Amino acid dipepetide frequency for Synechococcus phage S-SBP1

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
11.074AlaAla: 11.074 ± 1.003
0.923AlaCys: 0.923 ± 0.389
6.247AlaAsp: 6.247 ± 0.659
7.241AlaGlu: 7.241 ± 1.077
3.833AlaPhe: 3.833 ± 0.438
6.815AlaGly: 6.815 ± 0.973
0.852AlaHis: 0.852 ± 0.228
4.969AlaIle: 4.969 ± 0.535
3.336AlaLys: 3.336 ± 0.736
6.247AlaLeu: 6.247 ± 0.744
2.272AlaMet: 2.272 ± 0.388
3.407AlaAsn: 3.407 ± 0.383
3.904AlaPro: 3.904 ± 0.496
4.827AlaGln: 4.827 ± 0.596
3.833AlaArg: 3.833 ± 0.596
6.247AlaSer: 6.247 ± 0.606
5.253AlaThr: 5.253 ± 0.648
5.395AlaVal: 5.395 ± 0.622
0.852AlaTrp: 0.852 ± 0.269
2.556AlaTyr: 2.556 ± 0.431
0.0AlaXaa: 0.0 ± 0.0
Cys
0.639CysAla: 0.639 ± 0.256
0.071CysCys: 0.071 ± 0.065
0.568CysAsp: 0.568 ± 0.18
0.71CysGlu: 0.71 ± 0.243
0.284CysPhe: 0.284 ± 0.144
0.355CysGly: 0.355 ± 0.174
0.213CysHis: 0.213 ± 0.136
0.426CysIle: 0.426 ± 0.202
0.781CysLys: 0.781 ± 0.297
0.568CysLeu: 0.568 ± 0.209
0.426CysMet: 0.426 ± 0.205
0.426CysAsn: 0.426 ± 0.178
0.071CysPro: 0.071 ± 0.07
0.284CysGln: 0.284 ± 0.134
0.284CysArg: 0.284 ± 0.165
0.923CysSer: 0.923 ± 0.312
0.781CysThr: 0.781 ± 0.238
0.497CysVal: 0.497 ± 0.189
0.071CysTrp: 0.071 ± 0.075
0.142CysTyr: 0.142 ± 0.111
0.0CysXaa: 0.0 ± 0.0
Asp
6.247AspAla: 6.247 ± 0.627
0.355AspCys: 0.355 ± 0.18
4.614AspAsp: 4.614 ± 0.603
5.04AspGlu: 5.04 ± 0.744
1.988AspPhe: 1.988 ± 0.309
5.111AspGly: 5.111 ± 0.717
0.852AspHis: 0.852 ± 0.252
3.904AspIle: 3.904 ± 0.615
3.691AspLys: 3.691 ± 0.533
5.395AspLeu: 5.395 ± 0.656
1.491AspMet: 1.491 ± 0.275
3.194AspAsn: 3.194 ± 0.781
3.62AspPro: 3.62 ± 0.625
2.272AspGln: 2.272 ± 0.465
2.91AspArg: 2.91 ± 0.333
3.62AspSer: 3.62 ± 0.774
4.472AspThr: 4.472 ± 0.701
4.33AspVal: 4.33 ± 0.576
1.349AspTrp: 1.349 ± 0.372
2.627AspTyr: 2.627 ± 0.465
0.0AspXaa: 0.0 ± 0.0
Glu
6.034GluAla: 6.034 ± 0.921
0.71GluCys: 0.71 ± 0.27
2.627GluAsp: 2.627 ± 0.397
4.046GluGlu: 4.046 ± 0.704
3.052GluPhe: 3.052 ± 0.377
3.407GluGly: 3.407 ± 0.578
0.71GluHis: 0.71 ± 0.231
3.549GluIle: 3.549 ± 0.416
2.839GluLys: 2.839 ± 0.569
6.886GluLeu: 6.886 ± 0.768
1.846GluMet: 1.846 ± 0.374
2.414GluAsn: 2.414 ± 0.39
1.491GluPro: 1.491 ± 0.406
3.265GluGln: 3.265 ± 0.563
2.839GluArg: 2.839 ± 0.522
2.698GluSer: 2.698 ± 0.536
3.691GluThr: 3.691 ± 0.701
4.401GluVal: 4.401 ± 0.614
