlaLeu: 6.375 ± 0.049	1.225AlaMet: 1.225 ± 0.015	1.925AlaAsn: 1.925 ± 0.022	5.247AlaPro: 5.247 ± 0.061	2.332AlaGln: 2.332 ± 0.028	4.302AlaArg: 4.302 ± 0.05	6.892AlaSer: 6.892 ± 0.059	4.043AlaThr: 4.043 ± 0.042	4.272AlaVal: 4.272 ± 0.037	0.731AlaTrp: 0.731 ± 0.012	1.281AlaTyr: 1.281 ± 0.016	0.0AlaXaa: 0.0 ± 0.0
Cys	1.078CysAla: 1.078 ± 0.02	0.524CysCys: 0.524 ± 0.014	0.843CysAsp: 0.843 ± 0.014	0.863CysGlu: 0.863 ± 0.014	0.831CysPhe: 0.831 ± 0.018	1.231CysGly: 1.231 ± 0.019	0.748CysHis: 0.748 ± 0.022	0.708CysIle: 0.708 ± 0.014	0.672CysLys: 0.672 ± 0.011	2.181CysLeu: 2.181 ± 0.036	0.305CysMet: 0.305 ± 0.007	0.599CysAsn: 0.599 ± 0.011	1.75CysPro: 1.75 ± 0.028	0.815CysGln: 0.815 ± 0.017	1.267CysArg: 1.267 ± 0.019	1.934CysSer: 1.934 ± 0.032	0.952CysThr: 0.952 ± 0.018	1.145CysVal: 1.145 ± 0.018	0.226CysTrp: 0.226 ± 0.009	0.48CysTyr: 0.48 ± 0.014	0.0CysXaa: 0.0 ± 0.0
Asp	2.901AspAla: 2.901 ± 0.028	0.761AspCys: 0.761 ± 0.016	2.579AspAsp: 2.579 ± 0.03	2.811AspGlu: 2.811 ± 0.027	1.624AspPhe: 1.624 ± 0.019	2.881AspGly: 2.881 ± 0.036	1.077AspHis: 1.077 ± 0.016	1.971AspIle: 1.971 ± 0.02	1.754AspLys: 1.754 ± 0.02	3.96AspLeu: 3.96 ± 0.038	0.861AspMet: 0.861 ± 0.012	1.426AspAsn: 1.426 ± 0.019	2.532AspPro: 2.532 ± 0.035	1.417AspGln: 1.417 ± 0.018	2.188AspArg: 2.188 ± 0.027	3.508AspSer: 3.508 ± 0.042	2.329AspThr: 2.329 ± 0.028	2.72AspVal: 2.72 ± 0.026	0.478AspTrp: 0.478 ± 0.011	1.154AspTyr: 1.154 ± 0.015	0.0AspXaa: 0.0 ± 0.0
Glu	4.456GluAla: 4.456 ± 0.067	0.95GluCys: 0.95 ± 0.017	3.277GluAsp: 3.277 ± 0.032	5.441GluGlu: 5.441 ± 0.077	1.355GluPhe: 1.355 ± 0.013	3.758GluGly: 3.758 ± 0.04	1.048GluHis: 1.048 ± 0.012	2.084GluIle: 2.084 ± 0.025	3.026GluLys: 3.026 ± 0.035	3.731GluLeu: 3.731 ± 0.034	1.241GluMet: 1.241 ± 0.029	1.995GluAsn: 1.995 ± 0.018	2.593GluPro: 2.593 ± 0.044	1.825GluGln: 1.825 ± 0.023	3.348GluArg: 3.348 ± 0.042	3.653GluSer: 3.653 ± 0.037	2.82GluThr: 2.82 ± 0.042	3.488GluVal: 3.488 ± 0.033	0.561GluTrp: 0.561 ± 0.011	1.18GluTyr: 1.18 ± 0.018	0.0GluXaa: 0.0 ± 0.0
Phe	2.001PheAla: 2.001 ± 0.023	0.841PheCys: 0.841 ± 0.018	1.347PheAsp: 1.347 ± 0.018	1.411PheGlu: 1.411 ± 0.022	2.787PhePhe: 2.787 ± 0.045	1.946PheGly: 1.946 ± 0.029	1.379PheHis: 1.379 ± 0.027	1.721PheIle: 1.721 ± 0.025	1.17PheLys: 1.17 ± 0.013	6.468PheLeu: 6.468 ± 0.073	0.622PheMet: 0.622 ± 0.011	1.122PheAsn: 1.122 ± 0.017	5.529PhePro: 5.529 ± 0.067	1.213PheGln: 1.213 ± 0.02	2.028PheArg: 2.028 ± 0.029	5.754PheSer: 5.754 ± 0.062	2.303PheThr: 2.303 ± 0.027	2.017PheVal: 2.017 ± 0.028	0.384PheTrp: 0.384 ± 0.011	1.112PheTyr: 1.112 ± 0.019	0.001PheXaa: 0.001 ± 0.0
