Amino acid dipepetide frequency for Catalinimonas alkaloidigena

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	8.212AlaAla: 8.212 ± 0.085	0.828AlaCys: 0.828 ± 0.025	5.003AlaAsp: 5.003 ± 0.049	5.24AlaGlu: 5.24 ± 0.061	3.946AlaPhe: 3.946 ± 0.045	6.506AlaGly: 6.506 ± 0.069	2.035AlaHis: 2.035 ± 0.041	4.035AlaIle: 4.035 ± 0.043	2.947AlaLys: 2.947 ± 0.053	10.08AlaLeu: 10.08 ± 0.1	1.904AlaMet: 1.904 ± 0.036	2.888AlaAsn: 2.888 ± 0.051	3.966AlaPro: 3.966 ± 0.058	4.655AlaGln: 4.655 ± 0.053	4.756AlaArg: 4.756 ± 0.053	5.116AlaSer: 5.116 ± 0.059	5.489AlaThr: 5.489 ± 0.069	5.724AlaVal: 5.724 ± 0.057	1.434AlaTrp: 1.434 ± 0.029	3.431AlaTyr: 3.431 ± 0.044	0.0AlaXaa: 0.0 ± 0.0
Cys	0.632CysAla: 0.632 ± 0.023	0.109CysCys: 0.109 ± 0.009	0.391CysAsp: 0.391 ± 0.014	0.391CysGlu: 0.391 ± 0.015	0.337CysPhe: 0.337 ± 0.012	0.605CysGly: 0.605 ± 0.02	0.215CysHis: 0.215 ± 0.012	0.388CysIle: 0.388 ± 0.014	0.212CysLys: 0.212 ± 0.01	0.832CysLeu: 0.832 ± 0.021	0.139CysMet: 0.139 ± 0.01	0.246CysAsn: 0.246 ± 0.01	0.351CysPro: 0.351 ± 0.016	0.343CysGln: 0.343 ± 0.012	0.45CysArg: 0.45 ± 0.016	0.44CysSer: 0.44 ± 0.019	0.463CysThr: 0.463 ± 0.021	0.449CysVal: 0.449 ± 0.014	0.108CysTrp: 0.108 ± 0.007	0.268CysTyr: 0.268 ± 0.011	0.0CysXaa: 0.0 ± 0.0
Asp	4.841AspAla: 4.841 ± 0.053	0.337AspCys: 0.337 ± 0.013	2.868AspAsp: 2.868 ± 0.043	3.504AspGlu: 3.504 ± 0.048	2.745AspPhe: 2.745 ± 0.037	4.21AspGly: 4.21 ± 0.093	1.208AspHis: 1.208 ± 0.029	2.586AspIle: 2.586 ± 0.045	1.923AspLys: 1.923 ± 0.033	5.709AspLeu: 5.709 ± 0.06	0.972AspMet: 0.972 ± 0.022	1.816AspAsn: 1.816 ± 0.035	2.948AspPro: 2.948 ± 0.042	2.53AspGln: 2.53 ± 0.04	3.309AspArg: 3.309 ± 0.048	2.793AspSer: 2.793 ± 0.052	2.823AspThr: 2.823 ± 0.053	3.917AspVal: 3.917 ± 0.046	0.89AspTrp: 0.89 ± 0.022	2.376AspTyr: 2.376 ± 0.041	0.0AspXaa: 0.0 ± 0.0
Glu	6.552GluAla: 6.552 ± 0.069	0.295GluCys: 0.295 ± 0.013	2.751GluAsp: 2.751 ± 0.045	4.403GluGlu: 4.403 ± 0.07	2.155GluPhe: 2.155 ± 0.034	4.52GluGly: 4.52 ± 0.052	1.319GluHis: 1.319 ± 0.029	3.254GluIle: 3.254 ± 0.051	3.306GluLys: 3.306 ± 0.051	5.88GluLeu: 5.88 ± 0.063	1.482GluMet: 1.482 ± 0.027	2.435GluAsn: 2.435 ± 0.037	2.274GluPro: 2.274 ± 0.031	2.836GluGln: 2.836 ± 0.045	3.949GluArg: 3.949 ± 0.059	2.762GluSer: 2.762 ± 0.04	3.404GluThr: 3.404 ± 0.044	4.637GluVal: 4.637 ± 0.056	0.793GluTrp: 0.793 ± 0.02	1.816GluTyr: 1.816 ± 0.031	0.0GluXaa: 0.0 ± 0.0
