Amino acid dipepetide frequency for Achromobacter piechaudii ATCC 43553

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	17.841AlaAla: 17.841 ± 0.137	1.289AlaCys: 1.289 ± 0.03	7.096AlaAsp: 7.096 ± 0.068	5.882AlaGlu: 5.882 ± 0.075	3.976AlaPhe: 3.976 ± 0.048	11.198AlaGly: 11.198 ± 0.14	2.515AlaHis: 2.515 ± 0.041	5.473AlaIle: 5.473 ± 0.061	3.394AlaLys: 3.394 ± 0.06	14.821AlaLeu: 14.821 ± 0.123	3.671AlaMet: 3.671 ± 0.056	3.1AlaAsn: 3.1 ± 0.077	6.315AlaPro: 6.315 ± 0.077	5.71AlaGln: 5.71 ± 0.06	9.309AlaArg: 9.309 ± 0.081	7.171AlaSer: 7.171 ± 0.096	6.261AlaThr: 6.261 ± 0.078	9.245AlaVal: 9.245 ± 0.125	1.874AlaTrp: 1.874 ± 0.037	2.818AlaTyr: 2.818 ± 0.044	0.0AlaXaa: 0.0 ± 0.0
Cys	1.16CysAla: 1.16 ± 0.027	0.118CysCys: 0.118 ± 0.009	0.479CysAsp: 0.479 ± 0.017	0.418CysGlu: 0.418 ± 0.015	0.276CysPhe: 0.276 ± 0.014	0.916CysGly: 0.916 ± 0.024	0.244CysHis: 0.244 ± 0.012	0.351CysIle: 0.351 ± 0.014	0.206CysLys: 0.206 ± 0.011	0.895CysLeu: 0.895 ± 0.023	0.213CysMet: 0.213 ± 0.012	0.227CysAsn: 0.227 ± 0.012	0.45CysPro: 0.45 ± 0.018	0.272CysGln: 0.272 ± 0.011	0.603CysArg: 0.603 ± 0.018	0.459CysSer: 0.459 ± 0.018	0.44CysThr: 0.44 ± 0.016	0.749CysVal: 0.749 ± 0.023	0.122CysTrp: 0.122 ± 0.01	0.204CysTyr: 0.204 ± 0.012	0.0CysXaa: 0.0 ± 0.0
Asp	7.598AspAla: 7.598 ± 0.076	0.455AspCys: 0.455 ± 0.017	2.833AspAsp: 2.833 ± 0.046	2.997AspGlu: 2.997 ± 0.046	2.009AspPhe: 2.009 ± 0.039	4.985AspGly: 4.985 ± 0.097	1.046AspHis: 1.046 ± 0.029	2.661AspIle: 2.661 ± 0.044	1.669AspLys: 1.669 ± 0.038	5.391AspLeu: 5.391 ± 0.059	1.368AspMet: 1.368 ± 0.027	1.323AspAsn: 1.323 ± 0.036	3.183AspPro: 3.183 ± 0.051	1.733AspGln: 1.733 ± 0.033	3.417AspArg: 3.417 ± 0.049	2.402AspSer: 2.402 ± 0.044	2.956AspThr: 2.956 ± 0.061	4.334AspVal: 4.334 ± 0.053	0.956AspTrp: 0.956 ± 0.024	1.504AspTyr: 1.504 ± 0.033	0.0AspXaa: 0.0 ± 0.0
Glu	5.946GluAla: 5.946 ± 0.081	0.371GluCys: 0.371 ± 0.015	2.295GluAsp: 2.295 ± 0.046	2.187GluGlu: 2.187 ± 0.049	1.681GluPhe: 1.681 ± 0.034	3.468GluGly: 3.468 ± 0.054	1.266GluHis: 1.266 ± 0.027	2.493GluIle: 2.493 ± 0.046	1.609GluLys: 1.609 ± 0.034	5.298GluLeu: 5.298 ± 0.068	1.162GluMet: 1.162 ± 0.029	1.335GluAsn: 1.335 ± 0.029	2.449GluPro: 2.449 ± 0.04	2.414GluGln: 2.414 ± 0.041	4.094GluArg: 4.094 ± 0.062	2.558GluSer: 2.558 ± 0.039	2.412GluThr: 2.412 ± 0.043	3.435GluVal: 3.435 ± 0.051	0.642GluTrp: 0.642 ± 0.016	1.023GluTyr: 1.023 ± 0.025	0.0GluXaa: 0.0 ± 0.0