Gly	4.023GlyAla: 4.023 ± 0.042	1.038GlyCys: 1.038 ± 0.018	2.765GlyAsp: 2.765 ± 0.029	3.326GlyGlu: 3.326 ± 0.034	2.049GlyPhe: 2.049 ± 0.043	5.629GlyGly: 5.629 ± 0.075	1.56GlyHis: 1.56 ± 0.022	2.183GlyIle: 2.183 ± 0.027	2.539GlyLys: 2.539 ± 0.031	4.509GlyLeu: 4.509 ± 0.047	1.086GlyMet: 1.086 ± 0.013	1.904GlyAsn: 1.904 ± 0.025	3.09GlyPro: 3.09 ± 0.051	2.077GlyGln: 2.077 ± 0.029	4.509GlyArg: 4.509 ± 0.052	5.327GlySer: 5.327 ± 0.068	3.146GlyThr: 3.146 ± 0.039	3.632GlyVal: 3.632 ± 0.039	0.681GlyTrp: 0.681 ± 0.012	1.496GlyTyr: 1.496 ± 0.021	0.0GlyXaa: 0.0 ± 0.0
His	1.782HisAla: 1.782 ± 0.024	0.586HisCys: 0.586 ± 0.017	1.009HisAsp: 1.009 ± 0.016	1.111HisGlu: 1.111 ± 0.018	1.42HisPhe: 1.42 ± 0.031	1.452HisGly: 1.452 ± 0.026	1.739HisHis: 1.739 ± 0.037	1.24HisIle: 1.24 ± 0.026	0.99HisLys: 0.99 ± 0.017	3.688HisLeu: 3.688 ± 0.048	0.49HisMet: 0.49 ± 0.008	0.97HisAsn: 0.97 ± 0.019	4.024HisPro: 4.024 ± 0.061	1.35HisGln: 1.35 ± 0.03	1.809HisArg: 1.809 ± 0.027	3.598HisSer: 3.598 ± 0.073	2.234HisThr: 2.234 ± 0.052	1.471HisVal: 1.471 ± 0.021	0.27HisTrp: 0.27 ± 0.007	0.78HisTyr: 0.78 ± 0.014	0.0HisXaa: 0.0 ± 0.0
Ile	2.272IleAla: 2.272 ± 0.024	0.723IleCys: 0.723 ± 0.014	1.571IleAsp: 1.571 ± 0.016	1.766IleGlu: 1.766 ± 0.019	1.624IlePhe: 1.624 ± 0.021	1.761IleGly: 1.761 ± 0.021	1.354IleHis: 1.354 ± 0.029	1.804IleIle: 1.804 ± 0.025	1.629IleLys: 1.629 ± 0.017	4.028IleLeu: 4.028 ± 0.039	0.725IleMet: 0.725 ± 0.01	1.413IleAsn: 1.413 ± 0.018	3.461IlePro: 3.461 ± 0.044	1.427IleGln: 1.427 ± 0.022	2.046IleArg: 2.046 ± 0.026	3.792IleSer: 3.792 ± 0.042	2.487IleThr: 2.487 ± 0.028	2.052IleVal: 2.052 ± 0.02	0.38IleTrp: 0.38 ± 0.011	1.048IleTyr: 1.048 ± 0.021	0.0IleXaa: 0.0 ± 0.0
Lys	2.798LysAla: 2.798 ± 0.034	0.725LysCys: 0.725 ± 0.013	2.21LysAsp: 2.21 ± 0.024	3.216LysGlu: 3.216 ± 0.042	1.182LysPhe: 1.182 ± 0.018	2.329LysGly: 2.329 ± 0.03	0.968LysHis: 0.968 ± 0.021	1.725LysIle: 1.725 ± 0.02	2.945LysLys: 2.945 ± 0.038	3.062LysLeu: 3.062 ± 0.025	0.929LysMet: 0.929 ± 0.009	1.523LysAsn: 1.523 ± 0.019	2.442LysPro: 2.442 ± 0.038	1.588LysGln: 1.588 ± 0.032	2.539LysArg: 2.539 ± 0.033	2.79LysSer: 2.79 ± 0.034	2.376LysThr: 2.376 ± 0.03	2.418LysVal: 2.418 ± 0.023	0.432LysTrp: 0.432 ± 0.008	1.098LysTyr: 1.098 ± 0.016	0.0LysXaa: 0.0 ± 0.0