1.207GluTrp: 1.207 ± 0.335
2.13GluTyr: 2.13 ± 0.357
0.0GluXaa: 0.0 ± 0.0
Phe
2.059PheAla: 2.059 ± 0.368
0.355PheCys: 0.355 ± 0.17
3.407PheAsp: 3.407 ± 0.474
1.491PheGlu: 1.491 ± 0.361
1.775PhePhe: 1.775 ± 0.356
2.627PheGly: 2.627 ± 0.39
0.923PheHis: 0.923 ± 0.273
2.91PheIle: 2.91 ± 0.414
2.414PheLys: 2.414 ± 0.368
2.272PheLeu: 2.272 ± 0.432
1.42PheMet: 1.42 ± 0.323
2.059PheAsn: 2.059 ± 0.492
1.065PhePro: 1.065 ± 0.337
1.562PheGln: 1.562 ± 0.386
1.775PheArg: 1.775 ± 0.35
2.485PheSer: 2.485 ± 0.494
2.769PheThr: 2.769 ± 0.484
2.13PheVal: 2.13 ± 0.423
0.213PheTrp: 0.213 ± 0.131
1.065PheTyr: 1.065 ± 0.254
0.0PheXaa: 0.0 ± 0.0
Gly
5.182GlyAla: 5.182 ± 0.501
0.426GlyCys: 0.426 ± 0.168
4.827GlyAsp: 4.827 ± 0.882
3.904GlyGlu: 3.904 ± 0.638
2.556GlyPhe: 2.556 ± 0.414
6.318GlyGly: 6.318 ± 2.011
1.136GlyHis: 1.136 ± 0.267
3.691GlyIle: 3.691 ± 0.503
4.614GlyLys: 4.614 ± 0.539
5.466GlyLeu: 5.466 ± 0.55
2.414GlyMet: 2.414 ± 0.341
4.188GlyAsn: 4.188 ± 0.583
2.343GlyPro: 2.343 ± 0.334
3.123GlyGln: 3.123 ± 0.5
3.478GlyArg: 3.478 ± 0.539
5.182GlySer: 5.182 ± 1.076
5.963GlyThr: 5.963 ± 0.923
5.111GlyVal: 5.111 ± 0.525
1.065GlyTrp: 1.065 ± 0.281
3.336GlyTyr: 3.336 ± 0.42
0.0GlyXaa: 0.0 ± 0.0
His
0.639HisAla: 0.639 ± 0.248
0.213HisCys: 0.213 ± 0.12
1.065HisAsp: 1.065 ± 0.336
1.065HisGlu: 1.065 ± 0.292
0.497HisPhe: 0.497 ± 0.237
1.349HisGly: 1.349 ± 0.31
0.426HisHis: 0.426 ± 0.218
0.781HisIle: 0.781 ± 0.208
0.923HisLys: 0.923 ± 0.266
1.562HisLeu: 1.562 ± 0.414
0.923HisMet: 0.923 ± 0.243
1.136HisAsn: 1.136 ± 0.318
0.994HisPro: 0.994 ± 0.225
0.639HisGln: 0.639 ± 0.212
1.065HisArg: 1.065 ± 0.249
0.71HisSer: 0.71 ± 0.198
1.349HisThr: 1.349 ± 0.302
0.852HisVal: 0.852 ± 0.251
0.213HisTrp: 0.213 ± 0.138
0.71HisTyr: 0.71 ± 0.218
0.0HisXaa: 0.0 ± 0.0
Ile
5.182IleAla: 5.182 ± 0.553
0.284IleCys: 0.284 ± 0.125
4.046IleAsp: 4.046 ± 0.731
2.769IleGlu: 2.769 ± 0.555
1.633IlePhe: 1.633 ± 0.314
3.904IleGly: 3.904 ± 0.509
0.923IleHis: 0.923 ± 0.305
2.556IleIle: 2.556 ± 0.39
3.62IleLys: 3.62 ± 0.651
3.478IleLeu: 3.478 ± 0.414
1.207IleMet: 1.207 ± 0.318
3.265IleAsn: 3.265 ± 0.438
2.343IlePro: 2.343 ± 0.421
3.407IleGln: 3.407 ± 0.531
2.698IleArg: 2.698 ± 0.5
4.614IleSer: 4.614 ± 0.575
4.543IleThr: 4.543 ± 1.295
2.698IleVal: 2.698 ± 0.362
0.426IleTrp: 0.426 ± 0.171
1.491IleTyr: 1.491 ± 0.341