Phe	3.636PheAla: 3.636 ± 0.043	0.421PheCys: 0.421 ± 0.017	2.653PheAsp: 2.653 ± 0.042	2.613PheGlu: 2.613 ± 0.038	2.159PhePhe: 2.159 ± 0.036	3.271PheGly: 3.271 ± 0.04	0.949PheHis: 0.949 ± 0.019	1.945PheIle: 1.945 ± 0.037	1.396PheLys: 1.396 ± 0.03	4.463PheLeu: 4.463 ± 0.055	0.907PheMet: 0.907 ± 0.023	1.746PheAsn: 1.746 ± 0.037	1.895PhePro: 1.895 ± 0.032	1.879PheGln: 1.879 ± 0.031	2.841PheArg: 2.841 ± 0.038	3.084PheSer: 3.084 ± 0.04	2.836PheThr: 2.836 ± 0.043	3.097PheVal: 3.097 ± 0.041	0.686PheTrp: 0.686 ± 0.021	1.854PheTyr: 1.854 ± 0.026	0.0PheXaa: 0.0 ± 0.0
Gly	5.624GlyAla: 5.624 ± 0.066	0.703GlyCys: 0.703 ± 0.047	3.782GlyAsp: 3.782 ± 0.061	3.979GlyGlu: 3.979 ± 0.045	3.28GlyPhe: 3.28 ± 0.044	5.597GlyGly: 5.597 ± 0.093	1.487GlyHis: 1.487 ± 0.031	4.136GlyIle: 4.136 ± 0.056	3.489GlyLys: 3.489 ± 0.054	7.208GlyLeu: 7.208 ± 0.078	1.802GlyMet: 1.802 ± 0.031	3.019GlyAsn: 3.019 ± 0.061	2.303GlyPro: 2.303 ± 0.04	3.244GlyGln: 3.244 ± 0.04	3.797GlyArg: 3.797 ± 0.048	4.223GlySer: 4.223 ± 0.073	5.081GlyThr: 5.081 ± 0.094	5.128GlyVal: 5.128 ± 0.055	1.331GlyTrp: 1.331 ± 0.028	3.078GlyTyr: 3.078 ± 0.047	0.0GlyXaa: 0.0 ± 0.0
His	1.83HisAla: 1.83 ± 0.035	0.212HisCys: 0.212 ± 0.01	1.218HisAsp: 1.218 ± 0.026	1.329HisGlu: 1.329 ± 0.03	1.256HisPhe: 1.256 ± 0.027	1.381HisGly: 1.381 ± 0.026	0.789HisHis: 0.789 ± 0.023	1.046HisIle: 1.046 ± 0.026	0.724HisLys: 0.724 ± 0.019	2.713HisLeu: 2.713 ± 0.044	0.433HisMet: 0.433 ± 0.015	0.773HisAsn: 0.773 ± 0.017	1.579HisPro: 1.579 ± 0.026	1.164HisGln: 1.164 ± 0.024	1.458HisArg: 1.458 ± 0.029	1.009HisSer: 1.009 ± 0.021	1.351HisThr: 1.351 ± 0.03	1.484HisVal: 1.484 ± 0.031	0.402HisTrp: 0.402 ± 0.014	1.126HisTyr: 1.126 ± 0.026	0.0HisXaa: 0.0 ± 0.0
Ile	4.44IleAla: 4.44 ± 0.048	0.385IleCys: 0.385 ± 0.016	3.132IleAsp: 3.132 ± 0.041	2.978IleGlu: 2.978 ± 0.046	2.011IlePhe: 2.011 ± 0.035	3.93IleGly: 3.93 ± 0.048	1.102IleHis: 1.102 ± 0.028	2.311IleIle: 2.311 ± 0.044	1.952IleLys: 1.952 ± 0.039	4.282IleLeu: 4.282 ± 0.06	0.802IleMet: 0.802 ± 0.02	2.158IleAsn: 2.158 ± 0.038	2.412IlePro: 2.412 ± 0.04	1.976IleGln: 1.976 ± 0.035	3.293IleArg: 3.293 ± 0.048	3.036IleSer: 3.036 ± 0.041	3.093IleThr: 3.093 ± 0.045	3.186IleVal: 3.186 ± 0.042	0.564IleTrp: 0.564 ± 0.018	1.746IleTyr: 1.746 ± 0.03	0.0IleXaa: 0.0 ± 0.0