Leu	6.639LeuAla: 6.639 ± 0.052	2.039LeuCys: 2.039 ± 0.028	3.517LeuAsp: 3.517 ± 0.031	4.432LeuGlu: 4.432 ± 0.044	5.571LeuPhe: 5.571 ± 0.072	4.663LeuGly: 4.663 ± 0.05	3.689LeuHis: 3.689 ± 0.044	3.47LeuIle: 3.47 ± 0.035	3.429LeuLys: 3.429 ± 0.032	14.253LeuLeu: 14.253 ± 0.123	1.552LeuMet: 1.552 ± 0.017	2.638LeuAsn: 2.638 ± 0.027	14.085LeuPro: 14.085 ± 0.123	3.91LeuGln: 3.91 ± 0.037	5.776LeuArg: 5.776 ± 0.043	13.883LeuSer: 13.883 ± 0.127	5.735LeuThr: 5.735 ± 0.051	5.222LeuVal: 5.222 ± 0.048	0.951LeuTrp: 0.951 ± 0.018	2.355LeuTyr: 2.355 ± 0.023	0.002LeuXaa: 0.002 ± 0.0
Met	1.459MetAla: 1.459 ± 0.015	0.35MetCys: 0.35 ± 0.007	0.872MetAsp: 0.872 ± 0.011	1.285MetGlu: 1.285 ± 0.025	0.586MetPhe: 0.586 ± 0.011	1.051MetGly: 1.051 ± 0.013	0.368MetHis: 0.368 ± 0.007	0.631MetIle: 0.631 ± 0.008	0.937MetLys: 0.937 ± 0.011	1.429MetLeu: 1.429 ± 0.018	0.458MetMet: 0.458 ± 0.007	0.634MetAsn: 0.634 ± 0.008	0.983MetPro: 0.983 ± 0.015	0.651MetGln: 0.651 ± 0.01	0.958MetArg: 0.958 ± 0.012	1.389MetSer: 1.389 ± 0.016	1.036MetThr: 1.036 ± 0.012	1.118MetVal: 1.118 ± 0.014	0.206MetTrp: 0.206 ± 0.006	0.451MetTyr: 0.451 ± 0.008	0.0MetXaa: 0.0 ± 0.0
Asn	1.884AsnAla: 1.884 ± 0.019	0.573AsnCys: 0.573 ± 0.01	1.321AsnAsp: 1.321 ± 0.017	1.551AsnGlu: 1.551 ± 0.015	1.163AsnPhe: 1.163 ± 0.012	1.892AsnGly: 1.892 ± 0.025	0.973AsnHis: 0.973 ± 0.028	1.57AsnIle: 1.57 ± 0.02	1.558AsnLys: 1.558 ± 0.032	2.963AsnLeu: 2.963 ± 0.027	0.676AsnMet: 0.676 ± 0.009	1.421AsnAsn: 1.421 ± 0.022	2.502AsnPro: 2.502 ± 0.035	1.293AsnGln: 1.293 ± 0.028	1.745AsnArg: 1.745 ± 0.032	2.559AsnSer: 2.559 ± 0.029	1.97AsnThr: 1.97 ± 0.027	1.755AsnVal: 1.755 ± 0.017	0.307AsnTrp: 0.307 ± 0.006	0.881AsnTyr: 0.881 ± 0.014	0.0AsnXaa: 0.0 ± 0.0
Pro	5.466ProAla: 5.466 ± 0.061	1.626ProCys: 1.626 ± 0.035	2.563ProAsp: 2.563 ± 0.028	3.417ProGlu: 3.417 ± 0.048	5.528ProPhe: 5.528 ± 0.067	3.927ProGly: 3.927 ± 0.058	3.892ProHis: 3.892 ± 0.062	2.927ProIle: 2.927 ± 0.038	2.48ProLys: 2.48 ± 0.04	12.755ProLeu: 12.755 ± 0.128	0.898ProMet: 0.898 ± 0.012	2.091ProAsn: 2.091 ± 0.03	16.838ProPro: 16.838 ± 0.184	3.25ProGln: 3.25 ± 0.05	5.783ProArg: 5.783 ± 0.085	15.055ProSer: 15.055 ± 0.134	5.892ProThr: 5.892 ± 0.081	3.98ProVal: 3.98 ± 0.043	0.736ProTrp: 0.736 ± 0.023	1.975ProTyr: 1.975 ± 0.03	0.001ProXaa: 0.001 ± 0.0
