Amino acid dipepetide frequency for Flavobacterium crassostreae

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	5.226AlaAla: 5.226 ± 0.118	0.583AlaCys: 0.583 ± 0.028	3.213AlaAsp: 3.213 ± 0.064	3.724AlaGlu: 3.724 ± 0.083	3.56AlaPhe: 3.56 ± 0.073	4.044AlaGly: 4.044 ± 0.096	1.222AlaHis: 1.222 ± 0.042	6.44AlaIle: 6.44 ± 0.108	5.415AlaLys: 5.415 ± 0.091	7.446AlaLeu: 7.446 ± 0.096	1.742AlaMet: 1.742 ± 0.047	3.93AlaAsn: 3.93 ± 0.075	2.077AlaPro: 2.077 ± 0.061	3.003AlaGln: 3.003 ± 0.062	2.011AlaArg: 2.011 ± 0.055	4.351AlaSer: 4.351 ± 0.074	4.919AlaThr: 4.919 ± 0.12	4.799AlaVal: 4.799 ± 0.09	0.595AlaTrp: 0.595 ± 0.027	2.646AlaTyr: 2.646 ± 0.06	0.0AlaXaa: 0.0 ± 0.0
Cys	0.474CysAla: 0.474 ± 0.03	0.114CysCys: 0.114 ± 0.013	0.395CysAsp: 0.395 ± 0.024	0.385CysGlu: 0.385 ± 0.024	0.427CysPhe: 0.427 ± 0.024	0.62CysGly: 0.62 ± 0.034	0.18CysHis: 0.18 ± 0.02	0.654CysIle: 0.654 ± 0.031	0.538CysLys: 0.538 ± 0.028	0.7CysLeu: 0.7 ± 0.032	0.142CysMet: 0.142 ± 0.013	0.511CysAsn: 0.511 ± 0.026	0.366CysPro: 0.366 ± 0.025	0.284CysGln: 0.284 ± 0.019	0.188CysArg: 0.188 ± 0.016	0.575CysSer: 0.575 ± 0.03	0.429CysThr: 0.429 ± 0.025	0.479CysVal: 0.479 ± 0.023	0.066CysTrp: 0.066 ± 0.009	0.362CysTyr: 0.362 ± 0.02	0.0CysXaa: 0.0 ± 0.0
Asp	3.894AspAla: 3.894 ± 0.078	0.421AspCys: 0.421 ± 0.023	1.844AspAsp: 1.844 ± 0.051	2.586AspGlu: 2.586 ± 0.062	3.448AspPhe: 3.448 ± 0.07	3.011AspGly: 3.011 ± 0.073	0.843AspHis: 0.843 ± 0.028	3.77AspIle: 3.77 ± 0.062	4.127AspLys: 4.127 ± 0.075	5.312AspLeu: 5.312 ± 0.091	0.916AspMet: 0.916 ± 0.033	2.619AspAsn: 2.619 ± 0.063	1.819AspPro: 1.819 ± 0.046	1.876AspGln: 1.876 ± 0.051	1.685AspArg: 1.685 ± 0.048	2.833AspSer: 2.833 ± 0.065	3.021AspThr: 3.021 ± 0.069	3.051AspVal: 3.051 ± 0.074	0.643AspTrp: 0.643 ± 0.029	2.615AspTyr: 2.615 ± 0.061	0.001AspXaa: 0.001 ± 0.001
Glu	4.344GluAla: 4.344 ± 0.086	0.351GluCys: 0.351 ± 0.021	3.08GluAsp: 3.08 ± 0.067	4.039GluGlu: 4.039 ± 0.098	2.57GluPhe: 2.57 ± 0.049	3.14GluGly: 3.14 ± 0.065	1.021GluHis: 1.021 ± 0.031	5.588GluIle: 5.588 ± 0.1	5.738GluLys: 5.738 ± 0.097	5.857GluLeu: 5.857 ± 0.095	1.561GluMet: 1.561 ± 0.048	4.301GluAsn: 4.301 ± 0.09	1.462GluPro: 1.462 ± 0.042	2.577GluGln: 2.577 ± 0.069	2.161GluArg: 2.161 ± 0.058	2.99GluSer: 2.99 ± 0.068	3.446GluThr: 3.446 ± 0.066	3.888GluVal: 3.888 ± 0.074	0.499GluTrp: 0.499 ± 0.028	2.292GluTyr: 2.292 ± 0.053	0.0GluXaa: 0.0 ± 0.0
