Amino acid dipepetide frequency for Talaromyces rugulosus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	8.546AlaAla: 8.546 ± 0.054	1.066AlaCys: 1.066 ± 0.016	4.153AlaAsp: 4.153 ± 0.026	4.743AlaGlu: 4.743 ± 0.042	3.18AlaPhe: 3.18 ± 0.021	5.51AlaGly: 5.51 ± 0.036	1.709AlaHis: 1.709 ± 0.016	4.515AlaIle: 4.515 ± 0.029	3.77AlaLys: 3.77 ± 0.03	7.598AlaLeu: 7.598 ± 0.046	1.862AlaMet: 1.862 ± 0.019	3.046AlaAsn: 3.046 ± 0.023	4.169AlaPro: 4.169 ± 0.037	3.21AlaGln: 3.21 ± 0.031	4.462AlaArg: 4.462 ± 0.032	7.021AlaSer: 7.021 ± 0.035	5.204AlaThr: 5.204 ± 0.031	5.346AlaVal: 5.346 ± 0.037	1.164AlaTrp: 1.164 ± 0.016	2.217AlaTyr: 2.217 ± 0.02	0.0AlaXaa: 0.0 ± 0.0
Cys	0.914CysAla: 0.914 ± 0.014	0.219CysCys: 0.219 ± 0.006	0.674CysAsp: 0.674 ± 0.011	0.591CysGlu: 0.591 ± 0.01	0.56CysPhe: 0.56 ± 0.01	0.883CysGly: 0.883 ± 0.012	0.343CysHis: 0.343 ± 0.008	0.734CysIle: 0.734 ± 0.011	0.483CysLys: 0.483 ± 0.01	1.31CysLeu: 1.31 ± 0.016	0.25CysMet: 0.25 ± 0.007	0.44CysAsn: 0.44 ± 0.009	0.617CysPro: 0.617 ± 0.011	0.466CysGln: 0.466 ± 0.01	0.731CysArg: 0.731 ± 0.013	0.919CysSer: 0.919 ± 0.014	0.68CysThr: 0.68 ± 0.011	0.806CysVal: 0.806 ± 0.012	0.211CysTrp: 0.211 ± 0.005	0.375CysTyr: 0.375 ± 0.01	0.0CysXaa: 0.0 ± 0.0
Asp	4.444AspAla: 4.444 ± 0.03	0.627AspCys: 0.627 ± 0.011	4.186AspAsp: 4.186 ± 0.039	4.308AspGlu: 4.308 ± 0.034	2.334AspPhe: 2.334 ± 0.02	3.933AspGly: 3.933 ± 0.026	1.305AspHis: 1.305 ± 0.016	3.463AspIle: 3.463 ± 0.026	2.394AspLys: 2.394 ± 0.022	5.164AspLeu: 5.164 ± 0.032	1.237AspMet: 1.237 ± 0.014	2.135AspAsn: 2.135 ± 0.02	3.167AspPro: 3.167 ± 0.027	1.977AspGln: 1.977 ± 0.018	2.975AspArg: 2.975 ± 0.025	4.459AspSer: 4.459 ± 0.026	3.106AspThr: 3.106 ± 0.026	3.629AspVal: 3.629 ± 0.024	0.903AspTrp: 0.903 ± 0.01	1.709AspTyr: 1.709 ± 0.02	0.0AspXaa: 0.0 ± 0.0
Glu	4.951GluAla: 4.951 ± 0.043	0.593GluCys: 0.593 ± 0.013	4.037GluAsp: 4.037 ± 0.034	5.185GluGlu: 5.185 ± 0.057	2.025GluPhe: 2.025 ± 0.019	3.372GluGly: 3.372 ± 0.028	1.349GluHis: 1.349 ± 0.017	3.344GluIle: 3.344 ± 0.025	3.743GluLys: 3.743 ± 0.032	5.078GluLeu: 5.078 ± 0.034	1.377GluMet: 1.377 ± 0.014	2.685GluAsn: 2.685 ± 0.018	2.612GluPro: 2.612 ± 0.042	2.452GluGln: 2.452 ± 0.022	3.587GluArg: 3.587 ± 0.029	4.358GluSer: 4.358 ± 0.032	3.658GluThr: 3.658 ± 0.025	3.29GluVal: 3.29 ± 0.026	0.898GluTrp: 0.898 ± 0.013	1.754GluTyr: 1.754 ± 0.02	0.0GluXaa: 0.0 ± 0.0