Gln	2.575GlnAla: 2.575 ± 0.032	0.701GlnCys: 0.701 ± 0.016	1.707GlnAsp: 1.707 ± 0.023	2.618GlnGlu: 2.618 ± 0.031	1.008GlnPhe: 1.008 ± 0.015	2.307GlnGly: 2.307 ± 0.037	1.24GlnHis: 1.24 ± 0.024	1.273GlnIle: 1.273 ± 0.018	1.749GlnLys: 1.749 ± 0.025	3.238GlnLeu: 3.238 ± 0.035	0.728GlnMet: 0.728 ± 0.012	1.268GlnAsn: 1.268 ± 0.02	3.036GlnPro: 3.036 ± 0.053	2.319GlnGln: 2.319 ± 0.044	2.552GlnArg: 2.552 ± 0.039	2.811GlnSer: 2.811 ± 0.042	2.264GlnThr: 2.264 ± 0.041	2.321GlnVal: 2.321 ± 0.031	0.382GlnTrp: 0.382 ± 0.008	0.925GlnTyr: 0.925 ± 0.013	0.0GlnXaa: 0.0 ± 0.0
Arg	4.069ArgAla: 4.069 ± 0.045	1.247ArgCys: 1.247 ± 0.018	2.765ArgAsp: 2.765 ± 0.037	3.494ArgGlu: 3.494 ± 0.039	2.064ArgPhe: 2.064 ± 0.032	4.233ArgGly: 4.233 ± 0.053	2.009ArgHis: 2.009 ± 0.036	2.121ArgIle: 2.121 ± 0.028	2.838ArgLys: 2.838 ± 0.029	5.523ArgLeu: 5.523 ± 0.05	1.037ArgMet: 1.037 ± 0.015	1.928ArgAsn: 1.928 ± 0.023	5.546ArgPro: 5.546 ± 0.073	2.542ArgGln: 2.542 ± 0.036	6.245ArgArg: 6.245 ± 0.079	5.346ArgSer: 5.346 ± 0.057	3.413ArgThr: 3.413 ± 0.038	3.285ArgVal: 3.285 ± 0.032	0.863ArgTrp: 0.863 ± 0.03	1.317ArgTyr: 1.317 ± 0.015	0.001ArgXaa: 0.001 ± 0.0
Ser	6.118SerAla: 6.118 ± 0.057	1.983SerCys: 1.983 ± 0.029	3.431SerAsp: 3.431 ± 0.036	3.854SerGlu: 3.854 ± 0.041	6.016SerPhe: 6.016 ± 0.071	5.235SerGly: 5.235 ± 0.063	3.496SerHis: 3.496 ± 0.057	3.517SerIle: 3.517 ± 0.037	2.835SerLys: 2.835 ± 0.029	14.941SerLeu: 14.941 ± 0.138	1.277SerMet: 1.277 ± 0.015	2.57SerAsn: 2.57 ± 0.036	14.22SerPro: 14.22 ± 0.136	3.406SerGln: 3.406 ± 0.041	5.945SerArg: 5.945 ± 0.063	16.277SerSer: 16.277 ± 0.179	6.15SerThr: 6.15 ± 0.075	4.973SerVal: 4.973 ± 0.047	0.985SerTrp: 0.985 ± 0.019	2.186SerTyr: 2.186 ± 0.029	0.001SerXaa: 0.001 ± 0.0
Thr	4.027ThrAla: 4.027 ± 0.045	1.253ThrCys: 1.253 ± 0.021	2.27ThrAsp: 2.27 ± 0.03	2.756ThrGlu: 2.756 ± 0.039	2.241ThrPhe: 2.241 ± 0.028	2.974ThrGly: 2.974 ± 0.033	2.16ThrHis: 2.16 ± 0.044	2.232ThrIle: 2.232 ± 0.031	2.167ThrLys: 2.167 ± 0.029	5.864ThrLeu: 5.864 ± 0.059	0.879ThrMet: 0.879 ± 0.013	1.937ThrAsn: 1.937 ± 0.04	6.662ThrPro: 6.662 ± 0.085	2.289ThrGln: 2.289 ± 0.038	3.392ThrArg: 3.392 ± 0.044	6.463ThrSer: 6.463 ± 0.073	5.295ThrThr: 5.295 ± 0.137	3.231ThrVal: 3.231 ± 0.031	0.678ThrTrp: 0.678 ± 0.013	1.392ThrTyr: 1.392 ± 0.025	0.0ThrXaa: 0.0 ± 0.0