Lys	3.733LysAla: 3.733 ± 0.058	0.184LysCys: 0.184 ± 0.009	1.997LysAsp: 1.997 ± 0.037	2.861LysGlu: 2.861 ± 0.056	1.332LysPhe: 1.332 ± 0.029	2.808LysGly: 2.808 ± 0.042	0.837LysHis: 0.837 ± 0.022	2.257LysIle: 2.257 ± 0.04	2.472LysLys: 2.472 ± 0.049	3.73LysLeu: 3.73 ± 0.047	1.021LysMet: 1.021 ± 0.023	1.791LysAsn: 1.791 ± 0.035	1.85LysPro: 1.85 ± 0.03	1.747LysGln: 1.747 ± 0.03	2.367LysArg: 2.367 ± 0.045	2.041LysSer: 2.041 ± 0.036	2.321LysThr: 2.321 ± 0.038	2.836LysVal: 2.836 ± 0.041	0.524LysTrp: 0.524 ± 0.015	1.454LysTyr: 1.454 ± 0.032	0.0LysXaa: 0.0 ± 0.0
Leu	9.297LeuAla: 9.297 ± 0.088	0.843LeuCys: 0.843 ± 0.02	5.5LeuAsp: 5.5 ± 0.059	6.064LeuGlu: 6.064 ± 0.067	4.648LeuPhe: 4.648 ± 0.061	6.806LeuGly: 6.806 ± 0.06	2.54LeuHis: 2.54 ± 0.043	5.105LeuIle: 5.105 ± 0.061	4.417LeuLys: 4.417 ± 0.054	11.394LeuLeu: 11.394 ± 0.128	2.316LeuMet: 2.316 ± 0.035	4.149LeuAsn: 4.149 ± 0.065	5.518LeuPro: 5.518 ± 0.065	4.954LeuGln: 4.954 ± 0.062	6.492LeuArg: 6.492 ± 0.063	6.599LeuSer: 6.599 ± 0.065	6.705LeuThr: 6.705 ± 0.069	7.034LeuVal: 7.034 ± 0.076	1.421LeuTrp: 1.421 ± 0.032	3.802LeuTyr: 3.802 ± 0.047	0.0LeuXaa: 0.0 ± 0.0
Met	1.947MetAla: 1.947 ± 0.028	0.115MetCys: 0.115 ± 0.007	0.997MetAsp: 0.997 ± 0.02	1.223MetGlu: 1.223 ± 0.025	0.643MetPhe: 0.643 ± 0.021	1.422MetGly: 1.422 ± 0.028	0.529MetHis: 0.529 ± 0.017	1.067MetIle: 1.067 ± 0.025	1.269MetLys: 1.269 ± 0.026	2.237MetLeu: 2.237 ± 0.036	0.563MetMet: 0.563 ± 0.016	0.946MetAsn: 0.946 ± 0.022	1.124MetPro: 1.124 ± 0.02	1.105MetGln: 1.105 ± 0.026	1.308MetArg: 1.308 ± 0.025	1.166MetSer: 1.166 ± 0.024	1.133MetThr: 1.133 ± 0.023	1.386MetVal: 1.386 ± 0.028	0.193MetTrp: 0.193 ± 0.011	0.581MetTyr: 0.581 ± 0.016	0.0MetXaa: 0.0 ± 0.0
Asn	3.321AsnAla: 3.321 ± 0.053	0.259AsnCys: 0.259 ± 0.013	2.046AsnAsp: 2.046 ± 0.041	2.151AsnGlu: 2.151 ± 0.032	1.74AsnPhe: 1.74 ± 0.031	3.276AsnGly: 3.276 ± 0.082	0.832AsnHis: 0.832 ± 0.02	1.797AsnIle: 1.797 ± 0.038	1.284AsnLys: 1.284 ± 0.031	4.086AsnLeu: 4.086 ± 0.059	0.699AsnMet: 0.699 ± 0.017	1.578AsnAsn: 1.578 ± 0.044	2.399AsnPro: 2.399 ± 0.04	1.872AsnGln: 1.872 ± 0.035	2.434AsnArg: 2.434 ± 0.036	1.916AsnSer: 1.916 ± 0.038	2.219AsnThr: 2.219 ± 0.044	2.682AsnVal: 2.682 ± 0.045	0.587AsnTrp: 0.587 ± 0.017	1.713AsnTyr: 1.713 ± 0.031	0.0AsnXaa: 0.0 ± 0.0