Phe	3.084PheAla: 3.084 ± 0.028	0.578PheCys: 0.578 ± 0.011	2.404PheAsp: 2.404 ± 0.02	2.202PheGlu: 2.202 ± 0.021	1.769PhePhe: 1.769 ± 0.019	2.878PheGly: 2.878 ± 0.028	0.976PheHis: 0.976 ± 0.014	1.98PheIle: 1.98 ± 0.02	1.494PheLys: 1.494 ± 0.017	3.722PheLeu: 3.722 ± 0.029	0.794PheMet: 0.794 ± 0.013	1.53PheAsn: 1.53 ± 0.016	2.035PhePro: 2.035 ± 0.02	1.517PheGln: 1.517 ± 0.015	1.941PheArg: 1.941 ± 0.021	3.306PheSer: 3.306 ± 0.023	2.24PheThr: 2.24 ± 0.019	2.541PheVal: 2.541 ± 0.023	0.699PheTrp: 0.699 ± 0.012	1.216PheTyr: 1.216 ± 0.014	0.0PheXaa: 0.0 ± 0.0
Gly	5.001GlyAla: 5.001 ± 0.032	0.863GlyCys: 0.863 ± 0.013	3.589GlyAsp: 3.589 ± 0.028	3.383GlyGlu: 3.383 ± 0.026	2.912GlyPhe: 2.912 ± 0.025	5.414GlyGly: 5.414 ± 0.052	1.7GlyHis: 1.7 ± 0.02	3.789GlyIle: 3.789 ± 0.028	3.283GlyLys: 3.283 ± 0.031	6.155GlyLeu: 6.155 ± 0.031	1.471GlyMet: 1.471 ± 0.016	2.655GlyAsn: 2.655 ± 0.024	3.137GlyPro: 3.137 ± 0.026	2.56GlyGln: 2.56 ± 0.022	3.778GlyArg: 3.778 ± 0.029	5.593GlySer: 5.593 ± 0.034	3.835GlyThr: 3.835 ± 0.03	4.311GlyVal: 4.311 ± 0.029	1.151GlyTrp: 1.151 ± 0.013	2.217GlyTyr: 2.217 ± 0.021	0.0GlyXaa: 0.0 ± 0.0
His	1.832HisAla: 1.832 ± 0.017	0.312HisCys: 0.312 ± 0.008	1.337HisAsp: 1.337 ± 0.016	1.355HisGlu: 1.355 ± 0.016	0.942HisPhe: 0.942 ± 0.012	1.704HisGly: 1.704 ± 0.018	0.869HisHis: 0.869 ± 0.017	1.312HisIle: 1.312 ± 0.014	0.914HisLys: 0.914 ± 0.014	2.264HisLeu: 2.264 ± 0.023	0.487HisMet: 0.487 ± 0.011	0.895HisAsn: 0.895 ± 0.013	1.65HisPro: 1.65 ± 0.02	1.019HisGln: 1.019 ± 0.014	1.516HisArg: 1.516 ± 0.016	1.881HisSer: 1.881 ± 0.018	1.31HisThr: 1.31 ± 0.015	1.471HisVal: 1.471 ± 0.017	0.36HisTrp: 0.36 ± 0.007	0.72HisTyr: 0.72 ± 0.01	0.0HisXaa: 0.0 ± 0.0
Ile	4.33IleAla: 4.33 ± 0.031	0.798IleCys: 0.798 ± 0.012	3.134IleAsp: 3.134 ± 0.021	3.03IleGlu: 3.03 ± 0.028	2.243IlePhe: 2.243 ± 0.022	3.481IleGly: 3.481 ± 0.029	1.343IleHis: 1.343 ± 0.013	2.82IleIle: 2.82 ± 0.028	2.276IleLys: 2.276 ± 0.02	4.949IleLeu: 4.949 ± 0.032	1.044IleMet: 1.044 ± 0.012	2.003IleAsn: 2.003 ± 0.018	3.204IlePro: 3.204 ± 0.022	2.136IleGln: 2.136 ± 0.02	2.857IleArg: 2.857 ± 0.02	4.369IleSer: 4.369 ± 0.029	3.038IleThr: 3.038 ± 0.023	3.401IleVal: 3.401 ± 0.029	0.788IleTrp: 0.788 ± 0.012	1.585IleTyr: 1.585 ± 0.017	0.0IleXaa: 0.0 ± 0.0