Phe	3.892PheAla: 3.892 ± 0.05	0.359PheCys: 0.359 ± 0.016	2.394PheAsp: 2.394 ± 0.034	1.799PheGlu: 1.799 ± 0.038	1.293PhePhe: 1.293 ± 0.035	3.312PheGly: 3.312 ± 0.05	0.698PheHis: 0.698 ± 0.021	1.52PheIle: 1.52 ± 0.028	1.093PheLys: 1.093 ± 0.027	3.064PheLeu: 3.064 ± 0.051	0.832PheMet: 0.832 ± 0.023	1.116PheAsn: 1.116 ± 0.026	1.532PhePro: 1.532 ± 0.031	1.113PheGln: 1.113 ± 0.026	1.789PheArg: 1.789 ± 0.036	2.189PheSer: 2.189 ± 0.033	1.872PheThr: 1.872 ± 0.035	2.652PheVal: 2.652 ± 0.042	0.507PheTrp: 0.507 ± 0.019	0.882PheTyr: 0.882 ± 0.024	0.0PheXaa: 0.0 ± 0.0
Gly	9.851GlyAla: 9.851 ± 0.15	0.843GlyCys: 0.843 ± 0.023	4.018GlyAsp: 4.018 ± 0.071	3.949GlyGlu: 3.949 ± 0.056	3.125GlyPhe: 3.125 ± 0.042	7.194GlyGly: 7.194 ± 0.137	1.847GlyHis: 1.847 ± 0.037	4.099GlyIle: 4.099 ± 0.055	3.348GlyLys: 3.348 ± 0.056	8.957GlyLeu: 8.957 ± 0.087	2.646GlyMet: 2.646 ± 0.041	2.387GlyAsn: 2.387 ± 0.067	3.196GlyPro: 3.196 ± 0.041	3.624GlyGln: 3.624 ± 0.054	5.388GlyArg: 5.388 ± 0.061	4.734GlySer: 4.734 ± 0.097	4.482GlyThr: 4.482 ± 0.112	7.081GlyVal: 7.081 ± 0.078	1.408GlyTrp: 1.408 ± 0.033	2.52GlyTyr: 2.52 ± 0.042	0.0GlyXaa: 0.0 ± 0.0
His	2.843HisAla: 2.843 ± 0.043	0.26HisCys: 0.26 ± 0.013	1.258HisAsp: 1.258 ± 0.027	1.043HisGlu: 1.043 ± 0.021	0.776HisPhe: 0.776 ± 0.021	1.992HisGly: 1.992 ± 0.041	0.57HisHis: 0.57 ± 0.021	0.925HisIle: 0.925 ± 0.026	0.498HisLys: 0.498 ± 0.017	2.04HisLeu: 2.04 ± 0.042	0.5HisMet: 0.5 ± 0.018	0.499HisAsn: 0.499 ± 0.018	1.448HisPro: 1.448 ± 0.033	0.716HisGln: 0.716 ± 0.02	1.341HisArg: 1.341 ± 0.032	0.925HisSer: 0.925 ± 0.028	1.045HisThr: 1.045 ± 0.029	1.546HisVal: 1.546 ± 0.03	0.343HisTrp: 0.343 ± 0.017	0.617HisTyr: 0.617 ± 0.019	0.0HisXaa: 0.0 ± 0.0
Ile	6.105IleAla: 6.105 ± 0.061	0.422IleCys: 0.422 ± 0.016	3.061IleAsp: 3.061 ± 0.049	2.753IleGlu: 2.753 ± 0.039	1.336IlePhe: 1.336 ± 0.028	4.298IleGly: 4.298 ± 0.06	0.8IleHis: 0.8 ± 0.022	1.745IleIle: 1.745 ± 0.035	1.472IleLys: 1.472 ± 0.031	3.783IleLeu: 3.783 ± 0.048	0.927IleMet: 0.927 ± 0.024	1.483IleAsn: 1.483 ± 0.038	2.109IlePro: 2.109 ± 0.034	1.429IleGln: 1.429 ± 0.028	2.632IleArg: 2.632 ± 0.035	2.651IleSer: 2.651 ± 0.039	2.511IleThr: 2.511 ± 0.052	3.824IleVal: 3.824 ± 0.047	0.532IleTrp: 0.532 ± 0.018	0.995IleTyr: 0.995 ± 0.023	0.0IleXaa: 0.0 ± 0.0