Phe	3.354PheAla: 3.354 ± 0.066	0.471PheCys: 0.471 ± 0.025	3.081PheAsp: 3.081 ± 0.064	3.537PheGlu: 3.537 ± 0.077	2.777PhePhe: 2.777 ± 0.077	3.595PheGly: 3.595 ± 0.086	0.804PheHis: 0.804 ± 0.033	3.973PheIle: 3.973 ± 0.08	3.928PheLys: 3.928 ± 0.081	4.831PheLeu: 4.831 ± 0.099	1.086PheMet: 1.086 ± 0.035	2.814PheAsn: 2.814 ± 0.066	1.644PhePro: 1.644 ± 0.045	1.712PheGln: 1.712 ± 0.047	1.614PheArg: 1.614 ± 0.048	3.746PheSer: 3.746 ± 0.083	2.839PheThr: 2.839 ± 0.063	3.239PheVal: 3.239 ± 0.069	0.563PheTrp: 0.563 ± 0.028	2.16PheTyr: 2.16 ± 0.056	0.0PheXaa: 0.0 ± 0.0
Gly	4.143GlyAla: 4.143 ± 0.085	0.649GlyCys: 0.649 ± 0.044	2.711GlyAsp: 2.711 ± 0.065	2.881GlyGlu: 2.881 ± 0.071	3.546GlyPhe: 3.546 ± 0.08	4.012GlyGly: 4.012 ± 0.104	1.088GlyHis: 1.088 ± 0.038	5.45GlyIle: 5.45 ± 0.093	4.724GlyLys: 4.724 ± 0.089	5.593GlyLeu: 5.593 ± 0.071	1.629GlyMet: 1.629 ± 0.048	3.119GlyAsn: 3.119 ± 0.064	1.228GlyPro: 1.228 ± 0.045	1.904GlyGln: 1.904 ± 0.049	1.891GlyArg: 1.891 ± 0.058	3.803GlySer: 3.803 ± 0.083	3.948GlyThr: 3.948 ± 0.104	4.133GlyVal: 4.133 ± 0.076	0.664GlyTrp: 0.664 ± 0.03	2.58GlyTyr: 2.58 ± 0.058	0.0GlyXaa: 0.0 ± 0.0
His	1.169HisAla: 1.169 ± 0.036	0.192HisCys: 0.192 ± 0.017	0.712HisAsp: 0.712 ± 0.031	0.915HisGlu: 0.915 ± 0.032	1.228HisPhe: 1.228 ± 0.044	0.982HisGly: 0.982 ± 0.034	0.452HisHis: 0.452 ± 0.029	1.298HisIle: 1.298 ± 0.035	1.209HisLys: 1.209 ± 0.043	1.957HisLeu: 1.957 ± 0.057	0.279HisMet: 0.279 ± 0.02	0.979HisAsn: 0.979 ± 0.041	0.917HisPro: 0.917 ± 0.038	0.94HisGln: 0.94 ± 0.041	0.631HisArg: 0.631 ± 0.027	1.08HisSer: 1.08 ± 0.036	1.029HisThr: 1.029 ± 0.032	0.877HisVal: 0.877 ± 0.032	0.184HisTrp: 0.184 ± 0.013	0.918HisTyr: 0.918 ± 0.035	0.0HisXaa: 0.0 ± 0.0
Ile	6.82IleAla: 6.82 ± 0.119	0.654IleCys: 0.654 ± 0.028	4.434IleAsp: 4.434 ± 0.08	5.361IleGlu: 5.361 ± 0.094	3.472IlePhe: 3.472 ± 0.08	5.036IleGly: 5.036 ± 0.088	1.542IleHis: 1.542 ± 0.045	5.95IleIle: 5.95 ± 0.098	6.094IleLys: 6.094 ± 0.088	7.614IleLeu: 7.614 ± 0.105	1.462IleMet: 1.462 ± 0.045	4.351IleAsn: 4.351 ± 0.075	3.333IlePro: 3.333 ± 0.059	3.369IleGln: 3.369 ± 0.073	2.473IleArg: 2.473 ± 0.056	5.206IleSer: 5.206 ± 0.088	5.19IleThr: 5.19 ± 0.105	4.952IleVal: 4.952 ± 0.082	0.685IleTrp: 0.685 ± 0.031	2.676IleTyr: 2.676 ± 0.059	0.0IleXaa: 0.0 ± 0.0