Pro	4.577ProAla: 4.577 ± 0.055	0.232ProCys: 0.232 ± 0.011	3.556ProAsp: 3.556 ± 0.049	3.607ProGlu: 3.607 ± 0.041	2.095ProPhe: 2.095 ± 0.035	3.296ProGly: 3.296 ± 0.049	1.172ProHis: 1.172 ± 0.025	2.049ProIle: 2.049 ± 0.03	1.547ProLys: 1.547 ± 0.029	4.811ProLeu: 4.811 ± 0.052	0.958ProMet: 0.958 ± 0.025	1.925ProAsn: 1.925 ± 0.03	2.022ProPro: 2.022 ± 0.037	2.105ProGln: 2.105 ± 0.037	2.111ProArg: 2.111 ± 0.029	2.679ProSer: 2.679 ± 0.041	3.024ProThr: 3.024 ± 0.038	3.606ProVal: 3.606 ± 0.042	0.635ProTrp: 0.635 ± 0.019	1.809ProTyr: 1.809 ± 0.031	0.0ProXaa: 0.0 ± 0.0
Gln	4.457GlnAla: 4.457 ± 0.055	0.244GlnCys: 0.244 ± 0.012	2.044GlnAsp: 2.044 ± 0.034	3.203GlnGlu: 3.203 ± 0.048	1.872GlnPhe: 1.872 ± 0.033	3.031GlnGly: 3.031 ± 0.045	1.333GlnHis: 1.333 ± 0.026	2.096GlnIle: 2.096 ± 0.034	2.079GlnLys: 2.079 ± 0.039	5.181GlnLeu: 5.181 ± 0.06	0.929GlnMet: 0.929 ± 0.023	1.64GlnAsn: 1.64 ± 0.035	2.534GlnPro: 2.534 ± 0.038	2.859GlnGln: 2.859 ± 0.049	3.055GlnArg: 3.055 ± 0.048	2.242GlnSer: 2.242 ± 0.037	2.755GlnThr: 2.755 ± 0.039	3.467GlnVal: 3.467 ± 0.044	0.724GlnTrp: 0.724 ± 0.021	1.617GlnTyr: 1.617 ± 0.027	0.0GlnXaa: 0.0 ± 0.0
Arg	4.522ArgAla: 4.522 ± 0.056	0.341ArgCys: 0.341 ± 0.012	2.927ArgAsp: 2.927 ± 0.041	3.625ArgGlu: 3.625 ± 0.051	2.946ArgPhe: 2.946 ± 0.038	3.364ArgGly: 3.364 ± 0.049	1.516ArgHis: 1.516 ± 0.035	3.242ArgIle: 3.242 ± 0.044	2.697ArgLys: 2.697 ± 0.047	6.417ArgLeu: 6.417 ± 0.063	1.434ArgMet: 1.434 ± 0.025	2.473ArgAsn: 2.473 ± 0.038	2.639ArgPro: 2.639 ± 0.034	3.182ArgGln: 3.182 ± 0.051	3.606ArgArg: 3.606 ± 0.049	2.931ArgSer: 2.931 ± 0.044	3.377ArgThr: 3.377 ± 0.048	3.924ArgVal: 3.924 ± 0.043	1.099ArgTrp: 1.099 ± 0.023	2.697ArgTyr: 2.697 ± 0.034	0.0ArgXaa: 0.0 ± 0.0
Ser	4.726SerAla: 4.726 ± 0.05	0.478SerCys: 0.478 ± 0.015	2.994SerAsp: 2.994 ± 0.039	3.008SerGlu: 3.008 ± 0.036	2.906SerPhe: 2.906 ± 0.039	4.561SerGly: 4.561 ± 0.069	1.17SerHis: 1.17 ± 0.025	2.856SerIle: 2.856 ± 0.045	1.886SerLys: 1.886 ± 0.033	6.402SerLeu: 6.402 ± 0.053	1.135SerMet: 1.135 ± 0.023	2.111SerAsn: 2.111 ± 0.048	2.779SerPro: 2.779 ± 0.042	2.106SerGln: 2.106 ± 0.034	2.897SerArg: 2.897 ± 0.037	3.381SerSer: 3.381 ± 0.052	3.368SerThr: 3.368 ± 0.053	4.098SerVal: 4.098 ± 0.047	0.784SerTrp: 0.784 ± 0.021	2.24SerTyr: 2.24 ± 0.039	0.0SerXaa: 0.0 ± 0.0