Lys	3.217LysAla: 3.217 ± 0.055	0.163LysCys: 0.163 ± 0.011	1.459LysAsp: 1.459 ± 0.037	1.373LysGlu: 1.373 ± 0.037	0.863LysPhe: 0.863 ± 0.023	2.168LysGly: 2.168 ± 0.044	0.615LysHis: 0.615 ± 0.018	1.374LysIle: 1.374 ± 0.028	1.232LysLys: 1.232 ± 0.039	3.348LysLeu: 3.348 ± 0.045	0.754LysMet: 0.754 ± 0.022	0.85LysAsn: 0.85 ± 0.025	2.004LysPro: 2.004 ± 0.04	1.348LysGln: 1.348 ± 0.03	2.222LysArg: 2.222 ± 0.04	1.696LysSer: 1.696 ± 0.036	1.864LysThr: 1.864 ± 0.039	2.292LysVal: 2.292 ± 0.039	0.402LysTrp: 0.402 ± 0.016	0.635LysTyr: 0.635 ± 0.02	0.0LysXaa: 0.0 ± 0.0
Leu	15.272LeuAla: 15.272 ± 0.118	1.011LeuCys: 1.011 ± 0.025	6.05LeuAsp: 6.05 ± 0.061	4.721LeuGlu: 4.721 ± 0.057	3.532LeuPhe: 3.532 ± 0.05	8.678LeuGly: 8.678 ± 0.102	2.155LeuHis: 2.155 ± 0.039	4.795LeuIle: 4.795 ± 0.065	3.119LeuLys: 3.119 ± 0.05	10.836LeuLeu: 10.836 ± 0.141	2.55LeuMet: 2.55 ± 0.048	2.943LeuAsn: 2.943 ± 0.043	6.131LeuPro: 6.131 ± 0.081	3.584LeuGln: 3.584 ± 0.05	7.791LeuArg: 7.791 ± 0.076	6.504LeuSer: 6.504 ± 0.062	5.914LeuThr: 5.914 ± 0.065	7.364LeuVal: 7.364 ± 0.081	1.192LeuTrp: 1.192 ± 0.027	2.246LeuTyr: 2.246 ± 0.035	0.0LeuXaa: 0.0 ± 0.0
Met	3.111MetAla: 3.111 ± 0.052	0.177MetCys: 0.177 ± 0.01	1.17MetAsp: 1.17 ± 0.028	0.992MetGlu: 0.992 ± 0.022	0.753MetPhe: 0.753 ± 0.024	1.915MetGly: 1.915 ± 0.036	0.558MetHis: 0.558 ± 0.019	1.085MetIle: 1.085 ± 0.027	0.916MetLys: 0.916 ± 0.025	2.917MetLeu: 2.917 ± 0.049	0.658MetMet: 0.658 ± 0.021	0.855MetAsn: 0.855 ± 0.023	1.608MetPro: 1.608 ± 0.033	1.2MetGln: 1.2 ± 0.023	1.861MetArg: 1.861 ± 0.034	1.733MetSer: 1.733 ± 0.03	1.745MetThr: 1.745 ± 0.035	1.777MetVal: 1.777 ± 0.032	0.218MetTrp: 0.218 ± 0.01	0.432MetTyr: 0.432 ± 0.013	0.0MetXaa: 0.0 ± 0.0
Asn	3.489AsnAla: 3.489 ± 0.064	0.23AsnCys: 0.23 ± 0.012	1.437AsnAsp: 1.437 ± 0.055	1.252AsnGlu: 1.252 ± 0.032	0.895AsnPhe: 0.895 ± 0.023	2.491AsnGly: 2.491 ± 0.075	0.503AsnHis: 0.503 ± 0.018	1.268AsnIle: 1.268 ± 0.035	0.798AsnLys: 0.798 ± 0.023	2.787AsnLeu: 2.787 ± 0.045	0.64AsnMet: 0.64 ± 0.019	0.795AsnAsn: 0.795 ± 0.027	1.86AsnPro: 1.86 ± 0.032	0.907AsnGln: 0.907 ± 0.026	1.704AsnArg: 1.704 ± 0.035	1.267AsnSer: 1.267 ± 0.039	1.517AsnThr: 1.517 ± 0.045	2.164AsnVal: 2.164 ± 0.051	0.428AsnTrp: 0.428 ± 0.017	0.746AsnTyr: 0.746 ± 0.032	0.0AsnXaa: 0.0 ± 0.0