Lys	5.472LysAla: 5.472 ± 0.096	0.427LysCys: 0.427 ± 0.028	4.364LysAsp: 4.364 ± 0.084	6.185LysGlu: 6.185 ± 0.1	2.921LysPhe: 2.921 ± 0.06	4.346LysGly: 4.346 ± 0.078	1.267LysHis: 1.267 ± 0.041	7.463LysIle: 7.463 ± 0.101	7.293LysLys: 7.293 ± 0.11	6.461LysLeu: 6.461 ± 0.106	2.274LysMet: 2.274 ± 0.057	5.79LysAsn: 5.79 ± 0.09	2.586LysPro: 2.586 ± 0.052	3.199LysGln: 3.199 ± 0.075	2.657LysArg: 2.657 ± 0.066	4.414LysSer: 4.414 ± 0.072	5.324LysThr: 5.324 ± 0.084	4.523LysVal: 4.523 ± 0.064	0.774LysTrp: 0.774 ± 0.032	3.204LysTyr: 3.204 ± 0.072	0.0LysXaa: 0.0 ± 0.0
Leu	6.642LeuAla: 6.642 ± 0.091	0.756LeuCys: 0.756 ± 0.036	5.296LeuAsp: 5.296 ± 0.082	6.454LeuGlu: 6.454 ± 0.097	5.445LeuPhe: 5.445 ± 0.114	5.925LeuGly: 5.925 ± 0.1	1.814LeuHis: 1.814 ± 0.05	6.842LeuIle: 6.842 ± 0.112	7.895LeuLys: 7.895 ± 0.114	9.639LeuLeu: 9.639 ± 0.154	2.051LeuMet: 2.051 ± 0.058	5.454LeuAsn: 5.454 ± 0.079	3.66LeuPro: 3.66 ± 0.069	4.031LeuGln: 4.031 ± 0.072	3.011LeuArg: 3.011 ± 0.065	6.512LeuSer: 6.512 ± 0.106	5.176LeuThr: 5.176 ± 0.088	5.889LeuVal: 5.889 ± 0.089	0.771LeuTrp: 0.771 ± 0.036	3.367LeuTyr: 3.367 ± 0.075	0.0LeuXaa: 0.0 ± 0.0
Met	1.738MetAla: 1.738 ± 0.05	0.139MetCys: 0.139 ± 0.013	1.245MetAsp: 1.245 ± 0.036	1.298MetGlu: 1.298 ± 0.042	0.806MetPhe: 0.806 ± 0.031	1.383MetGly: 1.383 ± 0.046	0.495MetHis: 0.495 ± 0.025	1.422MetIle: 1.422 ± 0.04	2.106MetLys: 2.106 ± 0.052	2.025MetLeu: 2.025 ± 0.055	0.561MetMet: 0.561 ± 0.028	1.213MetAsn: 1.213 ± 0.032	0.86MetPro: 0.86 ± 0.03	1.078MetGln: 1.078 ± 0.042	0.831MetArg: 0.831 ± 0.035	1.321MetSer: 1.321 ± 0.044	1.18MetThr: 1.18 ± 0.039	1.502MetVal: 1.502 ± 0.046	0.162MetTrp: 0.162 ± 0.012	0.659MetTyr: 0.659 ± 0.031	0.001MetXaa: 0.001 ± 0.001
Asn	4.051AsnAla: 4.051 ± 0.073	0.487AsnCys: 0.487 ± 0.026	2.497AsnAsp: 2.497 ± 0.056	3.157AsnGlu: 3.157 ± 0.081	2.899AsnPhe: 2.899 ± 0.07	3.568AsnGly: 3.568 ± 0.083	1.174AsnHis: 1.174 ± 0.045	4.373AsnIle: 4.373 ± 0.079	4.724AsnLys: 4.724 ± 0.083	5.559AsnLeu: 5.559 ± 0.089	1.166AsnMet: 1.166 ± 0.042	3.847AsnAsn: 3.847 ± 0.102	2.921AsnPro: 2.921 ± 0.065	2.857AsnGln: 2.857 ± 0.062	1.988AsnArg: 1.988 ± 0.057	3.686AsnSer: 3.686 ± 0.075	3.865AsnThr: 3.865 ± 0.081	3.131AsnVal: 3.131 ± 0.071	0.768AsnTrp: 0.768 ± 0.028	2.828AsnTyr: 2.828 ± 0.073	0.001AsnXaa: 0.001 ± 0.001