Thr	5.104ThrAla: 5.104 ± 0.057	0.414ThrCys: 0.414 ± 0.018	3.518ThrAsp: 3.518 ± 0.056	3.287ThrGlu: 3.287 ± 0.042	2.813ThrPhe: 2.813 ± 0.052	4.76ThrGly: 4.76 ± 0.072	1.457ThrHis: 1.457 ± 0.029	2.989ThrIle: 2.989 ± 0.046	1.919ThrLys: 1.919 ± 0.034	7.29ThrLeu: 7.29 ± 0.066	0.948ThrMet: 0.948 ± 0.023	2.209ThrAsn: 2.209 ± 0.047	3.603ThrPro: 3.603 ± 0.047	2.645ThrGln: 2.645 ± 0.04	2.906ThrArg: 2.906 ± 0.038	3.51ThrSer: 3.51 ± 0.048	3.844ThrThr: 3.844 ± 0.063	4.236ThrVal: 4.236 ± 0.068	0.961ThrTrp: 0.961 ± 0.024	2.556ThrTyr: 2.556 ± 0.046	0.0ThrXaa: 0.0 ± 0.0
Val	6.397ValAla: 6.397 ± 0.059	0.553ValCys: 0.553 ± 0.019	3.757ValAsp: 3.757 ± 0.042	4.153ValGlu: 4.153 ± 0.05	2.848ValPhe: 2.848 ± 0.039	4.987ValGly: 4.987 ± 0.056	1.454ValHis: 1.454 ± 0.025	3.433ValIle: 3.433 ± 0.038	2.717ValLys: 2.717 ± 0.04	7.076ValLeu: 7.076 ± 0.069	1.53ValMet: 1.53 ± 0.029	2.714ValAsn: 2.714 ± 0.05	3.306ValPro: 3.306 ± 0.041	3.047ValGln: 3.047 ± 0.044	4.246ValArg: 4.246 ± 0.057	4.189ValSer: 4.189 ± 0.058	4.508ValThr: 4.508 ± 0.071	5.592ValVal: 5.592 ± 0.057	0.975ValTrp: 0.975 ± 0.025	2.55ValTyr: 2.55 ± 0.034	0.0ValXaa: 0.0 ± 0.0
Trp	1.098TrpAla: 1.098 ± 0.023	0.121TrpCys: 0.121 ± 0.007	0.791TrpAsp: 0.791 ± 0.018	0.898TrpGlu: 0.898 ± 0.017	0.611TrpPhe: 0.611 ± 0.017	1.104TrpGly: 1.104 ± 0.024	0.366TrpHis: 0.366 ± 0.012	0.735TrpIle: 0.735 ± 0.022	0.628TrpLys: 0.628 ± 0.02	1.715TrpLeu: 1.715 ± 0.036	0.396TrpMet: 0.396 ± 0.014	0.653TrpAsn: 0.653 ± 0.017	0.516TrpPro: 0.516 ± 0.016	0.983TrpGln: 0.983 ± 0.024	0.86TrpArg: 0.86 ± 0.023	0.828TrpSer: 0.828 ± 0.023	0.813TrpThr: 0.813 ± 0.024	1.022TrpVal: 1.022 ± 0.026	0.292TrpTrp: 0.292 ± 0.013	0.528TrpTyr: 0.528 ± 0.02	0.0TrpXaa: 0.0 ± 0.0
Tyr	3.248TyrAla: 3.248 ± 0.046	0.297TyrCys: 0.297 ± 0.014	2.377TyrAsp: 2.377 ± 0.038	2.307TyrGlu: 2.307 ± 0.037	1.991TyrPhe: 1.991 ± 0.035	2.856TyrGly: 2.856 ± 0.042	0.971TyrHis: 0.971 ± 0.026	1.46TyrIle: 1.46 ± 0.029	1.297TyrLys: 1.297 ± 0.032	4.097TyrLeu: 4.097 ± 0.043	0.586TyrMet: 0.586 ± 0.017	1.619TyrAsn: 1.619 ± 0.033	1.799TyrPro: 1.799 ± 0.031	2.132TyrGln: 2.132 ± 0.034	2.824TyrArg: 2.824 ± 0.039	1.941TyrSer: 1.941 ± 0.032	2.357TyrThr: 2.357 ± 0.04	2.528TyrVal: 2.528 ± 0.035	0.554TyrTrp: 0.554 ± 0.017	1.787TyrTyr: 1.787 ± 0.035	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 5672 proteins (2097683 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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