0.0IleXaa: 0.0 ± 0.0
Lys
4.756LysAla: 4.756 ± 0.797
0.213LysCys: 0.213 ± 0.129
3.336LysAsp: 3.336 ± 0.529
3.265LysGlu: 3.265 ± 0.472
1.562LysPhe: 1.562 ± 0.309
2.414LysGly: 2.414 ± 0.431
1.065LysHis: 1.065 ± 0.309
3.123LysIle: 3.123 ± 0.432
3.052LysLys: 3.052 ± 0.56
5.537LysLeu: 5.537 ± 0.722
1.278LysMet: 1.278 ± 0.347
2.698LysAsn: 2.698 ± 0.373
2.627LysPro: 2.627 ± 0.568
1.846LysGln: 1.846 ± 0.36
2.839LysArg: 2.839 ± 0.443
3.194LysSer: 3.194 ± 0.336
5.04LysThr: 5.04 ± 0.58
3.265LysVal: 3.265 ± 0.715
0.426LysTrp: 0.426 ± 0.174
2.485LysTyr: 2.485 ± 0.483
0.0LysXaa: 0.0 ± 0.0
Leu
6.46LeuAla: 6.46 ± 0.794
0.852LeuCys: 0.852 ± 0.299
4.756LeuAsp: 4.756 ± 0.462
4.614LeuGlu: 4.614 ± 0.574
2.343LeuPhe: 2.343 ± 0.451
5.679LeuGly: 5.679 ± 0.611
2.059LeuHis: 2.059 ± 0.375
3.62LeuIle: 3.62 ± 0.576
5.253LeuLys: 5.253 ± 0.754
5.892LeuLeu: 5.892 ± 0.772
2.059LeuMet: 2.059 ± 0.458
4.117LeuAsn: 4.117 ± 0.522
3.336LeuPro: 3.336 ± 0.463
4.259LeuGln: 4.259 ± 0.727
4.898LeuArg: 4.898 ± 0.553
5.182LeuSer: 5.182 ± 0.512
5.111LeuThr: 5.111 ± 0.534
4.543LeuVal: 4.543 ± 0.619
0.213LeuTrp: 0.213 ± 0.165
2.414LeuTyr: 2.414 ± 0.419
0.0LeuXaa: 0.0 ± 0.0
Met
2.839MetAla: 2.839 ± 0.442
0.213MetCys: 0.213 ± 0.116
2.059MetAsp: 2.059 ± 0.426
1.562MetGlu: 1.562 ± 0.314
1.42MetPhe: 1.42 ± 0.334
1.846MetGly: 1.846 ± 0.42
0.568MetHis: 0.568 ± 0.276
1.207MetIle: 1.207 ± 0.277
1.775MetLys: 1.775 ± 0.423
1.704MetLeu: 1.704 ± 0.301
0.355MetMet: 0.355 ± 0.165
1.136MetAsn: 1.136 ± 0.287
1.136MetPro: 1.136 ± 0.237
1.136MetGln: 1.136 ± 0.266
1.775MetArg: 1.775 ± 0.398
1.846MetSer: 1.846 ± 0.355
1.775MetThr: 1.775 ± 0.36
1.349MetVal: 1.349 ± 0.272
0.142MetTrp: 0.142 ± 0.104
0.71MetTyr: 0.71 ± 0.274
0.0MetXaa: 0.0 ± 0.0
Asn
5.537AsnAla: 5.537 ± 0.855
0.284AsnCys: 0.284 ± 0.171
3.407AsnAsp: 3.407 ± 0.705
2.414AsnGlu: 2.414 ± 0.393
2.201AsnPhe: 2.201 ± 0.372
4.33AsnGly: 4.33 ± 0.714
0.71AsnHis: 0.71 ± 0.216
2.059AsnIle: 2.059 ± 0.39
1.846AsnLys: 1.846 ± 0.304
3.691AsnLeu: 3.691 ± 0.458
1.207AsnMet: 1.207 ± 0.258
2.839AsnAsn: 2.839 ± 0.467
2.981AsnPro: 2.981 ± 0.385
1.562AsnGln: 1.562 ± 0.376
2.839AsnArg: 2.839 ± 0.423
4.188AsnSer: 4.188 ± 0.837
2.91AsnThr: 2.91 ± 0.482
3.407AsnVal: 3.407 ± 0.422
0.639AsnTrp: 0.639 ± 0.196
2.272AsnTyr: 2.272 ± 0.394
0.0AsnXaa: 0.0 ± 0.0
Pro
2.91ProAla: 2.91 ± 0.426