Val	4.164ValAla: 4.164 ± 0.036	1.264ValCys: 1.264 ± 0.019	2.567ValAsp: 2.567 ± 0.023	3.103ValGlu: 3.103 ± 0.041	2.271ValPhe: 2.271 ± 0.028	3.153ValGly: 3.153 ± 0.031	1.395ValHis: 1.395 ± 0.021	2.305ValIle: 2.305 ± 0.024	2.397ValLys: 2.397 ± 0.027	5.301ValLeu: 5.301 ± 0.047	1.14ValMet: 1.14 ± 0.014	1.823ValAsn: 1.823 ± 0.019	3.916ValPro: 3.916 ± 0.043	1.996ValGln: 1.996 ± 0.028	3.157ValArg: 3.157 ± 0.031	5.335ValSer: 5.335 ± 0.048	3.717ValThr: 3.717 ± 0.035	3.893ValVal: 3.893 ± 0.043	0.677ValTrp: 0.677 ± 0.012	1.418ValTyr: 1.418 ± 0.017	0.0ValXaa: 0.0 ± 0.0
Trp	0.719TrpAla: 0.719 ± 0.014	0.249TrpCys: 0.249 ± 0.008	0.507TrpAsp: 0.507 ± 0.012	0.53TrpGlu: 0.53 ± 0.008	0.355TrpPhe: 0.355 ± 0.007	0.668TrpGly: 0.668 ± 0.017	0.317TrpHis: 0.317 ± 0.011	0.438TrpIle: 0.438 ± 0.01	0.481TrpLys: 0.481 ± 0.011	1.0TrpLeu: 1.0 ± 0.019	0.244TrpMet: 0.244 ± 0.006	0.406TrpAsn: 0.406 ± 0.01	0.549TrpPro: 0.549 ± 0.013	0.413TrpGln: 0.413 ± 0.01	0.943TrpArg: 0.943 ± 0.023	0.847TrpSer: 0.847 ± 0.02	0.597TrpThr: 0.597 ± 0.012	0.653TrpVal: 0.653 ± 0.014	0.198TrpTrp: 0.198 ± 0.006	0.28TrpTyr: 0.28 ± 0.007	0.0TrpXaa: 0.0 ± 0.0
Tyr	1.261TyrAla: 1.261 ± 0.015	0.485TyrCys: 0.485 ± 0.01	1.111TyrAsp: 1.111 ± 0.014	1.158TyrGlu: 1.158 ± 0.015	1.118TyrPhe: 1.118 ± 0.024	1.331TyrGly: 1.331 ± 0.018	0.808TyrHis: 0.808 ± 0.017	1.063TyrIle: 1.063 ± 0.02	0.936TyrLys: 0.936 ± 0.015	2.539TyrLeu: 2.539 ± 0.03	0.478TyrMet: 0.478 ± 0.008	0.961TyrAsn: 0.961 ± 0.022	2.073TyrPro: 2.073 ± 0.032	0.91TyrGln: 0.91 ± 0.017	1.353TyrArg: 1.353 ± 0.02	2.201TyrSer: 2.201 ± 0.026	1.403TyrThr: 1.403 ± 0.021	1.347TyrVal: 1.347 ± 0.014	0.269TyrTrp: 0.269 ± 0.006	0.762TyrTyr: 0.762 ± 0.015	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.001XaaLeu: 0.001 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.001XaaPro: 0.001 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.001XaaArg: 0.001 ± 0.0	0.001XaaSer: 0.001 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.028XaaXaa: 0.028 ± 0.009

Statistics based on 25399 proteins (13085305 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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