Pro	7.359ProAla: 7.359 ± 0.081	0.34ProCys: 0.34 ± 0.012	3.651ProAsp: 3.651 ± 0.045	3.164ProGlu: 3.164 ± 0.054	1.776ProPhe: 1.776 ± 0.037	4.735ProGly: 4.735 ± 0.053	1.075ProHis: 1.075 ± 0.028	2.019ProIle: 2.019 ± 0.037	1.442ProLys: 1.442 ± 0.03	5.228ProLeu: 5.228 ± 0.066	1.36ProMet: 1.36 ± 0.03	1.325ProAsn: 1.325 ± 0.03	2.571ProPro: 2.571 ± 0.052	2.021ProGln: 2.021 ± 0.039	3.022ProArg: 3.022 ± 0.049	2.85ProSer: 2.85 ± 0.045	2.69ProThr: 2.69 ± 0.043	4.38ProVal: 4.38 ± 0.048	0.785ProTrp: 0.785 ± 0.022	1.377ProTyr: 1.377 ± 0.034	0.0ProXaa: 0.0 ± 0.0
Gln	6.04GlnAla: 6.04 ± 0.068	0.277GlnCys: 0.277 ± 0.014	1.916GlnAsp: 1.916 ± 0.032	1.707GlnGlu: 1.707 ± 0.035	1.191GlnPhe: 1.191 ± 0.027	3.307GlnGly: 3.307 ± 0.052	0.929GlnHis: 0.929 ± 0.024	1.787GlnIle: 1.787 ± 0.038	1.018GlnLys: 1.018 ± 0.023	3.807GlnLeu: 3.807 ± 0.053	0.984GlnMet: 0.984 ± 0.021	0.91GlnAsn: 0.91 ± 0.024	2.182GlnPro: 2.182 ± 0.039	1.82GlnGln: 1.82 ± 0.043	3.112GlnArg: 3.112 ± 0.045	2.089GlnSer: 2.089 ± 0.037	2.017GlnThr: 2.017 ± 0.031	2.919GlnVal: 2.919 ± 0.041	0.672GlnTrp: 0.672 ± 0.021	0.909GlnTyr: 0.909 ± 0.025	0.0GlnXaa: 0.0 ± 0.0
Arg	8.323ArgAla: 8.323 ± 0.075	0.566ArgCys: 0.566 ± 0.021	3.863ArgAsp: 3.863 ± 0.048	3.832ArgGlu: 3.832 ± 0.055	2.38ArgPhe: 2.38 ± 0.039	4.667ArgGly: 4.667 ± 0.054	1.807ArgHis: 1.807 ± 0.035	3.62ArgIle: 3.62 ± 0.05	1.991ArgLys: 1.991 ± 0.038	7.693ArgLeu: 7.693 ± 0.088	1.956ArgMet: 1.956 ± 0.035	1.956ArgAsn: 1.956 ± 0.037	3.254ArgPro: 3.254 ± 0.055	3.079ArgGln: 3.079 ± 0.046	5.164ArgArg: 5.164 ± 0.071	3.304ArgSer: 3.304 ± 0.048	2.987ArgThr: 2.987 ± 0.045	5.239ArgVal: 5.239 ± 0.059	1.069ArgTrp: 1.069 ± 0.027	2.091ArgTyr: 2.091 ± 0.034	0.001ArgXaa: 0.001 ± 0.001
Ser	6.851SerAla: 6.851 ± 0.083	0.41SerCys: 0.41 ± 0.016	2.814SerAsp: 2.814 ± 0.043	2.345SerGlu: 2.345 ± 0.036	2.032SerPhe: 2.032 ± 0.045	5.373SerGly: 5.373 ± 0.095	1.192SerHis: 1.192 ± 0.027	2.461SerIle: 2.461 ± 0.051	1.486SerLys: 1.486 ± 0.029	5.839SerLeu: 5.839 ± 0.058	1.455SerMet: 1.455 ± 0.028	1.532SerAsn: 1.532 ± 0.044	2.921SerPro: 2.921 ± 0.049	2.008SerGln: 2.008 ± 0.033	3.702SerArg: 3.702 ± 0.048	3.134SerSer: 3.134 ± 0.059	3.118SerThr: 3.118 ± 0.061	4.449SerVal: 4.449 ± 0.073	0.788SerTrp: 0.788 ± 0.021	1.341SerTyr: 1.341 ± 0.031	0.0SerXaa: 0.0 ± 0.0
Thr	6.009ThrAla: 6.009 ± 0.09	0.39ThrCys: 0.39 ± 0.015	2.704ThrAsp: 2.704 ± 0.042	2.3ThrGlu: 2.3 ± 0.036	1.799ThrPhe: 1.799 ± 0.038	4.885ThrGly: 4.885 ± 0.102	1.146ThrHis: 1.146 ± 0.024	2.245ThrIle: 2.245 ± 0.048	1.098ThrLys: 1.098 ± 0.025	6.74ThrLeu: 6.74 ± 0.079	1.173ThrMet: 1.173 ± 0.028	1.225ThrAsn: 1.225 ± 0.037	3.828ThrPro: 3.828 ± 0.052	2.042ThrGln: 2.042 ± 0.04	3.554ThrArg: 3.554 ± 0.044	2.77ThrSer: 2.77 ± 0.058	2.828ThrThr: 2.828 ± 0.078	4.465ThrVal: 4.465 ± 0.131	0.708ThrTrp: 0.708 ± 0.02	1.269ThrTyr: 1.269 ± 0.052	0.0ThrXaa: 0.0 ± 0.0
Val	9.735ValAla: 9.735 ± 0.094	0.741ValCys: 0.741 ± 0.024	4.249ValAsp: 4.249 ± 0.068	3.733ValGlu: 3.733 ± 0.054	2.766ValPhe: 2.766 ± 0.04	5.917ValGly: 5.917 ± 0.075	1.448ValHis: 1.448 ± 0.026	3.45ValIle: 3.45 ± 0.051	2.341ValLys: 2.341 ± 0.047	8.462ValLeu: 8.462 ± 0.101	1.934ValMet: 1.934 ± 0.036	2.249ValAsn: 2.249 ± 0.066	4.091ValPro: 4.091 ± 0.057	2.947ValGln: 2.947 ± 0.039	4.972ValArg: 4.972 ± 0.056	4.734ValSer: 4.734 ± 0.091	4.29ValThr: 4.29 ± 0.104	6.415ValVal: 6.415 ± 0.068	0.91ValTrp: 0.91 ± 0.027	1.68ValTyr: 1.68 ± 0.034	0.0ValXaa: 0.0 ± 0.0
Trp	1.284TrpAla: 1.284 ± 0.027	0.136TrpCys: 0.136 ± 0.009	0.597TrpAsp: 0.597 ± 0.02	0.538TrpGlu: 0.538 ± 0.017	0.542TrpPhe: 0.542 ± 0.02	0.944TrpGly: 0.944 ± 0.023	0.34TrpHis: 0.34 ± 0.015	0.662TrpIle: 0.662 ± 0.021	0.454TrpLys: 0.454 ± 0.016	1.992TrpLeu: 1.992 ± 0.048	0.419TrpMet: 0.419 ± 0.015	0.436TrpAsn: 0.436 ± 0.017	0.721TrpPro: 0.721 ± 0.02	0.712TrpGln: 0.712 ± 0.02	1.304TrpArg: 1.304 ± 0.028	0.782TrpSer: 0.782 ± 0.018	0.782TrpThr: 0.782 ± 0.027	0.983TrpVal: 0.983 ± 0.024	0.236TrpTrp: 0.236 ± 0.012	0.312TrpTyr: 0.312 ± 0.013	0.0TrpXaa: 0.0 ± 0.0
Tyr	3.031TyrAla: 3.031 ± 0.045	0.24TyrCys: 0.24 ± 0.011	1.478TyrAsp: 1.478 ± 0.03	1.153TyrGlu: 1.153 ± 0.029	0.907TyrPhe: 0.907 ± 0.022	2.253TyrGly: 2.253 ± 0.039	0.432TyrHis: 0.432 ± 0.017	0.833TyrIle: 0.833 ± 0.023	0.697TyrLys: 0.697 ± 0.019	2.489TyrLeu: 2.489 ± 0.043	0.478TyrMet: 0.478 ± 0.017	0.63TyrAsn: 0.63 ± 0.023	1.317TyrPro: 1.317 ± 0.033	0.916TyrGln: 0.916 ± 0.022	1.86TyrArg: 1.86 ± 0.038	1.301TyrSer: 1.301 ± 0.033	1.447TyrThr: 1.447 ± 0.046	1.752TyrVal: 1.752 ± 0.032	0.385TyrTrp: 0.385 ± 0.015	0.627TyrTyr: 0.627 ± 0.021	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.001XaaLeu: 0.001 ± 0.001	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 5755 proteins (1831974 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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