0.142ProCys: 0.142 ± 0.11
2.91ProAsp: 2.91 ± 0.431
2.981ProGlu: 2.981 ± 0.625
1.42ProPhe: 1.42 ± 0.343
3.549ProGly: 3.549 ± 0.495
0.852ProHis: 0.852 ± 0.234
2.627ProIle: 2.627 ± 0.457
1.775ProLys: 1.775 ± 0.382
1.846ProLeu: 1.846 ± 0.328
1.491ProMet: 1.491 ± 0.454
2.414ProAsn: 2.414 ± 0.361
1.349ProPro: 1.349 ± 0.237
1.988ProGln: 1.988 ± 0.34
1.207ProArg: 1.207 ± 0.293
2.272ProSer: 2.272 ± 0.376
3.336ProThr: 3.336 ± 0.65
2.556ProVal: 2.556 ± 0.447
0.994ProTrp: 0.994 ± 0.285
1.349ProTyr: 1.349 ± 0.31
0.0ProXaa: 0.0 ± 0.0
Gln
4.969GlnAla: 4.969 ± 0.727
0.355GlnCys: 0.355 ± 0.133
2.343GlnAsp: 2.343 ± 0.469
2.698GlnGlu: 2.698 ± 0.549
1.775GlnPhe: 1.775 ± 0.322
2.627GlnGly: 2.627 ± 0.327
0.994GlnHis: 0.994 ± 0.302
2.698GlnIle: 2.698 ± 0.537
2.556GlnLys: 2.556 ± 0.553
3.762GlnLeu: 3.762 ± 0.534
1.065GlnMet: 1.065 ± 0.275
1.917GlnAsn: 1.917 ± 0.473
1.278GlnPro: 1.278 ± 0.359
2.343GlnGln: 2.343 ± 0.411
2.414GlnArg: 2.414 ± 0.432
2.627GlnSer: 2.627 ± 0.418
2.981GlnThr: 2.981 ± 0.494
2.839GlnVal: 2.839 ± 0.453
0.497GlnTrp: 0.497 ± 0.23
1.136GlnTyr: 1.136 ± 0.217
0.0GlnXaa: 0.0 ± 0.0
Arg
4.117ArgAla: 4.117 ± 0.745
0.639ArgCys: 0.639 ± 0.262
3.123ArgAsp: 3.123 ± 0.439
1.988ArgGlu: 1.988 ± 0.45
1.42ArgPhe: 1.42 ± 0.252
3.265ArgGly: 3.265 ± 0.556
0.852ArgHis: 0.852 ± 0.269
3.691ArgIle: 3.691 ± 0.453
3.123ArgLys: 3.123 ± 0.74
4.756ArgLeu: 4.756 ± 0.587
1.42ArgMet: 1.42 ± 0.376
2.414ArgAsn: 2.414 ± 0.329
1.491ArgPro: 1.491 ± 0.324
1.917ArgGln: 1.917 ± 0.375
3.691ArgArg: 3.691 ± 0.826
3.691ArgSer: 3.691 ± 0.436
3.052ArgThr: 3.052 ± 0.471
1.988ArgVal: 1.988 ± 0.315
0.923ArgTrp: 0.923 ± 0.318
1.349ArgTyr: 1.349 ± 0.377
0.0ArgXaa: 0.0 ± 0.0
Ser
5.679SerAla: 5.679 ± 0.635
0.568SerCys: 0.568 ± 0.187
4.33SerAsp: 4.33 ± 0.496
3.407SerGlu: 3.407 ± 0.483
2.698SerPhe: 2.698 ± 0.391
6.957SerGly: 6.957 ± 1.063
0.852SerHis: 0.852 ± 0.202
3.549SerIle: 3.549 ± 0.509
2.981SerLys: 2.981 ± 0.589
5.182SerLeu: 5.182 ± 0.68
1.349SerMet: 1.349 ± 0.268
3.975SerAsn: 3.975 ± 0.637
2.698SerPro: 2.698 ± 0.378
2.485SerGln: 2.485 ± 0.49
3.478SerArg: 3.478 ± 0.555
4.898SerSer: 4.898 ± 0.78
5.537SerThr: 5.537 ± 0.902
4.188SerVal: 4.188 ± 0.631
1.136SerTrp: 1.136 ± 0.264
2.13SerTyr: 2.13 ± 0.41
0.0SerXaa: 0.0 ± 0.0
Thr
6.673ThrAla: 6.673 ± 0.862
0.497ThrCys: 0.497 ± 0.216
4.543ThrAsp: 4.543 ± 0.602