Lys	3.935LysAla: 3.935 ± 0.033	0.496LysCys: 0.496 ± 0.011	2.752LysAsp: 2.752 ± 0.025	3.273LysGlu: 3.273 ± 0.031	1.502LysPhe: 1.502 ± 0.016	2.805LysGly: 2.805 ± 0.025	1.097LysHis: 1.097 ± 0.014	2.391LysIle: 2.391 ± 0.021	3.131LysLys: 3.131 ± 0.037	4.107LysLeu: 4.107 ± 0.027	0.977LysMet: 0.977 ± 0.014	1.933LysAsn: 1.933 ± 0.018	2.561LysPro: 2.561 ± 0.022	1.86LysGln: 1.86 ± 0.019	3.159LysArg: 3.159 ± 0.03	3.498LysSer: 3.498 ± 0.028	2.937LysThr: 2.937 ± 0.028	2.719LysVal: 2.719 ± 0.022	0.679LysTrp: 0.679 ± 0.01	1.446LysTyr: 1.446 ± 0.017	0.0LysXaa: 0.0 ± 0.0
Leu	7.836LeuAla: 7.836 ± 0.045	1.228LeuCys: 1.228 ± 0.015	5.4LeuAsp: 5.4 ± 0.037	5.523LeuGlu: 5.523 ± 0.035	3.59LeuPhe: 3.59 ± 0.03	6.045LeuGly: 6.045 ± 0.031	2.304LeuHis: 2.304 ± 0.021	4.214LeuIle: 4.214 ± 0.032	4.167LeuLys: 4.167 ± 0.033	8.679LeuLeu: 8.679 ± 0.048	1.757LeuMet: 1.757 ± 0.02	3.343LeuAsn: 3.343 ± 0.027	5.343LeuPro: 5.343 ± 0.033	4.074LeuGln: 4.074 ± 0.029	5.487LeuArg: 5.487 ± 0.032	7.692LeuSer: 7.692 ± 0.042	4.847LeuThr: 4.847 ± 0.031	5.613LeuVal: 5.613 ± 0.036	1.252LeuTrp: 1.252 ± 0.015	2.531LeuTyr: 2.531 ± 0.022	0.0LeuXaa: 0.0 ± 0.0
Met	2.144MetAla: 2.144 ± 0.02	0.238MetCys: 0.238 ± 0.006	1.174MetAsp: 1.174 ± 0.015	1.234MetGlu: 1.234 ± 0.015	0.765MetPhe: 0.765 ± 0.01	1.393MetGly: 1.393 ± 0.014	0.491MetHis: 0.491 ± 0.01	1.044MetIle: 1.044 ± 0.012	0.934MetLys: 0.934 ± 0.013	1.825MetLeu: 1.825 ± 0.017	0.538MetMet: 0.538 ± 0.01	0.809MetAsn: 0.809 ± 0.012	1.135MetPro: 1.135 ± 0.013	0.854MetGln: 0.854 ± 0.012	1.139MetArg: 1.139 ± 0.014	1.811MetSer: 1.811 ± 0.017	1.298MetThr: 1.298 ± 0.014	1.281MetVal: 1.281 ± 0.015	0.26MetTrp: 0.26 ± 0.006	0.509MetTyr: 0.509 ± 0.01	0.0MetXaa: 0.0 ± 0.0
Asn	3.143AsnAla: 3.143 ± 0.026	0.468AsnCys: 0.468 ± 0.009	2.215AsnAsp: 2.215 ± 0.018	2.211AsnGlu: 2.211 ± 0.02	1.488AsnPhe: 1.488 ± 0.016	2.995AsnGly: 2.995 ± 0.027	0.923AsnHis: 0.923 ± 0.014	2.339AsnIle: 2.339 ± 0.022	1.687AsnLys: 1.687 ± 0.02	3.416AsnLeu: 3.416 ± 0.025	0.887AsnMet: 0.887 ± 0.012	2.007AsnAsn: 2.007 ± 0.025	2.469AsnPro: 2.469 ± 0.022	1.47AsnGln: 1.47 ± 0.017	2.012AsnArg: 2.012 ± 0.019	3.13AsnSer: 3.13 ± 0.025	2.474AsnThr: 2.474 ± 0.021	2.469AsnVal: 2.469 ± 0.024	0.618AsnTrp: 0.618 ± 0.009	1.166AsnTyr: 1.166 ± 0.013	0.0AsnXaa: 0.0 ± 0.0
Pro	4.673ProAla: 4.673 ± 0.035	0.52ProCys: 0.52 ± 0.01	3.145ProAsp: 3.145 ± 0.024	3.686ProGlu: 3.686 ± 0.037	2.084ProPhe: 2.084 ± 0.02	3.732ProGly: 3.732 ± 0.035	1.261ProHis: 1.261 ± 0.015	2.613ProIle: 2.613 ± 0.019	2.459ProLys: 2.459 ± 0.025	4.694ProLeu: 4.694 ± 0.032	0.975ProMet: 0.975 ± 0.014	2.174ProAsn: 2.174 ± 0.017	4.529ProPro: 4.529 ± 0.06	2.348ProGln: 2.348 ± 0.022	3.104ProArg: 3.104 ± 0.028	5.721ProSer: 5.721 ± 0.041	3.645ProThr: 3.645 ± 0.029	3.509ProVal: 3.509 ± 0.027	0.758ProTrp: 0.758 ± 0.012	1.519ProTyr: 1.519 ± 0.017	0.0ProXaa: 0.0 ± 0.0
Gln	3.28GlnAla: 3.28 ± 0.028	0.472GlnCys: 0.472 ± 0.009	2.105GlnAsp: 2.105 ± 0.019	2.405GlnGlu: 2.405 ± 0.023	1.397GlnPhe: 1.397 ± 0.015	2.486GlnGly: 2.486 ± 0.023	1.078GlnHis: 1.078 ± 0.014	2.005GlnIle: 2.005 ± 0.019	2.095GlnLys: 2.095 ± 0.018	3.595GlnLeu: 3.595 ± 0.027	0.842GlnMet: 0.842 ± 0.01	1.745GlnAsn: 1.745 ± 0.019	2.47GlnPro: 2.47 ± 0.021	2.647GlnGln: 2.647 ± 0.05	2.565GlnArg: 2.565 ± 0.02	3.259GlnSer: 3.259 ± 0.028	2.447GlnThr: 2.447 ± 0.022	2.249GlnVal: 2.249 ± 0.02	0.617GlnTrp: 0.617 ± 0.009	1.259GlnTyr: 1.259 ± 0.015	0.0GlnXaa: 0.0 ± 0.0
Arg	4.22ArgAla: 4.22 ± 0.028	0.672ArgCys: 0.672 ± 0.012	3.231ArgAsp: 3.231 ± 0.028	3.57ArgGlu: 3.57 ± 0.03	2.151ArgPhe: 2.151 ± 0.019	3.443ArgGly: 3.443 ± 0.033	1.522ArgHis: 1.522 ± 0.016	2.951ArgIle: 2.951 ± 0.022	3.215ArgLys: 3.215 ± 0.027	5.448ArgLeu: 5.448 ± 0.035	1.178ArgMet: 1.178 ± 0.014	2.264ArgAsn: 2.264 ± 0.019	3.169ArgPro: 3.169 ± 0.027	2.579ArgGln: 2.579 ± 0.02	4.676ArgArg: 4.676 ± 0.039	4.43ArgSer: 4.43 ± 0.029	3.054ArgThr: 3.054 ± 0.02	3.318ArgVal: 3.318 ± 0.024	0.919ArgTrp: 0.919 ± 0.014	1.659ArgTyr: 1.659 ± 0.018	0.0ArgXaa: 0.0 ± 0.0
Ser	6.38SerAla: 6.38 ± 0.036	0.886SerCys: 0.886 ± 0.013	4.406SerAsp: 4.406 ± 0.029	4.254SerGlu: 4.254 ± 0.031	3.228SerPhe: 3.228 ± 0.021	5.467SerGly: 5.467 ± 0.033	2.001SerHis: 2.001 ± 0.02	4.381SerIle: 4.381 ± 0.026	3.762SerLys: 3.762 ± 0.029	7.727SerLeu: 7.727 ± 0.04	1.714SerMet: 1.714 ± 0.019	3.321SerAsn: 3.321 ± 0.026	5.251SerPro: 5.251 ± 0.044	3.464SerGln: 3.464 ± 0.025	4.869SerArg: 4.869 ± 0.031	9.176SerSer: 9.176 ± 0.066	5.754SerThr: 5.754 ± 0.039	4.8SerVal: 4.8 ± 0.032	1.209SerTrp: 1.209 ± 0.015	2.227SerTyr: 2.227 ± 0.02	0.0SerXaa: 0.0 ± 0.0
Thr	5.252ThrAla: 5.252 ± 0.035	0.728ThrCys: 0.728 ± 0.013	2.98ThrAsp: 2.98 ± 0.022	3.236ThrGlu: 3.236 ± 0.026	2.306ThrPhe: 2.306 ± 0.021	4.239ThrGly: 4.239 ± 0.035	1.279ThrHis: 1.279 ± 0.014	3.288ThrIle: 3.288 ± 0.026	2.643ThrLys: 2.643 ± 0.023	5.282ThrLeu: 5.282 ± 0.035	1.199ThrMet: 1.199 ± 0.014	2.293ThrAsn: 2.293 ± 0.019	3.999ThrPro: 3.999 ± 0.031	2.164ThrGln: 2.164 ± 0.018	3.011ThrArg: 3.011 ± 0.025	5.415ThrSer: 5.415 ± 0.04	4.605ThrThr: 4.605 ± 0.046	3.908ThrVal: 3.908 ± 0.031	0.896ThrTrp: 0.896 ± 0.014	1.679ThrTyr: 1.679 ± 0.019	0.0ThrXaa: 0.0 ± 0.0
Val	5.158ValAla: 5.158 ± 0.033	0.821ValCys: 0.821 ± 0.011	3.877ValAsp: 3.877 ± 0.029	3.712ValGlu: 3.712 ± 0.029	2.587ValPhe: 2.587 ± 0.018	3.96ValGly: 3.96 ± 0.03	1.424ValHis: 1.424 ± 0.015	3.242ValIle: 3.242 ± 0.025	2.813ValLys: 2.813 ± 0.021	5.693ValLeu: 5.693 ± 0.032	1.275ValMet: 1.275 ± 0.013	2.393ValAsn: 2.393 ± 0.018	3.475ValPro: 3.475 ± 0.027	2.427ValGln: 2.427 ± 0.018	3.249ValArg: 3.249 ± 0.023	4.885ValSer: 4.885 ± 0.032	3.601ValThr: 3.601 ± 0.027	4.376ValVal: 4.376 ± 0.033	0.845ValTrp: 0.845 ± 0.013	1.805ValTyr: 1.805 ± 0.017	0.0ValXaa: 0.0 ± 0.0
Trp	1.173TrpAla: 1.173 ± 0.017	0.202TrpCys: 0.202 ± 0.006	0.913TrpAsp: 0.913 ± 0.017	0.867TrpGlu: 0.867 ± 0.011	0.555TrpPhe: 0.555 ± 0.01	0.921TrpGly: 0.921 ± 0.014	0.362TrpHis: 0.362 ± 0.008	0.825TrpIle: 0.825 ± 0.012	0.866TrpLys: 0.866 ± 0.012	1.404TrpLeu: 1.404 ± 0.015	0.366TrpMet: 0.366 ± 0.008	0.7TrpAsn: 0.7 ± 0.01	0.629TrpPro: 0.629 ± 0.01	0.603TrpGln: 0.603 ± 0.011	0.913TrpArg: 0.913 ± 0.012	1.103TrpSer: 1.103 ± 0.014	0.946TrpThr: 0.946 ± 0.012	0.913TrpVal: 0.913 ± 0.01	0.29TrpTrp: 0.29 ± 0.007	0.44TrpTyr: 0.44 ± 0.008	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.193TyrAla: 2.193 ± 0.019	0.419TyrCys: 0.419 ± 0.008	1.74TyrAsp: 1.74 ± 0.017	1.579TyrGlu: 1.579 ± 0.016	1.289TyrPhe: 1.289 ± 0.016	2.138TyrGly: 2.138 ± 0.02	0.814TyrHis: 0.814 ± 0.012	1.58TyrIle: 1.58 ± 0.015	1.13TyrLys: 1.13 ± 0.014	2.816TyrLeu: 2.816 ± 0.02	0.646TyrMet: 0.646 ± 0.01	1.215TyrAsn: 1.215 ± 0.014	1.527TyrPro: 1.527 ± 0.016	1.19TyrGln: 1.19 ± 0.014	1.638TyrArg: 1.638 ± 0.018	2.251TyrSer: 2.251 ± 0.02	1.725TyrThr: 1.725 ± 0.019	1.669TyrVal: 1.669 ± 0.016	0.474TyrTrp: 0.474 ± 0.009	1.013TyrTyr: 1.013 ± 0.014	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 11830 proteins (6275300 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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