Pro	2.116ProAla: 2.116 ± 0.062	0.2ProCys: 0.2 ± 0.015	1.823ProAsp: 1.823 ± 0.053	2.966ProGlu: 2.966 ± 0.076	1.871ProPhe: 1.871 ± 0.049	1.644ProGly: 1.644 ± 0.054	0.534ProHis: 0.534 ± 0.026	2.837ProIle: 2.837 ± 0.056	2.957ProLys: 2.957 ± 0.065	3.219ProLeu: 3.219 ± 0.069	0.791ProMet: 0.791 ± 0.035	2.308ProAsn: 2.308 ± 0.051	0.788ProPro: 0.788 ± 0.041	1.234ProGln: 1.234 ± 0.043	0.849ProArg: 0.849 ± 0.032	2.084ProSer: 2.084 ± 0.053	2.218ProThr: 2.218 ± 0.065	2.249ProVal: 2.249 ± 0.058	0.286ProTrp: 0.286 ± 0.021	1.388ProTyr: 1.388 ± 0.049	0.0ProXaa: 0.0 ± 0.0
Gln	2.644GlnAla: 2.644 ± 0.058	0.217GlnCys: 0.217 ± 0.016	1.976GlnAsp: 1.976 ± 0.055	2.802GlnGlu: 2.802 ± 0.075	1.864GlnPhe: 1.864 ± 0.049	1.956GlnGly: 1.956 ± 0.045	0.753GlnHis: 0.753 ± 0.034	3.199GlnIle: 3.199 ± 0.063	4.176GlnLys: 4.176 ± 0.083	4.012GlnLeu: 4.012 ± 0.088	0.93GlnMet: 0.93 ± 0.038	2.931GlnAsn: 2.931 ± 0.075	1.187GlnPro: 1.187 ± 0.041	1.838GlnGln: 1.838 ± 0.056	1.253GlnArg: 1.253 ± 0.036	2.221GlnSer: 2.221 ± 0.05	2.381GlnThr: 2.381 ± 0.052	2.06GlnVal: 2.06 ± 0.055	0.416GlnTrp: 0.416 ± 0.025	1.495GlnTyr: 1.495 ± 0.051	0.0GlnXaa: 0.0 ± 0.0
Arg	2.064ArgAla: 2.064 ± 0.06	0.205ArgCys: 0.205 ± 0.016	1.571ArgAsp: 1.571 ± 0.046	1.911ArgGlu: 1.911 ± 0.049	1.818ArgPhe: 1.818 ± 0.047	1.643ArgGly: 1.643 ± 0.05	0.551ArgHis: 0.551 ± 0.025	2.804ArgIle: 2.804 ± 0.055	2.637ArgLys: 2.637 ± 0.063	3.051ArgLeu: 3.051 ± 0.066	0.912ArgMet: 0.912 ± 0.037	1.901ArgAsn: 1.901 ± 0.052	1.019ArgPro: 1.019 ± 0.035	1.109ArgGln: 1.109 ± 0.04	1.056ArgArg: 1.056 ± 0.042	1.807ArgSer: 1.807 ± 0.049	1.733ArgThr: 1.733 ± 0.046	2.01ArgVal: 2.01 ± 0.051	0.321ArgTrp: 0.321 ± 0.021	1.447ArgTyr: 1.447 ± 0.044	0.0ArgXaa: 0.0 ± 0.0
Ser	3.766SerAla: 3.766 ± 0.059	0.658SerCys: 0.658 ± 0.03	3.027SerAsp: 3.027 ± 0.081	3.568SerGlu: 3.568 ± 0.065	3.699SerPhe: 3.699 ± 0.074	4.387SerGly: 4.387 ± 0.084	1.021SerHis: 1.021 ± 0.037	4.945SerIle: 4.945 ± 0.086	5.092SerLys: 5.092 ± 0.094	5.836SerLeu: 5.836 ± 0.096	1.238SerMet: 1.238 ± 0.04	3.577SerAsn: 3.577 ± 0.072	1.983SerPro: 1.983 ± 0.053	2.322SerGln: 2.322 ± 0.055	2.01SerArg: 2.01 ± 0.051	4.027SerSer: 4.027 ± 0.077	3.244SerThr: 3.244 ± 0.071	3.91SerVal: 3.91 ± 0.083	0.67SerTrp: 0.67 ± 0.03	2.68SerTyr: 2.68 ± 0.073	0.0SerXaa: 0.0 ± 0.0
Thr	4.683ThrAla: 4.683 ± 0.126	0.333ThrCys: 0.333 ± 0.024	3.324ThrAsp: 3.324 ± 0.071	3.405ThrGlu: 3.405 ± 0.071	2.805ThrPhe: 2.805 ± 0.056	3.743ThrGly: 3.743 ± 0.103	1.085ThrHis: 1.085 ± 0.044	5.525ThrIle: 5.525 ± 0.116	4.477ThrLys: 4.477 ± 0.073	5.73ThrLeu: 5.73 ± 0.087	0.997ThrMet: 0.997 ± 0.036	3.741ThrAsn: 3.741 ± 0.083	2.652ThrPro: 2.652 ± 0.064	2.515ThrGln: 2.515 ± 0.064	1.497ThrArg: 1.497 ± 0.039	3.509ThrSer: 3.509 ± 0.075	4.383ThrThr: 4.383 ± 0.104	3.939ThrVal: 3.939 ± 0.108	0.427ThrTrp: 0.427 ± 0.024	2.294ThrTyr: 2.294 ± 0.07	0.0ThrXaa: 0.0 ± 0.0
Val	5.147ValAla: 5.147 ± 0.094	0.558ValCys: 0.558 ± 0.025	3.137ValAsp: 3.137 ± 0.066	3.141ValGlu: 3.141 ± 0.069	3.61ValPhe: 3.61 ± 0.073	3.733ValGly: 3.733 ± 0.071	1.044ValHis: 1.044 ± 0.039	4.613ValIle: 4.613 ± 0.076	4.06ValLys: 4.06 ± 0.073	6.728ValLeu: 6.728 ± 0.107	1.316ValMet: 1.316 ± 0.044	3.072ValAsn: 3.072 ± 0.073	2.17ValPro: 2.17 ± 0.05	2.091ValGln: 2.091 ± 0.05	2.0ValArg: 2.0 ± 0.052	4.214ValSer: 4.214 ± 0.092	3.779ValThr: 3.779 ± 0.122	4.675ValVal: 4.675 ± 0.093	0.512ValTrp: 0.512 ± 0.027	2.349ValTyr: 2.349 ± 0.061	0.0ValXaa: 0.0 ± 0.0
Trp	0.583TrpAla: 0.583 ± 0.029	0.1TrpCys: 0.1 ± 0.012	0.5TrpAsp: 0.5 ± 0.026	0.569TrpGlu: 0.569 ± 0.024	0.546TrpPhe: 0.546 ± 0.028	0.538TrpGly: 0.538 ± 0.026	0.209TrpHis: 0.209 ± 0.017	0.823TrpIle: 0.823 ± 0.031	0.728TrpLys: 0.728 ± 0.03	0.922TrpLeu: 0.922 ± 0.039	0.289TrpMet: 0.289 ± 0.023	0.669TrpAsn: 0.669 ± 0.029	0.165TrpPro: 0.165 ± 0.018	0.382TrpGln: 0.382 ± 0.025	0.335TrpArg: 0.335 ± 0.019	0.659TrpSer: 0.659 ± 0.029	0.484TrpThr: 0.484 ± 0.025	0.532TrpVal: 0.532 ± 0.025	0.105TrpTrp: 0.105 ± 0.012	0.407TrpTyr: 0.407 ± 0.022	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.617TyrAla: 2.617 ± 0.056	0.373TyrCys: 0.373 ± 0.02	2.105TyrAsp: 2.105 ± 0.055	2.022TyrGlu: 2.022 ± 0.052	2.457TyrPhe: 2.457 ± 0.063	2.391TyrGly: 2.391 ± 0.06	0.848TyrHis: 0.848 ± 0.035	2.704TyrIle: 2.704 ± 0.066	3.025TyrLys: 3.025 ± 0.066	4.135TyrLeu: 4.135 ± 0.086	0.68TyrMet: 0.68 ± 0.026	2.422TyrAsn: 2.422 ± 0.074	1.524TyrPro: 1.524 ± 0.042	1.988TyrGln: 1.988 ± 0.056	1.427TyrArg: 1.427 ± 0.054	2.624TyrSer: 2.624 ± 0.061	2.482TyrThr: 2.482 ± 0.076	2.11TyrVal: 2.11 ± 0.047	0.435TyrTrp: 0.435 ± 0.02	1.859TyrTyr: 1.859 ± 0.053	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.001XaaIle: 0.001 ± 0.001	0.001XaaLys: 0.001 ± 0.001	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.001XaaTyr: 0.001 ± 0.001	0.001XaaXaa: 0.001 ± 0.001

Statistics based on 2424 proteins (798124 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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