3.691ThrGlu: 3.691 ± 0.534
2.414ThrPhe: 2.414 ± 0.347
6.318ThrGly: 6.318 ± 1.269
1.278ThrHis: 1.278 ± 0.29
4.614ThrIle: 4.614 ± 0.708
3.265ThrLys: 3.265 ± 0.371
5.679ThrLeu: 5.679 ± 0.676
1.065ThrMet: 1.065 ± 0.25
4.117ThrAsn: 4.117 ± 0.788
3.407ThrPro: 3.407 ± 0.418
2.414ThrGln: 2.414 ± 0.428
2.343ThrArg: 2.343 ± 0.501
5.963ThrSer: 5.963 ± 0.649
6.46ThrThr: 6.46 ± 1.315
4.33ThrVal: 4.33 ± 0.699
0.994ThrTrp: 0.994 ± 0.24
2.627ThrTyr: 2.627 ± 0.464
0.0ThrXaa: 0.0 ± 0.0
Val
5.821ValAla: 5.821 ± 0.628
0.781ValCys: 0.781 ± 0.254
5.253ValAsp: 5.253 ± 0.53
3.762ValGlu: 3.762 ± 0.585
2.485ValPhe: 2.485 ± 0.437
4.259ValGly: 4.259 ± 0.485
1.136ValHis: 1.136 ± 0.299
3.052ValIle: 3.052 ± 0.524
2.839ValLys: 2.839 ± 0.502
3.62ValLeu: 3.62 ± 0.369
1.633ValMet: 1.633 ± 0.378
2.839ValAsn: 2.839 ± 0.453
2.13ValPro: 2.13 ± 0.439
2.414ValGln: 2.414 ± 0.431
2.627ValArg: 2.627 ± 0.36
4.046ValSer: 4.046 ± 0.509
4.827ValThr: 4.827 ± 0.935
4.401ValVal: 4.401 ± 0.61
0.923ValTrp: 0.923 ± 0.236
2.201ValTyr: 2.201 ± 0.424
0.0ValXaa: 0.0 ± 0.0
Trp
0.639TrpAla: 0.639 ± 0.217
0.284TrpCys: 0.284 ± 0.162
0.923TrpAsp: 0.923 ± 0.263
0.781TrpGlu: 0.781 ± 0.247
0.639TrpPhe: 0.639 ± 0.22
0.355TrpGly: 0.355 ± 0.164
0.284TrpHis: 0.284 ± 0.147
0.71TrpIle: 0.71 ± 0.204
0.923TrpLys: 0.923 ± 0.343
1.704TrpLeu: 1.704 ± 0.359
0.71TrpMet: 0.71 ± 0.242
0.568TrpAsn: 0.568 ± 0.191
0.426TrpPro: 0.426 ± 0.141
0.355TrpGln: 0.355 ± 0.188
0.213TrpArg: 0.213 ± 0.137
1.207TrpSer: 1.207 ± 0.38
0.852TrpThr: 0.852 ± 0.228
0.568TrpVal: 0.568 ± 0.174
0.071TrpTrp: 0.071 ± 0.059
0.284TrpTyr: 0.284 ± 0.131
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.627TyrAla: 2.627 ± 0.399
0.355TyrCys: 0.355 ± 0.206
2.698TyrAsp: 2.698 ± 0.588
2.414TyrGlu: 2.414 ± 0.378
0.781TyrPhe: 0.781 ± 0.204
2.839TyrGly: 2.839 ± 0.571
0.426TyrHis: 0.426 ± 0.173
1.349TyrIle: 1.349 ± 0.275
2.414TyrLys: 2.414 ± 0.456
2.414TyrLeu: 2.414 ± 0.364
0.852TyrMet: 0.852 ± 0.274
2.201TyrAsn: 2.201 ± 0.346
1.278TyrPro: 1.278 ± 0.264
1.775TyrGln: 1.775 ± 0.315
1.704TyrArg: 1.704 ± 0.312
2.485TyrSer: 2.485 ± 0.43
1.988TyrThr: 1.988 ± 0.288
2.272TyrVal: 2.272 ± 0.373
0.142TyrTrp: 0.142 ± 0.129
1.562TyrTyr: 1.562 ± 0.407
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 55 proteins (14088 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski